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  • von Bahr, Joar
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. Karolinska Inst, Dept Global Publ Hlth, Stockholm, Sweden.;Univ Helsinki, Inst Mol Med Finland FIMM, Helsinki, Finland..
    Suutala, Antti
    Univ Helsinki, Inst Mol Med Finland FIMM, Helsinki, Finland..
    Kucukel, Hakan
    Univ Helsinki, Inst Mol Med Finland FIMM, Helsinki, Finland..
    Kaingu, Harrison
    Kinondo Kwetu Hosp, Kinondo, Kwale County, Kenya..
    Kinyua, Felix
    Kinondo Kwetu Hosp, Kinondo, Kwale County, Kenya..
    Muinde, Martin
    Kinondo Kwetu Hosp, Kinondo, Kwale County, Kenya..
    Osundwa, Kevan
    Kinondo Kwetu Hosp, Kinondo, Kwale County, Kenya..
    Ronald, Wigina
    Tech Univ Mombasa, Dept Med Sci, Mombasa, Kenya..
    Muinde, Jackson
    Minist Hlth, Mombasa, Kwale County, Kenya..
    Ngasala, Billy
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, International Child Health and Nutrition. Muhimbili Univ Hlth & Allied Sci, Dept Parasitol & Med Entomol, Dar Es Salaam, Tanzania..
    Lundin, Mikael
    Univ Helsinki, Inst Mol Med Finland FIMM, Helsinki, Finland..
    Mårtensson, Andreas
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, International Child Health and Nutrition. Uppsala Univ Hosp, Dept Infect Dis, Uppsala, Sweden..
    Linder, Nina
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, International Child Health and Nutrition. Univ Helsinki, Inst Mol Med Finland FIMM, Helsinki, Finland..
    Lundin, Johan
    Karolinska Inst, Dept Global Publ Hlth, Stockholm, Sweden.;Univ Helsinki, Inst Mol Med Finland FIMM, Helsinki, Finland..
    AI-supported versus manual microscopy of Kato-Katz smears for diagnosis of soil-transmitted helminth infections in a primary healthcare setting2025In: Scientific Reports, E-ISSN 2045-2322, Vol. 15, no 1, article id 20332Article in journal (Refereed)
    Abstract [en]

    Soil-transmitted helminths primarily comprise Ascaris lumbricoides, Trichuris trichiura, and hookworms, infecting more than 600 million people globally, particularly in underserved communities. Manual microscopy of Kato-Katz thick smears is a widely used diagnostic method in monitoring and control programs, but is time-consuming, requires on-site experts and has low sensitivity, especially for light intensity infections. In this study, portable whole-slide scanners and deep learning-based artificial intelligence (AI) were deployed in a primary healthcare setting in Kenya. Stool samples (n = 965) were collected from school children and Kato-Katz thick smears were digitized for AI-based detection. Light-intensity infections accounted for 96.7% of cases. Three diagnostic methods - manual microscopy, autonomous AI and human expert-verified AI - were compared to a composite reference standard, which combined expert-verified helminth eggs in physical and digital smears. Sensitivity for A. lumbricoides, T. trichiura and hookworms was 50.0%, 31.2%, and 77.8% for manual microscopy; 50.0%, 84.4%, and 87.4% for the autonomous AI; and 100%, 93.8%, and 92.2% for expert-verified AI in smears suitable for analysis (n = 704). Specificity exceeded 97% across all methods. The expert-verified AI had higher sensitivity than the other methods while maintaining high specificity for the detection of soil-transmitted helminths in Kato-Katz thick smears, especially in light-intensity infections.

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  • Arhrib, A.
    et al.
    Abdelmalek Essaadi Univ, Fac Sci & Tech, Boite Postale 2117, Tetouan, Tanger, Morocco.;Natl Tsing Hua Univ, Dept Phys, Hsinchu 300, Taiwan.;Natl Tsing Hua Univ, Ctr Theory & Computat, Hsinchu 300, Taiwan..
    Moretti, Stefano
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics. Univ Southampton, Sch Phys & Astron, Southampton SO17 1BJ, England..
    Semlali, S.
    Univ Southampton, Sch Phys & Astron, Southampton SO17 1BJ, England.;Rutherford Appleton Lab, Particle Phys Dept, Didcot OX11 0QX, Oxon, England..
    Shepherd-Themistocleous, C. H.
    Rutherford Appleton Lab, Particle Phys Dept, Didcot OX11 0QX, Oxon, England..
    Wang, Y.
    Inner Mongolia Normal Univ, Coll Phys & Elect Informat, Hohhot 010022, Peoples R China.;Inner Mongolia Normal Univ, Inner Mongolia Key Lab Phys & Chem Funct Mat, Hohhot 010022, Peoples R China..
    Yan, Q. S.
    Chinese Acad Sci, Ctr Future High Energy Phys, Beijing 100049, Peoples R China.;Univ Chinese Acad Sci, Sch Phys Sci, Beijing 100039, Peoples R China..
    Probing a 2HDM type-I light Higgs state via HSM → hh →†’ bb<overline>γγ at the LHC2025In: Physical Review D: covering particles, fields, gravitation, and cosmology, ISSN 2470-0010, E-ISSN 2470-0029, Vol. 111, no 9, article id 095035Article in journal (Refereed)
    Abstract [en]

    We study the discovery potential for a light Higgs boson via gg → HSM-like → hh → bb<overline>γγ process at the Large Hadron Collider (LHC). Focusing on the 2-Higgs Doublet Model Type-I, which can accommodate light neutral Higgs states, of O(100) GeV or less in mass, while agreeing with theoretical and up-to-date experimental constraints, we explore the feasibility of a light CP-even Higgs state h via the largely unexplored final state bb<overline>γγ at Run-3 of the LHC. We further propose a few benchmark points for future searches.

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  • Fredriksson, Mio
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Health Services Research.
    Mattebo, Magdalena
    Mälardalen Univ, Sch Hlth Care & Social Welf, Div Caring Sci & Hlth Care Pedag, Box 883, S-72123 Västerås, Sweden..
    The struggle over caesarean section on maternal request: an ethical principles approach to Swedish media portrayal2025In: Reproductive Health, E-ISSN 1742-4755, Vol. 22, no 1, article id 118Article in journal (Refereed)
    Abstract [en]

    Background: Caesarean section on maternal request (CSMR) is a complex ethical issue. Sweden is an intriguing case for studying CSMR due to its restrictive policy that curtail women autonomous choice regarding the mode of birth, despite overall policy developments aiming to strengthen patients' rights, promote person-centred care, and adopt a more individualized approach. This study aims to understand how the tension surrounding CSMR is manifested in Swedish media. An ethical principles approach is used to investigate what image of CSMR is created and conveyed to the public and what main arguments are used for and against CSMR.

    Methods: This study covers news media and specialist press material in Sweden between March 2019 and March 2024. Searches were carried out in Retriever Research and resulted in 188 search hits. The content analysis had both an inductive and a deductive approach based on Beauchamp and Childress's four ethical principles: respect for autonomy, non-maleficence, beneficence, and justice.

    Results: The analysis reveals a struggle in Swedish media over how to approach CSMR, touching on all ethical principles. Regarding autonomy, the debate focuses on whether CSMR is a medical decision about non-indicated surgery or a private choice. In terms of non-maleficence-which is the health professionals' main concern-the media highlights conflicts over interpreting risks associated with caesarean section and vaginal birth. Beneficence involves a tension between portraying vaginal birth as healthy and normal versus caesarean section as a method to protect sexual and bodily function. As regards justice, CSMR is portrayed as a challenge to the fundamental needs-principle in the healthcare system.

    Conclusions: Ultimately, the ethical principles approach to analyzing the media portrayal of CSMR in Sweden highlights the need for decision guidelines and practices that are more open to a woman's own evaluation of different risks while also encouraging critical reflection on the underlying factors shaping treatment preferences for both women and healthcare professionals.

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  • Mackey, Allison
    et al.
    Karolinska Inst, Dept Clin Sci Intervent & Technol, Stockholm, Sweden..
    Löfkvist, Ulrika
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Social medicine/CHAP. Karolinska Inst, Dept Clin Sci Intervent & Technol, Stockholm, Sweden..
    Exploring hygiene practices, prenatal recommendations and parental attitudes towards congenital cytomegalovirus prevention and screening in Sweden2025In: BMJ Paediatrics Open, E-ISSN 2399-9772, Vol. 9, no 1, article id e003524Article in journal (Refereed)
    Abstract [en]

    Objective: The aims of the study were to explore the attitudes of parents of young children towards prevention and screening for congenital cytomegalovirus infection, and to map the practices and recommendations in prenatal care regarding the prevention of fetal infection.

    Methods: A survey was distributed across Sweden to parents of children under 2 years. Information about congenital cytomegalovirus infection was provided. Questions followed, pertaining to attitudes towards screening and prevention, hygiene behaviours during pregnancy, and recommendations from midwives.

    Results: 4405 parents completed the survey; 4263 were pregnant less than 2 years prior. Parents were positive towards screening, with 85% agreeing that screening should be offered. A predicted increase in stress was positively associated with positive attitudes towards screening. Attitudes towards prevention were positive (90%). Most did not regularly perform hygiene measures to prevent cytomegalovirus infection during pregnancy, though behaviours preventing other infections were common. Recommendations by midwives rarely included cytomegalovirus prevention.

    Conclusion: Parents have positive attitudes toward screening and prevention of congenital cytomegalovirus infection, despite a predicted increase in stress. Information is not being conveyed by prenatal providers about how to protect oneself against cytomegalovirus infection, which reflects a lack of hygiene routines during pregnancy related to its prevention.

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  • Veerabhadraswamy, Priyadarshini
    et al.
    Indian Inst Sci IISc, Dept Dev Biol & Genet DBG, Cell Metab Lab GA 08, Bengaluru, India..
    Lata, Kiran
    Indian Inst Sci, Mol Biophys Unit, Bengaluru, Karnataka, India.;Indian Inst Sci, Ctr Infect Dis Res, Bengaluru, Karnataka, India..
    Dey, Sristi
    Indian Inst Sci IISc, Dept Dev Biol & Genet DBG, Cell Metab Lab GA 08, Bengaluru, India..
    Belekar, Prajakta
    Univ Gothenburg, Inst Neurosci & Physiol, Unit Metab Physiol, Gothenburg, Sweden..
    Kothegala, Lakshmi
    Indian Inst Sci IISc, Dept Dev Biol & Genet DBG, Cell Metab Lab GA 08, Bengaluru, India.;Univ Gothenburg, Inst Neurosci & Physiol, Unit Metab Physiol, Gothenburg, Sweden..
    Mangala Prasad, Vidya
    Indian Inst Sci, Mol Biophys Unit, Bengaluru, Karnataka, India.;Indian Inst Sci, Ctr Infect Dis Res, Bengaluru, Karnataka, India..
    Gandasi, Nikhil
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology. Indian Inst Sci IISc, Dept Dev Biol & Genet DBG, Cell Metab Lab GA 08, Bengaluru, India.;Univ Gothenburg, Inst Neurosci & Physiol, Unit Metab Physiol, Gothenburg, Sweden..
    Comparison of localization and release of multivesicular bodies and secretory granules in islet cells: Dysregulation during type-2 diabetes2024In: JOURNAL OF EXTRACELLULAR BIOLOGY, ISSN 2768-2811, Vol. 3, no 11, article id e70014Article in journal (Refereed)
    Abstract [en]

    Multivesicular bodies (MVBs) are vesicles of endosomal origin containing intraluminal vesicles, which upon fusion with plasma membrane, secrete exosomes. They play a significant role in the physiology and pathology of type-2 diabetes (T2D) due to disrupted intercellular communication. The role of MVBs and their influence on insulin secretory granules (ISGs) of beta-cells or their characterization is yet to be uncovered. In our study, we compared MVBs to largely well-characterized ISGs in beta-cells. This study compares the density, localization, and exocytosis of CD63+ compartments (CD63+c) with NPY labelled ISGs (NISGs) in beta-cells. For this, tetraspanin CD63 was exploited to majorly label MVBs in beta-cells. These labels preserve the structural integrity of labelled compartments and mostly do not localize with other endo-lysosomal compartments. This study showed that the beta-cells have a significantly higher density of NISGs than CD63+c. CD63+c and NISGs are spatially localized apart within beta-cells. The proteins that localize with CD63+c are different from the ones that localize with NISGs. Exocytosis of NISGs occurs at the periphery of the beta-cells and takes significantly less time when compared to the release of CD63+c, which is non-peripheral and takes a longer duration. Mechanistically, the availability of CD63+c for exocytosis was assessed and found that an equilibrium is maintained between docking and undocking states at the plasma membrane. Although there are a high number of short-term residing, visiting CD63+c at the plasma membrane, the availability of CD63+c for exocytosis is maintained due to docking and undocking states. Further, a significant reduction in the density of NISGs and CD63+c was observed in beta-cells isolated from T2D donors compared to healthy counterparts. Studying the effect of MVBs on insulin secretion in physiological and T2D conditions has huge potential. This study provides a strong basis to open new avenues for such future studies.

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  • Weinmar, Franziska
    et al.
    Univ Tubingen, Tubingen Ctr Mental Hlth TuCMH, Dept Psychiat & Psychotherapy, Womens Mental Hlth & Brain Funct, Tubingen, Germany..
    Kogler, Lydia
    Univ Tubingen, Tubingen Ctr Mental Hlth TuCMH, Dept Psychiat & Psychotherapy, Womens Mental Hlth & Brain Funct, Tubingen, Germany.;German Ctr Mental Hlth DZPG, Partner Site Tubingen, Tubingen, Germany..
    Rehbein, Elisa
    German Inst Human Nutr, Dept Decis Neurosci & Nutr, Nuthetal, Germany.;Charite Univ Med Berlin, Berlin, Germany.;Free Univ Berlin, Humboldt Univ Berlin, Berlin, Germany.;Berlin Inst Hlth, Neurosci Res Ctr, Berlin, Germany.;German Ctr Diabet Res, Munchen Neuherberg, Germany..
    Morawetz, Carmen
    Univ Innsbruck, Dept Psychol, Innsbruck, Austria..
    Sundström Poromaa, Inger
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Reproductive Health.
    Skalkidou, Alkistis
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Obstetrics and Reproductive Health Research.
    Derntl, Birgit
    Univ Tubingen, Tubingen Ctr Mental Hlth TuCMH, Dept Psychiat & Psychotherapy, Womens Mental Hlth & Brain Funct, Tubingen, Germany.;German Ctr Mental Hlth DZPG, Partner Site Tubingen, Tubingen, Germany.;Univ Tubingen, LEAD Grad Sch & Res Network, Tubingen, Germany..
    Neural emotion regulation during pregnancy: An fMRI study investigating a transdiagnostic mental health factor in healthy first-time pregnant women2025In: IMAGING NEUROSCIENCE, ISSN 2837-6056, Vol. 3, article id imag_a_00529Article in journal (Refereed)
    Abstract [en]

    Pregnancy is a psycho-neuro-endocrinological transition phase presenting a window of vulnerability for mental health. Emotion regulation, a transdiagnostic factor for psychopathology, is influenced by estradiol across the menstrual cycle on the behavioral and neural level. Whether this is also the case in the antepartum period remains unknown. For the first time, behavioral and neural emotion regulation were investigated in healthy pregnant females with extremely high estradiol levels during the second trimester (N = 15) using a functional magnetic resonance imaging (fMRI) paradigm. Results were compared with naturally cycling females with high (N = 16) and low estradiol levels (N = 16). Although pregnant females reported the lowest trait use of cognitive reappraisal, all participants successfully regulated their emotions by applying cognitive reappraisal in the scanner. During downregulation of negative emotions, all females had increased activity in the left middle frontal gyrus. Pregnant females showed no significant differences in functional connectivity (psychophysiological interaction, resting-state) related to emotion regulation compared with the nonpregnant groups. However, group differences emerged for amygdala activation. In pregnant females, increased amygdala activity predicted reduced regulation success and was positively associated with depression scores. This first fMRI study during pregnancy indicates that depression scores are reflected in heightened amygdala activity already observable in the antepartum period. Thus, through its association with reduced regulation success, increased amygdala activity suggests a neural risk marker for peripartum mental health. The findings highlight the importance of investigating neural and behavioral emotion regulation in the ante- and postpartum period, eventually allowing enhanced identification, prevention, and treatment of peripartum mental ill-health.

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  • Humphreys, Anna B. C.
    et al.
    Karolinska Inst, Unit Epidemiol, Inst Environm Med, Stockholm, Sweden..
    Matthews, Anthony A.
    Karolinska Inst, Unit Epidemiol, Inst Environm Med, Stockholm, Sweden..
    Young, Jessica C.
    Karolinska Inst, Unit Epidemiol, Inst Environm Med, Stockholm, Sweden..
    Berglund, Anita
    Karolinska Inst, Unit Epidemiol, Inst Environm Med, Stockholm, Sweden..
    Lindahl, Bertil
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    Wettermark, Björn
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy. Vilnius Univ, Inst Biomed Sci, Fac Med, Pharm Ctr, Vilnius, Lithuania..
    Dahabreh, Issa J.
    Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, CAUSALab, Boston, MA USA.;Harvard TH Chan Sch Publ Hlth, Dept Biostat, Boston, MA USA.;Beth Israel Deaconess Med Ctr, Richard A & Susan F Smith Ctr Outcomes Res, Boston, MA USA..
    Kahan, Thomas
    Karolinska Inst, Danderyd Hosp, Dept Clin Sci, Div Cardiovasc Med, Stockholm, Sweden..
    Hernan, Miguel A.
    Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, CAUSALab, Boston, MA USA.;Harvard TH Chan Sch Publ Hlth, Dept Biostat, Boston, MA USA..
    The definition of treatment assignment in observational emulations of target trials - an empirical examination in the Swedish Primary Care Cardiovascular Database2025In: Annals of Epidemiology, ISSN 1047-2797, E-ISSN 1873-2585, Vol. 108, p. 56-62Article in journal (Refereed)
    Abstract [en]

    Background: In randomized trials, the intention-to-treat effect is the effect of assignment to treatment strategies. The concept of assignment may not be clearly defined when using observational data to emulate a target trial.

    Aims: We aimed to assess the practical implications of using data on prescription versus dispensation as analogues of treatment assignment in observational analyses.

    Methods: We used the primary care-derived Swedish Primary Care Cardiovascular Database of individuals with newly diagnosed hypertension between 2006 and 2014 and linked registers. We compared the effect of two antihypertensive drug classes on the five-year risk of cancer and ischemic heart disease. Treatment assignment was first mapped using prescription data, and then dispensation data. With unique confounding structures, we sequentially adjusted for different classes of risk factor due to uncertainty over the choice of relevant confounders for prescription vs. dispensation.

    Results: 7770 individuals were eligible when assignment was defined using prescription compared with 5964 when defined using dispensation. For both cancer and ischemic heart disease outcomes, both higher and lower relative risks of the outcome were consistent with our data. Effect estimates did not vary with the choice of prescription or dispensation data as analogues of assignment, nor with sequential adjustment for class of risk factor.

    Conclusion: The mapping of prescription or dispensation data to treatment assignment influences the size and characteristics of the study population and the structure of confounding. However, we found no clear numerical differences in effect estimates in this study. Further investigation is required in other settings.

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  • Hoiby, Pernilla
    et al.
    Lund Univ, Dept Clin Sci Malmö, Div Geriatr Med, Malmö, Sweden..
    Zarrouk, Moncef
    Lund Univ, Dept Clin Sci Malmö, Div Vasc Med, Malmö, Sweden..
    Lind, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Epidemiology.
    Sundström, Johan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Epidemiology.
    Elmstahl, Solve
    Lund Univ, Dept Clin Sci Malmö, Div Geriatr Med, Malmö, Sweden..
    Prevalence of atrial fibrillation among Swedish adults participating in the general population study EpiHealth2025In: Scandinavian Cardiovascular Journal, ISSN 1401-7431, E-ISSN 1651-2006, Vol. 59, no 1, article id 2526044Article in journal (Refereed)
    Abstract [en]

    Objectives: This study aimed to estimate the prevalence of atrial fibrillation (AF) and identify its associated comorbidities in adults aged 45 years and older, using data from the Swedish general population study EpiHealth.

    Design: In a cross-sectional design, data of health history, lifestyle factors, anthropometric measurement, and 1-lead ECG recordings from participants in the EpiHealth study were linked to data from the Swedish Patient Registry.

    Results: Among the 22,616 participants (56.2% women), the overall prevalence of AF was 3.9%, of which 0.3% were newly diagnosed cases identified by single 1-lead ECG at cohort examination. AF prevalence was higher in men than in women across all age groups and increased with age, reaching 17.2% among men aged 75 years and older. Participants with AF had a higher prevalence of cardiovascular comorbidities compared to those without AF.

    Conclusions: The findings highlight the increasing prevalence of AF with advancing age and its higher occurrence in men compared to women. The screening-detected prevalence of AF of 0.3% among participants in this general population study suggests that simple 1-lead ECG could be a manageable approach to screen for AF. The strong association between AF and cardiovascular comorbidities emphasizes the need for management strategies to address this condition, particularly in older adults.

