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  • 1.
    Abrouk, Michael
    et al.
    Institute of Experimental Botany, Centre of the Region Hana for Biotechnological and Agricultural Research, Olomouc, Czech Republic.
    Balcarkova, Barbora
    Institute of Experimental Botany, Centre of the Region Hana for Biotechnological and Agricultural Research, Olomouc, Czech Republic.
    Simkova, Hana
    Institute of Experimental Botany, Centre of the Region Hana for Biotechnological and Agricultural Research, Olomouc, Czech Republic.
    Kominkova, Eva
    Institute of Experimental Botany, Centre of the Region Hana for Biotechnological and Agricultural Research, Olomouc, Czech Republic.
    Martis, Mihaela-Maria
    Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Medicine and Health Sciences. Institute for Bioinformatics and Systems Biology, Helmholtz Center Munich, Neuherberg, Germany.
    Jakobson, Irena
    Department of Gene Technology, Tallinn University of Technology, Akadeemia tee 15, Tallinn 19086, Estonia.
    Timofejeva, Ljudmilla
    Department of Gene Technology, Tallinn University of Technology, Akadeemia tee 15, Tallinn 19086, Estonia.
    Rey, Elodie
    Institute of Experimental Botany, Centre of the Region Hana for Biotechnological and Agricultural Research, Olomouc, Czech Republic.
    Vrana, Jan
    Institute of Experimental Botany, Centre of the Region Hana for Biotechnological and Agricultural Research, Olomouc, Czech Republic.
    Kilian, Andrzej
    Diversity Arrays Technology Pty Ltd, Yarralumla, ACT2600, Australia.
    Järve, Kadri
    Department of Gene Technology, Tallinn University of Technology, Akadeemia tee 15, Tallinn 19086, Estonia.
    Dolezel, Jaroslav
    Institute of Experimental Botany, Centre of the Region Hana for Biotechnological and Agricultural Research, Olomouc, Czech Republic.
    Valarik, Miroslav
    Institute of Experimental Botany, Centre of the Region Hana for Biotechnological and Agricultural Research, Olomouc, Czech Republic.
    The in silico identification and characterization of a bread wheat/Triticum militinae introgression line: Characterization of alien introgression in wheat2017In: Plant Biotechnology Journal, ISSN 1467-7644, E-ISSN 1467-7652, Vol. 15, no 2, 249-256 p.Article in journal (Refereed)
    Abstract [en]

    The capacity of the bread wheat (Triticum aestivum) genome to tolerate introgression from related genomes can be exploited for wheat improvement. A resistance to powdery mildew expressed by a derivative of the cross bread wheat cv. Tähti ⨯ T. militinae (Tm) is known to be due to the incorporation of a Tm segment into the long arm of chromosome 4A. Here, a newly developed in silico method termed RICh (rearrangement identification and characterization) has been applied to characterize the introgression. A virtual gene order, assembled using the GenomeZipper approach, was obtained for the native copy of chromosome 4A; it incorporated 570 4A DArTseq markers to produce a zipper comprising 2,132 loci. A comparison between the native and introgressed forms of the 4AL chromosome arm showed that the introgressed region is located at the distal part of the arm. The Tm segment, derived from chromosome 7G, harbors 131 homoeologs out of the 357 genes present on the corresponding region of Chinese Spring 4AL. The estimated number of Tm genes transferred along with the disease resistance gene was 169. Characterizing the introgression's position, gene content and internal gene order should facilitate not only gene isolation, but may also be informative with respect to chromatin structure and behavior studies.

  • 2.
    Agnas, Axel Jönses Bernard
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Biology Education Centre.
    Non-Independent Mate Choice in Female Humans (Homo sapiens): Progression to the Field 2016Independent thesis Advanced level (degree of Master (Two Years)), 30 credits / 45 HE creditsStudent thesis
    Abstract [en]

    There is much evidence that mate-choice decisions made by humans are affected by social/contextual information. Women seem to rate men portrayed in a relationship as more desirable than the same men when portrayed as single. Laboratory studies have found evidence suggesting that human mate choice, as in other species, is dependent on the mate choice decisions made by same-sex rivals. Even though non-independent mate choice is an established and well-studied area of mate choice, very few field studies have been performed. This project aims to test whether women’s evaluation of potential mates desirability is dependent/non-independent of same-sex rivals giving the potential mates sexual interest. This is the first field study performed in a modern human’s natural habitat aiming to test for non- independent mate choice in humans.

    No desirability enhancement effect was found. The possibilities that earlier studies have found an effect that is only present in laboratory environments or have measured effects other than non-independent mate choice are discussed. I find differences in experimental design to be the most likely reason why the present study failed to detect the effect found in previous studies. This field study, the first of its sort, has generated important knowledge for future experimenters, where the most important conclusion is that major limitations in humans ability to register and remember there surrounding should be taken in consideration when designing any field study investigating human mate choice. 

  • 3.
    Ahrné, Karin
    et al.
    SLU.
    Bengtsson, Bengt Åke
    Björklund, Jan-Olof
    Cederberg, Björn
    Eliasson, Claes
    Hydén, Nils
    Jonasson, Jan
    Lindeborg, Mats
    Lst Kalmar Län.
    Ohlsson, Anders
    Palmqvist, Göran
    Ryrholm, Nils
    University of Gävle, Faculty of Health and Occupational Studies, Department of Occupational and Public Health Sciences.
    Rödlista över fjärilar Lepidoptera2015In: Rödlistade arter i Sverige 2015 / [ed] Westling, Anna, Uppsala: ArtDatabanken SLU , 2015, 98-112 p.Chapter in book (Other academic)
  • 4.
    Ajawatanawong, Pravech
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Systematic Biology.
    Baldauf, Sandra
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Systematic Biology.
    An automatable method for high throughput analysis of evolutionary patterns in slightly complex indels and its application to the deep phylogeny of Metazoa2014Article in journal (Refereed)
    Abstract [en]

    Insertions/deletions (indels) in protein sequences are potential powerful evolutionary markers. However, these characters have rarely been explored systematically at deep phylogenetic levels. Previous analyses of simple (2-state) clade defining indels (CDIs) in universal eukaryotic proteins found none to support any major animal clade. We hypothesized that CDIs might still be found in the remaining population of indels, which we term complex indels. Here, we propose a method for analyzing the simplest class of complex indels the “slightly complex indels”, and use these to investigate deep branches in animal phylogeny. Complex indels with two states, called bi-state indels, show similar evolutionary patterns to singleton simple indels and confirms that insertion mutations are more common than deletions. Exploration of CDIs in 2- to 9-state complex indels shows strong support for all examined branches of fungi and Archaeplastida. Surprisingly, we also found CDIs supporting major branches in animals, particular in vertebrates. We then expanded the search to non-bilaterial animals (Porifera, Cnidaria and Ctenophora). The phylogenetic tree reconstructed by CDIs places the Ctenophore Mnemiopsis leidyi as the deepest branch of animals with 6 CDIs support. Trichoplax adhaerens is closely related to the Bilateria. Moreover, the indel phylogeny shows Nematostella vectensis and Hydra magnipapillata are paraphyletic group and position of Cnidarian branches seems to be problematic in the indel phylogeny because of homoplasy. This might be solved if we discover CDIs from animal specific proteins, which emerged after the universal orthologous proteins.Evolutionary Patterns in Slightly Complex Protein Insertions/Deletions (Indels) and Their Application to the Study of Deep Phylogeny in Metazoa

  • 5. Alava, Mikko
    et al.
    Ardelius, John
    KTH, School of Computer Science and Communication (CSC), Computational Biology, CB.
    Aurell, Erik
    KTH, School of Computer Science and Communication (CSC), Computational Biology, CB.
    Kaski, P.
    Krishnamurthy, S.
    Orponen, P.
    Seitz, S
    Circumspect descent prevails in solving random constraint satisfaction problems2008In: Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, E-ISSN 1091-6490, Vol. 105, no 40, 15253-15257 p.Article in journal (Refereed)
    Abstract [en]

    We study the performance of stochastic local search algorithms for random instances of the K-satisfiability (K-SAT) problem. We present a stochastic local search algorithm, ChainSAT, which moves in the energy landscape of a problem instance by never going upwards in energy. ChainSAT is a focused algorithm in the sense that it focuses on variables occurring in unsatisfied clauses. We show by extensive numerical investigations that ChainSAT and other focused algorithms solve large K-SAT instances almost surely in linear time, up to high clause-to-variable ratios a; for example, for K = 4 we observe linear-time performance well beyond the recently postulated clustering and condensation transitions in the solution space. The performance of ChainSAT is a surprise given that by design the algorithm gets trapped into the first local energy minimum it encounters, yet no such minima are encountered. We also study the geometry of the solution space as accessed by stochastic local search algorithms.

