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  • 1.
    Abd Alwaheb, Sofia
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Implementering DevSecOps metodik vid systemutveckling för hälso och sjukvård2023Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    In healthcare, IT security is crucial for protecting both personal information and patient safety. Currently, the implementation of security measures and testing is done after software development, which can reduce efficiency, and pose a potential risk to patient privacy. This study examined the implementation of the DevSecOps methodology in healthcare, focusing on the development phase. By interviewing employees and using security tools such as SAST, code review, penetration testing, and DAST, benefits and challenges were identified. The challenges included a lack of security knowledge and difficulty integrating tools for free. Despite this, the results demonstrated the potential to enhance security, streamline operations, and save money by utilizing free tools and implementing security during the development phase. Training and hiring security-competent personnel were also emphasized as important for maintaining high security standards.

    Download full text (pdf)
    fulltext
  • 2.
    Abdalla, Osman
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Design and implementation of a signaling system for a novel light-baseed bioprinter: Design och implementering av ett signalsystem för en ny ljusbaserad bioprinter2023Independent thesis Basic level (university diploma), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    A 3D bioprinter employing light-based technology has been designed and constructed in an EU-funded research initiative known as BRIGHTER (Bioprinting by Light-Sheet Lithography). This initiative is a collaborative effort between institutions and companies and aims to develop a technique for efficient and accurate production of engineered tissue.

    Presently, the bioprinter’s function is limited to 2D printing, with the lack of 3D printing capabilities. 

    The problem addressed is the integration of two separate electronic systems within the bioprinter to control the laser beam’s trajectory for 3D printing. The goal of the project is to create functional software and simulation tools to control the hardware modules in a precise and synchronized manner, thereby enabling 3D printing.

    The outcome manifests as a software prototype, which successfully facilitates intercommunication between the two electronic subsystems within the bioprinter, thereby enabling further progress on the bioprinter with 3D printing available. Nevertheless, the prototype requires thorough testing to determine its optimal operational efficiency in terms of timing the movements for the various hardware modules.

    Download full text (pdf)
    Bioprinter
  • 3.
    Abdi Dahir, Najiib
    et al.
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Dahir Ali, Ikran
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Privacy preserving data access mechanism for health data2023Independent thesis Basic level (university diploma), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Due to the rise of digitalization and the growing amount of data, ensuring the integrity and security of patient data has become increasingly vital within the healthcare industry, which has traditionally managed substantial quantities of sensitive patient and personal information. This bachelor's thesis focused on designing and implementing a secure data sharing infrastructure to protect the integrity and confidentiality of patient data. Synthetic data was used to enable access for researchers and students in regulated environments without compromising patient privacy. The project successfully achieved its goals by evaluating different privacy-preserving mechanisms and developing a machine learning-based application to demonstrate the functionality of the secure data sharing infrastructure. Despite some challenges, the chosen algorithms showed promising results in terms of privacy preservation and statistical similarity. Ultimately, the use of synthetic data can promote fair decision-making processes and contribute to secure data sharing practices in the healthcare industry.

    Download full text (pdf)
    Examensarbete
  • 4.
    Abdirahman, Khalid
    et al.
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Förnberg, Sebastian
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Styrsystem för solcellsladdade batterier2018Independent thesis Basic level (university diploma), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The use of solar cells is continuously increasing in Sweden and the powergenerated by the solar cells is usually stored in lead acid batteries. These batterieshave a bad impact on the environment as much energy and environmentallyhazardous materials like lead and sulfuric acid are required to manufacture thesebatteries. Östersjökompaniet AB and many of its customers realize the importanceof sustainable thinking and were interested in knowing if it was possible tomaximize the lifetime of these batteries. During the course of the work, differentmethods of battery charging and discharging were analyzed that could affect thebatteries lifetime and how to take care of them to optimize them. A chargecontroller was used to optimize the charge of the battery. To calculate theremaining state of charge in the battery, the Extended voltmeter method was used.A prototype that was able to charge the batteries optimally, warn when the batterycapacity became too low, and a user-friendly application for battery monitoring wasdesigned. The calculated lifetime of a battery is not an exact science. According tostudies the lifetime of a battery can be doubled if it is c

    Download full text (pdf)
    Styrsystem för solcellsladdade batterier
  • 5.
    Abdulnoor, John
    et al.
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Gawriyeh, Ramy
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    A study of methods to synchronize different sensors between two smartphones2021Independent thesis Basic level (university diploma), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Obtaining data simultaneously from different sensors located on different mobile devices can be useful for applications such as sports and medicine. In order for the data from the different sensors to be combined for analysis, the mobile devices need to be time synchronized first. This paper presents an application that can be used to calculate the difference between the internal clocks of two android devices using a combination of the Cristian and Marzullo algorithms. Different methods to connect the devices over Wi-Fi as well as the internet are tested to determine the optimal method for clock synchronization. The paper also validates the synchronization by testing different sensors on two identical android smartphones. The results show that clock synchronization between two mobile devices can be achieved with a round-trip time of 2 milliseconds or less using Wi-Fi Direct. Validation of the synchronization shows that a delay of 7 milliseconds or less can be achieved between two sensors of the same type on two identical android smartphones. It also shows that the least achievable delay between sensors of different types is 16 milliseconds. The conclusion is that once two android smartphones’ clocks are synchronized, only data from sensors of the same type can be combined, with the exception of the camera sensor. Further testing with more robust equipment is needed in order to eliminate human error which could possibly yield more desirable results.

    Download full text (pdf)
    fulltext
  • 6.
    Abourraja, Mohamed Nezar
    et al.
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Kringos, Nicole
    KTH, School of Architecture and the Built Environment (ABE), Civil and Architectural Engineering, Structural Engineering and Bridges.
    Meijer, Sebastiaan
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Exploiting simulation model potential in investigating handling capacity of Ro-Ro terminals: The case study of Norvik seaport2022In: Simulation Modelling Practice and Theory, ISSN 1569-190X, Vol. 117, p. 102513-102513, article id 102513Article in journal (Refereed)
    Abstract [en]

    In this paper, the spotlight is directed towards studying the handling capacity of pure Ro-Ro terminals, especially the new terminal of Norvik port. To this end, a simulation model based on a distributed architecture is built to assess the handling capacity under different flow scenarios with a particular focus on the trailer flow and export-lorry flow the terminal can handle in terms of resource availability, trailer-dwell times and management rules. This helped to determine the number of resources required to evacuate smoothly the incoming flows and to identify where potential bottlenecks happen the most inside the terminal. The established model is verified then validated by experts to conduct properly the experiment study where the model is fed with empirical data provided by terminal authorities. This experiment showed that the terminal can handle flows of which trailers do not exceed 17% and the export fraction of lorries is at most 42%.

  • 7.
    Abourraja, Mohamed Nezar
    et al.
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Kringos, Nicole
    KTH, School of Architecture and the Built Environment (ABE), Civil and Architectural Engineering, Structural Engineering and Bridges.
    Meijer, Sebastiaan
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Proposal of a module-driven architecture for building simulation models devoted to container terminals: dilemmas in applying generic, flexible, and modular principles2023In: Simulation (San Diego, Calif.), ISSN 0037-5497, E-ISSN 1741-3133, Vol. 99, no 7, p. 703-727Article in journal (Refereed)
    Abstract [en]

    Container terminals are complex systems where containerized cargo undergoes a set of processing and handling operations to be delivered to their outgoing modes. A pool of decision support methods and simulation models has been developed to assist planners and managers in making decisions about daily operations. Nevertheless, most are designed for a particular terminal and not generic types. Indeed, a generic model serves as a conceptual factory to create specific models which greatly reduces the time and efforts of development; however, building such a model is no mean feat. To this aim, the paper on hand discusses the complexity of applying genericity, flexibility, and modularity in system modeling and proposes a generic architecture to build modular and flexible simulation models for container terminals. This architecture is split into a set of smaller, manageable, well-connected, and generic modules that facilitate the creation of highly parametrized specific models. An illustrative example of the architecture usage is presented in a case study, the new container terminal of Stockholm, and the resulting models were validated by subject matter experts. Finally, to prove its efficiency, a numerical study fed with real data is conducted to investigate the handling capacity of the studied system under different handling and flow scenarios. The obtained results show that the terminal handling capacity can be increased by around 50% if three to four more straddle carriers are added to the existing fleet.

  • 8.
    Abourraja, Mohamed Nezar
    et al.
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Marzano, Luca
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Raghothama, Jayanth
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Boodaghian Asl, Arsineh
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Darwich, Adam S.
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Meijer, Sebastiaan
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Lethvall, Sven
    Uppsala University Hospital,Uppsala,Sweden.
    Falk, Nina
    Uppsala University Hospital,Uppsala,Sweden.
    A Data-Driven Discrete Event Simulation Model to Improve Emergency Department Logistics2022In: Proceedings of the 2022 Winter Simulation Conference, Institute of Electrical and Electronics Engineers (IEEE) , 2022Conference paper (Refereed)
    Abstract [en]

    Demands for health care are becoming overwhelming for healthcare systems around the world regarding theavailability of resources, particularly, in emergency departments (EDs) that are continuously open and mustserve immediately any patient who comes in. Efficient management of EDs and their resources is requiredmore than ever. This could be achieved either by optimizing resource utilization or by the improvement ofhospital layout. This paper investigates, through data-driven simulation alternative designs of workflowsand layouts to operate the ED of the Uppsala University Hospital in Sweden. Results are analyzed tounderstand the requirements across the hospital for reduced waiting times in the ED. The main observationrevealed that introducing a new ward dedicated to patients having complex diagnoses with a capacity ofless than 20 beds leads to lower waiting times. Furthermore, the use of data-mining was of great help inreducing the efforts of building the simulation model.

