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  • 1.
    Adamic, M.
    et al.
    Dermatol Ctr Parmova, Ljubljana, Slovenia..
    Pavlovic, M. D.
    Dermatol Ctr Parmova, Ljubljana, Slovenia.;Univ Maribor, Fac Med, SLO-2000 Maribor, Slovenia..
    Rubin, A. Troilius
    Skane Univ Hosp, Ctr Laser & Vasc Anomalies, Dept Dermatol, Malmo, Sweden..
    Palmetun-Ekback, M.
    Orebro University Hospital. Dept Dermatol.
    Boixeda, P.
    Univ Alcala De Henares, Ramon & Cajal Hosp, Dept Dermatol, Laser Serv, Madrid, Spain..
    Guidelines of care for vascular lasers and intense pulse light sources from the European Society for Laser Dermatology2015In: Journal of the European Academy of Dermatology and Venereology, ISSN 0926-9959, E-ISSN 1468-3083, Vol. 29, no 9, 1661-1678 p.Article in journal (Refereed)
    Abstract [en]

    AimLasers and non-coherent intense pulse light sources (IPLS) are based on the principle of selective photothermolysis and can be used for the treatment of many vascular skin lesions. A variety of lasers has been developed for the treatment of congenital and acquired vascular lesions which incorporate these concepts into their design. Although laser and light sources are very popular due to their non-invasive nature, caution should be considered by practitioners and patients to avoid permanent side-effects. The aim of these guidelines is to give evidence-based recommendations for the use of lasers and IPLS in the treatment of vascular lesions. MethodsThese guidelines were produced by a Consensus Panel made up of experts in the field of vascular laser surgery under the auspices of the European Society of Laser Dermatology. Recommendations on the use of vascular lasers and IPLS were made based on the quality of evidence for efficacy, safety, tolerability, cosmetic outcome, patient satisfaction/preference and, where appropriate, on the experts' opinion. The recommendations of these guidelines are graded according to the American College of Chest Physicians Task Force recommendations on Grading Strength of Recommendations and Quality of Evidence in Clinical Guidelines. ResultsLasers and IPLS are very useful and sometimes the only available method to treat various vascular lesions. It is of a paramount importance that the type of laser or IPLS and their specific parameters are adapted to the indication but also that the treating physician is familiar with the device to be used. The crucial issue in treating vascular lesions is to recognize the immediate end-point after laser treatment. This is the single most important factor to ensure both the efficacy of the treatment and avoidance of serious side-effects.

  • 2.
    Alaish, Ram
    et al.
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine.
    Lundgren, David
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine.
    Suhr, Ole B.
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine.
    Werner, Mårten
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine.
    Karling, Pontus
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine.
    Safety of azathioprine and 6-mercaptopurine in patients with inflammatory bowel disease naive to thiopurine treatment2017In: International journal of clinical pharmacology and therapeutics, ISSN 0946-1965, Vol. 55, no 7, 594-600 p.Article in journal (Refereed)
    Abstract [en]

    Objectives: To determine if 6-mercaptopurine (MP) is better tolerated than azathioprine (AZA) as the initial thiopurine treatment in patients suffering from inflammatory bowel disease (IBD). Switching patients with IBD from AZA to MP is advocated in patients intolerant to AZA. However, no study has determined if MP is more suited than AZA as a first-line treatment for patients who are naive to thiopurine treatment. Study: The tolerance of AZA and MP treatments in clinical practice was retrospectively evaluated from start to 12 months after initiating treatment in 113 patients with IBD who were all naive to thiopurines (82 patients treated with AZA and 31 patients with MP). Results: 65% of the patients treated with AZA and 61% of the patients treated with MP tolerated their treatment during 12 months (i.e., no group difference, p = 0.742). No difference in reported side effects between the two treatments was observed. The mean equivalent initial dose (0.92 vs. 0.61 mg/kg; p < 0.001) and the mean equivalent dose at 12 months (1.98 vs. 1.65 mg/kg; p = 0.014) was significantly higher in the MP group vs. the AZA group. The proportion of patients with.MCV = 7 at 12 months was numerically higher in the MP group than in the AZA group (53% vs. 31%; p = 0.090). Conclusions: In this retrospective observational study, no differences in tolerance or adherence between AZA and MP were observed in patients naive to thiopurines. However, MP treatment was at a higher equivalent thiopurine dose than AZA treatment, which tended to be associated with better treatment response.

  • 3.
    Albinsson, Lars
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Public Health and Caring Sciences.
    A Palliative Approach to Dementia Care: Leadership and organisation, existential issues and family support2002Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The main purpose of this thesis was to apply the WHO and NHS palliative care approach to dementia care.