  • 6. Ali, Imran
    et al.
    Penttinen-Damdimopoulou, Pauliina E
    Mäkelä, Sari I
    Berglund, Marika
    Stenius, Ulla
    Akesson, Agneta
    Håkansson, Helen
    Halldin, Krister
    Institutet för miljömedicin, Karolinska Institutet.
    Estrogen-like effects of cadmium in vivo do not appear to be mediated via the classical estrogen receptor transcriptional pathway.2010In: Journal of Environmental Health Perspectives, ISSN 0091-6765, E-ISSN 1552-9924, Vol. 118, no 10, 1389-94 p.Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Cadmium (Cd), a ubiquitous food contaminant, has been proposed to be an endocrine disruptor by inducing estrogenic responses in vivo. Several in vitro studies suggested that these effects are mediated via estrogen receptors (ERs).

    OBJECTIVE: We performed this study to clarify whether Cd-induced effects in vivo are mediated via classical ER signaling through estrogen responsive element (ERE)-regulated genes or if other signaling pathways are involved.

    METHODS: We investigated the estrogenic effects of cadmium chloride (CdCl2) exposure in vivo by applying the Organisation for Economic Co-operation and Development (OECD) rodent uterotrophic bioassay to transgenic ERE-luciferase reporter mice. Immature female mice were injected subcutaneously with CdCl2 (5, 50, or 500 µg/kg body weight) or with 17α-ethinylestradiol (EE2) on 3 consecutive days. We examined uterine weight and histology, vaginal opening, body and organ weights, Cd tissue retention, activation of mitogen-activated protein kinase (MAPK) pathways, and ERE-dependent luciferase expression.

    RESULTS: CdCl2 increased the height of the uterine luminal epithelium in a dose-dependent manner without increasing the uterine wet weight, altering the timing of vaginal opening, or affecting the luciferase activity in reproductive or nonreproductive organs. However, we observed changes in the phosphorylation of mouse double minute 2 oncoprotein (Mdm2) and extracellular signal-regulated kinase (Erk1/2) in the liver after CdCl2 exposure. As we expected, EE2 advanced vaginal opening and increased uterine epithelial height, uterine wet weight, and luciferase activity in various tissues.

    CONCLUSION: Our data suggest that Cd exposure induces a limited spectrum of estrogenic responses in vivo and that, in certain targets, effects of Cd might not be mediated via classical ER signaling through ERE-regulated genes.

  • 7. Ali, N.
    et al.
    Junaid, M.
    Ahmad, D.
    urRahman, M.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Biology Education Centre.
    Katzenmeier, G.
    Antibacterial and antifungal activity of solvent extracts from Plumeria obtusa Linn2014In: Tropical Biomedicine, ISSN 0127-5720, Vol. 31, no 4, 607-615 p.Article in journal (Refereed)
    Abstract [en]

    Extracts of Plumeria obtusa are widely used in ethnomedicine and have been investigated for a variety of biological activities; however, the antimicrobial activity of P. obtusa flowers is poorly characterized. In this study, the antimicrobial activities of different solvents (petroleum ether, ethyl acetate, chloroform, isobutanol and ethanol) extracts from flowers of P. obtusa were investigated by a disc diffusion method against Gram-positive bacteria, Gram-negative bacteria and a fungus. All extracts exhibited growth inhibition of all microorganisms at variable degrees as measured by relative zones of inhibition, however, the petroleum ether extract was ineffective against Klebsiella pneumonia and ethyl acetate and isobutanol extracts were ineffective against Pseudomonas aeruginosa. The most susceptible Gram-positive bacterium was Bacillus subtilis while the most resistant Gram-positive bacterium was Staphylococcus aureus. Erwinia carotovora was the most susceptible Gram-negative bacterium while P. aeruginosa was highly resistant among the Gram-negative bacteria. In this study, for the first time, we investigated the antimicrobial activity of several different solvent extracts from flowers of P. obtusa against a broad spectrum of human-pathogenic microorganisms. These compounds warrant further investigation by isolation and structural elucidation with the aim to find novel and affordable bioactive compounds for the treatment of infectious diseases.

  • 8.
    Alkaissi, Hammoudi
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Department of Clinical Pathology and Clinical Genetics.
    Ekstrand, Jimmy
    Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Department of Clinical Pathology and Clinical Genetics.
    Jawad, Aksa
    Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Department of Clinical Pathology and Clinical Genetics.
    Nielsen, Jesper Bo
    University of Southern Denmark, Denmark.
    Havarinasab, Said
    Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Department of Clinical Pathology and Clinical Genetics.
    Söderkvist, Peter
    Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Department of Clinical Pathology and Clinical Genetics.
    Hultman, Per
    Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Department of Clinical Pathology and Clinical Genetics.
    Genome-Wide Association Study to Identify Genes Related to Renal Mercury Concentrations in Mice2016In: Journal of Environmental Health Perspectives, ISSN 0091-6765, E-ISSN 1552-9924, Vol. 124, no 7, 920-926 p.Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Following human mercury (Hg) exposure, the metal accumulates in considerable concentrations in kidney, liver, and brain. Although the toxicokinetics of Hg have been studied extensively, factors responsible for interindividual variation in humans are largely unknown. Differences in accumulation of renal Hg between inbred mouse strains suggest a genetic interstrain variation regulating retention or/and excretion of Hg. A. SW, DBA/2 and BALB/C mouse strains accumulate higher amounts of Hg than B10.S.

    OBJECTIVES: We aimed to find candidate genes associated with regulation of renal Hg concentrations.

    METHODS: A. SW, B10.S and their F1 and F2 offspring were exposed for 6 weeks to 2.0 mg Hg/L drinking water. Genotyping with microsatellites was conducted on 84 F2 mice for genome-wide scanning with ion pair reverse-phase high-performance liquid chromatography (IP RP HPLC). Quantitative trait loci (QTL) were established. Denaturing HPLC was used to detect single nucleotide polymorphisms for haplotyping and fine mapping in 184 and 32 F2 mice, respectively. Candidate genes (Pprc1, Btrc and Nfkb2) verified by fine mapping and QTL were further investigated by real-time polymerase chain reaction. Genes enhanced by Pprc1 (Nrf1 and Nrf2) were included for gene expression analysis.

    RESULTS: Renal Hg concentrations differed significantly between A. SW and B10. S mice and between males and females within each strain. QTL analysis showed a peak logarithm of odds ratio score 5.78 on chromosome 19 (p = 0.002). Haplotype and fine mapping associated the Hg accumulation with Pprc1, which encodes PGC-1-related coactivator (PRC), a coactivator for proteins involved in detoxification. Pprc1 and two genes coactivated by Pprc1 (Nrf1 and Nrf2) had significantly lower gene expression in the A. SW strain than in the B10. S strain.

    CONCLUSIONS: This study supports Pprc1 as a key regulator for renal Hg excretion.