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  • Mboya, Innocent B.
    et al.
    Lund Univ, Dept Translat Med, Malmö, Sweden.;Africa Acad Publ Hlth AAPH, Dar Es Salaam, Tanzania.;KCMC Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Moshi, Tanzania..
    Fritz, Josef
    Lund Univ, Dept Translat Med, Malmö, Sweden.;Med Univ Innsbruck, Inst Clin Epidemiol Publ Hlth Hlth Econ Med Stat &, Innsbruck, Austria..
    Scilipoti, Pietro
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences. IRCCS San Raffaele Hosp, Div Expt Oncol, Unit Urol, URI Inst, Milan, Italy..
    Haggstrom, Christel
    Umeå Univ, Northern Registry Ctr, Dept Diagnost & Intervent, Umeå, Sweden..
    da Silva, Marisa
    Lund Univ, Dept Translat Med, Malmö, Sweden.;Halmstad Univ, Sch Informat Technol, Halmstad, Sweden..
    Sun, Ming
    Lund Univ, Dept Translat Med, Malmö, Sweden..
    Wahlstrom, Jens
    Umeå Univ, Dept Epidemiol & Global Hlth, Umeå, Sweden..
    Oskarsson, Viktor
    Umeå Univ, Dept Publ Hlth & Clin Med, Pitea Res Unit, Pitea, Sweden..
    Michaëlsson, Karl
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Medical epidemiology.
    Leppert, Jerzy
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Disciplinary Domain of Medicine and Pharmacy, research centers etc., Centre for Clinical Research, County of Västmanland.
    Chabok, Abbas
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Disciplinary Domain of Medicine and Pharmacy, research centers etc., Centre for Clinical Research, County of Västmanland.
    Magnusson, Patrik K. E.
    Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden..
    Lagerros, Ylva Trolle
    Karolinska Inst, Dept Med, Div Clin Epidemiol, Solna, Stockholm, Sweden.;Stockholm Hlth Serv, Ctr Obes, Acad Specialist Ctr, Stockholm, Sweden..
    Bonn, Stephanie E.
    Karolinska Inst, Dept Med, Div Clin Epidemiol, Solna, Stockholm, Sweden..
    Hedman, Linnea
    Umeå Univ, Dept Publ Hlth & Clin Med, OLIN Unit, Umeå, Sweden..
    Stattin, Pär
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Urology.
    Stocks, Tanja
    Lund Univ, Dept Translat Med, Malmö, Sweden..
    Association of height, BMI, and smoking status with prostate cancer risk before and after the introduction of PSA testing in Sweden2025In: Scientific Reports, E-ISSN 2045-2322, Vol. 15, no 1, article id 20290Article in journal (Refereed)
    Abstract [en]

    Prostate cancer (PCa) incidence has steadily increased in Sweden, more steeply in the mid-1990s caused by increased opportunistic prostate-specific antigen (PSA) testing. Tallness, normal weight, and non-smoking are associated with more PSA testing, which increases detection of low-risk and localised PCa. We investigated time trends of height, body mass index (BMI), and smoking with PCa risk in 171,889 men in Sweden aged 50-64 years at baseline, who were linked to nationwide cancer registers during follow-up. Cox regression determined the association of these factors assessed before 1980, 1980-1994, and 1995-2004 with PCa risk. During 15 follow-up years, 8,049 men were diagnosed with PCa. The association of height with PCa was weakly positive across all calendar periods. For obesity (BMI >= 30 kg/m2) vs. normal weight (BMI 18.5-24.9 kg/m2) and current vs. never smoking, the associations changed from null before 1980 (HR 1.03, 95% CI 0.86-1.23, and 1.11, 95% CI 0.97-1.27) to negative in 1995-2004 (HR 0.83, 95% CI 0.74-0.93, and 0.86, 95% CI 0.79-0.93; pinteraction between periods = 0.05 and 0.001). In men with clinical characteristics available, height was positively associated with both aggressive and non-aggressive PCa whilst obesity and smoking showed negative associations only with non-aggressive PCa. These findings likely reflect differences in PSA testing by BMI and smoking habits and contribute important knowledge for etiological studies of PCa.

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  • Hellgren, Mikko
    et al.
    Örebro Univ Hosp, Univ Hlth Care Res Ctr, Örebro, Sweden.;Örebro Univ, Sch Med Sci, Örebro, Sweden..
    Boström, Kristina Bengtsson
    Univ Gothenburg, Inst Med, Sahlgrenska Acad, Sch Publ Hlth & Community Med, Gothenburg, Sweden..
    Hedin, Katarina
    Reg Jönköping Cty, Futurum, Jönköping, Sweden.;Linköping Univ, Dept Hlth Med & Caring Sci, Linköping, Sweden.;Lund Univ, Dept Clin Sci Malmö, Family Med, Malmö, Sweden..
    Jansson, Stefan P. O.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, General practice. Örebro Univ Hosp, Univ Hlth Care Res Ctr, Örebro, Sweden.;Örebro Univ, Sch Med Sci, Örebro, Sweden..
    Nilsson, Staffan
    Linköping Univ, Dept Hlth Med & Caring Sci, Linköping, Sweden..
    Nilsson, Gunnar
    Karolinska Inst, Div Family Med & Primary Care, Dept Neurobiol Care Sci & Soc, Huddinge, Sweden..
    Wändell, Per
    Umeå Univ, Dept Publ Hlth & Clin Med Family Med, Umeå, Sweden..
    Wennberg, Patrik
    Karolinska Inst, Div Family Med & Primary Care, Dept Neurobiol Care Sci & Soc, Huddinge, Sweden..
    Large Variation in Adherence to Diagnostic Guidelines in Hypertension Management in Swedish Primary Healthcare2025In: The Journal of Clinical Hypertension, ISSN 1524-6175, E-ISSN 1751-7176, Vol. 27, no 6, article id e70079Article in journal (Refereed)
    Abstract [en]

    High blood pressure (BP) is a frequent cause for visits to primary healthcare centers (PHCCs) in Sweden. Guidelines on methods for BP measurements for diagnosis of hypertension have recently been updated. We aimed to study adherence to diagnostic guidelines in hypertension management and evaluate whether adherence to guidelines was related to organizational or sociodemographic characteristics. Interviews with representatives from 76 randomly selected PHCCs from eight regions in Sweden were conducted. PHCCs' use of 24-h ambulatory BP monitoring (ABPM), home BP monitoring (HBPM) and BP measurements in both arms for the diagnosis of hypertension were chosen as proxy markers for adherence to diagnostic guidelines. An adherence index was created as a composite score of these diagnostic methods. The proportion of PHCCs stating they "often use" ABPM and HBPM were 13.7% and 16.0%, respectively, and 57.3% stated they performed BP measurements in both arms. Two PHCCs did not use ABPM, HBPM or BP measurements in both arms to diagnose hypertension. None of the organizational or sociodemographic characteristics (number of listed patients, Care Need Index (CNI), geographical location, ownership, investigation primarily led by doctor/nurse, dedicated team management, special training for hypertension and local routines) were associated with the adherence index. This study shows that adherence to diagnostic guidelines vary largely between PHCCs. No organizational characteristic, not even team-based management, was associated with adherence to diagnostic guidelines. The variation raises questions about inequity healthcare and novel strategies that may be needed to improve PHCCs' adherence to diagnostic guidelines in hypertension management. 

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  • Lee, Earric
    et al.
    Univ Jyvaskyla, Fac Sport & Hlth Sci, Jyvaskyla, Finland.;Montreal Heart Inst, Montreal, PQ, Canada.;Univ Montreal, Ecole Kinesiol & Sci Act Phys, Montreal, PQ, Canada..
    Ketelhut, Sascha
    Univ Bern, Inst Sport Sci, Bremgartenstr 145, CH-3012 Bern, Switzerland..
    Wiklund, Petri
    Shanghai Jiao Tong Univ, Exercise Translat Med Ctr, Shanghai, Peoples R China.;Shanghai Jiao Tong Univ, Shanghai Ctr Syst Biomed, Shanghai, Peoples R China..
    Kostensalo, Joel
    Nat Resources Inst Finland Luke, Joensuu, Finland..
    Kolunsarka, Iiris
    Univ Jyvaskyla, Fac Sport & Hlth Sci, Jyvaskyla, Finland..
    Hägglund, Hans
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Haematology. Karolinska Univ Hosp Huddinge, Karolinska Comprehens Canc Ctr, Dept Cellular Therapy & Allogene Stem Cell Transpl, Stockholm, Sweden..
    Ahtiainen, Juha P.
    Univ Jyvaskyla, Fac Sport & Hlth Sci, Jyvaskyla, Finland..
    Regular postexercise sauna bathing does not improve heart rate variability: A multi-arm randomized controlled trial2025In: Physiological Reports, E-ISSN 2051-817X, Vol. 13, no 13, article id e70449Article in journal (Refereed)
    Abstract [en]

    Regular exercise has been shown to increase heart rate variability (HRV) for different populations. Acute and short-term studies using heat therapy and sauna bathing have also shown HRV improvements. However, long-term adaptations in HRV to regular exercise and sauna bathing remain unexplored. In this 1:1:1 multi-arm trial, sedentary participants (n = 38) aged 49 ± 9 years with at least one CVD risk factor were randomly assigned to regular exercise and 15-min postexercise sauna (EXS), regular exercise only (EXE), or control (CON) group, for an 8-week intervention. Indices of HRV (RR interval, RMSSD, SDNN, resting heart rate [HR], HRMAX-HRMIN, high frequency power [HFP], and low frequency power [LFP]) were measured before (PRE) and after (POST) the trial. Compared to CON, EXE increased the time-domain measure of HRMAX-HRMIN (p = 0.003), and elicited significantly smaller decreases in the frequency-domain measure of LFP (p = 0.022). There were no statistically significant differences between EXS and EXE for any of the HRV indices measured. Eight weeks of regular exercise conferred positive changes in both time- and frequency-domain measures of HRV. However, adding regular sauna bathing postexercise offered no additional benefits to HRV over regular exercise alone.

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  • Holmes, Scott A.
    et al.
    Harvard Med Sch, Boston Childrens Hosp, Dept Anesthesia Critical Care and & Med, Pediat Pain Pathway Lab, Boston, MA 02115 USA.;Harvard Med Sch, Boston Childrens Hosp, Dept Anesthesiol Crit Care & Pain Med, Boston, MA 02115 USA..
    Faria, Vanda
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology. Harvard Med Sch, Boston Childrens Hosp, Dept Anesthesiol Crit Care & Pain Med, Boston, MA 02115 USA.;Harvard Med Sch, Boston Childrens Hosp, Dept Anesthesia Critical Care & Pain Med, Brain & Eye Pain Imaging Lab, Boston, MA USA..
    Moulton, Eric A.
    Harvard Med Sch, Boston Childrens Hosp, Dept Anesthesiol Crit Care & Pain Med, Boston, MA 02115 USA.;Harvard Med Sch, Boston Childrens Hosp, Dept Anesthesia Critical Care & Pain Med, Brain & Eye Pain Imaging Lab, Boston, MA USA.;Harvard Med Sch, Boston Childrens Hosp, Dept Ophthalmol, Boston, MA USA..
    Generative AI in healthcare: challenges to patient agency and ethical implications2025In: Frontiers in Digital Health, E-ISSN 2673-253X, Vol. 7, article id 1524553Article in journal (Refereed)
    Abstract [en]

    Clinical research is no longer a monopolistic environment wherein patients and participants are the sole voice of information. The introduction and acceleration of AI-based methods in healthcare is creating a complex environment where human-derived data is no longer the sole mechanism through which researchers and clinicians explore and test their hypotheses. The concept of self-agency is intimately tied into this, as generative data does not encompass the same person-lived experiences as human-derived data. The lack of accountability and transparency in recognizing data sources supporting medical and research decisions has the potential to immediately and negatively impact patient care. This commentary considers how self-agency is being confronted by the introduction and proliferation of generative AI, and discusses future directions to improve, rather than undermine AI-fueled healthcare progress.

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  • Cheung, Kingman
    et al.
    Natl Tsing Hua Univ, Dept Phys, Hsinchu 300, Taiwan.;Natl Tsing Hua Univ, CTC, Hsinchu 300, Taiwan.;Konkuk Univ, Sch Phys, Div Quantum Phases & Devices, Seoul 143701, South Korea..
    Mao, Ying-nan
    Wuhan Univ Technol, Sch Phys & Mech, Dept Phys, Wuhan 430070, Hubei, Peoples R China..
    Moretti, Stefano
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics. Univ Southampton, Sch Phys & Astron, Southampton SO17 1BJ, England..
    Zhang, Rui
    Inst High Energy Phys, Theoret Phys Div, Beijing 100049, Peoples R China.;Shanghai Inst Satellite Engn, Shanghai Key Lab Deep Space Explorat Technol, 3666 Yuanjiang Rd, Shanghai 201109, Peoples R China..
    Testing CP-violation in a heavy Higgs sector at CLIC2025In: European Physical Journal C, ISSN 1434-6044, E-ISSN 1434-6052, Vol. 85, article id 700Article in journal (Refereed)
    Abstract [en]

    We propose a method for probing CP-violation in the heavy (pseudo)scalar sector of an extended Higgs model, in which we make simultaneous use of the HVV (V=W±,Z) and Htt<overline> interactions of a heavy Higgs state H. The CP-even component of H can be probed through the tree-level HVV interaction, while the CP-odd component of H can be probed if the final tt<overline> pair can be tested to form a 1S0 state. We can then confirm CP-violation if both CP-even and CP-odd components of H are discovered. This is possible at the Compact Linear Collider (CLIC) by exploiting H production from vector-boson fusion (VBF) and decay to tt<overline> pairs. We analyze the distribution of the azimuthal angle between the leptons coming from top and antitop quarks, which allows one to disentangle the CP nature of such a heavy Higgs state. We also show its implications for the two-Higgs-doublet model (2HDM) with CP-violation.

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  • Helou, Ramzy I.
    et al.
    Erasmus Med Ctr, Dept Med Microbiol & Infect Dis, Rotterdam, Netherlands.;Erasmus MC, Dept Med Microbiol & Infect Dis, Med Microbiol & Infect Dis, Room Na-918, POB 2040, NL-3000 CA Rotterdam, Netherlands..
    Catho, Gaud
    Univ Geneva, Geneva Univ Hosp, Div Infect Dis, Geneva, Switzerland.;Univ Geneva, Fac Med, Geneva, Switzerland.;Univ Geneva, Geneva Univ Hosp, Infect Control Div, Geneva, Switzerland.;Valais Hosp, Cent Inst, Div Infect Dis, Sion, Switzerland..
    Faxén, Lisa
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    Hulscher, Marlies
    Radboud Univ, IQ Hlth Sci Dept, Med Ctr, Nijmegen, Netherlands..
    Teerenstra, Steven
    Radboud Univ, Med Ctr, IQ Hlth Sci Dept, Grp Biostat, Nijmegen, Netherlands..
    Conly, John
    Univ Calgary, Synder Inst Chron Dis, Cumming Sch Med, Dept Med, Calgary, AB, Canada.;Univ Calgary, Synder Inst Chron Dis, Cumming Sch Med, Dept Microbiol, Calgary, AB, Canada.;Univ Calgary, Synder Inst Chron Dis, Cumming Sch Med, Dept Immunol & Infect Dis, Calgary, AB, Canada.;Univ Calgary, Synder Inst Chron Dis, Cumming Sch Med, Dept Pathol & Lab Med, Calgary, AB, Canada.;Univ Calgary, OBrien Inst Publ Hlth, Cumming Sch Med, Calgary, AB, Canada.;Alberta Hlth Serv, Calgary, AB, Canada..
    Huttner, Benedikt D.
    Univ Geneva, Geneva Univ Hosp, Div Infect Dis, Geneva, Switzerland.;Univ Geneva, Fac Med, Geneva, Switzerland..
    Tängdén, Thomas
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Infection medicine.
    Verbon, Annelies
    Erasmus Med Ctr, Dept Med Microbiol & Infect Dis, Rotterdam, Netherlands..
    Impact of a smartphone application for appropriate antibiotic prescribing at three tertiary hospitals: an international, multicentre stepped-wedge cluster randomized trial2025In: Clinical Microbiology and Infection, ISSN 1198-743X, E-ISSN 1469-0691, Vol. 31, no 7, p. 1172-1179Article in journal (Refereed)
    Abstract [en]

    Objectives: Smartphone applications (apps) for antibiotic prescribing have been studied in observational studies. Here, we assessed whether the use of a smartphone app increased appropriate antibiotic therapy (AAT) in hospitals.

    Methods: An antibiotic stewardship app (Firstline.org) was populated with local guidelines and tested in a stepped-wedged cluster randomized trial in three hospitals in the Netherlands, Sweden, and Switzerland. Defined clusters were randomized per hospital for the intervention (use of app) or standard of care. Primary outcome was AAT assessed by chart review in 15 random patients per cluster per intervention period. Secondary outcomes included clinical outcomes and user analytics. A questionnaire identifying barriers to app use was disseminated. Multivariable multilevel logistic models with time periods as fixed effects to adjust for time trend and treatment as fixed effects were employed to estimate the odds ratio of treatment.

    Results: Twelve clusters in the Netherlands (1085 patients) were included, 12 in Sweden (362 patients) and 8 in Switzerland (653 patients). Overall, AAT was not increased (2.0% [95% CI,-5.92% to 9.97%]) in the intervention arm compared with control across the three centres. Mean frequency of app use by cluster was associated with an AAT increase (1.9% [95% CI, 1.18-2.62%]) across study centres; 3.2% in the Netherlands (p < 0.01), 2.8% in Switzerland (p < 0.01), and remained similar in Sweden (0.4%; p 0.46). No difference was found for the other secondary outcomes. Main barriers for app use reported in the questionnaire were easily forgetting using the app and having other tools to help prescribing antibiotics.

    Discussion: Overall, the introduction of a stewardship app did not significantly increase AAT, but a prespecified secondary analysis of app use frequency was associated with a small but significant improvement of AAT. Variable uptake of the app, coexisting routes to guidelines and the impact of the COVID-19 pandemic during the trial likely had an impact on the results.

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  • Abdulla, Parosh Aziz
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Computer Systems. Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Division of Computer Systems.
    A Symbolic Approach to Verifying Quantum Systems2025In: Communications of the ACM, ISSN 0001-0782, E-ISSN 1557-7317, Vol. 68, no 6, p. 84-84Article in journal (Other academic)
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  • Khan, Afia Mahmuda
    et al.
    North South Univ, Dept Publ Hlth, Dhaka 1229, Bangladesh.;Int Ctr Diarrheal Dis Res Bangladesh IcddrB, Maternal & Child Hlth Div MCHD, Dhaka 1212, Bangladesh.;Publ Hlth Promot & Dev Soc PPDS, Dhaka 1205, Bangladesh..
    Dalal, Koustuv
    Mid Sweden Univ, Sch Hlth Sci, Div Publ Hlth Sci, S-85170 Sundsvall, Sweden.;Univ Johannesburg, ZA-2902 Johannesburg, South Africa..
    Eusufzai, Sumaiya Zabin
    Univ Sains Malaysia, Sch Dent Sci, Kota Baharu 16150, Kelantan, Malaysia..
    Shohid, Sabrin
    Natl Inst Prevent & Social Med NIPSOM, Dept Publ Hlth & Hosp Adm, Dhaka 1212, Bangladesh..
    Das, Rinku
    North South Univ, Dept Publ Hlth, Dhaka 1229, Bangladesh..
    Hossain, Sheikh Jamal
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, International Child Health and Nutrition. Univ Sains Malaysia, Sch Dent Sci, Kota Baharu 16150, Kelantan, Malaysia..
    Shahed, Lameea
    North South Univ, Dept Publ Hlth, Dhaka 1229, Bangladesh..
    Alam, Turia
    Univ Wollongong, Wollongong, NSW 2522, Australia..
    Ferdous, Kazi Sayma
    North South Univ, Dept Publ Hlth, Dhaka 1229, Bangladesh..
    Hawlader, Mohammad Delwer Hossain
    North South Univ, Dept Publ Hlth, Dhaka 1229, Bangladesh.;North South Univ, NSU Global Hlth Inst NGHI, Dhaka 1229, Bangladesh..
    Comparative analysis of emotional and behavioral problems among adolescent offspring of female sex workers and residents of urban slum, Bangladesh2025In: DISCOVER MENTAL HEALTH, ISSN 2731-4383, Vol. 5, article id 93Article in journal (Refereed)
    Abstract [en]

    Introduction: The children of female sex workers are the victims of their circumstances from the beginning and are deprived of an environment that encourages optimal physical and psychological development. This study aimed to assess the prevalence of emotional and behavioral problems among adolescent offspring of female sex workers and compare that with adolescent offspring of slum-dwellers in Daulatdia and Dhaka city, Bangladesh.

    Methods: A cross-sectional study was conducted with a sample of 394 adolescent children (196 adolescent offspring of sex workers and 198 adolescent offspring of slum dwellers) from March 2024 to May 2024 using a structured questionnaire. The study was conducted through face-to-face interviews where sociodemographic details, along with information regarding emotional and behavioral health problems, were assessed through the Strength and Difficulties Questionnaire (SDQ) scale, and health-related quality of life was assessed through the Kidscreen-10 scale. Descriptive analysis, bivariate analysis, and binary logistic regression analysis were performed.

    Results: The prevalence of emotional and behavioral problems was 13% for adolescent offspring of Daulatdia and 15% for Korail slum. Age and gender in brothel settings and HRQoL in both settings were found to be significantly associated with emotional and behavioral difficulties. Adolescent offspring of FSWs with low HRQoL (OR = 4.09, p-value < 0.05, CI 1.579-10.595) were 4.09 times more likely to suffer from abnormal mental disorders than those with average or high HRQoL. While in a slum setting, it is 2.825 times higher (OR = 2.825, p-value < 0.05, CI 1.142-6.987).

    Conclusion: The study concluded that the overall prevalence of emotional and behavioral problems for adolescent offspring of FSWs was significantly lower than for adolescent offspring of slum dwellers in the emotional problem subscale. Tailored interventions should be developed to address the specific needs of individuals with emotional and behavioral health problems while minimizing the detrimental impacts of their stigmatized identity.