    Thirty-one staff-members in mid-Sweden (studies I and II) and 20 next-of- kin (study IV) were interviewed. In study III, 316 staff-members from dementia care and 121 staff-members from palliative cancer care responded to a questionnaire about family support. The interviews were tape-recorded and analysed with a qualitative phenomenographic (I and II) and a hermeneutic approach (IV). The questionnaires (III) were analysed using qualitative and quantitative content analysis.

    The staff-members stated almost unanimously that daily leadership was lacking, and consequently clear goal formulations and care planning were rare (I). Proper teamwork between the doctor and the staff who worked on a daily basis with the patients was absent (I). With respect to existential issues, education and staff discussions were lacking (II). The staff were at a loss concerning how to deal with these issues. Nevertheless, these issues are central to family-members who have to deal with an existential crisis (IV). Important questions emerged about obligation and guilt, faithfulness, responsibility, and paying back what you once received. Existential isolation could be identified e.g. in the reversal of roles experienced as "being a parent to your parent" and in the burden of "visiting a living dead person".

    There were no routines for bereavement visits. The type of support suggested for dementia family members is partly similar to support in palliative cancer care, but it also differs in other respects such as feelings of guilt because the early signs of the disease are misunderstood, the need for respite because of the long trajectory of dementia diseases, and the occurrence of anticipatory grief because in the late phase family members can no longer make any contact at all with the patient (III).

    A palliative approach can improve the quality of life for the dementia patient and for the family. It can be used as a basis for a clear goal formulation. Some of the suggestions listed in this thesis for improving the quality of care are more a reflection of the need for a change in attitudes rather than the need for substantial budget increases.

  • 4.
    Alexeyev, Oleg A.
    Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
    Bacterial landscape of human skin: seeing the forest for the trees2013In: Experimental dermatology, ISSN 0906-6705, E-ISSN 1600-0625, Vol. 22, no 7, 443-446 p.Article in journal (Refereed)
    Abstract [en]

    Skin harbours large communities of colonizing bacteria. The same bacterial species can exist in different physiological states: viable, dormant, non-viable. Each physiological state can have a different impact on skin health and disease. Various analytical methodologies target different physiological states of bacteria, and this must be borne in mind while interpreting microbiological tests and drawing conclusions about possible cause-effect relationships.

  • 5.
    Alexeyev, Oleg A
    et al.
    Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
    Lundskog, Bertil
    Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
    Ganceviciene, Ruta
    Palmer, Ruth H
    Umeå University, Faculty of Science and Technology, Department of Molecular Biology (Faculty of Science and Technology).
    McDowell, Andrew
    Patrick, Sheila
    Zouboulis, Christos
    Golovleva, Irina
    Umeå University, Faculty of Medicine, Department of Medical Biosciences, Medical and Clinical Genetics.
    Pattern of tissue invasion by Propionibacterium acnes in acne vulgaris2012In: Journal of dermatological science (Amsterdam), ISSN 0923-1811, E-ISSN 1873-569X, Vol. 67, no 1, 63-66 p.Article in journal (Refereed)
  • 6.
    Alexeyev, Oleg A
    et al.
    Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
    Zouboulis, Christos C
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Dermatology and Venerology.
    Shooting at skin propionibacterium acnes: to be or not to be on target2013In: Journal of Investigative Dermatology, ISSN 0022-202X, E-ISSN 1523-1747, Vol. 133, no 9, 2292-2294 p.Article in journal (Refereed)
  • 7. Andersen, Janice
    et al.
    Nordin, Karin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Lifestyle and rehabilitation in long term illness.
    Sandberg, Sverre
    Illness Perception and Psychological Distress in Persons with Porphyria Cutanea Tarda2016In: Acta Dermato-Venereologica, ISSN 0001-5555, E-ISSN 1651-2057, Vol. 96, no 5, 674-678 p.Article in journal (Refereed)
    Abstract [en]

    Porphyria cutanea tarda (PCT) requires long-term treatment and follow-up, although many patients experience life-long remission. The aim of this cross-sectional postal survey was to describe and investigate the association between illness perception, health complaints, self-reported symptoms and distress in persons with PCT. The participants perceived PCT as a chronic condition with high levels of personal and treatment control. Persons who reported active symptoms scored higher on perceived illness threat, total health complaints and psychological distress compared with those in remission or latent phases. However, a higher perception of illness threat and the total burden of health complaints were more closely associated with psychological distress than were perceived PCT symptoms activity. This has implications for clinical consultation; dermatologists should be attentive to symptoms activity, but also recognize that patients in remission with a high perceived illness threat and multiple health complaints might be especially vulnerable to psychological distress with regards to PCT.