  • 9.
    Amalia, Clausson
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Biology Education Centre.
    Hormonet leptin och dess funktioner2014Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 10.
    Andersson, Fredrika
    Karlstad University, Faculty of Social and Life Sciences.
    Barns tankar om den egna kroppen!: Vad vet fyraåringar och sexåringar om sin kropp!2009Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The aim of this research was to investigate the concepts among five and six year old children regarding the human body. Six children were interviewed by means of qualitative interviews. The children's concept regarding the human body differed depending on their age. The six year old children knew more about the body than the four year old children. Spontaneously the children knew we had heart, brain, blood, brain cells, muscles and skeleton

  • 11.
    Andersson, Helene
    et al.
    KTH, School of Electrical Engineering (EES), Signal Processing. University of Twente, Netherlands .
    Van Den Berg, A.
    From LOC to LIC: Using individual cells as experimentation platforms2005In: Nanobiotechnology, ISSN 1551-1286, Vol. 1, no 3, 319-321 p.Article in journal (Refereed)
    Abstract [en]

    There are many efforts today trying to mimic the properties of single cells in order to design chips that are as efficient as cells. However, cells are nature's nanotechnology engineering at the scale of atoms and molecules. Therefore, it might be better to vision a microchip that utilizes a single cell as experimentation platform. A novel, so-called Lab-in-a-Cell (LIC) concept is described, where advantage is taken of micro/nanotechnological tools to enable precise control of the biochemical cellular environment and possibility to analyze the composition of single cells.

  • 12.
    Andersson, Johanna
    et al.
    Linköping University, Department of Social and Welfare Studies, Learning, Aesthetics, Natural science. Linköping University, Faculty of Educational Sciences.
    Tibell, Lena
    Linköping University, Department of Science and Technology, Media and Information Technology. Linköping University, Faculty of Educational Sciences. Linköpings universitet.
    Exploring childrens' views of what's inside the body2012Conference paper (Refereed)
    Abstract [en]

    The importance of living a healthy life in an everyday context is promoted in schools and preschools. The discussion often focuses on what food is healthy, and that one should eat enough but not too much. The connection between food and beverages and their role in the body is seldom discussed. Students’ ideas about how the human body functions have been investigated in several studies but few have focused on young children. In this study, we investigate young children’s conceptions related to this topic and how their ideas develop. Seventy-nine pre- and primary school children, aged 4-11, participated in individual focus interviews wherein the children were asked to draw and explain their understanding. Our results confirm several findings observed by other workers. However, in contrast with earlier studies, 10 of seventeen 4-5 year-old children indicated the stomach, and more than half of those children described how food can be utilized in the body to extract energy. Furthermore, the brain was among the most commonly mentioned organs cross all age groups. Interestingly, the level of expertise varied and did not covariate with age. For example, five of eight of the 4 year-old children draw 5-8 organs, while a single 10 year-old child could only mention three. Similarly, two of thirteen 7-year old children provided an almost completely correct description of the digestive tract and its function, while most of the older children expressed a much less developed understanding. The results reflect the wide range of different conceptual ideas that teachers confront in a day-to-day classroom context.

  • 13.
    Andersson, Johanna
    et al.
    Linköping University, Department of Social and Welfare Studies, Learning, Aesthetics, Natural science. Linköping University, Faculty of Educational Sciences.
    Tibell, Lena A.E.
    Linköping University, Department of Science and Technology, Media and Information Technology. Linköping University, Faculty of Educational Sciences. Linköpings universitet.
    Children's reasoning and representations about living and non-living things2013Conference paper (Refereed)
    Abstract [en]

    Understanding of the concept ‘life’ and what characterise ‘living things’ is important as a foundation for learning in biology. In a more general view, this understanding can make children develop awareness, respect and responsibility for life as members of a society and in decision making for sustainable development. The present pilot study aim to investigate 5-6 year old pre-school children’s reasoning and representations about living and nonliving things. In cognitive developmental research, the concept of life is well investigated but, questions still remain regarding how children reason around and represent these concepts. Previous research has found that children have difficulties in including plants as living things. Moreover, it is found that young children include e.g. the sun, clouds and rocks as living things. The methods that have been used are often quantitative and use picture-cards with different objects for the children to categorize. In the present pilot study a modified methodology was applied. Children’s drawings of what they consider as living and non-living were collected and picture-cards were used as point of departure for reasoning. In interviews the children were encouraged to explain and express their ideas. The drawings and the cards mainly worked as a meaning making tool for the children. Results from the study will be presented and discussed. 

  • 14.
    Andersson, Magnus
    University of Gävle, Faculty of Engineering and Sustainable Development, Department of Electronics, Mathematics and Natural Sciences.
    Bergviksäpplet och dess fruktsättning2014Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Trees of Bergvik apple (Bergviksäpple) planted between 2001 and 2007 have shown varying harvest. This study investigates why some trees gets low or no harvest while others get significantly higher harvest. The aim is to identify some reasons why fruiting differs between the trees and if possible suggest and/or enlighten the tree owners what can be done to improve fruiting. The study includes 25 trees, mostly located in Hälsingland, Sweden. The tree owners have answered two questionnaires, first in the spring with questions regarding flowering and the second in the autumn, regarding harvest. The answers to these questionnaires form the foundation for this work.

    The result of the study reveals differences in harvest. Older trees and/or trees with good vegetative growth have larger harvest while trees with poor growth in some cases didn’t even get flowers. Younger trees with good growth gave good harvest. This concludes that the single most important factor to get good harvest is good vegetative growth.

  • 15.
    Andersson, Niki
    Umeå University, Faculty of Science and Technology, Department of Ecology and Environmental Sciences.
    Biology and biodiversity of tardigrades in the world and in Sweden: Current status and future visions2017Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Tardigrades are small water-dwelling invertebrates that can live almost anywhere in the world. Even though they are well-known our knowledge about them is still scarce. The aim of this study was therefore to explore our current knowledge about tardigrades by: (1) explore their global phylogeny and biogeography based on bioinformatics (2) screen for tardigrades in select locations of northern Sweden and compare with other Swedish locations, and (3) identify at least one tardigrade from northern Sweden and explore the published biomarkers for further identification. The bulk of this thesis was based on evaluation of the Silva database for analyzing SSU (small subunit) and LSU (large subunit) tardigrade sequences and create phylogenetic trees. Some initial lab work was performed using samples of moss and lichen from Piteå, Vindeln and Öland. Results show that only few countries have been explored with regard to tardigrades, and in Sweden more research have been performed in the south compared to the north. The phylogenetic trees give a rough overview of tardigrade relatedness but many of the sequences need to be improved and more sequence work from additional environments is needed. In the lab tardigrades were only found from the Piteå samples, and one of those was identified as Macrobiotus hufelandi, for which a new biomarker was created. Overall, tardigrade research need to continue and expand to other regions in order to understand how these organisms differ between different environments, and more work is needed to ensure higher quality of sequences added to databases.

  • 16.
    Anstrén, Ludwig
    Halmstad University, School of Business, Engineering and Science.
    The Reliability of Cooper ́s Test in Subjects Between 28-60 Years of Age2015Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Background: Maximal oxygen uptake (VO2max) is a determinant of an individual’s ability to handle oxygen during maximal exercise. To measure VO2max expensive equipment and expertise personnel are required. To make the process of measuring VO2max easier, several submaximal and maximal tests have been created in which an estimation of VO2max could be made. Cooper’s 12-minute run (12MR) was created in 1968 and was tested on 115 military men with a mean age of 22 years. Since then the 12MR test has been re- tested and validated towards maximal treadmill tests on several occasions. When an age of 30 years is reached, VO2max starts to decline with 9-10 percent per decade but can be halted by different forms of exercise. With exercise of moderate to high intensity the decline can be halted by almost 50 percent. Objective: To investigate the reliability of estimated VO2max in a test retest scenario of Cooper ́s 12MR on a mixed healthy population between the ages of 28-60. Method: Nine women and five men, healthy subjects with a mean age of 43 ± 8 participated in the present study. A test retest of Cooper ́s 12MR took place with a minimum of seven days between tests. The subjects had to run as many laps as possible on the track during a 12-minute period. Finished laps were then counted and the fraction of the last lap was measured with a measuring wheel and then added to the total distance. To estimate the subjects’ VO2max Cooper ́s table was used. Results: The single measure Intraclass correlation (ICC) that was found, between the estimated VO2max made from the initial test to the retest on Cooper ́s 12MR, was 0.979. ICC showed a small error variance correlation between the tests and was close to the optimal correlation of 1.0. Conclusion: A standardized protocol for performing Cooper ́s 12MR showed good repeatability for estimating VO2max in two separate tests for a mixed population between 28 to 60 years of age. 