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  • Yadavalli, Tejabhiram
    et al.
    Univ Illinois, Dept Ophthalmol & Visual Sci, Chicago, IL USA..
    Awasthi, Sita
    Univ Penn, Perelman Sch Med, Dept Med, Infect Dis Div, Philadelphia, PA USA..
    Li, Jinlin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology, Infection and Immunity.
    Editorial: Herpesvirus: transmission, pathogenesis, host-pathogen interaction, and treatment2025In: Frontiers in Microbiology, E-ISSN 1664-302X, Vol. 16, article id 1637344Article in journal (Other academic)
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  • Derraik, José G. B.
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Perinatal, Neonatal and Pediatric Cardiology Research. Univ Auckland, Fac Med & Hlth Sci, Sch Med, Dept Paediat Child & Youth Hlth, 85 Pk Rd, Auckland 1023, New Zealand.;Chiang Mai Univ, Res Inst Hlth Sci, Environm Occupat Hlth Sci & Noncommunicable Dis Re, Chiang Mai, Thailand.
    Hofman, Paul L.
    Univ Auckland, Liggins Inst, Auckland, New Zealand..
    The waiting game: when families decline - a brief commentary on delayed intervention in childhood obesity management2025In: Obesity, ISSN 1930-7381, E-ISSN 1930-739X, Vol. 33, no 7, p. 1215-1216Article in journal (Other academic)
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  • Okuno, Noriko
    et al.
    Univ Toyama, Acad Assembly Fac Med, Dept Pathol, Toyama 9300194, Japan..
    Yamamoto, Seiji
    Univ Toyama, Acad Assembly Fac Med, Dept Pathol, Toyama 9300194, Japan..
    Hamashima, Takeru
    Univ Toyama, Acad Assembly Fac Med, Dept Pathol, Toyama 9300194, Japan.;Toyama City Hosp, Dept Diagnost Pathol, Toyama 9398511, Japan..
    Dang, Tung Son
    Univ Toyama, Acad Assembly Fac Med, Dept Pathol, Toyama 9300194, Japan..
    Okita, Naruho
    Univ Toyama, Acad Assembly Fac Med, Dept Pathol, Toyama 9300194, Japan..
    Fujikawa, Miwa
    Univ Toyama, Acad Assembly Fac Med, Dept Pathol, Toyama 9300194, Japan..
    Kunisawa, Tomomi
    Univ Toyama, Acad Assembly Fac Med, Dept Pathol, Toyama 9300194, Japan..
    Takakura, Nobuyuki
    Osaka Univ, Res Inst Microbial Dis, Dept Signal Transduct, Suita, Osaka 5650871, Japan..
    Fujimori, Toshihiko
    Natl Inst Basic Biol, Div Embryol, Okazaki 4448787, Japan..
    Mori, Hisashi
    Univ Toyama, Acad Assembly Fac Med, Dept Mol Neurosci, Toyama 9300194, Japan..
    Betsholtz, Christer
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Vascular Biology. Karolinska Inst, Dept Med, S-14157 Huddinge, Sweden..
    Takata, Katsuyoshi
    Univ Toyama, Acad Assembly Fac Med, Dept Pathol, Toyama 9300194, Japan..
    Sasahara, Masakiyo
    Univ Toyama, Acad Assembly Fac Med, Dept Pathol, Toyama 9300194, Japan.;Toyama Saiseikai Hosp, Dept Pathol, Toyama 9318533, Japan..
    Brain macrophages and pial fibroblasts promote inflammation in a hypomyelination model2025In: Acta neuropathologica communications, E-ISSN 2051-5960, Vol. 13, article id 145Article in journal (Refereed)
    Abstract [en]

    Many neurological diseases remain difficult to treat, necessitating further elucidation of their pathogenesis. Conditional inactivation of Pdgfra in Nestin-expressing cells leads to the depletion of platelet-derived growth factor receptor-alpha+ (PDGFRα+) oligodendroglial lineage cells responsible for myelination, resulting in forebrain hypomyelination and severe, progressive neurological deficits in neonatal mice. The present study examined the cerebral cortex of these mice to better understand the mechanisms underlying such progressive neurological deficits, that are often observed in refractory neurological diseases. Histological and single-cell RNA sequencing analyses showed that, following activation of meningeal border-associated macrophages (BAMs), PDGFRα+ fibroblasts that escaped gene inactivation were extensively recruited from the meninges into the hypomyelinated subpial cerebral cortex. Transcriptional reprogramming suggested that these fibroblasts originated from the pial fibroblast lineage and adopted a myofibroblast-like transcriptional phenotype. The recruited fibroblasts established stable cell-cell interactions with activated brain macrophages, including BAMs and microglia, accompanied by signaling pathways associated with chronic, tissue-damaging inflammation. Subsequently, inflammatory cortical lesions emerged, characterized by glial activation, angiogenesis, and neuronal oxidative stress. Treatment with a PDGFRα-neutralizing antibody significantly reduced fibroblast recruitment and mitigated glial activation and angiogenesis. These findings suggest that meningeal BAMs and pial fibroblasts are key contributors to the formation of tissue-damaging subpial cortical lesions. The interactions between brain macrophages and pial fibroblasts may contribute to the mechanisms underlying chronic and progressive neurological deficits and represent potential therapeutic targets for refractory neurological diseases.

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  • Genestreti, K. J.
    et al.
    Southwest Res Inst, Earth Oceans & Space, Durham, NH 03824 USA..
    Nakamura, R.
    Austrian Acad Sci, Space Res Inst, Graz, Austria..
    Liu, Y. H.
    Dartmouth Coll, Dept Phys & Astron, Hanover, NH USA..
    Burch, J. L.
    Southwest Res Inst, Space Sci & Engn, San Antonio, TX USA..
    Norgren, Cecilia
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Swedish Institute of Space Physics, Uppsala Division. Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Space Plasma Physics.
    Shuster, J.
    Univ New Hampshire, Space Sci Ctr, Durham, NH USA..
    Hesse, M.
    NASA, Ames Res Ctr, Moffett Field, CA USA..
    Torbert, R. B.
    Southwest Res Inst, Earth Oceans & Space, Durham, NH 03824 USA.;Univ New Hampshire, Space Sci Ctr, Durham, NH USA..
    Chen, L. J.
    NASA, Goddard Space Flight Ctr, Greenbelt, MD USA..
    Heuer, S. V.
    Univ New Hampshire, Space Sci Ctr, Durham, NH USA..
    Structure of the Electron Diffusion Region During Magnetic Reconnection2025In: Space Science Reviews, ISSN 0038-6308, E-ISSN 1572-9672, Vol. 221, no 5, article id 59Article, review/survey (Refereed)
    Abstract [en]

    This article reviews recent developments in our understanding of the electron diffusion region (EDR) of magnetic reconnection, focusing on how the structure and dynamics of the EDR vary with the background plasma conditions. In particular, we highlight results from the Magnetospheric Multiscale (MMS) mission, a four-satellite NASA mission that measures plasma particles and electromagnetic fields in and around Earth's magnetosphere. Theoretical and modeling-driven predictions regarding the structure of the EDR and the key processes that enable reconnection are compared and contrasted with observational studies using in-situ MMS measurements.

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  • Stergiopoulou, Katerina
    et al.
    Univ Leicester, Sch Phys & Astron, Leicester, England..
    Sanchez-Cano, Beatriz
    Univ Leicester, Sch Phys & Astron, Leicester, England..
    Lester, Mark
    Univ Leicester, Sch Phys & Astron, Leicester, England..
    Fowler, Christopher M.
    West Virginia Univ, Dept Phys & Astron, Morgantown, WV USA..
    Andrews, David
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Swedish Institute of Space Physics, Uppsala Division.
    Xu, Shaosui
    Univ Calif Berkeley, Space Sci Lab, Berkeley, CA USA..
    Edberg, Niklas
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Swedish Institute of Space Physics, Uppsala Division.
    Joyce, Simon
    Univ Leicester, Sch Phys & Astron, Leicester, England..
    Holmström, Mats
    Swedish Inst Space Phys, Kiruna, Sweden..
    Halekas, Jasper S.
    Univ Iowa, Dept Phys & Astron, Iowa City, IA USA..
    Meggi, Dikshita
    Univ Leicester, Sch Phys & Astron, Leicester, England..
    Turner, Anna K.
    West Virginia Univ, Dept Phys & Astron, Morgantown, WV USA..
    Gruesbeck, Jacob R.
    NASA, Goddard Space Flight Ctr, Solar Syst Explorat Div, Greenbelt, MD USA..
    The Ionopause at Mars and Its Correlation With Magnetic Topology and Plasma Pressure2025In: Journal of Geophysical Research - Space Physics, ISSN 2169-9380, E-ISSN 2169-9402, Vol. 130, no 7, article id e2024JA032922Article in journal (Refereed)
    Abstract [en]

    We utilize Mars Atmosphere and Volatile Evolution (MAVEN) observations to investigate the ionopause boundary at Mars, the formation process of which is not yet well described. We focus on the eighth deep dip campaign (DD8), which consists of 50 consecutive orbits, and we develop an automated routine to identify ionopause boundaries in electron density and temperature data. We find ionopause boundaries in 54 out of 100 ionospheric crossings and an average ionopause altitude of 368 km. Having detected the ionopause boundaries, we then examine in detail all the DD8 orbits using complementary observations from several MAVEN instruments. We show examples of two orbits, illustrating how the shapes of the topside ionosphere and ionopause can differ among ionospheric crossings and how the ionopause formation is correlated with changes in magnetic topology and the plasma pressure balance between the ionosphere and the magnetic pile-up region (MPR). We find that 70% of the detected ionopauses are formed where there are changes in magnetic topology, particularly from closed to either open or draped magnetic field lines, and 80% of the boundaries are also formed where the ionospheric plasma pressure becomes equal to the plasma pressure of the MPR. Finally, we confirm that the ionopause boundary is more likely to be formed under high solar wind dynamic pressure conditions.

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  • Montagud-Camps, Victor
    et al.
    Univ Murcia, Dept Electromagnetism & Elect, Murcia, Spain..
    Toledo-Redondo, Sergio
    Univ Murcia, Dept Electromagnetism & Elect, Murcia, Spain..
    Goldstein, Jerry
    Southwest Res Inst, Space Sci & Engn Div, San Antonio, TX USA..
    Fuselier, Stephen A.
    Southwest Res Inst, Space Sci & Engn Div, San Antonio, TX USA..
    André, Mats
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Swedish Institute of Space Physics, Uppsala Division.
    Albert, Inmaculada F.
    Univ Murcia, Dept Electromagnetism & Elect, Murcia, Spain..
    Castilla, Aida
    Univ Murcia, Dept Electromagnetism & Elect, Murcia, Spain..
    Salinas, Alfonso
    Univ Granada, Dept Electromagnetism & Matter Phys, Granada, Spain..
    Porti, Jorge
    Univ Granada, Dept Appl Phys, Granada, Spain..
    Navarro, Enrique A.
    Univ Valencia, IRTIC Inst, Paterna, Spain..
    Statistical Analysis of the Warm Plasma Cloak in the Dayside Magnetosphere: 9 Years of MMS Observations2025In: Geophysical Research Letters, ISSN 0094-8276, E-ISSN 1944-8007, Vol. 52, no 13, article id e2025GL116933Article in journal (Refereed)
    Abstract [en]

    The warm plasma cloak (WPC) is a plasma population located in the outer magnetosphere. It is composed primarily of electrons and H+ ions with energies of tens to hundreds electronvolts and can contain significant amounts of O+. We conduct a statistical survey of the WPC using 9 years of observations in the dayside magnetosphere from the Magnetospheric Multiscale mission. WPC is found in 51% of the observations and it is 1.6 times more abundant in the dawn than in the dusk sector. O+-rich WPC is detected in 7.5% of the observations, being 3 times more probable in the dawn sector. We find that after a peak of strong geomagnetic activity, it takes approximately 9 hr to detect the WPC in the dayside magnetosphere.

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  • Frankenhaeuser, Freja
    et al.
    Department of Oral and Maxillofacial Diseases University of Helsinki Helsinki Finland.
    Källmén, Håkan
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology. Uppsala University Uppsala Sweden.
    Meurman, Jukka
    Department of Oral and Maxillofacial Diseases University of Helsinki Helsinki Finland.
    Korpi, Esa
    Department of Pharmacology University of Helsinki Helsinki Finland.
    Söder, Birgitta
    Department of Dental Medicine Karolinska Institutet Solna Sweden.
    Medication Purchases Are Associated With the Number of Dental Treatments2025In: Clinical and Experimental Dental Research, E-ISSN 2057-4347, Vol. 11, no 3, article id e70121Article in journal (Refereed)
    Abstract [en]

      Objectives

    Little is known whether the number of systemic medications, indicating worsened general health, affects the number of dental appointments needed. The hypothesis is that patients purchasing more systemic medications would have an increased number of dental appointments and respective need for treatments than patients who do not purchase as many medications.

    Materials and Methods

    Our cohort consists of 1495 participants from the Stockholm area, Sweden, initially examined in 1985. Using national population and patient registers (2005–2017), the association between the number of medication purchases and dental appointments was analyzed. The Anatomical Therapeutic Chemical Classification System for Medicines (ATC) was used. Descriptive statistics, chi-square tests, and logistic regressions were used with several covariates like gender and socioeconomic status.

    Results

    Purchases above the median of all medications showed a statistically significant association with more dental appointments and respective treatments. Most of the ATC system's main drug categories were significantly associated with more dental appointments, even when adjusting for covariates. Purchases of medications from 32 different ATC subgroups were significantly associated with the number of dental appointments above the median.

    Conclusion

    In the group of adult Swedes who were studied, it was found that increased purchasing of nearly all types of drugs was associated with an increased number of dental appointments between the study years 2005–2017.

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  • Public defence: 2025-09-05 13:00 I:101, Hus I, Linköping
    Bäck, Malin
    Linköping University, Department of Behavioural Sciences and Learning, Psychology. Linköping University, Faculty of Arts and Sciences. Region Jönköping.
    Relational Aspects and Applications of Interpersonal Psychotherapy for Eating disorders with Co-morbid Depression2025Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Interpersonal Psychotherapy (IPT), originally developed for depression, is recommended in Sweden’s national treatment guidelines as an option for binge eating disorder and bulimia nervosa. Despite documented efficacy, IPT has primarily been studied as a comparison treatment in eating disorder research. There remains limited knowledge about the method’s functioning in Swedish clinical settings, the mechanisms of change, and how therapeutic work unfolds in practice. This thesis, using a mixed method design, examines the applicability of IPT for individuals with eating disorders and co-occurring depression. The results indicate that IPT is a promising treatment for patients within the bulimic spectrum, showing significant improvements in both eating disorder and depressive symptoms. Notably, improvements in depression preceded symptom relief in the eating disorder – but not the other way around – suggesting a potentially change-driving association. Symptom improvement occurred more rapidly when treatment explicitly and consistently linked current symptoms to emotionally charged relational themes. The qualitative findings demonstrate that this connection – the so-called mood-event connection – is co-created through a collaborative process, in which therapist and patient jointly develop an understanding of what is meaningful and what the next step in therapy should be. Patients with a more restrictive symptomatology showed no improvement. This may possibly be explained by patients’ descriptions of living with the eating disorder as something ever-present in the relating to themselves, others, and life as a whole. The findings suggest that treatment should support the externalisation of the eating disorder as an ego-dystonic condition, foster more functional ways of relating to self and others, and facilitate motivation for a new social role beyond the illness. This thesis supports IPT as a credible and independent treatment for eating disorders, especially in cases involving binge eating, compensatory behaviours, and co-occurring depression.

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  • Smith, Katharine A.
    et al.
    Univ Oxford, Dept Psychiat, Oxford, England.;Warneford Hosp, Oxford Hlth NHS Fdn Trust, Oxford, England.;NIHR Oxford Hlth Biomed Res Ctr, Oxford Precis Psychiat Lab, Oxford, England..
    Ward, Thomas
    Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychol, London, England.;South London & Maudsley NHS Fdn Trust, London, England..
    Lambe, Sinead
    Warneford Hosp, Oxford Hlth NHS Fdn Trust, Oxford, England.;Univ Oxford, Dept Expt Psychol, Oxford, England..
    Ostinelli, Edoardo G.
    Univ Oxford, Dept Psychiat, Oxford, England.;Warneford Hosp, Oxford Hlth NHS Fdn Trust, Oxford, England.;NIHR Oxford Hlth Biomed Res Ctr, Oxford Precis Psychiat Lab, Oxford, England..
    Blease, Charlotte
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Participatory eHealth and Health Data Research Group.
    Gant, Thomas
    Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychol, London, England.;South London & Maudsley NHS Fdn Trust, London, England..
    Gold, Stefan M.
    Charite Univ Med Berlin, Dept Psychiat, Campus Benjamin Franklin, Berlin, Germany.;Charite Univ Med Berlin, Dept Psychosomat Med, Campus Benjamin Franklin, Berlin, Germany.;German Ctr Mental Hlth DZPG, Partner Site Berlin Potsdam, Berlin, Germany.;Univ Klinikum Hamburg Eppendorf, INIMS, Hamburg, Germany..
    Holmes, Emily A.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, PERCEPT – Mental Imagery and Mental Health.
    Paccoud, Ivana
    Univ Luxembourg, Luxembourg Ctr Syst Biomed LCSB, Esch Sur Alzette, Luxembourg..
    Vinnikova, Anastasia
    Klucken, Jochen
    Univ Luxembourg, Luxembourg Ctr Syst Biomed LCSB, Esch Sur Alzette, Luxembourg.;Ctr Hosp Luxembourg CHL, Luxembourg, Luxembourg..
    Uhlhaas, Peter J.
    Charite, Dept Child & Adolescent Psychiat, Psychosomat Med & Psychotherapy, Berlin, Germany..
    Garcia Sanchez, Carolina
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Participatory eHealth and Health Data Research Group.
    Haining, Kate
    Univ Glasgow, Sch Psychol & Neurosci, Glasgow, Scotland..
    Böge, Kerem
    Charite Univ Med Berlin, Dept Psychiat, Campus Benjamin Franklin, Berlin, Germany.;Charite Univ Med Berlin, Dept Psychosomat Med, Campus Benjamin Franklin, Berlin, Germany.;German Ctr Mental Hlth DZPG, Partner Site Berlin Potsdam, Berlin, Germany..
    Lahutina, Sofiia
    German Natl Acad Sci Leopoldina, Halle, Germany.;Charite Univ Med Berlin, Ctr Affekt Neurowissensch, Berlin, Germany..
    Tomelleri, Luisa
    Santa Giuliana Hosp, Verona, Italy..
    Ryan, Sean
    Harvard Med Sch, Beth Israel Deaconess Med Ctr, Div Digital Psychiat, Boston, MA USA..
    Torous, John
    Harvard Med Sch, Beth Israel Deaconess Med Ctr, Div Digital Psychiat, Boston, MA USA..
    Cipriani, Andrea
    Univ Oxford, Dept Psychiat, Oxford, England.;Warneford Hosp, Oxford Hlth NHS Fdn Trust, Oxford, England.;NIHR Oxford Hlth Biomed Res Ctr, Oxford Precis Psychiat Lab, Oxford, England..
    Engagement and attrition in digital mental health: current challenges and potential solutions2025In: npj Digital Medicine, E-ISSN 2398-6352, Vol. 8, article id 398Article in journal (Refereed)
    Abstract [en]

    In digital mental health engagement rates are consistently low, which may limit its effects. Using an international multidisciplinary consensus method, including lived experience expertise and a systematic review, we identified three key challenges: (i) lack of agreed metrics for engagement; (ii) lack of evidence on how better engagement improves outcomes; (iii) lack of standards for user involvement. Three potential solutions encompassed: (i) standardisation of frameworks for reporting engagement metrics and optimal doses of digital tools, (ii) measuring engagement with more precise reporting of outcomes, including potential harms; (iii) defining standards of user involvement (including appropriate diversity, and clinician as well as user input). Digital interventions have real potential in meeting the shortfall in service provision for mental health, but this will require focus on high quality research studies of the underlying mechanisms of engagement and optimal outcomes. Our findings identify and highlight the next best steps in this process.

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  • Yorulmaz, E. B.
    et al.
    Ankara Univ, Fac Sci, Astron & Space Sci Dept, TR-06100 Ankara, Turkiye.;Ankara Univ, Astron & Space Sci Res & Applicat Ctr, Kreiken Observ, Incek Blvd, TR-06837 Ankara, Turkiye..
    Ozavci, I.
    Ankara Univ, Fac Sci, Astron & Space Sci Dept, TR-06100 Ankara, Turkiye.;Ankara Univ, Astron & Space Sci Res & Applicat Ctr, Kreiken Observ, Incek Blvd, TR-06837 Ankara, Turkiye..
    Bahar, E.
    Ankara Univ, Fac Sci, Astron & Space Sci Dept, TR-06100 Ankara, Turkiye.;Ankara Univ, Astron & Space Sci Res & Applicat Ctr, Kreiken Observ, Incek Blvd, TR-06837 Ankara, Turkiye..
    Senavci, H. V.
    Ankara Univ, Fac Sci, Astron & Space Sci Dept, TR-06100 Ankara, Turkiye.;Ankara Univ, Astron & Space Sci Res & Applicat Ctr, Kreiken Observ, Incek Blvd, TR-06837 Ankara, Turkiye..
    Hussain, G. A. J.
    European Space Agcy ESA, European Space Res & Technol Ctr ESTEC, Keplerlaan 1, NL-2201 AZ Noordwijk, Netherlands..
    Kochukhov, Oleg
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Observational Astrophysics.
    Doppler imaging of the contact binary DU Boo2025In: CONTRIBUTIONS OF THE ASTRONOMICAL OBSERVATORY SKALNATE PLESO, ISSN 1335-1842, Vol. 55, no 3, p. 117-121Article in journal (Refereed)
    Abstract [en]

    The early-type contact binary DU Boo exhibits consistent O'Connell effect for many years. Studies in the literature of the system are insufficient to explain this consistency in the observed O'Connell effect. Based on this gap in the literature, the aim of this study is to investigate the surface brightness distribution of the system using the Doppler imaging technique as well as the mid-resolution time series spectra.

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  • Montarges, M.
    et al.
    CY Cergy Paris Univ, Univ Paris Cite, Sorbonne Univ, Univ PSL,LIRA,Observ Paris, F-92195 Meudon, France..
    Malfait, J.
    Katholieke Univ Leuven, Inst Astron, Celestijnenlaan 200D, B-3001 Leuven, Belgium..
    Esseldeurs, M.
    Katholieke Univ Leuven, Inst Astron, Celestijnenlaan 200D, B-3001 Leuven, Belgium..
    de Koter, A.
    Katholieke Univ Leuven, Inst Astron, Celestijnenlaan 200D, B-3001 Leuven, Belgium.;Univ Amsterdam, Anton Pannekoek Inst Astron, NL-1090 GE Amsterdam, Netherlands..
    Baron, F.
    Georgia State Univ, Ctr High Angular Resolut Astron, POB 5060, Atlanta, GA 30302 USA.;Georgia State Univ, Dept Phys & Astron, POB 5060, Atlanta, GA 30302 USA..
    Kervella, P.
    CY Cergy Paris Univ, Univ Paris Cite, Sorbonne Univ, Univ PSL,LIRA,Observ Paris, F-92195 Meudon, France..
    Danilovich, T.
    Katholieke Univ Leuven, Inst Astron, Celestijnenlaan 200D, B-3001 Leuven, Belgium.;Monash Univ, Sch Phys & Astron, Wellington Rd, Clayton, Vic 3800, Australia.;ARC Ctr Excellence All Sky Astrophys 3 Dimens ASTR, Clayton 3800, Australia..
    Richards, A. M. S.
    Univ Manchester, Jodrell Bank Ctr Astrophys, Dept Phys & Astron, Manchester M13 9PL, England..
    Sahai, R.
    CALTECH, Jet Prop Lab, Pasadena, CA 91109 USA..
    Mcdonald, I.
    Univ Manchester, Jodrell Bank Ctr Astrophys, Dept Phys & Astron, Manchester M13 9PL, England.;Open Univ, Walton Hall, Milton Keynes MK7 6AA, England..
    Khouri, T.
    Chalmers Univ Technol, Onsala Space Observ, S-43992 Onsala, Sweden..
    Shetye, S.
    Katholieke Univ Leuven, Inst Astron, Celestijnenlaan 200D, B-3001 Leuven, Belgium..
    Zijlstra, A.
    Univ Manchester, Jodrell Bank Ctr Astrophys, Dept Phys & Astron, Manchester M13 9PL, England.;Macquarie Univ, Sch Math & Phys Sci, Sydney, NSW, Australia..
    van de Sande, M.
    Leiden Univ, Leiden Observ, POB 9513, NL-2300 RA Leiden, Netherlands..
    El Mellah, I.
    Univ Santiago de Chile, Dept Fis, Ave Victor Jara 3659, Santiago, Chile.;USACH, Ctr Interdisciplinary Res Astrophys & Space Explor, Estn Cent, Chile..
    Herpin, F.
    Univ Bordeaux, Lab Astrophys Bordeaux, F-33615 Pessac, France..
    Siess, L.
    Univ Libre Bruxelles ULB, Inst Astron & Astrophys, CP 226, B-1060 Brussels, Belgium..
    Etoka, S.
    Univ Manchester, Jodrell Bank Ctr Astrophys, Dept Phys & Astron, Manchester M13 9PL, England..
    Gobrecht, D.
    Gothenburg Univ, Gothenburg, Sweden..
    Marinho, L.
    Univ Bordeaux, Lab Astrophys Bordeaux, F-33615 Pessac, France..
    Wallström, S. H. J.
    Wong, Ka Tat
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Theoretical Astrophysics.
    Yates, J.
    UCL, Dept Phys & Astron, London WC1E 6BT, England..
    An accreting dwarf star orbiting the S-type giant star π1 Gru2025In: Astronomy and Astrophysics, ISSN 0004-6361, E-ISSN 1432-0746, Vol. 699, article id A22Article in journal (Refereed)
    Abstract [en]

    Context: At the end of their lives, low- to intermediate-mass stars reach the asymptotic giant branch (AGB), during which their photospheres expand by up to several hundred times and strong stellar winds develop. These changes lead to various interactions with celestial bodies in their close circumstellar environments, including mass- and angular-momentum transfer.

