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Brain Sex in Transgender Women Is Shifted towards Gender Identity
Univ Auckland, Sch Psychol, Auckland 1010, New Zealand..
Jena Univ Hosp, Dept Psychiat, D-07747 Jena, Germany.;Jena Univ Hosp, Dept Neurol, D-07747 Jena, Germany..
Univ Missouri, Coll Educ & Human Dev, Columbia, MO 65211 USA..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. Univ Auckland, Sch Psychol, Auckland 1010, New Zealand.;Univ Southern Calif, Sch Med, Lab Neuro Imaging, Los Angeles, CA 90033 USA..
2022 (English)In: Journal of Clinical Medicine, E-ISSN 2077-0383, Vol. 11, no 6, article id 1582Article in journal (Refereed) Published
Abstract [en]

Transgender people report discomfort with their birth sex and a strong identification with the opposite sex. The current study was designed to shed further light on the question of whether the brains of transgender people resemble their birth sex or their gender identity. For this purpose, we analyzed a sample of 24 cisgender men, 24 cisgender women, and 24 transgender women before gender-affirming hormone therapy. We employed a recently developed multivariate classifier that yields a continuous probabilistic (rather than a binary) estimate for brains to be male or female. The brains of transgender women ranged between cisgender men and cisgender women (albeit still closer to cisgender men), and the differences to both cisgender men and to cisgender women were significant (p = 0.016 and p < 0.001, respectively). These findings add support to the notion that the underlying brain anatomy in transgender people is shifted away from their biological sex towards their gender identity.

Place, publisher, year, edition, pages
MDPI AG , 2022. Vol. 11, no 6, article id 1582
Keywords [en]
brain, gender identity, machine learning, MRI, sex classifier, transgender
National Category
Gender Studies
Identifiers
URN: urn:nbn:se:uu:diva-472937DOI: 10.3390/jcm11061582ISI: 000775146600001PubMedID: 35329908OAI: oai:DiVA.org:uu-472937DiVA, id: diva2:1653468
Note

De två första författarna delar förstaförfattarskapet.

Available from: 2022-04-22 Created: 2022-04-22 Last updated: 2022-04-22Bibliographically approved

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