  • 17.
    Appel, Madeleine
    University of Gävle, Faculty of Engineering and Sustainable Development, Department of Electronics, Mathematics and Natural Sciences.
    Kulturarvets mosaiklandskap i ny tappning för trädgårdar och balkonger: En litteraturstudie med designförslag som bidrag för bevarandet av mångfalden för solitära bins överlevnad2015Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Abstract. The purpose of this study is to find out what can be done in gardens and balconies for solitary bees survival, species have already been lost or are red-listed because of poor conditions in terms of habitat. What can design-proposals look like for gardens and balconies? What do suitable habitats contain and what do threats look like for solitary bees?The goal with this literature study was to find answers to my questions. Based on facts that emerged from the results, design proposals have been made for gardens and balconies. Increased biotope-surface from ancient times mosaic-landscape can in modern environments like gardens and balconies be designed as non-toxic and flower-rich meadows, flowering border zones, ditches and flower beds, potted plants, flowering trees and shrubs. Solitary bees need shelter, water to drink and food to eat as in nectar and pollen-rich plants. They need flowering plants from early spring to late autumn to survive. It´s important to spread knowledge and understanding how solitary bees live their lives, that people can cooperate to achieve long-term sustainable habitat solutions. Solitary bees need many flowering plant-surfaces that can act as dispersal corridors in to urban environments, where every single square meter flowering-surface is of importance. Solitary bees increase in number with increasing biotope-surfaces which are facts that design proposals are based on. Devastating threats for solitary bees are floral shortage in urban areas, spraying with various poisons, domestic bees spreading diseases, human fear of small insects and altered habitats.

  • 18.
    Ardabili, Sahar
    KTH, School of Biotechnology (BIO), Proteomics and Nanobiotechnology.
    Microfluidic bases sample preparation for blood stream infections2014Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Microfluidics promises to re-shape the current health-care system by transferring diagnostic tools from central laboratories to close vicinity of the patient (point-of-care). One of the most important operational steps in any diagnostic platform is sample preparation, which is the main subject in this thesis. The goal of sample preparation is to isolate targets of interest from their surroundings. The work in this thesis is based on three ways to isolate bacteria:  immune-based isolation, selective cell lysis, size-based separation.

    The first sample-preparation approach uses antibodies against lipopolysaccharides (LPS), which are surface molecules found on all gram-negative bacteria. There are two characteristics that make this surface molecule interesting. First, it is highly abundant: one bacterium has approximately a million LPS molecules on its cell-wall. Second, the molecule has a conserved region within all gram-negative bacteria, so using one affinity molecule to isolate disease-causing gram-negative bacteria is an attractive option, particularly from the point of view of sample preparation. The main challenge, however, is antigen accessibility. To address this, we have developed a treatment protocol that improves the capturing efficiency.

    The strategy behind selective cell lysis takes advantage of the differences between the blood-cell membrane and the bacterial cell-wall. These fundamental differences make it possible to lyse (destroy) blood-cells selectively while keeping the target of interest, here the bacteria, intact and, what is more important alive. Viability plays an important role in determining antibiotic susceptibility.

    Difference in size is another well-used characteristic for sample- separation. Inertial microfluidics can focus size-dependent particle at high flow-rates. Thus, particles of 10 µm diameter were positioned in precise streamlines within a curved channel.  The focused particles can then be collected at defined outlets.  This approach was then used to isolate white blood cells, which account for approximately 1% of the whole blood.  In such a device particles of 2µm diameter (size of bacteria) would not be focused and thereby present at every outlet. To separate bacteria from blood elasto-inertial microfluidics was used. Here, e blood components are diverted to center of the channels while smaller bacteria remain in the side streams and can subsequently be separated.

  • 19.
    Askvärn, Elisabeth
    University of Gävle, Faculty of Engineering and Sustainable Development, Department of Electronics, Mathematics and Natural Sciences.
    Kan växter lindra klimakteriebesvär?: Behandling av vasomotoriska symptom med hjälp av örtmedicin2016Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The aim of this study was to investigate the use of herbal medicine for vasomotor symptoms during menopause. The questions posed were which herbs that were used, what parts of the herbs that were used, and how the plant parts were prepared and utilized. The last question covered how much the plants alleviated the vasomotor symptoms.

    A review of the scientific literature was carried out. In the articles, 20 herbs and plants were used, but only five of them were said to relieve the vasomotor symptoms. The five plants were Actaea racemosa, Angelica sinensis, Ginkgo biloba, Glycine sp. and Pimpinella anisum.  The most commonly used parts of the herbs were the roots, often through extracts that were processed in order to increase the concentration and to transform the plant parts into powder. The powder was then for the most part transformed to tablets and capsules. Sometimes, information was missing, such as the scientific names of the plants, what parts of the plants that were used and how the herbs were prepared and utilized.

    On average, the herbs alleviated the vasomotor symptoms by 60 %. Most of the herbs appeared to relieve mild symptoms more than they alleviated strong symptoms. An exception was P. anisum, which decreased both the amount of and the strength of the flushes by 74 %.

    This literature study shows that there are plants that influence the vasomotor symptoms in a positive direction. At the same time, it shows that the information in the articles is sometimes incomplete and that the scientists do not always study if the herbs can give side effects.

    Herbal medicine could be an alternative for women who, for different reasons, cannot or do not want to take synthetic hormones or other pharmacological medicines. However, in order to make herbal medicine part of the treatment offered by public health care, longitudinal studies that also investigate possible side effects or risks are needed for securing the effect of the herbs on the human body.

  • 20.
    Backius, Helena
    Karlstad University, Faculty of Social and Life Sciences, Department of Biology.
    Förändring av kärlväxters artsammansättning vid återupptagen hävd i skogligt avgränsade ängs- och hagmarker2011Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Old agricultural landscapes house a great biodiversity. To conserve this diversity the European Union award financial support in the form of environmental grants to encourage farmers to maintain pastures and hay meadows using old-fashioned methods. But are the measures effective and do they meet their purpose? The purpose of this study was to re-inventory ten sample plots from 2002 on the farm Brofallet to see how species composition of vascular plants had been affected by the nine seasons of using these old-fashioned methods management. The farm is completely surrounded by forest, isolated from other agricultural land. No significant overall change was observed concerning the composition of vascular plant species favored by traditional management. Qualitative observations, however, showed an increase in some species favored by traditional management. The conclusion is that the five-year commitment that farmers make to receive the environmental grants is not adequate enough to be able to detect changes in total diversity of vascular plants on a farm such as Brofallet, but that changes may occur faster at other levels in the ecosystem. Moreover, a ramification of this study is the idea that even environmental measures and documentation should be characterized by diversity. In summary, small-scale extensive farming may prove to be important in the overall quest for a sustainable society, both to exploit land for food production using extensive farming, and to maintain biodiversity at the landscape level.

  • 21.
    Balck, Marianne
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Biology Education Centre.
    Utgör användning av p-piller ett hot mot livskraftiga grodpopulationer?: Etinylöstradiols och levonorgestrels effekter hos arterna Xenopus leavis, Xenopus tropicalis och Rana temporaria2013Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    En eskalerande minskning hos grodpopulationer och grodarter har skett världen över sedan 1980. Minskningen har påverkats av flera faktorer, bland annat utsläpp av endokrina ämnen till vattendrag. Endokrina ämnen är naturliga och syntetiska hormoner och kemikalier som stör människors och djurs hormonsystem. Syntetiska hormoner finns i p-piller och andra preventivmedel och hormonerna släpps ut i vattendrag via urinen. Det har visats att grodor påverkas av de syntetiska hormonerna etinylestradiol och levonorgestrel som finns i p-piller. Den här litteraturstudien syftar till att undersöka vilka effekter de två hormonerna har på modellarterna Xenopus laevis och Xenopus trolpicalis och på svenska grodarter såsom Rana temporaria. Effekterna är främst förändrad könskvot, med honor i majoritet, samt minskad fertilitet. Fertiliteten försämras genom missbildade könsorgan, genom att äggen mognar långsammare och honor kan bli sterila med avsaknad av äggledare. Hormonexponering kan leda till försenad metamorfos och det kan bli en högre mortalitet hos juvenila grodor. Även hormonuttryck kopplade till reproduktion och fertilitet kan påverkas av hormonexponering. Dock behövs mer forskning, särskilt i fält då mestadels experimentella studier gjorts hittills i laboratorier. Hormonutsläpp är en bidragande faktor till att sex av Sveriges åtta grodarter är rödlistade och i världen handlar det om tusentals arter. Även den så kallade cocktail effekten, det vill säga de effekter flera olika ämnen skapar tillsammans, bör undersökas närmare.