    Aims: We aim to characterize the properties of the inner companion of the S-type AGB star π1 Gru and to identify plausible future evolutionary scenarios for this triple system.

    Methods: We observed π1 Gru with the Atacama Large Millimeter/sub-millimeter Array (ALMA) and the Spectro-Polarimetric High-contrast Exoplanet REsearch (SPHERE) instrument of the Very Large Telescope (VLT), collected archival photometric data, and used the HIPPARCOS-Gaia proper motion anomaly. We derived the best orbital parameters using Bayesian inference.

    Results: In June-July 2019, the inner companion, π1 Gru C, was located at 37.4±2.0 mas from the primary (a projected separation of 6.05±0.55 au at 161.7±11.7 pc). The best orbital solution yields a companion mass of 0.86+0.22-0.20 M (using the derived mass of the primary) and a semi-major axis of 7.05-0.57+0.54 au, corresponding to an orbital period of 11.0-1.5+1.7 yr. The preferred solution is an elliptical orbit with eccentricity e = 0.35-0.17+0.18, although a circular orbit cannot be fully excluded. The close companion could be either a K1VK7VF9.5V star or a white dwarf (WD). Ultraviolet and millimeter continuum photometry are consistent with the presence of an accretion disk around the close companion. The ultraviolet emission may originate from hot spots in an overall cooler disk, or from a hot disk if the companion is a WD.

    Conclusions: Although the close companion and the AGB star are interacting and an accretion disk is observed around the companion, the mass-accretion rate is too low to trigger a Type Ia supernova, but it could produce novae every ≈900 yr. Short-wavelength, spatially resolved observations are required to further constrain the nature of the C companion. Searches for close-in companions similar to this system will improve our understanding of the physics of mass and angular momentum transfer, as well as orbital evolution during late evolutionary stages.

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  • Arkkukangas, Marina
    et al.
    Dalarna University, School of Health and Welfare, Medical Science. Department of Physiotherapy, School of Health, Care and Social Welfare, Mälardalen University, Västerås; Centre for Clinical Research Sörmland, Uppsala University, Eskilstuna.
    Strömqvist Bååthe, Karin
    Department of Physiotherapy, School of Health, Care and Social Welfare, Mälardalen University, Västerås.
    Tonkonogi, Michail
    Department of Physiotherapy, School of Health, Care and Social Welfare, Mälardalen University, Västerås.
    Liljeroos, Maria
    Department of Physiotherapy, School of Health, Care and Social Welfare, Mälardalen University, Västerås; Department of Health, Medicine and Caring Sciences, Linköping University, Linköping.
    More Than Just Exercise: Older Adults' Experience of the Peer-Led Group-Based FallFitness Program2025In: Clinical Interventions in Aging, ISSN 1176-9092, E-ISSN 1178-1998, Vol. 20, p. 931-939Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Falls threaten the health and well-being of older adults. While studies have presented effective fall prevention exercises, determining how to deliver these interventions in a way that ensures engagement and long-term sustainability is challenging. Additionally, understanding how older adults perceive and are motivated to participate in such programs is critical for broad public health promotion. This study aimed to explore older adults' experiences and perceptions regarding participation in a newly developed 8-week peer-led group-based exercise program, FallFitness.

    METHODS: Participants were recruited from a randomized controlled trial (RCT) exploring a newly developed 8-week peer-led group-based exercise program. A total of 2 focus groups were conducted post intervention, comprising ten participants (8 women and 2 men) from the exercise arm of the RCT. Inductive and conventional qualitative content analysis was performed.

    RESULTS: From the interviews, 5 main categories and 6 subcategories capturing the study aim are presented. Main categories included: a) social interaction and community, more than just exercise, b) increased motivational drive and self-efficacy, c) group exercise as fun, safe, and inclusive activity, d) enhanced collaboration between healthcare providers and retirement organizations for fall prevention, and e) professional peer-led trainers.

    CONCLUSION: Peer-led, well-designed group-based exercise programs can holistically support physical, emotional, and social well-being. Programs that include enjoyable, multicomponent elements, both physically and mentally stimulating, can enhance participants' motivation and adherence. Additionally, the group setting is thought to promote meaningful social interaction, which is widely recognized as important for overall well-being. From a public health perspective, collaborative models for fall prevention involving older adults as a "golden resource" should be established.

    TRIAL REGISTRATION: ClinicalTrials.gov, NCT06265480 (2024-02-08).

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  • Ablikim, M.
    et al.
    Inst High Energy Phys, Beijing 100049, Peoples R China.
    Adlarson, Patrik
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Johansson, Tord
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Kupsc, Andrzej
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics. Natl Ctr Nucl Res, PL-02093 Warsaw, Poland.
    Schönning, Karin
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Wolke, Magnus
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Liu, Y.
    Lanzhou Univ, Lanzhou 730000, Peoples R China;Lanzhou Univ, Lanzhou Ctr Theoret Phys, Lanzhou 730000, Peoples R China;Lanzhou Univ, MOE Frontiers Sci Ctr Rare Isotopes, Lanzhou 730000, Peoples R China;Zhengzhou Univ, Zhengzhou 450001, Peoples R China.
    Measurement of the branching fractions of D+ →†’ K+K-π€+π+π-, φπ+π€+π€-, K0SK+π+π€- π0, K0SK+η, and K0SK+ω‰ decays2025In: Physical Review D: covering particles, fields, gravitation, and cosmology, ISSN 2470-0010, E-ISSN 2470-0029, Vol. 111, no 9, article id 092005Article in journal (Refereed)
    Abstract [en]

    Using 20.3 fb-1 of e+e- collision data collected at a center-of-mass energy of 3.773 GeV with the BESIII detector operating at the BEPCII collider, the branching fractions of three hadronic charm meson decays, D+φπ+π+π-, D+K0SK+π+π-π0, and D+K0S K+ω, are measured for the first time to be (0.54 ± 0.19 ± 0.02) x 10-4, (2.51 ± 0.34 ± 0.14) x 10-4, and (2.02 ± 0.35 ± 0.10) x 10-4, respectively. Futhermore, the branching fractions of D+K+K-π+π+π- and D+K0SK+η are measured with improved precision, yielding values of (0.66 ± 0.11 ± 0.03) x 10-4 and (2.27 ± 0.22 ± 0.05) x 10-4, respectively.

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  • Aronsson, Jennie
    et al.
    Faculty of Health, School of Nursing and Midwifery, University of Plymouth, Plymouth, Devon, UK., GB.
    Elf, Marie
    Dalarna University, School of Health and Welfare, Caring Science/Nursing.
    Warwick, Paul
    Plymouth Institute of Education, School of Society and Culture, University of Plymouth, Plymouth, Devon, UK., GB.
    Lo Martire, Riccardo
    Dalarna University, School of Health and Welfare, Medical Science. Centre for Clinical Research Dalarna, Uppsala University, Falun.
    Anåker, Anna
    Dalarna University, School of Health and Welfare, Caring Science/Nursing.
    The relevance of climate change and sustainability in nursing education: a cross-sectional study of students' perspectives2025In: BMC Nursing, E-ISSN 1472-6955, Vol. 24, no 1, article id 834Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: As climate change continues to challenge global health, nursing education must evolve to prepare future nurses for the impacts on care delivery and promote sustainable practices within the healthcare system which is itself a contributor to the climate crisis through emissions and waste. In this study we aimed to i) explore undergraduate nursing students' attitudes towards and awareness of climate change and sustainability issues and its inclusion in nursing education at a Swedish university, and ii) explore differences in awareness and attitudes across student groups in different semesters.

    METHODS: In this cross-sectional descriptive research study, nursing students from six groups (semester 1,2,3,4,5,6) of a three-year BSc Nursing programme were asked to complete the Sustainability Attitudes in Nursing Survey (SANS_2) questionnaire. Descriptive statistics were used to present mean scores for each item, and the Kruskal-Wallis test was used to identify differences in responses between different student groups. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement has been used to report this research.

    RESULTS: A total of 211 (32%) students completed the questionnaires. The findings showed that nursing students across the six semesters had relatively good awareness of, and positive attitudes towards, sustainability and climate change (no mean rating below 4 on a scale 1-7). Statistically significant differences between student groups were found in four out of nine items of the SANS_2 questionnaire, with students in their second semester consistently providing the highest ratings (p < 0.05). Notably, the lowest ratings across these four items were provided by students in their last year of the programme.

    CONCLUSIONS: This study found that whilst students initially felt equipped to address sustainability issues and climate change in practice, this confidence appears to diminish by the programme's end, raising concerns about the preparedness of the future workforce. This underscores the urgency and importance of continuous reinforcement of sustainability concepts in nursing education, aligning with a spiral curriculum approach which advocates for reiterating themes throughout the curriculum to deepen understanding.

    CLINICAL TRIAL NUMBER: Not applicable.

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  • de Vries, Laila
    et al.
    Dalarna University, School of Health and Welfare.
    Kylén, Maya
    Dalarna University, School of Health and Welfare, Caring Science/Nursing. Faculty of Health Science, Kristianstad University, Kristianstad.
    Svensson, Tony
    Dalarna University, School of Information and Engineering, Construction. Urban and Regional Studies, Royal Institute of Technology, KTH, Stockholm.
    Sturge, Jodi
    Department of Design, Production and Management, Faculty of Engineering Technology, University of Twente, Enschede, the Netherlands, NL.
    Lipson-Smith, Ruby
    The MARCS Institute for Brain, Behaviour and Development, Western Sydney University, Westmead, Australia, AU; The Florey Institute of Neuroscience and Mental Health, Parkville, Australia, AU.
    Schmidt, Steven M
    Department of Health Sciences, Faculty of Medicine, Lund University, Lund.
    Pessah-Rasmussen, Hélène
    Department of Neurology, Rehabilitation Medicine, Memory Disorders and Geriatrics, Skåne University Hospital, Malmö; Department of Clinical Sciences Lund, Lund University, Lund.
    Elf, Marie
    Dalarna University, School of Health and Welfare, Caring Science/Nursing.
    Stakeholder Perspectives on Built Environmental Factors to Support Stroke Rehabilitation and Return to Everyday Life2025In: Health Expectations, ISSN 1369-6513, E-ISSN 1369-7625, Vol. 28, no 4, article id e70339Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: The transition to undertaking rehabilitation in the home or local neighbourhood calls for an extensive understanding of which aspects of the built environment are important for people with stroke.

    OBJECTIVE: This qualitative study aims to explore how home and local neighbourhood environments support or hinder rehabilitation for people who have had a stroke from the perspectives of various stakeholders.

    METHODS: Through a purposive selection method, data were collected through semi-structured interviews with 16 stakeholders: people with stroke (n = 3), significant others (n = 3), healthcare professionals (n = 4), care managers (n = 3) and architects (n = 3). Content analysis was used to identify patterns and create themes.

    FINDINGS: Sixteen stakeholders, including 12 women and 4 men aged 30-74, participated in this study. Our findings identify areas linked to the WHO age-friendly environment framework, which addresses environmental limitations relevant to stroke rehabilitation. The categories used and factors identified: (1) Outdoor environments: accessibility, safety and supportiveness. (2) Transport and mobility: accessible and reach central services. (3) Housing: adaptations, layout and accessibility. (4) Social participation: spaces that are varied and flexible. (5) Social inclusion and non-discrimination: shared decision-making. (6) Civic engagement and employment: supporting environments. (7) Communication and information: digital accessibility. (8) Community and health services: patient-centred approach and access to varied rehabilitation.

    CONCLUSION: This study brings together multiple perspectives from key stakeholders with experience within stroke care. By integrating insights, these findings highlight how built environmental factors in the home and local neighbourhood can support the transition to home-based rehabilitation, which can improve recovery and return to everyday life. In turn, this study contributes to the innovative development of home and neighbourhood environments to influence and support stroke rehabilitation. Linking the findings to the WHO framework increases our understanding of a supportive environment for people with stroke, but also for people with other long-term conditions.

    PATIENT OR PUBLIC CONTRIBUTION: This qualitative study is part of a comprehensive research project '(Built Environments to support rehabilitation for people with stroke, B-SURE)', which aims to investigate how factors in the built environment influence stroke rehabilitation and to develop built environment solutions. B-SURE has a participatory methodology that essentially includes and involves the stakeholders in the multiple stages of the study and ensures an iterative and collaborative process.

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  • Aaij, R.
    et al.
    Nikhef Natl Inst Subatom Phys, Amsterdam, Netherlands.
    Adlarson, Patrik
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Eklund, Lars
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Kupsc, Andrzej
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Ruiz Vidal, Joan
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics. Department of Physics/Division of Particle Physics, Lund, Sweden.
    Xu, L.
    Monash Univ, Sch Phys & Astron, Melbourne, Australia;Tsinghua Univ, Dept Engn Phys, Beijing, Peoples R China.
    Search for resonance-enhanced CP and angular asymmetries in the Λ+c+μ- decay at LHCb2025In: Physical Review D: covering particles, fields, gravitation, and cosmology, ISSN 2470-0010, E-ISSN 2470-0029, Vol. 111, no 9, article id L091102Article in journal (Refereed)
    Abstract [en]

    The first measurement of the CP asymmetry of the decay rate (ACP) and the CP average (ΣAFB) and CP asymmetry (ΔAFB) of the forward-backward asymmetry in the muon system of Λ+c+μ- decays is reported. The measurement is performed using a data sample of proton-proton collisions, recorded by the LHCb experiment from 2016 to 2018 at a center-of-mass energy of 13 TeV, which corresponds to an integrated luminosity of 5.4 fb-1. The asymmetries are measured in two regions of dimuon mass near the φ-meson mass peak. The dimuon-mass integrated results are ACP = (-1.1 ± 4.0 ± 0.5)%, ΣAFB = (3.9 ± 4.0 ± 0.6)%, ΔAFB = (3.1 ± 4.0 ± 0.4)%, where the first uncertainty is statistical and the second systematic. The results are consistent with the conservation of CP symmetry and the Standard Model expectations.