  • 9.
    Abourraja, Mohamed Nezar
    et al.
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Meijer, Sebastiaan
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Boukachour, Jaouad
    Normandie University, UNIHAVRE, 76600 Le Havre, France.
    A model-driven design approach for Ro-Ro and container terminals: from requirements analysis down to simulation model implementation2021In: 20th International Conference on Modeling and Applied Simulation, MAS 2021, Cal-Tek Srl , 2021, p. 9-20Conference paper (Refereed)
    Abstract [en]

    Modeling, one of the main pillars of good scientific research, is a long-standing multidisciplinary activity to understand and analyze complex systems. In this paper, the focus is directed toward conceptual modeling of multi-terminal seaports specialized in handling and treatment of intermodal transport units (ITU). These systems are complex with highly dynamic and stochastic behaviors and actors, therefore, studying them as a coherent whole or just analyzing one part by taking into account the high degree of integration among the different aspects and actors linked by a flow of activities, information, and interactions is a bet lost in advance without a well-defined design process. Several design approaches and methodologies have been proposed over the years, but nonetheless, there is still no agreement on how to conduct modeling of complex systems because they are of different kinds. In this line, this paper proposes a top-down approach for container and Ro-Ro terminals largely inspired by the Unified Process Methodology and refined through several research projects that we have been involved in. It gives some recommendations and guidelines as well as a helpful way to successfully build modular and consistent simulation models. To prove its efficiency, it was applied to a case study and the resulting models were validated by the subject matter's experts.

  • 10.
    Abourraja, Mohamed Nezar
    et al.
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics. Ecole Cent Casablanca, Casablanca, Morocco..
    Rouky, Naoufal
    Euro-Mediterranean University, Fez, Morocco.
    Kornevs, Maksims
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Meijer, Sebastiaan
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Kringos, Nicole
    KTH, School of Architecture and the Built Environment (ABE), Civil and Architectural Engineering, Structural Engineering and Bridges. Euro Mediterranean Univ, Fes, Morocco..
    A simulation-based decision support framework devoted to Ro-Ro terminals: Design, implementation and evaluation2023In: Computers & industrial engineering, ISSN 0360-8352, E-ISSN 1879-0550, Vol. 180, p. 109248-, article id 109248Article in journal (Refereed)
    Abstract [en]

    As a type of intermodal terminal, pure Ro-Ro terminals are one of the most important logistic hubs in the supply chain for rolling freight stored in containerized and wheeled steel boxes. These large-scale systems are highly complex, with nonlinear and hard-to-predict behavior evolving in a stochastic environment. Consequently, making decisions about any problem thereof is no mean feat, particularly for terminal planners. To assist them in decision-making, a pool of relevant models and tools have been developed over the years in the literature. Nevertheless, models that are oriented toward specific objectives dominate, and generic ones are rare. This paper tries to fill this gap and proposes a generic framework to be used as a factory to create specific decision support models based on simulation for pure Ro-Ro terminals. This framework is formulated following two artifacts: (1) the known classification of key performance indicators combined with the typical functional and physical organization of pure Ro-Ro terminals; (2) the three main arteries of harbor systems, namely flows, decisions and operations. Then a scalable way of making decisions based on a flexible form of the cost function weighted according to a set of coefficients is integrated. These designed coefficients allow decision-makers a wide flexibly in choosing how the best solutions are determined. An application of this framework is illustrated through a real case study, where the weights are estimated using an expert-profiling based approach then pushed into the OptQuest optimizer to be calibrated before analyzing the results. These results are aggregated, then expressed as scores on a scale of 0 to 1. This is to help terminal planners to easily identify the worst and best planning scenarios as well as the relationships and compatibilities between the involved handling rules to suggest different alternatives for managing operations.

  • 11.
    Abraham, Johannes
    et al.
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Romano, Robin
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Automatisk kvalitetssäkring av information för järnvägsanläggningar: Automatic quality assurance of information for railway infrastructure2019Independent thesis Basic level (university diploma), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    With increased expectations for the expansion of the future railway, this entails an increased load on the current railway network. The result of the expansion can be an increasing number of cancellations and delays. By taking advantage of technological innovations such as digitalization and automation, the existing system and work  processes can be developed for more efficient management.   The Swedish Transport Administration sets requirements for Building Information Modeling (BIM) in procurements. The planning of signal installations within the railway takes place in Sweco using the CAD program Promis.e. From the program, lists containing the information of the objects (BIS-lists) can be retrieved. The  Swedish Transport Administration requires that the attributes must consist of a  certain format or have specific values. In this thesis project, methods for automatic quality assurance of infrastructure information and the implementation of the method for rail projects were examined. The investigated methods include the  calculation program Excel, the query programming language SQL and the process of ETL.  After analyzing the methods, the ETL process was chosen. The result was that a  program was created to automatically select the type of BIS list that would be  reviewed and to verify that the examined attributes contained allowed values. In  order to investigate whether the cost of the programs would benefit the company in addition to the quality assurance, an economic analysis was carried out. According to the calculations, the choice of method could also be justified from an economic  perspective.

    Download full text (pdf)
    Examensarbete
  • 12.
    Adolfsson, Tobias
    et al.
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Dellenby, Axel
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Pre-study of optical LED units for shunting signals2021Independent thesis Basic level (university diploma), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Alstom wanted to investigate the possibility of adapting its light emitting diode (LED) technology for shunting signals in train traffic. The LED technology uses 50V, but Alstom wants to adapt it for 12V. The LED technology is energy efficient but needs to be adapted for existing signal interlocking by drawing a higher current. This meant that the possibility of reactive power compensation was investigated to obtain lower thermal dissipation in dwarf signal. The essay presents a couple of possible solutions. One of the solutions is to raise the voltage by using a booster converter to use the existing 50V LED unit. Capacitors were reviewed to be used in reactive power compensation to increase current supply. One of the solutions then became a capacitor bank. Simulations indicated that a booster converter and a capacitor bank can be used to adapt the circuit. However, some modifications must be made.

    Download full text (pdf)
    fulltext
  • 13.
    Ahluwalia, A.
    et al.
    Italy.
    De Maria, C.
    Italy.
    Lantada, A. D.
    Spain.
    Pietro, L. D.
    Italy.
    Ravizza, A.
    Italy.
    Mridha, Mannan
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Madete, J.
    Kenya.
    Makobore, P. N.
    Uganda.
    Aabloo, A.
    Estonia.
    Kitsing, R.
    Estonia.
    Leivobits, A.
    Estonia.
    Towards open source medical devices current situation, inspiring advances and challenges2018In: BIODEVICES 2018 - 11th International Conference on Biomedical Electronics and Devices, Proceedings; Part of 11th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2018, SciTePress, 2018, p. 141-149Conference paper (Refereed)
    Abstract [en]

    Open Source Medical Devices may be part of the solution towards the democratization of medical technologies pursuing Universal Health Coverage as part of the Sustainable Development Goals for United Nations. Recent technological advances, especially in information and communication technologies, combined with innovative collaborative design methodologies and manufacturing techniques allow for the mass-personalization of biodevices and help to optimize the related development times and costs, while keeping safety in the foreground through the whole life cycle of medical products. These advantages can be further promoted by adequately fostering collaboration, communication, high value information exchange, and sustainable partnerships and by extending the employment of open source strategies. To this end, within the UBORA project, we are developing a framework for training the biomedical engineers of the future in open-source collaborative design strategies and for supporting the sharing of information and the assessment of safety and efficacy in novel biodevices. An essential part of this open-source collaborative framework is the UBORA e-infrastructure, which is presented in this study, together with some initial success cases. Main future challenges, connected with regulatory harmonization, with educational issues and with accessible and open design and manufacturing resources, among others, are also presented and discussed.

  • 14.
    Ahluwalia, Arti
    et al.
    Univ Pisa, Dept Ingn Informaz, Bioengn, Pisa, Italy..
    De Maria, Carmelo
    Univ Pisa, Dept Ingn Informaz, Bioengn, Pisa, Italy..
    Diaz Lantada, Andres
    UPM, ETSII, Dept Mech Engn, Madrid, Spain..
    Madete, June
    Univ Pisa, Res Ctr E Piaggio, Pisa, Italy.;Kenyatta Univ, Nairobi, Kenya..
    Makobore, Philippa Ngaju
    Uganda Ind Res Inst, Instrumentat Div, Kampala, Uganda..
    Ravizza, Alice
    Univ Pisa, Pisa, Italy..
    Di Pietro, Licia
    Mridha, Mannan
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Munoz-Guijosa, Juan Manuel
    UPM, ETSII, Dept Mech Engn, Madrid, Spain..
    Tanarro, Enrique Chacon
    UPM, ETSII, Dept Mech Engn, Madrid, Spain..
    Torop, Janno
    Tartu Ulikool, Inst Technol, Tartu, Estonia..
    Biomedical Engineering Project Based Learning: Euro-African Design School Focused on Medical Devices2018In: International Journal of Engineering Education, ISSN 0949-149X, Vol. 34, no 5, p. 1709-1722Article in journal (Refereed)
    Abstract [en]

    Biomedical engineering (BME) has the potential of transforming medical care towards universal healthcare by means of the democratization of medical technology. To this end, innovative holistic approaches and multidisciplinary teams, built upon the gathering of international talent, should be encouraged within the medical industry. However, these transformations can only be accomplished if BME education also continuously evolves and focuses on the internationalization of students, the promotion of collaborative design strategies and the orientation towards context relevant medical needs. In this study we describe an international teaching-learning experience, the "UBORA (Swahili for 'excellence') Design School". During an intensive week of training and collaboration 39 engineering students lived through the complete development process for creating innovative open-source medical devices following the CDIO ("conceivedesign-implement-operate") approach and using the UBORA e-infrastructure as a co-design platform. Our post-school survey and analyses showed that this integral teaching-learning experience helped to promote professional skills and could nurture the future generation of biomedical engineers, who could transform healthcare technology through collaborative design oriented to open source medical devices.

