Digitala Vetenskapliga Arkivet

Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
AVD is an effective chemotherapy backbone in first-line treatment of older patients with classical Hodgkin lymphoma
Uppsala Univ, Sweden; Akad Univ Hosp, Sweden.
Baerum Hosp, Norway; Univ Oslo, Norway; Oslo Univ Hosp, Norway.
Uppsala Univ, Sweden; Akad Univ Hosp, Sweden.
Aarhus Univ Hosp, Denmark.
Show others and affiliations
2026 (English)In: Blood Advances, ISSN 2473-9529, E-ISSN 2473-9537, Vol. 10, no 14, p. 4889-4897Article in journal (Refereed) Published
Abstract [en]

No universal gold standard chemotherapy exists for the treatment of older (>= 60 years) patients with classical Hodgkin lymphoma (cHL). To evaluate the current curative treatment strategies used in the Nordic countries, we collected data from patients diagnosed in Sweden, Denmark and Norway during the years 2000 to 2021. We included 1569 patients: 704 (45%) Swedish, 671 (43%) Danish, and 194 (12%) Norwegian. Of these, 671 (43%) received doxorubicin, bleomycin, vinblastine, dacarbazine (ABVD), 123 (8%) received doxorubicin, vinblastine, and dacarbazine (AVD), 465 (31%) received cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP), and 212 (13%) received other chemotherapy (single agent or combination). Eighty-two (5%) patients lacked information on first-line regimen. In multivariable analyses of overall survival (OS), treatment with AVD was associated with improved survival compared to ABVD, whereas there was a trend toward inferior survival among patients receiving CHOP or other regimens. For progression-free survival (PFS), multivariable analysis likewise demonstrated significantly improved outcome with AVD relative to ABVD, whereas outcomes for the CHOP group were comparable to ABVD. Outcome for patients receiving other regimens tended to be poorer. Collectively, outcome for AVD with respect to both OS and PFS was at least equal to ABVD and often superior to CHOP. By omitting bleomycin, treatment-related toxicity is known to be reduced in AVD compared to ABVD. Based on our findings, AVD is a preferable chemotherapy option in older patients with cHL and should rightly be considered as backbone in treatment with novel drugs.

Place, publisher, year, edition, pages
ELSEVIER , 2026. Vol. 10, no 14, p. 4889-4897
National Category
Pharmaceutical and Medical Biotechnology
Identifiers
URN: urn:nbn:se:liu:diva-226571DOI: 10.1182/bloodadvances.2025018954ISI: 001828009500001PubMedID: 41921203Scopus ID: 2-s2.0-105044327171OAI: oai:DiVA.org:liu-226571DiVA, id: diva2:2092199
Note

Funding Agencies|Cancerfonden, Svenska Saellskapet foer Medicinsk Forskning, Stiftelsen Onkologiska Klinikens i Uppsala Cancerforskningsfond, and Lion's Cancerforskningsfond vid Akademiska sjukhuset [23 30018]

Available from: 2026-08-14 Created: 2026-08-14 Last updated: 2026-08-14

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedScopus

Search in DiVA

By author/editor
Lagerlöf, Ingemar
By organisation
Department of Biomedical and Clinical SciencesFaculty of Medicine and Health SciencesDepartment of Haematology
In the same journal
Blood Advances
Pharmaceutical and Medical Biotechnology

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 1 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf