This article introduces the MOSI (Medical Yoga Standardized Intervention) theoretical framework, developed to address challenges in the systematic implementation of yoga into healthcare, including intervention heterogeneity and the absence of clinically operational theoretical structures. Informed by long-term clinical application, structured feedback from healthcare professionals, and insights derived from research studies and implementation experience, including patient perspectives - an iterative conceptual analysis and interdisciplinary collaboration guided the development of this framework. It establishes a structured taxonomic derivation and theoretical architecture that operationalizes traditional yoga principles into a clinically applicable structure of a four-layer model comprising four interconnected layers - Self-Care Aspects, Intentional Layer, Practice Layer, and Awareness Layer. The MOSI theoretical framework addresses methodological needs in standardization and implementation, providing a unified language and a structured theoretical foundation to support standardized, reproducible, and clinically applicable yoga intervention design and implementation.