  • 15. Ahmad, Amais
    et al.
    Pepin, Xavier
    Aarons, Leon
    Wang, Yuya
    Darwich, Adam S.
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Wood, J. Matthew
    Tannergren, Christer
    Karlsson, Eva
    Patterson, Claire
    Thörn, Helena
    Ruston, Linette
    Mattinson, Alex
    Carlert, Sara
    Berg, Staffan
    Murphy, Donal
    Engman, Helena
    Laru, Johanna
    Barker, Ric
    Flanagan, Talia
    Abrahamsson, Bertil
    Budhdeo, Shanoo
    Franek, Frans
    Moir, Andrea
    Hanisch, Gunilla
    Pathak, Shriram M.
    Turner, David
    Jamei, Masoud
    Brown, Jonathan
    Good, David
    Vaidhyanathan, Shruthi
    Jackson, Claire
    Nicolas, Olivier
    Beilles, Stephane
    Nguefack, Jean-Flaubert
    Louit, Guillaume
    Henrion, Louis
    Ollier, Celine
    Boulu, Laurent
    Xu, Christine
    Heimbach, Tycho
    Xiojun, Ren
    Lin, Wen
    Nguyen-Trung, Anh-Thu
    Zhang, Jin
    He, Handan
    Wu, Fan
    Bolger, Michael B.
    Mullin, James M.
    van Osdol, Bill
    Szeto, Ke
    Korjamo, Timo
    Pappinen, Sari
    Tuunainen, Johanna
    Zhu, Wei
    Xia, Binfeng
    Daublain, Pierre
    Wong, Suet
    Manthena, Varma
    Modi, Sweta
    Schäfer, Kerstin Julia
    Schmid, Katrin
    Lloyd, Richard
    Patel, Aarti
    Tistaert, Christophe
    Bevernage, Jan
    Nguyen, Mai Anh
    Lindley, David
    Carr, Robert
    Rostami-Hodjegan, Amin
    IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 4: Prediction accuracy and software comparisons with improved data and modelling strategies2020In: European journal of pharmaceutics and biopharmaceutics, ISSN 0939-6411, E-ISSN 1873-3441, Vol. 156, p. 50-63Article in journal (Refereed)
    Abstract [en]

    Oral drug absorption is a complex process depending on many factors, including the physicochemical properties of the drug, formulation characteristics and their interplay with gastrointestinal physiology and biology. Physiological-based pharmacokinetic (PBPK) models integrate all available information on gastro-intestinal system with drug and formulation data to predict oral drug absorption. The latter together with in vitro-in vivo extrapolation and other preclinical data on drug disposition can be used to predict plasma concentration-time profiles in silico. Despite recent successes of PBPK in many areas of drug development, an improvement in their utility for evaluating oral absorption is much needed. Current status of predictive performance, within the confinement of commonly available in vitro data on drugs and formulations alongside systems information, were tested using 3 PBPK software packages (GI-Sim (ver.4.1), Simcyp® Simulator (ver.15.0.86.0), and GastroPlusTM (ver.9.0.00xx)). This was part of the Innovative Medicines Initiative (IMI) Oral Biopharmaceutics Tools (OrBiTo) project.

    Fifty eight active pharmaceutical ingredients (APIs) were qualified from the OrBiTo database to be part of the investigation based on a priori set criteria on availability of minimum necessary information to allow modelling exercise. The set entailed over 200 human clinical studies with over 700 study arms. These were simulated using input parameters which had been harmonised by a panel of experts across different software packages prior to conduct of any simulation. Overall prediction performance and software packages comparison were evaluated based on performance indicators (Fold error (FE), Average fold error (AFE) and absolute average fold error (AAFE)) of pharmacokinetic (PK) parameters.

    On average, PK parameters (Area Under the Concentration-time curve (AUC0-tlast), Maximal concentration (Cmax), half-life (t1/2)) were predicted with AFE values between 1.11 and 1.97. Variability in FEs of these PK parameters was relatively high with AAFE values ranging from 2.08 to 2.74. Around half of the simulations were within the 2-fold error for AUC0-tlast and around 90% of the simulations were within 10-fold error for AUC0-tlast. Oral bioavailability (Foral) predictions, which were limited to 19 APIs having intravenous (i.v.) human data, showed AFE and AAFE of values 1.37 and 1.75 respectively. Across different APIs, AFE of AUC0-tlast predictions were between 0.22 and 22.76 with 70% of the APIs showing an AFE > 1. When compared across different formulations and routes of administration, AUC0-tlast for oral controlled release and i.v. administration were better predicted than that for oral immediate release formulations. Average predictive performance did not clearly differ between software packages but some APIs showed a high level of variability in predictive performance across different software packages. This variability could be related to several factors such as compound specific properties, the quality and availability of information, and errors in scaling from in vitro and preclinical in vivo data to human in vivo behaviour which will be explored further. Results were compared with previous similar exercise when the input data selection was carried by the modeller rather than a panel of experts on each in vitro test. Overall, average predictive performance was increased as reflected in smaller AAFE value of 2.8 as compared to AAFE value of 3.8 in case of previous exercise.

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  • 16.
    Ahmed, Redve
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Migration from Manual to Automatic Regression Testing: Best practices for Salesforce Test Automation2023Independent thesis Basic level (university diploma), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The goal of this thesis is to explore the possibility on if it is possible to automate regression testing for a SaaS application with a serverless approach. The thesis covers the fundamentals of the software development lifecycle, cloud concepts, different types of testing frameworks, and SaaS applications. The report researches various testing tools that can be used in accordance with Polestar’s needs. The testing framework must run the existing tests and deliver the results of the tests. The system must be able to coexist with the testing strategy that is in place today. The result is a testing framework that can run a number of selected tests on the SaaS application Salesforce. The system was deployed with serverless docker containers through Amazon Web Services. The report also covers what a future implementation can look like and potential improvements. 

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    Migration from Manual to Automatic Regression Testing
  • 17.
    Al Khateeb, Ahmad
    et al.
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Summaq, Abdulrazzaq
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Securing Data in a Cloud Environment: Access Control, Encryption, and Immutability2023Independent thesis Basic level (university diploma), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The amount of data and the development of new technologies used by all society-critical organizations are increasing dramatically. In parallel, data breaches, cyber-attacks, and their devastating consequences are also on the rise, as well as the number of individuals and organizations that are potential targets for such attacks. This places higher demands on security in terms of protecting data against cyber-attacks and controlling access to data that authenticated users want to access. The paper focuses on studying concepts of secure data practices in a GitLab-based cloud environment. The objective is to give answers to questions such as how to ensure the guarantee of secure data and protect it from unauthorized access and changes. The work behind this thesis includes exploring techniques for access control, data encryption, and data immutability. The study is followed by an implementation project that includes fetching code from GitLab verifying user identity and access control, managing data access, and displaying the results. The results of the thesis demonstrate the effectiveness of the implemented security measures in protecting data and controlling access.

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    Examensarbetesrapport
  • 18.
    Albaaj, Hussein
    et al.
    Department of Global Public Health, Karolinska Institutet, Solna, Sweden.
    Attergrim, Jonatan
    Department of Global Public Health, Karolinska Institutet, Solna, Sweden; Perioperative Medicine and Intensive Care, Karolinska University Hospital, Solna, Sweden.
    Strömmer, Lovisa
    Division of Surgery, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden.
    Brattström, Olof
    Perioperative Medicine and Intensive Care, Karolinska University Hospital, Solna, Sweden; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
    Jacobsson, Martin
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Wihlke, Gunilla
    Trauma and Reparative Medicine, Karolinska University Hospital, Solna, Sweden.
    Västerbo, Liselott
    Trauma and Reparative Medicine, Karolinska University Hospital, Solna, Sweden.
    Joneborg, Elias
    Department of Global Public Health, Karolinska Institutet, Solna, Sweden.
    Gerdin Wärnberg, Martin
    Department of Global Public Health, Karolinska Institutet, Solna, Sweden; Perioperative Medicine and Intensive Care, Karolinska University Hospital, Solna, Sweden.
    Patient and process factors associated with opportunities for improvement in trauma care: a registry-based study2023In: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, E-ISSN 1757-7241, E-ISSN 1757-7241, Vol. 31, no 1, article id 87Article in journal (Refereed)
    Abstract [en]

    Background Trauma is one of the leading causes of morbidity and mortality worldwide. Morbidity and mortality review of selected patient cases is used to improve the quality of trauma care by identifying opportunities for improvement (OFI). The aim of this study was to assess how patient and process factors are associated with OFI in trauma care.

    Methods We conducted a registry-based study using all patients between 2017 and 2021 from the Karolinska University Hospital who had been reviewed regarding the presence of OFI as defined by a morbidity and mortality conference. We used bi- and multivariable logistic regression to assess the associations between the following patient and process factors and OFI: age, sex, respiratory rate, systolic blood pressure, Glasgow Coma Scale (GCS), Injury Severity Score (ISS), survival at 30 days, highest hospital care level, arrival on working hours, arrival on weekends, intubation status and time to first computed tomography (CT).

    Results OFI was identified in 300 (5.8%) out of 5182 patients. Age, missing Glasgow Coma Scale, time to first CT, highest hospital care level and ISS were statistically significantly associated with OFI.

    Conclusion Several patient and process factors were found to be associated with OFI, indicating that patients with moderate to severe trauma and those with delays to first CT are at the highest odds of OFI.

  • 19.
    Albaloua, Mark
    et al.
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Kizilkaya, Kenan
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Användning av högnivåspråket Swift i webbläsaren och i Android: En studie på möjligheterna att återanvända högnivåspråket Swift utanför iOS i andra plattformar som webbläsare och Android2023Independent thesis Basic level (university diploma), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The purpose of this work was to study the possibilities of using the high-level language Swift outside of iOS in the browser and on Android. This is to reduce the amount of code written thus reducing development time to create applications for iOS, browser, and Android. To find suitable tools to solve the problem, a study on previous works and methods has been made. The results of the study led to the use of the framework Tokamak together with WebAssembly to reuse Swift in the browser and the tool SwiftKotlin to reuse Swift on Android.

    An application using the Model-View-ViewModel (MVVM) design pattern was created with the intention of testing reusability. The results showed that Tokamak with WebAssembly made it possible to use all the code from the original iOS application except platform-specific functions such as local saving and network calls. SwiftKotlin made it possible to reuse the model class with some small adjustments while the viewmodel and view classes must be manually written. 

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  • 20.
    Aldahan, Leith
    et al.
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Kudoori, Ivan
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Utvärdering av roterande borstlösfrekvensomformare tillspårledningar2019Independent thesis Basic level (university diploma), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Track lines are used in subway stations to show the train locations and determine the speed of the train by chopping the frequency. The frequency of the track lines is obtained from a rotary frequency converter. In today's stations, rotary frequency converters with brushes are commonly used. These emit a great deal of heat in some relays and produce environmental problems in the form of carbon dust from the brushes. The existing systems have been used for over 30 years and obtaining spare parts and conducting maintenance on the systems can be difficult.

    This degree project examines the possibility of newer systems being built on a rotating brushless frequency converter, where the spare parts and servicing would be available for at least the next 25 years.

    The project surveys and compares different rotating brushless frequency converters from different suppliers to find an identical frequency converter to meet the requirements of the Traffic Administration.

    The result of this study has had a lot of focus on the problem area with the brushed frequency converter that produces harmful substances such as carbon dust and the heat in the relay room. Discussions with manufacturing companies of rotating brushless frequency converters have been made during this study where possible options were discussed for further development of the system in relay rooms. The result has also discussed the possibilities of using the new system of frequency converters with brushless motor and generator instead of the current brushed frequency converter available in the facility. The result has also shown that the rotating brushless frequency converter can convert the frequency to 75 Hz. The new system meets RAMS requirements of the Trafikförvaltning, and the system lasts for at least 25 years. This was a major requirement of the Trafikförvaltning, which was fulfilled during this study.

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    Utvärdering av roterande borstlös fre-kvensomformare till spårledningar
  • 21.
    Alfrijat, Christopher
    et al.
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Eriksson, Rasmus
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Analys och utvärdering av LED-belysning i Stockholms tunnelbana2019Independent thesis Basic level (university diploma), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Trafikförvaltningen, responsible for public transport in Stockholm, has started a project to replace existing luminaires in the subway of Stockholm to LED lights. This thesis could be a basis for an upcoming procurement.

    In this report, various models of LED lights technical specifications will be evaluated based on the environmental requirements in Stockholm’s subway, where the existing luminaires will be replaced. For this environment, there is no standard regarding LED lights today. With the help of literature studies and tests, a groundwork for a specification could be made. The tests were only made on a selection of LED lights and their technical specifications were presented. All luminaires passed the EMC (electromagnetic compatibility) tests that were made in order to determine any interference with Stockholm’s public transport (SL) radio communication system.

    Environmental aspects and economical aspects of the implementation of LED lights has been taken into consideration.

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  • 22.
    Ali, Umar
    et al.
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Sulaiman, Rabi
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Using UX design principles for comprehensive data visualisation2023Independent thesis Basic level (university diploma), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Workplace safety, particularly in manual handling tasks, is a critical concern that hasbeen increasingly addressed using advanced risk assessment tools. However, pre-senting the complex results of these assessments in an easily digestible format re-mains a challenge. This thesis focused on designing and developing a user-friendlyweb application to visualise risk assessment data effectively. Grounded in a robusttheoretical framework that combines user experience principles, and data visualisa-tion techniques. The study employed an iterative, user-centric design process to de-velop the web application. Multiple visualisation methods, such as pie charts for vis-ualising risk distribution, bar chart, and line chart for time-based analysis, were eval-uated for their effectiveness through usability testing. The application's primary con-tribution lies in its efficient data visualisation techniques, aimed at simplifying com-plex datasets into actionable insights. This work lays the groundwork enabling futuredevelopment by pinpointing areas for improvement like enhanced interactivity andaccessibility.

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  • 23.
    Alkass, Jakob
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    UX spelar roll: Förbättra prestanda hos webbsida för förbättrad användarupplevelse av webbapplikation.2022Independent thesis Basic level (university diploma), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The company Telia has a web application that is under development and will serve as an internal portal for clients of the company. They experience a lack of performance in the frontend part of the application in the form of long loading times. They therefore want to explore possibilities for optimizing the performance of their web application in hope of improving the user experience. The goal was to investigate possibilities for the application of different optimization techniques that can improve parts of the performance with close connection to the user experience.

    For this thesis, previous research was examined in the field of user experience related to digital products. Research of similar work such as appropriate performance measures and optimization techniques was also conducted. To test, analyse and evaluate the optimization techniques, automatic tests were created that stored measurement data on selected performance metrics. Measurement data from the tests was then analysed in order to suggest further development for Telia’s web application. An analysis of the measurement data showed an overall improvement in Telia’s web application performance for the two examined performance metrics by 33% and 35%respectively. 

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    Examensarbete_rapport
  • 24.
    Al-Khamisi, Ardoan
    et al.
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    El Khoury, Christian
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    AI i rekryteringsprocessen: En studie om användningen av AI för CV-analys2024Independent thesis Basic level (university diploma), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The study examines which methods are most suitable for recruitment processes by including three existing artificial intelligence AI-tools as well as a custom-developed prototype. Previous studies have shown that AI can improve recruitment processes by increasing efficiency and reducing biases, but also that there are limitations in how well AI can assess candidate’s competencies. The goal is to determine the most effective AI solutions for matching qualified candidates to leading positions. Opportunities for improvement in speed, accuracy, and quality of the recruitment process have been identified. The focus of this work is on analyzing existing AI-solutions in parallel with the development and testing of a prototype. The prototype has been designed to address the deficiencies identified in existing methods, such as matching keywords between Curriculum Vitae (CV) and job advertisements. This method has limitations in how well it can identify candidate’s real competencies and relevance for the job, which is explored in this study. The results from this study show that AI currently has a limited, but growing significance in recruitment processes. This points to significant potential for AI to provide new solutions that can lead to fairer and more efficient recruitment processes in the future.

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    AI i rekryteringsprocessen
  • 25.
    Alkurdi, Yaman
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Prestandajämförelse mellan Apache Kafka och Redpanda för realtidsdataapplikationer inom Internet of Things2024Independent thesis Basic level (university diploma), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    There is a lack of independent research comparing the capacity of Redpanda to established alternatives like Apache Kafka, particularly in IoT contexts where resource efficiency is critical. This thesis compares the performance of the two platforms in real-time data applications under conditions similar to those in IoT environments. Through a custom-developed application, performance tests were conducted in a local containerized environment to evaluate throughput and latency across various message sizes and partition counts. The study finds that Redpanda outperforms Kafka with smaller message sizes, offering higher throughput and lower latency, particularly at higher partition counts. Conversely, Kafka excels with larger message sizes, achieving higher throughput but with increased latency. The results indicate that Redpanda is well-suited for IoT applications requiring rapid handling of small messages, while Kafka is more efficient for scenarios involving larger data volumes. The findings emphasize the importance of selecting the appropriate platform based on specific application needs, thus contributing valuable insights in IoT and real-time data streaming.

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    Prestandajämförelse mellan Apache Kafka och Redpanda för realtidsdataapplikationer inom Internet of Things
  • 26.
    Almosawi, Talib
    et al.
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Karanta, George
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    ZigBee-based climate measurement system for thermal comfort in traffic busses2021Independent thesis Basic level (university diploma), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    This thesis describes the work process two (WP2) of a project led by the traffic administration in Stockholm to achieve the passengers' thermal comfort in traffic buses. 

    The purpose of this thesis is to design and implement a measurement system comprised in eight measurement position in a bus. Each position is able to transmit data using a wireless communication protocol, with a central unit collecting all the transmitted data taking into consideration the accuracy of the measurements and filtering out the incorrect data.

    In order to accomplish this, a literature study is conducted investigating different measurement methods for different parameters, different communication protocols were analysed as well to determine an appropriate communication protocol suitable for climate measurement in a bus environment with passengers present on board. 