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  • Koyama, K.
    et al.
    Univ Portsmouth, Inst Cosmol & Gravitat, Portsmouth PO1 3FX, Hants, England..
    Pamuk, S.
    Rhein Westfal TH Aachen, Inst Theoret Particle Phys & Cosmol TTK, D-52056 Aachen, Germany..
    Casas, S.
    Rhein Westfal TH Aachen, Inst Theoret Particle Phys & Cosmol TTK, D-52056 Aachen, Germany..
    Bose, B.
    Univ Edinburgh, Inst Astron, Royal Observ, Blackford Hill, Edinburgh EH9 3HJ, Scotland..
    Carrilho, P.
    Univ Edinburgh, Inst Astron, Royal Observ, Blackford Hill, Edinburgh EH9 3HJ, Scotland..
    Saez-Casares, I.
    Univ Paris, Univ PSL, Observ Paris, Lab Univers & Theories,CNRS, F-92190 Meudon, France..
    Atayde, L.
    Univ Lisbon, Fac Ciencias, Inst Astrofis & Ciencias Espaco, P-1749016 Campo Grande, Lisboa, Portugal.;Univ Lisbon, Dept Fis, Fac Ciencias, Edificio C8, PT-1749016 Lisbon, Portugal..
    Cataneo, M.
    Ruhr Univ Bochum, Astron Inst AIRUB, Fac Phys & Astron, German Ctr Cosmol Lensing GCCL, D-44780 Bochum, Germany.;Univ Bonn, Argelander Inst Astron, Hugel 71, D-53121 Bonn, Germany..
    Fiorini, B.
    Univ Portsmouth, Inst Cosmol & Gravitat, Portsmouth PO1 3FX, Hants, England..
    Giocoli, C.
    INAF, Osservatorio Astrofis & Sci Spazio Bologna, via Piero Gobetti 93-3, I-40129 Bologna, Italy.;Ist Nazl Fis Nucl, Sez Bologna, Via Irnerio 46, I-40126 Bologna, Italy..
    Le Brun, A. M. C.
    Univ Paris, Univ PSL, Observ Paris, Lab Univers & Theories,CNRS, F-92190 Meudon, France..
    Pace, F.
    Univ Torino, Dipartimento Fis, Via P Giuria 1, I-10125 Turin, Italy.;INFN, Sez Torino, Via P Giuria 1, I-10125 Turin, Italy.;INAF, Osservatorio Astrofis Torino, Via Osservatorio 20, I-10025 Pino Torinese, TO, Italy..
    Pourtsidou, A.
    Univ Edinburgh, Inst Astron, Royal Observ, Blackford Hill, Edinburgh EH9 3HJ, Scotland.;Univ Edinburgh, Sch Phys & Astron, Higgs Ctr Theoret Phys, Edinburgh EH9 3FD, Midlothian, Scotland..
    Rasera, Y.
    Univ Paris, Univ PSL, Observ Paris, Lab Univers & Theories,CNRS, F-92190 Meudon, France.;Inst Univ France IUF, 1 Rue Descartes, F-75231 Paris 05, France..
    Sakr, Z.
    Heidelberg Univ, Inst Theoret Phys, Philosophenweg 16, D-69120 Heidelberg, Germany.;Univ Toulouse, Inst Rech Astrophys & Planetol, CNRS, UPS,CNES, 14 Ave Edouard Belin, F-31400 Toulouse, France.;Univ St Joseph, Fac Sci, Beirut, Lebanon..
    Winther, H. -A
    Altamura, E.
    Univ Manchester, Dept Phys & Astron, Jodrell Bank Ctr Astrophys, Oxford Rd, Manchester M13 9PL, Lancs, England..
    Adamek, J.
    Univ Zurich, Dept Astrophys, Winterthurerstr 190, CH-8057 Zurich, Switzerland..
    Baldi, M.
    INAF, Osservatorio Astrofis & Sci Spazio Bologna, via Piero Gobetti 93-3, I-40129 Bologna, Italy.;Univ Bologna, Dipartimento Fis Astron, Via Gobetti 93-2, I-40129 Bologna, Italy.;INFN, Sez Bologna, Viale Berti Pichat 6-2, I-40127 Bologna, Italy..
    Breton, M. -A
    Racz, G.
    CALTECH, Jet Prop Lab, 4800 Oak Grove Dr, Pasadena, CA 91109 USA..
    Vernizzi, F.
    Univ Paris Saclay, Inst Phys Theor, CEA, CNRS, F-91191 Gif Sur Yvette, France..
    Amara, A.
    Univ Surrey, Sch Math & Phys, Guildford GU2 7XH, Surrey, England..
    Andreon, S.
    INAF, Osservatorio Astron Brera, Via Brera 28, I-20122 Milan, Italy..
    Auricchio, N.
    INAF, Osservatorio Astrofis & Sci Spazio Bologna, via Piero Gobetti 93-3, I-40129 Bologna, Italy..
    Baccigalupi, C.
    Inst Fundamental Phys Universe, Via Beirut 2, I-34151 Trieste, Italy.;INAF, Osservatorio Astron Trieste, Via GB Tiepolo 11, I-34143 Trieste, Italy.;INFN, Sez Trieste, Via Valerio 2, I-34127 Trieste, TS, Italy.;SISSA, Int Sch Adv Studies, Via Bonomea 265, I-34136 Trieste, TS, Italy..
    Bardelli, S.
    INAF, Osservatorio Astrofis & Sci Spazio Bologna, via Piero Gobetti 93-3, I-40129 Bologna, Italy..
    Bernardeau, F.
    Univ Paris Saclay, Inst Phys Theor, CEA, CNRS, F-91191 Gif Sur Yvette, France.;CNRS, Inst Astrophys Paris, UMR 7095, 98 Bis Blvd Arago, F-75014 Paris, France.;Sorbonne Univ, 98 Bis Blvd Arago, F-75014 Paris, France..
    Biviano, A.
    Inst Fundamental Phys Universe, Via Beirut 2, I-34151 Trieste, Italy.;INAF, Osservatorio Astron Trieste, Via GB Tiepolo 11, I-34143 Trieste, Italy..
    Bodendorf, C.
    Max Planck Inst Extraterr Phys, Giessenbachstr 1, D-85748 Garching, Germany..
    Bonino, D.
    INAF, Osservatorio Astrofis Torino, Via Osservatorio 20, I-10025 Pino Torinese, TO, Italy..
    Branchini, E.
    INAF, Osservatorio Astron Brera, Via Brera 28, I-20122 Milan, Italy.;Univ Genoa, Dipartimento Fis, Via Dodecaneso 33, I-16146 Genoa, Italy.;INFN, Sez Genova, Via Dodecaneso 33, I-16146 Genoa, Italy..
    Brescia, M.
    Univ Federico II, Dept Phys Pancini, Via Cinthia 6, I-80126 Naples, Italy.;INAF, Osservatorio Astron Capodimonte, Via Moiariello 16, I-80131 Naples, Italy.;INFN, Sect Naples, Via Cinthia 6, I-80126 Naples, Italy..
    Brinchmann, J.
    Univ Porto, Inst Astrofis & Ciencias Espaco, CAUP, Rua Estrelas, PT-4150762 Porto, Portugal.;Univ Porto, Fac Ciencias, Rua Campo Alegre, P-4150007 Porto, Portugal..
    Caillat, A.
    Aix Marseille Univ, CNRS, CNES, LAM, Marseille, France..
    Camera, S.
    Univ Torino, Dipartimento Fis, Via P Giuria 1, I-10125 Turin, Italy.;INFN, Sez Torino, Via P Giuria 1, I-10125 Turin, Italy.;INAF, Osservatorio Astrofis Torino, Via Osservatorio 20, I-10025 Pino Torinese, TO, Italy..
    Canas-Herrera, G.
    European Space Agcy ESTEC, Keplerlaan 1, NL-2201 AZ Noordwijk, Netherlands.;Leiden Univ, Inst Lorentz, Niels Bohrweg 2, NL-2333 CA Leiden, Netherlands..
    Capobianco, V.
    INAF, Osservatorio Astrofis Torino, Via Osservatorio 20, I-10025 Pino Torinese, TO, Italy..
    Carbone, C.
    INAF IASF Milano, Via Alfonso Corti 12, I-20133 Milan, Italy..
    Carretero, J.
    CIEMAT, Ave Complutense 40, Madrid 28040, Spain.;Port Informacio Cient, Campus UAB,C Albareda S-N, Bellaterra 08193, Barcelona, Spain..
    Castellano, M.
    INAF, Osservatorio Astron Roma, Via Frascati 33, I-00078 Monte Porzio Catone, Italy..
    Castignani, G.
    INAF, Osservatorio Astrofis & Sci Spazio Bologna, via Piero Gobetti 93-3, I-40129 Bologna, Italy..
    Cavuoti, S.
    INAF, Osservatorio Astron Capodimonte, Via Moiariello 16, I-80131 Naples, Italy.;INFN, Sect Naples, Via Cinthia 6, I-80126 Naples, Italy..
    Chambers, K. C.
    Univ Hawaii, Inst Astron, 2680 Woodlawn Dr, Honolulu, HI 96822 USA..
    Cimatti, A.
    Alma Mater Studiorum Univ Bologna, Dipartimento Fis & Astron Augusto Righi, Viale Berti Pichat 6-2, I-40127 Bologna, Italy..
    Colodro-Conde, C.
    Inst Astrofis Canarias, Via Lactea, San Cristobal la Laguna 38205, Spain..
    Congedo, G.
    Univ Edinburgh, Inst Astron, Royal Observ, Blackford Hill, Edinburgh EH9 3HJ, Scotland..
    Conselice, C. J.
    Univ Manchester, Dept Phys & Astron, Jodrell Bank Ctr Astrophys, Oxford Rd, Manchester M13 9PL, Lancs, England..
    Conversi, L.
    European Space Agcy ESRIN, Largo Galileo Galilei 1, I-00044 Rome, Italy.;ESA, ESAC, Camino Bajo Castillo S-N, Madrid 28692, Spain..
    Copin, Y.
    Univ Claude Bernard Lyon 1, CNRS, IN2P3, IP2I Lyon,UMR 5822, F-69100 Villeurbanne, France..
    Courbin, F.
    Ecole Polytech Fed Lausanne, Inst Phys, Astrophys Lab, Observ Sauverny, CH-1290 Versoix, Switzerland.;Univ Barcelona, IEEC, Inst Ciencies Cosmos, Marti i Franques 1, Barcelona 08028, Spain.;Inst Catalana Recerca & Estudis Avancats, Passeig Lluis Companys 23, Barcelona 08010, Spain..
    Courtois, H. M.
    UCB Lyon 1, CNRS, IN2P3, IUF,IP2I Lyon, 4 Rue Enrico Fermi, F-69622 Villeurbanne, France..
    Da Silva, A.
    Univ Lisbon, Fac Ciencias, Inst Astrofis & Ciencias Espaco, P-1749016 Campo Grande, Lisboa, Portugal.;Univ Lisbon, Dept Fis, Fac Ciencias, Edificio C8, PT-1749016 Lisbon, Portugal..
    Degaudenzi, H.
    Univ Geneva, Dept Astron, Ch Ecogia 16, CH-1290 Versoix, Switzerland..
    De Lucia, G.
    INAF, Osservatorio Astron Trieste, Via GB Tiepolo 11, I-34143 Trieste, Italy..
    Dole, H.
    Univ Paris Saclay, CNRS, Inst Astrophys Spatiale, F-91405 Orsay, France..
    Douspis, M.
    Univ Paris Saclay, CNRS, Inst Astrophys Spatiale, F-91405 Orsay, France..
    Dubath, F.
    Univ Geneva, Dept Astron, Ch Ecogia 16, CH-1290 Versoix, Switzerland..
    Duncan, C. A. J.
    Univ Manchester, Dept Phys & Astron, Jodrell Bank Ctr Astrophys, Oxford Rd, Manchester M13 9PL, Lancs, England..
    Dupac, X.
    ESA, ESAC, Camino Bajo Castillo S-N, Madrid 28692, Spain..
    Dusini, S.
    INFN Padova, Via Marzolo 8, I-35131 Padua, Italy..
    Escoffier, S.
    Aix Marseille Univ, CNRS, IN2P3, CPPM, Marseille, France..
    Farina, M.
    INAF Ist Astrofis & Planetol Spaziali, Via Fosso Cavaliere 100, I-00100 Rome, Italy..
    Farinelli, R.
    INAF, Osservatorio Astrofis & Sci Spazio Bologna, via Piero Gobetti 93-3, I-40129 Bologna, Italy..
    Farrens, S.
    Univ Paris Saclay, Univ Paris Cite, CEA, CNRS,AIM, F-91191 Gif Sur Yvette, France..
    Ferriol, S.
    Univ Claude Bernard Lyon 1, CNRS, IN2P3, IP2I Lyon,UMR 5822, F-69100 Villeurbanne, France..
    Finelli, F.
    INAF, Osservatorio Astrofis & Sci Spazio Bologna, via Piero Gobetti 93-3, I-40129 Bologna, Italy.;INFN Bologna, Via Irnerio 46, I-40126 Bologna, Italy..
    Fosalba, P.
    CSIC, Inst Space Sci ICE, Campus UAB,Carrer Can Magrans S-N, Barcelona 08193, Spain.;Inst Estudis Espacials Catalunya IEEC, Edifici RDIT,Campus UPC, Barcelona 08860, Spain..
    Frailis, M.
    INAF, Osservatorio Astron Trieste, Via GB Tiepolo 11, I-34143 Trieste, Italy..
    Franceschi, E.
    INAF, Osservatorio Astrofis & Sci Spazio Bologna, via Piero Gobetti 93-3, I-40129 Bologna, Italy..
    Galeotta, S.
    INAF, Osservatorio Astron Trieste, Via GB Tiepolo 11, I-34143 Trieste, Italy..
    Gillis, B.
    Univ Edinburgh, Inst Astron, Royal Observ, Blackford Hill, Edinburgh EH9 3HJ, Scotland..
    Gomez-Alvarez, P.
    ESA, ESAC, Camino Bajo Castillo S-N, Madrid 28692, Spain.;FRACTAL SLNE, Calle Tulipan 2,Portal 13 1A, Las Rozas De Madrid 28231, Spain..
    Gracia-Carpio, J.
    Max Planck Inst Extraterr Phys, Giessenbachstr 1, D-85748 Garching, Germany..
    Grazian, A.
    INAF Osservatorio Astron Padova, Via Osservatorio 5, I-35122 Padua, Italy..
    Grupp, F.
    Max Planck Inst Extraterr Phys, Giessenbachstr 1, D-85748 Garching, Germany.;Ludwig Maximilians Univ Munchen, Fak Phys, Univ Sternwarte Munchen, Scheinerstr 1, D-81679 Munich, Germany..
    Guzzo, L.
    INAF, Osservatorio Astron Brera, Via Brera 28, I-20122 Milan, Italy.;Univ Milan, Dipartimento Fis Aldo Pontremoli, Via Celoria 16, I-20133 Milan, Italy..
    Hailey, M.
    Univ Coll London, Mullard Space Sci Lab, Holmbury St Mary, Dorking RH5 6NT, Surrey, England..
    Haugan, S. V. H.
    Univ Oslo, Inst Theoret Astrophys, POB 1029, N-0315 Oslo, Norway..
    Holmes, W.
    CALTECH, Jet Prop Lab, 4800 Oak Grove Dr, Pasadena, CA 91109 USA..
    Hormuth, F.
    Felix Hormuth Engn, Goethestr 17, D-69181 Leimen, Germany..
    Hornstrup, A.
    Tech Univ Denmark, Elektrovej 327, DK-2800 Lyngby, Denmark.;Cosm Dawn Ctr DAWN, Copenhagen, Denmark..
    Hudelot, P.
    CNRS, Inst Astrophys Paris, UMR 7095, 98 Bis Blvd Arago, F-75014 Paris, France.;Sorbonne Univ, 98 Bis Blvd Arago, F-75014 Paris, France..
    Ilic, S.
    Univ Toulouse, Inst Rech Astrophys & Planetol, CNRS, UPS,CNES, 14 Ave Edouard Belin, F-31400 Toulouse, France.;Univ Paris Saclay, IJCLab, CNRS, IN2P3, F-91405 Orsay, France..
    Jahnke, K.
    Max Planck Inst Astron, Konigstuhl 17, D-69117 Heidelberg, Germany..
    Jhabvala, M.
    NASA, Goddard Space Flight Ctr, Greenbelt, MD 20771 USA..
    Joachimi, B.
    UCL, Dept Phys & Astron, Gower St, London WC1E 6BT, England..
    Keihanen, E.
    Univ Helsinki, Dept Phys, Gustaf Hallstromin Katu 2, Helsinki 00014, Finland.;Univ Helsinki, Helsinki Inst Phys, Gustaf Hallstromin Katu 2, Helsinki 00014, Finland..
    Kermiche, S.
    Aix Marseille Univ, CNRS, IN2P3, CPPM, Marseille, France..
    Kiessling, A.
    CALTECH, Jet Prop Lab, 4800 Oak Grove Dr, Pasadena, CA 91109 USA..
    Kilbinger, M.
    Univ Paris Saclay, Univ Paris Cite, CEA, CNRS,AIM, F-91191 Gif Sur Yvette, France..
    Kubik, B.
    Univ Claude Bernard Lyon 1, CNRS, IN2P3, IP2I Lyon,UMR 5822, F-69100 Villeurbanne, France..
    Kunz, M.
    Univ Geneva, Dept Phys Theor, 24 Quai Ernest Ansermet, CH-1211 Geneva 4, Switzerland.;Univ Geneva, Ctr Astroparticle Phys, 24 Quai Ernest Ansermet, CH-1211 Geneva 4, Switzerland..
    Kurki-Suonio, H.
    Univ Helsinki, Helsinki Inst Phys, Gustaf Hallstromin Katu 2, Helsinki 00014, Finland.;Univ Helsinki, Dept Phys, POB 64, Helsinki 00014, Finland..
    Lilje, P. B.
    Univ Oslo, Inst Theoret Astrophys, POB 1029, N-0315 Oslo, Norway..
    Lindholm, V.
    Univ Helsinki, Helsinki Inst Phys, Gustaf Hallstromin Katu 2, Helsinki 00014, Finland.;Univ Helsinki, Dept Phys, POB 64, Helsinki 00014, Finland..
    Lloro, I.
    ASTRON, NOVA Opt Infrared Instrumentat Grp, Oude Hoogeveensedijk 4, NL-7991 PD Dwingeloo, Netherlands..
    Mainetti, G.
    CNRS, IN2P3, Ctr Calcul, 21 Ave Pierre Coubertin, F-69627 Villeurbanne, France..
    Maino, D.
    INAF IASF Milano, Via Alfonso Corti 12, I-20133 Milan, Italy.;Univ Milan, Dipartimento Fis Aldo Pontremoli, Via Celoria 16, I-20133 Milan, Italy.;INFN, Sez Milano, Via Celoria 16, I-20133 Milan, Italy..
    Maiorano, E.
    INAF, Osservatorio Astrofis & Sci Spazio Bologna, via Piero Gobetti 93-3, I-40129 Bologna, Italy..
    Mansutti, O.
    INAF, Osservatorio Astron Trieste, Via GB Tiepolo 11, I-34143 Trieste, Italy..
    Marggraf, O.
    Univ Bonn, Argelander Inst Astron, Hugel 71, D-53121 Bonn, Germany..
    Markovic, K.
    CALTECH, Jet Prop Lab, 4800 Oak Grove Dr, Pasadena, CA 91109 USA..
    Martinelli, M.
    INAF, Osservatorio Astron Roma, Via Frascati 33, I-00078 Monte Porzio Catone, Italy.;INFN, Sez Roma, Dipartimento Fis, Piazzale Aldo Moro 2,Edificio G Marconi, I-00185 Rome, Italy..
    Martinet, N.
    Aix Marseille Univ, CNRS, CNES, LAM, Marseille, France..
    Marulli, F.
    INAF, Osservatorio Astrofis & Sci Spazio Bologna, via Piero Gobetti 93-3, I-40129 Bologna, Italy.;INFN, Sez Bologna, Viale Berti Pichat 6-2, I-40127 Bologna, Italy.;Alma Mater Studiorum Univ Bologna, Dipartimento Fis & Astron Augusto Righi, Via Piero Gobetti 93-2, I-40129 Bologna, Italy..
    Massey, R.
    Univ Durham, Inst Computat Cosmol, Dept Phys, South Rd, Durham DH1 3LE, England..
    Medinaceli, E.
    INAF, Osservatorio Astrofis & Sci Spazio Bologna, via Piero Gobetti 93-3, I-40129 Bologna, Italy..
    Mei, S.
    Univ Paris Cite, CNRS, Astroparticule & Cosmol, F-75013 Paris, France..
    Melchior, M.
    Univ Appl Sci & Arts Northwestern Switzerland, Sch Engn, CH-5210 Windisch, Switzerland..
    Mellier, Y.
    CNRS, Inst Astrophys Paris, UMR 7095, 98 Bis Blvd Arago, F-75014 Paris, France.;Sorbonne Univ, 98 Bis Blvd Arago, F-75014 Paris, France.;Inst Astrophys Paris, 98bis Blvd Arago, F-75014 Paris, France..
    Meneghetti, M.
    INAF, Osservatorio Astrofis & Sci Spazio Bologna, via Piero Gobetti 93-3, I-40129 Bologna, Italy.;INFN, Sez Bologna, Viale Berti Pichat 6-2, I-40127 Bologna, Italy..
    Merlin, E.
    INAF, Osservatorio Astron Roma, Via Frascati 33, I-00078 Monte Porzio Catone, Italy..
    Meylan, G.
    Ecole Polytech Fed Lausanne, Inst Phys, Astrophys Lab, Observ Sauverny, CH-1290 Versoix, Switzerland..
    Mora, A.
    Aurora Technol European Space Agcy ESA, Camino Bajo Castillo S-N, Madrid 28692, Spain..
    Moresco, M.
    INAF, Osservatorio Astrofis & Sci Spazio Bologna, via Piero Gobetti 93-3, I-40129 Bologna, Italy.;Alma Mater Studiorum Univ Bologna, Dipartimento Fis & Astron Augusto Righi, Via Piero Gobetti 93-2, I-40129 Bologna, Italy..
    Moscardini, L.
    INAF, Osservatorio Astrofis & Sci Spazio Bologna, via Piero Gobetti 93-3, I-40129 Bologna, Italy.;INFN, Sez Bologna, Viale Berti Pichat 6-2, I-40127 Bologna, Italy.;Alma Mater Studiorum Univ Bologna, Dipartimento Fis & Astron Augusto Righi, Via Piero Gobetti 93-2, I-40129 Bologna, Italy..
    Munari, E.
    Inst Fundamental Phys Universe, Via Beirut 2, I-34151 Trieste, Italy.;INAF, Osservatorio Astron Trieste, Via GB Tiepolo 11, I-34143 Trieste, Italy..
    Neissner, C.
    Port Informacio Cient, Campus UAB,C Albareda S-N, Bellaterra 08193, Barcelona, Spain.;Barcelona Inst Sci & Technol, IFAE, Campus UAB, Bellaterra 08193, Barcelona, Spain..
    Niemi, S. -M
    Padilla, C.
    Barcelona Inst Sci & Technol, IFAE, Campus UAB, Bellaterra 08193, Barcelona, Spain..
    Paltani, S.
    Univ Geneva, Dept Astron, Ch Ecogia 16, CH-1290 Versoix, Switzerland..
    Pasian, F.
    INAF, Osservatorio Astron Trieste, Via GB Tiepolo 11, I-34143 Trieste, Italy..
    Pedersen, K.
    Univ Copenhagen, Niels Bohr Inst, DARK, Jagtvej 155, DK-2200 Copenhagen, Denmark..
    Percival, W. J.
    Univ Waterloo, Waterloo Ctr Astrophys, Waterloo, ON N2L 3G1, Canada.;Univ Waterloo, Dept Phys & Astron, Waterloo, ON N2L 3G1, Canada.;Perimeter Inst Theoret Phys, Waterloo, ON N2L 2Y5, Canada..
    Pettorino, V.
    European Space Agcy ESTEC, Keplerlaan 1, NL-2201 AZ Noordwijk, Netherlands..
    Pires, S.
    Univ Paris Saclay, Univ Paris Cite, CEA, CNRS,AIM, F-91191 Gif Sur Yvette, France..
    Polenta, G.
    Italian Space Agcy, Space Sci Data Ctr, Via Politecn Snc, I-00133 Rome, Italy..
    Poncet, M.
    Ctr Natl Etud Spatiales, Ctr Spatial Toulouse, 18 Ave Edouard Belin, F-31401 Toulouse 9, France..
    Popa, L. A.
    Inst Space Sci, Str Atomistilor 409, Ilfov 077125, Romania..
    Pozzetti, L.
    INAF, Osservatorio Astrofis & Sci Spazio Bologna, via Piero Gobetti 93-3, I-40129 Bologna, Italy..
    Raison, F.
    Max Planck Inst Extraterr Phys, Giessenbachstr 1, D-85748 Garching, Germany..
    Renzi, A.
    INFN Padova, Via Marzolo 8, I-35131 Padua, Italy.;Univ Padua, Dipartimento Fis & Astron G Galilei, Via Marzolo 8, I-35131 Padua, Italy..
    Rhodes, J.
    CALTECH, Jet Prop Lab, 4800 Oak Grove Dr, Pasadena, CA 91109 USA..
    Riccio, G.
    INAF, Osservatorio Astron Capodimonte, Via Moiariello 16, I-80131 Naples, Italy..
    Romelli, E.
    INAF, Osservatorio Astron Trieste, Via GB Tiepolo 11, I-34143 Trieste, Italy..
    Roncarelli, M.
    INAF, Osservatorio Astrofis & Sci Spazio Bologna, via Piero Gobetti 93-3, I-40129 Bologna, Italy..
    Saglia, R.
    Max Planck Inst Extraterr Phys, Giessenbachstr 1, D-85748 Garching, Germany.;Ludwig Maximilians Univ Munchen, Fak Phys, Univ Sternwarte Munchen, Scheinerstr 1, D-81679 Munich, Germany..
    Salvignol, J. -C
    Sanchez, A. G.
    Max Planck Inst Extraterr Phys, Giessenbachstr 1, D-85748 Garching, Germany..
    Sapone, D.
    Univ Chile, Dept Fis, FCFM, Santiago 2008, Chile..
    Sartoris, B.
    INAF, Osservatorio Astron Trieste, Via GB Tiepolo 11, I-34143 Trieste, Italy.;Ludwig Maximilians Univ Munchen, Fak Phys, Univ Sternwarte Munchen, Scheinerstr 1, D-81679 Munich, Germany..
    Schirmer, M.
    Max Planck Inst Astron, Konigstuhl 17, D-69117 Heidelberg, Germany..
    Schrabback, T.
    Univ Innsbruck, Inst Astro & Teilchenphys, Technikerstr 25-8, A-6020 Innsbruck, Austria..
    Secroun, A.
    Aix Marseille Univ, CNRS, IN2P3, CPPM, Marseille, France..
    Seidel, G.
    Max Planck Inst Astron, Konigstuhl 17, D-69117 Heidelberg, Germany..
    Serrano, S.
    CSIC, Inst Space Sci ICE, Campus UAB,Carrer Can Magrans S-N, Barcelona 08193, Spain.;Inst Estudis Espacials Catalunya IEEC, Edifici RDIT,Campus UPC, Barcelona 08860, Spain.;Satlantis, Univ Sci Pk,Sede Bld, Leioa 48940, Spain..
    Sirignano, C.
    INFN Padova, Via Marzolo 8, I-35131 Padua, Italy.;Univ Padua, Dipartimento Fis & Astron G Galilei, Via Marzolo 8, I-35131 Padua, Italy..
    Sirri, G.
    INFN, Sez Bologna, Viale Berti Pichat 6-2, I-40127 Bologna, Italy..
    Spurio Mancini, A.
    Univ Coll London, Mullard Space Sci Lab, Holmbury St Mary, Dorking RH5 6NT, Surrey, England.;Royal Holloway Univ London, Dept Phys, London TW20 0EX, England..
    Stanco, L.
    INFN Padova, Via Marzolo 8, I-35131 Padua, Italy..
    Steinwagner, J.
    Max Planck Inst Extraterr Phys, Giessenbachstr 1, D-85748 Garching, Germany..
    Tallada-Crespi, P.
    CIEMAT, Ave Complutense 40, Madrid 28040, Spain.;Port Informacio Cient, Campus UAB,C Albareda S-N, Bellaterra 08193, Barcelona, Spain..
    Taylor, A. N.
    Univ Edinburgh, Inst Astron, Royal Observ, Blackford Hill, Edinburgh EH9 3HJ, Scotland..
    Tereno, I.
    Univ Lisbon, Dept Fis, Fac Ciencias, Edificio C8, PT-1749016 Lisbon, Portugal.;Univ Lisbon, Fac Ciencias, Inst Astrofis & Ciencias Espaco, P-1349018 Lisbon, Portugal..
    Tessore, N.
    UCL, Dept Phys & Astron, Gower St, London WC1E 6BT, England..
    Toft, S.
    Cosm Dawn Ctr DAWN, Copenhagen, Denmark.;Univ Copenhagen, Niels Bohr Inst, Jagtvej 128, DK-2200 Copenhagen, Denmark..
    Toledo-Moreo, R.
    Univ Politecn Cartagena, Dept Elect & Tecnol Comp, Plaza Hosp 1, Cartagena 30202, Spain..
    Torradeflot, F.
    CIEMAT, Ave Complutense 40, Madrid 28040, Spain.;Port Informacio Cient, Campus UAB,C Albareda S-N, Bellaterra 08193, Barcelona, Spain..
    Tutusaus, I.
    Univ Toulouse, Inst Rech Astrophys & Planetol, CNRS, UPS,CNES, 14 Ave Edouard Belin, F-31400 Toulouse, France..
    Valenziano, L.
    INAF, Osservatorio Astrofis & Sci Spazio Bologna, via Piero Gobetti 93-3, I-40129 Bologna, Italy.;INFN Bologna, Via Irnerio 46, I-40126 Bologna, Italy..
    Valiviita, J.
    Univ Helsinki, Helsinki Inst Phys, Gustaf Hallstromin Katu 2, Helsinki 00014, Finland.;Univ Helsinki, Dept Phys, POB 64, Helsinki 00014, Finland..
    Vassallo, T.
    INAF, Osservatorio Astron Trieste, Via GB Tiepolo 11, I-34143 Trieste, Italy.;Ludwig Maximilians Univ Munchen, Fak Phys, Univ Sternwarte Munchen, Scheinerstr 1, D-81679 Munich, Germany..
    Verdoes Kleijn, G.
    Univ Groningen, Kapteyn Astron Inst, POB 800, NL-9700 AV Groningen, Netherlands..
    Veropalumbo, A.
    INAF, Osservatorio Astron Brera, Via Brera 28, I-20122 Milan, Italy.;INFN, Sez Genova, Via Dodecaneso 33, I-16146 Genoa, Italy.;Univ Genoa, Dipartimento Fis, Via Dodecaneso 33, I-16146 Genoa, Italy.;INFN, Sez Genova, Via Dodecaneso 33, I-16146 Genoa, Italy..
    Wang, Y.
    CALTECH, Infrared Proc & Anal Ctr, Pasadena, CA 91125 USA..
    Weller, J.
    Max Planck Inst Extraterr Phys, Giessenbachstr 1, D-85748 Garching, Germany.;Ludwig Maximilians Univ Munchen, Fak Phys, Univ Sternwarte Munchen, Scheinerstr 1, D-81679 Munich, Germany..
    Zamorani, G.
    INAF, Osservatorio Astrofis & Sci Spazio Bologna, via Piero Gobetti 93-3, I-40129 Bologna, Italy..
    Zucca, E.
    INAF, Osservatorio Astrofis & Sci Spazio Bologna, via Piero Gobetti 93-3, I-40129 Bologna, Italy..
    Bozzo, E.
    Univ Geneva, Dept Astron, Ch Ecogia 16, CH-1290 Versoix, Switzerland..
    Burigana, C.
    INFN Bologna, Via Irnerio 46, I-40126 Bologna, Italy.;INAF, Ist Radioastron, Via Piero Gobetti 101, I-40129 Bologna, Italy..
    Calabrese, M.
    INAF IASF Milano, Via Alfonso Corti 12, I-20133 Milan, Italy.;Astron Observ Autonomous Reg Aosta Valley OAVd, Loc Lignan 39, I-11020 Nus, Aosta Valley, Italy..
    Di Ferdinando, D.
    INFN, Sez Bologna, Viale Berti Pichat 6-2, I-40127 Bologna, Italy..
    Escartin Vigo, J. A.
    Max Planck Inst Extraterr Phys, Giessenbachstr 1, D-85748 Garching, Germany..
    Fabbian, G.
    Univ Cambridge, Inst Astron, Madingley Rd, Cambridge CB3 0HA, England.;Cardiff Univ, Sch Phys & Astron, Cardiff CF24 3AA, Wales..
    Matthew, S.
    Univ Edinburgh, Inst Astron, Royal Observ, Blackford Hill, Edinburgh EH9 3HJ, Scotland..
    Mauri, N.
    INFN, Sez Bologna, Viale Berti Pichat 6-2, I-40127 Bologna, Italy.;Alma Mater Studiorum Univ Bologna, Dipartimento Fis & Astron Augusto Righi, Viale Berti Pichat 6-2, I-40127 Bologna, Italy..
    Pezzotta, A.
    Max Planck Inst Extraterr Phys, Giessenbachstr 1, D-85748 Garching, Germany..
    Pontinen, M.
    Univ Helsinki, Dept Phys, POB 64, Helsinki 00014, Finland..
    Scottez, V.
    Inst Astrophys Paris, 98bis Blvd Arago, F-75014 Paris, France.;Univ Catholique Lille, ICL, Junia, LITL, F-59000 Lille, France..
    Tenti, M.
    INFN, Sez Bologna, Viale Berti Pichat 6-2, I-40127 Bologna, Italy..
    Viel, M.
    Inst Fundamental Phys Universe, Via Beirut 2, I-34151 Trieste, Italy.;INAF, Osservatorio Astron Trieste, Via GB Tiepolo 11, I-34143 Trieste, Italy.;INFN, Sez Trieste, Via Valerio 2, I-34127 Trieste, TS, Italy.;SISSA, Int Sch Adv Studies, Via Bonomea 265, I-34136 Trieste, TS, Italy.;ICSC Ctr Nazl Ric High Performance Comp Big Data, Via Magnanelli 2, Bologna, Italy..
    Wiesmann, M.
    Univ Oslo, Inst Theoret Astrophys, POB 1029, N-0315 Oslo, Norway..
    Akrami, Y.
    UAM, CSIC, Inst Fis Teor, Campus Cantoblanco, Madrid 28049, Spain.;Case Western Reserve Univ, Dept Phys, CERCA, ISO, 10900 Euclid Ave, Cleveland, OH 44106 USA..
    Anselmi, S.
    Univ Paris, Univ PSL, Observ Paris, Lab Univers & Theories,CNRS, F-92190 Meudon, France.;INFN Padova, Via Marzolo 8, I-35131 Padua, Italy.;Univ Padua, Dipartimento Fis & Astron G Galilei, Via Marzolo 8, I-35131 Padua, Italy..
    Archidiacono, M.
    Univ Milan, Dipartimento Fis Aldo Pontremoli, Via Celoria 16, I-20133 Milan, Italy.;INFN, Sez Milano, Via Celoria 16, I-20133 Milan, Italy..
    Atrio-Barandela, F.
    Univ Salamanca, Dept Fis Fundamental, Plaza Merced S-N, Salamanca 37008, Spain..
    Ballardini, M.
    INAF, Osservatorio Astrofis & Sci Spazio Bologna, via Piero Gobetti 93-3, I-40129 Bologna, Italy.;Univ Ferrara, Dipartimento Fis & Sci Terra, Via Giuseppe Saragat 1, I-44122 Ferrara, Italy.;Ist Nazl Fis Nucl, Sez Ferrara, Via Giuseppe Saragat 1, I-44122 Ferrara, Italy..
    Bertacca, D.
    INFN Padova, Via Marzolo 8, I-35131 Padua, Italy.;INAF Osservatorio Astron Padova, Via Osservatorio 5, I-35122 Padua, Italy.;Univ Padua, Dipartimento Fis & Astron G Galilei, Via Marzolo 8, I-35131 Padua, Italy..
    Blanchard, A.
    Univ Toulouse, Inst Rech Astrophys & Planetol, CNRS, UPS,CNES, 14 Ave Edouard Belin, F-31400 Toulouse, France..
    Blot, L.
    Univ Paris, Univ PSL, Observ Paris, Lab Univers & Theories,CNRS, F-92190 Meudon, France.;Univ Tokyo, Ctr Data Driven Discovery, UTIAS, Kavli IPMU WPI, Kashiwa, Chiba 2778583, Japan..
    Boehringer, H.
    Max Planck Inst Extraterr Phys, Giessenbachstr 1, D-85748 Garching, Germany.;Ludwig Maximilians Univ Munchen, Schellingstr 4, D-80799 Munich, Germany.;Max Planck Inst Phys & Astrophys, Boltzmannstr 8, D-85748 Garching, Germany..
    Bruton, S.
    Univ Minnesota, Minnesota Inst Astrophys, 116 Church St SE, Minneapolis, MN 55455 USA..
    Cabanac, R.
    Univ Toulouse, Inst Rech Astrophys & Planetol, CNRS, UPS,CNES, 14 Ave Edouard Belin, F-31400 Toulouse, France..
    Calabro, A.
    INAF, Osservatorio Astron Roma, Via Frascati 33, I-00078 Monte Porzio Catone, Italy..
    Camacho Quevedo, B.
    CSIC, Inst Space Sci ICE, Campus UAB,Carrer Can Magrans S-N, Barcelona 08193, Spain.;Inst Estudis Espacials Catalunya IEEC, Edifici RDIT,Campus UPC, Barcelona 08860, Spain..
    Cappi, A.
    INAF, Osservatorio Astrofis & Sci Spazio Bologna, via Piero Gobetti 93-3, I-40129 Bologna, Italy.;Univ Cote Azur, Observ Cote Azur, CNRS, Lab Lagrange, Bd Observ,CS 34229, F-06304 Nice 4, France..
    Caro, F.
    INAF, Osservatorio Astron Roma, Via Frascati 33, I-00078 Monte Porzio Catone, Italy..
    Carvalho, C. S.
    Univ Lisbon, Fac Ciencias, Inst Astrofis & Ciencias Espaco, P-1349018 Lisbon, Portugal..
    Castro, T.
    Inst Fundamental Phys Universe, Via Beirut 2, I-34151 Trieste, Italy.;INAF, Osservatorio Astron Trieste, Via GB Tiepolo 11, I-34143 Trieste, Italy.;INFN, Sez Trieste, Via Valerio 2, I-34127 Trieste, TS, Italy.;ICSC Ctr Nazl Ric High Performance Comp Big Data, Via Magnanelli 2, Bologna, Italy..
    Contarini, S.
    Max Planck Inst Extraterr Phys, Giessenbachstr 1, D-85748 Garching, Germany..
    Cooray, A. R.
    Univ Calif Irvine, Dept Phys & Astron, Irvine, CA 92697 USA..
    Desprez, G.
    St Marys Univ, Dept Phys & Astron, 923 Robie St, Halifax, NS B3H 3C3, Canada.;St Marys Univ, Inst Comp Astrophys, 923 Robie St, Halifax, NS B3H 3C3, Canada..
    Diaz-Sanchez, A.
    Univ Politecn Cartagena, Dept Fis Aplicada, Campus Muralla Mar, Murcia 30202, Spain..
    Diaz, J. J.
    Univ La Laguna, Dept Astrofis, Inst Astrofis Canarias, San Cristobal la Laguna 38200, Spain..
    Di Domizio, S.
    Univ Genoa, Dipartimento Fis, Via Dodecaneso 33, I-16146 Genoa, Italy.;INFN, Sez Genova, Via Dodecaneso 33, I-16146 Genoa, Italy..
    Ezziati, M.
    Aix Marseille Univ, CNRS, CNES, LAM, Marseille, France..
    Ferrari, A. G.
    INFN, Sez Bologna, Viale Berti Pichat 6-2, I-40127 Bologna, Italy.;Alma Mater Studiorum Univ Bologna, Dipartimento Fis & Astron Augusto Righi, Viale Berti Pichat 6-2, I-40127 Bologna, Italy..
    Ferreira, P. G.
    Univ Oxford, Dept Phys, Keble Rd, Oxford OX1 3RH, England..
    Ferrero, I.
    Univ Oslo, Inst Theoret Astrophys, POB 1029, N-0315 Oslo, Norway..
    Finoguenov, A.
    Univ Helsinki, Dept Phys, POB 64, Helsinki 00014, Finland..
    Fontana, A.
    INAF, Osservatorio Astron Roma, Via Frascati 33, I-00078 Monte Porzio Catone, Italy..
    Fornari, F.
    INFN Bologna, Via Irnerio 46, I-40126 Bologna, Italy..
    Gabarra, L.
    Univ Oxford, Dept Phys, Keble Rd, Oxford OX1 3RH, England..
    Ganga, K.
    Univ Paris Cite, CNRS, Astroparticule & Cosmol, F-75013 Paris, France..
    Garcia-Bellido, J.
    UAM, CSIC, Inst Fis Teor, Campus Cantoblanco, Madrid 28049, Spain..
    Gasparetto, T.
    INAF, Osservatorio Astron Trieste, Via GB Tiepolo 11, I-34143 Trieste, Italy..
    Gautard, V.
    CEA Saclay, DFR, IRFU, Serv Astrophys, Bat 709, F-91191 Gif Sur Yvette, France..
    Gaztanaga, E.
    Univ Portsmouth, Inst Cosmol & Gravitat, Portsmouth PO1 3FX, Hants, England.;CSIC, Inst Space Sci ICE, Campus UAB,Carrer Can Magrans S-N, Barcelona 08193, Spain.;Inst Estudis Espacials Catalunya IEEC, Edifici RDIT,Campus UPC, Barcelona 08860, Spain..
    Giacomini, F.
    INFN, Sez Bologna, Viale Berti Pichat 6-2, I-40127 Bologna, Italy..
    Gianotti, F.
    INAF, Osservatorio Astrofis & Sci Spazio Bologna, via Piero Gobetti 93-3, I-40129 Bologna, Italy..
    Gozaliasl, G.
    Univ Helsinki, Dept Phys, POB 64, Helsinki 00014, Finland.;Aalto Univ, Dept Comp Sci, POB 15400, FI-00076 Espoo, Finland..
    Gutierrez, C. M.
    Inst Astrofis Canarias, C Via Lactea S-N, San Cristobal la Laguna 38200, Spain.;Univ La Laguna, Dept Astrofis, Avda Francisco Sanchez, San Cristobal la Laguna 38200, Spain..
    Hall, A.
    Univ Edinburgh, Inst Astron, Royal Observ, Blackford Hill, Edinburgh EH9 3HJ, Scotland..
    Hildebrandt, H.
    Ruhr Univ Bochum, Astron Inst AIRUB, Fac Phys & Astron, German Ctr Cosmol Lensing GCCL, D-44780 Bochum, Germany..
    Hjorth, J.
    Univ Copenhagen, Niels Bohr Inst, DARK, Jagtvej 155, DK-2200 Copenhagen, Denmark..
    Jimenez Munoz, A.
    Univ Grenoble Alpes, CNRS, Grenoble INP, LPSC,IN2P3, 53 Ave Martyrs, F-38000 Grenoble, France..
    Joudaki, S.
    Univ Portsmouth, Inst Cosmol & Gravitat, Portsmouth PO1 3FX, Hants, England..
    Kajava, J. J. E.
    Univ Turku, Dept Phys & Astron, Vesilinnantie 5, Turku 20014, Finland.;Serco European Space Agcy ESA, Camino Bajo Castillo S-N, Madrid 28692, Spain..
    Kansal, V.
    ARC Ctr Excellence Dark Matter Particle Phys, Melbourne, Vic, Australia.;Swinburne Univ Technol, Ctr Astrophys & Supercomp, Hawthorn, Vic 3122, Australia..
    Karagiannis, D.
    Queen Mary Univ London, Sch Phys & Astron, Mile End Rd, London E1 4NS, England.;Univ Western Cape, Dept Phys & Astron, ZA-7535 Cape Town, South Africa..
    Kirkpatrick, C. C.
    Univ Helsinki, Dept Phys, Gustaf Hallstromin Katu 2, Helsinki 00014, Finland.;Univ Helsinki, Helsinki Inst Phys, Gustaf Hallstromin Katu 2, Helsinki 00014, Finland..
    Le Graet, J.
    Aix Marseille Univ, CNRS, IN2P3, CPPM, Marseille, France..
    Legrand, L.
    Univ Estadual Paulista, Inst Fis Teor, ICTP South Amer Inst Fundamental Res, Sao Paulo, Brazil..
    Lesgourgues, J.
    Rhein Westfal TH Aachen, Inst Theoret Particle Phys & Cosmol TTK, D-52056 Aachen, Germany..
    Liaudat, T. I.
    Univ Paris Saclay, IRFU, CEA, F-91191 Gif Sur Yvette, France..
    Liu, S. J.
    INAF Ist Astrofis & Planetol Spaziali, Via Fosso Cavaliere 100, I-00100 Rome, Italy..
    Loureiro, A.
    Stockholm Univ, Dept Phys, Oskar Klein Ctr Cosmoparticle Phys, SE-10691 Stockholm, Sweden.;Imperial Coll London, Blackett Lab, Astrophys Grp, London SW7 2AZ, England..
    Maggio, G.
    INAF, Osservatorio Astron Trieste, Via GB Tiepolo 11, I-34143 Trieste, Italy..
    Magliocchetti, M.
    INAF Ist Astrofis & Planetol Spaziali, Via Fosso Cavaliere 100, I-00100 Rome, Italy..
    Mannucci, F.
    INAF Osservatorio Astrofis Arcetri, Largo E Fermi 5, I-50125 Florence, Italy..
    Maoli, R.
    INAF, Osservatorio Astron Roma, Via Frascati 33, I-00078 Monte Porzio Catone, Italy.;Sapienza Univ Roma, Dipartimento Fis, Piazzale Aldo Moro 2, I-00185 Rome, Italy..
    Martin-Fleitas, J.
    Aurora Technol European Space Agcy ESA, Camino Bajo Castillo S-N, Madrid 28692, Spain..
    Martins, C. J. A. P.
    Univ Porto, Inst Astrofis & Ciencias Espaco, CAUP, Rua Estrelas, PT-4150762 Porto, Portugal.;Univ Porto, Ctr Astrofis, Rua Estrelas, P-4150762 Porto, Portugal..
    Maurin, L.
    Univ Paris Saclay, CNRS, Inst Astrophys Spatiale, F-91405 Orsay, France..
    Metcalf, R. B.
    INAF, Osservatorio Astrofis & Sci Spazio Bologna, via Piero Gobetti 93-3, I-40129 Bologna, Italy.;Alma Mater Studiorum Univ Bologna, Dipartimento Fis & Astron Augusto Righi, Via Piero Gobetti 93-2, I-40129 Bologna, Italy..
    Miluzio, M.
    ESA, ESAC, Camino Bajo Castillo S-N, Madrid 28692, Spain.;HE Space European Space Agcy ESA, Camino Bajo Castillo S-N, Madrid 28692, Spain..
    Monaco, P.
    Inst Fundamental Phys Universe, Via Beirut 2, I-34151 Trieste, Italy.;INAF, Osservatorio Astron Trieste, Via GB Tiepolo 11, I-34143 Trieste, Italy.;INFN, Sez Trieste, Via Valerio 2, I-34127 Trieste, TS, Italy.;Univ Trieste, Dipartimento Fis, Sez Astron, Via Tiepolo 11, I-34131 Trieste, Italy..
    Montoro, A.
    CSIC, Inst Space Sci ICE, Campus UAB,Carrer Can Magrans S-N, Barcelona 08193, Spain.;Inst Estudis Espacials Catalunya IEEC, Edifici RDIT,Campus UPC, Barcelona 08860, Spain..
    Moretti, C.
    Inst Fundamental Phys Universe, Via Beirut 2, I-34151 Trieste, Italy.;INAF, Osservatorio Astron Trieste, Via GB Tiepolo 11, I-34143 Trieste, Italy.;INFN, Sez Trieste, Via Valerio 2, I-34127 Trieste, TS, Italy.;SISSA, Int Sch Adv Studies, Via Bonomea 265, I-34136 Trieste, TS, Italy.;ICSC Ctr Nazl Ric High Performance Comp Big Data, Via Magnanelli 2, Bologna, Italy..
    Morgante, G.
    INAF, Osservatorio Astrofis & Sci Spazio Bologna, via Piero Gobetti 93-3, I-40129 Bologna, Italy..
    Murray, C.
    Univ Paris Cite, CNRS, Astroparticule & Cosmol, F-75013 Paris, France..
    Nadathur, S.
    Univ Portsmouth, Inst Cosmol & Gravitat, Portsmouth PO1 3FX, Hants, England..
    Pagano, L.
    Univ Ferrara, Dipartimento Fis & Sci Terra, Via Giuseppe Saragat 1, I-44122 Ferrara, Italy.;Ist Nazl Fis Nucl, Sez Ferrara, Via Giuseppe Saragat 1, I-44122 Ferrara, Italy..
    Patrizii, L.
    INFN, Sez Bologna, Viale Berti Pichat 6-2, I-40127 Bologna, Italy..
    Popa, V.
    Inst Space Sci, Str Atomistilor 409, Ilfov 077125, Romania..
    Potter, D.
    Univ Zurich, Dept Astrophys, Winterthurerstr 190, CH-8057 Zurich, Switzerland..
    Reimberg, P.
    Inst Astrophys Paris, 98bis Blvd Arago, F-75014 Paris, France..
    Risso, I.
    Univ Genoa, Dipartimento Fis, Via Dodecaneso 33, I-16146 Genoa, Italy.;INFN, Sez Genova, Via Dodecaneso 33, I-16146 Genoa, Italy..
    Rocci, P. -F
    Sahlén, Martin
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Theoretical Astrophysics.
    Sarpa, E.
    INFN, Sez Trieste, Via Valerio 2, I-34127 Trieste, TS, Italy.;SISSA, Int Sch Adv Studies, Via Bonomea 265, I-34136 Trieste, TS, Italy.;ICSC Ctr Nazl Ric High Performance Comp Big Data, Via Magnanelli 2, Bologna, Italy..
    Schneider, A.
    Univ Zurich, Dept Astrophys, Winterthurerstr 190, CH-8057 Zurich, Switzerland..
    Sereno, M.
    INAF, Osservatorio Astrofis & Sci Spazio Bologna, via Piero Gobetti 93-3, I-40129 Bologna, Italy.;INFN, Sez Bologna, Viale Berti Pichat 6-2, I-40127 Bologna, Italy..
    Silvestri, A.
    Leiden Univ, Inst Lorentz, Niels Bohrweg 2, NL-2333 CA Leiden, Netherlands..
    Stadel, J.
    Univ Zurich, Dept Astrophys, Winterthurerstr 190, CH-8057 Zurich, Switzerland..
    Tanidis, K.
    Univ Oxford, Dept Phys, Keble Rd, Oxford OX1 3RH, England..
    Tao, C.
    Aix Marseille Univ, CNRS, IN2P3, CPPM, Marseille, France..
    Testera, G.
    INFN, Sez Genova, Via Dodecaneso 33, I-16146 Genoa, Italy..
    Teyssier, R.
    Princeton Univ, Dept Astrophys Sci, Peyton Hall, Princeton, NJ 08544 USA..
    Tosi, S.
    Univ Genoa, Dipartimento Fis, Via Dodecaneso 33, I-16146 Genoa, Italy.;INFN, Sez Genova, Via Dodecaneso 33, I-16146 Genoa, Italy..
    Troja, A.
    INFN Padova, Via Marzolo 8, I-35131 Padua, Italy.;Univ Padua, Dipartimento Fis & Astron G Galilei, Via Marzolo 8, I-35131 Padua, Italy..
    Tucci, M.
    Univ Geneva, Dept Astron, Ch Ecogia 16, CH-1290 Versoix, Switzerland..
    Vergani, D.
    INAF, Osservatorio Astrofis & Sci Spazio Bologna, via Piero Gobetti 93-3, I-40129 Bologna, Italy..
    Verza, G.
    NYU, Dept Phys, Ctr Cosmol & Particle Phys, New York, NY 10003 USA.;Flatiron Inst, Ctr Computat Astrophys, 162 5th Ave, New York, NY 10010 USA..
    Vielzeuf, P.
    Aix Marseille Univ, CNRS, IN2P3, CPPM, Marseille, France..
    Walton, N. A.
    Univ Cambridge, Inst Astron, Madingley Rd, Cambridge CB3 0HA, England..
    Euclid preparation: LXXI. Simulations and nonlinearities beyond ΛCDM. 3. Constraints on f(R) models from the photometric primary probes2025In: Astronomy and Astrophysics, ISSN 0004-6361, E-ISSN 1432-0746, Vol. 698, article id A233Article in journal (Refereed)
    Abstract [en]

