Change search
Refine search result
17181920 951 - 986 of 986
CiteExportLink to result list
Permanent link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Rows per page
  • 5
  • 10
  • 20
  • 50
  • 100
  • 250
Sort
  • Standard (Relevance)
  • Author A-Ö
  • Author Ö-A
  • Title A-Ö
  • Title Ö-A
  • Publication type A-Ö
  • Publication type Ö-A
  • Issued (Oldest first)
  • Issued (Newest first)
  • Created (Oldest first)
  • Created (Newest first)
  • Last updated (Oldest first)
  • Last updated (Newest first)
  • Disputation date (earliest first)
  • Disputation date (latest first)
  • Standard (Relevance)
  • Author A-Ö
  • Author Ö-A
  • Title A-Ö
  • Title Ö-A
  • Publication type A-Ö
  • Publication type Ö-A
  • Issued (Oldest first)
  • Issued (Newest first)
  • Created (Oldest first)
  • Created (Newest first)
  • Last updated (Oldest first)
  • Last updated (Newest first)
  • Disputation date (earliest first)
  • Disputation date (latest first)
Select
The maximal number of hits you can export is 250. When you want to export more records please use the Create feeds function.
  • 951.
    Wikström, Gerhard
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    Lindmark, K.
    Umea Univ, Dept Publ Hlth & Clin Med, Ctr Heart, Umea, Sweden..
    Olofsson, M.
    Umea Univ, Dept Publ Hlth & Clin Med, Res Unit, Med, Umea, Sweden..
    Stålhammar, Jan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Bergman, G. J.
    QuintilesIMS, Solna, Sweden..
    Tornblom, M.
    QuintilesIMS, Solna, Sweden..
    Wintzell, V.
    QuintilesIMS, Solna, Sweden..
    Wirta, S. Bruce
    Novartis Pharma AG, Basel, Switzerland..
    Balas, B.
    Novartis Pharma AG, Basel, Switzerland..
    Boman, K.
    Umea Univ, Dept Publ Hlth & Clin Med, Res Unit, Med, Umea, Sweden..
    Drug treatment patterns in patients newly diagnosed with heart failure: a retrospective population-based cohort study in Sweden2017In: European Journal of Heart Failure, ISSN 1388-9842, E-ISSN 1879-0844, Vol. 19, no Suppl. 1, p. 55-55Article in journal (Other academic)
  • 952. Willer, Cristen J.
    et al.
    Schmidt, Ellen M.
    Sengupta, Sebanti
    Peloso, Gina M.
    Gustafsson, Stefan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Kanoni, Stavroula
    Ganna, Andrea
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Chen, Jin
    Buchkovich, Martin L.
    Mora, Samia
    Beckmann, Jacques S.
    Bragg-Gresham, Jennifer L.
    Chang, Hsing-Yi
    Demirkan, Ayse
    Den Hertog, Heleen M.
    Do, Ron
    Donnelly, Louise A.
    Ehret, Georg B.
    Esko, Tonu
    Feitosa, Mary F.
    Ferreira, Teresa
    Fischer, Krista
    Fontanillas, Pierre
    Fraser, Ross M.
    Freitag, Daniel F.
    Gurdasani, Deepti
    Heikkila, Kauko
    Hyppoenen, Elina
    Isaacs, Aaron
    Jackson, Anne U.
    Johansson, Åsa
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Genomics. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
    Johnson, Toby
    Kaakinen, Marika
    Kettunen, Johannes
    Kleber, Marcus E.
    Li, Xiaohui
    Luan, Jian'an
    Lyytikainen, Leo-Pekka
    Magnusson, Patrik K. E.
    Mangino, Massimo
    Mihailov, Evelin
    Montasser, May E.
    Mueller-Nurasyid, Martina
    Nolte, Ilja M.
    O'Connell, Jeffrey R.
    Palmer, Cameron D.
    Perola, Markus
    Petersen, Ann-Kristin
    Sanna, Serena
    Saxena, Richa
    Service, Susan K.
    Shah, Sonia
    Shungin, Dmitry
    Sidore, Carlo
    Song, Ci
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Strawbridge, Rona J.
    Surakka, Ida
    Tanaka, Toshiko
    Teslovich, Tanya M.
    Thorleifsson, Gudmar
    Van den Herik, Evita G.
    Voight, Benjamin F.
    Volcik, Kelly A.
    Waite, Lindsay L.
    Wong, Andrew
    Wu, Ying
    Zhang, Weihua
    Absher, Devin
    Asiki, Gershim
    Barroso, Ines
    Been, Latonya F.
    Bolton, Jennifer L.
    Bonnycastle, Lori L.
    Brambilla, Paolo
    Burnett, Mary S.
    Cesana, Giancarlo
    Dimitriou, Maria
    Doney, Alex S. F.
    Doering, Angela
    Elliott, Paul
    Epstein, Stephen E.
    Eyjolfsson, Gudmundur Ingi
    Gigante, Bruna
    Goodarzi, Mark O.
    Grallert, Harald
    Gravito, Martha L.
    Groves, Christopher J.
    Hallmans, Goran
    Hartikainen, Anna-Liisa
    Hayward, Caroline
    Hernandez, Dena
    Hicks, Andrew A.
    Holm, Hilma
    Hung, Yi-Jen
    Illig, Thomas
    Jones, Michelle R.
    Kaleebu, Pontiano
    Kastelein, John J. P.
    Khaw, Kay-Tee
    Kim, Eric
    Klopp, Norman
    Komulainen, Pirjo
    Kumari, Meena
    Langenberg, Claudia
    Lehtimaki, Terho
    Lin, Shih-Yi
    Lindstrom, Jaana
    Loos, Ruth J. F.
    Mach, Francois
    McArdle, Wendy L.
    Meisinger, Christa
    Mitchell, Braxton D.
    Mueller, Gabrielle
    Nagaraja, Ramaiah
    Narisu, Narisu
    Nieminen, Tuomo V. M.
    Nsubuga, Rebecca N.
    Olafsson, Isleifur
    Ong, Ken K.
    Palotie, Aarno
    Papamarkou, Theodore
    Pomilla, Cristina
    Pouta, Anneli
    Rader, Daniel J.
    Reilly, Muredach P.
    Ridker, Paul M.
    Rivadeneira, Fernando
    Rudan, Igor
    Ruokonen, Aimo
    Samani, Nilesh
    Scharnagl, Hubert
    Seeley, Janet
    Silander, Kaisa
    Stancakova, Alena
    Stirrups, Kathleen
    Swift, Amy J.
    Tiret, Laurence
    Uitterlinden, Andre G.
    van Pelt, L. Joost
    Vedantam, Sailaja
    Wainwright, Nicholas
    Wijmenga, Cisca
    Wild, Sarah H.
    Willemsen, Gonneke
    Wilsgaard, Tom
    Wilson, James F.
    Young, Elizabeth H.
    Zhao, Jing Hua
    Adair, Linda S.
    Arveiler, Dominique
    Assimes, Themistocles L.
    Bandinelli, Stefania
    Bennett, Franklyn
    Bochud, Murielle
    Boehm, Bernhard O.
    Boomsma, Dorret I.
    Borecki, Ingrid B.
    Bornstein, Stefan R.
    Bovet, Pascal
    Burnier, Michel
    Campbell, Harry
    Chakravarti, Aravinda
    Chambers, John C.
    Chen, Yii-Der Ida
    Collins, Francis S.
    Cooper, Richard S.
    Danesh, John
    Dedoussis, George
    de Faire, Ulf
    Feranil, Alan B.
    Ferrieres, Jean
    Ferrucci, Luigi
    Freimer, Nelson B.
    Gieger, Christian
    Groop, Leif C.
    Gudnason, Vilmundur
    Gyllensten, Ulf
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Genomics.
    Hamsten, Anders
    Harris, Tamara B.
    Hingorani, Aroon
    Hirschhorn, Joel N.
    Hofman, Albert
    Hovingh, G. Kees
    Hsiung, Chao Agnes
    Humphries, Steve E.
    Hunt, Steven C.
    Hveem, Kristian
    Iribarren, Carlos
    Jarvelin, Marjo-Riitta
    Jula, Antti
    Kahonen, Mika
    Kaprio, Jaakko
    Kesaniemi, Antero
    Kivimaki, Mika
    Kooner, Jaspal S.
    Koudstaal, Peter J.
    Krauss, Ronald M.
    Kuh, Diana
    Kuusisto, Johanna
    Kyvik, Kirsten O.
    Laakso, Markku
    Lakka, Timo A.
    Lind, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology.
    Lindgren, Cecilia M.
    Martin, Nicholas G.
    Maerz, Winfried
    McCarthy, Mark I.
    McKenzie, Colin A.
    Meneton, Pierre
    Metspalu, Andres
    Moilanen, Leena
    Morris, Andrew D.
    Munroe, Patricia B.
    Njolstad, Inger
    Pedersen, Nancy L.
    Power, Chris
    Pramstaller, Peter P.
    Price, Jackie F.
    Psaty, Bruce M.
    Quertermous, Thomas
    Rauramaa, Rainer
    Saleheen, Danish
    Salomaa, Veikko
    Sanghera, Dharambir K.
    Saramies, Jouko
    Schwarz, Peter E. H.
    Sheu, Wayne H-H
    Shuldiner, Alan R.
    Siegbahn, Agneta
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Coagulation and inflammation science.
    Spector, Tim D.
    Stefansson, Kari
    Strachan, David P.
    Tayo, Bamidele O.
    Tremoli, Elena
    Tuomilehto, Jaakko
    Uusitupa, Matti
    van Duijn, Cornelia M.
    Vollenweider, Peter
    Wallentin, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    Wareham, Nicholas J.
    Whitfield, John B.
    Wolffenbuttel, Bruce H. R.
    Ordovas, Jose M.
    Boerwinkle, Eric
    Palmer, Colin N. A.
    Thorsteinsdottir, Unnur
    Chasman, Daniel I.
    Rotter, Jerome I.
    Franks, Paul W.
    Ripatti, Samuli
    Cupples, L. Adrienne
    Sandhu, Manjinder S.
    Rich, Stephen S.
    Boehnke, Michael
    Deloukas, Panos
    Kathiresan, Sekar
    Mohlke, Karen L.
    Ingelsson, Erik
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Abecasis, Goncalo R.
    Discovery and refinement of loci associated with lipid levels2013In: Nature Genetics, ISSN 1061-4036, E-ISSN 1546-1718, Vol. 45, no 11, p. 1274-1283Article in journal (Refereed)
    Abstract [en]

    Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with lipid levels at P < 5 x 10(-8), including 62 loci not previously associated with lipid levels in humans. Using dense genotyping in individuals of European, East Asian, South Asian and African ancestry, we narrow association signals in 12 loci. We find that loci associated with blood lipid levels are often associated with cardiovascular and metabolic traits, including coronary artery disease, type 2 diabetes, blood pressure, waist-hip ratio and body mass index. Our results demonstrate the value of using genetic data from individuals of diverse ancestry and provide insights into the biological mechanisms regulating blood lipids to guide future genetic, biological and therapeutic research.

  • 953.
    Williams, Rachel
    et al.
    GlaxoSmithKline, Worldwide Epidemiol, Collegeville, PA USA..
    Shearn, Shawn Patrick
    GlaxoSmithKline, Ophthalmol Res & Dev, Philadelphia, PA USA..
    Dowd, Michael
    Bogier Clin & IT Solut Inc, Raleigh, NC USA..
    Cicconetti, Greg
    GlaxoSmithKline, Quantitat Sci, Philadelphia, PA USA..
    Wallentin, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    White, Harvey
    Auckland City Hosp, Green Lane Cardiovasc Serv, Auckland, New Zealand.;Univ Auckland, Auckland 1, New Zealand..
    Janmohamed, Salim
    Wurzelmann, John I.
    GlaxoSmithKline, Ophthalmol Res & Dev, Philadelphia, PA USA..
    McLaughlin, Megan M.
    GlaxoSmithKline, Ophthalmol Res & Dev, Philadelphia, PA USA..
    Post-hoc analyses of darapladib, an oral Lp-PLA(2) inhibitor, in phase III cardiovascular outcomes trials may inform investigation in diabetic macular edema2015In: Investigative Ophthalmology and Visual Science, ISSN 0146-0404, E-ISSN 1552-5783, Vol. 56, no 7Article in journal (Other academic)
  • 954.
    Witt, Nils
    et al.
    Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, and Unit of Cardiology, Södersjukhuset, Stockholm, Sweden.
    Rück, Andreas
    Department of Medicine, Karolinska Institutet, and Department of Cardiology, Karolinska University Hospital, Stockholm.
    James, Stefan K
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Physiology.
    Koul, Sasha
    Department of Cardiology, Skåne University Hospital, Lund University, Lund, Sweden .
    Lagerqvist, Bo
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    Sweden: coronary and structural heart interventions from 2010 to 20152017In: EuroIntervention, ISSN 1774-024X, E-ISSN 1969-6213, Vol. 13, no Z, p. Z70-Z74, article id EIJ-D-16-00830Article in journal (Refereed)
    Abstract [en]

    Sparsely populated and with wide non-urbanised areas, Sweden faces specific challenges in providing publicly financed, high-quality and equal healthcare to all parts of the country. As a result, a decentralised organisation for acute coronary care has been developed with coronary care units and catheterisation laboratories in several small- and medium-sized city areas. In contrast, highly specialised non-emergent interventional procedures are centralised to a few high-volume centres, mainly located at university hospitals in large city areas. Nationwide quality registries with nearly complete coverage facilitate healthcare quality improvement and form a basis for clinical research. In this report, we present an overview of demographics, healthcare organisation, quality registries and procedural data for coronary and structural heart interventions in Sweden over the past six years.

  • 955.
    Wollert, Kai C.
    et al.
    Hannover Med Sch, Dept Cardiol & Angiol, Div Mol & Translat Cardiol, Hannover, Germany..
    Kempf, Tibor
    Hannover Med Sch, Dept Cardiol & Angiol, Div Mol & Translat Cardiol, Hannover, Germany..
    Wallentin, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
    Growth Differentiation Factor 15 as a Biomarker in Cardiovascular Disease2017In: Clinical Chemistry, ISSN 0009-9147, E-ISSN 1530-8561, Vol. 63, no 1, p. 140-151Article, review/survey (Refereed)
    Abstract [en]

    BACKGROUND: Growth differentiation factor 15 (GDF-15) is expressed and secreted in response to inflammation, oxidative stress, hypoxia, telomere erosion, and oncogene activation. Cardiovascular (CV) disease is a major. driver of GDF-15 production. GDF-15 has favorable preanalytic characteristics and can be measured in serum and plasma by immunoassay. CONTENT: In community-dwelling individuals higher concentrations of GDF-15 are associated with increased risks of developing CV disease, chronic kidney disease, and cancer, independent of traditional CV risk factors, renal function, and other biomarkers (C-reactive protein, B-type natriuretic peptide, cardiac troponin). Low concentrations of GDF-15 are closely associated with longevity. GDF-15 is as an independent marker of all-cause mortality and CV events in patients with coronary artery disease, and may help select patients with non-ST-elevation acute coronary syndrome for early revascularization and more intensive medical therapies. GDF-15 is, independently associated with mortality and nonfatal events in atrial fibrillation and heart failure (HF) with preserved or reduced ejection fraction. GDF-15 reflects chronic disease burden and acute perturbations in HF and responds to improvements in hemodynamic status. GDF-15 is independently associated with major bleeding in patients receiving antithrombotic therapies and has been included in a new bleeding risk score, which may become useful for decision support. SUMMARY: GDF-15 captures distinct aspects of CV disease development, progression, and prognosis, which are not represented by clinical risk predictors and other biomarkers. The usefulness of GDF-15 to guide management decisions and discover new treatment targets should be further explored.

  • 956. Wood, Andrew R
    et al.
    Esko, Tonu
    Yang, Jian
    Vedantam, Sailaja
    Pers, Tune H
    Gustafsson, Stefan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Chu, Audrey Y
    Estrada, Karol
    Luan, Jian'an
    Kutalik, Zoltán
    Amin, Najaf
    Buchkovich, Martin L
    Croteau-Chonka, Damien C
    Day, Felix R
    Duan, Yanan
    Fall, Tove
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Fehrmann, Rudolf
    Ferreira, Teresa
    Jackson, Anne U
    Karjalainen, Juha
    Lo, Ken Sin
    Locke, Adam E
    Mägi, Reedik
    Mihailov, Evelin
    Porcu, Eleonora
    Randall, Joshua C
    Scherag, André
    Vinkhuyzen, Anna A E
    Westra, Harm-Jan
    Winkler, Thomas W
    Workalemahu, Tsegaselassie
    Zhao, Jing Hua
    Absher, Devin
    Albrecht, Eva
    Anderson, Denise
    Baron, Jeffrey
    Beekman, Marian
    Demirkan, Ayse
    Ehret, Georg B
    Feenstra, Bjarke
    Feitosa, Mary F
    Fischer, Krista
    Fraser, Ross M
    Goel, Anuj
    Gong, Jian
    Justice, Anne E
    Kanoni, Stavroula
    Kleber, Marcus E
    Kristiansson, Kati
    Lim, Unhee
    Lotay, Vaneet
    Lui, Julian C
    Mangino, Massimo
    Leach, Irene Mateo
    Medina-Gomez, Carolina
    Nalls, Michael A
    Nyholt, Dale R
    Palmer, Cameron D
    Pasko, Dorota
    Pechlivanis, Sonali
    Prokopenko, Inga
    Ried, Janina S
    Ripke, Stephan
    Shungin, Dmitry
    Stancáková, Alena
    Strawbridge, Rona J
    Sung, Yun Ju
    Tanaka, Toshiko
    Teumer, Alexander
    Trompet, Stella
    van der Laan, Sander W
    van Setten, Jessica
    Van Vliet-Ostaptchouk, Jana V
    Wang, Zhaoming
    Yengo, Loïc
    Zhang, Weihua
    Afzal, Uzma
    Arnlöv, Johan
    Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology.
    Arscott, Gillian M
    Bandinelli, Stefania
    Barrett, Amy
    Bellis, Claire
    Bennett, Amanda J
    Berne, Christian
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical diabetology and metabolism.
    Blüher, Matthias
    Bolton, Jennifer L
    Böttcher, Yvonne
    Boyd, Heather A
    Bruinenberg, Marcel
    Buckley, Brendan M
    Buyske, Steven
    Caspersen, Ida H
    Chines, Peter S
    Clarke, Robert
    Claudi-Boehm, Simone
    Cooper, Matthew
    Daw, E Warwick
    De Jong, Pim A
    Deelen, Joris
    Delgado, Graciela
    Denny, Josh C
    Dhonukshe-Rutten, Rosalie
    Dimitriou, Maria
    Doney, Alex S F
    Dörr, Marcus
    Eklund, Niina
    Eury, Elodie
    Folkersen, Lasse
    Garcia, Melissa E
    Geller, Frank
    Giedraitis, Vilmantas
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
    Go, Alan S
    Grallert, Harald
    Grammer, Tanja B
    Gräßler, Jürgen
    Grönberg, Henrik
    de Groot, Lisette C P G M
    Groves, Christopher J
    Haessler, Jeffrey
    Hall, Per
    Haller, Toomas
    Hallmans, Goran
    Hannemann, Anke
    Hartman, Catharina A
    Hassinen, Maija
    Hayward, Caroline
    Heard-Costa, Nancy L
    Helmer, Quinta
    Hemani, Gibran
    Henders, Anjali K
    Hillege, Hans L
    Hlatky, Mark A
    Hoffmann, Wolfgang
    Hoffmann, Per
    Holmen, Oddgeir
    Houwing-Duistermaat, Jeanine J
    Illig, Thomas
    Isaacs, Aaron
    James, Alan L
    Jeff, Janina
    Johansen, Berit
    Johansson, Åsa
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Genomics. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Jolley, Jennifer
    Juliusdottir, Thorhildur
    Junttila, Juhani
    Kho, Abel N
    Kinnunen, Leena
    Klopp, Norman
    Kocher, Thomas
    Kratzer, Wolfgang
    Lichtner, Peter
    Lind, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology.
    Lindström, Jaana
    Lobbens, Stéphane
    Lorentzon, Mattias
    Lu, Yingchang
    Lyssenko, Valeriya
    Magnusson, Patrik K E
    Mahajan, Anubha
    Maillard, Marc
    McArdle, Wendy L
    McKenzie, Colin A
    McLachlan, Stela
    McLaren, Paul J
    Menni, Cristina
    Merger, Sigrun
    Milani, Lili
    Moayyeri, Alireza
    Monda, Keri L
    Morken, Mario A
    Müller, Gabriele
    Müller-Nurasyid, Martina
    Musk, Arthur W
    Narisu, Narisu
    Nauck, Matthias
    Nolte, Ilja M
    Nöthen, Markus M
    Oozageer, Laticia
    Pilz, Stefan
    Rayner, Nigel W
    Renstrom, Frida
    Robertson, Neil R
    Rose, Lynda M
    Roussel, Ronan
    Sanna, Serena
    Scharnagl, Hubert
    Scholtens, Salome
    Schumacher, Fredrick R
    Schunkert, Heribert
    Scott, Robert A
    Sehmi, Joban
    Seufferlein, Thomas
    Shi, Jianxin
    Silventoinen, Karri
    Smit, Johannes H
    Smith, Albert Vernon
    Smolonska, Joanna
    Stanton, Alice V
    Stirrups, Kathleen
    Stott, David J
    Stringham, Heather M
    Sundström, Johan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    Swertz, Morris A
    Syvänen, Ann-Christine
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Tayo, Bamidele O
    Thorleifsson, Gudmar
    Tyrer, Jonathan P
    van Dijk, Suzanne
    van Schoor, Natasja M
    van der Velde, Nathalie
    van Heemst, Diana
    van Oort, Floor V A
    Vermeulen, Sita H
    Verweij, Niek
    Vonk, Judith M
    Waite, Lindsay L
    Waldenberger, Melanie
    Wennauer, Roman
    Wilkens, Lynne R
    Willenborg, Christina
    Wilsgaard, Tom
    Wojczynski, Mary K
    Wong, Andrew
    Wright, Alan F
    Zhang, Qunyuan
    Arveiler, Dominique
    Bakker, Stephan J L
    Beilby, John
    Bergman, Richard N
    Bergmann, Sven
    Biffar, Reiner
    Blangero, John
    Boomsma, Dorret I
    Bornstein, Stefan R
    Bovet, Pascal
    Brambilla, Paolo
    Brown, Morris J
    Campbell, Harry
    Caulfield, Mark J
    Chakravarti, Aravinda
    Collins, Rory
    Collins, Francis S
    Crawford, Dana C
    Cupples, L Adrienne
    Danesh, John
    de Faire, Ulf
    den Ruijter, Hester M
    Erbel, Raimund
    Erdmann, Jeanette
    Eriksson, Johan G
    Farrall, Martin
    Ferrannini, Ele
    Ferrières, Jean
    Ford, Ian
    Forouhi, Nita G
    Forrester, Terrence
    Gansevoort, Ron T
    Gejman, Pablo V
    Gieger, Christian
    Golay, Alain
    Gottesman, Omri
    Gudnason, Vilmundur
    Gyllensten, Ulf
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Genomics. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Haas, David W
    Hall, Alistair S
    Harris, Tamara B
    Hattersley, Andrew T
    Heath, Andrew C
    Hengstenberg, Christian
    Hicks, Andrew A
    Hindorff, Lucia A
    Hingorani, Aroon D
    Hofman, Albert
    Hovingh, G Kees
    Humphries, Steve E
    Hunt, Steven C
    Hypponen, Elina
    Jacobs, Kevin B
    Jarvelin, Marjo-Riitta
    Jousilahti, Pekka
    Jula, Antti M
    Kaprio, Jaakko
    Kastelein, John J P
    Kayser, Manfred
    Kee, Frank
    Keinanen-Kiukaanniemi, Sirkka M
    Kiemeney, Lambertus A
    Kooner, Jaspal S
    Kooperberg, Charles
    Koskinen, Seppo
    Kovacs, Peter
    Kraja, Aldi T
    Kumari, Meena
    Kuusisto, Johanna
    Lakka, Timo A
    Langenberg, Claudia
    Le Marchand, Loic
    Lehtimäki, Terho
    Lupoli, Sara
    Madden, Pamela A F
    Männistö, Satu
    Manunta, Paolo
    Marette, André
    Matise, Tara C
    McKnight, Barbara
    Meitinger, Thomas
    Moll, Frans L
    Montgomery, Grant W
    Morris, Andrew D
    Morris, Andrew P
    Murray, Jeffrey C
    Nelis, Mari
    Ohlsson, Claes
    Oldehinkel, Albertine J
    Ong, Ken K
    Ouwehand, Willem H
    Pasterkamp, Gerard
    Peters, Annette
    Pramstaller, Peter P
    Price, Jackie F
    Qi, Lu
    Raitakari, Olli T
    Rankinen, Tuomo
    Rao, D C
    Rice, Treva K
    Ritchie, Marylyn
    Rudan, Igor
    Salomaa, Veikko
    Samani, Nilesh J
    Saramies, Jouko
    Sarzynski, Mark A
    Schwarz, Peter E H
    Sebert, Sylvain
    Sever, Peter
    Shuldiner, Alan R
    Sinisalo, Juha
    Steinthorsdottir, Valgerdur
    Stolk, Ronald P
    Tardif, Jean-Claude
    Tönjes, Anke
    Tremblay, Angelo
    Tremoli, Elena
    Virtamo, Jarmo
    Vohl, Marie-Claude
    Amouyel, Philippe
    Asselbergs, Folkert W
    Assimes, Themistocles L
    Bochud, Murielle
    Boehm, Bernhard O
    Boerwinkle, Eric
    Bottinger, Erwin P
    Bouchard, Claude
    Cauchi, Stéphane
    Chambers, John C
    Chanock, Stephen J
    Cooper, Richard S
    de Bakker, Paul I W
    Dedoussis, George
    Ferrucci, Luigi
    Franks, Paul W
    Froguel, Philippe
    Groop, Leif C
    Haiman, Christopher A
    Hamsten, Anders
    Hayes, M Geoffrey
    Hui, Jennie
    Hunter, David J
    Hveem, Kristian
    Jukema, J Wouter
    Kaplan, Robert C
    Kivimaki, Mika
    Kuh, Diana
    Laakso, Markku
    Liu, Yongmei
    Martin, Nicholas G
    März, Winfried
    Melbye, Mads
    Moebus, Susanne
    Munroe, Patricia B
    Njølstad, Inger
    Oostra, Ben A
    Palmer, Colin N A
    Pedersen, Nancy L
    Perola, Markus
    Pérusse, Louis
    Peters, Ulrike
    Powell, Joseph E
    Power, Chris
    Quertermous, Thomas
    Rauramaa, Rainer
    Reinmaa, Eva
    Ridker, Paul M
    Rivadeneira, Fernando
    Rotter, Jerome I
    Saaristo, Timo E
    Saleheen, Danish
    Schlessinger, David
    Slagboom, P Eline
    Snieder, Harold
    Spector, Tim D
    Strauch, Konstantin
    Stumvoll, Michael
    Tuomilehto, Jaakko
    Uusitupa, Matti
    van der Harst, Pim
    Völzke, Henry
    Walker, Mark
    Wareham, Nicholas J
    Watkins, Hugh
    Wichmann, H-Erich
    Wilson, James F
    Zanen, Pieter
    Deloukas, Panos
    Heid, Iris M
    Lindgren, Cecilia M
    Mohlke, Karen L
    Speliotes, Elizabeth K
    Thorsteinsdottir, Unnur
    Barroso, Inês
    Fox, Caroline S
    North, Kari E
    Strachan, David P
    Beckmann, Jacques S
    Berndt, Sonja I
    Boehnke, Michael
    Borecki, Ingrid B
    McCarthy, Mark I
    Metspalu, Andres
    Stefansson, Kari
    Uitterlinden, André G
    van Duijn, Cornelia M
    Franke, Lude
    Willer, Cristen J
    Price, Alkes L
    Lettre, Guillaume
    Loos, Ruth J F
    Weedon, Michael N
    Ingelsson, Erik
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    O'Connell, Jeffrey R
    Abecasis, Goncalo R
    Chasman, Daniel I
    Goddard, Michael E
    Visscher, Peter M
    Hirschhorn, Joel N
    Frayling, Timothy M
    Defining the role of common variation in the genomic and biological architecture of adult human height2014In: Nature Genetics, ISSN 1061-4036, E-ISSN 1546-1718, Vol. 46, no 11, p. 1173-1186Article in journal (Refereed)
    Abstract [en]

    Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different numbers of variants in independent studies, we show that the most strongly associated ∼2,000, ∼3,700 and ∼9,500 SNPs explained ∼21%, ∼24% and ∼29% of phenotypic variance. Furthermore, all common variants together captured 60% of heritability. The 697 variants clustered in 423 loci were enriched for genes, pathways and tissue types known to be involved in growth and together implicated genes and pathways not highlighted in earlier efforts, such as signaling by fibroblast growth factors, WNT/β-catenin and chondroitin sulfate-related genes. We identified several genes and pathways not previously connected with human skeletal growth, including mTOR, osteoglycin and binding of hyaluronic acid. Our results indicate a genetic architecture for human height that is characterized by a very large but finite number (thousands) of causal variants.

  • 957.
    Wood, Angela M.
    et al.
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England..
    Kaptoge, Stephen
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England..
    Butterworth, Adam S.
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England..
    Willeit, Peter
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England.;Med Univ Innsbruck, Innsbruck, Austria..
    Warnakula, Samantha
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England..
    Bolton, Thomas
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England..
    Paige, Ellie
    Australian Natl Univ, Natl Ctr Epidemiol & Populat Hlth, Canberra, ACT, Australia..
    Paul, Dirk S.
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England..
    Sweeting, Michael
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England..
    Burgess, Stephen
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England.;Univ Cambridge, Cambridge Inst Publ Hlth, MRC Biostat Unit, Cambridge, England..
    Bell, Steven
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England..
    Astle, William
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England..
    Stevens, David
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England..
    Koulman, Albert
    Univ Cambridge, NIHR BRC Nutr Biomarker Lab, Cambridge, England..
    Selmer, Randi M.
    Norwegian Inst Publ Hlth, Oslo, Norway..
    Verschuren, W. M. Monique
    Natl Inst Publ Hlth & Environm, Bilthoven, Netherlands.;Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands..
    Sato, Shinichi
    Chiba Prefectural Inst Publ Hlth, Chiba, Japan..
    Njolstad, Inger
    Univ Tromso, Dept Community Med, Tromso, Norway..
    Woodward, Mark
    Univ Oxford, Nuffield Dept Populat Hlth, Med Sci Div, Oxford, England.;Univ Sydney, George Inst Global Hlth, Sydney, NSW, Australia.;Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA..
    Salomaa, Veikko
    THL Natl Inst Hlth & Welf, Helsinki, Finland..
    Nordestgaard, Borge G.
    Copenhagen Univ Hosp, Copenhagen, Denmark.;Univ Copenhagen, Dept Clin Med, Copenhagen, Denmark..
    Yeap, Bu B.
    Univ Western Australia, Sch Med, Perth, WA, Australia.;Fiona Stanley Hosp, Perth, WA, Australia.;Harry Perkins Inst Med Res, Perth, WA, Australia..
    Fletcher, Astrid
    London Sch Hyg & Trop Med, London, England..
    Melander, Olle
    Lund Univ, Dept Clin Sci, Malmo, Sweden..
    Kuller, Lewis H.
    Univ Pittsburgh, Grad Sch Publ Hlth, Pittsburgh, PA USA..
    Balkau, Beverley
    INSERM, UMRS 1018, CESP, Villejuif, France..
    Marmot, Michael
    UCL, Dept Epidemiol & Publ Hlth, London, England..
    Koenig, Wolfgang
    Tech Univ Munich, Deutsch Herzzentrum Munchen 92, DZHK German Ctr Cardiovasc Res, Partner Site Munich Heart Alliance, Munich, Germany.;Univ Ulm, Med Ctr, Ulm, Germany..
    Casiglia, Edoardo
    Univ Padua, Dept Med, Padua, Italy..
    Cooper, Cyrus
    Univ Southampton, MRC Lifecourse Epidemiol Unit, Southampton, Hants, England..
    Arndt, Volker
    German Canc Res Ctr, Heidelberg, Germany..
    Franco, Oscar H.
    Erasmus Univ, Med Ctr, Rotterdam, Netherlands..
    Wennberg, Patrik
    Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden..
    Gallacher, John
    Cardiff Univ, Dept Primary Care & Publ Hlth, Cardiff, S Glam, Wales..
    de la Camara, Agustin Gomez
    CIBERESP, Octubre Res Inst 12, Madrid, Spain..
    Volzke, Henry
    Univ Med Greifswald, Inst Community Med, Greifswald, Germany..
    Dahm, Christina C.
    Aarhus Univ, Dept Publ Hlth, Aarhus, Denmark..
    Dale, Caroline E.
    UCL, UCL Inst Hlth Informat, Farr Inst Hlth Informat Res, London, England..
    Bergmann, Manuela M.
    German Inst Human Nutr, Potsdam, Germany..
    Crespo, Carlos J.
    Portland State Univ, Sch Community Hlth, Portland, OR 97207 USA..
    van der Schouw, Yvonne T.
    Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands..
    Kaaks, Rudolf
    German Canc Res Ctr, Heidelberg, Germany..
    Simons, Leon A.
    Univ New South Wales, St Vincents Clin Sch, Sydney, NSW, Australia..
    Lagiou, Pagona
    Hellen Hlth Fdn, Athens, Greece.;Univ Athens, Athens, Greece.;Harvard TH Chan Sch Publ Hlth, Boston, MA USA..
    Schoufour, Josje D.
    Erasmus Univ, Med Ctr, Rotterdam, Netherlands..
    Boer, Jolanda M. A.
    Natl Inst Publ Hlth & Environm, Bilthoven, Netherlands..
    Key, Timothy J.
    Univ Oxford, Nuffield Dept Populat Hlth, Med Sci Div, Oxford, England..
    Rodriguez, Beatriz
    Univ Hawaii, Off Publ Hlth Studies, Honolulu, HI 96822 USA..
    Moreno-Iribas, Conchi
    Navarra Inst Hlth Res, IdiSNA, Inst Salud Publ Navarra, Pamplona, Spain.;Red Invest Serv Salud Enfermedades Cronicas REDIS, Pamplona, Spain..
    Davidson, Karina W.
    Columbia Univ Irving, Med Ctr, New York, NY USA..
    Taylor, James O.
    East Boston Neighborhood Hlth Ctr, Boston, MA USA..
    Sacerdote, Carlotta
    Citta Salute Sci Torino Hosp, Turin, Italy..
    Wallace, Robert B.
    Univ Iowa, Coll Publ Hlth, Iowa City, IA USA..
    Quiros, J. Ramon
    Consejeria Sanidad Principado Asturias, Oviedo, Asturias, Spain..
    Tumino, Rosario
    ASP, Civic M Arezzo Hosp, Ragusa, Italy..
    Blazer, Dan G., II
    Duke Univ, Duke Div Sch, Durham, NC USA..
    Linneberg, Allan
    Univ Copenhagen, Dept Clin Med, Copenhagen, Denmark..
    Daimon, Makoto
    Hirosaki Univ, Dept Endocrinol & Metab, Hirosaki, Aomori, Japan..
    Panico, Salvatore
    Univ Naples Federico II, Dept Clin & Expt Med, Naples, Italy..
    Howard, Barbara
    Tuskegee Univ, Dept Biol, Tuskegee, AL 36088 USA..
    Skeie, Guri
    UiT Arctic Univ Norway, Dept Community Med, Tromso, Norway..
    Strandberg, Timo
    Univ Helsinki, Helsinki, Finland.;Helsinki Univ Hosp, Helsinki, Finland.;Univ Oulu, Ctr Life Course Hlth Res, Oulu, Finland..
    Weiderpass, Elisabete
    UiT Arctic Univ Norway, Dept Community Med, Tromso, Norway.;Canc Registry Norway, Inst Population Based Canc Res, Oslo, Norway.;Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.;Univ Helsinki, Epidemiol Grp, Folkhalsan Res Ctr, Fac Med, Helsinki, Finland..
    Nietert, Paul J.
    Univ South Carolina, Med, Charleston, SC USA..
    Psaty, Bruce M.
    Univ Washington, Cardiovasc Hlth Res Unit, Dept Med, Seattle, WA 98195 USA.;Univ Washington, Cardiovasc Hlth Res Unit, Dept Epidemiol, Seattle, WA 98195 USA.;Univ Washington, Cardiovasc Hlth Res Unit, Dept Hlth Serv, Seattle, WA 98195 USA.;Kaiser Permanente Washington Hlth Res Inst, Seattle, WA USA..
    Kromhout, Daan
    Wageningen Univ, Dept Agrotechnol & Food Sci, Wageningen, Netherlands.;Univ Groningen, Fac Med Sci, Groningen, Netherlands.;Yale Univ, Sch Med, New Haven, CT USA..
    Salamanca-Fernandez, Elena
    Univ Granada, Hospit Univ Granada, Inst Invest Biosanitaria ibs GRANADA, Escuela Andaluza Salud Publ, Granada, Spain.;CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain..
    Kiechl, Stefan
    Med Univ Innsbruck, Innsbruck, Austria..
    Krumholz, Harlan M.
    Grioni, Sara
    Fdn IRCCS Ist Nazl Tumori, Epidemiol & Prevent Unit, Milan, Italy..
    Palli, Domenico
    Canc Res & Prevent Inst ISPO, Florence, Italy..
    Huerta, Jose M.
    CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain.;IMIB Arrixaca, Murcia Reg Hlth Council, Murcia, Spain..
    Price, Jackie
    Univ Edinburgh, Usher Inst, Edinburgh, Midlothian, Scotland..
    Sundström, Johan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    Arriola, Larraitz
    CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain.;Basque Govt, Inst Biodonostia, San Sebastian, Spain..
    Arima, Hisatomi
    Univ Sydney, Sydney, NSW, Australia.;Royal Prince Alfred Hosp, Sydney, NSW, Australia.;Kyushu Univ, Dept Prevent Med & Publ Hlth, Fukuoka, Japan..
    Travis, Ruth C.
    Univ Oxford, Nuffield Dept Populat Hlth, Med Sci Div, Oxford, England..
    Panagiotakos, Demosthenes B.
    Harokopio Univ, Sch Hlth Sci & Educ, Athens, Greece..
    Karakatsani, Anna
    Hellen Hlth Fdn, Athens, Greece.;Univ Athens, Athens, Greece..
    Trichopoulou, Antonia
    Hellen Hlth Fdn, Athens, Greece.;Univ Athens, Athens, Greece..
    Kuhn, Tilman
    German Canc Res Ctr, Heidelberg, Germany..
    Grobbee, Diederick E.
    Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands..
    Barrett-Connor, Elizabeth
    Univ Calif San Diego, Dept Family Med & Publ Hlth, San Diego, CA 92103 USA..
    van Schoor, Natasja
    Vrije Univ Amsterdam, Med Ctr, EMGO Inst Hlth & Care Res, Amsterdam, Netherlands..
    Boeing, Heiner
    German Inst Human Nutr, Potsdam, Germany..
    Overvad, Kim
    Aarhus Univ, Dept Publ Hlth, Aarhus, Denmark.;Aalborg Univ Hosp, Aalborg, Denmark..
    Kauhanen, Jussi
    Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland..
    Wareham, Nick
    Univ Cambridge, Med Res Council Epidemiol Unit, Cambridge, England..
    Langenberg, Claudia
    Univ Cambridge, Med Res Council Epidemiol Unit, Cambridge, England..
    Forouhi, Nita
    Univ Cambridge, Med Res Council Epidemiol Unit, Cambridge, England..
    Wennberg, Maria
    Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden..
    Despres, Jean-Pierre
    Laval Univ, Dept Kinesiol, Quebec City, PQ, Canada..
    Cushman, Mary
    Univ Vermont, Dept Med, Burlington, VT USA..
    Cooper, Jackie A.
    UCL, Dept Epidemiol & Publ Hlth, London, England..
    Rodriguez, Carlos J.
    Wake Forest Univ, Bowman Gray Sch Med, Winston Salem, NC USA.;Wake Forest Baptist Med Ctr, Winston Salem, NC USA..
    Sakurai, Masaru
    Kanazawa Med Univ, Dept Social & Environm Med, Kanazawa, Ishikawa, Japan..
    Shaw, Jonathan E.
    Baker IDI Heart & Diabet Inst, Melbourne, Vic, Australia..
    Knuiman, Matthew
    Populat Med Res Inst, Busselton, WA, Australia.;Univ Western Australia, Sch Populat & Global Hlth, Perth, WA, Australia..
    Voortman, Trudy
    Erasmus Univ, Med Ctr, Rotterdam, Netherlands..
    Meisinger, Christa
    Helmholtz Zentrum Munchen German Res Ctr Environm, Munich, Germany..
    Tjonneland, Anne
    Danish Canc Soc Res Ctr, Copenhagen, Denmark..
    Brenner, Hermann
    German Canc Res Ctr, Heidelberg, Germany.;Heidelberg Univ, Div Clin Epidemiol & Aging Res, Heidelberg, Germany..
    Palmieri, Luigi
    Ist Supe Sanita, Rome, Italy..
    Dallongeville, Jean
    Inst Pasteur, Lille, France..
    Brunner, Eric J.
    UCL, Dept Epidemiol & Publ Hlth, London, England..
    Assmann, Gerd
    Assmann Stiftung Pravent, Munster, Germany..
    Trevisan, Maurizio
    CUNY City Coll, New York, NY USA..
    Gillum, Richard F.
    Howard Univ Hosp, Washington, DC USA..
    Ford, Ian
    Univ Glasgow, Inst Cardiovasc & Med Sci, Glasgow, Lanark, Scotland..
    Sattar, Naveed
    Univ Glasgow, Inst Cardiovasc & Med Sci, Glasgow, Lanark, Scotland..
    Lazo, Mariana
    Johns Hopkins Univ, Sch Med, Baltimore, MD USA..
    Thompson, Simon G.
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England..
    Ferrari, Pietro
    Int Agcy Res Canc, Lyon, France..
    Leon, David A.
    London Sch Hyg & Trop Med, London, England..
    Smith, George Davey
    Univ Bristol, MRC Integrat Epidemiol Unit IEU, Bristol, Avon, England..
    Peto, Richard
    Jackson, Rod
    Univ Auckland, Sch Populat Hlth, Auckland, New Zealand..
    Banks, Emily
    Australian Natl Univ, Natl Ctr Epidemiol & Populat Hlth, Canberra, ACT, Australia..
    Di Angelantonio, Emanuele
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England..
    Danesh, John
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England..
    Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies2018In: The Lancet, ISSN 0140-6736, E-ISSN 1474-547X, Vol. 391, no 10129, p. 1513-1523Article in journal (Refereed)
    Abstract [en]

    Background: Low-risk limits recommended for alcohol consumption vary substantially across different national guidelines. To define thresholds associated with lowest risk for all-cause mortality and cardiovascular disease, we studied individual-participant data from 599 912 current drinkers without previous cardiovascular disease.

    Methods: We did a combined analysis of individual-participant data from three large-scale data sources in 19 high-income countries (the Emerging Risk Factors Collaboration, EPIC-CVD, and the UK Biobank). We characterised dose-response associations and calculated hazard ratios (HRs) per 100 g per week of alcohol (12.5 units per week) across 83 prospective studies, adjusting at least for study or centre, age, sex, smoking, and diabetes. To be eligible for the analysis, participants had to have information recorded about their alcohol consumption amount and status (ie, non-drinker vs current drinker), plus age, sex, history of diabetes and smoking status, at least 1 year of follow-up after baseline, and no baseline history of cardiovascular disease. The main analyses focused on current drinkers, whose baseline alcohol consumption was categorised into eight predefined groups according to the amount in grams consumed per week. We assessed alcohol consumption in relation to all-cause mortality, total cardiovascular disease, and several cardiovascular disease subtypes. We corrected HRs for estimated long-term variability in alcohol consumption using 152 640 serial alcohol assessments obtained some years apart (median interval 5.6 years [5th-95th percentile 1.04-13.5]) from 71 011 participants from 37 studies.

    Findings: In the 599 912 current drinkers included in the analysis, we recorded 40 310 deaths and 39 018 incident cardiovascular disease events during 5.4 million person-years of follow-up. For all-cause mortality, we recorded a positive and curvilinear association with the level of alcohol consumption, with the minimum mortality risk around or below 100 g per week. Alcohol consumption was roughly linearly associated with a higher risk of stroke (HR per 100 g per week higher consumption 1.14, 95% CI, 1.10-1.17), coronary disease excluding myocardial infarction (1.06, 1.00-1.11), heart failure (1.09, 1.03-1.15), fatal hypertensive disease (1.24, 1.15-1.33); and fatal aortic aneurysm (1.15, 1.03-1.28). By contrast, increased alcohol consumption was loglinearly associated with a lower risk of myocardial infarction (HR 0.94, 0.91-0.97). In comparison to those who reported drinking >0-<= 100 g per week, those who reported drinking >100-<= 200 g per week, >200-<= 350 g per week, or >350 g per week had lower life expectancy at age 40 years of approximately 6 months, 1-2 years, or 4-5 years, respectively.

    Interpretation: In current drinkers of alcohol in high-income countries, the threshold for lowest risk of all-cause mortality was about 100 g/week. For cardiovascular disease subtypes other than myocardial infarction, there were no clear risk thresholds below which lower alcohol consumption stopped being associated with lower disease risk. These data support limits for alcohol consumption that are lower than those recommended in most current guidelines.

  • 958. Woudstra, Pier
    et al.
    Grundeken, Maik J
    van de Hoef, Tim P
    Wallentin, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    Fox, Keith A
    de Winter, Robbert J
    Damman, Peter
    Prognostic relevance of PCI-related myocardial infarction2013In: Nature Reviews Cardiology, ISSN 1759-5002, E-ISSN 1759-5010, Vol. 10, no 4, p. 231-236Article in journal (Refereed)
    Abstract [en]

    Procedure-related myocardial infarction (pMI) is directly associated with a coronary revascularization procedure, such as percutaneous coronary intervention (PCI) or CABG surgery. In contrast to spontaneous myocardial infarction (MI), the prognostic relevance of pMI is the subject of ongoing debate. Data from retrospective analyses of large, randomized clinical trials, and large, contemporary cohort studies have several shortcomings that limit their extrapolation to clinical practice. In our opinion, the currently available evidence is insufficient to conclude that pMI during PCI, as currently defined, always has important prognostic implications. Until further evidence is available, we recommend adopting the definition for MI given in the third universal definition of MI, which differentiates between pMI and spontaneous MI. This is important not only for clinical decision-making but also for the interpretation of pMI as a surrogate end point in clinical trials. Further studies are essential to understand the pathophysiology and consequences of pMI.

  • 959. Wu, Alan H B
    et al.
    Packer, Milton
    Smith, Andrew
    Bijou, Rachel
    Fink, Daniel
    Mair, Johannes
    Wallentin, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
    Johnston, Nina
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    Feldcamp, Carolyn S
    Haverstick, Doris M
    Ahnadi, Charaf E
    Grant, Andrew
    Despres, Normand
    Bluestein, Barry
    Ghani, Farooq
    Analytical and clinical evaluation of the Bayer ADVIA Centaur automated B-type natriuretic peptide assay in patients with heart failure: a multisite study2004In: Clinical Chemistry, ISSN 0009-9147, E-ISSN 1530-8561, Vol. 50, no 5, p. 867-873Article in journal (Refereed)
    Abstract [en]

    BACKGROUND:

    B-Type natriuretic peptide (BNP) is released from the left ventricle of the heart into the circulation in response to ventricular stretching and volume overload. Increased BNP concentrations are associated with heart failure (HF).