  • 22.
    Balck, Marianne
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Biology Education Centre.
    Phthalates in preschool dust: the relation between phthalates and parameters in the preschool environment2015Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Children are constantly exposed to many chemicals via the products they come in contactwith in their everyday life. One chemical group is phthalates, the most commonly usedplasticisers in the world. Phthalates are used mainly in PVC plastic products like floors, toys,food containers and wallpaper but they are also used in rubber, glue, paint, cables etc. Sincethese chemicals are weakly chemically bound to the PVC they can leak and migrate to the air,food, water and skin. Children are exposed to phthalates mainly through food, but because ofthe hand to mouth behaviour they are also exposed via dust inhalation and dust ingestion.About ten years ago regulations of the most toxic phthalates in toys and child care productswere implemented in the EU and from February 2015 it is a general prohibition for the use ofDEHP (diethylhexyl phthalate), DnBP (di-n-butyl phthalate), DiBP (diisobutyl phthalate) andBBzP (butyl benzyl phthalate). DiNP (diisononyl phthalate) is a relatively new phthalate andit has replaced DEHP to some extent in floors and toys. In phthalate free products DINCH(1,2-cyclohexane dicarboxylic acid diisononyl ester) is one of the plasticizer replacingphthalates. The banned phthalates have been shown to cause adverse effects on reproductionand recent research also investigates links between phthalate exposure and asthma and allergysymptoms in children. More experimental animal studies are needed to further investigate theasthma and allergy correlation.

    In the present project dust samples were collected from 30 preschool indoor environments inthe Stockholm city area to evaluate the levels of the six substances mentioned and thephthalate DEP (diethyl phthalate). The main aim of this thesis project was to search forrelations and links between the phthalate concentrations in dust and parameters from theindoor environment in preschools. Studied parameters are e.g. construction year, floor type,cleaning routines and quantity of toys and furniture made of plastic or foam. The project wascommissioned by the Swedish EPA and performed at the Institute of Environmental Medicine(IMM) at Karolinska Institutet.

    A negative relation was found between dust phthalate (DEHP and DnBP) concentrationand construction year. Also rooms with old PVC floors had higher concentrations of DEHPand DnBP in dust than rooms with new PVC floors. There was also a trend that dust frompreschools with PVC floors had higher DiNP concentration than dust from preschools withother floor types. The preschools that used foam mattresses for resting had higher DiNPconcentrations than those with no foam mattresses. Most preschools had new foammattresses, which could indicate a more common use of DiNP in new mattresses or mattress2covers compared to old mattresses that contains more DEHP. The four Waldorf preschoolsthat participated had lower DiNP dust concentrations than the other preschools, which wasexpected since Waldorf orientation includes using as little plastic material as possible. Norelation was found between the phthalate dust concentrations and the quantity of toys made ofsoft plastic in the sampled area.

    Many preschools had made a plastic inventory where they removed old and soft plastic toysand material. Also many preschools recently replaced old foam mattresses used for resting.This could be due to the big chemical focus in the media and authorities and the brochuresthat have been sent out the last couple of years about what preschool can do to decrease thechemical exposure of children. This interest and awareness seen in the preschools waspositive and hopefully the trend spreads to more preschools. Since children spend a big part oftheir time at preschools it is an important mission for society and the government to decreasethe exposure to hazardous chemicals there. Hopefully what has been done so far is just thebeginning.

  • 23.
    Beckman, Sara
    Mid Sweden University, Faculty of Science, Technology and Media, Department of Science Education and Mathematics.
    Naturen som mötesplats2017Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
  • 24.
    Beijer, Kristina
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Environmental toxicology.
    Jönsson, Maria
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Environmental toxicology.
    Shaik, Siraz
    Behrens, Daphné
    Brunström, Björn
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Environmental toxicology.
    Brandt, Ingvar
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Environmental toxicology.
    Azoles inhibit cytochrome P450 enzymes in rainbow trout involved in biotransformation and steroid hormone synthesis additively2015Manuscript (preprint) (Other academic)
  • 25.
    Beijer, kristina
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Environmental toxicology.
    Shaik, Siraz
    Berndt, Björlenius
    KTH.
    Lindberg, Richard
    Umeå Universitet.
    Brunström, Björn
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Environmental toxicology.
    Brandt, Ingvar
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Environmental toxicology.
    Reduction of pharmaceuticals and other contaminants in sewage treatment effluents by active carbon filtration and ozonation: Evaluation using biomarker responses in fish and chemical analysisManuscript (preprint) (Other academic)
  • 26.
    Benlloch, Reyes
    et al.
    Umeå University, Faculty of Science and Technology, Umeå Plant Science Centre (UPSC).
    Kim, Min Chul
    Division of Applied Life Science (BK21 Program), Plant Molecular Biology and Biotechnology Research Center, Gyeongsang National University, Jinju 660-701, Korea.
    Sayou, Camille
    Thevenon, Emmanuel
    CEA, iRTSV, Laboratoire Physiologie Cellulaire et Végétale, F-38054 Grenoble, France.
    Parcy, Francois
    CEA, iRTSV, Laboratoire Physiologie Cellulaire et Végétale, F-38054 Grenoble, France.
    Nilsson, Ove
    Umeå University, Faculty of Science and Technology, Umeå Plant Science Centre (UPSC).
    Integrating long-day flowering signals: a LEAFY binding site is essential for proper photoperiodic activation of APETALA12011In: The Plant Journal, ISSN 0960-7412, E-ISSN 1365-313X, Vol. 67, no 6, 1094-1102 p.Article in journal (Refereed)
    Abstract [en]

    The transition to flowering in Arabidopsis is characterized by the sharp and localized upregulation of APETALA1 (AP1) transcription in the newly formed floral primordia. Both the flower meristem-identity gene LEAFY (LFY) and the photoperiod pathway involving the FLOWERING LOCUS T (FT) and FD genes contribute to this upregulation. These pathways have been proposed to act independently but their respective contributions and mode of interaction have remained elusive. To address these questions, we studied the AP1 regulatory region. Combining in vitro and in vivo approaches, we identified which of the three putative LFY binding sites present in the AP1 promoter is essential for its activation by LFY. Interestingly, we found that this site is also important for the correct photoperiodic-dependent upregulation of AP1. In contrast, a previously proposed putative FD-binding site appears dispensable and unable to bind FD and we found no evidence for FD binding to other sites in the AP1 promoter, suggesting that the FT/FD-dependent activation of AP1 might be indirect. Altogether, our data give new insight into the interaction between the FT and LFY pathways in the upregulation of AP1 transcription under long-day conditions.

  • 27. Berg, Andreas
    et al.
    Lindblad, Peter
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Molecular Biomimetics.
    Svensson, Bo Håkan
    Cyanobacteria as a source of hydrogen for methane formation2014In: World Journal of Microbiology & Biotechnology, ISSN 0959-3993, E-ISSN 1573-0972, Vol. 30, no 2, 539-545 p.Article in journal (Refereed)
    Abstract [en]

    In a study during the 1970s co-variation of nitrogenase activity and methane formation associated with Sphagnum riparium was observed. This was suggested as evidence for a possible mechanism of hydrogen transfer from cyanobacteria to methanogens. We show experimentally that such a pathway is feasible. In a series of laboratory experiments, using a hydrogenase deficient strain of the heterocystous cyanobacterium Nostoc punctiforme and the hydrogenotrophic methanogen Methanospirillum hungateii in co-cultures, increasing light intensities resulted in elevated nitrogenase activity and methane production. The increase in methane production can be directly deduced from the nitrogenase activity of the N. punctiforme based on hydrogen balance calculations. These experimental results clearly suggest the possible existence of a novel photosynthetically regulated pathway for methane formation.