  • 8.
    Andersson, Chris D
    et al.
    Linköpings universitetssjukhus, Dermatologi.
    Meding, Birgitta
    Karolinska Institutet, Inst för miljömedicin.
    Stenberg, Berndt
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Dermatology and Venerology.
    Svensson, Åke
    Malmö Allmänna Sjukhus.
    Working with Population to Treat Individuals: A Report from the Swedish Dermato-Epidemiological Network (SweDEN)2012In: Forum for Nordic Dermato-Venereology, ISSN 1402-2915, Vol. 17, no 2, 44-46 p.Article in journal (Refereed)
  • 9.
    Andersson, Nirina
    et al.
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Dermatology and Venerology.
    Boman, Jens
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Dermatology and Venerology.
    Nylander, Elisabet
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Dermatology and Venerology.
    Rectal chlamydia - should screening be recommended in women?2017In: International Journal of STD and AIDS (London), ISSN 0956-4624, E-ISSN 1758-1052, Vol. 28, no 5, 476-479 p.Article in journal (Refereed)
    Abstract [en]

    Chlamydia trachomatis is the most common bacterial sexually transmitted infection in Europe and has large impacts on patients' physical and emotional health. Unidentified asymptomatic rectal Chlamydia trachomatis could be a partial explanation for the high Chlamydia trachomatis prevalence. In this study, we evaluated rectal Chlamydia trachomatis testing in relation to symptoms and sexual habits in women and men who have sex with men. Rectal Chlamydia trachomatis prevalence was 9.1% in women and 0.9% in men who have sex with men. None of the patients reported any rectal symptoms; 59.0% of the women with a rectal Chlamydia trachomatis infection denied anal intercourse and 18.8% did not have a urogenital infection; 9.4% did neither have a urogenital infection nor reported anal sex. We suggest that rectal sampling should be considered in women visiting sexually transmitted infection clinics regardless of rectal symptoms and irrespective of anal intercourse, since our data suggest that several cases of rectal Chlamydia trachomatis otherwise would be missed, thus enabling further disease transmission.

  • 10.
    Andersson, Rolf
    et al.
    Linköping University, Department of Medical and Health Sciences, Pharmacology. Linköping University, Faculty of Health Sciences.
    Quirk, Chris
    Royal Perth Hospital, WA Australien.
    Sullivan, John
    Liverpool Hospital, NSW Australien.
    Anderson, Chris
    Linköping University, Department of Clinical and Experimental Medicine, Dermatology and Venerology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Medicine, Department of Dermatology and Venerology in Östergötland.
    Cutaneous manifestations of internal disease2008In: Drug Discovery Today : Disease Mechanisms, ISSN 1740-6765, E-ISSN 1740-6765, Vol. 5, no 1, e113-e123 p.Article in journal (Refereed)
    Abstract [en]

    The skin mirrors the individual's well being. Visible for both the patient and the attending physician, it can be a source of information for the diagnosis of multi-system diseases and diseases of internal organs. Therapy is usually directed at the primary disease. Pharmaco-therapeutic options for internal diseases are at present not always optimal and specific management of side effects of drugs with vital indication may be necessary. Better understanding of the mechanisms of the cutaneous manifestations may help develop more efficacious, better tolerated therapy and improve the patient's situation.

  • 11. Andre, M
    et al.
    Odenholt, I
    Schwan, Åke
    Axelsson, Inge
    Mid Sweden University, Faculty of Human Sciences, Department of Health Sciences.
    Upper respiratory tract infections in general practice:: Diagnosis, antibiotic prescribing, duration of symptoms and use of diagnostic tests.2002In: Scandinavian Journal of Infectious Diseases, ISSN 0036-5548, Vol. 34, no 12, 880-886 p.Article in journal (Refereed)
    Abstract [en]

    A diagnosis/antibiotic prescribing study was performed in 5 counties in Sweden for 1 week in November 2000. As part of this study, the characteristics and clinical management of patients with upper respiratory tract infections (n = 2899) in primary care were analyzed. Almost half of the patients were aged < 15 y and one-fifth of the patients consulted out of hours. Of all patients seeking primary care for upper respiratory tract infections, 56.0% were prescribed an antibiotic. Almost all patients who were given the diagnoses streptococcal tonsillitis, acute otitis media or acute sinusitis were prescribed antibiotics, compared to 10% of patients with common cold or acute pharyngitis. The most frequently prescribed antibiotic was penicillin V (79.2%) and this was even more pronounced out of hours, when the diagnoses otitis media and streptococcal tonsillitis were more frequently used. In patients with common cold and acute pharyngitis, the percentage who received antibiotics increased with increasing length of symptoms and increasing CRP levels. In patients with acute pharyngitis or streptococcal tonsillitis, antibiotics were prescribed less frequently provided streptococcal tests were performed. The management of patients with upper respiratory tract infections in general practice seems to be in good agreement with current Swedish guidelines. However, the study indicates some areas for improvement. The diagnosis of acute sinusitis seems to have been overestimated and used only to justify antibiotic treatment.

  • 12. Andre, Malin
    et al.
    Molstad, Sigvard
    Stålsby Lundborg, Cecilia
    Odenholt, Inga
    Axelsson, Inge
    Mid Sweden University, Faculty of Human Sciences, Department of Health Sciences.
    Management of urinary tract infections in primary care:: a repeated 1-week diagnosis-prescribing study in five counties in Sweden in 2000 and 2002.2004In: Scandinavian Journal of Infectious Diseases, ISSN 0036-5548, Vol. 36, no 2, 134-138 p.Article in journal (Refereed)
    Abstract [en]

    A diagnosis-antibiotic prescribing study was performed in 5 counties in Sweden during 1 week in November in the y 2000 and 2002, respectively. As part of the study, the characteristics and clinical management of patients who received diagnoses of urinary tract infections (UTIs) (n = 1564) in primary care, were analysed. 85% of the visits were by women, and 74% of all consultations were diagnosed as lower UTIs. One or more diagnostic tests were performed in 98% of the women with suspected lower or recurrent UTIs and 95% were prescribed an antibiotic. The most commonly prescribed antibiotics for lower UTIs were trimethoprim followed by pivmecillinam and a quinolone. The study indicated a change in antibiotic prescribing with improved adherence to the national recommendations. There was an increase of prescribed nitrofurantoin and a decrease of prescribed quinolones to women with lower UTIs between the studied y. Furthermore, 3-d treatment with trimethoprim increased although the prescribed duration was mostly 7 d. In contrast to the guidelines, few urine cultures were performed. The study highlights the necessity of updating the guidelines for the management of lower UTIs in general practice.

  • 13. André, Malin
    et al.
    Eriksson, Margareta
    Möstad, Sigvard
    Stålsby Lundborg, Cecilia
    Jacobsson, Anders
    Odenholt, Inga
    Axelsson, Inge
    Mid Sweden University, Faculty of Human Sciences, Department of Health Sciences.
    Runehagen, Arne
    Schwan, Åke
    The management of infections in children in general practice in Sweden.: a repeated 1-week diagnosis-prescribing study in 5 counties in 2000 and 2002.2005In: The Journal of Infectious Diseases, ISSN 0022-1899, Vol. 37, no 11-12, 863-869 p.Article in journal (Refereed)
    Abstract [en]

    A diagnosis-prescribing study was performed in 5 Swedish counties during 1 week in November in 2000 and repeated in 2002. The aim of the present study was to analyse data for children 0-15y of age who consulted a general practitioner with symptoms of an infection. During the 2 weeks studied, 4049 children were consulted. Respiratory tract infections (RTI) were the predominant diagnoses, above all among the youngest children, while the proportion of urinary tract infections and skin infections increased with increasing age. Between the y 2000 and 2002, the proportion of children allocated the diagnosis streptococcal tonsillitis and pneumonia decreased (p<0.01 and p<0.001, respectively) while the proportion of common cold increased (p<0.001). Antibiotic prescribing decreased from 55% to 48% (p<0.001) for respiratory infections between the years studied. The only significant changes in type of antibiotics prescribed were the increase of isoxazolylpenicillins (p<0.001) used for skin infection and the decrease of macrolides (p=0.001). A diagnostic test was used in more than half of the consultations. Of children allocated a RTI diagnosis, 36% were prescribed antibiotics when a C-reactive protein test was performed compared to 58% in those not tested. Further studies are needed in general practice to determine the optimal use of near-patient tests in children with RTI.

  • 14. André, Malin
    et al.
    Schwan, Åke
    Odenholt, Inga
    Axelsson, Inge
    Mid Sweden University, Faculty of Human Sciences, Department of Health Sciences.
    The use of CRP tests in patients with respiratory tract infections in primary care in Sweden care can be questioned.2004In: Scandinavian Journal of Infectious Diseases, ISSN 0036-5548, Vol. 36, no 3, 192-197 p.Article in journal (Refereed)
    Abstract [en]

    A diagnosis-antibiotic prescribing study was performed in 5 counties in Sweden during 1 week in November in 2000 and 2002 respectively. As a part of the study, the use and results of C-reactive protein (CRP) tests in relation to duration of symptoms and antibiotic prescribing in 6778 patients assigned a diagnosis of respiratory tract infections were analysed. In almost half (42%) of the patients, a CRP test was performed. The majority of CRP tests (69%) were performed in patients assigned diagnosis upper respiratory tract infection, where the test is not recommended. Overall, there was a minor decrease in antibiotic prescribing when CRP was used (41%), in comparison to 44% of the patients where no CRP was performed (p < 0.01). Patients assigned diagnoses implying a bacterial aetiology were prescribed antibiotics irrespective of result of CRP or length of symptoms before consultation. For patients assigned viral diagnoses, antibiotic prescribing increased with increasing duration of symptoms and increasing value of CRP. The use of CRP decreased antibiotic prescribing in patients assigned to viral diagnoses and with longstanding symptoms (p < 0.001). However, 59% of the patients assigned viral diagnoses with CRP > or = 25 received antibiotics, which seems to indicate a misinterpretation of CRP and a non-optimal use of antibiotics.

  • 15.
    Aneblom, Gunilla
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.
    The Emergency Contraceptive Pill – a Second Chance: Knowledge, Attitudes and Experiences Among Users and Providers2003Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The overall aim of this thesis was to study knowledge, attitudes and experience of emergency contraceptive pills among women and providers.

    Both quantitative and qualitative methods were used. Focus-group interviews were conducted with teenage-girls (I) and with women who had purchased ECP without prescription (IV). Self-administered waiting-room questionnaires were administered to women presenting for induced abortion in three large hospitals (II, III), and after the deregulation of ECP, a postal questionnaire was sent to pharmacy staff and nurse-midwives in three counties in mid-Sweden (V).

    Overall, women showed high basic awareness of ECP although specific knowledge such as the level of effectiveness, time-frames and how the method works was lacking. Approval of the method was high and most women were positive to use the method if they needed. Contradictory views as to whether ECP undermines contraceptive behavior were expressed. As many as 43% of women requesting induced abortion had a history of one or more previous abortions. Among the abortion applicants, one out of five, 22%, had previously used ECP and 3% had used it to prevent the current pregnancy. Media and friends were the two most common sources of information on ECP. Half of the women, 52%, were positive to having ECP prescription-free. Those women who had purchased ECP in a pharmacy without prescription, appreciated this possibility, and the major benefits expressed were time saving aspects. No severe side-effects were reported. The women's experiences of interaction with pharmacy staff were both positive and negative. The importance of up-to-date information about ECP and the OTC-availability from the health care providers was emphasized. Both pharmacy staff and nurse-midwives had positive attitudes towards ECP and the OTC availability. Of pharmacy staff, 38% reported that they referred women to nurse-midwives/gynecologists for further counseling and follow-ups. The need for increased communication and collaboration between pharmacies and local family planning clinics was reported by both study groups with suggestions of regular meetings for information and discussions.

    The results suggest that ECP is still underused and that more factual information is needed before the method is becoming a known, accepted and integrated back-up method to the existing family planning repertoire. Longitudinal research to assess the long-term effects of ECP is needed.

  • 16. Anonym (I.Ax.),
    Två fall av letala neonatala GBS-infektioner [Two cases of lethal neonatal GBS infections].2003Other (Other academic)
  • 17.
    Arrelöv, Britt
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Towards Understanding of Determinants of Physicians’ Sick-listing Practice and their Interrelations: A Population-based Epidemiological Study2003Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Physicians are supposed to act as sick-listing experts and they possess a role as gate-keepers to the social insurance system. Earlier studies have demonstrated variation between physicians and physician categories regarding sick-listing practice. In addition to the patient's disease and its severity, a number of other factors may be expected to influence sick-listing practice. Most earlier studies have focused on the patient's disease and his or her work place as cause for sickness absence.

    The aims of this study were to analyse variation of sick-listing practice between physician categories and the influence of physician characteristics on sick-listing practice, the influence of structure, organisation and remuneration of health care on physician sick-listing practice, the influence of local structural factors in the community, and the influence of a legislative change on physician sick-listing practice.

    The study was conducted as a cross-sectional epidemiological study of 57563 doctors’ certificates for sickness absence, received by 28 local social insurance offices in eight Swedish counties, during four months in 1995 and two months in 1996.

    Patient age, sex, and diagnostic group, issuing physician category, presence of a hospital in the municipality, municipality population size and county were all significantly and independently correlated to number of net days of sick-listing. Physician characteristics, such as age, sex and degree of specialisation were all associated with number of net days of sick-listing. Physicians working in general practice issued significantly shorter periods of sick-listing than the other physician categories. Reimbursement of general practice and participation in financial co-operation with social insurance were significantly correlated to length of sickness episode issued by general practitioners. A legislative change performed during the study period was associated with small effects in sick-listing practice.

    In conclusion, a number of factors other than disease and disease severity and other patient and physician linked factors were found to influence the variation of sick-listing practice. It appears that the closer the influencing factor was to the place were the decision was taken, i.e., the patient-physician consultation, the higher the impact on the decision appeared to be.

