Alcohol impairs learning and timing of conditioned eyeblink responsesVisa övriga samt affilieringar
2025 (Engelska)Ingår i: Brain Research, ISSN 0006-8993, E-ISSN 1872-6240, Vol. 1854, artikel-id 149545Artikel i tidskrift (Refereegranskat) Published
Abstract [en]
Alcohol impairs motor performance, but it remains unclear precisely why this is the case. Here, we examine the effects of alcohol intoxication on conditioned eyeblink responses, a form of classical conditioning dependent on the cerebellum. In experiment 1, the conditioned responses of 18 students before and after alcohol consumption up to 1 ‰ were compared against the performance of 26 non-drinking controls. In experiment 2, 17 students were tested repeatedly at increasing blood alcohol levels up to 1 ‰. The results reveal a gradual decrease in both the percentage and timing of conditioned responses following alcohol consumption, with pronounced impairments emerging at blood alcohol content levels exceeding 0.5 ‰. These findings are consistent with the idea that the motor deficits associated with alcohol consumption are linked to effects on the cerebellum.
Ort, förlag, år, upplaga, sidor
Elsevier, 2025. Vol. 1854, artikel-id 149545
Nyckelord [en]
Alcohol, Cerebellum, Eyeblink Conditioning, Motor Ability, Motor Learning, Pharmacology, Timing
Nationell ämneskategori
Neurovetenskaper
Identifikatorer
URN: urn:nbn:se:umu:diva-236456DOI: 10.1016/j.brainres.2025.149545ISI: 001441137100001PubMedID: 40024359Scopus ID: 2-s2.0-85219513305OAI: oai:DiVA.org:umu-236456DiVA, id: diva2:1945995
Forskningsfinansiär
Vetenskapsrådet, 2020-01468Crafoordska stiftelsen, 20180704Crafoordska stiftelsen, 20200729Crafoordska stiftelsen, 20220796Crafoordska stiftelsen, 20230655Hjärnfonden, FO2024-0361Kungliga Fysiografiska Sällskapet i Lund, 2022-04-25Gyllenstiernska Krapperupsstiftelsen, KR2021-0040Gyllenstiernska Krapperupsstiftelsen, KR2024-0102Sten K Johnsons Stiftelse, 20230153Sten K Johnsons Stiftelse, 20240482Petrus och Augusta Hedlunds Stiftelse, M-2024-2498Magnus Bergvalls Stiftelse, 2020-03788Magnus Bergvalls Stiftelse, 2023-861Thorsten och Elsa Segerfalks Stiftelse, 2019-2246Åke Wibergs Stiftelse, M18-0070Åke Wibergs Stiftelse, M19-0375Åke Wibergs Stiftelse, M20-0008Fredrik och Ingrid Thurings Stiftelse, 2018-00366Fredrik och Ingrid Thurings Stiftelse, 2019-005162025-03-202025-03-202025-03-20Bibliografiskt granskad