  • 28.
    Berg, Cecilia
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Environmental Toxicology.
    An Amphibian Model for Studies of Developmental Reproductive Toxicity2012In: Developmental Toxicology: Methods and Protocols / [ed] Craig Harris, Jason M Hansen, Humana Press , 2012, 73-83 p.Chapter in book (Other academic)
  • 29.
    Berg, Cecilia
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Environmental Toxicology.
    Brunström, Björn
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Environmental Toxicology.
    Brandt, Ingvar
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Environmental Toxicology.
    Müllerian Duct Dysgenesis: a common cause for female reproductive disorders2012In: Toxicology Letters, ISSN 0378-4274, E-ISSN 1879-3169, Vol. 211, no suppl., S184- p.Article in journal (Refereed)
  • 30.
    Berg, Cecilia
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Environmental Toxicology.
    Lundstedt-Enkel, KatrinUppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Environmental Toxicology.Malmsten, JonasSLU.Persson, SaraSLU.
    Reproductive Disorders in Baltic Vertebrate Wildlife (BALTREP 2011): What is the status of, and the threats to reproductive health in Baltic region wildlife?2011Conference proceedings (editor) (Other academic)
  • 31.
    Berg, Cecilia
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Environmental Toxicology.
    Säfholm, Moa
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Environmental Toxicology.
    Progestins: potent endocrine disrupters of the female reproductive system2012In: Abstract book: Part 2, 2012, 179-179 p.Conference paper (Refereed)
  • 32.
    Berg, Cecilia
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Environmental Toxicology.
    Säfholm, Moa
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Environmental Toxicology.
    Fick, Jerker
    Umeå universitet.
    Norder, Anna
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Environmental Toxicology.
    Environmental progestin concentrations disrupt oogenesis in amphibians2012In: Abstract book: part 1, 2012Conference paper (Refereed)
  • 33.
    Berg, Cecilia
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Environmental Toxicology.
    Säfholm, Moa
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Environmental Toxicology.
    Jansson, Erika
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Environmental Toxicology.
    Olsson, A. Jan
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Environmental Toxicology.
    Fick, Jerker
    Umeå universitet.
    Brandt, Ingvar
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Environmental Toxicology.
    Combined Exposure to Progestin and Estrogen Mixtures: effects on vitellogenin and hormone receptor mRNA expression2012In: Comparative Biochemistry and Physiology A, ISSN 1095-6433, E-ISSN 1531-4332, Vol. 163, no suppl., S56-S57 p.Article in journal (Refereed)
  • 34.
    Berggren, Åsa
    Karlstad University, Faculty of Health, Science and Technology (starting 2013).
    Predatorinducerad fekunditet hos Daphnia pulex vid simulerade årstidsbundna temperaturvariationer2015Independent thesis Advanced level (degree of Master (One Year)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Female growth, number of eggs and egg growth of Daphnia pulex were studied at four temperatures, 12, 16, 18 and 20°C. I hypothesized that female growth and number of eggs would be lower and the size of the eggs larger in the presence of a predator (kairomones) than in its absence. This effect was expected to be more evident at lower temperatures. I could not find any effect of kairomones on female growth, number of eggs or egg size, although there was a weak tendency for an effect on number of eggs. There was, however, an effect of temperature, regardless of predator treatment (i. e. presence vs absence of kairomones), on number of eggs, where females produced fewer numbers of eggs with increasing temperature. The effect temperature on the number of eggs was not anticipated. Two of the temperatures, 12 and 18°C, were carried out in darkness due to malfunctioning equipment. In addition, for some unknown reason, a high ratio between the number of ephippia and eggs occurred at at16 and 18°C, regardless of predator treatment. These complicating factors (darkness and ephippia) can have had a negative effect on detecting a response by Daphnia to kairomones.

  • 35.
    Berglund, Marie
    Mid Sweden University, Faculty of Science, Technology and Media, Department of Science Education and Mathematics.
    Är ute inne?: 15-åriga elevers uppfattningar om uteskola2016Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 36.
    Berglund, Sara
    Karlstad University, Faculty of Social and Life Sciences.
    Förskolepedagogers tankar om skogen som utbildningsplats2013Independent thesis Advanced level (professional degree), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    This is an interview study with eleven preschool teachers. The purpose with this study has been to find out teachers view on the forest as an educational resource. The result shows that the interviewed consider the forest as an educational resource. With educational resource means that the pedagogs saw the forest as an access in children’s learning process. They use the forest in the learning of science, but also, for example, Swedish and mathematics. Some difficulties were encountered during the interviews; one was the lack of interest and knowledge of science and the forest. The other thing was that many of the children come from war- torn countries which made it difficult to work with the forest as an educational resource. Because these children and their families found the forest as an insecure and dangerous environment.

  • 37.
    Berglund, Åsa
    Umeå University, Faculty of Science and Technology, Department of Ecology and Environmental Sciences.
    Responses to reduced industrial metal emissions: An ecotoxicological study on Pied Flycatcher (Ficedula hypoleuca, Aves)2010Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Metals have been used by humans for thousands of years, and this has resulted in increased concentrations in the biosphere. The environment around point-sources, such as mines and smelters, are of particular concern, as metals may accumulate to high concentrations, and potentially reach levels toxic to the local flora and fauna. This thesis focuses on the effects on pied flycatcher populations of two such point-sources, a lead mine and enrichment plant, and a sulfide ore smelter. Mining activities at the lead mine ceased in 2001 and pied flycatcher populations were assessed before and after the closure. At the sulfide ore smelter, pied flycatchers were studied during the 1980s. Since then, the metal emissions to air from the smelter (e.g. arsenic, cadmium, copper, mercury, lead and zinc) have been greatly reduced (by 93 – 99%).

    Pied flycatchers from these two contaminated environments differed in their responses to reduced atmospheric deposition. At the mine site, nestling responses reflected the reduced atmospheric deposition and less lead accumulated in their tissues. However, lead levels were still high enough to cause negative effects on blood status (δ-aminolevulinic acid dehydratase [ALAD], hemoglobin [Hb], hematocrit [ht], and mean cell hemoglobin concentration) and reproduction (reduced clutch size, increased mortality and reduced breeding success), as was observed when the mine was in operation. Along the pollution gradient away from the smelter, nestling concentrations reflected the metal load in the soil pool, accumulating over time, rather than the atmospheric deposition. This resulted in only a minor response to decreased metal deposition (slightly reduced liver lead concentrations at 3.5 – 90 km from the smelter). This suggests that in environments with highly polluted soils, decreased inputs of atmospheric metal deposition have only minor impacts, and recovery from contamination should not be expected within decades.

    The high metal concentrations in the vicinity of the smelter contributed to poorer blood status (ALAD, Hb and ht), induced oxidative damage and defenses, and decreased reproduction (increased mortality and reduced breeding success). There were only minor improvements in blood and reproductive variables at 3.5 km from the smelter.

  • 38.
    Berglund, Åsa M. M.
    et al.
    Umeå University, Faculty of Science and Technology, Department of Ecology and Environmental Sciences.
    Rainio, Miia J.
    Kanerva, Mirella
    Nikinmaa, Mikko
    Eeva, Tapio
    Antioxidant status in relation to age, condition, reproductive performance and pollution in three passerine species2014In: Journal of Avian Biology, ISSN 0908-8857, E-ISSN 1600-048X, Vol. 45, no 3, 235-246 p.Article in journal (Refereed)
    Abstract [en]

    Oxidative stress has been suggested as a mediator in life-history trade-off. By spending more resources on for example reproduction an organism might sacrifice its antioxidant defence. So far, most conclusions on trade-offs between life-history traits and oxidative stress have been drawn from laboratory studies using a few model species and there is a need for studies conducted in natural settings. We investigated associations between markers for antioxidant status (antioxidant enzyme activities and antioxidant levels), body condition, age and reproduction in three species of wild-living passerines. The impact from an anthropogenic stressor (metal pollution) was also assessed. The three bird species showed interspecific variation in their SOD and CAT activities, indicating different pathways to eliminate radicals. The age of females affected both antioxidant status and the breeding performance, indicating the importance of age as a factor in life-history studies. Old birds had lower levels of antioxidants/antioxidant enzyme activities and they produced larger broods/more successful broods, though the latter might be confounded by surviving females having increased fitness. Metal exposure had a negative impact on breeding, and improved breeding outcome was also associated with increased antioxidant defence, but metal exposure was not directly related to the oxidative status of birds, emphasizing that additional stressors might independently affect the same traits. Our results highlight that caution has to be taken when generalizing and extrapolating results to even closely related species. The results support the idea that there is a cost of reproduction, in terms of increased resources spent on antioxidant defence, though this should be confirmed with experimental studies.

