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Psilocybin's effects on the brain and implications for depression treatment
Luleå University of Technology, Department of Business Administration, Technology and Social Sciences.
2020 (English)Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
Abstract [en]

Mental illnesses, especially depression, are a global problem that require new treatment options to those whose symptoms are resistant to the current ones. Psilocybin, which is a naturally occurring drug in mushrooms, has become a potential candidate. It affects the brain by deactivating certain areas, causing not only changes in perception and consciousness but antidepressive responses as well, thereby improving well-being. Previous studies have looked at psilocybin and how it affects the brain, and also shown that short trials with psilocybin can cause long-lasting improvement. Here, I conducted an analysis including nine experimental articles that had studied psilocybin’s effects on depressive symptoms. Results confirm that psilocybin does decrease depressive symptoms, even long-lastingly, while only transient mild side effects being fairly common. Some conclusions could also be drawn of which types of patients will benefit of psilocybin treatment most likely. Future research with bigger sample sizes is needed, as well as more focus on identifying the ideal settings and patients of psilocybin-assisted therapy. 

Abstract [sv]

Mental ohälsa och särskilt depression är globala problem. Nya behandlingsalternativ behövs för de som inte får hjälp av nuvarande behandlingar. Psilocybin är ett ämne som finns i så kallade magiska svampar och har blivit en potentiell kandidat. Psilocybin påverkar hjärnan genom att inaktivera vissa delar, vilket leder till förändringar i perception, medvetandet och antidepressiva responser bland annat. Tidigare forskning har fokuserat på hur psilocybin påverkar hjärnan samt visat att även kortvarig behandling med psilocybin kan framkalla en långvarig förbättring av hur man mår. Denna analys inkluderar nio experiementella studier om psilocybins effekter på depressiva symtom. Resultatet visar att psilocybin minskar depressiva symptom, även långvarigt. Endast kortvariga milda bieffekter var rapporterade. Framtida forskning bör ha ett större antal av deltagare samt fokusera på att identifiera idealgruppen för denna typ av behandling.

Place, publisher, year, edition, pages
2020. , p. 20
Keywords [en]
psilocybin, depression, psychedelic-assisted therapy
Keywords [fi]
psilosybiini, masennus, psykedeeliavusteinen terapia
Keywords [sv]
psilocybin, depression, psykedelisk terapi
National Category
Psychology
Identifiers
URN: urn:nbn:se:ltu:diva-79481OAI: oai:DiVA.org:ltu-79481DiVA, id: diva2:1439874
Educational program
Psychology, bachelor's level
Supervisors
Examiners
Available from: 2020-06-17 Created: 2020-06-12 Last updated: 2025-10-22Bibliographically approved

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CiteExportLink to record
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Citation style
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