  • 18. Aushev, M.
    et al.
    Mussolino, C.
    Cathomen, T.
    Törmä, Hans
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Dermatology and Venereology.
    Reichelt, J.
    Molecular surgery for epidermolysis bullosa simplex2014In: British Journal of Dermatology, ISSN 0007-0963, E-ISSN 1365-2133, Vol. 170, no 4, E35-E35 p.Article in journal (Other academic)
  • 19.
    Axelsson, Inge
    Mid Sweden University, Faculty of Human Sciences, Department of Health Sciences.
    Acute otitis media in children: to treat or not to treat?2000In: Paediatric pulmonology and allergology, ISSN 1392-5261, Vol. 3, no 3, 1022-1032 p.Article in journal (Other academic)
    Abstract [en]

    Every day millions of children world-wide take antibiotics against acute otitis media despite the fact that this treatment has not been shown to benefit the otherwise healthy, average AOM patient. Treatment differs greatly between similar, developed countries. These differences do not seem to be based on rational causes but on differences in mentality and culture. An adoptions of Dutch guidelines for AOM in the USA should result in 400.000 fewer US children on antibiotics during one average day! The incidence of severe complications (mastoiditis, meningitis) must be carefully monitored but there is no evidence that these complications are more common in the Netherlands than in the USA. The number of patients who die due to bacteria made antibiotic-resistant by overuse of antibiotics when treating AOM in children is unknown, but is most probably significant (this is never included in "good versus harm" calculations). We know little about what treatment is best for children suffering from AOM in poor countries, but it is probably wise to be more aggressive there and to adapt a freer usage of antibiotics than is advisable in rich countries.

  • 20.
    Axelsson, Inge
    Mid Sweden University, Faculty of Human Sciences, Department of Health Sciences.
    Advances in airway infections. 1. Pneumonia in children: systematic review. 2. Acute otitis media in children: systematic review.2004Other (Other scientific)
    Abstract [en]

    Peer reviewed. Also published in Hungarian (translated by Tamas Nyeste) and Swedish (translated by I. Axelsson).

  • 21.
    Axelsson, Inge
    Mid Sweden University, Faculty of Human Sciences, Department of Health Sciences.
    Antibiotika ökar risken för hemolytiskt uremiskt syndrom: Escherichia coli O157:H72000In: Läkartidningen, ISSN 0023-7205, Vol. 97, no 25, 3060-3060 p.Article in journal (Other scientific)
  • 22.
    Axelsson, Inge
    Lunds universitet.
    Biology of corneal and skeletal proteoglycans1978In: Biochimie des tissus conjonctifs normaux et pathologiques : Biochemistry of normal and pathological connective tissues / 6th Colloquium of the Federation of European connective tissue clubs, Faculté de médecine, Université Paris Val-de Marne Créteil 28-30 août 1978; publ. sous la direction de A.-M. Robert et L. Robert, 1978, , 385 p.Conference paper (Refereed)
  • 23.
    Axelsson, Inge
    Lunds universitet.
    Characterization of proteins and other macromolecules by agarose gel chromatography1978In: Journal of Chromatography, ISSN 0021-9673, Vol. 152, no 1, 21-32 p.Article in journal (Refereed)
  • 24.
    Axelsson, Inge
    Mid Sweden University, Faculty of Human Sciences, Department of Health Sciences.
    Clinical evidence, Cochrane och PubMed (Compendium, 18 pp.).2001Other (Other scientific)
  • 25.
    axelsson, Inge
    Mid Sweden University, Faculty of Human Sciences, Department of Health Sciences.
    Cochrane-översikt om att förebygga navelinfektioner: Antiseptisk lösning är onödig i i-länder men livräddande i u-länder; evidensbaserad medicin2002In: Läkartidningen, ISSN 0023-7205, Vol. 99, no 14, 1563-1566 p.Article in journal (Refereed)
    Abstract [en]

    One million newborn infants die every year by bacterial infections, which often have entered the body via the umbilicus. A Cochrane systematic review on "Topical umbilical cord care at birth" by J Zupan and P Garner is reviewed. Zupan and Garner conclude that simply to keep the umbilical cord dry and clean is sufficient for healthy, term neonates in rich countries; disinfectants do not offer any advantage. However, cleaning the umbilical cord with disinfectants may reduce the risk of serious bacterial infections in babies in poor countries or in neonatal wards. Observational studies in poor countries indicate that the life of numerous infants can be saved if pregnant women are vaccinated against tetanus and disinfectants are substituted for harmful cord care traditions. This Cochrane review is credible, but it should be updated and considered tentative since no data on sepsis are included. The search strategy should be better described and observational studies (case control and cohort studies) from poor countries should be included since there are no randomized control trials from these countries.