    We study the constraint on f(R) gravity that can be obtained by photometric primary probes of the Euclid mission. Our focus is the dependence of the constraint on the theoretical modelling of the nonlinear matter power spectrum. In the Hu-Sawicki f(R) gravity model, we consider four different predictions for the ratio between the power spectrum in f(R) and that in Lambda cold dark matter (Lambda CDM): a fitting formula, the halo model reaction approach, ReACT, and two emulators based on dark matter only N-body simulations, FORGE and e-Mantis. These predictions are added to the MontePython implementation to predict the angular power spectra for weak lensing (WL), photometric galaxy clustering, and their cross-correlation. By running Markov chain Monte Carlo, we compare constraints on parameters and investigate the bias of the recovered f(R) parameter if the data are created by a different model. For the pessimistic setting of WL, one-dimensional bias for the f(R) parameter, log10|fR0|, is found to be 0.5 sigma when FORGE is used to create the synthetic data with log10|fR0| = -5.301 and fitted by e-Mantis. The impact of baryonic physics on WL is studied by using a baryonification emulator, BCemu. For the optimistic setting, the f(R) parameter and two main baryonic parameters are well constrained despite the degeneracies among these parameters. However, the difference in the nonlinear dark matter prediction can be compensated for the adjustment of baryonic parameters, and the one-dimensional marginalised constraint on log10|fR0| is biased. This bias can be avoided in the pessimistic setting at the expense of weaker constraints. For the pessimistic setting, using the Lambda CDM synthetic data for WL, we obtain the prior-independent upper limit of log10|fR0| < -5.6. Finally, we implement a method to include theoretical errors to avoid the bias due to inaccuracies in the nonlinear matter power spectrum prediction.