    METHODS:

    We evaluated the analytical and clinical performance of the Bayer ADVIA Centaur BNP assay. Studies included precision, analytical correlation (against the Shionogi ShionoRIA and Biosite Triage BNP assays), BNP results for blood collected in plastic tubes containing EDTA vs other collection tubes, high-dose hook effect, detection limits, and interferences. The clinical performance was tested on 2243 blood samples collected from 983 apparently healthy individuals, 538 patients with chronic disease but without HF (renal insufficiency, chronic obstructive pulmonary disease, diabetes, and hypertension), and 722 patients with HF (New York Heart Association classes I-IV).

    RESULTS:

    The ADVIA Centaur assay had total imprecision (CV) of 3.4%, 2.9%, and 2.4% at BNP concentrations of 48, 461, and 1768 ng/L, respectively. The Passing-Bablok correlations to the ShionoRIA and Triage were as follows: ADVIA Centaur = 1.11(ShionoRIA) - 1.19 ng/L (r = 0.98); ADVIA Centaur = 0.78(Triage) + 5.89 ng/L (r = 0.92), respectively. Of the different blood collection tubes, only EDTA plastic tubes (with and without the barrier gel) were acceptable. The lower detection limit was 0.5 ng/L, and there were no interferences from common analytes, other neuropeptides, or unusual antibodies. BNP exhibited different reference intervals according to age and gender. BNP concentrations increased progressively as the severity of HF increased.

    CONCLUSIONS:

    The ADVIA Centaur is the first commercially available BNP assay for use on an automated immunochemistry platform. This assay has good analytical and clinical performance characteristics for diagnosing HF.

  • 960.
    Wu, Jason H. Y.
    et al.
    Univ Sydney, George Inst Global Hlth, Sydney, NSW 2050, Australia..
    Foote, Celine
    Univ Sydney, George Inst Global Hlth, Sydney, NSW 2050, Australia.;Concord Repatriat Gen Hosp, Sydney, NSW, Australia..
    Blomster, Juuso
    Univ Sydney, George Inst Global Hlth, Sydney, NSW 2050, Australia.;Univ Turku, Turku, Finland.;Univ Gothenberg, Sahlgrenska Acad, Gothenburg, Sweden..
    Toyama, Tadashi
    Univ Sydney, George Inst Global Hlth, Sydney, NSW 2050, Australia..
    Perkovic, Vlado
    Univ Sydney, George Inst Global Hlth, Sydney, NSW 2050, Australia.;Royal Prince Alfred Hosp, Sydney, NSW, Australia..
    Sundström, Johan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology. Univ Sydney, George Inst Global Hlth, Sydney, NSW 2050, Australia..
    Neal, Bruce
    Univ Sydney, George Inst Global Hlth, Sydney, NSW 2050, Australia.;Univ London Imperial Coll Sci Technol & Med, London, England..
    Effects of sodium-glucose cotransporter-2 inhibitors on cardiovascular events, death, and major safety outcomes in adults with type 2 diabetes: a systematic review and meta-analysis2016In: The Lancet Diabetes and Endocrinology, ISSN 2213-8587, E-ISSN 2213-8595, Vol. 4, no 5, p. 411-419Article in journal (Refereed)
    Abstract [en]

    Background In patients with type 2 diabetes, sodium-glucose cotransporter-2 (SGLT2) inhibitors are known to reduce glucose concentrations, blood pressure, and weight, but to increase LDL cholesterol and the incidence of urogenital infections. Protection against cardiovascular events has also been reported, as have possible increased risks of adverse outcomes such as ketoacidosis and bone fracture. We aimed to establish the effects of SGLT2 inhibitors on cardiovascular events, death, and safety outcomes in adults with type 2 diabetes, both overall and separately for individual drugs. Methods In this systematic review and meta-analysis, we searched MEDLINE, Embase, the Cochrane Library, and websites of US, European, and Japanese regulatory authorities from Jan 1, 1950, to Sept 30, 2015, for data from prospective randomised controlled trials assessing the effects of SGLT2 treatment compared with controls. We excluded duplicate reports, trials of compound drugs, trials that lasted 7 days or fewer, trials that did not report on outcomes of interest, and articles that presented pooled trial data for which the individual trials could not be identified. We extracted data in duplicate using a standardised approach. The primary outcome was major adverse cardiovascular events. Secondary outcomes were cardiovascular death, non-fatal myocardial infarction, non-fatal stroke, admission to hospital for unstable angina, heart failure, and all-cause mortality. We estimated summary relative risks with fixed-effects meta-analysis, with the I-2 statistic used to estimate heterogeneity of results beyond chance. Findings The analyses included data from six regulatory submissions (37 525 participants) and 57 published trials (33 385 participants), which provided data for seven different SGLT2 inhibitors. SGLT2 inhibitors protected against the risk of major adverse cardiovascular events (relative risk 0.84 [95% CI 0.75-0.95]; p=0.006), cardiovascular death (0.63 [0.51-0.77]; p<0.0001), heart failure (0.65 [0.50-0.85]; p=0.002), and death from any cause (0.71 [0.61-0.83]; p<0.0001). No clear effect was apparent for non-fatal myocardial infarction (0.88 [0.72-1.07]; p=0.18) or angina (0.95 [0.73-1.23]; p=0.70), but we noted an adverse effect for non-fatal stroke (1.30 [1.00-1.68]; p=0.049). We noted no clear evidence that the individual drugs had different effects on cardiovascular outcomes or death (all I I-2 < 43%). Safety analyses showed consistent increased risks of genital infections (regulatory submissions 4.75 [4.00-5.63]; scientific reports 2.88 [2.48-3.34]), but findings for some safety outcomes varied depending on whether anlayses were based on data extracted from regulatory submissions or trials reported in the scientific literature. Interpretation These data suggest net protection of SGLT2 inhibitors against cardiovascular outcomes and death. The efficacy results were driven by findings for empagliflozin (the only SGLT2 inhibitor for which data from a dedicated long-term cardiovascular safety trial have been reported), although results for the other drugs in the class were not clearly different. Adverse events were more difficult to quantify than was efficacy, with the effects of individual drugs in the class seeming to differ for some safety outcomes. Results from ongoing studies will be crucial to substantiate these findings across the drug class, but the available data provide a strong rationale to expect benefit from use of SGLT2 inhibitors in patients with type 2 diabetes at high risk of cardiovascular events.