  • 39.
    Bergsten, Anna
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Evolution, Ecological Botany.
    Population Differentiation in Solidago virgaurea along Altitudinal Gradients2009Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Altitudinal gradients offer attractive opportunities for studies of population differentiation in response to environmental heterogeneity. In this thesis, I examined population differentiation along altitudinal gradients by combining common-garden experiments with field studies and experiments in alpine, subalpine and boreal populations of the perennial herb Solidago virgaurea. More specifically, I determined whether leaf physiology in terms of nitrogen concentration and resorption, flowering phenology, flower production and reproductive effort vary along altitudinal gradients.

    Nitrogen concentration in green leaves were higher in alpine than in subalpine and boreal populations. These differences persisted when plants were grown from seeds in a common-garden experiment at two sites, suggesting that the differences have a genetic component. There was mixed support for a trade-off between maximized carbon gain through the maintenance of high nitrogen concentration, and minimized nitrogen loss through high resorption.

    In their natural habitats alpine populations began flowering later than subalpine populations, but this difference was reversed when plants were grown in a common environment. This suggests that genetic differences among populations counteract environmental effects and reduce phenotypic variation in flowering time among populations. Flowering time thus shows countergradient genetic variation in S. virgaurea.

    In a common-garden experiment, boreal populations produced more flowers and had a higher reproductive effort than subalpine and alpine populations indicating habitat-specific genetic differences in reproductive allocation. In a field study, which included three populations, seed set was close to zero in the alpine population, intermediate in the subalpine population, and high in the boreal population. Experimental flower removal showed that seed production was associated with a considerable cost in terms of reduced flowering propensity the following year, but did not support the hypothesis that a large floral display is important for pollination success.

  • 40. Bergström, Anna
    et al.
    Ljungros, Kristina
    Forsberg Nilsson, Karin
    Ericson, Emilia
    Lindenfors, Patrik
    Stockholm University, Faculty of Science, Department of Zoology, Animal Ecology. Stockholm University, Faculty of Humanities, Centre for the Study of Cultural Evolution.
    Larhammar, Dan
    Nu hotas kvinnors rätt till sina kroppar2014In: AftonbladetArticle in journal (Other (popular science, discussion, etc.))
  • 41.
    Bergström, Ulrika
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Faculty of Science and Technology, Biology, Department of Physiology and Developmental Biology. Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Faculty of Science and Technology, Biology, Department of Physiology and Developmental Biology. Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Faculty of Science and Technology, Biology, Department of Physiology and Developmental Biology, Environmental Toxicology. ekotoxikologi.
    Olsson, Jan
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Faculty of Science and Technology, Biology, Department of Physiology and Developmental Biology. Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Faculty of Science and Technology, Biology, Department of Physiology and Developmental Biology. Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Faculty of Science and Technology, Biology, Department of Physiology and Developmental Biology, Environmental Toxicology. ekotoxikologi.
    Hvidsten, Torgeir R
    Komorowski, Jan
    Brandt, Ingvar
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Faculty of Science and Technology, Biology, Department of Physiology and Developmental Biology. Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Faculty of Science and Technology, Biology, Department of Physiology and Developmental Biology. Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Faculty of Science and Technology, Biology, Department of Physiology and Developmental Biology, Environmental Toxicology. ekotoxikologi.
    Neurotoxicity of the Olfactory toxicant 2,6-Dichlorophenyl Methylsulphone in Olfactory bulb:Impaired expression of genes relating to neurodegenerative disease2007In: DIOXIN2007, 2007, 1841-1844 p.Conference paper (Refereed)
  • 42. Berntsson, Jonna
    et al.
    Lundgren, Sebastian
    Nodin, Björn
    Uhlén, Mathias
    KTH, School of Biotechnology (BIO), Proteomics and Nanobiotechnology. KTH, Centres, Science for Life Laboratory, SciLifeLab.
    Gaber, Alexander
    Jirström, Karin
    Expression and prognostic significance of the polymeric immunoglobulin receptor in epithelial ovarian cancer2014In: Journal of Ovarian Research, ISSN 1757-2215, Vol. 7, no 1, 26- p.Article in journal (Refereed)
    Abstract [en]

    Background: High expression of the polymeric immunoglobulin receptor (PIGR) has previously been associated with a favourable prognosis in a few cancer forms, but its expression and relationship with clinical outcome in epithelial ovarian cancer (EOC) has not yet been reported. The aim of this study was therefore to examine the clinicopathological correlates and prognostic significance of PIGR expression in EOC. Methods: After an initial screening in the Human Protein Atlas portal, a validated antibody was selected for extended analysis of immunohistochemical PIGR expression in tissue microarrays with tumours from 154 incident cases of EOC from two pooled prospective population-based cohorts. Subsets of corresponding benign-appearing fallopian tubes (n = 38) and omental metastases (n = 33) were also analysed. Kaplan-Meier analysis and Cox regression analysis were applied to examine the impact of PIGR expression on overall survival (OS) and ovarian cancer-specific survival (OCSS). Results: PIGR expression was significantly higher in fallopian tubes compared to primary tumours and metastases (p < 0.001) and lower in carcinoma of the serous subtype compared to other carcinomas (p < 0.001). PIGR expression was significantly associated with lower grade (p = 0.001), mucinous histological subtype (p = 0.002), positive progesterone receptor expression (p = 0.009) and negative or low Ki-67 expression (p = 0.003). Kaplan-Meier analysis revealed a significantly improved OS (p = 0.013) and OCSS (p = 0.009) for patients with tumours displaying high expression of PIGR. These associations were confirmed in unadjusted Cox regression analysis (HR = 0.48; 95% CI 0.26-0.87; p = 0.015 for OS and HR = 0.43, 95% CI 0.22-0.82; p = 0.011 for OCSS) but did not remain significant after adjustment for age, grade and clinical stage. Conclusions: This study provides a first demonstration of PIGR expression in human fallopian tubes, primary EOC tumours and metastases. High tumour-specific expression of PIGR was found to be associated with a favourable prognosis in unadjusted, but not in adjusted, analysis. These findings are novel and merit further investigation.

  • 43.
    Bisang, Irene
    et al.
    Swedish Museum of Natural History, Department of Botany.
    Hedenäs, Lars
    Swedish Museum of Natural History, Department of Botany.
    Drepanocladus turgescens (T. Jensen) Broth. doch im Engadin2017In: Meylania, ISSN 1018-8142, Vol. 59, 9-13 p.Article in journal (Other (popular science, discussion, etc.))
  • 44. Björn, Lars Olof
    et al.
    Bengtson, Sven-Axel
    Shaoshan, Li
    Hecker, Christoph
    Ullah, Saleem
    Roos, Arne
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Physics.
    Nilsson, Annica M.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Physics.
    Thermal emissivity of avian eggshells2016In: Journal of Thermal Biology, ISSN 0306-4565, E-ISSN 1879-0992, Vol. 57, 1-5 p.Article in journal (Refereed)
    Abstract [en]

    The hypothesis has been tested that evolution has resulted in lower thermal emissivity of eggs of birds breeding openly in cold climates than of eggs of birds that nest under protective covering or in warmer climates. Directional thermal emissivity has been estimated from directional-hemispherical reflectance spectra. Due to several methodological difficulties the absolute emissivity is not accurately determined, but differences between species are obvious. Most notably, small waders of the genus Calidris, breeding in cold climates on the tundra, and in most cases with uniparental nest attendance, have low directional emissivity of their eggshells, about 0.92 when integration is carried out for wavelengths up to 16 mu m. Species belonging to Galloanserinae have the highest directional emissivity, about 0.96, of their eggs. No differences due to climate or breeding conditions were found within this group. Eggs of most other birds tested possess intermediate emissivity, but the values for Pica pica and Corvus corone cornix are as low as for Calidris. Large species-dependent differences in spectral reflectance were found at specific wavelengths. For instance, at 4.259 mu m the directional-hemispherical reflectance for galliforms range from 0.05 to 0.09, while for Fratercula arctica and Fulmarus glacialis it is about 0.3. The reflection peaks at 6.5 and 11.3 mu m due to calcite are differentially attenuated in different species. In conclusion, the hypothesis that evolution has resulted in lower thermal emissivity of bird eggs being exposed in cold climates is not supported by our results. The emissivity is not clearly related to nesting habits or climate, and it is unlikely that the small differences observed are ecologically important. The spectral differences between eggs that nevertheless exist should be taken into account when using infrared thermometers for estimating the surface temperature of avian eggs.