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    FULLTEXT01
  • Aad, G.
    et al.
    Aix Marseille Univ, CNRS, IN2P3, CPPM, Marseille, France.
    Bergeås Kuutmann, Elin
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Brenner, Richard
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Dimitriadi, Christina
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ekelöf, Tord
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ellajosyula, Venugopal
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ellert, Mattias
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ferrari, Arnaud
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Gonzalez Suarez, Rebeca
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Mathisen, Thomas
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Mullier, Geoffrey A.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ripellino, Giulia
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Steentoft, Jonas
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Sunneborn Gudnadottir, Olga
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Wang, Z.
    Duke Univ, Dept Phys, Durham, NC 27706 USA;Shanghai Jiao Tong Univ, Sch Phys & Astron, Key Lab Particle Astrophys & Cosmol, SKLPPC,MOE, Shanghai, Peoples R China;Tsung Dao Lee Inst, Shanghai, Peoples R China;Univ Michigan, Dept Phys, Ann Arbor, MI 48109 USA.
    Measurement of the Lund jet plane in hadronic decays of top quarks and W bosons with the ATLAS detector2025In: European Physical Journal C, ISSN 1434-6044, E-ISSN 1434-6052, Vol. 85, no 4, article id 416Article in journal (Refereed)
    Abstract [en]

    The Lund jet plane (LJP) is measured for the first time in t (t) over bar events, using 140 fb(-1) of root s = 13 TeV pp collision data collected with the ATLAS detector at the LHC. The LJP is a two-dimensional observable of the sub-structure of hadronic jets that acts as a proxy for the kinematics of parton showers and hadron formation. The observable is constructed from charged particles and is measured for R = 1.0 anti-k(t) jets with transverse momentum above 350 GeV containing the full decay products of either a top quark or a daughter W boson. The other top quark in the event is identified from its decay into a b-quark, an electron or a muon and a neutrino. The measurement is corrected for detector effects and compared with a range of Monte Carlo predictions sensitive to different aspects of the hadronic decays of the heavy particles. In the W-boson-initiated jets, all the predictions are incompatible with the measurement. In the top quark initiated jets, disagreement with all predictions is observed in smaller subregions of the plane, and with a subset of the predictions across the fiducial plane. The measurement could be used to improve the tuning of Monte Carlo generators, for better modelling of hadronic decays of heavy quarks and bosons, or to improve the performance of jet taggers.

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    FULLTEXT01
  • Wikström, N.
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Physics. KTH Royal Inst Technol, Dept Phys, Stockholm, Sweden..
    Giamouridou, M.
    KTH Royal Inst Technol, Dept Phys, Stockholm, Sweden..
    Charatsidou, E.
    KTH Royal Inst Technol, Dept Phys, Stockholm, Sweden..
    Olsson, P.
    KTH Royal Inst Technol, Dept Phys, Stockholm, Sweden..
    Oscarsson, Johan
    Uppsala University, Disciplinary Domain of Science and Technology, För teknisk-naturvetenskapliga fakulteten gemensamma enheter, Tandem Laboratory.
    Primetzhofer, Daniel
    Uppsala University, Disciplinary Domain of Science and Technology, För teknisk-naturvetenskapliga fakulteten gemensamma enheter, Tandem Laboratory. Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Physics.
    Frost, Robert J. W.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Physics.
    Assessing the near-surface diffusion of Xe and Kr in Zirconia by time-of-flight elastic recoil detection analysis2025In: Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, ISSN 0168-583X, E-ISSN 1872-9584, Vol. 566, article id 165773Article in journal (Refereed)
    Abstract [en]

    The diffusion of two volatile fission products, xenon (Xe) and krypton (Kr), in zirconia (ZrO2) is investigated. Samples of Yttria (Y2O3)-stabilised tetragonal ZrO2 were implanted with either Xe or Kr, at 300 key, with a fluence of 1017 at./cm2, and subsequently analysed with time-of-flight elastic recoil detection analysis (ToF-ERDA) to obtain elemental composition depth profiles. Samples were then annealed at 1200 degrees C for 9 h, and the effect of the annealing was assessed by ToF-ERDA measurements. From these measurements, first-order approximations of diffusion coefficients for Xe and Kr in ZrO2 were derived, using a model based on Fick's second law, these being (1.36 +/- 0.87) x 10-19 m2/s and (2.94 +/- 1.96) x 10-19 m2/s at 1200 degrees C for Kr and Xe respectively. It was shown that ToF-ERDA can provide data to analyse the diffusion of elements in solid sample matrices and that a model based on Fick's Law can predict the diffusion of the implanted ions.

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    fulltext
  • Vomschee, Kevin
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Physics.
    Holeňák, Radek
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Physics.
    Sivagnanalingam, Thanush
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Physics.
    Ntemou, Eleni
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Physics.
    Primetzhofer, Daniel
    Uppsala University, Disciplinary Domain of Science and Technology, För teknisk-naturvetenskapliga fakulteten gemensamma enheter, Tandem Laboratory. Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Physics.
    A note on extracting electronic stopping powers of solid matter for heavy ions from energy loss spectra recorded in transmission geometry2025In: Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, ISSN 0168-583X, E-ISSN 1872-9584, Vol. 566, article id 165772Article in journal (Refereed)
    Abstract [en]

    We describe and compare two techniques to extract the electronic stopping power of solid materials for energetic ions from energy loss spectra recorded in transmission geometry. Particular attention is attributed to the contribution of the nuclear energy loss to the total energy loss. Energy loss spectra were measured for slow N+ and Ar+ projectiles transmitted through 200 nm (N+ projectile) and 50 nm (Ar+ projectile) thick SiC membranes. The measured energy losses are successfully separated into electronic and nuclear losses with the help of a Binary Collision Approximation (BCA) code. The simulations show that the nuclear stopping power in any forward scattering geometry strongly deviates from SRIM predictions. Electronic stopping powers are calculated by two different iterative processes, yielding electronic stopping power at the mean energy or the energy for the mean stopping. The accuracy of the electronic stopping functions gained from these methods is verified by controlling whether the BCA code predicts the measured energy losses correctly using these functions for the simulated electronic stopping power. We show that both algorithms are suitable for extracting the electronic stopping power, even if it shows a pronounced non-linear energy dependence and if the contribution from elastic scattering to the energy loss is large. We compare their performance and show that simultaneous iteration of the electronic and nuclear stopping power provides the most accurate results.

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    fulltext
  • Ablikim, M.
    et al.
    Inst High Energy Phys, Beijing 100049, Peoples R China.
    Adlarson, Patrik
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Johansson, Tord
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Kupsc, Andrzej
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics. Natl Ctr Nucl Res, PL-02093 Warsaw, Poland.
    Schönning, Karin
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Wolke, Magnus
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Zu, J.
    State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China;Univ Sci & Technol China, Hefei 230026, Peoples R China.
    Observation of the decay ؈(3686) → Σ0Σ<over-bar>0ω2025In: Physical Review D: covering particles, fields, gravitation, and cosmology, ISSN 2470-0010, E-ISSN 2470-0029, Vol. 111, no 9, article id 092007Article in journal (Refereed)
    Abstract [en]

    Using a dataset of (27.12 ± 0.14) x 108 ψ(3686) events collected by the BESIII detector operating at the BEPCII collider, we report the first observation of the decay ψ(3686) → Σ0Σ<over bar>0ω. with a statistical significance of 8.9σ. The measured branching fraction is (1.24 ± 0.16stat ± 0.11sys) x 10-5, where the first uncertainty is statistical and the second is systematic. Additionally, we investigate potential intermediate states in the invariant mass distributions of Σ0ω, Σ<over bar>0ω. and Σ0Σ<over bar>0ω. A hint of a resonance is observed in the invariant mass distribution of MΣ0(Σ<over bar>0, located around 2.06 GeV/c2, with a significance of 2.5σ.

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  • Ablikim, M.
    et al.
    Inst High Energy Phys, Beijing 100049, Peoples R China.
    Adlarson, Patrik
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Johansson, Tord
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Kupsc, Andrzej
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics. Natl Ctr Nucl Res, PL-02093 Warsaw, Poland.
    Schönning, Karin
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Thorén, Viktor
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Wolke, Magnus
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Nuclear Physics.
    Zu, J.
    State Key Lab Particle Detect & Elect, Beijing 100049, Peoples R China;Univ Sci & Technol China, Hefei 230026, Peoples R China.
    Measurement of the branching fraction of D→ τ+ντ2025In: Journal of High Energy Physics (JHEP), ISSN 1126-6708, E-ISSN 1029-8479, article id 089Article in journal (Refereed)
    Abstract [en]

    By analyzing e+e- collision data with an integrated luminosity of 7.9 fb-1 collected with the BESIII detector at the center-of-mass energy of 3.773 GeV, the branching fraction of D+→ τ+ντ is determined as B = (9.9 ± 1.1stat ± 0.5syst) x 10-4. Using the most precise result B(D+ → μ+νμ) = (3.981 ± 0.079stat ± 0.040syst) x 10-4 [1], we determine Rτ/μ = Γ(D+ → τ+ντ)/Γ(D+ → μ+νμ) = 2.49 ± 0.31, achieving a factor of two improvement in precision compared to the previous BESIII result. This measurement is in agreement with the standard model prediction of lepton flavor universality within one standard deviation.

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  • Bruinsma, R. A.
    et al.
    Gelre Hosp, Dept Pediat, POB 9014, NL-7300 DS Apeldoorn, Netherlands.;Univ Amsterdam, Amsterdam UMC Multidisciplinary Lyme Borreliosis C, Amsterdam UMC Med Ctr, Locat AMC, Amsterdam, Netherlands.;Univ Amsterdam, Amsterdam Inst Immunol & Infect Dis, Amsterdam UMC Med Ctr, Amsterdam, Netherlands..
    Hedin Skogman, Barbro
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Disciplinary Domain of Medicine and Pharmacy, research centers etc., Center for Clinical Research Dalarna. Örebro Univ, Fac Med & Hlth, Örebro, Sweden..
    van Hensbroek, M. Boele
    Univ Amsterdam, Amsterdam Med Ctr, Dept Pediat, Amsterdam, Netherlands..
    Vermeeren, Y. M.
    Gelre Hosp, Dept Internal Med, Apeldoorn, Netherlands..
    Hovius, J. W.
    Univ Amsterdam, Amsterdam UMC Multidisciplinary Lyme Borreliosis C, Amsterdam UMC Med Ctr, Locat AMC, Amsterdam, Netherlands.;Univ Amsterdam, Amsterdam Inst Immunol & Infect Dis, Amsterdam UMC Med Ctr, Amsterdam, Netherlands..
    Zomer, T. P.
    Gelre Hosp, Dept Internal Med, Apeldoorn, Netherlands..
    Long-term clinical outcomes after Lyme neuroborreliosis in children2025In: BMC Pediatrics, E-ISSN 1471-2431, Vol. 25, article id 511Article in journal (Refereed)
    Abstract [en]

    Background: Lyme neuroborreliosis (LNB) is a tick-borne infection caused by spirochetes of the Borrelia burgdorferi sensu lato complex. Facial nerve palsy and subacute meningitis are the most prevalent neurological manifestations. Long-term prognosis is a major concern of many parents. These concerns relate to persisting neurological deficiencies as well as long-term non-specific symptoms such as fatigue. The aim of this study is to determine long-term outcome in pediatric LNB by using patient-reported outcome measures (PROMs) of facial impairment and self-reported fatigue and to compare these outcomes between children with LNB and idiopathic facial nerve palsy (IFP).

    Methods: A long-term follow-up study was performed including all children (< 18 years) who visited the departments of pediatrics, neurology, or otorhinolaryngology of Gelre hospitals Apeldoorn and Zutphen between 1 January 2010 and 31 December 2023 with the diagnosis LNB or IFP. After consent, children and/or parents (or guardians) were invited to complete an electronic questionnaire, including the Facial Clinimetric Evaluation (FaCE) scale and the Checklist Individual Strength (CIS).

    Results: During the study period, 105 children were identified with facial nerve palsy and 4 with LNB with only headache. These 4 patients with meningitis but without facial nerve palsy were not included in further analyses. Seven children were lost to follow up. In total, 102 children were invited to complete the questionnaires, of which 84 responded (82%) after a median follow-up period of 93.5 months after the acute facial nerve palsy. The median total score of the FaCE scale was 99.2 (IQR 89.2-100) in children with LNB and 98.3 (IQR 93.3-100) in children with IFP and results did not differ between groups (p = 0.787). There were no significant differences between patients with LNB and IFP in the CIS total score (median (IQR), respectively 42.0 (26.3-69.5) versus 48.0 (40.3-60.5) (p = 0.301)).

    Conclusions: This long-term follow-up study adds new data on self/parent reported disease specific outcomes in children with facial nerve palsy from two important patient groups (LNB and IFP). Both facial impairment and fatigue were uncommon and did not differ between LNB and IFP patients at long-term follow-up.

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  • Rojo, M.
    et al.
    Inst Rech Astrophys & Planetol IRAP, UPS, CNES, CNRS, Toulouse, France..
    Reville, V.
    Inst Rech Astrophys & Planetol IRAP, UPS, CNES, CNRS, Toulouse, France..
    Aizawa, S.
    Univ Paris Saclay, Sorbonne Univ, Inst Polytech Paris, Ecole Polytech,Observ Paris,Lab Phys Plasmas LPP,C, F-91120 Palaiseau, France..
    Varsani, A.
    Inst Weltraumforsch IWF, Graz, Austria..
    Schmid, D.
    Inst Weltraumforsch IWF, Graz, Austria..
    Jarry, M.
    Inst Rech Astrophys & Planetol IRAP, UPS, CNES, CNRS, Toulouse, France..
    Rodriguez-Garcia, L.
    European Space Astron Ctr ESAC, Madrid, Spain.;Univ Alcala, Space Res Grp SRG UAH, Plaza San Diego S-N, Alcala De Henares 28801, Madrid, Spain..
    Persson, Moa
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Swedish Institute of Space Physics, Uppsala Division.
    Rouillard, A.
    Inst Rech Astrophys & Planetol IRAP, UPS, CNES, CNRS, Toulouse, France..
    Heyner, D.
    Tech Univ Carolo Wilhelmina Braunschweig, Inst Geophys & Extraterr Phys, Braunschweig, Germany..
    Milillo, A.
    Ist Nazl Astrofis, Rome, Italy..
    Andre, N.
    Inst Rech Astrophys & Planetol IRAP, UPS, CNES, CNRS, Toulouse, France.;Univ Toulouse, Inst Super Aeronaut & Espace ISAE SUPAERO, Toulouse, France..
    Saito, Y.
    Japan Aerosp Explorat Agcy, Inst Space & Astronaut Sci, Sagamihara, Japan..
    Murakami, G.
    Japan Aerosp Explorat Agcy, Inst Space & Astronaut Sci, Sagamihara, Japan..
    Kasper, J. C.
    Univ Michigan, Dept Climate & Space Sci, Ann Arbor, MI USA..
    Bale, S. D.
    Univ Calif Berkeley, Phys Dept, Berkeley, CA USA.;Univ Calif Berkeley, Space Sci Lab, Berkeley, CA USA..
    Characterization of the solar wind context during the third Mercury flyby of BepiColombo2025In: Astronomy and Astrophysics, ISSN 0004-6361, E-ISSN 1432-0746, Vol. 698, article id A221Article in journal (Refereed)
    Abstract [en]

    Context: The interaction of the solar wind (SW) with the coupled magnetosphere-exosphere-surface of Mercury is complex. Charged particles released by the SW can precipitate along planetary magnetic field lines on specific areas of the surface of the planet. The processes responsible for the particle precipitation strongly depend on the orientation of the interplanetary magnetic field (IMF) upstream of Mercury.

    Aims: During the third Mercury flyby (MFB3) by BepiColombo, the properties of the SW inferred from BepiColombo observations of a highly compressed magnetosphere corresponded to those of a very dense plasma embedded in a slow SW. The Mercury Electron Analyzer (MEA) measured continuous high-energy electron fluxes in the nightside dawn sector of the compressed magnetosphere. In order to constrain further studies related to the origin of these populations, we aim to firmly confirm the initial inferences and detail the SW properties throughout MFB3.

    Methods: We took advantage of a close radial alignment between Parker Solar Probe (PSP) and Mercury. We monitored the activity of the Sun using SOHO coronagraphs and we used a potential field source surface model to estimate the location of the magnetic footpoints of PSP and BepiColombo on the photosphere of the Sun. We propagated the plasma parameters and the IMF measured by PSP at BepiColombo, to check if the plasma impacted Mercury.

    Results: We show that during MFB3, PSP and BepiColombo connected magnetically to the same region at the solar surface. The slow SW perturbation first measured at PSP propagated to Mercury and BepiColombo, as was confirmed by similarly elevated plasma densities measured at PSP and BepiColombo. The IMF orientation stayed southward during the whole MFB3.

    Conclusions: Our results provide strong constraints for future studies of the magnetospheric structure and dynamics during MFB3, including tail reconnection, electron and ion energization, and subsequent plasma precipitation onto the surface of Mercury.

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  • Broden, Karin
    et al.
    Karlstad Univ, Serv Ctr Res, Karlstad, Sweden..
    Andersson, Jonas
    Karlstad Univ, Dept Psychol, Karlstad, Sweden..
    Kitkowska, Agnieszka
    Jönköping Univ, Sch Educ & Commun, Jönköping, Sweden..
    Ahmad, Awais
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Computerized Image Analysis and Human-Computer Interaction.
    Mozelius, Peter
    Mid Sweden Univ, Dept Educ, Sundsvall, Sweden..
    Gathering requirements for IoT-assisted wellbeing in elementary school-a multi-stakeholder perspective2025In: Frontiers in Education, E-ISSN 2504-284X, Vol. 10, article id 1580666Article in journal (Refereed)
    Abstract [en]

    Introduction: Students experiencing poor wellbeing in elementary school can suffer lifelong consequences, including low self-esteem or depression. Understanding how to increase student wellbeing through information-based approaches is therefore important. While previous research has explored wellbeing frameworks, this study uniquely investigates the intersection of elementary school wellbeing with Internet of Things (IoT) implementation potential.

    Method: We present the first comprehensive requirements analysis gathered from both staff and students for improving wellbeing in an elementary school in rural Sweden, with the aim of implementing IoT solutions. We collected qualitative data through individual interviews and workshops with 25 staff members and a survey from 464 students. We analyzed the data in an inductively and deductively way, using the Konu and Rimpel & auml;'s wellbeing framework.

    Results: Our novel findings reveal alignment between staff and student perspectives across the framework's categories: having, loving, being and health. One example is the importance of motivation in each learning situation and creating a foundation for good social relations among the students. The requirements related to the health category received the least attention, reflecting less focus on individual student circumstances.

    Discussion: This study contributes new knowledge by detailing wellbeing needs for elementary school and relating them to data-driven innovation, such as IoT, for gathering both objective and subjective information. We also acknowledge that this creates additional demands on current solutions and raises significant privacy concerns in school environments. Future research will incorporate expert IoT knowledge and develop prototype solution based on these identified requirements.

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  • Alemu, Kassahun
    et al.
    Univ Gondar, Gondar, Ethiopia..
    Berhanu, Della
    London Sch Hyg & Trop Med, Dis Control, London, England..
    Bergström, Anna
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.
    Hoa, Dinh Phuong
    Vietnam Publ Hlth Assoc, Hanoi, Vietnam. Makerere Univ, Sch Publ Hlth, Dept Hlth Policy Planning & Management, Kampala, Uganda. Karolinska Inst, Dept Global Publ Hlth, Stockholm, Sweden..
    Swartling Peterson, Stefan
    Phoummalaysith, Bounfeng
    Minist Hlth, Warsaw, Poland..
    Tomson, Goran
    Karolinska Inst, Dept Learning Informat Management & Eth, Stockholm, Sweden..
    Wanyenze, Rhoda Kitti
    Makerere Univ, Sch Publ Hlth, Dept Dis Control & Environm Hlth, Kampala, Uganda..
    Persson, Lars Ake
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. London Sch Hyg & Trop Med, Dis Control, London, England..
    Towards equitable partnerships in global health research: experiences from Ethiopia, Uganda, Lao PDR and Vietnam2025In: BMJ Global Health, E-ISSN 2059-7908, Vol. 10, no 6, article id e019130Article in journal (Refereed)
    Abstract [en]

    Equitable partnerships in global health research can counteract power imbalances in this field. Theoretical perspectives have been provided on equitable global health partnerships, but there are few reports from researchers actively engaged in such partnerships. This article departs from the experiences of four long-term global health research partnerships, two in Africa and two in Asia. It describes the challenges in enhancing an equitable research partnership and how these were addressed. The examples illustrate that funders can play a pivotal role in counteracting power imbalances by assigning leadership roles and directing primary funding to institutions where the research occurs. Such a transition requires adaptations and a new mindset on both sides. Embedded research capacity enhancement, part of all four partnership examples, is essential in correcting power imbalances. Capacity enhancement should preferably include enhancing the broader research ecosystem within the partner university, across academic institutions in the country or beyond. The development of mutual trust and respect takes time and requires long-term engagement, transparency in budgeting, project planning and all steps of the research process. Reciprocity in learning is important for all partners. It may include twinning of research students, joint degrees and efforts to bring research findings into policy and practice in all partner contexts. The partnership examples illustrate the achievements and challenges in bringing new research evidence into policy and practice, where early involvement and continuous buy-in by policymakers are crucial.