  • 961.
    Wuttke, Matthias
    et al.
    Univ Freiburg, Fac Med, Dept Biometry Epidemiol & Med Bioinformat, Inst Genet Epidemiol, Freiburg, Germany;Univ Freiburg, Med Ctr, Freiburg, Germany;Univ Freiburg, Fac Med, Dept Med 4, Renal Div, Freiburg, Germany.
    Li, Yong
    Univ Freiburg, Fac Med, Dept Biometry Epidemiol & Med Bioinformat, Inst Genet Epidemiol, Freiburg, Germany;Univ Freiburg, Med Ctr, Freiburg, Germany.
    Li, Man
    Univ Utah, Dept Med, Div Nephrol & Hypertens, Salt Lake City, UT 84112 USA.
    Sieber, Karsten B.
    GlaxoSmithKline, Target Sci Genet, Collegeville, PA USA.
    Feitosa, Mary F.
    Washington Univ, Sch Med, Dept Genet, Div Stat Genom, St Louis, MO 63110 USA.
    Gorski, Mathias
    Univ Hosp Regensburg, Dept Nephrol, Regensburg, Germany;Univ Regensburg, Dept Genet Epidemiol, Regensburg, Germany.
    Tin, Adrienne
    Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA;Welch Ctr Prevent Epidemiol & Clin Res, Baltimore, MD USA.
    Wang, Lihua
    Washington Univ, Sch Med, Dept Genet, Div Stat Genom, St Louis, MO 63110 USA.
    Chu, Audrey Y.
    Merck & Co Inc, Genet, Kenilworth, NJ USA.
    Hoppmann, Anselm
    Univ Freiburg, Fac Med, Dept Biometry Epidemiol & Med Bioinformat, Inst Genet Epidemiol, Freiburg, Germany;Univ Freiburg, Med Ctr, Freiburg, Germany.
    Kirsten, Holger
    Univ Leipzig, Inst Med Informat Stat & Epidemiol, Leipzig, Germany;Univ Leipzig, LIFE Res Ctr Civilizat Dis, Leipzig, Germany.
    Giri, Ayush
    Vanderbilt Univ, Med Ctr,Div Quantitat Sci, Dept Obstet & Gynecol,Vanderbilt Genet Inst, Inst Med & Publ Hlth,Vanderbilt Epidemiol Ctr, Nashville, TN 37232 USA;Vanderbilt Univ, Tennessee Valley Healthcare Syst 626, Biomed Lab Res & Dev, 221 Kirkland Hall, Nashville, TN 37235 USA.
    Chai, Jin-Fang
    Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore;Natl Univ Hlth Syst, Singapore, Singapore.
    Sveinbjornsson, Gardar
    Amgen Inc, deCODE Genet, Reykjavik, Iceland.
    Tayo, Bamidele O.
    Loyola Univ Chicago, Dept Publ Hlth Sci, Maywood, IL USA.
    Nutile, Teresa
    Adriano Buzzati Traverso CNR, Inst Genet & Biophys, Naples, Italy.
    Fuchsberger, Christian
    Univ Lubeck, Inst Biomed, Eurac Res, Bolzano, Italy.
    Marten, Jonathan
    Univ Edinburgh, Inst Genet & Mol Med, Med Res Council, Human Genet Unit, Edinburgh, Midlothian, Scotland.
    Cocca, Massimiliano
    IRCCS Burlo Garofolo, Inst Maternal & Child Hlth, Trieste, Italy.
    Ghasemi, Sahar
    Univ Med Greifswald, Inst Community Med, Greifswald, Germany;DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, Greifswald, Germany.
    Xu, Yizhe
    Univ Utah, Dept Med, Div Nephrol & Hypertens, Salt Lake City, UT 84112 USA.
    Horn, Katrin
    Univ Leipzig, Inst Med Informat Stat & Epidemiol, Leipzig, Germany;Univ Leipzig, LIFE Res Ctr Civilizat Dis, Leipzig, Germany.
    Noce, Damia
    Univ Lubeck, Inst Biomed, Eurac Res, Bolzano, Italy.
    Van der Most, Peter J.
    Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands.
    Sedaghat, Sanaz
    Univ Med Ctr Rotterdam, Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.
    Yu, Zhi
    Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA;Johns Hopkins Bloomberg Sch Publ Hlth, Dept Biostat, Baltimore, MD USA.
    Akiyama, Masato
    RIKEN, Ctr Integrat Med Sci IMS, Lab Stat Anal, Yokohama, Kanagawa, Japan;Kyushu Univ, Grad Sch Med Sci, Dept Ophthalmol, Fukuoka, Fukuoka, Japan.
    Afaq, Saima
    Imperial Coll London, Sch Publ Hlth, Fac Med, Dept Epidemiol & Biostat, London, England;Khyber Med Univ, Inst Publ Hlth & Social Sci, Peshawar, Pakistan.
    Ahluwalia, Tarunveer S.
    Steno Diabet Ctr Copenhagen, Gentofte, Denmark.
    Almgren, Peter
    Lund Univ, Dept Clincial Sci Malmo, Diabetes & Cardiovasc Disease Genet Epidemi, Malmo, Sweden.
    Amin, Najaf
    Univ Med Ctr Rotterdam, Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.
    Arnlov, Johan
    Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Family Med & Primary Care, Stockholm, Sweden;Dalarna Univ, Sch Hlth & Social Studies, Stockholm, Sweden.
    Bakker, Stephan J. L.
    Univ Groningen, Univ Med Ctr Groningen, Dept Internal Med, Div Nephrol, Groningen, Netherlands.
    Bansal, Nisha
    Univ Washington, Div Nephrol, Seattle, WA 98195 USA;Univ Washington, Kidney Res Inst, Seattle, WA 98195 USA.
    Baptista, Daniela
    Geneva Univ Hosp, Cardiol, Geneva, Switzerland.
    Bergmann, Sven
    Univ Lausanne, Dept Computat Biol, Lausanne, Switzerland;Swiss Inst Bioinformat, Lausanne, Switzerland;Univ Cape Town, Dept Integrat Biomed Sci, Cape Town, South Africa.
    Biggs, Mary L.
    Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA;Univ Washington, Dept Biostat, Seattle, WA 98195 USA.
    Biino, Ginevra
    Natl Res Council Italy, Inst Mol Genet, Pavia, Italy.
    Boehnke, Michael
    Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA;Univ Michigan, Ctr Stat Genet, Ann Arbor, MI 48109 USA.
    Boerwinkle, Eric
    Univ Texas Hlth Sci Ctr Houston, Human Genet Ctr, Houston, TX 77030 USA.
    Boissel, Mathilde
    Univ Lille, Inst Pasteur Lille, CNRS, UMR 8199,EGID, Lille, France.
    Bottinger, Erwin P.
    Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA;Hasso Plattner Inst, Digital Hlth Ctr, Potsdam, Germany;Univ Potsdam, Potsdam, Germany.
    Boutin, Thibaud S.
    Univ Edinburgh, Inst Genet & Mol Med, Med Res Council, Human Genet Unit, Edinburgh, Midlothian, Scotland.
    Brenner, Hermann
    German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany;Heidelberg Univ, Network Aging Res, Heidelberg, Germany.
    Brumat, Marco
    Univ Trieste, Dept Med Surg & Hlth Sci, Trieste, Italy.
    Burkhardt, Ralph
    Univ Leipzig, LIFE Res Ctr Civilizat Dis, Leipzig, Germany;Univ Leipzig, Inst Lab Med Clin Chem & Mol Diagnost, Leipzig, Germany;Univ Hosp Regensburg, Inst Clin Chem & Lab Med, Regensburg, Germany.
    Butterworth, Adam S.
    Univ Cambridge, Dept Publ Hlth & Primary Care, MRC BHF Cardiovasc Epidemiol Unit, Cambridge, England;Univ Cambridge, Natl Inst Hlth Res Blood & Transplant Res Unit Do, Cambridge, England.
    Campana, Eric
    Univ Trieste, Dept Med Surg & Hlth Sci, Trieste, Italy.
    Campbell, Archie
    Univ Edinburgh, Inst Genet & Mol Med, Ctr Genom & Expt Med, Edinburgh, Midlothian, Scotland.
    Campbell, Harry
    Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Ctr Global Hlth Res, Edinburgh, Midlothian, Scotland.
    Canouil, Mickael
    Univ Lille, Inst Pasteur Lille, CNRS, UMR 8199,EGID, Lille, France.
    Carroll, Robert J.
    Vanderbilt Univ, Med Ctr, Dept Biomed Informat, Nashville, TN USA.
    Catamo, Eulalia
    IRCCS Burlo Garofolo, Inst Maternal & Child Hlth, Trieste, Italy.
    Chambers, John C.
    Imperial Coll London, Sch Publ Hlth, Fac Med, Dept Epidemiol & Biostat, London, England;Nanyang Technol Univ, Lee Kong Chian Sch Med, Singapore, Singapore;Ealing Gen Hosp, Dept Cardiol, Middlesex, England;Imperial Coll London, Imperial Coll Healthcare NHS Trust, London, England;Imperial Coll London, Sch Publ Hlth, MRC PHE Ctr Environm & Hlth, London, England.
    Chee, Miao-Ling
    Singapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore, Singapore.
    Chee, Miao-Li
    Singapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore, Singapore.
    Chen, Xu
    Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
    Cheng, Ching-Yu
    Natl Univ Hlth Syst, Singapore, Singapore;Singapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore, Singapore;Duke NUS Med Sch, Ophthalmol & Visual Sci Acad Clin Program Eye ACP, Singapore, Singapore;Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Ophthalmol, Singapore, Singapore.
    Cheng, Yurong
    Univ Freiburg, Fac Med, Dept Biometry Epidemiol & Med Bioinformat, Inst Genet Epidemiol, Freiburg, Germany;Univ Freiburg, Med Ctr, Freiburg, Germany.
    Christensen, Kaare
    Southern Denmark Univ, Dept Publ Hlth, Unit Epidemiol Biostat & Biodemog, Odense, Denmark.
    Cifkova, Renata
    Charles Univ Prague, Fac Med 1, Ctr Cardiovasc Prevent, Prague, Czech Republic;Thomayer Hosp, Prague, Czech Republic;Charles Univ Prague, Fac Med 1, Dept Med 2, Prague, Czech Republic.
    Ciullo, Marina
    Adriano Buzzati Traverso CNR, Inst Genet & Biophys, Naples, Italy;IRCCS Neuromed, Pozzilli, Italy.
    Concas, Maria Pina
    IRCCS Burlo Garofolo, Inst Maternal & Child Hlth, Trieste, Italy.
    Cook, James P.
    Univ Liverpool, Dept Biostat, Liverpool, Merseyside, England.
    Coresh, Josef
    Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA.
    Corre, Tanguy
    Univ Lausanne, Dept Computat Biol, Lausanne, Switzerland;Swiss Inst Bioinformat, Lausanne, Switzerland;Lausanne Univ Hosp, Inst Social & Prevent Med, Lausanne, Switzerland.
    Sala, Cinzia Felicita
    San Raffaele Res Inst, Milan, Italy.
    Cusi, Daniele
    Natl Res Council Italy, Inst Biomed Technol, Milan, Italy;Bio4Dreams Business Nursery Life Sci, Milan, Italy.
    Danesh, John
    Univ Cambridge, Sch Clin Med, Dept Publ Hlth & Primary Care, Cambridge, England.
    Daw, E. Warwick
    Washington Univ, Sch Med, Dept Genet, Div Stat Genom, St Louis, MO 63110 USA.
    De Borst, Martin H.
    Univ Groningen, Univ Med Ctr Groningen, Dept Internal Med, Div Nephrol, Groningen, Netherlands.
    De Grandi, Alessandro
    Univ Lubeck, Inst Biomed, Eurac Res, Bolzano, Italy.
    De Mutsert, Renee
    Leiden Univ, Med Ctr, Dept Clin Epidemiol, Leiden, Netherlands.
    De Vries, Aiko P. J.
    Leiden Univ, Med Ctr, Dept Internal Med, Sect Nephrol, Leiden, Netherlands.
    Degenhardt, Frauke
    Christian Albrechts Univ Kiel, Inst Clin Mol Biol, Kiel, Germany.
    Delgado, Graciela
    Heidelberg Univ, Med Fac Mannheim, Dept Med, Nephrol,Hypertensiol,Rheumatol,Endocrinol,Diabet, Mannheim, Germany.
    Demirkan, Ayse
    Univ Med Ctr Rotterdam, Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.
    Di Angelantonio, Emanuele
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England;NHS Blood & Transplant, Cambridge, England.
    Dittrich, Katalin
    Univ Leipzig, Hosp Children & Adolescents, Dept Women & Child Hlth, Leipzig, Germany;Univ Leipzig, Ctr Pediat Res, Leipzig, Germany.
    Divers, Jasmin
    Wake Forest Sch Med, Publ Hlth Sci Biostat, Winston Salem, NC USA.
    Dorajoo, Rajkumar
    Agcy Sci Technol & Res, Genome Inst Singapore, Singapore, Singapore.
    Eckardt, Kai-Uwe
    Charite, Intens Care Med, Berlin, Germany;Friedrich Alexander Univ Erlangen Nurnberg FAU, Dept Nephrol & Hypertens, Erlangen, Germany.
    Ehret, Georg
    Geneva Univ Hosp, Cardiol, Geneva, Switzerland.
    Elliott, Paul
    Imperial Coll London, Sch Publ Hlth, MRC PHE Ctr Environm & Hlth, Dept Epidemiol & Biostat, London, England;Imperial Coll London, Imperial Coll, NIHR Biomed Res Ctr, London, England;Imperial Coll London, Dementia Res Inst, London, England;Hlth Data Res UK London, London, England.
    Endlich, Karlhans
    DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, Greifswald, Germany;Univ Med Greifswald, Dept Anat & Cell Biol, Greifswald, Germany.
    Evans, Michele K.
    NIA, Lab Epidemiol & Populat Sci, Intramural Res Program, US NIH, Baltimore, MD 21224 USA.
    Felix, Janine F.
    Univ Med Ctr Rotterdam, Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands;Univ Med Ctr Rotterdam, Erasmus MC, Generat R Study Grp, Rotterdam, Netherlands;Univ Med Ctr Rotterdam, Erasmus MC, Dept Pediat, Rotterdam, Netherlands.
    Foo, Valencia Hui Xian
    Singapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore, Singapore.
    Franco, Oscar H.
    Univ Med Ctr Rotterdam, Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands;Univ Bern, ISPM, Bern, Switzerland.
    Franke, Andre
    Christian Albrechts Univ Kiel, Inst Clin Mol Biol, Kiel, Germany.
    Freedman, Barry I.
    Wake Forest Sch Med, Internal Med, Sect Nephrol, Winston Salem, NC USA.
    Freitag-Wolf, Sandra
    Univ Kiel, Univ Hosp Schleswig Holstein, Inst Med Informat & Stat, Kiel, Germany.
    Friedlander, Yechiel
    Hebrew Univ Jerusalem, Sch Publ Hlth & Community Med, Jerusalem, Israel.
    Froguel, Philippe
    Univ Lille, Inst Pasteur Lille, CNRS, UMR 8199,EGID, Lille, France;Imperial Coll London, Dept Genom Common Dis, London, England.
    Gansevoort, Ron T.
    Univ Groningen, Univ Med Ctr Groningen, Dept Internal Med, Div Nephrol, Groningen, Netherlands.
    Gao, He
    Imperial Coll London, Sch Publ Hlth, MRC PHE Ctr Environm & Hlth, Dept Epidemiol & Biostat, London, England.
    Gasparini, Paolo
    IRCCS Burlo Garofolo, Inst Maternal & Child Hlth, Trieste, Italy;Univ Trieste, Dept Med Surg & Hlth Sci, Trieste, Italy.
    Gaziano, J. Michael
    VA Boston Healthcare Syst, VA Cooperat Studies Program, Massachusetts Vet Epidemiol Res & Informat Ctr, Boston, MA USA.
    Giedraitis, Vilmantas
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
    Gieger, Christian
    German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, Neuherberg, Germany;German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol, Neuherberg, Germany;German Ctr Diabet Res DZD, Neuherberg, Germany.
    Girotto, Giorgia
    IRCCS Burlo Garofolo, Inst Maternal & Child Hlth, Trieste, Italy;Univ Trieste, Dept Med Surg & Hlth Sci, Trieste, Italy.
    Giulianini, Franco
    Brigham & Womens Hosp, Div Prevent Med, 75 Francis St, Boston, MA 02115 USA.
    Gogele, Martin
    Univ Lubeck, Inst Biomed, Eurac Res, Bolzano, Italy.
    Gordon, Scott D.
    QIMR Berghofer Med Res Inst, Brisbane, Qld, Australia.
    Gudbjartsson, Daniel F.
    Amgen Inc, deCODE Genet, Reykjavik, Iceland.
    Gudnason, Vilmundur
    Iceland Heart Assoc, Kopavogur, Iceland;Univ Iceland, Sch Hlth Sci, Fac Med, Reykjavik, Iceland.
    Haller, Toomas
    Univ Tartu, Inst Genom, Estonian Genome Ctr, Tartu, Estonia.
    Hamet, Pavel
    CHUM, Montreal Univ Hosp, Res Ctr, Montreal, PQ, Canada;Medpharmgene, Montreal, PQ, Canada.
    Harris, Tamara B.
    NIA, Lab Epidemiol & Populat Sci, Intramural Res Program, US NIH, Bethesda, MD 20892 USA.
    Hartman, Catharina A.
    Univ Groningen, Univ Med Ctr Groningen, nterdisciplinary Ctr Psychopathol & Emot Regulat, Groningen, Netherlands.
    Hayward, Caroline
    Univ Edinburgh, Inst Genet & Mol Med, Med Res Council, Human Genet Unit, Edinburgh, Midlothian, Scotland.
    Hellwege, Jacklyn N.
    Vanderbilt Univ, Med Ctr, Vanderbilt Genet Inst, Nashville, TN USA;Vanderbilt Univ, Med Ctr, Dept Med, Div Epidemiol,Vanderbilt Genet Inst, Nashville, TN 37232 USA;Vanderbilt Univ, Tennessee Valley Healthcare Syst 626, Dept Vet Affairs, 221 Kirkland Hall, Nashville, TN 37235 USA.
    Heng, Chew-Kiat
    Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Paediat, Singapore, Singapore;Natl Univ Hlth Syst, Khoo Teck Puat Natl Univ, Childrens Med Inst, Singapore, Singapore.
    Hicks, Andrew A.
    Univ Lubeck, Inst Biomed, Eurac Res, Bolzano, Italy.
    Hofer, Edith
    Med Univ Graz, Dept Neurol, Clin Div Neurogeriatr, Graz, Austria;Med Univ Graz, Inst Med Informat Stat & Documentat, Graz, Austria.
    Huang, Wei
    Chinese Natl Human Genome Ctr, Shanghai MOST Key Lab Hlth & Dis Genom, Dept Genet, Shanghai, Peoples R China;Shanghai Ind Technol Inst, Shanghai, Peoples R China.
    Hutri-Kahonen, Nina
    Tampere Univ Hosp, Dept Pediat, Tampere, Finland;Univ Tampere, Fac Med & Life Sci, Dept Pediat, Tampere, Finland.
    Hwang, Shih-Jen
    NHLBIs Framingham Heart Study, Framingham, MA USA;NHLBI, Ctr Populat Studies, Framingham, MA USA.
    Ikram, M. Arfan
    Univ Med Ctr Rotterdam, Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.
    Indridason, Olafur S.
    Natl Univ Hosp Iceland, Landspitali, Internal Med Serv, Div Nephrol, Reykjavik, Iceland.
    Ingelsson, Erik
    Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology. Stanford Univ, Dept Med, Sch Med, Div Cardiovasc Med, Stanford, CA 94305 USA;Stanford Univ, Stanford Cardiovasc Inst, Stanford, CA 94305 USA;Stanford Univ, Stanford Diabet Res Ctr, Stanford, CA 94305 USA.
    Ising, Marcus
    Max Planck Inst Psychiat, Munich, Germany.
    Jaddoe, Vincent W. V.
    Univ Med Ctr Rotterdam, Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands;Charles Univ Prague, Fac Med 1, Ctr Cardiovasc Prevent, Prague, Czech Republic;Thomayer Hosp, Prague, Czech Republic;Univ Med Ctr Rotterdam, Erasmus MC, Dept Pediat, Rotterdam, Netherlands.
    Jakobsdottir, Johanna
    Univ Iceland, Ctr Publ Hlth Sci, Reykjavik, Iceland.
    Jonas, Jost B.
    Heidelberg Univ, Med Fac Mannheim, Dept Ophthalmol, Mannheim, Germany;Capital Med Univ, Beijing Tongren Hosp, Beijing Key Lab Ophthalmol & Visual Sci, Beijing Inst Ophthalmol, Beijing, Peoples R China.
    Joshi, Peter K.
    Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Ctr Global Hlth Res, Edinburgh, Midlothian, Scotland.
    Josyula, Navya Shilpa
    Biomed & Translat Informat Inst, Geisinger Res, Rockville, MD USA.
    Jung, Bettina
    Univ Hosp Regensburg, Dept Nephrol, Regensburg, Germany.
    Kahonen, Mika
    Tampere Univ Hosp, Dept Clin Physiol, Tampere, Finland;Tampere Univ, Fac Med & Hlth Technol, Finnish Cardiovasc Res Ctr Tampere, Dept Clin Physiol, Tampere, Finland.
    Kamatani, Yoichiro
    RIKEN, Ctr Integrat Med Sci IMS, Lab Stat Anal, Yokohama, Kanagawa, Japan;Kyoto Univ, Grad Sch Med, Kyoto McGill Int Collaborat Sch Genom Med, Kyoto, Japan.
    Kammerer, Candace M.
    Univ Pittsburgh, Grad Sch Publ Hlth, Dept Human Genet, Pittsburgh, PA 15261 USA.
    Kanai, Masahiro
    RIKEN, Ctr Integrat Med Sci IMS, Lab Stat Anal, Yokohama, Kanagawa, Japan;Harvard Med Sch, Dept Biomed Informat, Boston, MA 02115 USA.
    Kastarinen, Mika
    Kuopio Univ Hosp, Dept Med, Kuopio, Finland.
    Kerr, Shona M.
    Univ Edinburgh, Inst Genet & Mol Med, Med Res Council, Human Genet Unit, Edinburgh, Midlothian, Scotland.
    Khor, Chiea-Chuen
    Singapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore, Singapore;Agcy Sci Technol & Res, Genome Inst Singapore, Singapore, Singapore.
    Kiess, Wieland
    Univ Leipzig, LIFE Res Ctr Civilizat Dis, Leipzig, Germany;Univ Leipzig, Hosp Children & Adolescents, Dept Women & Child Hlth, Leipzig, Germany;Univ Leipzig, Ctr Pediat Res, Leipzig, Germany.
    Kleber, Marcus E.
    Heidelberg Univ, Med Fac Mannheim, Dept Med, Nephrol,Hypertensiol,Rheumatol,Endocrinol,Diabet, Mannheim, Germany.
    Koenig, Wolfgang
    Tech Univ Munich, Deutsches Herzzentrum Munchen, Munich, Germany;DZHK German Ctr Cardiovasc Res, Partner Site Munich Heart Alliance, Munich, Germany;Univ Ulm, Inst Epidemiol & Biostat, Ulm, Germany.
    Kooner, Jaspal S.
    Ealing Gen Hosp, Dept Cardiol, Middlesex, England;Imperial Coll London, Imperial Coll Healthcare NHS Trust, London, England;Imperial Coll London, Sch Publ Hlth, MRC PHE Ctr Environm & Hlth, London, England;Imperial Coll London, Natl Heart & Lung Inst, London, England.
    Korner, Antje
    Univ Leipzig, LIFE Res Ctr Civilizat Dis, Leipzig, Germany;Univ Leipzig, Hosp Children & Adolescents, Dept Women & Child Hlth, Leipzig, Germany;Univ Leipzig, Ctr Pediat Res, Leipzig, Germany.
    Kovacs, Peter
    Univ Leipzig, Integrated Res & Treatment Ctr Adipos Dis, Leipzig, Germany.
    Kraja, Aldi T.
    Washington Univ, Sch Med, Dept Genet, Div Stat Genom, St Louis, MO 63110 USA.
    Krajcoviechova, Alena
    Charles Univ Prague, Fac Med 1, Ctr Cardiovasc Prevent, Prague, Czech Republic;Thomayer Hosp, Prague, Czech Republic;Charles Univ Prague, Fac Med 1, Dept Med 2, Prague, Czech Republic.
    Kramer, Holly
    Loyola Univ Chicago, Dept Publ Hlth Sci, Maywood, IL USA;Loyola Univ, Div Nephrol & Hypertens, Chicago, IL 60611 USA.
    Kramer, Bernhard K.
    Heidelberg Univ, Med Fac Mannheim, Dept Med, Nephrol,Hypertensiol,Rheumatol,Endocrinol,Diabet, Mannheim, Germany.
    Kronenberg, Florian
    Med Univ Innsbruck, Dept Med Genet Mol & Clin Pharmacol, Div Genet Epidemiol, Innsbruck, Austria.
    Kubo, Michiaki
    RIKEN, Ctr Integrat Med Sci IMS, Yokohama, Kanagawa, Japan.
    Kuhnel, Brigitte
    German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, Neuherberg, Germany.
    Kuokkanen, Mikko
    Natl Inst Hlth & Welf, Dept Publ Hlth Solut, Helsinki, Finland;Univ Helsinki, Diabet & Obes Res Program, Helsinki, Finland.
    Kuusisto, Johanna
    Kuopio Univ Hosp, Dept Med, Kuopio, Finland;Univ Eastern Finland, Internal Med, Inst Clin Med, Kuopio, Finland.
    La Bianca, Martina
    IRCCS Burlo Garofolo, Inst Maternal & Child Hlth, Trieste, Italy.
    Laakso, Markku
    Kuopio Univ Hosp, Dept Med, Kuopio, Finland;Univ Eastern Finland, Internal Med, Inst Clin Med, Kuopio, Finland.
    Lange, Leslie A.
    Univ Colorado Denver, Sch Med, Div Biomed Informat & Personalized Med, Anschutz Med Campus, Aurora, CO USA.
    Langefeld, Carl D.
    Wake Forest Sch Med, Publ Hlth Sci Biostat, Winston Salem, NC USA.
    Lee, Jeannette Jen-Mai
    Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore;Natl Univ Hlth Syst, Singapore, Singapore.
    Lehne, Benjamin
    Imperial Coll London, Sch Publ Hlth, Fac Med, Dept Epidemiol & Biostat, London, England.
    Lehtimaki, Terho
    Fimlab Labs, Dept Clin Chem, Tampere, Finland;Univ Tampere, Fac Med & Life Sci, Finnish Cardiovasc Res Ctr Tampere, Dept Clin Chem, Tampere, Finland.
    Lieb, Wolfgang
    Univ Kiel, Inst Epidemiol & Biobank Popgen, Kiel, Germany.
    Lim, Su-Chi
    Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore;Natl Univ Hlth Syst, Singapore, Singapore;Khoo Teck Puat Hosp, Diabet Ctr, Singapore, Singapore.
    Lind, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Epidemiology.
    Lindgren, Cecilia M.
    Univ Oxford, Nuffield Dept Med, Oxford, England;Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.
    Liu, Jun
    Univ Med Ctr Rotterdam, Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.
    Liu, Jianjun
    Natl Univ Hlth Syst, Singapore, Singapore;Agcy Sci Technol & Res, Genome Inst Singapore, Singapore, Singapore;Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore, Singapore.
    Loeffler, Markus
    Univ Leipzig, Inst Med Informat Stat & Epidemiol, Leipzig, Germany;Univ Leipzig, LIFE Res Ctr Civilizat Dis, Leipzig, Germany.
    Loos, Ruth J. F.
    Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA;Icahn Sch Med Mt Sinai, Mindich Child Hlth & Dev Inst, New York, NY 10029 USA.
    Lucae, Susanne
    Max Planck Inst Psychiat, Munich, Germany.
    Lukas, Mary Ann
    GlaxoSmithKline, Target Sci Genet, Albuquerque, NM USA.
    Lyytikainen, Leo-Pekka
    Fimlab Labs, Dept Clin Chem, Tampere, Finland;Univ Tampere, Fac Med & Life Sci, Finnish Cardiovasc Res Ctr Tampere, Dept Clin Chem, Tampere, Finland.
    Magi, Reedik
    Univ Tartu, Inst Genom, Estonian Genome Ctr, Tartu, Estonia.
    Magnusson, Patrik K. E.
    Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
    Mahajan, Anubha
    Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England;Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.
    Martin, Nicholas G.
    QIMR Berghofer Med Res Inst, Brisbane, Qld, Australia.
    Martins, Jade
    Max Planck Inst Psychiat, Dept Translat Res Psychiat, Munich, Germany.
    Marz, Winfried
    Synlab Holding Deutschland GmbH, Synlab Acad, Mannheim, Germany;Med Univ Graz, Clin Inst Med & Chem Lab Diagnost, Graz, Austria;Heidelberg Univ, Med Fac Mannheim, Med Clin 5, Mannheim, Germany.
    Mascalzoni, Deborah
    Univ Lubeck, Inst Biomed, Eurac Res, Bolzano, Italy.
    Matsuda, Koichi
    Univ Tokyo, Grad Sch Frontier Sci, Lab Clin Genome Sequencing, Tokyo, Japan.
    Meisinger, Christa
    German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Independent Res Grp Clin Epidemiol, Neuherberg, Germany;Ludwig Maximilians Univ Munchen, UNIKA T Augsburg, Chair Epidemiol, Augsburg, Germany.
    Meitinger, Thomas
    DZHK German Ctr Cardiovasc Res, Partner Site Munich Heart Alliance, Munich, Germany;Helmholtz Zentrum Munchen, Inst Human Genet, Neuherberg, Germany;Tech Univ Munich, Inst Human Genet, Munich, Germany.
    Melander, Olle
    Lund Univ, Dept Clincial Sci Malmo, Hypertens & Cardiovasc Dis, Malmo, Sweden.
    Metspalu, Andres
    Univ Tartu, Inst Genom, Estonian Genome Ctr, Tartu, Estonia.
    Mikaelsdottir, Evgenia K.
    Amgen Inc, deCODE Genet, Reykjavik, Iceland.
    Milaneschi, Yuri
    Vrije Univ Amsterdam, Med Ctr, Dept Psychiat, Amsterdam, Netherlands.
    Miliku, Kozeta
    Univ Med Ctr Rotterdam, Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands;Univ Med Ctr Rotterdam, Erasmus MC, Generat R Study Grp, Rotterdam, Netherlands;Univ Med Ctr Rotterdam, Erasmus MC, Dept Pediat, Rotterdam, Netherlands.
    Mishra, Pashupati P.
    Fimlab Labs, Dept Clin Chem, Tampere, Finland;Univ Tampere, Fac Med & Life Sci, Finnish Cardiovasc Res Ctr Tampere, Dept Clin Chem, Tampere, Finland.
    Program, V. A. Million Veteran
    Univ Freiburg, Fac Med, Dept Biometry Epidemiol & Med Bioinformat, Inst Genet Epidemiol, Freiburg, Germany;Univ Freiburg, Med Ctr, Freiburg, Germany.
    Mohlke, Karen L.
    Univ N Carolina, Dept Genet, Chapel Hill, NC 27515 USA.
    Mononen, Nina
    Fimlab Labs, Dept Clin Chem, Tampere, Finland;Univ Tampere, Fac Med & Life Sci, Finnish Cardiovasc Res Ctr Tampere, Dept Clin Chem, Tampere, Finland.
    Montgomery, Grant W.
    Univ Queensland, Inst Mol Biosci, St Lucia, Qld, Australia.
    Mook-Kanamori, Dennis O.
    Leiden Univ, Med Ctr, Dept Clin Epidemiol, Leiden, Netherlands;Leiden Univ, Med Ctr, Dept Publ Hlth & Primary Care, Leiden, Netherlands.
    Mychaleckyj, Josyf C.
    Univ Virginia, Ctr Publ Hlth Genom, Charlottesville, VA USA.
    Nadkarni, Girish N.
    Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA;Icahn Sch Med Mt Sinai, Dept Med, Div Nephrol, New York, NY 10029 USA.
    Nalls, Mike A.
    NIA, Lab Neurogenet, NIH, Bethesda, MD 20892 USA;Data Tecn Int, Glen Echo, MD USA.
    Nauck, Matthias
    DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, Greifswald, Germany;Univ Med Greifswald, Inst Clin Chem & Lab Med, Greifswald, Germany.
    Nikus, Kjell
    Tampere Univ Hosp, Heart Ctr, Dept Cardiol, Tampere, Finland;Tampere Univ, Fac Med & Life Sci, Finnish Cardiovasc Res Ctr Tampere, Dept Cardiol, Tampere, Finland.
    Ning, Boting
    Boston Univ, Sch Med, Dept Biostat, Boston, MA 02118 USA.
    Nolte, Ilja M.
    Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands.
    Noordam, Raymond
    Leiden Univ, Med Ctr, Dept Internal Med, Sect Gerontol & Geriatr, Leiden, Netherlands.
    O'Connell, Jeffrey
    Univ Maryland, Sch Med, Baltimore, MD 21201 USA.
    O'Donoghue, Michelle L.
    Brigham & Womens Hosp, Div Cardiovasc, 75 Francis St, Boston, MA 02115 USA;TIMI Study Grp, Boston, MA USA.
    Olafsson, Isleifur
    Landspitali Univ Hosp, Dept Clin Biochem, Reykjavik, Iceland.
    Oldehinkel, Albertine J.
    Univ Groningen, Univ Med Ctr Groningen, nterdisciplinary Ctr Psychopathol & Emot Regulat, Groningen, Netherlands.
    Orho-Melander, Marju
    Lund Univ, Dept Clincial Sci Malmo, Diabetes & Cardiovasc Disease Genet Epidemi, Malmo, Sweden.
    Ouwehand, Willem H.
    Univ Cambridge, Sch Clin Med, Dept Publ Hlth & Primary Care, Cambridge, England.
    Padmanabhan, Sandosh
    Univ Glasgow, Inst Cardiovasc & Med Sci, Glasgow, Lanark, Scotland.
    Palmer, Nicholette D.
    Wake Forest Sch Med, Biochem, Winston Salem, NC USA.
    Palsson, Runolfur
    Univ Iceland, Sch Hlth Sci, Fac Med, Reykjavik, Iceland;Natl Univ Hosp Iceland, Landspitali, Internal Med Serv, Div Nephrol, Reykjavik, Iceland.
    Penninx, Brenda W. J. H.
    Vrije Univ Amsterdam, Med Ctr, Dept Psychiat, Amsterdam, Netherlands.
    Perls, Thomas
    Boston Univ, Sch Med, Dept Med, Geriatr Sect,Boston Med Ctr, Boston, MA 02118 USA.
    Perola, Markus
    Natl Inst Hlth & Welf, Helsinki, Finland.
    Pirastu, Mario
    UOS Sassari, Natl Res Council Italy, Inst Genet & Biomed Res, Sassari, Italy.
    Pirastu, Nicola
    Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Ctr Global Hlth Res, Edinburgh, Midlothian, Scotland.
    Pistis, Giorgio
    Univ Hosp Lausanne, Dept Psychiat, Lausanne, Switzerland.
    Podgornaia, Anna I.
    Merck & Co Inc, Genet, Kenilworth, NJ USA.
    Polasek, Ozren
    Univ Split, Fac Med, Split, Croatia;Gen Info Ltd, Zagreb, Croatia.
    Ponte, Belen
    Geneva Univ Hosp, Serv Nephrol, Geneva, Switzerland.
    Porteous, David J.
    Univ Edinburgh, Inst Genet & Mol Med, Ctr Genom & Expt Med, Edinburgh, Midlothian, Scotland;Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh, Midlothian, Scotland.
    Poulain, Tanja
    Univ Leipzig, LIFE Res Ctr Civilizat Dis, Leipzig, Germany.
    Pramstaller, Peter P.
    Univ Lubeck, Inst Biomed, Eurac Res, Bolzano, Italy.
    Preuss, Michael H.
    Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA.
    Prins, Bram P.
    Univ Cambridge, Dept Publ Hlth & Primary Care, MRC BHF Cardiovasc Epidemiol Unit, Cambridge, England.
    Province, Michael A.
    Washington Univ, Sch Med, Dept Genet, Div Stat Genom, St Louis, MO 63110 USA.
    Rabelink, Ton J.
    Leiden Univ, Med Ctr, Dept Internal Med, Sect Nephrol, Leiden, Netherlands;Leiden Univ, Med Ctr, Einthoven Lab Expt Vasc Res, Leiden, Netherlands.
    Raffield, Laura M.
    Univ N Carolina, Dept Genet, Chapel Hill, NC 27515 USA.
    Raitakari, Olli T.
    Turku Univ Hosp, Dept Clin Physiol & Nucl Med, Turku, Finland;Univ Turku, Res Ctr Appl & Prevent Cardiovasc Med, Turku, Finland.
    Reilly, Dermot F.
    Merck & Co Inc, Genet, Kenilworth, NJ USA.
    Rettig, Rainer
    Univ Med Greifswald, Inst Physiol, Karlsburg, Germany.
    Rheinberger, Myriam
    Univ Hosp Regensburg, Dept Nephrol, Regensburg, Germany.
    Rice, Kenneth M.
    Univ Washington, Dept Biostat, Seattle, WA 98195 USA.
    Ridker, Paul M.
    Brigham & Womens Hosp, Div Prevent Med, 75 Francis St, Boston, MA 02115 USA;Harvard Med Sch, Boston, MA 02115 USA.
    Rivadeneira, Fernando
    Univ Med Ctr Rotterdam, Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands;Univ Med Ctr Rotterdam, Erasmus MC, Dept Internal Med, Rotterdam, Netherlands.
    Rizzi, Federica
    Univ Milan, Dept Hlth Sci, Milan, Italy;ePhood SRL, ePhood Sci Unit, Milan, Italy.
    Roberts, David J.
    BRC Oxford Haematol Theme, NHS Blood & Transplant, Oxford, England;Nuffield Div Clin Lab Sci, Oxford, England;Univ Oxford, Oxford, England.
    Robino, Antonietta
    IRCCS Burlo Garofolo, Inst Maternal & Child Hlth, Trieste, Italy.
    Rossing, Peter
    Steno Diabet Ctr Copenhagen, Gentofte, Denmark.
    Rudan, Igor
    Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Ctr Global Hlth Res, Edinburgh, Midlothian, Scotland.
    Rueedi, Rico
    Univ Lausanne, Dept Computat Biol, Lausanne, Switzerland;Swiss Inst Bioinformat, Lausanne, Switzerland.
    Ruggiero, Daniela
    Adriano Buzzati Traverso CNR, Inst Genet & Biophys, Naples, Italy;IRCCS Neuromed, Pozzilli, Italy.
    Ryan, Kathleen A.
    Univ Maryland, Sch Med, Div Endocrinol Diabet & Nutr, Baltimore, MD 21201 USA.
    Saba, Yasaman
    Med Univ Graz, Gottfried Schatz Res Ctr Cell Signaling Metab & A, Mol Biol & Biochem, Graz, Austria.
    Sabanayagam, Charumathi
    Singapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore, Singapore.
    Salomaa, Veikko
    Natl Inst Hlth & Welf, Helsinki, Finland.
    Salvi, Erika
    Univ Milan, Dept Hlth Sci, Milan, Italy;Fdn IRCCS Ist Neurol Carlo Besta, Neuroalgol Unit, Milan, Italy.
    Saum, Kai-Uwe
    German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany.
    Schmidt, Helena
    Med Univ Graz, Inst Mol Biol & Biochem, Ctr Mol Med, Graz, Austria.
    Schmidt, Reinhold
    Med Univ Graz, Dept Neurol, Clin Div Neurogeriatr, Graz, Austria.
    Schottker, Ben
    Schulz, Christina-Alexandra
    Lund Univ, Dept Clincial Sci Malmo, Diabetes & Cardiovasc Disease Genet Epidemi, Malmo, Sweden.
    Schupf, Nicole
    Columbia Univ, Dept Neurol, Coll Physicians & Surg, New York, NY USA;Columbia Univ, Gertrude H Sergievsky Ctr, Med Ctr, New York, NY 10027 USA;Columbia Univ, Med Ctr, Taub Inst Res Alzheimers Dis & Aging Brain, New York, NY USA.
    Shaffer, Christian M.
    Vanderbilt Univ, Med Ctr, Dept Biomed Informat, Nashville, TN USA.
    Shi, Yuan
    Singapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore, Singapore.
    Smith, Albert V.
    Univ Iceland, Sch Hlth Sci, Fac Med, Reykjavik, Iceland.
    Smith, Blair H.
    Univ Dundee, Ninewells Hosp & Med Sch, Div Populat Hlth & Genom, Dundee, Scotland.
    Soranzo, Nicole
    Wellcome Sanger Inst, Human Genet, Hinxton, England.
    Spracklen, Cassandra N.
    Univ N Carolina, Dept Genet, Chapel Hill, NC 27515 USA.
    Strauch, Konstantin
    German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Genet Epidemiol, Neuherberg, Germany;Ludwig Maximilians Univ Munchen, Fac Med, IBE, Chair Genet Epidemiol, Munich, Germany.
    Stringham, Heather M.
    Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA;Univ Michigan, Ctr Stat Genet, Ann Arbor, MI 48109 USA.
    Stumvoll, Michael
    Univ Leipzig, Dept Endocrinol & Nephrol, Leipzig, Germany.
    Svensson, Per O.
    Karolinska Inst, Sodersjukhuset, Dept Clin Sci & Educ, Stockholm, Sweden;Soder Sjukhuset, Dept Cardiol, Stockholm, Sweden.
    Szymczak, Silke
    Univ Kiel, Univ Hosp Schleswig Holstein, Inst Med Informat & Stat, Kiel, Germany.
    Tai, E-Shyong
    Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore;Natl Univ Hlth Syst, Singapore, Singapore;Natl Univ Hlth Syst, Singapore, Singapore;Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore, Singapore;Duke NUS Med Sch, Singapore, Singapore.
    Tajuddin, Salman M.
    NIA, Lab Epidemiol & Populat Sci, Intramural Res Program, US NIH, Baltimore, MD 21224 USA.
    Tan, Nicholas Y. Q.
    Singapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore, Singapore.
    Taylor, Kent D.
    Harbor UCLA Med Ctr, Los Angeles Biomed Res Inst, Dept Pediat, Inst Translat Genom & Populat Sci, Torrance, CA 90509 USA.
    Teren, Andrej
    Univ Leipzig, LIFE Res Ctr Civilizat Dis, Leipzig, Germany;Heart Ctr Leipzig, Leipzig, Germany.
    Tham, Yih-Chung
    Singapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore, Singapore.
    Thiery, Joachim
    Univ Leipzig, LIFE Res Ctr Civilizat Dis, Leipzig, Germany;Univ Leipzig, Inst Lab Med Clin Chem & Mol Diagnost, Leipzig, Germany.
    Thio, Chris H. L.
    Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands.
    Thomsen, Hauke
    German Canc Res Ctr, Div Mol Genet Epidemiol, Heidelberg, Germany.
    Thorleifsson, Gudmar
    Amgen Inc, deCODE Genet, Reykjavik, Iceland.
    Toniolo, Daniela
    San Raffaele Res Inst, Milan, Italy.
    Tonjes, Anke
    Univ Leipzig, Dept Endocrinol & Nephrol, Leipzig, Germany.
    Tremblay, Johanne
    CHUM, Montreal Univ Hosp, Res Ctr, Montreal, PQ, Canada;CRCHUM, Montreal, PQ, Canada.
    Tzoulaki, Ioanna
    Imperial Coll London, Sch Publ Hlth, MRC PHE Ctr Environm & Hlth, Dept Epidemiol & Biostat, London, England;Univ Ioannina, Med Sch, Dept Hyg & Epidemiol, Ioannina, Greece.
    Uitterlinden, Andre G.
    Univ Med Ctr Rotterdam, Erasmus MC, Dept Internal Med, Rotterdam, Netherlands.
    Vaccargiu, Simona
    UOS Sassari, Natl Res Council Italy, Inst Genet & Biomed Res, Sassari, Italy.
    Van Dam, Rob M.
    Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore;Natl Univ Hlth Syst, Singapore, Singapore;Natl Univ Hlth Syst, Singapore, Singapore;Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore, Singapore.
    Van der Harst, Pim
    Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands;Univ Groningen, Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands;Netherlands Heart Inst, Durrer Ctr Cardiovasc Res, Utrecht, Netherlands.
    Van Duijn, Cornelia M.
    Univ Med Ctr Rotterdam, Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.
    Edward, Digna R. Velez
    Vanderbilt Univ, Tennessee Valley Healthcare Syst 626, Dept Vet Affairs, 221 Kirkland Hall, Nashville, TN 37235 USA;Vanderbilt Univ, Med Ctr, Dept Obstet & Gynecol, Inst Med & Publ Hlth, Nashville, TN 37232 USA.
    Verweij, Niek
    Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands.
    Vogelezang, Suzanne
    Univ Med Ctr Rotterdam, Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands;Univ Med Ctr Rotterdam, Erasmus MC, Generat R Study Grp, Rotterdam, Netherlands;Univ Med Ctr Rotterdam, Erasmus MC, Dept Pediat, Rotterdam, Netherlands.
    Volker, Uwe
    DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, Greifswald, Germany;Univ Med Greifswald, Interfac Inst Genet & Funct Genom, Greifswald, Germany.
    Vollenweider, Peter
    Lausanne Univ Hosp, Dept Med, Internal Med, Lausanne, Switzerland.
    Waeber, Gerard
    Lausanne Univ Hosp, Dept Med, Internal Med, Lausanne, Switzerland.
    Waldenberger, Melanie
    German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, Neuherberg, Germany;German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol, Neuherberg, Germany;DZHK German Ctr Cardiovasc Res, Partner Site Munich Heart Alliance, Munich, Germany.
    Wallentin, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
    Wang, Ya Xing
    Capital Med Univ, Beijing Tongren Hosp, Beijing Key Lab Ophthalmol & Visual Sci, Beijing Inst Ophthalmol, Beijing, Peoples R China.
    Wang, Chaolong
    Agcy Sci Technol & Res, Genome Inst Singapore, Singapore, Singapore;Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Wuhan, Hubei, Peoples R China.
    Waterworth, Dawn M.
    GlaxoSmithKline, Target Sci Genet, Collegeville, PA USA.
    Bin Wei, Wen
    Capital Med Univ, Beijing Tongren Hosp, Beijing Tongren Eye Ctr, Beijing, Peoples R China.
    White, Harvey
    Auckland City Hosp, Green Lane Cardiovasc Serv, Auckland, New Zealand;Univ Auckland, Auckland, New Zealand.
    Whitfield, John B.
    QIMR Berghofer Med Res Inst, Brisbane, Qld, Australia.
    Wild, Sarah H.
    Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Ctr Populat Hlth Sci, Edinburgh, Midlothian, Scotland.
    Wilson, James F.
    Univ Edinburgh, Inst Genet & Mol Med, Med Res Council, Human Genet Unit, Edinburgh, Midlothian, Scotland;Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Ctr Global Hlth Res, Edinburgh, Midlothian, Scotland.
    Wojczynski, Mary K.
    Washington Univ, Sch Med, Dept Genet, Div Stat Genom, St Louis, MO 63110 USA.
    Wong, Charlene
    Natl Univ Hlth Syst, Singapore, Singapore;Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Ophthalmol, Singapore, Singapore.
    Wong, Tien-Yin
    Natl Univ Hlth Syst, Singapore, Singapore;Singapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore, Singapore;Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Ophthalmol, Singapore, Singapore.
    Xu, Liang
    Capital Med Univ, Beijing Tongren Hosp, Beijing Key Lab Ophthalmol & Visual Sci, Beijing Inst Ophthalmol, Beijing, Peoples R China.
    Yang, Qiong
    Boston Univ, Sch Med, Dept Biostat, Boston, MA 02118 USA.
    Yasuda, Masayuki
    Singapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore, Singapore;Tohoku Univ, Grad Sch Med, Dept Ophthalmol, Sendai, Miyagi, Japan.
    Yerges-Armstrong, Laura M.
    GlaxoSmithKline, Target Sci Genet, Collegeville, PA USA.
    Zhang, Weihua
    Ealing Gen Hosp, Dept Cardiol, Middlesex, England;Imperial Coll London, Sch Publ Hlth, MRC PHE Ctr Environm & Hlth, Dept Epidemiol & Biostat, London, England.
    Zonderman, Alan B.
    NIA, Lab Epidemiol & Populat Sci, Intramural Res Program, US NIH, Baltimore, MD 21224 USA.
    Rotter, Jerome I.
    Harbor UCLA Med Ctr, Los Angeles Biomed Res Inst, Dept Pediat, Inst Translat Genom & Populat Sci, Torrance, CA 90509 USA;Harbor UCLA Med Ctr, Dept Pediat, Torrance, CA 90509 USA;Harbor UCLA Med Ctr, Dept Med, Torrance, CA 90509 USA.
    Bochud, Murielle
    Lausanne Univ Hosp, Inst Social & Prevent Med, Lausanne, Switzerland.
    Psaty, Bruce M.
    Univ Washington, Dept Hlth Serv, Dept Epidemiol, Cardiovasc Hlth Res Unit,Dept Med, Seattle, WA 98195 USA;Kaiser Permanente Washington Hlth Res Inst, Seattle, WA USA.
    Vitart, Veronique
    Univ Edinburgh, Inst Genet & Mol Med, Med Res Council, Human Genet Unit, Edinburgh, Midlothian, Scotland.
    Wilson, James G.
    Univ Mississippi, Med Ctr, Dept Physiol & Biophys, Jackson, MS 39216 USA.
    Dehghan, Abbas
    Imperial Coll London, Sch Publ Hlth, Fac Med, Dept Epidemiol & Biostat, London, England;Imperial Coll London, Sch Publ Hlth, MRC PHE Ctr Environm & Hlth, Dept Epidemiol & Biostat, London, England.
    Parsa, Afshin
    NIDDK, Div Kidney Urol & Hematol Dis, NIH, Bethesda, MD 20892 USA;Univ Maryland, Sch Med, Dept Med, Baltimore, MD 21201 USA.
    Chasman, Daniel I.
    Brigham & Womens Hosp, Div Prevent Med, 75 Francis St, Boston, MA 02115 USA;Harvard Med Sch, Boston, MA 02115 USA.
    Ho, Kevin
    Geisinger, KHRI, Danville, PA USA;Geisinger, Dept Nephrol, Danville, PA USA.
    Morris, Andrew P.
    Univ Liverpool, Dept Biostat, Liverpool, Merseyside, England;Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.
    Devuyst, Olivier
    Univ Zurich, Inst Physiol, Zurich, Switzerland.
    Akilesh, Shreeram
    Univ Washington, Kidney Res Inst, Seattle, WA 98195 USA;Univ Washington, Med Ctr, Anat Pathol, Seattle, WA 98195 USA.
    Pendergrass, Sarah A.
    Geisinger Res, Biomed & Translat Informat Inst, Danville, PA USA.
    Sim, Xueling
    Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore;Natl Univ Hlth Syst, Singapore, Singapore.
    Boger, Carsten A.
    Univ Hosp Regensburg, Dept Nephrol, Regensburg, Germany;Kliniken Sudostbayern, Dept Nephrol & Rheumatol, Regensburg, Germany.
    Okada, Yukinori
    RIKEN, Ctr Integrat Med Sci IMS, Lab Stat Anal, Osaka, Japan;Osaka Univ, Grad Sch Med, Dept Stat Genet, Osaka, Japan.
    Edwards, Todd L.
    Vanderbilt Univ, Tennessee Valley Healthcare Syst 626, Dept Vet Affairs, 221 Kirkland Hall, Nashville, TN 37235 USA;Vanderbilt Univ, Med Ctr, Dept Med, Vanderbilt Genet Inst,Div Epidemiol, Nashville, TN USA.
    Snieder, Harold
    Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands.
    Stefansson, Kari
    Amgen Inc, deCODE Genet, Reykjavik, Iceland.
    Hung, Adriana M.
    Vanderbilt Univ, Tennessee Valley Healthcare Syst 626, Dept Vet Affairs, 221 Kirkland Hall, Nashville, TN 37235 USA;Vanderbilt Univ, Med Ctr, Div Nephrol & Hypertens, Nashville, TN USA.
    Heid, Iris M.
    Univ Regensburg, Dept Genet Epidemiol, Regensburg, Germany.
    Scholz, Markus
    Univ Leipzig, Inst Med Informat Stat & Epidemiol, Leipzig, Germany;Univ Leipzig, LIFE Res Ctr Civilizat Dis, Leipzig, Germany.
    Teumer, Alexander
    Univ Med Greifswald, Inst Community Med, Greifswald, Germany;DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, Greifswald, Germany.
    Kottgen, Anna
    Univ Freiburg, Fac Med, Dept Biometry Epidemiol & Med Bioinformat, Inst Genet Epidemiol, Freiburg, Germany;Univ Freiburg, Med Ctr, Freiburg, Germany;Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA.
    Pattaro, Cristian
    Univ Lubeck, Inst Biomed, Eurac Res, Bolzano, Italy.
    A catalog of genetic loci associated with kidney function from analyses of a million individuals2019In: Nature Genetics, ISSN 1061-4036, E-ISSN 1546-1718, Vol. 51, no 6, p. 957-972Article in journal (Refereed)
    Abstract [en]

    Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through transancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these,147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.

  • 962.
    Xavier, D.
    et al.
    St Johns Med Coll Hosp, Bangalore, Karnataka, India..
    Hanna, M.
    Bristol Myers Squibb, Princeton, NJ USA..
    Wallentin, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    Alexander, J.
    Duke Clin Res Inst, Cardiol, Durham, NC USA..
    Lopes, R.
    Duke Clin Res Inst, Cardiol, Durham, NC USA..
    Merrill, P.
    Duke Clin Res Inst, Cardiol, Durham, NC USA..
    Wojdyla, D.
    Duke Clin Res Inst, Cardiol, Durham, NC USA..
    Bahit, C.
    INECO Neurociencias Orono, Rosario, Argentina..
    Hohnloser, S.
    Goethe Univ Frankfurt, Frankfurt, Germany..
    Granger, C.
    Duke Clin Res Inst, Cardiol, Durham, NC USA..
    Patients with atrial fibrillation treated with apixaban are less likely to discontinue study drug when compared with warfarin: insights from the ARISTOTLE trial2016Conference paper (Refereed)
  • 963.
    Xu, Shengyuan
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
    Lind, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Internal Medicine.
    Zhao, Linshu
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medical Genetics.
    Lindahl, Bertil
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    Venge, Per
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
    Plasma Prolylcarboxypeptidase (Angiotensinase C) Is Increased in Obesity and Diabetes Mellitus and Related to Cardiovascular Dysfunction2012In: Clinical Chemistry, ISSN 0009-9147, E-ISSN 1530-8561, Vol. 58, no 7, p. 1110-1115Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Prolylcarboxypeptidase (PRCP) (angiotensinase C) has 3 major targets, angiotensin II, prekallikrein, and alpha-melanocyte stimulating hormone(1-13). The truncation of the latter leads to loss in appetite regulation and obesity in experimental animals. The objectives of this study were to purify PRCP from a native source, establish a sensitive immunoassay for PRCP, and relate plasma PRCP concentrations to signs and symptoms of obesity, diabetes mellitus, and cardiovascular dysfunction.

    METHODS: Purification of PRCP from human neutrophils and establishment of a sensitive ELISA was carried out with the use of samples from study participants. Three cohorts were studied: healthy individuals (n = 40); a chest pain cohort (Fast Assessment of Thoracic Pain by Neural Networks) (n = 165); and a community-based cohort [Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS)] (n = 1004).

    RESULTS: PRCP was purified to homogeneity. Mean (SD) plasma concentrations in healthy individuals were 12.9 (3.2), mu g/L and were increased in patients with chest pain and in patients with obesity and/or diabetes mellitus (P < 0.0001). In the PIVUS cohort the concentrations were related to several measures of arterial plaque formation, thickness of arterial intima media and posterior wall of the heart (P = 0.04-0.000005); the Framingham score (r = 0.14, P < 0.0001); and concentrations of C-reactive protein (r = 0.16, P < 0.0001) and N-terminal pro B-type natriuretic peptide (r = -0.13, P < 0.0001).

    CONCLUSIONS: Plasma concentrations of PRCP may be used to reflect metabolic conditions in individuals with obesity and diabetes mellitus. The associations of PRCP concentrations with signs of cardiovascular dysfunction and cardiovascular abnormalities suggest a pivotal role of the enzyme in disease. (c) 2012 American Association for Clinical Chemistry

  • 964. Yang, Dong
    et al.
    James, Stefan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    De Faire, Ulf
    Alfredsson, Lars
    Jernberg, Tomas
    Moradi, Tahereh
    Differences in undergoing cardiac procedures within three months after first myocardial infarction by country of birth in women and men: a Swedish national cohort study2015In: Acute Cardiac Care, ISSN 1748-2941, E-ISSN 1748-295X, Vol. 17, no 1, p. 5-13Article in journal (Refereed)
    Abstract [en]

    OBJECTIVE

    To examine the relationship between country of birth and the utilization of coronary angiography, percutaneous coronary intervention (PCI) and coronary artery bypass graft (CABG) after a first-time myocardial infarction (MI).

    DESIGN, SETTING AND PATIENTS

    117,494 MI patients of all ages who were admitted to coronary care units between 2001 and 2009 in Sweden were followed-up for three months after admission.

    MAIN OUTCOME MEASURES

    Undergoing coronary angiography, PCI or CABG after first-time MI.

    RESULTS

    proportion of patients undergoing angiography and PCI increased whereas proportion of patients undergoing CABG also delay time for all three procedures decreased over the study period. The proportion of women undergoing any of the three procedures was markedly lower and delay time longer than those of men regardless of study period and migration background. Overall foreign-born first MI patients had higher rate of angiography (HR = 1.30, 95% CI: 1.27-1.33), PCI (HR = 1.27, 95% CI: 1.24-1.30) and CABG (HR = 1.21, 95% CI: 1.15-1.28) compared with Sweden born first MI patients. After controlling for potential confounding factors in multivariable models, the overall differences vanished for angiography and reduced markedly for PCI and CABG. However, multivariable stratified analysis by specific country of birth yielded higher rate of angiography among men born in Uganda (HR = 2.11, 95% CI: 1.00-4.43) and Peru (HR = 1.98, 95% CI: 1.07-3.68) and lower rate among men born in Croatia (HR = 0.71, 95% CI: 0.52-0.99) and women born in Thailand (HR = 0.49, 95% CI: 0.35-0.94). PCI adjusted rates were higher among women born in Palestine state (HR = 2.44, 95% CI: 1.15-5.16), Iraq (HR = 1.34, 95% CI: 1.04-1.74) and Poland (HR = 1.21, 95% CI: 1.02-1.44) and rate of CABG was higher among immigrants from some parts of Asia, including men born in Sri Lanka (HR = 3.19, 95% CI: 1.43-7.12), India (HR = 1.95, 95% CI: 1.21-3.14), Vietnam (HR = 2.65, 95% CI: 1.32-5.33), Palestine State (HR = 2.11, 95% CI: 1.06-4.24), and women born in Syria (HR = 2.36, 95% CI: 1.25-4.45), Iraq (HR = 1.74, 95% CI: 1.02-2.94), and Turkey (HR = 1.70, 95% CI: 1.03-2.79).

    CONCLUSIONS

    The observed high rate of CABG for immigrants and particularly those born in some Asian countries was not explained by the potential confounding factors. A more severe coronary disease in this population might explain this high rate but needs further research. Awareness and subsequent intervention at earlier stage of coronary disease among immigrants could prolong their life and reduce the healthcare costs.

  • 965. Yang, Dong
    et al.
    James, Stefan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    de Faire, Ulf
    Alfredsson, Lars
    Jernberg, Tomas
    Moradi, Tahereh
    Likelihood of Treatment in a Coronary Care Unit for a First-Time Myocardial Infarction in Relation to Sex, Country of Birth and Socioeconomic Position in Sweden2013In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 8, no 4, p. e62316-Article in journal (Refereed)
    Abstract [en]

    Objective: To examine the relationship between sex, country of birth, level of education as an indicator of socioeconomic position, and the likelihood of treatment in a coronary care unit (CCU) for a first-time myocardial infarction. Design: Nationwide register based study. Setting: Sweden. Patients: 199 906 patients (114 387 men and 85,519 women) of all ages who were admitted to hospital for first-time myocardial infarction between 2001 and 2009. Main outcome measures: Admission to a coronary care unit due to myocardial infarction. Results: Despite the observed increasing access to coronary care units over time, the proportion of women treated in a coronary care unit was 13% less than for men. As compared with men, the multivariable adjusted odds ratio among women was 0.80 (95% confidence interval 0.77 to 0.82). This lower proportion of women treated in a CCU varied by age and year of diagnosis and country of birth. Overall, there was no evidence of a difference in likelihood of treatment in a coronary care unit between Sweden-born and foreign-born patients. As compared with patients with high education, the adjusted odds ratio among patients with a low level of education was 0.93 (95% confidence interval 0.89 to 0.96). Conclusions: Foreign-born and Sweden-born first-time myocardial infarction patients had equal opportunity of being treated in a coronary care unit in Sweden; this is in contrast to the situation in many other countries with large immigrant populations. However, the apparent lower rate of coronary care unit admission after first-time myocardial infarction among women and patients with low socioeconomic position warrants further investigation.

  • 966.
    Yeo, Astrid
    et al.
    GlaxoSmithKline Med Res Ctr, Dept Genet, Stevenage, Herts, England..
    Li, Li
    GlaxoSmithKline Med Res Ctr, Dept Genet, Res Triangle Pk, NC USA.;PAREXEL Int, Genom Med, Durham, NC USA..
    Warren, Liling
    GlaxoSmithKline Med Res Ctr, Dept Genet, Res Triangle Pk, NC USA.;Teva Pharmaceut, Raleigh, NC USA..
    Aponte, Jennifer
    GlaxoSmithKline Med Res Ctr, Dept Genet, Res Triangle Pk, NC USA.;PAREXEL Int, Genom Med, Durham, NC USA..
    Fraser, Dana
    GlaxoSmithKline Med Res Ctr, Dept Genet, Res Triangle Pk, NC USA.;PAREXEL Int, Genom Med, Durham, NC USA..
    King, Karen
    GlaxoSmithKline Med Res Ctr, Dept Genet, Res Triangle Pk, NC USA.;PAREXEL Int, Genom Med, Durham, NC USA..
    Johansson, Kelley
    GlaxoSmithKline Med Res Ctr, Dept Genet, Res Triangle Pk, NC USA.;PAREXEL Int, Genom Med, Durham, NC USA..
    Barnes, Allison
    GlaxoSmithKline Med Res Ctr, Clin Stat, Res Triangle Pk, NC USA.;PAREXEL Int, Biostat, Durham, NC USA..
    MacPhee, Colin
    GlaxoSmithKline Med Res Ctr, Dept Vasc Biol & Thrombosis, King Of Prussia, PA USA..
    Davies, Richard
    GlaxoSmithKline Med Res Ctr, Metab Pathways & Cardiovasc Therapeut Area, King Of Prussia, PA USA..
    Chissoe, Stephanie
    GlaxoSmithKline Med Res Ctr, Dept Genet, Res Triangle Pk, NC USA.;GlaxoSmithKline, Elliott Ave, Seattle, WA USA..
    Tarka, Elizabeth
    GlaxoSmithKline Med Res Ctr, Metab Pathways & Cardiovasc Therapeut Area, King Of Prussia, PA USA.;Janssen Pharmaceut, Spring House, PA USA..
    O'Donoghue, Michelle L.
    Brigham & Womens Hosp, Div Cardiovasc, TIMI Study Grp, 75 Francis St, Boston, MA 02115 USA..
    White, Harvey D.
    Auckland City Hosp, Green Lane Cardiovasc Serv, Auckland, New Zealand.;Univ Auckland, Auckland, New Zealand..
    Wallentin, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
    Waterworth, Dawn
    GlaxoSmithKline Med Res Ctr, Dept Genet, Philadelphia, PA USA..
    Pharmacogenetic meta-analysis of baseline risk factors, pharmacodynamic, efficacy and tolerability endpoints from two large global cardiovascular outcomes trials for darapladib2017In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 12, no 7, article id e0182115Article in journal (Refereed)
    Abstract [en]

    Darapladib, a lipoprotein-associated phospholipase A2 (Lp-PLA(2)) inhibitor, failed to demonstrate efficacy for the primary endpoints in two large phase III cardiovascular outcomes trials, one in stable coronary heart disease patients (STABILITY) and one in acute coronary syndrome (SOLID-TIMI 52). No major safety signals were observed but tolerability issues of diarrhea and odor were common (up to 13%). We hypothesized that genetic variants associated with Lp-PLA(2) activity may influence efficacy and tolerability and therefore performed a comprehensive pharmacogenetic analysis of both trials. We genotyped patients within the STABILITY and SOLID-TIMI 52 trials who provided a DNA sample and consent (n = 13,577 and 10,404 respectively, representing 86% and 82% of the trial participants) using genomewide arrays with exome content and performed imputation using a 1000 Genomes reference panel. We investigated baseline and change from baseline in Lp-PLA(2) activity, two efficacy endpoints (major coronary events and myocardial infarction) as well as tolerability parameters at genome-wide and candidate gene level using a meta-analytic approach. We replicated associations of published loci on baseline Lp-PLA2 activity (APOE, CELSR2, LPA, PLA2G7, LDLR and SCARB1) and identified three novel loci (TOMM5, FRMD5 and LPL) using the GWAS-significance threshold P <= 5E-08. Review of the PLA2G7 gene (encoding Lp-PLA(2)) within these datasets identified V279F null allele carriers as well as three other rare exonic null alleles within various ethnic groups, however none of these variants nor any other loci associated with Lp-PLA(2) activity at baseline were associated with any of the drug response endpoints. The analysis of darapladib efficacy endpoints, despite low power, identified six low frequency loci with main genotype effect (though with borderline imputation scores) and one common locus (minor allele frequency 0.24) with genotype by treatment interaction effect passing the GWAS-significance threshold. This locus conferred risk in placebo subjects, hazard ratio (HR) 1.22 with 95% confidence interval (CI) 1.11-1.33, but was protective in darapladib subjects, HR 0.79 ( 95% CI 0.71-0.88). No major loci for tolerability were found. Thus, genetic analysis confirmed and extended the influence of lipoprotein loci on Lp-PLA(2) levels, identified some novel null alleles in the PLA2G7 gene, and only identified one potentially efficacious subgroup within these two large clinical trials.

