Within the Swedish National Monitoring Programme for Contaminants in marine biota, a selection of the wide array of contaminants that can be found in the environment is analysed. Analysing the samples for all possible contaminants would hardly be feasible, however, screening for different substance groups is a way to investigate if and where new substances arise and may pose a threat to wildlife and humans. In this report, data from a spatial screening study is presented, which aimed to densify the ongoing Swedish National Monitoring Programme for Contaminants in marine biota with regard to pharmaceuticals, phthalates and polycyclic aromatic hydrocarbons (PAHs). The study includes 16 sampling sites along the Swedish coast, from where two different species of bivalves, Limecola balthica and Mytilus edulis, were collected. All applied sampling material in this screening study originates from the Swedish Environmental Specimen Bank of the Swedish Museum of Natural History. The screening included a total of 100 pharmaceuticals, out of which 17 were detected and quantified in at least one sampling site. Risperidone was the pharmaceutical detected at most sites (10 of 13). The only detected phthalate was di(2-ethylhexyl) phthalate (DEHP), which was found in the samples from 3 of 13 sampling sites. Among the PAHs, Benzo(a)pyrene was the substance quantified at most sites (14 out of 16). No geographical patterns could be identified for the detected contaminants, besides for the PAHs. However, this pattern could also be due to a difference in species rather than due to location. PAHs could be detected in the Bothnian Sea and the Sea of Åland, where to date no mussel sampling sites exist within the Swedish National Monitoring Programme for Contaminants in marine biota. The Baltic clam might be a good additional monitoring species besides the Blue mussel, due to their difference in feeding strategy and the potential higher PAH uptake from contaminated sediments rather than the water phase.