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  • Rauer, Heike
    et al.
    DLR, Inst Planetenforsch, Deutsch Zentrum Luft & Raumfahrt, Rutherfordstr 2, D-12489 Berlin, Germany;Free Univ Berlin, Inst Geol, Fachbereich Geowissensch, Malteserstr 74-100, D-12249 Berlin, Germany.
    Amarsi, Anish
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Theoretical Astrophysics.
    Barklem, Paul
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Theoretical Astrophysics.
    Eriksson, Kjell
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Theoretical Astrophysics.
    Heiter, Ulrike
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Observational Astrophysics.
    Kochukhov, Oleg
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Observational Astrophysics.
    Olander, Terese
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Observational Astrophysics.
    Dansac, Leo Michel
    Aix Marseille Univ, CNRS, CNES, LAM, Marseille, France.
    The PLATO mission2025In: Experimental astronomy, ISSN 0922-6435, E-ISSN 1572-9508, Vol. 59, article id 26Article in journal (Refereed)
    Abstract [en]

    PLATO (PLAnetary Transits and Oscillations of stars) is ESA's M3 mission designed to detect and characterise extrasolar planets and perform asteroseismic monitoring of a large number of stars. PLATO will detect small planets (down to <2REarth) around bright stars (<11 mag), including terrestrial planets in the habitable zone of solar-like stars. With the complement of radial velocity observations from the ground, planets will be characterised for their radius, mass, and age with high accuracy (5%, 10%, 10% for an Earth-Sun combination respectively). PLATO will provide us with a large-scale catalogue of well-characterised small planets up to intermediate orbital periods, relevant for a meaningful comparison to planet formation theories and to better understand planet evolution. It will make possible comparative exoplanetology to place our Solar System planets in a broader context. In parallel, PLATO will study (host) stars using asteroseismology, allowing us to determine the stellar properties with high accuracy, substantially enhancing our knowledge of stellar structure and evolution. The payload instrument consists of 26 cameras with 12cm aperture each. For at least four years, themission will perform high-precision photometricmeasurements. Here we review the science objectives, present PLATO's target samples and fields, provide an overview of expected core science performance as well as a description of the instrument and the mission profile towards the end of the serial production of the flight cameras. PLATO is scheduled for a launch date end 2026. This overview therefore provides a summary of the mission to the community in preparation of the upcoming operational phases.

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  • Tullberg, Axel Stenmark
    et al.
    Univ Gothenburg, Sahlgrenska Univ Hosp, Inst Clin Sci, Dept Oncol, S-41345 Gothenburg, Sweden.;Stanford Univ, Dept Med, Stanford, CA USA..
    Thurfjell, Viktoria
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology.
    Kovacs, Aniko
    Sahlgrens Univ Hosp, Dept Clin Pathol, Gothenburg, Sweden.;Univ Gothenburg, Inst Biomed, Sahlgrenska Acad, Gothenburg, Sweden..
    Micke, Patrick
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Cancer Immunotherapy.
    Moustakas, Aristidis
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Killander, Fredrika
    Lund Univ, Skane Univ Hosp, Dept Clin Sci, Div Oncol, Lund, Sweden..
    Nimeus, Emma
    Lund Univ, Dept Clin Sci, Div Surg & Oncol, Lund, Sweden.;Skane Univ Hosp, Dept Surg, Lund, Sweden..
    Holmberg, Erik
    Univ Gothenburg, Sahlgrenska Univ Hosp, Inst Clin Sci, Dept Oncol, S-41345 Gothenburg, Sweden..
    Karlsson, Per
    Univ Gothenburg, Sahlgrenska Univ Hosp, Inst Clin Sci, Dept Oncol, S-41345 Gothenburg, Sweden..
    Strell, Carina
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Cancer Immunotherapy. Univ Bergen, Ctr Canc Biomarkers CCBIO, Dept Clin Med, Bergen, Norway..
    Tumoral pSMAD2 as a prognostic biomarker in early-stage breast cancer: insights from the randomized SweBCG91RT trial2025In: Breast Cancer Research and Treatment, ISSN 0167-6806, E-ISSN 1573-7217, Vol. 212, no 3, p. 499-509Article in journal (Refereed)
    Abstract [en]

    Background/Aim: The TGF-beta pathway can influence breast cancer progression and therapy efficacy, exhibiting both pro- and anti-tumoral effects. This study examined the impact of active TGF-beta signaling on recurrence and radiotherapy (RT) benefit in early-stage breast cancer, using nuclear phosphorylated Smad2 (pSMAD2) as a marker for pathway activation.

    Methods: Tissue-microarrays from 1178 stage I-IIA breast cancer patients in the SweBCG91RT trial (randomized to breast-conserving surgery with or without RT) were analyzed. pSMAD2 immunohistochemistry was scored as the mean percentage of tumor cells with nuclear staining. Recurrence risk and RT benefit were evaluated.

    Results: pSMAD2 scores were heavily skewed, with 45% of tumors demonstrating high staining (>= 80% tumor cells), 38% medium (21-79%), and 17% low (<= 20%). Low pSMAD2 tumors were associated with higher grade and larger size but not with subtype. Medium pSMAD2 tumors had a significantly increased ipsilateral breast tumor recurrence risk than high pSMAD2 tumors (HRadjusted = 1.82, p = 0.002), while no differences were observed for low pSMAD2 tumors. A similar result was obtained with all recurrences as endpoint. RT benefit was consistent across all pSMAD2 groups. In Luminal tumors, higher tumoral pSMAD2 levels were inversely correlated with tumor-infiltrating lymphocytes (TILs).

    Conclusion: Medium pSMAD2 levels were linked to an increased recurrence risk compared to high levels, suggesting a tumor-suppressive role of TGF-beta in early breast tumorigenesis. However, no significant differences were noted for low pSMAD2 levels. In Luminal tumors, TGF-beta signaling was negatively associated with TILs. These findings indicate that therapeutic targeting of TGF-beta warrants careful consideration of tumor stage and subtype.

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  • Baloch, Ramen Munir
    et al.
    INSERM, EPAR, IPLESP, Paris, France.;Sorbonne Univ, Paris, France..
    Magyar, Donat
    Natl Ctr Publ Hlth & Pharm, Budapest, Hungary..
    Rudnai, Peter
    Natl Ctr Publ Hlth & Pharm, Budapest, Hungary..
    Pandics, Tamas
    Natl Ctr Publ Hlth & Pharm, Budapest, Hungary.;Semmelweis Univ, Fac Hlth Sci, Dept Publ Hlth Sci, Budapest, Hungary..
    Remeny-Nagy, Zsuzsanna
    Natl Ctr Publ Hlth & Pharm, Budapest, Hungary..
    Moshammer, Hanns
    Med Univ Vienna, Ctr Publ Hlth, Dept Environm Hlth, Vienna, Austria..
    Leppaenen, Hanna
    Finnish Inst Hlth & Welf, Dept Hlth Secur, Kuopio, Finland..
    Hyvaerinen, Anne
    Finnish Inst Hlth & Welf, Dept Hlth Secur, Kuopio, Finland..
    Taeubel, Martin
    Finnish Inst Hlth & Welf, Dept Hlth Secur, Kuopio, Finland..
    Norbäck, Dan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Occupational and Environmental Medicine.
    Gabriel, Marta
    Inst Sci & Innovat Mech & Ind Engn INEGI, Porto, Portugal..
    Maio, Sara
    Natl Res Council Italy CNR, Inst Clin Physiol IFC, Pisa, Italy..
    Baldacci, Sandra
    Natl Res Council Italy CNR, Inst Clin Physiol IFC, Pisa, Italy..
    Sarno, Giuseppe
    Natl Res Council Italy CNR, Inst Clin Physiol IFC, Pisa, Italy..
    Viegi, Giovanni
    Natl Res Council Italy CNR, Inst Clin Physiol IFC, Pisa, Italy..
    Csobod, Eva
    Natl Ctr Publ Hlth & Pharm, Budapest, Hungary..
    Fernandes, Eduardo de Oliveira
    Univ Porto, Porto, Portugal..
    Annesi-Maesano, Isabella
    INSERM, EPAR, IPLESP, Paris, France.;Sorbonne Univ, Paris, France.;Univ Montpellier, Univ Hosp Inst, Immun4Cure, Montpellier, France.;INSERM, Montpellier, France..
    Endotoxin exposure associated with respiratory health among European schoolchildren: The SINPHONIE study2025In: PULMONOLOGY, ISSN 2531-0437, Vol. 31, no 1, article id 2511417Article in journal (Refereed)
    Abstract [en]

    Background: Evidence on the association between endotoxin exposure and respiratory health in children remains inconsistent, with limited research addressing school environments-key settings for daily exposure. This study investigates the relationship between classroom endotoxin levels and respiratory health among European schoolchildren.

    Methods: Within the EU-funded SINPHONIE project, endotoxin concentrations were measured in 285 classrooms across 102 schools in 22 European countries. A total of 5,140 children completed a standardized health questionnaire; 4,633 had endotoxin data, 4,170 performed spirometry, and 746 underwent fractioned exhaled nitric oxide (FeNO) testing.

    Findings: Endotoxin levels varied geographically, with the highest averages in Italy and the lowest in Finland. After adjusting for confounders, exposure to endotoxin levels at or above the median was associated with higher odds of upper and lower respiratory symptoms-runny nose, nasal obstruction, cough, dry throat, breathing difficulty, and feverishness-as well as reduced lung function (p < 0.05). Meta-analysis by WHO European clusters confirmed these associations, though region-specific analyses indicated a possible protective effect of endotoxin exposure in Northern Europe.

    Interpretation: Findings from SINPHONIE highlight classroom endotoxin as a potential environmental determinant of respiratory health. Reducing exposure in schools-currently an overlooked setting-may support respiratory well-being in children and inform future public health policies.

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  • Aad, G.
    et al.
    Aix Marseille Univ, CNRS, IN2P3, CPPM, Marseille, France.
    Bergeås Kuutmann, Elin
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Brenner, Richard
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ekelöf, Tord
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ellajosyula, Venugopal
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ellert, Mattias
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Ferrari, Arnaud
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Gallén, Axel
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Gonzalez Suarez, Rebeca
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Mullier, Geoffrey A.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Rincke, Philipp
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics. Georg August Univ Gottingen, Phys Inst 2, Gottingen, Germany.
    Ripellino, Giulia
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Sunneborn Gudnadottir, Olga
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, High Energy Physics.
    Zwalinski, L.
    CERN, Geneva, Switzerland.
    Search for a heavy charged Higgs boson decaying into a W boson and a Higgs boson in final states with leptons and b-jets in √s=13 TeV pp collisions with the ATLAS detector2025In: Journal of High Energy Physics (JHEP), ISSN 1126-6708, E-ISSN 1029-8479, article id 143Article in journal (Refereed)
    Abstract [en]

    This article presents a search for a heavy charged Higgs boson produced in association with a top quark and a bottom quark, and decaying into a W boson and a 125 GeV Higgs boson h. The search is performed in final states with one charged lepton, missing transverse momentum, and jets using proton-proton collision data at √s = 13 TeV recorded with the ATLAS detector during Run 2 of the LHC at CERN. This data set corresponds to a total integrated luminosity of 140 fb-1. The search is conducted by examining the reconstructed invariant mass distribution of the Wh candidates for evidence of a localised excess in the charged Higgs boson mass range from 250 GeV to 3 TeV. No significant excess of data over the expected background is observed and 95% confidence-level upper limits between 2.8 pb and 1.2 fb are placed on the production cross-section times branching ratio for charged Higgs bosons decaying into Wh.

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  • Dankowski, J.
    et al.
    Polish Acad Sci, Inst Nucl Phys, Radzikowskiego 152, PL-31342 Krakow, Poland..
    Bielecki, J.
    Polish Acad Sci, Inst Nucl Phys, Radzikowskiego 152, PL-31342 Krakow, Poland..
    Bladek, J.
    Polish Acad Sci, Inst Nucl Phys, Radzikowskiego 152, PL-31342 Krakow, Poland..
    Conroy, Sean
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Applied Nuclear Physics.
    Coriton, B.
    ITER Org, Route Vinon Sur Verdon,CS 90 046, F-13067 St Paul Les Durance, France..
    Croci, G.
    Ist Sci & Tecnol Plasmi, Via Cozzi 53, Milan, Italy..
    Dworaka, D.
    Polish Acad Sci, Inst Nucl Phys, Radzikowskiego 152, PL-31342 Krakow, Poland..
    Ericsson, Göran
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Applied Nuclear Physics.
    Eriksson, Jacob
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Applied Nuclear Physics.
    Wojcik-Gargula, A.
    Polish Acad Sci, Inst Nucl Phys, Radzikowskiego 152, PL-31342 Krakow, Poland..
    Hjalmarsson, Anders
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Applied Nuclear Physics.
    Jardin, A.
    Polish Acad Sci, Inst Nucl Phys, Radzikowskiego 152, PL-31342 Krakow, Poland..
    Kantor, R.
    Polish Acad Sci, Inst Nucl Phys, Radzikowskiego 152, PL-31342 Krakow, Poland..
    Kovalev, A.
    ITER Org, Route Vinon Sur Verdon,CS 90 046, F-13067 St Paul Les Durance, France..
    Krol, K.
    Polish Acad Sci, Inst Nucl Phys, Radzikowskiego 152, PL-31342 Krakow, Poland..
    Kulinska, A.
    Polish Acad Sci, Inst Nucl Phys, Radzikowskiego 152, PL-31342 Krakow, Poland..
    Kurowski, A.
    Polish Acad Sci, Inst Nucl Phys, Radzikowskiego 152, PL-31342 Krakow, Poland..
    Mariano, G.
    ITER Org, Route Vinon Sur Verdon,CS 90 046, F-13067 St Paul Les Durance, France..
    Mehrara, R.
    Polish Acad Sci, Inst Nucl Phys, Radzikowskiego 152, PL-31342 Krakow, Poland..
    Morawski, D.
    Polish Acad Sci, Inst Nucl Phys, Radzikowskiego 152, PL-31342 Krakow, Poland..
    Rebai, M.
    Ist Sci & Tecnol Plasmi, Via Cozzi 53, Milan, Italy..
    Scholz, M.
    Polish Acad Sci, Inst Nucl Phys, Radzikowskiego 152, PL-31342 Krakow, Poland..
    Scioscioli, F.
    Ist Sci & Tecnol Plasmi, Via Cozzi 53, Milan, Italy..
    Tardocchi, M.
    Ist Sci & Tecnol Plasmi, Via Cozzi 53, Milan, Italy..
    Tracz, G.
    Polish Acad Sci, Inst Nucl Phys, Radzikowskiego 152, PL-31342 Krakow, Poland..
    Turzanski, M.
    Polish Acad Sci, Inst Nucl Phys, Radzikowskiego 152, PL-31342 Krakow, Poland..
    Wiacek, U.
    Polish Acad Sci, Inst Nucl Phys, Radzikowskiego 152, PL-31342 Krakow, Poland..
    Development and performance of the thin-foil proton recoil spectrometer for ITER plasma diagnostics2025In: Fusion engineering and design, ISSN 0920-3796, E-ISSN 1873-7196, Vol. 219, article id 115263Article in journal (Refereed)
    Abstract [en]

    High Resolution Neutron Spectrometer (HRNS) is one of the essential plasma diagnostics of ITER, whose operational role is the neutronic measurement of the nt/nd ratio in a plasma core. Coexisting with the other ITER diagnostics makes it a powerful tool for efficient and precise plasma diagnostics. The main goal of this work is to present the operating principles and key challenges associated with the High Resolution Neutron Spectrometer in ITER, with a particular focus on the Thin-Foil Proton Recoil (TPR) Spectrometer. The complexity of ITER tokamak brings with it many variables that had not been considered of primary importance until now, such as the magnetic field or high temperature in the detector region.

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  • Silva, Luis
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström.
    Ali, Sajid
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Physical Chemistry.
    Gedda, Lars
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Physical Chemistry.
    Agmo Hernández, Víctor
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry.
    Edwards, Katarina
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Physical Chemistry.
    Development and in vitro evaluation of lipodisks optimized for co-delivery of chemotherapeutic drugs and membranolytic anticancer peptides2025In: Journal of Colloid and Interface Science, ISSN 0021-9797, E-ISSN 1095-7103, Vol. 699, article id 138173Article in journal (Refereed)
    Abstract [en]

    Polyethylene glycol (PEG)-stabilized lipodisks constitute a novel and promising class of drug nanocarriers. Their non-spherical shape, small size and deformable morphology confer advantageous features in terms of blood circulation time, biodistribution, tumour penetration and immunological behaviour. In this study, we explore the potential and conditions for using lipodisks for the co-delivery of the membranolytic anticancer peptide melittin and the chemotherapeutic agents doxorubicin (DOX) or SN-38. To this end we prepare lipodisks loaded with DOX or SN-38 alone, as well as lipodisks dually loaded with DOX or SN-38 and melittin. We investigate how variations in the lipodisk lipid composition affects the disk's drug loading capacity, and identify factors that have an important influence on the retention of the anticancer agents in the disks. Additionally, we conduct cell studies to assess and compare the in vitro cytotoxic effects of the mono and dually drug-loaded lipodisks. These studies include experiments designed to explore possible synergistic effects obtained by combining DOX or SN-38 with melittin in the same carrier. Our results indicate that clear synergistic effects can be obtained by co-delivery of SN-38 and melittin (combination index (CI) <= 0.52), while the benefits achieved by combining doxorubicin and melittin in a common lipodisk carrier are more modest (CI <= 0.95). In conclusion, our study highlights the potential of PEG-stabilized lipodisks as effective nanocarriers for the co-delivery of membranolytic peptides and chemotherapeutic agents. The overall findings underscore the versatility and promise of lipodisks in drug delivery applications.

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  • Lindblad, Marie
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Plastic Surgery. Uppsala Univ Hosp, Burn Ctr, Dept Plast & Maxillofacial Surg, Uppsala, Sweden..
    Huss, Fredrik
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Plastic Surgery. Uppsala Univ Hosp, Burn Ctr, Dept Plast & Maxillofacial Surg, Uppsala, Sweden..
    Tano, Eva
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Microbiology. Uppsala Univ Hosp, Dept Clin Microbiol, Uppsala, Sweden..
    Lytsy, Birgitta
    Karolinska Inst, Dept Lab Med, Div Clin Microbiol, Stockholm, Sweden..
    Sütterlin, Susanne
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Paediatric Inflammation, Metabolism and Child Health Research. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, International Child Health and Nutrition. Uppsala Univ Hosp, Childrens Hosp, Dept Paediat Emergency & Infect Dis, Uppsala, Sweden..
    Preventing outbreaks in burn units: the role of hygiene compliance and early warning systems2025In: Antimicrobial Resistance and Infection Control, E-ISSN 2047-2994, Vol. 14, no 1, article id 75Article in journal (Refereed)
    Abstract [en]

    Background and objectivesTo analyse observations of staff's hand hygiene, usage of gloves and plastic aprons, and dress code compliance at the Burn Centre, Uppsala University Hospital in Sweden, and to evaluate the association between hygiene non-compliance and outbreak periods. Furthermore, to explore the potential of using routine hygiene observations as an early warning tool for the risk of uncontrolled spread of (multidrug-resistant) bacteria.MethodsDirect observations of the personnel's compliance with hand hygiene, usage of gloves and plastic aprons, and dress code were studied in relation to two A. baumannii outbreaks in 2014 and 2020. Interrupted time series analyses were conducted from 2013 to 2017 and 2018 to 2022 to evaluate outbreak intervention measures. Rolling sums of observed hygiene errors and 90th percentiles were calculated for four-, five-, and six-month periods.ResultsDuring the study, 13,216 direct observations showed hygiene compliance ranging from 70 to 100% per category. Infection control interventions significantly reduced non-compliance after both outbreaks, with sustained improvements for two years following the first outbreak. Rolling four- to six-month sums, using 90th percentile thresholds of seven, nine, and eleven non-compliances predicted A. baumannii outbreaks.ConclusionIn this setting, compliance levels above 97% were consistently observed during outbreak-free periods, suggesting a potential protective effect. Focus on non-compliance as a key metric and rolling sums of non-compliance, may support early detection of increased outbreak risk and guide preventive interventions.

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  • Alexandrou, Christina
    et al.
    Department of Medicine, Huddinge, Karolinska Institutet.
    Lindqvist, Anna-Karin
    Luleå University of Technology, Department of Health, Education and Technology, Health, Medicine and Rehabilitation.
    Wieslander, Hanna
    Department of Medicine, Huddinge, Karolinska Institutet.
    Rutberg, Stina
    Luleå University of Technology, Department of Health, Education and Technology, Health, Medicine and Rehabilitation.
    Unravelling the roadblocks and pathways to adolescents’ physical activity2025In: International Journal of Qualitative Studies on Health and Well-being, ISSN 1748-2623, E-ISSN 1748-2631, Vol. 20, no 1, article id 2524270Article in journal (Refereed)
    Abstract [en]

    Background

    The COVID-19 pandemic negatively affected adolescents’ opportunities for physical activity in many countries.

    Aim

    To explore experiences and opportunities for physical activity among Swedish adolescents with different backgrounds, considering both the impact of the COVID-19 pandemic and broader influencing factors during and after this period.

    Methods

    Data was collected through focus group interviews (n = 13) with 86 students and analysed using content analysis.

    Results

    Although many adolescents managed to remain physically active during the COVID-19 pandemic, socioeconomic differences affected opportunities for participation in organized sports and activities, as well as perceptions of community safety. Findings also highlighted the important role of schools and the influence of gender and performance norms on physical activity, as well as young girls’ desire for “safe spaces” to focus on their training and development.

    Conclusion

    The COVID-19 pandemic disrupted routines, prompting adaptations and exposing various barriers. Social belonging, socioeconomic background, and prevailing norms significantly influenced activity levels, while the balance between independence and safety emerged as a key factor. Moving forward, we recommend investing in community safety, youth sports, and supportive school policies that challenge gender and performance norms, particularly in socioeconomically disadvantaged areas.

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