  • 967. Yilmaz, Mehmet B.
    et al.
    Grossini, Elena
    Silva Cardoso, Jose C.
    Edes, Istvan
    Fedele, Francesco
    Pollesello, Piero
    Kivikko, Matti
    Harjola, Veli-Pekka
    Hasslacher, Julia
    Mebazaa, Alexandre
    Morelli, Andrea
    le Noble, Jos
    Oldner, Anders
    Oulego Erroz, Ignacio
    Parissis, John T.
    Parkhomenko, Alexander
    Poelzl, Gerhard
    Rehberg, Sebastian
    Ricksten, Sven-Erik
    Rodriguez Fernandez, Luis M.
    Salmenpera, Markku
    Singer, Mervyn
    Treskatsch, Sascha
    Vrtovec, Bojan
    Wikström, Gerhard
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    Renal Effects of Levosimendan: A Consensus Report2013In: Cardiovascular Drugs and Therapy, ISSN 0920-3206, E-ISSN 1573-7241, Vol. 27, no 6, p. 581-590Article, review/survey (Refereed)
    Abstract [en]

    Renal dysfunction is common in clinical settings in which cardiac function is compromised such as heart failure, cardiac surgery or sepsis, and is associated with high morbidity and mortality. Levosimendan is a calcium sensitizer and potassium channel opener used in the treatment of acute heart failure. This review describes the effects of the inodilator levosimendan on renal function. A panel of 25 scientists and clinicians from 15 European countries (Austria, Finland, France, Hungary, Germany, Greece, Italy, Portugal, the Netherlands, Slovenia, Spain, Sweden, Turkey, the United Kingdom, and Ukraine) convened and reached a consensus on the current interpretation of the renal effects of levosimendan described both in non-clinical research and in clinical study reports. Most reports on the effect of levosimendan indicate an improvement of renal function in heart failure, sepsis and cardiac surgery settings. However, caution should be applied as study designs differed from randomized, controlled studies to uncontrolled ones. Importantly, in the largest HF study (REVIVE I and II) no significant changes in the renal function were detected. As it regards the mechanism of action, the opening of mitochondrial K-ATP channels by levosimendan is involved through a preconditioning effect. There is a strong rationale for randomized controlled trials seeking beneficial renal effects of levosimendan. As an example, a study is shortly to commence to assess the role of levosimendan for the prevention of acute organ dysfunction in sepsis (LeoPARDS).

  • 968.
    Yi-Ting, Lin
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    Fall, Tove
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology.
    Gustafsson, Stefan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology.
    Ingelsson, Erik
    Stanford Univ, Sch Med, Dept Med, Div Cardiovasc Med, Stanford, CA 94305 USA.
    Arnlov, Johan
    Karolinska Inst, Dept Neurobiol, Div Family Med & Primary Care, Stockholm, Sweden.
    Lind, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Epidemiology.
    Engström, Gunnar
    Lund Univ, Dept Clin Sci, Cardiovasc Epidemiol, Lund, Sweden.
    Sundström, Johan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    Use of Proteomics to Investigate Blood Pressure Progress in the Elderly2018In: Journal of Hypertension, ISSN 0263-6352, E-ISSN 1473-5598, Vol. 36, p. E115-E115Article in journal (Other academic)
  • 969.
    Yusuf, Salim
    et al.
    McMaster Univ, Hamilton Hlth Sci, Populat Hlth Res Inst, Hamilton, ON, Canada.;McMaster Univ, Dept Med, Hamilton, ON, Canada..
    Lonn, Eva
    McMaster Univ, Hamilton Hlth Sci, Populat Hlth Res Inst, Hamilton, ON, Canada.;McMaster Univ, Dept Med, Hamilton, ON, Canada..
    Pais, Prem
    St Johns Res Inst, Bangalore, Karnataka, India..
    Bosch, Jackie
    McMaster Univ, Hamilton Hlth Sci, Populat Hlth Res Inst, Hamilton, ON, Canada.;McMaster Univ, Sch Rehabil Sci, Hamilton, ON, Canada..
    Lopez-Jaramillo, Patricio
    Univ Santander, Fdn Oftalmol Santander, Bucaramanga, Colombia.;Univ Santander, Inst Masira, Sch Med, Bucaramanga, Colombia..
    Zhu, Jun
    Chinese Acad Med Sci, Fu Wai Hosp, Beijing 100730, Peoples R China.;Peking Union Med Coll, Beijing 100021, Peoples R China..
    Xavier, Denis
    St Johns Res Inst, Bangalore, Karnataka, India.;St Johns Med Coll, Bangalore, Karnataka, India..
    Avezum, Alvaro
    Dante Pazzanese Inst Cardiol, Sao Paulo, Brazil..
    Leiter, Lawrence A.
    Univ Toronto, St Michaels Hosp, Li Ka Shing Knowledge Inst, Toronto, ON, Canada.;Univ Toronto, St Michaels Hosp, Keenan Res Ctr Biomed Sci, Toronto, ON, Canada..
    Piegas, Leopoldo S.
    HCor Heart Hosp, Sao Paulo, Brazil..
    Parkhomenko, Alexander
    Inst Cardiol, Kiev, Ukraine..
    Keltai, Matyas
    Semmelweis Univ, Hungarian Inst Cardiol, H-1085 Budapest, Hungary..
    Keltai, Katalin
    Semmelweis Univ, Hungarian Inst Cardiol, H-1085 Budapest, Hungary..
    Sliwa, Karen
    Univ Cape Town, Hatter Inst Cardiovasc Res Africa, Dept Med, Soweto Cardiovasc Res Grp, ZA-7925 Cape Town, South Africa..
    Chazova, Irina
    Inst Clin Cardiol, Russian Cardiol Res Complex, Moscow, Russia..
    Peters, Ron J. G.
    Univ Amsterdam, Acad Med Ctr, Dept Cardiol, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands..
    Held, Claes
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
    Yusoff, Khalid
    Univ Teknologi Majlis Amansh Rakyat, Selayang, Malaysia.;Univ Coll Sedaya Int Univ, Kuala Lumpur, Malaysia..
    Lewis, Basil S.
    Technion Israel Inst Technol, Ruth & Bruce Rappaport Sch Med, Lady Davis Carmel Med Ctr, Haifa, Israel..
    Jansky, Petr
    Univ Hosp Motol, Prague, Czech Republic..
    Khunti, Kamlesh
    Univ Leicester, Diabet Res Ctr, Leicester, Leics, England..
    Toff, William D.
    Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England.;Glenfield Hosp, Natl Inst Hlth Res, Leicester Cardiovasc Biomed Res Unit, Leicester, Leics, England..
    Reid, Christopher M.
    Monash Ctr Cardiovasc Res & Educ Therapeut, Primary Care Diabet & Vasc Med, Melbourne, Vic, Australia.;Curtin Univ, Sch Publ Hlth, Perth, WA 6845, Australia..
    Varigos, John
    Monash Univ, Dept Epidemiol & Prevent Med, Melbourne, Vic 3004, Australia..
    Accini, Jose L.
    Univ Norte, Barranquilla, Colombia..
    McKelvie, Robert
    McMaster Univ, Hamilton Hlth Sci, Populat Hlth Res Inst, Hamilton, ON, Canada.;McMaster Univ, Dept Med, Hamilton, ON, Canada..
    Pogue, Janice
    McMaster Univ, Hamilton Hlth Sci, Populat Hlth Res Inst, Hamilton, ON, Canada.;McMaster Univ, Dept Clin Epidemiol & Biostat, Hamilton, ON, Canada..
    Jung, Hyejung
    McMaster Univ, Hamilton Hlth Sci, Populat Hlth Res Inst, Hamilton, ON, Canada..
    Liu, Lisheng
    Chinese Acad Med Sci, Fu Wai Hosp, Beijing 100730, Peoples R China.;Peking Union Med Coll, Beijing 100021, Peoples R China..
    Diaz, Rafael
    Inst Cardiovasc Rosario, Rosario, Santa Fe, Argentina..
    Dans, Antonio
    Univ Philippines, Coll Med, Manila, Philippines..
    Dagenais, Gilles
    Univ Laval, Inst Univ Cardiol & Pneumol Quebec, Quebec City, PQ, Canada..
    Blood-Pressure and Cholesterol Lowering in Persons without Cardiovascular Disease2016In: New England Journal of Medicine, ISSN 0028-4793, E-ISSN 1533-4406, Vol. 374, no 21, p. 2032-2043Article in journal (Refereed)
    Abstract [en]

    BACKGROUND Elevated blood pressure and elevated low-density lipoprotein (LDL) cholesterol increase the risk of cardiovascular disease. Lowering both should reduce the risk of cardiovascular events substantially.

    METHODS In a trial with 2-by-2 factorial design, we randomly assigned 12,705 participants at intermediate risk who did not have cardiovascular disease to rosuvastatin (10 mg per day) or placebo and to candesartan (16 mg per day) plus hydrochlorothiazide (12.5 mg per day) or placebo. In the analyses reported here, we compared the 3180 participants assigned to combined therapy (with rosuvastatin and the two antihypertensive agents) with the 3168 participants assigned to dual placebo. The first coprimary outcome was the composite of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke, and the second coprimary outcome additionally included heart failure, cardiac arrest, or revascularization. The median follow-up was 5.6 years.

    RESULTS The decrease in the LDL cholesterol level was 33.7 mg per deciliter (0.87 mmol per liter) greater in the combined-therapy group than in the dual-placebo group, and the decrease in systolic blood pressure was 6.2 mm Hg greater with combined therapy than with dual placebo. The first coprimary outcome occurred in 113 participants (3.6%) in the combined-therapy group and in 157 (5.0%) in the dual-placebo group (hazard ratio, 0.71; 95% confidence interval [CI], 0.56 to 0.90; P=0.005). The second coprimary outcome occurred in 136 participants (4.3%) and 187 participants (5.9%), respectively (hazard ratio, 0.72; 95% CI, 0.57 to 0.89; P=0.003). Muscle weakness and dizziness were more common in the combined-therapy group than in the dual-placebo group, but the overall rate of discontinuation of the trial regimen was similar in the two groups.

    CONCLUSIONS The combination of rosuvastatin (10 mg per day), candesartan (16 mg per day), and hydrochlorothiazide (12.5 mg per day) was associated with a significantly lower rate of cardiovascular events than dual placebo among persons at intermediate risk who did not have cardiovascular disease. (ClinicalTrials.gov number, NCT00468923.)

  • 970.
    Zewinger, Stephen
    et al.
    Saarland Univ Hosp, Dept Internal Med 4, Homburg, Germany..
    Kleber, Marcus E.
    Friedrich Schiller Univ, Inst Nutr, Jena, Germany..
    Tragante, Vinicius
    McCubrey, Raymond O.
    Univ Utah Sch Med, Intermountain Heart Inst, Intermountain Med Ctr, Salt Lake City, UT USA..
    Schmidt, Amand F.
    Direk, Kenan
    Laufs, Ulrich
    Saarland Univ Hosp, Dept Internal Med 3, Homburg, Germany..
    Werner, Christian
    Saarland Univ Hosp, Dept Internal Med 3, Homburg, Germany..
    Koenig, Wolfgang
    Univ Ulm Med Ctr, Dept Internal Med Cardiol 2, Ulm, Germany.;Tech Univ Munich, Deutsch Herzzentrum M nchen, Munich, Germany.;Partner site Munich Heart Alliance, German Ctr Cardiovasc Res DZHK, Munich, Germany..
    Rothenbacher, Dietrich
    German Canc Ctr DKFZ, Div Clin Epidemiol & Ageing Res, Heidelberg, Germany.;Univ Ulm, Inst Epidemiol & Med Biometry, Ulm, Germany.;German Ctr Cardiovasc Res DZHK eV, Kiel, Germany..
    Mons, Ute
    German Canc Ctr DKFZ, Div Clin Epidemiol & Ageing Res, Heidelberg, Germany..
    Breitling, Lutz P.
    German Canc Ctr DKFZ, Div Clin Epidemiol & Ageing Res, Heidelberg, Germany.;Univ Heart Ctr Hamburg, Clin Gen & Intervent Cardiol, Hamburg, Germany..
    Brenner, Herrmann
    Heidelberg Univ, Dept Med, Network Ageing Res, Mannheim, Germany.;German Canc Ctr DKFZ, Div Clin Epidemiol & Ageing Res, Heidelberg, Germany..
    Jennings, Richard T.
    Saarland Univ Hosp, Dept Internal Med 4, Homburg, Germany.;Univ Heart Ctr Hamburg, Clin Gen & Intervent Cardiol, Hamburg, Germany..
    Petrakis, Ioannis
    Saarland Univ Hosp, Dept Internal Med 4, Homburg, Germany..
    Triem, Sarah
    Saarland Univ Hosp, Dept Internal Med 4, Homburg, Germany..
    Klug, Mira
    Saarland Univ Hosp, Dept Internal Med 4, Homburg, Germany..
    Filips, Alexandra
    Saarland Univ Hosp, Dept Internal Med 4, Homburg, Germany.;UCL, Inst Cardiovasc Sci Facultyof Populat Hlth Sc, London, England..
    Blankenberg, Stefan
    Waldeyer, Christoph
    Sinning, Christoph
    Schnabel, Renate B.
    Lackner, Karl J.
    Univ Med Ctr Mainz, Inst Clin Chem & Lab Med, Mainz, Germany..
    Vlachopoulou, Efthymia
    Univ Helsinki, Haartman Inst, Transplantat Lab, Helsinki, Finland..
    Nygard, Ottar
    Univ Bergen, Dept Clin Sci, Bergen, Norway.;Haukeland Hosp, Dept Heart Dis, Bergen, Norway..
    Svingen, Gard Frodahl Tveitevag
    Univ Bergen, Dept Clin Sci, Bergen, Norway.;Haukeland Hosp, Dept Heart Dis, Bergen, Norway..
    Pedersen, Eva Ringdal
    Univ Bergen, Dept Clin Sci, Bergen, Norway.;Haukeland Hosp, Dept Heart Dis, Bergen, Norway..
    Tell, Grethe S.
    Univ Bergen, Dept Global Publ Hlth & Primary Care, Bergen, Norway.;Helsinki Univ Hosp, Heart & Lung Ctr, Helsinki, Finland..
    Sinisalo, Juha
    Med Univ Graz, Clin Inst Med & Chem Lab Diagnost, Graz, Austria..
    Nieminen, Markku S.
    Natl Univ Singapore, Cardiovasc Res Inst, Singapore, Singapore..
    Laaksonen, Reijo
    Tampere Univ, Sch Med, Tampere, Finland.;Tampere Univ Hosp, Finnish Clin Biobank Tampere, Tampere, Finland..
    Trompet, Stella
    German Ctr Cardiovasc Res DZHK eV, Kiel, Germany.;Leiden Univ Med Ctr, Dept Geriat & Gerontol, Leiden, Netherlands.;Leiden Univ Med Ctr, Dept Cardiol, Leiden, Netherlands.;Leiden Univ Med Ctr, Einthoven Lab Expt Vasc Med, Leiden, Netherlands..
    Smit, Roelof A. J.
    Univ Utah Sch Med, Intermountain Heart Inst, Intermountain Med Ctr, Salt Lake City, UT USA.;Leiden Univ Med Ctr, Dept Geriat & Gerontol, Leiden, Netherlands.;Leiden Univ Med Ctr, Dept Cardiol, Leiden, Netherlands..
    Sattar, Naveed
    Heidelberg Univ, Dept Med, Mannheim, Germany.;Helsinki Univ Hosp, Heart & Lung Ctr, Helsinki, Finland..
    Jukema, J. Wouter
    Helsinki Univ Hosp, Heart & Lung Ctr, Helsinki, Finland.;Leiden Univ Med Ctr, Einthoven Lab Expt Vasc Med, Leiden, Netherlands.;Leiden Univ Med Ctr, Einthoven Lab Expt Vasc Med, Leiden, Netherlands.;Inst Netherlands, Interunivers Cardiol, Utrecht, Netherlands..
    Groesdonk, Heinrich V.
    Saarland Univ Hosp, Dept Anesthesiol Intens Care Med & Pain Med, Homburg, Germany.;German Ctr Cardiovasc Res DZHK eV, Kiel, Germany.;Leiden Univ Med Ctr, Einthoven Lab Expt Vasc Med, Leiden, Netherlands.;Leiden Univ Med Ctr, Einthoven Lab Expt Vasc Med, Leiden, Netherlands.;Univ Otago, Christchurch Heart Inst, Christchurch, New Zealand..
    Delgado, Graciela
    Univ Utah Sch Med, Intermountain Heart Inst, Intermountain Med Ctr, Salt Lake City, UT USA.;Univ Glasgow, Inst Cardiovascular & Med Sci, Cardiovascular Res Ctr, BHF Glasgow, Glasgow, Lanark, Scotland.;Inst Netherlands, Interunivers Cardiol, Utrecht, Netherlands..
    Stojakovic, Tatjana
    Heidelberg Univ, Dept Med, Mannheim, Germany.;Leiden Univ Med Ctr, Einthoven Lab Expt Vasc Med, Leiden, Netherlands.;Univ Glasgow, Inst Cardiovascular & Med Sci, Cardiovascular Res Ctr, BHF Glasgow, Glasgow, Lanark, Scotland..
    Pilbrow, Anna P.
    Leiden Univ Med Ctr, Einthoven Lab Expt Vasc Med, Leiden, Netherlands..
    Cameron, Vicky A.
    Heart & Lungs Div, Dept Cardiol, Utrecht, Netherlands.;Helsinki Univ Hosp, Heart & Lung Ctr, Helsinki, Finland.;Univ Glasgow, Inst Cardiovascular & Med Sci, Cardiovascular Res Ctr, BHF Glasgow, Glasgow, Lanark, Scotland.;Univ Otago, Christchurch Heart Inst, Christchurch, New Zealand..
    Richards, A. Mark
    Univ Otago, Christchurch Heart Inst, Christchurch, New Zealand.;Natl Univ Singapore, Cardiovasc Res Inst, Singapore, Singapore..
    Doughty, Robert N.
    Univ Glasgow, Inst Cardiovascular & Med Sci, Cardiovascular Res Ctr, BHF Glasgow, Glasgow, Lanark, Scotland.;Univ Auckland, Hlth Res Grp, Auckland, New Zealand..
    Gong, Yan
    Heart & Lungs Div, Dept Cardiol, Utrecht, Netherlands.;Univ Utah Sch Med, Intermountain Heart Inst, Intermountain Med Ctr, Salt Lake City, UT USA.;Univ Glasgow, Inst Cardiovascular & Med Sci, Cardiovascular Res Ctr, BHF Glasgow, Glasgow, Lanark, Scotland..
    Cooper-DeHoff, Rhonda
    Johnson, Julie
    German Ctr Cardiovasc Res DZHK eV, Kiel, Germany.;Univ Otago, Christchurch Heart Inst, Christchurch, New Zealand..
    Scholz, Markus
    Univ Utah Sch Med, Intermountain Heart Inst, Intermountain Med Ctr, Salt Lake City, UT USA.;Natl Univ Singapore, Cardiovasc Res Inst, Singapore, Singapore.;Univ Leipzig, D-RES CTR C Leipzig, Germany..
    Beutner, Frank
    Univ Leipzig, Leipzig, Germany..
    Thiery, Joachim
    Univ Hosp, Leipzig, Germany..
    Smith, J. Gustav
    Lund Univ, Dept Cardiol, Clin Sci, Lund, Sweden.;Skane Univ Hoswpital, Lund, Sweden..
    Vilmundarson, Ragnar O.
    Univ Ottawa Heart Inst, Ruddy Canadian Cardiovasc Genet Ctr, Ottawa, ON, Canada..
    McPherson, Ruth
    Univ Ottawa Heart Inst, Ruddy Canadian Cardiovasc Genet Ctr, Ottawa, ON, Canada..
    Stewart, Alexandre F. R.
    Natl Univ Singapore, Cardiovasc Res Inst, Singapore, Singapore.;Univ Florida, Dept Pharmacotherapy, Colleges Pharm, Gainesville, FL USA.;Univ Florida, Dept Pharmacotherapy, Translat Res & Ctr Pharmac, Gainesville, FL USA.;Univ Ottawa Heart Inst, Ruddy Canadian Cardiovasc Genet Ctr, Ottawa, ON, Canada.;Washington Univ, Sch Med, St Louis, MO USA..
    Cresci, Sharon
    Univ Ottawa Heart Inst, Ruddy Canadian Cardiovasc Genet Ctr, Ottawa, ON, Canada.;Washington Univ, Sch Med, Dept Med, St Louis, MO USA.;Washington Univ, Sch Med, Dept Genet, St Louis, MO USA..
    Lenzini, Petra A.
    Inst Med Informat, Stat & Epidemiol, Leipzig, Germany.;Univ Ottawa Heart Inst, Ruddy Canadian Cardiovasc Genet Ctr, Ottawa, ON, Canada.;Washington Univ, Sch Med, Stat Genom Div, Dept Genet, St Louis, MO USA..
    Spertus, John A.
    Inst Med Informat, Stat & Epidemiol, Leipzig, Germany.;St Lukes Mid Amer Heart Inst, Kansas City, MO USA.;Univ Missouri, Dept Biomed Hlth Informat, Kansas City, MO USA..
    Olivieri, Oliviero
    Heart & Lungs Div, Dept Cardiol, Utrecht, Netherlands.;Univ Verona, Dept Med, Verona, Italy..
    Girelli, Domenico
    Univ Florida, Dept Pharmacotherapy, Colleges Pharm, Gainesville, FL USA.;Univ Florida, Dept Pharmacotherapy, Translat Res & Ctr Pharmac, Gainesville, FL USA.;Univ Verona, Dept Med, Verona, Italy..
    Martinelli, Nicola I.
    Univ Verona, Dept Med, Verona, Italy..
    Leiherer, Andreas
    Univ Florida, Dept Pharmacotherapy, Colleges Pharm, Gainesville, FL USA.;Univ Florida, Dept Pharmacotherapy, Translat Res & Ctr Pharmac, Gainesville, FL USA.;Inst Med Informat, Stat & Epidemiol, Leipzig, Germany.;Vorarlberg Inst Vasc Invest & Treatment, Feldkirch, Austria.;Principal Liechtenstein, Private Univ, Triesen, Liechtenstein..
    Saely, Christoph H.
    Vorarlberg Inst Vasc Invest & Treatment, Feldkirch, Austria.;Principal Liechtenstein, Private Univ, Triesen, Liechtenstein..
    Drexel, Heinz
    Heart & Lungs Div, Dept Cardiol, Utrecht, Netherlands.;Univ Florida, Dept Pharmacotherapy, Colleges Pharm, Gainesville, FL USA.;Univ Florida, Dept Pharmacotherapy, Translat Res & Ctr Pharmac, Gainesville, FL USA.;Vorarlberg Inst Vasc Invest & Treatment, Feldkirch, Austria.;Principal Liechtenstein, Private Univ, Triesen, Liechtenstein.;Acad Teaching Hosp Feldkirch, Dept Med & Cardiol, Feldkirch, Austria.;Drexel Univ, Coll Med, Philadelphia, PA USA..
    Muendlein, Axel
    Vorarlberg Inst Vasc Invest & Treatment, Feldkirch, Austria..
    Braund, Peter S.
    Univ Florida, Dept Pharmacotherapy, Colleges Pharm, Gainesville, FL USA.;Univ Florida, Dept Pharmacotherapy, Translat Res & Ctr Pharmac, Gainesville, FL USA.;Univ Leicester, Glenfield Hosp, Dept Cardiovascular Sci, BHF Cardiovascular Res Ctr, Leicester, Leics, England..
    Nelson, Christopher P.
    Univ Leicester, Glenfield Hosp, Dept Cardiovascular Sci, BHF Cardiovascular Res Ctr, Leicester, Leics, England..
    Samani, Nilesh J.
    Heart & Lungs Div, Dept Cardiol, Utrecht, Netherlands.;Leicester NIHR Biomed Res Unit Cardiovasc Dis, Glenfield Hosp, Leicester, Leics, England.;Uppsala Univ, Uppsala Clin Res Ctr, Uppsala, Sweden.;Uppsala Univ, Dept Med Sci, Cardiol, Uppsala, Sweden..
    Kofink, Daniel
    Hoefer, Imo E.
    Pasterkamp, Gerard
    Quyyumi, Arshed A.
    Emory Univ, Emory Clin Cardiovascular Res Inst, Atlanta, GA USA.;Uppsala Univ, Uppsala Clin Res Ctr, Uppsala, Sweden.;Uppsala Univ, Dept Med Sci, Clin Chem, Uppsala, Sweden..
    Ko, Yi-An
    Hartiala, Jaana A.
    Univ Southern Calif, Los Angeles, CA USA.;Uppsala Univ, Dept Med Sci, Cardiol, Uppsala, Sweden..
    Allayee, Hooman
    Tang, W. H. Wilson
    Hazen, Stanley L.
    Heidelberg Univ, Dept Med, Mannheim, Germany..
    Eriksson, Niclas
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    Held, Claes
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    Hagström, Emil
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    Wallentin, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    Åkerblom, Axel
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    Siegbahn, A
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    Karp, Igor
    Univ Western Ontario, Schulich Sch Med & Dent, Dept Epidemiol & Biostat, London, England..
    Labos, Christopher
    Uppsala Univ, Dept Med Sci, Cardiol, Uppsala, Sweden.;McGill Univ, Dept Med, Montreal, PQ, Canada..
    Pilote, Louise
    McGill Univ, Dept Med, Montreal, PQ, Canada..
    Engert, James C.
    McGill Univ, Dept Med, Montreal, PQ, Canada..
    Brophy, James M.
    McGill Univ, Dept Med, Montreal, PQ, Canada.;Univ Laval, Dept Med, Laval, PQ, Canada..
    Thanassoulis, George
    McGill Univ, Dept Med, Montreal, PQ, Canada..
    Bogaty, Peter
    McGill Univ, Dept Med, Montreal, PQ, Canada..
    Szczeklik, Wojciech
    Uppsala Univ, Dept Med Sci, Cardiol, Uppsala, Sweden.;Jagielonian Univ, Coll Med, Krakow, Poland..
    Kaczor, Marcin
    Jagielonian Univ, Coll Med, Krakow, Poland..
    Sanak, Marek
    Jagielonian Univ, Coll Med, Krakow, Poland..
    Virani, Salim S.
    Baylor Coll Med, Cardiol Sect, Michael DeBakey Vet Affairs Med Ctr, Houston, TX USA..
    Ballantyne, Christie M.
    Baylor Coll Med, Sect Cardiovasc, Dept Med, Houston, TX USA..
    Lee, Vei-Vei
    Texas Heart Inst, Dept Biostat 7, Houston, TX USA..
    Boerwinkle, Eric
    Uppsala Univ, Dept Med Sci, Cardiol, Uppsala, Sweden.;Univ Texas Houston, Sch Publ Hlth, Houston, TX USA..
    Holmes, Michael V.
    Univ Oxford, Med Res Council Populat Hlth Res Unit, Oxford, England.;Univ Oxford, Natl Inst Hlth Res Oxford Biomed Res Ctr, Oxford, England..
    Horne, Benjamin D.
    Univ Oxford, Clin Trial Serv Unit, Oxford, England.;Univ Oxford, Epidemiol Studies Unit CTSU, Nuffield Dept Populat Hlth, Oxford, England..
    Hingorani, Aroon
    Asselbergs, Folkert W.
    Durrer Ctr Cardiogenet Res, ICIN, Utrecht, Netherlands..
    Patel, Riyaz S.
    Kraemer, Bernhard K.
    Scharnagl, Hubert
    Fliser, Danilo
    Maerz, Winfried
    Saarland Univ Hosp, Dept Internal Med 4, Homburg, Germany.;Synlab Acad, Synlab Holding, Mannheim, Germany..
    Speer, Thimoteus
    Relations between lipoprotein(a) concentrations, LPA genetic variants, and the risk of mortality in patients with established coronary heart disease: a molecular and genetic association study2017In: The Lancet Diabetes and Endocrinology, ISSN 2213-8587, E-ISSN 2213-8595, Vol. 5, no 7, p. 534-543Article in journal (Refereed)
    Abstract [en]