    The output of the HVAC system is also required to help the traffic administration demonstrate the results of adjusting the temperature in the bus to reach the thermal comfort and how it led to saving energy.

    The system incorporates ZigBee , ESP32 microcontroller in the sender positions and a Raspberry pi operating as a central unit to collect data and store it in a file system providing an accurate data that will help the traffic administration achieve their goals.

    Unfortunately, there were some diffculties accessing CAN system data to provide the output of the HVAC system.

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    ZigBee-based climate measurement system for thermal comfort in traffic busses
  • 27.
    Al-Robaye, Ali
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Svenska laddningsinfrastrukturen: Studie om hur den svenska laddningsinfrastrukturen måste utvecklas för att kunna tillgodose en fortsatt omställning av fossildrivna fordon till elektriska.2024Independent thesis Basic level (university diploma), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The entire world is confronting new challenges as a result of climate change. To mitigate human impact on the climate, the European Union and Sweden, as an EU member state, have decided to phase out the use of fossil fuels. The transition from fossil-fueled vehicles to electric ones has commenced, but Sweden is currently far from achieving a complete transition. The prerequisite for a complete transition is the establishment of a functional charging infrastructure capable of handling the increasing demand for charging. This report examines the current state of the Swedish charging infrastructure, highlights the factors hindering further development, and concludes by outlining the necessary steps for the Swedish charging infrastructure to facilitate transitions of 50-, 75-, and 100-percent from fossil-fueled to electric vehicles. Based on this analysis, it is evident that investments in public and home charging are critical factors at all levels of transition. Transparency and collaboration are currently lacking but are essential elements that must be in place for a successful and complete transition.

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    Ali_A_EX
  • 28.
    Al-Wendawi, Kamal
    et al.
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Faradj, Dyar
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Smartare resursfördelning med hjälp av djup maskininlärning2020Independent thesis Basic level (university diploma), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    AbstractThis thesis has been carried out on behalf of Stanley Security Sverige AB. The company Stanley provides a product to calculate the number of people in a queue. The product detects the number of people in a queue with the help of a surveillance camera and deep machine learning. They find that the existing solution does not perform well enough to be deployed and does not detect with high accuracy. In this work, various known object recognition models have been examined and compared, as well as examination of previous work and tests in the field.The result was a reconfigured model prototype that only detected faces in comparison to known models You Only Look Once V3 (YOLOV3) and Single Shot MultiBox Detector (SSD) that detect the entire human body, in addition to other objects. The proposed model performed significantly better than the known models and had higher accuracy. The results indicate that the proposed model prototype can be deployed in real time and be used by Stanely's customers to efficiently allocate resources within their companies.Keywordsmachine learning, image analysis, Python, Darknet, neural network, deep learning, YOLOV3, Single Shot MultiBox Detector.

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  • 29.
    Alyoussef, Elyas
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Kategorisering på uppfattningar om digitala hot på webbapplikationer: Med en studie som visar de ekonomiska konsekvenserna av cyberattacker2022Independent thesis Basic level (university diploma), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    This thesis presents a categorization of conceptions about digital threats on web applications with a study showing the economic consequences of cyber-attacks. The aim of this thesis is to contribute to a scientific article, which can be valuable to the public, as well as for future work and employment.

    Constant comparison method was used to analyse aggregate perceptions. The results reveal several exciting findings for theory and practice, where perceptions of the cyber world were presented in order to understand more how others see cybersecurity today. It also shows significant variations among the participants' perceptions. This shows that information security, even if it is gradually developed, has a long way to go until it becomes an unbroken part of the business. 

    This study can also serve as a guide for the different perceptions of cyber-attacks as it provides an overview of the most relevant cyber-attacks today. This thesis was supplemented with a study that highlights the economic consequences of cyberattacks. In addition to this, the cyber-attack on Coop during the summer of 2021 was also studied. 

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    Elyas_Examensarbete
  • 30.
    Aminoff, Hedvig
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Unpacking the Sociotechnical Complexity of a Surgical Setting: Capturing the Context of Use to Inform Design and Evaluation2022Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    This thesis focuses on how the implementation context for a surgical telementoringservice can be understood as a complex, adaptive sociotechnical system.Teleguidance was a service for remote surgical consultation in Endoscopic RetrogradeCholangiopancreatography (ERCP), a highly specialized clinical procedure.The solution had been developed in a participatory design setting andhad also been successfully trialed in a pilot study. It was to be deployed atfour additional hospitals, but differences between the implementation contextswould make it challenging to understand clinical outcomes, and could also affectmatters such as adoption.This thesis includes four papers which converge on user needs and the sociotechnicalimplementation context for teleguidance. The aim was to demonstratehow a sociotechnical systems oriented approach could be used to identifyfactors that could interact with the implementation. The first paper describesan investigation of attitudes and expectations among end-users and other stakeholders.The second paper shows how modelling the sociotechnical work systemmade it possible to investigate and proactively identify issues that might influenceimplementation and adoption. The third paper explicates methodologicalaspects of modeling the domain. The fourth paper describes a study designed tocapture early reactions to working with the system. Seen together, the researchrepresents a design science approach, that proposes that the implementationcontext can be viewed as a complex, adaptive system, and provides examplesthat show how focusing on user and stakeholder needs and wider context ofuse is a viable approach for supporting the implementation and evaluation oftelemedicine systems in complex settings.

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    fulltext kappa
  • 31.
    Aminoff, Hedvig
    et al.
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems.
    Meijer, Sebastiaan
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Context and Complexity in Telemedicine Evaluation: Work Domain Analysis in a Surgical Setting2021In: JMIR Perioperative Medicine, E-ISSN 2561-9128, Vol. 4, no 2, p. e26580-e26580Article in journal (Refereed)
    Abstract [en]

    Many promising telemedicine innovations fail to be accepted and used over time, and there are longstanding questions about howto best evaluate telemedicine services and other health information technologies. In response to these challenges, there is a growinginterest in how to take the sociotechnical complexity of health care into account during design, implementation, and evaluation.This paper discusses the methodological implications of this complexity and how the sociotechnical context holds the key tounderstanding the effects and outcomes of telemedicine. Examples from a work domain analysis of a surgical setting, where atelemedicine service for remote surgical consultation was to be introduced, are used to show how abstracted functional modelingcan provide a structured and rigorous means to analyze and represent the implementation context in complex health care settings.

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  • 32.
    Aminoff, Hedvig
    et al.
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Meijer, Sebastiaan
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Arnelo, Urban
    Groth, Kristina
    Modeling the Implementation Context of a Telemedicine Service: Work Domain Analysis in a Surgical Setting2021In: JMIR Formative Research, E-ISSN 2561-326X, Vol. 6, no 5, article id e26505Article in journal (Refereed)
    Abstract [en]

    Background:A telemedicine service enabling remote surgical consultation had shown promising results. When the service was to be scaled up, it was unclear how contextual variations among different clinical sites could affect the clinical outcomes and implementation of the service. It is generally recognized that contextual factors and work system complexities affect the implementation and outcomes of telemedicine. However, it is methodologically challenging to account for context in complex health care settings. We conducted a work domain analysis (WDA), an engineering method for modeling and analyzing complex work environments, to investigate and represent contextual influences when a telemedicine service was to be scaled up to multiple hospitals.

    Objective:We wanted to systematically characterize the implementation contexts at the clinics participating in the scale-up process. Conducting a WDA would allow us to identify, in a systematic manner, the functional constraints that shape clinical work at the implementation sites and set the sites apart. The findings could then be valuable for informed implementation and assessment of the telemedicine service.

    Methods:We conducted observations and semistructured interviews with a variety of stakeholders. Thematic analysis was guided by concepts derived from the WDA framework. We identified objects, functions, priorities, and values that shape clinical procedures. An iterative “discovery and modeling” approach allowed us to first focus on one clinic and then readjust the scope as our understanding of the work systems deepened.

    Results:We characterized three sets of constraints (ie, facets) in the domain: the treatment facet, administrative facet (providing resources for procedures), and development facet (training, quality improvement, and research). The constraints included medical equipment affecting treatment options; administrative processes affecting access to staff and facilities; values and priorities affecting assessments during endoscopic retrograde cholangiopancreatography; and resources for conducting the procedure.

    Conclusions:The surgical work system is embedded in multiple sets of constraints that can be modeled as facets of the system. We found variations between the implementation sites that might interact negatively with the telemedicine service. However, there may be enough motivation and resources to overcome these initial disruptions given that values and priorities are shared across the sites. Contrasting the development facets at different sites highlighted the differences in resources for training and research. In some cases, this could indicate a risk that organizational demands for efficiency and effectiveness might be prioritized over the long-term outcomes provided by the telemedicine service, or a reduced willingness or ability to accept a service that is not yet fully developed or adapted. WDA proved effective in representing and analyzing these complex clinical contexts in the face of technological change. The models serve as examples of how to analyze and represent a complex sociotechnical context during telemedicine design, implementation, and assessment.

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  • 33.
    Aminoff, Hedvig
    et al.
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Meijer, Sebastiaan
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Frennert, Susanne
    Department of Computer Science and Media Technology, Internet of Things and People Research Center, Malmö University, Malmö, Sweden.
    Telemedicine for Remote Surgical Guidance in Endoscopic Retrograde Cholangiopancreatography: Mixed Methods Study of Practitioner Attitudes2021In: JMIR Formative Research, E-ISSN 2561-326X, Vol. 5, no 1, p. e20692-e20692Article in journal (Refereed)
    Abstract [en]

    Background:Telemedicine innovations are rarely adopted into routine health care, the reasons for which are not well understood. Teleguidance, a promising service for remote surgical guidance during endoscopic retrograde cholangiopancreatography (ERCP) was due to be scaled up, but there were concerns that user attitudes might influence adoption.

