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New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475000 Individuals
Washington Univ, Sch Med, Div Stat Genom, Dept Genet, St Louis, MO 63108 USA.;Washington Univ, Sch Med, Ctr Genome Sci & Syst Biol, St Louis, MO 63108 USA..
Univ Liverpool, Dept Biostatist, Liverpool, Merseyside, England..
William Harvey Res Inst, Dept Clin Pharmacol, London, England.;Queen Mary Univ London, London Sch Med & Dent, London, England.;Queen Mary Univ London, Natl Inst Hlth Res, Baits Cardiovasc Biomed Res Unit, London, England..
MRC BHF Cardiovasc Epidemiol Ctr, Dept Publ Hlth & Primary Care, Cambridge, England..
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2017 (English)In: Circulation: Cardiovascular Genetics, ISSN 1942-325X, E-ISSN 1942-3268, Vol. 10, no 5, article id e001778Article in journal (Refereed) Published
Abstract [en]

Background - Genome-wide association studies have recently identified >400 loci that harbor DNA sequence variants that influence blood pressure (BP). Our earlier studies identified and validated 56 single nucleotide variants (SNVs) associated with BP from meta-analyses of exome chip genotype data. An additional 100 variants yielded suggestive evidence of association.

Methods and Results - Here, we augment the sample with 140886 European individuals from the UK Biobank, in whom 77 of the 100 suggestive SNVs were available for association analysis with systolic BP or diastolic BP or pulse pressure. We performed 2 meta-analyses, one in individuals of European, South Asian, African, and Hispanic descent (pan-ancestry, approximate to 475000), and the other in the subset of individuals of European descent (approximate to 423000). Twenty-one SNVs were genome-wide significant (P<5x10(-8) ) for BP, of which 4 are new BP loci: rs9678851 (missense, SLC4A1AP), rs7437940 (AFAP1), rs13303 (missense, STAB1), and rs1055144 (7p15.2). In addition, we identified a potentially independent novel BP-associated SNV, rs3416322 (missense, SYNPO2L) at a known locus, uncorrelated with the previously reported SNVs. Two SNVs are associated with expression levels of nearby genes, and SNVs at 3 loci are associated with other traits. One SNV with a minor allele frequency <0.01, (rs3025380 at DBH) was genome-wide significant.

Conclusions - We report 4 novel loci associated with BP regulation, and 1 independent variant at an established BP locus. This analysis highlights several candidate genes with variation that alter protein function or gene expression for potential follow-up.
Place, publisher, year, edition, pages
LIPPINCOTT WILLIAMS & WILKINS , 2017. Vol. 10, no 5, article id e001778
Keywords [en]
blood pressure, exome, genetics, genotype, sample size
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-347269DOI: 10.1161/CIRCGENETICS.117.001778ISI: 000424292400015OAI: oai:DiVA.org:uu-347269DiVA, id: diva2:1194494
Available from: 2018-04-03 Created: 2018-04-03 Last updated: 2018-04-03Bibliographically approved

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