    Background: Lipoprotein(a) concentrations in plasma are associated with cardiovascular risk in the general population. Whether lipoprotein(a) concentrations or LPA genetic variants predict long-term mortality in patients with established coronary heart disease remains less clear.

    Methods: We obtained data from 3313 patients with established coronary heart disease in the Ludwigshafen Risk and Cardiovascular Health (LURIC) study. We tested associations of tertiles of lipoprotein(a) concentration in plasma and two LPA single-nucleotide polymorphisms ([SNPs] rs10455872 and rs3798220) with all-cause mortality and cardiovascular mortality by Cox regression analysis and with severity of disease by generalised linear modelling, with and without adjustment for age, sex, diabetes diagnosis, systolic blood pressure, BMI, smoking status, estimated glomerular filtration rate, LDL-cholesterol concentration, and use of lipid-lowering therapy. Results for plasma lipoprotein(a) concentrations were validated in five independent studies involving 10 195 patients with established coronary heart disease. Results for genetic associations were replicated through large-scale collaborative analysis in the GENIUS-CHD consortium, comprising 106 353 patients with established coronary heart disease and 19 332 deaths in 22 studies or cohorts.

    Findings: The median follow-up was 9.9 years. Increased severity of coronary heart disease was associated with lipoprotein(a) concentrations in plasma in the highest tertile (adjusted hazard radio [HR] 1.44, 95% CI 1.14-1.83) and the presence of either LPA SNP (1.88, 1.40-2.53). No associations were found in LURIC with all-cause mortality (highest tertile of lipoprotein(a) concentration in plasma 0.95, 0.81-1.11 and either LPA SNP 1.10, 0.92-1.31) or cardiovascular mortality (0.99, 0.81-1.2 and 1.13, 0.90-1.40, respectively) or in the validation studies.

    Interpretation: In patients with prevalent coronary heart disease, lipoprotein(a) concentrations and genetic variants showed no associations with mortality. We conclude that these variables are not useful risk factors to measure to predict progression to death after coronary heart disease is established.

  • 971. Zeymer, Uwe
    et al.
    James, Stefan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    Berkenboom, Guy
    Mohacsi, Attila
    Iñiguez, Andres
    Coufal, Zdenek
    Sartral, Magali
    Paget, Marie-Ange
    Norrbacka, Kirsi
    Ferrieres, Jean
    Bakhai, Ameet
    Differences in the use of guideline-recommended therapies among 14 European countries in patients with acute coronary syndromes undergoing PCI2013In: European Journal of Preventive Cardiology, ISSN 2047-4873, E-ISSN 2047-4881, Vol. 20, no 2, p. 218-228Article in journal (Refereed)
    Abstract [en]

    Aims:

    Despite common European Society of Cardiology recommendations, adherence to guideline therapy varies, both temporally and geographically. We sought to examine current differences in the use of guideline-recommended therapies among 14 European countries in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI).

    Methods and Results:

    Data were obtained from the Antiplatelet Therapy Observational Registry (APTOR), a non-interventional, prospective observational cohort study enrolling patients with ACS undergoing PCI. Medication data were captured through 1 year. The large majority of patients in the APTOR registry received statins at hospital discharge (89%) and remained on statins at 1 year (87%), a finding that was consistent across countries. Likewise, beta-blocker use was similar at discharge and 1 year (83 and 81%, respectively). There was large disparity in aspirin loading dose between countries, but the discharge maintenance dose was more consistent, with most receiving ≤100 mg (87%). While 95% of patients were discharged on dual antiplatelet therapy, 71% remained on both treatments by 1 year, with wide variation by country in 1-year use.

    Conclusions:

    These data from the APTOR study provide key information on current European ACS patient care management from hospitalization through 1 year. Even with European Society of Cardiology (ESC) guidelines, variations in practice patterns exist among ACS patients treated with PCI between the 14 European countries studied, including the use of proven therapies, as well as appropriate duration and dosing of antiplatelet regimens. Efforts are needed to further explain why such variation exists and to continue to improve adherence to ESC guidelines to improve patient care.