    Objective:Our objective was to gain a deeper understanding of ERCP practitioners’ attitudes toward teleguidance. These findings could inform the implementation process and future evaluations.

    Methods:We conducted semistructured interviews with ERCP staff about challenges during work and beliefs about teleguidance. Theoretical constructs from the technology acceptance model (TAM) guided the thematic analysis. Our findings became input to a 16-item questionnaire, investigating surgeons’ beliefs about teleguidance’s contribution to performance and factors that might interact with implementation.

    Results:Results from 20 interviews with ERCP staff from 5 hospitals were used to adapt a TAM questionnaire, exchanging the standard “Ease of Use” items for “Compatibility and Implementation Climate.” In total, 23 ERCP specialists from 15 ERCP clinics responded to the questionnaire: 9 novices (<500 ERCP procedures) and 14 experts (>500 ERCP procedures). The average agreement ratings for usefulness items were 64% (~9/14) among experts and 75% (~7/9) among novices. The average agreement ratings for compatibility items were somewhat lower (experts 64% [~9/14], novices 69% [~6/9]). The averages have been calculated from the sum of several items and therefore, they only approximate the actual values. While 11 of the 14 experts (79%) and 8 of the 9 novices (89%) agreed that teleguidance could improve overall quality and patient safety during ERCP procedures, only 8 of the 14 experts (57%) and 6 of the 9 novices (67%) agreed that teleguidance would not create new patient safety risks. Only 5 of the 14 experts (36%) and 3 of the 9 novices (33%) were convinced that video and image transmission would function well. Similarly, only 6 of the 14 experts (43%) and 6 of the 9 novices (67%) agreed that administration would work smoothly. There were no statistically significant differences between the experts and novices on any of the 16 items (P<.05).

    Conclusions:Both novices and experts in ERCP procedures had concerns that teleguidance might disrupt existing work practices. However, novices were generally more positive toward teleguidance than experts, especially with regard to the possibility of developing technical skills and work practices. While newly trained specialists were the main target for teleguidance, the experts were also intended users. As experts are more likely to be key decision makers, their attitudes may have a greater relative impact on adoption. We present suggestions to address these concerns. We conclude that using the TAM as a conceptual framework can support user-centered inquiry into telemedicine design and implementation by connecting qualitative findings to well-known analytical themes.

  • 34.
    Aminoff, Hedvig
    et al.
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems.
    Meijer, Sebastiaan
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Groth, Kristina
    Arnelo, Urban
    User Experience in Remote Surgical Consultation: Survey Study of User Acceptance and Satisfaction in Real-Time Use of a Telemedicine Service2021In: JMIR Human Factors, E-ISSN 2292-9495, E-ISSN 2292-9495, Vol. 8, no 4, p. e30867-e30867Article in journal (Refereed)
    Abstract [en]

    Background: Teleguidance, a promising telemedicine service for intraoperative surgical consultation, was planned to scale upat a major academic hospital in partnership with 5 other hospitals. If the service was adopted and used over time, it was expectedto provide educational benefits and improve clinical outcomes during endoscopic retrograde cholangiopancreatography (ERCP),which is a technically advanced procedure for biliary and pancreatic disease. However, it is known that seemingly successfulinnovations can play out differently in new settings, which might cause variability in clinical outcomes. In addition, few telemedicineservices survive long enough to deliver system-level outcomes, the causes of which are not well understood.Objective: We were interested in factors related to usability and user experience of the telemedicine service, which might affectadoption. Therefore, we investigated perceptions and responses to the use and anticipated use of a system. Technology acceptance,a construct referring to how users perceive a technology’s usefulness, is commonly considered to indicate whether a new technologywill actually be used in a real-life setting. Satisfaction measures were used to investigate whether user expectations and needshave been met through the use of technology. In this study, we asked surgeons to rate the perceived usefulness of teleguidance,and their satisfaction with the telemedicine service in direct conjunction with real-time use during clinical procedures.Methods: We designed domain-specific measures for perceived usefulness and satisfaction, based on performance and outcomemeasures for the clinical procedure. Surgeons were asked to rate their user experience with the telemedicine service in directconjunction with real-time use during clinical procedures.Results: In total, 142 remote intraoperative consultations were conducted during ERCP procedures at 5 hospitals. The demandfor teleguidance was more pronounced in cases with higher complexity. Operating surgeons rated teleguidance to have contributedto performance and outcomes to a moderate or large extent in 111 of 140 (79.3%) cases. Specific examples were that teleguidancewas rated as having contributed to intervention success and avoiding a repeated ERCP in 23 cases, avoiding 3 PTC, and 11referrals, and in 11 cases, combinations of these outcomes. Preprocedure beliefs about the usefulness of teleguidance weregenerally lower than postprocedure satisfaction ratings. The usefulness of teleguidance was mainly experienced through practicaladvice from the consulting specialist (119/140, 85%) and support with assessment and decision-making (122/140, 87%).Conclusions: Users’ satisfaction with teleguidance surpassed their initial expectations, mainly through contribution to nontechnicalaspects of performance, and through help with general assessment. Teleguidance shows the potential to improve performance and outcomes during ERCP. However, it takes hands-on experience for practitioners to understand how the new telemedicineservice contributes to performance and outcomes.

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  • 35.
    Andersson, Julius
    et al.
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Engström, David
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    A study in how to inject steganographic data into videos in a sturdy and non-intrusive manner2019Independent thesis Basic level (university diploma), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    It is desirable for companies to be able to hide data inside videos to be able to find the source of any unauthorised sharing of a video. The hidden data (the payload) should damage the original data (the cover) by an as small amount as possible while also making it hard to remove the payload without also severely damaging the cover. It was determined that the most appropriate place to hide data in a video was in the visual information, so the cover is an image. Two injection methods were developed and three methods for attacking the payload. One injection method changes the pixel values of an image directly to hide the payload and the other transforms the image to cosine waves that represented the image and it then changes those cosine waves to hide the payload. Attacks were developed to test how hard it was to remove the hidden data. The methods for attacking the payload where to add and remove a random value to each pixel, to set all bits of a certain importance to 1 or to compress the image with JPEG. The result of the study was that the method that changed the image directly was significantly faster than the method that transformed the image and it had a capacity for a larger payload. The injection methods protected the payload differently well against the various attacks so which method that was the best in that regard depends on the type of attack.

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    A study in how to inject steganographic data into videos in a sturdy and non-intrusive manner
  • 36.
    Andstén, Björn
    et al.
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Taha, Sava
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    En jämförelse mellan Apples djupkamerateknik och goniometern2021Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Today, movement measurements are made manually in healthcare using a goniometer. The measurements are often time-consuming and specially trained practitioners are needed, furthermore the readings are dependent on the practitioner's eye measurements. New technology has been introduced to make the same measurements using external sensors which have the disadvantage that they can be costly and space consuming. Recently, depth camera technology has introduced an alternative solution to make it more efficient for both patients and practitioners. The purpose of this study is to investigate whether Apple depth camera technology can replace current technology by being able to perform motion measurements with only one Ipad/Iphone with a built-in depth camera. For this, a prototype has been developed to be able to automatically calculate medically relevant angles by filming a person. Various motion measurements have been performed and the measurement results have been analysed. Apple depth camera has high precision in the measured values. However, a larger study needs to be performed in order to be able to determine whether Apple's depth camera could replace current technology.

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  • 37.
    Asbai, Ali
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Prestanda- och användbarhetsanalys av decentraliserad ledger-teknik utvecklad med antingen SQL eller Blockkedja2022Independent thesis Basic level (university diploma), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    B-SPORT+ is a project that was interested in developing an application for advice and guidance in regards to physical exercise adapted for people with disabilities. B-SPORT+ identified the need for a decentralized ledger in the application. A decentralized ledger is a register that stores data on transactions performed in an application. In previous work on the application, a Blockchain was highlighted as a possible solution. However, B-SPORT+ experienced that this technology contained disadvantages such as high energy consumption and expensive implementation. Therefore, this work investigated, developed and evaluated an alternative to Blockchain using relational databases.

    The result was two prototypes. The first prototype mimicked Blockchain technology by horizontally fragmenting a relational database that stored a table of performed transactions. Then, cryptographic hashing was used to validate transactions between database fragments. A prototype was also developed using Blockchain technology, this prototype was used to evaluate the first prototype. The evaluation showed that the structure of the SQL prototype reduced memory utilization in user computers it also reduced energy consumption and time when performing transactions. This structure also allowed moderation of data in the ledger, which was vital for the application BSPORT + wanted to develop. 