  • 45.
    Boalt, Elin
    Stockholm University, Faculty of Science, Department of Botany.
    Ecology and evolution of tolerance in two cruciferous species2008Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Tolerance to herbivory is the ability of plants to maintain fitness in spite of damage. The goal of this thesis is to investigate the genetic variation and expression of tolerance within species, determine whether and in what conditions tolerance has negative side-effects, and how tolerance is affected by different ecological factors. Tolerance is investigated with special focus on the effects of different damage types, competitive regimes, history of herbivory, and polyploidization in plants. Studies are conducted as a literature review and three experiments on two cruciferous species Raphanus raphanistrum and Cardamine pratensis.

    In the tolerance experiments, plants are subjected to artificial damage solely, or in a combination with natural damage. A literature review was conducted in order to investigate the effects of damage method. We found that traits related to tolerance, such as growth and fitness were not as sensitive in regard to damage method as measures of induced chemical traits, or measures of secondary herbivory.

    Genetic variation of tolerance was demonstrated within populations of R. raphanistrum and between subspecies of C. pratensis. In R. raphanistrum, traits involved in floral display and male fitness were positively associated with plant tolerance to herbivore damage. A potential cost of tolerance was demonstrated as a negative correlation between levels of tolerance in high and low competitive regimes. I found no evidence of other proposed costs of tolerance in terms of highly tolerant plants suffering of reduced fitness in the absence of herbivores or trade-offs in terms of a negative association between tolerance to apical and leaf damage, or between tolerance and competitive ability. In C. pratensis, higher ploidy level in plants involved higher levels of tolerance measured as clonal reproduction. Furthermore, populations exposed to higher levels of herbivory had better tolerance than populations exposed to lower levels of herbivory. In this thesis, I demonstrate evidence of different components for the evolution of tolerance in plants: genotypic variation, selective factors in terms of costs and ploidization, and selective agents in terms of changing environment or herbivore pressure.

  • 46.
    Boalt, Elin
    Södertörn University, School of Life Sciences.
    Ecology and evolution of tolerance in two cruciferous species2008Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Tolerance to herbivory is the ability of plants to maintain fitness in spite of damage. The goal of this thesis is to investigate the genetic variation and expression of tolerance within species, determine whether and in what conditions tolerance has negative side-effects, and how tolerance is affected by different ecological factors. Tolerance is investigated with special focus on the effects of different damage types, competitive regimes, history of herbivory, and polyploidization in plants. Studies are conducted as a literature review and three experiments on two cruciferous species Raphanus raphanistrum and Cardamine pratensis.

    In the tolerance experiments, plants are subjected to artificial damage solely, or in a combination with natural damage. A literature review was conducted in order to investigate the effects of damage method. We found that traits related to tolerance, such as growth and fitness were not as sensitive in regard to damage method as measures of induced chemical traits, or measures of secondary herbivory.

    Genetic variation of tolerance was demonstrated within populations of R. raphanistrum and between subspecies of C. pratensis. In R. raphanistrum, traits involved in floral display and male fitness were positively associated with plant tolerance to herbivore damage. A potential cost of tolerance was demonstrated as a negative correlation between levels of tolerance in high and low competitive regimes. I found no evidence of other proposed costs of tolerance in terms of highly tolerant plants suffering of reduced fitness in the absence of herbivores or trade-offs in terms of a negative association between tolerance to apical and leaf damage, or between tolerance and competitive ability. In C. pratensis, higher ploidy level in plants involved higher levels of tolerance measured as clonal reproduction. Furthermore, populations exposed to higher levels of herbivory had better tolerance than populations exposed to lower levels of herbivory. In this thesis, I demonstrate evidence of different components for the evolution of tolerance in plants: genotypic variation, selective factors in terms of costs and ploidization, and selective agents in terms of changing environment or herbivore pressure.

  • 47.
    Bodin, Hristina
    et al.
    Kristianstad University, Research environment Man & Biosphere Health (MABH). Kristianstad University, School of Education and Environment, Avdelningen för Naturvetenskap. SLU, Alnarp.
    Asp, Håkan
    SLU, Alnarp.
    Hultberg, Malin
    SLU, Alnarp.
    Effects of biopellets composed of microalgae and fungi on cadmium present at environmentally relevant levels in water2017In: International journal of phytoremediation, ISSN 1522-6514, E-ISSN 1549-7879, Vol. 19, no 5, 500-504 p.Article in journal (Refereed)
    Abstract [en]

    Removal of cadmium (Cd) present at low levels (1 µg L−1) in water was investigated using three different microorganism treatments: the microalga Chlorella vulgaris, the fungus Aspergillus niger and for the first time biopellets composed of C. vulgaris and A. niger. After 5 days, all microorganism treatments resulted in significantly lower Cd concentrations compared with the control. Biopellets treatment resulted in significantly lower pH values than other microorganism treatments, indicating that the biopellets should be investigated further for their water treatment capacity, since pH is a factor affecting the fate of numerous pollutants in water. Use of biopellets as a method to simplify harvesting of microalgae from water is also suggested.

  • 48.
    Bohlin, Emma
    University of Gävle, Faculty of Engineering and Sustainable Development, Department of Electronics, Mathematics and Natural Sciences.
    Trädgårdens betydelse för medlemmar i bostadsrättsföreningar: –ur ett hälsomässigt, estetiskt och skötselmässigt perspektiv2012Independent thesis Basic level (university diploma), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Syftet med studien handlar om att försöka förstå vilken betydelse trädgårdsmiljön har för människor som bor i bostadsrättslägenheter - ur ett hälsomässigt, estetiskt och skötselmässigt perspektiv. Framför allt handlar studien om att ta reda på hur medlemmarna använder sin trädgård och om den har någon hälsomässig betydelse. Studien ska undersöka hur de ser på utformningen av trädgårdsmiljön i sitt bostadsområde, samt hur de skulle föredra att ha den. Den ska också undersöka vilken syn medlemmarna har på skötselfrågan och hur föreningen valt att lösa skötseln av trädgården. Studien bygger på fem kvalitativa intervjuer med representanter från bostadsrättsföreningar som fått besvara frågor om medlemmarnas syn på sina trädgårdsmiljöer.

  • 49.
    Bohlin, Matilda
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Biology Education Centre.
    DEHP - från mjukgörare till hormonstörande2014Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 50. Bondesson, Maria
    et al.
    Jönsson, Jill
    Pongratz, Ingemar
    Olea, Nicholas
    Cravedi, Jean-Pierre
    Zalko, Daniel
    Håkansson, Helen
    Halldin, Krister
    Institutet för miljömedicin, Karolinska Institutet.
    Di Lorenzo, Diego
    Behl, Christian
    Manthey, Dieter
    Balaguer, Patrick
    Demeneix, Barbara
    Fini, Jean Baptiste
    Laudet, Vincent
    Gustafsson, Jan-Ake
    A CASCADE of effects of bisphenol A.2009In: Reproductive Toxicology, ISSN 0890-6238, E-ISSN 1873-1708, Vol. 28, no 4, 563-7 p.Article in journal (Refereed)
1234567 1 - 50 of 352
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