  • 26.
    Axelsson, Inge
    Mid Sweden University, Faculty of Human Sciences, Department of Health Sciences.
    Evidence-based Child Health: 1. Evidence-Based Medicine: what it is, and what it isn't. 2. Evidence-Based Child Health: what it is, and why it should be used. 3. A brief history of EBM. 2004Other (Other scientific)
  • 27.
    Axelsson, Inge
    Mid Sweden University, Faculty of Human Sciences, Department of Health Sciences.
    Evidence-based child health and epidemiology: glossary. (Peer-reviewed. Also Hungarian version, translated by T Nyeste, and Swedish version, translated by I. Axelsson: Ordlista för evidensbaserad barnmedicin och epidemiologi.)2004Other (Other scientific)
    Abstract [en]

    About 170 entries

  • 28.
    Axelsson, Inge
    Mid Sweden University, Faculty of Human Sciences, Department of Health Sciences.
    Internationell utblick [International review]2004In: Läkare mot kärnvapen, ISSN 1400-2256, no 96, 20-21 p.Article in journal (Other (popular scientific, debate etc.))
  • 29.
    Axelsson, Inge
    Mid Sweden University, Faculty of Human Sciences, Department of Health Sciences.
    Järntillskott till barn medför inte fler infektioner2003In: Läkartidningen, ISSN 0023-7205, Vol. 99, no 11, 926-926 p.Article in journal (Other (popular scientific, debate etc.))
  • 30.
    Axelsson, Inge
    Mid Sweden University, Faculty of Human Sciences, Department of Health Sciences.
    Kan antibiotika öka risken för HUS?: Motstridiga svar i metaanalys2002In: Läkartidningen, ISSN 0023-7205, no 44, 4383-4383 p.Article in journal (Other scientific)
  • 31.
    Axelsson, Inge
    Lunds universitet.
    Keratan sulfate proteoglycans.1977Doctoral thesis, monograph (Other academic)
    Abstract [en]

    Summary of PhD thesis in biochemistry (physiological chemistry). (The 6 papers were cited 628 times 1974-2004.)

  • 32.
    Axelsson, Inge
    Mid Sweden University, Faculty of Human Sciences, Department of Health Sciences.
    Kliniska tecken på appendicitis acuta: CRP eller LPK förhöjt hos alla vuxna och hos de flesta barn2001In: Läkartidningen, ISSN 0023-7205, Vol. 98, no 36, 3808-3808 p.Article in journal (Other scientific)
  • 33.
    Axelsson, Inge
    Mid Sweden University, Faculty of Human Sciences, Department of Health Sciences.
    Krupp (pseudokrupp, falsk krupp) [Clinical practice guidelines for croup; peer-reviewed]. 2001Other (Other scientific)
    Abstract [sv]

    b) Printed book: p. 23-26 i Axelsson I et al., Lungsjukdomar - Öppen vård.

  • 34.
    Axelsson, Inge
    Mid Sweden University, Faculty of Human Sciences, Department of Health Sciences.
    Medicina basada en la evidencia en la práctica: tratar o no tratar la otitis media? [Evidence-based medicine in practice: to treat or not to treat otitis media?]1999In: Pediatría Atención Primaria, Vol. 1, no 4, 629-637 p.Article in journal (Refereed)
    Abstract [en]

    Axelsson I. ; also published electronically: http:// ).

  • 35.
    Axelsson, Inge
    Mid Sweden University, Faculty of Human Sciences, Department of Health Sciences.
    Navelvård [topical umbilical cord care].2002Other (Other scientific)
  • 36.
    Axelsson, Inge
    Mid Sweden University, Faculty of Human Sciences, Department of Health Sciences.
    Paediatric cases 20042004Other (Other scientific)
  • 37.
    Axelsson, Inge
    Mid Sweden University, Faculty of Human Sciences, Department of Health Sciences.
    Paediatric news 20042004Other (Other scientific)
  • 38.
    Axelsson, Inge
    Mid Sweden University, Faculty of Human Sciences, Department of Health Sciences.
    Pneumoni hos barn. [Clinical practice guidelines for pneumonia in children.] a) Electronic version:www.internetmedicin.se, Göteborg 2003; latest update 2004.2003Other (Other scientific)
    Abstract [en]

    b) Printed book: p. 40-46 i Axelsson I et al., Lungsjukdomar - Öppen vård. Göteborg: Internetmedicin.se, 2004.