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  • 38.
    Assander, Susanne
    et al.
    Karolinska Inst, Div Occupat Therapy, Dept Neurobiol Caring Sci & Soc, Stockholm, Sweden..
    Bergström, Aileen
    Karolinska Inst, Div Occupat Therapy, Dept Neurobiol Caring Sci & Soc, Stockholm, Sweden..
    Eriksson, Christina
    Karolinska Inst, Div Occupat Therapy, Dept Neurobiol Caring Sci & Soc, Stockholm, Sweden.;Acad Primary Hlth Care Ctr, Stockholm, Sweden..
    Meijer, Sebastiaan
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Guidetti, Susanne
    Karolinska Inst, Div Occupat Therapy, Dept Neurobiol Caring Sci & Soc, Stockholm, Sweden.;Karolinska Univ Hosp, Med Unit Occupat Therapy & Physiotherapy, Theme Womens Hlth & Allied Hlth Profess, Stockholm, Sweden..
    ASSIST: a reablement program for older adults in Sweden - a feasibility study2022In: BMC Geriatrics, E-ISSN 1471-2318, Vol. 22, no 1, article id 618Article in journal (Refereed)
    Abstract [en]

    Background Western countries emphasise the provision of assistive home care by implementing reablement services. Reablement services are offered to a limited degree in Sweden, and systematic research regarding outcomes and how reablement can be tailored to maximize benefits for older adults has been lacking. This study aimed to evaluate the feasibility of a novel reablement program (ASSIST 1.0) regarding study design and outcome measures, as well as fidelity, adherence, and acceptability of the program in a Swedish context. Method A non-randomised, quasi-experimental, mixed-method, pre/post-test design was applied with an intervention group receiving ASSIST 1.0 (n = 7) and a control group receiving regular home care (n = 10). ASSIST 1.0 was developed to empower older adults to increase their perceived performance and satisfaction of performing activities in everyday life as well as increase their perceived health, self-efficacy, and well-being. ASSIST 1.0 was founded on the concept of reablement and included three components: i) goal setting with The Canadian Occupational Performance Measure (COPM), ii) provided support to home care staff to enhance their provision of reablement, and iii) explored the incorporation and use of an information- and communication technology (ICT) to facilitate information transfer. Results Using COPM for goal setting with older adults and providing support to the staff via workshops were valuable components in the delivery of ASSIST 1.0. The ICT product encountered several challenges and could not be evaluated. COPM and EQ-5D were deemed the most important instruments. Organisational and political barriers affected the feasibility. Although, the fidelity and adherence were complied the staff perceived the program to be acceptable. Conclusion The ASSIST 1.0 program was feasible in regard of study design, delivering the intervention, and evaluating instruments that detected a change. A logical progression would be to conduct a full-scale trial. In addition, a usability study to evaluate the technological component is also recommended. With minor improvements, the ASSIST 1.0 program has the potential to contribute to the development of a home care organisation that could enhance older adults possibility to age in place at home.

  • 39.
    Aziz, Adeeba
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    En jämförelse av metoder och verktyg för datahantering och analys inom datalager2024Independent thesis Basic level (university diploma), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    This bachelor’s thesis presents a comparative analysis of methods and tools for data management and analysis within data warehouses. With the rapidly increasing volume of data and the development of cloud technologies, companies face the challenge of navigating various methods to choose the most suitable one for their specific data management and analysis needs. The report highlights the One Big Table (OBT) method and the Data Build Tool (dbt), examining their advantages and disadvantages in data warehouse environments. To gain a deeper understanding of their functionality and efficiency, they are compared in different use cases through performance tests on latency and concurrency using the Hyperfine tool. OBT is implemented using Google BigQuery as well as Google Cloud SQL for PostgreSQL, where latency and concurrency for analytical purposes are evaluated using Python scripts with SQL queries and dbt models. The scripts and dbt models are run against BigQuery and PostgreSQL, both implementing OBT. The results show that the SQL scripts exhibited lower latency than the dbt models when executed against both BigQuery and PostgreSQL. Another finding is that the latency for SQL scripts was lower when run against PostgreSQL compared to BigQuery, while dbt models showed higher latency when run against PostgreSQL compared to BigQuery. The SQL scripts also performed better than the dbt models in concurrent executions in both BigQuery and PostgreSQL.

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  • 40.
    Baalsrud Hauge, Jannicke
    et al.
    KTH, School of Industrial Engineering and Management (ITM), Sustainable production development, Avancerad underhållsteknik och produktionslogistik.
    Soebke, Heinrich
    Bauhaus Univ Weimar, Goethepl 7-8, D-99423 Weimar, Germany..
    Broeker, Thomas
    Nuremberg Inst Technol, Nurnberg, Germany..
    Lim, Theodore
    Heriot Watt Univ, Edinburgh, Midlothian, Scotland..
    Luccini, Angelo Marco
    Succubus Interact, Nantes, France..
    Kornevs, Maksims
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Meijer, Sebastiaan
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Current Competencies of Game Facilitators and Their Potential Optimization in Higher Education: Multimethod Study2021In: JMIR Serious Games, E-ISSN 2291-9279, Vol. 9, no 2, article id e25481Article in journal (Refereed)
    Abstract [en]

    Background: Serious games can be a powerful learning tool in higher education. However, the literature indicates that the learning outcome in a serious game depends on the facilitators' competencies. Although professional facilitators in commercial game-based training have undergone specific instruction, facilitators in higher education cannot rely on such formal instruction, as game facilitation is only an occasional part of their teaching activities. Objective: This study aimed to address the actual competencies of occasional game facilitators and their perceived competency deficits. Methods: Having many years of experience as professional and occasional facilitators, we (n=7) defined requirements for the occasional game facilitator using individual reflection and focus discussion. Based on these results, guided interviews were conducted with additional occasional game facilitators (n=4) to check and extend the requirements. Finally, a group of occasional game facilitators (n=30) answered an online questionnaire based on the results of the requirement analysis and existing competency models. Results: Our review produced the following questions: Which competencies are needed by facilitators and what are their training needs? What do current training courses for occasional game facilitators in higher education look like? How do the competencies of occasional game facilitators differ from other competencies required in higher education? The key findings of our analysis are that a mix of managerial and technical competencies is required for facilitating serious games in higher educational contexts. Further, there is a limited or no general competence model for game facilitators, and casual game facilitators rarely undergo any specific, formal training. Conclusions: The results identified the competencies that game facilitators require and a demand for specific formal training. Thus, the study contributes to the further development of a competency model for game facilitators and enhances the efficiency of serious games.

  • 41.
    Balachandran, Sarugan
    et al.
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Perez Legrand, Diego
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Evaluating machine learning models for time series forecasting in smart buildings2023Independent thesis Basic level (university diploma), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Temperature regulation in buildings can be tricky and expensive. A common problem when heating buildings is that an unnecessary amount of energy is supplied. This waste of energy is often caused by a faulty regulation system. This thesis presents a machine learning ap- proach, using time series data, to predict the energy supply needed to keep the inside tem- perature at around 21 degrees Celsius. The machine learning models LSTM, Ensemble LSTM, AT-LSTM, ARIMA, and XGBoost were used for this project. The validation showed that the ensemble LSTM model gave the most accurate predictions with the Mean Absolute Error of 22486.79 (Wh) and Symmetric Mean Absolute Percentage Error of 5.41 % and was the model used for comparison with the current system. From the performance of the different models, the conclusion is that machine learning can be a useful tool to pre- dict the energy supply. But on the other hand, there exist other complex factors that need to be given more attention to, to evaluate the model in a better way.

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  • 42.
    Balogh, Dora B.
    et al.
    Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary.
    Hudelist, Gernot
    Department of Gynecology, Center for Endometriosis, Hospital St. John of God, Vienna, Austria; Rudolfinerhaus Private Clinic and Campus, Vienna, Austria.
    Bļizņuks, Dmitrijs
    Department of Computer Control and Computer Networks, Riga Technical University, Riga, Latvia.
    Raghothama, Jayanth
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Becker, Christian M.
    Oxford Endometriosis CaRe Centre, Nuffield Department of Women’s and Reproductive Health, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
    Horace, Roman
    Franco-European Multidisciplinary Endometriosis Institute (IFEMEndo), Clinique Tivoli-Ducos, Bordeaux, France, Clinique Tivoli-Ducos.
    Krentel, Harald
    Department of Obstetrics, Gynecology, Gynecologic Oncology and Senology, Bethesda Hospital Duisburg, Duisburg, Germany.
    Horne, Andrew W.
    Centre for Reproductive Health, University of Edinburgh, Institute of Inflammation and Repair, Edinburgh, United Kingdom.
    Bourdel, Nicolas
    Department of Surgical Gynecology, University of Clermont Auvergne, Clermont-Ferrand, France.
    Marki, Gabriella
    MedEnd Institute, Budapest, Hungary.
    Tomassetti, Carla
    Leuven University Endometriosis Center of Expertise, Leuven University Fertility Center, Department of Obstetrics and Gynecology, UZ Gasthuisberg, Leuven, Belgium.
    Kirk, Ulrik Bak
    Department of Public Health, Aarhus University, Aarhus, Denmark; Research Unit for General Practice, Aarhus, Denmark.
    Acs, Nandor
    Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary.
    Bokor, Attila
    Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary.
    FEMaLe: The use of machine learning for early diagnosis of endometriosis based on patient self-reported data—Study protocol of a multicenter trial2024In: PLOS ONE, E-ISSN 1932-6203, Vol. 19, no 5 May, article id e0300186Article in journal (Refereed)
    Abstract [en]

    Introduction Endometriosis is a chronic disease that affects up to 190 million women and those assigned female at birth and remains unresolved mainly in terms of etiology and optimal therapy. It is defined by the presence of endometrium-like tissue outside the uterine cavity and is commonly associated with chronic pelvic pain, infertility, and decreased quality of life. Despite the availability of various screening methods (e.g., biomarkers, genomic analysis, imaging techniques) intended to replace the need for invasive surgery, the time to diagnosis remains in the range of 4 to 11 years. Aims This study aims to create a large prospective data bank using the Lucy mobile health application (Lucy app) and analyze patient profiles and structured clinical data. In addition, we will investigate the association of removed or restricted dietary components with quality of life, pain, and central pain sensitization. Methods A baseline and a longitudinal questionnaire in the Lucy app collects real-world, self-reported information on symptoms of endometriosis, socio-demographics, mental and physical health, economic factors, nutritional, and other lifestyle factors. 5,000 women with confirmed endometriosis and 5,000 women without diagnosed endometriosis in a control group will be enrolled and followed up for one year. With this information, any connections between recorded symptoms and endometriosis will be analyzed using machine learning. Conclusions We aim to develop a phenotypic description of women with endometriosis by linking the collected data with existing registry-based information on endometriosis diagnosis, healthcare utilization, and big data approach. This may help to achieve earlier detection of endometriosis with pelvic pain and significantly reduce the current diagnostic delay. Additionally, we may identify dietary components that worsen the quality of life and pain in women with endometriosis, upon which we can create real-world data-based nutritional recommendations.

  • 43.
    Barsum, Rita
    et al.
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Racho, Gizelle
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Developing an IoT-based medicine dosage system2022Independent thesis Basic level (university diploma), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Some individuals and older adults have trouble remembering when to take their medication. A medication dispenser machine is one suggested solution to this problem. The purpose of this thesis is to design a prototype of a wireless machine for storing and releasing patients’ medication dosages at a certain time. The user can insert the medication schedule through a platform connected to the machine via wireless technology. In order to achieve the purpose, a literature study was conducted to gather and analyze information about wireless communication technologies to determine the most appropriate wireless technology for the thesis end device. The Arduino MKR NB 1500 is the core component of the prototype of the wireless system. Several types of tests were conducted on the system to evaluate its performance, as well as to determine NB-IoT coverage in real-world scenarios. The NB-IoT technology was proven to be the more suitable technology for the wireless pill dispensing machine and for other IoT applications. Moreover, the system performed satisfactorily in solving the defined problem. Despite this, the system could be improved in terms of design, mechanisms, and hygiene system of medicines.

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  • 44.
    Bashar, Nour
    et al.
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Alsaid Suliman, MRami
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Vitiligo image classification using pre-trained Convolutional Neural Network Architectures, and its economic impact on health care2022Independent thesis Basic level (university diploma), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Vitiligo is a skin disease where the pigment cells that produce melanin die or stop functioning, which causes white patches to appear on the body. Although vitiligo is not considered a serious disease, there is a risk that something is wrong with a person's immune system. In recent years, the use of medical image processing techniques has grown, and research continues to develop new techniques for analysing and processing medical images. In many medical image classification tasks, deep convolutional neural network technology has proven its effectiveness, which means that it may also perform well in vitiligo classification. Our study uses four deep convolutional neural networks in order to classify images of vitiligo and normal skin. The architectures selected are VGG-19, ResNeXt101, InceptionResNetV2 and Inception V3. ROC and AUC metrics are used to assess each model's performance. In addition, the authors investigate the economic benefits that this technology may provide to the healthcare system and patients. To train and evaluate the CNN models, the authors used a dataset that contains 1341 images in total. Because the dataset is limited, 5-fold cross validation is also employed to improve the model's prediction. The results demonstrate that InceptionV3 achieves the best performance in the classification of vitiligo, with an AUC value of 0.9111, and InceptionResNetV2 has the lowest AUC value of 0.8560.

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    Vitiligo image classification
  • 45. Bekius, F.
    et al.
    Meijer, Sebastiaan
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Thomassen, H.
    A Real Case Application of Game Theoretical Concepts in a Complex Decision-Making Process: Case Study ERTMS2022In: Group Decision and Negotiation, ISSN 0926-2644, E-ISSN 1572-9907, Vol. 31, no 1, p. 153-185Article in journal (Refereed)
    Abstract [en]

    Engineering systems are complex, amongst others due to the interdependencies between actor and technical aspects. This complexity has consequences for the way of designing such systems and, in particular, for the decision-making process. Recognizing the impossibility of having an optimal system design in such complex systems, this article explores how a game theoretical characterization of a decision-making process assists in the organization and design of the process itself. In contrast to a game theoretical analysis, which results in optimal outcomes, the characterization is fed back to the designers of the decision-making process during the course of the process. The study analyses how the game concept characterization was used, i.e., which strategies were defined during the game theory interventions, and what the consequences of these strategies were for the design of the decision-making process. The design of a new safety system ERTMS for the Dutch railway sector is the context in which the study was performed. The contribution is a successful approach to complex decision-making in multi-actor systems by identification of multiple game concepts over time, with periodic feedback into the designing system, and not the actual decision-making itself. In short, it supported adapting to an actor focus on the process, it affected the role and responsibilities of the program management, it contributed to (de)coupling of issues, and it influenced the capability of creating awareness amongst actors of the urgency of the decision window. The paper ends with reflections on the experience of intervening in a decision-making process with game theoretical concepts.

  • 46.
    Bekius, Femke
    et al.
    Radboud University NijmegenNijmegenThe Netherlands.
    Meijer, Sebastiaan
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics. Delft University of TechnologyDelftThe Netherlands.
    Selecting the Right Game Concept for Social Simulation of Real-World Systems2020In: Springer Proceedings in Complexity, Springer , 2020, p. 71-79Conference paper (Refereed)
    Abstract [en]

    Game theoretical models can be used for social simulation of real-world systems. These models describe the interaction between actors who have to make a decision. Before application of those models, the game concept that describes the situation at hand needs to be selected. Selecting the right game concept is crucial when choosing a model to simulate the process, but not trivial. In this paper we present a taxonomy of game concepts to select a set of suitable models.

  • 47.
    Belitz-Hellwich, Wiebke
    et al.
    KTH, School of Architecture and the Built Environment (ABE), Civil and Architectural Engineering, Structural Engineering and Bridges.
    Abourraja, Mohamed Nezar
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Gram, Annika
    KTH, School of Architecture and the Built Environment (ABE), Civil and Architectural Engineering, Building Technology and Design.
    Kringos, Nicole
    KTH, School of Architecture and the Built Environment (ABE), Civil and Architectural Engineering, Structural Engineering and Bridges.
    Cross-Domain Compatibility in a Port Environment: Spatio-Temporal Interoperability and its PerformanceManuscript (preprint) (Other academic)
  • 48.
    Bentersten, William
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Upptäcka kritiska ändringar i JSON-meddelanden i webb-API:er2019Independent thesis Advanced level (professional degree), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    One way of developing web applications is in two parts, where one part is an API and the other part is the client. This report focuses on JSON APIs and on finding a solution for identifying breaking changes in JSON messages before they affect their intended client in undesirable ways.

    A case study has been carried out at a company that develops their web applications in two parts. The result is a web application (a tool) that solves the problem by recording API requests that are then replayed against different versions of the API. Version tagged responses are collected and compared against each other by different aspects.

    The web application (the tool) succeeds in identifying breaking changes in JSON messages. This is verified using a test API, which in turn verifies the thesis’ hypothesis.

    To test an API, whose underlying application is stateful, that application is expected to be reset to a standardized state before each use of the tool. This is a limitation.

    There is potential for future development in getting the tool work against authenticated APIs.

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  • 49.
    Berezkin, Nikita
    et al.
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Heidari, Ahmed
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Berika receptdata med innehållshanteringssystem2019Independent thesis Basic level (university diploma), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The problem today is that people do not eat climate-smart food; this results in that the food will not suffice, and what we eat may harm the greenhouse effect. The problem is that people do not have the time or knowledge to cook climate-smart food. A solution is to use a Content Management System (CMS). A Content Management System processes selected type of data in a specific way which is then stored. This report will address the basics and the making of a CMS in a recommendation system for a user. The system will entail a more climate-smart food alternative to achieve the individual's personal needs. The result was that with the help of data from various sources, an ingredient of a recipe could add additional information such as nutritional value, allergies, and whether it is vegetarian. Tests such as performance tests on the execution time for the CMS, parsing accuracy, and matching product accuracy, a better result was achieved. Most of the ingredients in the recipe became enriched, which leads to more climate-smart food alternatives, which are better for the environment. The accuracy is the matching of ingredients in the recipe to the names of products in the business. The next step was to enrich the recipes using enriched ingredients.

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    Enriching Recipe Data using Content Management System
  • 50.
    Berg, Alfred
    et al.
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Lamberg, Norton
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Health Informatics and Logistics.
    Automatic fingerprinting of websites2020Independent thesis Basic level (university diploma), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Abstract

    Fingerprinting a website is the process of identifying what technologies a websiteuses, such as their used web applications and JavaScript frameworks. Currentfingerprinting methods use manually created fingerprints for each technology itlooks for. These fingerprints consist of multiple text strings that are matchedagainst an HTTP response from a website. Creating these fingerprints for eachtechnology can be time-consuming, which limits what technologies fingerprints canbe built for. This thesis presents a potential solution by utilizing unsupervisedmachine learning techniques to cluster websites by their used web application andJavaScript frameworks, without requiring manually created fingerprints. Oursolution uses multiple bag-of-words models combined with the dimensionalityreduction technique t-SNE and clustering algorithm OPTICS. Results show thatsome technologies, for example, Drupal, achieve a precision of 0.731 and recall of0.485 without any training data. These results lead to the conclusion that theproposed solution could plausibly be used to cluster websites by their webapplication and JavaScript frameworks in use. However, further work is needed toincrease the precision and recall of the results.

    Keywords

    Clustering, fingerprinting, OPTICS, t-SNE, headless browser, bag-of-words,unsupervised machine learning

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    fulltext
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