  • 39.
    Axelsson, Inge
    Mid Sweden University, Faculty of Human Sciences, Department of Health Sciences.
    RS-virusinfektioner hos barn2001Other (Other scientific)
    Abstract [en]

    a) Electronic version: www.internetmedicin.se, Göteborg 2001; latest update in November 2004. b) Printed book: p. 31-35 i Axelsson I et al., Lungsjukdomar - Öppen vård. Internetmedicin.se, 2004.

  • 40.
    Axelsson, Inge
    Mid Sweden University, Faculty of Human Sciences, Department of Health Sciences.
    Sju utvecklingsstörda syskon: Om nyttan med PKU-provet2005In: Läkartidningen, ISSN 0023-7205, Vol. 102, no 20, 1560-1560 p.Article in journal (Other scientific)
  • 41.
    Axelsson, Inge
    Mid Sweden University, Faculty of Human Sciences, Department of Health Sciences.
    Skärpning, JK!2003In: Läkartidningen, ISSN 0023-7205, Vol. 100, no 32-33, 2534-2534 p.Article in journal (Other (popular scientific, debate etc.))
    Abstract [en]

    [Letter about the Thalidomide disaster].

  • 42.
    Axelsson, Inge
    Mid Sweden University, Faculty of Human Sciences, Department of Health Sciences.
    Sluta ge steroider till nyfödda, underburna barn2001In: Läkartidningen, ISSN 0023-7205, Vol. 98, no 40, 4355-4355 p.Article in journal (Other (popular scientific, debate etc.))
  • 43.
    Axelsson, Inge
    Mid Sweden University, Faculty of Human Sciences, Department of Health Sciences.
    Tidig hemgång från BB: Ingen nackdel, ingen fördel2003In: Läkartidningen, ISSN 0023-7205, Vol. 100, no 13, 1127-1127 p.Article in journal (Other scientific)
  • 44.
    Axelsson, Inge
    Mid Sweden University, Faculty of Human Sciences, Department of Health Sciences.
    Tonsillit (faryngo-tonsillit) hos barn [pharyngotonsillitis in children].2002Other (Other scientific)
  • 45.
    Axelsson, Inge
    Mid Sweden University, Faculty of Human Sciences, Department of Health Sciences.
    Vaccinationer, barn2004Other (Other scientific)
  • 46.
    Axelsson, Inge
    et al.
    Lunds universitet.
    Bjelle, Anders
    Proteoglycan structure of bovine articular cartilage: variation with age and in osteoarthrosis1979In: Scandinavian Journal of Rheumatology, ISSN 0300-9742, Vol. 8, no 4, 217-221 p.Article in journal (Refereed)
    Abstract [en]

    Proteoglycan subunits (PGS) were isolated from bovine articular cartilage of calves and from cows, 18 months and 8 years old respectively. From the latter cartilage of osteoarthrotic and of non-osteoarthrotic sites was taken. PGS were characterized by gel-chromatography on Sepharose 2B columns and subjected to digestion with chondroitinase ABC and with papain. The isolated keratan sulphate-protein cores obtained from chondroitinase digestion were characterized on Sepharose 4B and the chondroitin sulphate chains on Sephadex G-200 gels. A larger molecular size of PGS was found in calf cartilage than in the other samples. This was attributed to the larger molecular size of chondroitin, whereas no change was observed in the keratan sulphate-protein cores. No change was observed in molecular size of PGS, isolated chondroitin sulphates or keratan sulphate-protein cores in osteoarthrosis in compariith non-osteoarthrotic cartilage from the same joint or from younger adult animals.

  • 47.
    Axelsson, Inge
    et al.
    Lunds universitet.
    Heinegard, D
    Characterization of keratan sulphate proteoglycans from bovine corneal stroma1978In: Biochemical Journal, ISSN 0264-6021, Vol. 169, no 3, 517-530 p.Article in journal (Refereed)
  • 48.
    Axelsson, Inge
    et al.
    Lunds universitet.
    Heinegård, D.
    Characterization of chondroitin sulfate-rich proteoglycans from bovine corneal stroma.1980In: Experimental Eye Research, ISSN 0014-4835, Vol. 31, 57-66 p.Article in journal (Refereed)
  • 49.
    Axelsson, Inge
    et al.
    Mid Sweden University, Faculty of Human Sciences, Department of Health Sciences.
    Högberg, Cecilia
    Kjellberg, Mattias
    (Pseudo)krupp, luftanfuktning och steroidval2001In: Läkartidningen, ISSN 0023-7205, Vol. 98, no 12, 1432-1432 p.Article in journal (Other academic)
  • 50.
    Axelsson, Inge
    et al.
    Mid Sweden University, Faculty of Human Sciences, Department of Health Sciences.
    Rosen, I A
    Impetigo2003Other (Other scientific)
    Abstract [en]

    Clinical practice guidelines for impetigo

1234567 1 - 50 of 469
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