  • 972.
    Zhou, Bin
    et al.
    Univ London Imperial Coll Sci Technol & Med, London W2 1PG, England..
    Lu, Yuan
    Harvard Univ, TH Chan Sch Publ Hlth, Cambridge, MA 02138 USA..
    Hajifathalian, Kaveh
    Harvard Univ, TH Chan Sch Publ Hlth, Cambridge, MA 02138 USA..
    Bentham, James
    Univ London Imperial Coll Sci Technol & Med, London W2 1PG, England..
    Di Cesare, Mariachiara
    Univ London Imperial Coll Sci Technol & Med, London W2 1PG, England.;Middlesex Univ, London N17 8HR, England..
    Danaei, Goodarz
    Harvard Univ, TH Chan Sch Publ Hlth, Cambridge, MA 02138 USA..
    Bixby, Honor
    Univ London Imperial Coll Sci Technol & Med, London W2 1PG, England..
    Cowan, Melanie J.
    World Hlth Org, Geneva, Switzerland..
    Ali, Mohammed K.
    Emory Univ, Atlanta, GA 30322 USA..
    Taddei, Cristina
    Univ Florence, I-50121 Florence, Italy..
    Lo, Wei-Cheng
    Natl Taiwan Univ, Taipei, Taiwan..
    Reis-Santos, Barbara
    Univ Fed Pelotas, Pelotas, Brazil..
    Stevens, Gretchen A.
    World Hlth Org, Geneva, Switzerland..
    Riley, Leanne M.
    World Hlth Org, Geneva, Switzerland..
    Miranda, J. Jaime
    Univ Peruana Cayetano Heredia, Lima, Peru..
    Bjerregaard, Peter
    Univ Southern Denmark, Odense, Denmark. Univ Greenland, Manutooq, Greenland..
    Rivera, Juan A.
    Inst Nacl Salud Publ, Cuernavaca, Morelos, Mexico..
    Fouad, Heba M.
    World Hlth Org, Reg Off Eastern Mediterranean, Cairo, Egypt.;WHO, Reg Offi Eastern Mediterranean, Cairo, Egypt..
    Ma, Guansheng
    Peking Univ, Beijing, Peoples R China.;Peking Univ, Beijing, Peoples R China..
    Mbanya, Jean Claude N.
    Univ Yaounde I, Yaounde, Cameroon.;Univ Yaounde I, Yaounde, Cameroon..
    McGarvey, Stephen T.
    Brown Univ, Providence, RI 02912 USA.;Brown Univ, Providence, RI 02912 USA..
    Mohan, Viswanathan
    Madras Diabet Res Fdn, Madras, Tamil Nadu, India.;Madras Diabet Res Fdn, Madras, Tamil Nadu, India..
    Onat, Altan
    Istanbul Univ, Istanbul, Turkey.;Istanbul Univ, Istanbul, Turkey..
    Ramachandran, Ambady
    India Diabet Res Fdn, Madras, Tamil Nadu, India.;India Diabet Res Fdn, Delhi, India..
    Ben Romdhane, Habiba
    Univ Tunis El Manar, Tunis, Tunisia..
    Paciorek, Christopher J.
    Univ Calif Berkeley, Berkeley, CA 94720 USA..
    Bennett, James E.
    Univ London Imperial Coll Sci Technol & Med, London W2 1PG, England..
    Ezzati, Majid
    Univ London Imperial Coll Sci Technol & Med, London W2 1PG, England..
    Abdeen, Ziad A.
    Al Quds Univ, Jerusalem, Israel..
    Kadir, Khalid Abdul
    Monash Univ Malaysia, Selangor, Malaysia..
    Abu-Rmeileh, Niveen M.
    Birzeit Univ, Birzeit, Israel..
    Acosta-Cazares, Benjamin
    Inst Mexicano Seguro Social, Mexico City, DF, Mexico..
    Adams, Robert
    Univ Adelaide, Adelaide, SA 5005, Australia..
    Aekplakorn, Wichai
    Mahidol Univ, Bangkok 10700, Thailand..
    Aguilar-Salinas, Carlos A.
    Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Mexico City, DF, Mexico..
    Agyemang, Charles
    Univ Amsterdam, NL-1012 WX Amsterdam, Netherlands..
    Ahmadvand, Alireza
    Noncommunicable Dis Res Ctr, Tehran, Iran..
    Al-Othman, Amani Rashed
    Kuwait Inst Sci Res, Kuwait, Kuwait..
    Alkerwi, Ala'a
    Luxembourg Inst Hlth, Luxembourg, Luxembourg..
    Amouyel, Philippe
    Lille Univ & Hosp, Lille, France..
    Amuzu, Antoinette
    London Sch Hyg & Trop Med, London, England..
    Andersen, Lars Bo
    Univ Southern Denmark, Odense, Denmark. Univ Greenland, Manutooq, Greenland..
    Anderssen, Sigmund A.
    Norwegian Sch Sport Sci, Oslo, Norway..
    Anjana, Ranjit Mohan
    Madras Diabet Res Fdn, Madras, Tamil Nadu, India..
    Aounallah-Skhiri, Hajer
    Natl Inst Publ Hlth, Tunis, Tunisia..
    Aris, Tahir
    Minist Hlth Malaysia, Kuala Lumpur, Malaysia..
    Arlappa, Nimmathota
    Indian Council Med Res, New Delhi, India..
    Arveiler, Dominique
    Strasbourg Univ & Hosp, Strasbourg, France..
    Assah, Felix K.
    Univ Yaounde I, Yaounde, Cameroon..
    Avdicova, Maria
    Reg Author Publ Hlth, Banska Bystrica, Slovakia..
    Azizi, Fereidoun
    Shahid Beheshti Univ Med Sci, Tehran, Iran..
    Balakrishna, Nagalla
    Indian Council Med Res, New Delhi, India..
    Bandosz, Piotr
    Med Univ Gdansk, Gdansk, Poland..
    Barbagallo, Carlo M.
    Univ Palermo, I-90133 Palermo, Italy..
    Barcelo, Alberto
    Pan Amer Hlth Org, Washington, DC USA..
    Batieha, Anwar M.
    Jordan Univ Sci & Technol, Amman, Jordan..
    Baur, Louise A.
    Univ Sydney, Sydney, NSW 2006, Australia..
    Benet, Mikhail
    Univ Med Sci, Havana, Cuba..
    Bernabe-Ortiz, Antonio
    Univ Peruana Cayetano Heredia, Lima, Peru..
    Bharadwaj, Sumit
    Chirayu Med Coll, Bhopal, Madhya Pradesh, India..
    Bhargava, Santosh K.
    Sunder Lal Jain Hosp, New Delhi, India..
    Bi, Yufang
    Shanghai Jiao Tong Univ, Sch Med, Shanghai 200030, Peoples R China..
    Bjertness, Espen
    Univ Oslo, N-0316 Oslo, Norway..
    Bjertness, Marius B.
    Univ Oslo, N-0316 Oslo, Norway..
    Bjorkelund, Cecilia
    Univ Gothenburg, Gothenburg, Sweden..
    Blokstra, Anneke
    Natl Inst Publ Hlth & Environm, Amsterdam, Netherlands..
    Bo, Simona
    Univ Turin, I-10124 Turin, Italy..
    Boehm, Bernhard O.
    Nanyang Technol Univ, Singapore 639798, Singapore..
    Boissonnet, Carlos P.
    Ctr Educ Med & Invest Clin, Buenos Aires, DF, Argentina..
    Bovet, Pascal
    Minist Hlth, Mahe, Seychelles.;Univ Lausanne, CH-1015 Lausanne, Switzerland..
    Brajkovich, Imperia
    Cent Univ Venezuela, Caracas, Venezuela..
    Breckenkamp, Juergen
    Univ Bielefeld, Bielefeld, Germany..
    Brenner, Hermann
    German Canc Res Ctr, Berlin, Germany..
    Brewster, Lizzy M.
    Univ Amsterdam, NL-1012 WX Amsterdam, Netherlands..
    Brian, Garry R.
    Fred Hollows Fdn New Zealand, Wellington, New Zealand..
    Bruno, Graziella
    Univ Turin, I-10124 Turin, Italy..
    Bugge, Anna
    Univ Southern Denmark, Odense, Denmark. Univ Greenland, Manutooq, Greenland..
    Cabrera de Leon, Antonio
    Univ La Laguna, E-38207 San Cristobal la Laguna, Spain..
    Can, Gunay
    Istanbul Univ, Istanbul, Turkey..
    Candido, Ana Paula C.
    Univ Fed Juiz de Fora, Juiz De Fora, Brazil..
    Capuano, Vincenzo
    Cardiol Mercato S Severino, Milan, Italy..
    Carlsson, Axel C.
    Karolinska Inst, S-10401 Stockholm, Sweden..
    Carvalho, Maria J.
    Univ Porto, Rua Campo Alegre 823, P-4100 Oporto, Portugal..
    Casanueva, Felipe F.
    Univ Santiago de Compostela, Santiago De Compostela, Spain..
    Casas, Juan-Pablo
    UCL, London WC1E 6BT, England..
    Caserta, Carmelo A.
    Assoc Calabrese Epatol, Milan, Italy..
    Castetbon, Katia
    French Inst Hlth Surveillance, Paris, France..
    Chamukuttan, Snehalatha
    India Diabet Res Fdn, Madras, Tamil Nadu, India..
    Chaturvedi, Nishi
    UCL, London WC1E 6BT, England..
    Chen, Chien-Jen
    Acad Sinica, Taipei, Taiwan..
    Chen, Fangfang
    Capital Inst Pediat, Beijing, Peoples R China..
    Chen, Shuohua
    Kailuan Gen Hosp, Beijing, Peoples R China..
    Cheng, Ching-Yu
    Duke NUS Grad Med Sch, Singapore, Singapore..
    Chetrit, Angela
    Gertner Inst Epidemiol & Hlth Policy Res, Haifa, Israel..
    Chiou, Shu-Ti
    Minist Hlth & Welf, Taipei, Taiwan..
    Cho, Yumi
    Korea Ctr Dis Control & Prevent, Seoul, South Korea..
    Chudek, Jerzy
    Med Univ Silesia, Poznan, Poland..
    Cifkova, Renata
    Charles Univ Prague, Prague, Czech Republic..
    Claessens, Frank
    Katholieke Univ Leuven, Leuven, Belgium..
    Concin, Hans
    Agcy Prevent & Social Med, Bregenz, Austria..
    Cooper, Cyrus
    Univ Southampton, Southampton SO9 5NH, Hants, England..
    Cooper, Rachel
    UCL, London WC1E 6BT, England..
    Costanzo, Simona
    IRCCS Ist Neurol Mediterraneo Neuromed, Milan, Italy..
    Cottel, Dominique
    Inst Pasteur, Lille, France..
    Cowell, Chris
    Univ Western Sydney, Penrith, NSW 1797, Australia..
    Crujeiras, Ana B.
    CIBEROBN, Barcelona, Spain..
    D'Arrigo, Graziella
    CNR, Milan, Italy..
    Dallongeville, Jean
    Inst Pasteur, Lille, France..
    Dankner, Rachel
    Gertner Inst Epidemiol & Hlth Policy Res, Haifa, Israel..
    Dauchet, Luc
    Lille Univ Hosp, Lille, France..
    de Gaetano, Giovanni
    IRCCS Ist Neurol Mediterraneo Neuromed, Milan, Italy..
    De Henauw, Stefaan
    Univ Ghent, B-9000 Ghent, Belgium..
    Deepa, Mohan
    Madras Diabet Res Fdn, Madras, Tamil Nadu, India..
    Dehghan, Abbas
    Erasmus MC, Rotterdam, Netherlands..
    Deschamps, Valerie
    French Inst Hlth Surveillance, Paris, France.;French Inst Hlth Surveillance, Paris, France..
    Dhana, Klodian
    Erasmus MC, Rotterdam, Netherlands..
    Di Castelnuovo, Augusto F.
    IRCCS Ist Neurol Mediterraneo Neuromed, Milan, Italy.;IRCCS Ist Neurol Mediterraneo Neuromed, Milan, Italy..
    Djalalinia, Shirin
    Noncommunicable Dis Res Ctr, Tehran, Iran.;Noncommunicable Dis Res Ctr, Tehran, Iran..
    Doua, Kouamelan
    Minist Sante & Lutte Contre Sida, Abidjan, Cote Ivoire..
    Drygas, Wojciech
    Cardinal Wyszynski Inst Cardiol, Poznan, Poland..
    Du, Yong
    Robert Koch Inst, Berlin, Germany..
    Dzerve, Vilnis
    Latvian State Univ, Riga, Latvia..
    Egbagbe, Eruke E.
    Univ Benin, Benin, Nigeria..
    Eggertsen, Robert
    Univ Gothenburg, Gothenburg, Sweden..
    El Ati, Jalila
    Natl Inst Nutr & Food Technol, Tunis, Tunisia..
    Elosua, Roberto
    Inst Hosp Mar Invest Med, Barcelona, Spain..
    Erasmus, Rajiv T.
    Univ Stellenbosch, ZA-7600 Stellenbosch, South Africa..
    Erem, Cihangir
    Karadeniz Tech Univ, Ankara, Turkey..
    Ergor, Gul
    Dokuz Eylul Univ, TR-35210 Alsancak, Turkey..
    Eriksen, Louise
    Univ So Denmark, Copenhagen, Denmark..
    Escobedo-de la Pena, Jorge
    Inst Mexicano Seguro Social, Mexico City, DF, Mexico..
    Fall, Caroline H.
    Univ Southampton, Southampton SO9 5NH, Hants, England..
    Farzadfar, Farshad
    Univ Tehran Med Sci, Tehran, Iran..
    Felix-Redondo, Francisco J.
    Ctr Salud Villanueva Norte, Barcelona, Spain..
    Ferguson, Trevor S.
    Univ W Indies, Kingston, Jamaica..
    Fernandez-Berges, Daniel
    Hosp Don Benito Villanueva Serena, Barcelona, Spain..
    Ferrari, Marika
    Council Agr Res & Econ, Milan, Italy..
    Ferreccio, Catterina
    Pontificia Univ Catolica Chile, Santiago, Chile..
    Feskens, Edith J. M.
    Wageningen Univ, NL-6700 AP Wageningen, Netherlands..
    Finn, Joseph D.
    Univ Manchester, Manchester M13 9PL, Lancs, England..
    Foeger, Bernhard
    Agcy Prevent & Social Med, Innsbruck, Austria..
    Foo, Leng Huat
    Univ Sains Malaysia, Kuala Lumpur, Malaysia..
    Forslund, Ann-Sofie
    Univ Lulea, S-97187 Lulea, Sweden..
    Francis, Damian K.
    Univ W Indies, Kingston, Jamaica..
    Franco, Maria do Carmo
    Univ Fed Sao Paulo, Sao Paulo, Brazil..
    Franco, Oscar H.
    Erasmus MC, Rotterdam, Netherlands..
    Frontera, Guillermo
    Hosp Univ Son Espases, Barcelona, Spain..
    Furusawa, Takuro
    Kyoto Univ, Kyoto 6068501, Japan..
    Gaciong, Zbigniew
    Med Univ Warsaw, Warsaw, Poland..
    Garnett, Sarah P.
    Univ Sydney, Sydney, NSW 2006, Australia..
    Gaspoz, Jean-Michel
    Univ Hosp Geneva, Geneva, Switzerland..
    Gasull, Magda
    CIBER Epidemiol & Salud Publ, Barcelona, Spain..
    Gates, Louise
    Australian Bur Stat, Melbourne, Vic, Australia..
    Geleijnse, Johanna M.
    Wageningen Univ, NL-6700 AP Wageningen, Netherlands..
    Ghasemian, Anoosheh
    Noncommunicable Dis Res Ctr, Tehran, Iran..
    Ghimire, Anup
    BP Koirala Inst Hlth Sci, Kathmandu, Nepal..
    Giampaoli, Simona
    Ist Super Sanita, Milan, Italy..
    Gianfagna, Francesco
    Univ Insubria, Insubria, Italy..
    Giovannelli, Jonathan
    Lille Univ Hosp, Lille, France..
    Giwercman, Aleksander
    Lund Univ, S-22100 Lund, Sweden..
    Gonzalez Gross, Marcela
    Univ Politecn Madrid, E-28040 Madrid, Spain..
    Gonzalez Rivas, Juan P.
    Andes Clin Cardiometab Studies, Maracaibo, Venezuela..
    Bonet Gorbea, Mariano
    Natl Inst Hyg Epidemiol & Microbiol, Havana, Cuba..
    Gottrand, Frederic
    Univ Lille 2, F-59800 Lille, France..
    Grafnetter, Dusan
    Inst Clin & Expt Med, Prague, Czech Republic..
    Grodzicki, Tomasz
    Jagiellonian Univ, Coll Med, PL-31007 Krakow, Poland..
    Grontved, Anders
    Univ So Denmark, Odense, Denmark..
    Gruden, Grabriella
    Univ Turin, I-10124 Turin, Italy..
    Gu, Dongfeng
    Natl Ctr Cardiovasc Dis, Beijing, Peoples R China..
    Guan, Ong Peng
    Singapore Eye Res Inst, Singapore, Singapore..
    Guerrero, Ramiro
    Univ Icesi, Cali, Colombia..
    Guessous, Idris
    Univ Hosp Geneva, Geneva, Switzerland..
    Guimaraes, Andre L.
    Univ Estadual Montes Claros, Montes Claros, Brazil..
    Gutierrez, Laura
    Inst Clin Effectiveness & Hlth Policy, Buenos Aires, DF, Argentina..
    Hambleton, Ian R.
    Univ W Indies, Kingston, Jamaica..
    Hardy, Rebecca
    UCL, London WC1E 6BT, England..
    Kumar, Rachakulla Hari
    Indian Council Med Res, New Delhi, India..
    Hata, Jun
    Kyushu Univ, Fukuoka 812, Japan. Tulane Univ, New Orleans, LA 70118 USA..
    Heidemann, Christin
    Robert Koch Inst, Berlin, Germany..
    Herrala, Sauli
    Oulu Univ Hosp, Oulu, Finland..
    Hihtaniemi, Ilpo Tapani
    Imperial Coll London, London, England..
    Ho, Sai Yin
    Univ Hong Kong, Hong Kong, Peoples R China..
    Ho, Suzanne C.
    Chinese Univ Hong Kong, Hong Kong, Peoples R China..
    Hofman, Albert
    Erasmus MC, Rotterdam, Netherlands..
    Hormiga, Claudia M.
    Fdn Oftalmol Santander, Santander, Spain..
    Horta, Bernardo L.
    Univ Fed Pelotas, Pelotas, Brazil..
    Houti, Leila
    Univ Oran 1, Oran, Algeria..
    Howitt, Christina
    Univ W Indies, Kingston, Jamaica..
    Htay, Thein Thein
    Minist Hlth, Naypyidaw, Myanmar..
    Htet, Aung Soe
    Univ Oslo, N-0316 Oslo, Norway..
    Htike, Maung Maung Than
    Minist Hlth, Naypyidaw, Myanmar..
    Hu, Yang
    Harvard Univ, TH Chan Sch Publ Hlth, Cambridge, MA 02138 USA..
    Hussieni, Abdullatif S.
    Birzeit Univ, Birzeit, Israel..
    Huybrechts, Inge
    Int Agcy Res Canc, Lyon, France..
    Hwalla, Nahla
    Amer Univ Beirut, Beirut, Lebanon..
    Iacoviello, Licia
    IRCCS Ist Neurol Mediterraneo Neuromed, Milan, Italy..
    Iannone, Anna G.
    Cardiol Mercato S Severino, Milan, Italy..
    Ibrahim, M. Mohsen
    Cairo Univ, Cairo, Egypt..
    Ikeda, Nayu
    Natl Inst Hlth & Nutr, Tokyo, Japan..
    Ikram, M. Arfan
    Erasmus MC, Rotterdam, Netherlands..
    Irazola, Vilma E.
    Inst Clin Effectiveness & Hlth Policy, Buenos Aires, DF, Argentina..
    Islam, Muhammad
    Aga Khan Univ, Karachi, Pakistan..
    Iwasaki, Masanori
    Niigata Univ, Niigata 95021, Japan..
    Jacobs, Jeremy M.
    Hadassah Univ, Med Ctr, Jerusalem, Israel..
    Jafar, Tazeen
    Duke NUS Grad Med Sch, Singapore, Singapore..
    Jamil, Kazi M.
    Kuwait Inst Sci Res, Kuwait, Kuwait..
    Jasienska, Grazyna
    Jagiellonian Univ, Coll Med, PL-31007 Krakow, Poland..
    Jiang, Chao Qiang
    Univ Hong Kong, Hong Kong, Peoples R China..
    Jonas, Jost B.
    Heidelberg Univ, Heidelberg, Germany..
    Joshi, Pradeep
    WHO, Country Off, New Delhi, India..
    Kafatos, Anthony
    Univ Crete, Iraklion, Greece..
    Kalter-Leibovici, Ofra
    Gertner Inst Epidemiol & Hlth Policy Res, Jerusalem, Israel..
    Kasaeian, Amir
    Noncommunicable Dis Res Ctr, Tehran, Iran..
    Katz, Joanne
    Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA..
    Kaur, Prabhdeep
    Natl Inst Epidemiol, New Delhi, India..
    Kavousi, Maryam
    Erasmus MC, Rotterdam, Netherlands. Oulu Univ Hosp, Oulu, Finland..
    Kelishadi, Roya
    Res Inst Primordial Prevent Noncommunicable Dis, Tehran, Iran..
    Kengne, Andre P.
    South African Med Res Council, Cape Town, South Africa..
    Kersting, Mathilde
    Res Inst Child Nutr, Dortmund, Germany..
    Khader, Yousef Saleh
    Jordan Univ Sci & Technol, Irbid, Jordan..
    Khalili, Davood
    Shahid Beheshti Univ Med Sci, Tehran, Iran..
    Khang, Young-Ho
    Seoul Natl Univ, Seoul 151, South Korea..
    Kiechl, Stefan
    Med Univ Innsbruck, A-6020 Innsbruck, Austria..
    Kim, Jeongseon
    Natl Canc Ctr, Goyang, South Korea..
    Kolsteren, Patrick
    Inst Trop Med, Antwerp, Belgium. Tartu Univ Clin, Tartu, Estonia..
    Kratzer, Wolfgang
    Univ Hosp Ulm, Ulm, Germany..
    Kromhout, Daan
    Wageningen Univ, NL-6700 AP Wageningen, Netherlands..
    Kujala, Urho M.
    Univ Jyvaskyla, SF-40351 Jyvaskyla, Finland..
    Kula, Krzysztof
    Med Univ Lodz, Lodz, Poland..
    Kyobutungi, Catherine
    African Populat & Hlth Res Ctr, Nairobi, Kenya..
    Laatikainen, Tiina
    Natl Inst Hlth & Welf, Helsinki, Finland..
    Lachat, Carl
    Univ Ghent, B-9000 Ghent, Belgium..
    Laid, Youcef
    INSP, Algiers, Algeria..
    Lam, Tai Hing
    Univ Hong Kong, Hong Kong, Hong Kong, Peoples R China..
    Landrove, Orlando
    Minist Salud Publ, Havana, Cuba..
    Lanska, Vera
    Inst Clin & Expt Med, Prague, Czech Republic..
    Lappas, Georg
    Sahlgrens Acad, Gothenburg, Sweden..
    Laxmaiah, Avula
    Indian Council Med Res, New Delhi, India..
    Leclercq, Catherine
    Food & Agr Org, Rome, Italy..
    Lee, Jeannette
    Natl Univ Singapore, Singapore 117548, Singapore..
    Lee, Jeonghee
    Natl Canc Ctr, Goyang, South Korea..
    Lehtimaki, Terho
    Tampere Univ Hosp, Tampere, Finland..
    Lekhraj, Rampal
    Univ Putra Malaysia, Serdang 43400, Malaysia..
    Leon-Munoz, Luz M.
    Univ Autonoma Madrid, E-28049 Madrid, Spain..
    Li, Yanping
    Harvard Univ, TH Chan Sch Publ Hlth, Cambridge, MA 02138 USA..
    Lim, Wei-Yen
    Natl Univ Singapore, Singapore 117548, Singapore..
    Fernanda Lima-Costa, M.
    Fundacao Oswaldo Cruz, Rene Rachou Res Inst, Recife, PE, Brazil..
    Lin, Hsien-Ho
    Natl Taiwan Univ, Taipei, Taiwan..
    Lin, Xu
    Univ Chinese Acad Sci, Beijing, Peoples R China..
    Lissner, Lauren
    Univ Gothenburg, Gothenburg, Sweden..
    Lorbeer, Roberto
    Univ Med Greifswald, Greifswald, Germany..
    Eugenio Lozano, Jose
    Consejeria Sanidad Junta Castilla & Leon, Madrid, Spain..
    Luksiene, Dalia
    Lithuanian Univ Hlth Sci, Kaunas, Lithuania..
    Lundqvist, Annamari
    Natl Inst Hlth & Welf, Helsinki, Finland..
    Lytsy, Per
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Machado-Coelho, George L. L.
    Univ Fed Ouro Preto, Ouro Preto, Brazil..
    Machi, Suka
    Jikei Univ, Sch Med, Tokyo, Japan..
    Maggi, Stefania
    CNR, Rome, Italy..
    Magliano, Dianna J.
    Baker IDI Heart & Diabet Inst, Melbourne, Vic, Australia..
    Makdisse, Marcia
    Hosp Israelita Albert Einstein, Sao Paulo, Brazil..
    Rao, Kodavanti Mallikharjuna
    Indian Council Med Res, New Delhi, India..
    Manios, Yannis
    Harokopio Univ, Kallithea, Greece..
    Manzato, Enzo
    Univ Padua, I-35100 Padua, Italy..
    Margozzini, Paula
    Pontificia Univ Catolica Chile, Santiago, Chile..
    Marques-Vidal, Pedro
    Univ Lausanne Hosp, Lausanne, Switzerland..
    Martorell, Reynaldo
    Emory Univ, Atlanta, GA 30322 USA..
    Masoodi, Shariq R.
    Sherikashmir Inst Med Sci, Srinagar, Jammu & Kashmir, India..
    Mathiesen, Ellisiv B.
    UiT Arct Univ Norway, Tromso, Norway..
    Matsha, Tandi E.
    Cape Peninsula Univ Technol, Cape Town, South Africa..
    McFarlane, Shelly R.
    Univ W Indies, Kingston, Jamaica..
    McLachlan, Stela
    Univ Edinburgh, Edinburgh EH8 9YL, Midlothian, Scotland..
    McNulty, Breige A.
    Univ Coll Dublin, Dublin 2, Ireland..
    Mediene-Benchekor, Sounnia
    Univ Oran 1, Es Senia, Algeria..
    Meirhaeghe, Aline
    INSERM, F-75654 Paris 13, France..
    Menezes, Ana Maria B.
    Univ Fed Pelotas, Pelotas, Brazil..
    Merat, Shahin
    Digest Dis Res Inst, Tehran, Iran..
    Meshram, Indrapal I.
    Indian Council Med Res, New Delhi, India..
    Mi, Jie
    Capital Inst Pediat, Beijing, Peoples R China..
    Francisco Miquel, Juan
    Pontificia Univ Catolica Chile, Santiago, Chile..
    Jaime Miranda, J.
    Univ Peruana Cayetano Heredia, Lima, Peru..
    Mohamed, Mostafa K.
    Ain Shams Univ, Cairo, Egypt..
    Mohammad, Kazem
    Univ Tehran Med Sci, Tehran, Iran..
    Mohammadifard, Noushin
    Isfahan Cardiovasc Res Ctr, Tehran, Iran..
    Yusoff, Muhammad Fadhli Mohd
    Minist Hlth Malaysia, Kuala Lumpur, Malaysia..
    Moller, Niels C.
    Univ So Denmark, Odense, Denmark..
    Molnar, Denes
    Univ Pecs, Pecs, Hungary..
    Mondo, Charles K.
    Mulago Hosp, Kampala, Uganda..
    Morejon, Alain
    Univ Med Sci, Havana, Cuba..
    Moreno, Luis A.
    Univ Zaragoza, E-50009 Zaragoza, Spain..
    Morgan, Karen
    RCSI Dublin, Dublin, Ireland..
    Moschonis, George
    Harokopio Univ, Kallithea, Greece..
    Mossakowska, Malgorzata
    Int Inst Mol & Cell Biol, Warsaw, Poland..
    Mostafa, Aya
    Ain Shams Univ, Cairo, Egypt..
    Mota, Jorge
    Univ Porto, Rua Campo Alegre 823, P-4100 Oporto, Portugal..
    Motta, Jorge
    Gorgas Mem Inst Publ Hlth, Panama City, Panama..
    Mu, Thet Thet
    Dept Publ Hlth, Naypyidaw, Myanmar..
    Muiesan, Maria Lorenza
    Univ Brescia, Brescia, Italy..
    Mueller-Nurasyid, Martina
    Helmholtz Zentrum Munchen, Munich, Germany..
    Mursu, Jaakko
    Univ Eastern Finland, Joensuu, Finland..
    Nagel, Gabriele
    Univ Ulm, D-89069 Ulm, Germany..
    Namesna, Jana
    Reg Author Publ Hlth, Banska Bystrica, Slovakia..
    Nang, Ei Ei K.
    Natl Univ Singapore, Singapore 117548, Singapore..
    Nangia, Vinay B.
    Suraj Eye Inst, Nagpur, Maharashtra, India..
    Maria Navarrete-Munoz, Eva
    CIBER Epidemiol & Salud Publ, Barcelona, Spain..
    Ndiaye, Ndeye Coumba
    INSERM, F-75654 Paris 13, France..
    Nenko, Ilona
    Jagiellonian Univ, Coll Med, PL-31007 Krakow, Poland..
    Nervi, Flavio
    Pontificia Univ Catolica Chile, Santiago, Chile..
    Nguyen, Nguyen D.
    Univ Pharm & Med Ho Chi Minh City, Ho Chi Minh City, Vietnam..
    Nguyen, Quang Ngoc
    Nieto-Martinez, Ramfi S. E.
    Univ Ctr Occidental Lisandro Alvarado, Caracas, Venezuela..
    Ning, Guang
    Shanghai Jiao Tong Univ, Sch Med, Shanghai 200030, Peoples R China..
    Ninomiya, Toshiharu
    Kyushu Univ, Fukuoka 812, Japan..
    Noale, Marianna
    CNR, Milan, Italy..
    Noto, Davide
    Univ Palermo, Palermo, Italy..
    Al Nsour, Mohannad
    Eastern Mediterranean Publ Hlth Network, Amman, Jordan..
    Ochoa-Aviles, Angelica M.
    Univ Cuenca, Cuenca, Ecuador..
    Oh, Kyungwon
    Korea Ctr Dis Control & Prevent, Seoul, South Korea..
    Ordunez, Pedro
    Pan Amer Hlth Org, Washington, DC USA..
    Osmond, Clive
    MRC Lifecourse Epidemiol Unit, Southampton, Hants, England..
    Otero, Johanna A.
    Fdn Oftalmol Santander, Santander, Colombia..
    Owusu-Dabo, Ellis
    Kwame Nkrumah Univ Sci & Technol, Kumasi, Ghana..
    Pahomova, Elena
    Univ Latvia, Riga, Latvia..
    Palmieri, Luigi
    Ist Super Sanita, Milan, Italy..
    Panda-Jonas, Songhomitra
    Heidelberg Univ, Heidelberg, Germany..
    Panza, Francesco
    Univ Bari, Bari, Italy..
    Parsaeian, Mahboubeh
    Noncommunicable Dis Res Ctr, Tehran, Iran..
    Peixoto, Sergio Viana
    Fundacao Oswaldo Cruz, Rene Rachou Res Inst, Rio De Janeiro, Brazil..
    Peltonen, Markku
    Natl Inst Hlth & Welf, Helsinki, Finland..
    Peters, Annette
    Helmholtz Zentrum Munchen, Munich, Germany..
    Peykari, Niloofar
    Noncommunicable Dis Res Ctr, Tehran, Iran..
    Pham, Son Thai
    Pilav, Aida
    Fed Minist Hlth, Sarajevo, Bosnia & Herceg.;Fed Minist Hlth, Mostar, Bosnia & Herceg..
    Pitakaka, Freda
    Univ New S Wales, Sydney, NSW 2052, Australia..
    Piwonska, Aleksandra
    Cardinal Wyszynski Inst Cardiol, Warsaw, Poland..
    Piwonski, Jerzy
    Cardinal Wyszynski Inst Cardiol, Warsaw, Poland..
    Plans-Rubio, Pedro
    Publ Hlth Agcy Catalonia, Catalonia, Spain..
    Porta, Miquel
    Inst Hosp Mar Invest Med, Madrid, Spain..
    Portegies, Marileen L. P.
    Erasmus MC, Rotterdam, Netherlands..
    Poustchi, Hossein
    Univ Tehran Med Sci, Tehran, Iran..
    Pradeepa, Rajendra
    Madras Diabet Res Fdn, Madras, Tamil Nadu, India..
    Price, Jacqueline F.
    Univ Edinburgh, Edinburgh, Midlothian, Scotland..
    Punab, Margus
    Tartu Univ Clin, Tartu, Estonia..
    Qasrawi, Radwan F.
    Qorbani, Mostafa
    Alborz Univ Med Sci, Alborz, Iran..
    Radisauskas, Ricardas
    Lithuanian Univ Hlth Sci, Kaunas, Lithuania..
    Rahman, Mahmudur
    Raitakari, Olli
    Univ Turku, Turku, Finland..
    Rao, Sudha Ramachandra
    Natl Inst Epidemiol, Delhi, India..
    Ramke, Jacqueline
    Univ New S Wales, Sydney, NSW 2052, Australia..
    Ramos, Rafel
    Inst Univ Invest Atencio Primaria Jordi Gol, Barcelona, Spain..
    Rampal, Sanjay
    Univ Malaya, Kuala Lumpur, Malaysia..
    Rathmann, Wolfgang
    German Diabet Ctr, Berlin, Germany..
    Redon, Josep
    Univ Valencia, Valencia, Spain..
    Reganit, Paul Ferdinand M.
    Univ Philippines, Quezon City 1101, Philippines..
    Rigo, Fernando
    Hlth Ctr San Agustin, San Agustin, Spain..
    Robinson, Sian M.
    Univ Southampton, Southampton SO9 5NH, Hants, England..
    Robitaille, Cynthia
    Publ Hlth Agcy Canada, Toronto, ON, Canada..
    Rodriguez-Artalejo, Fernando
    Univ Autonoma Madrid, Madrid, Spain..
    del Cristo Rodriguez-Perez, Maria
    Rodriguez-Villamizar, Laura A.
    Univ Ind Santander, Santander, Colombia..
    Rojas-Martinez, Rosalba
    Inst Nacl Salud Publ, Mexico City, DF, Mexico..
    Ronkainen, Kimmo
    Rosengren, Annika
    Univ Gothenburg, Gothenburg, Sweden..
    Rubinstein, Adolfo
    Inst Clin Effectiveness & Hlth Policy, Buenos Aires, DF, Argentina..
    Rui, Ornelas
    Univ Madeira, Funchal, Portugal..
    Sandra Ruiz-Betancourt, Blanca
    Inst Mexicano Seguro Social, Mexico City, DF, Mexico..
    Russo Horimoto, Andrea R. V.
    Inst Heart, Sao Paulo, Brazil..
    Rutkowski, Marcin
    Med Univ Gdansk, Gdansk, Poland..
    Sabanayagam, Charumathi
    Singapore Eye Res Inst, Singapore, Singapore..
    Sachdev, Harshpal S.
    Sitaram Bhartia Inst Sci & Res, Delhi, India..
    Saidi, Olfa
    Univ Tunis El Manar, Tunis, Tunisia..
    Sakarya, Sibel
    Marmara Univ, Istanbul, Turkey..
    Salanave, Benoit
    French Inst Hlth Surveillance, Paris, France..
    Salonen, Jukka T.
    Univ Helsinki, Helsinki, Finland..
    Salvetti, Massimo
    Univ Brescia, Brescia, Italy..
    Sanchez-Abanto, Jose
    Santos, Diana
    Univ Lisbon, P-1699 Lisbon, Portugal..
    dos Santos, Renata Nunes
    Univ Sao Paulo, Clin Hosp, BR-05508 Sao Paulo, Brazil..
    Santos, Rute
    Univ Porto, Rua Campo Alegre 823, P-4100 Oporto, Portugal..
    Saramies, Jouko L.
    Sardinha, Luis B.
    Univ Lisbon, P-1699 Lisbon, Portugal..
    Sarrafzadegan, Nizal
    Isfahan Cardiovasc Res Ctr, Esfahan, Iran..
    Saum, Kai-Uwe
    German Canc Res Ctr, Berlin, Germany..
    Scazufca, Marcia
    Univ Sao Paulo, Clin Hosp, BR-05508 Sao Paulo, Brazil..
    Schargrodsky, Herman
    Hosp Italiano Buenos Aires, Buenos Aires, DF, Argentina..
    Scheidt-Nave, Christa
    Robert Koch Inst, Berlin, Germany..
    Sein, Aye Aye
    Sharma, Sanjb K.
    Shaw, Jonathan E.
    Shibuya, Kenji
    Univ Tokyo, Tokyo, Japan..
    Shin, Youchan
    Singapore Eye Res Inst, Singapore, Singapore..
    Shiri, Rahman
    Siantar, Rosalynn
    Singapore Eye Res Inst, Singapore, Singapore..
    Sibai, Abla M.
    Amer Univ Beirut, Beirut, Lebanon..
    Simon, Mary
    Simons, Judith
    Simons, Leon A.
    Univ New S Wales, Sydney, NSW 2052, Australia..
    Sjostrom, Michael
    Karolinska Inst, S-10401 Stockholm, Sweden..
    Slowikowska-Hilczer, Jolanta
    Med Univ Lodz, Lodz, Poland..
    Slusarczyk, Przemyslaw
    Smeeth, Liam
    London Sch Hyg & Trop Med, London, England..
    Snijder, Marieke B.
    Univ Amsterdam, Acad Med Ctr, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands..
    So, Hung-Kwan
    Chinese Univ Hong Kong, Hong Kong, Hong Kong, Peoples R China..
    Sobngwi, Eugene
    Univ Yaounde I, Yaounde, Cameroon..
    Soderberg, Stefan
    Umea Univ, Umea, Sweden..
    Solfrizzi, Vincenzo
    Univ Bari, Bari, Italy..
    Sonestedt, Emily
    Lund Univ, Lund, Sweden..
    Soumare, Aicha
    Univ Bordeaux, Bordeaux, France..
    Staessen, Jan A.
    Univ Leuven, Leuven, Belgium..
    Stathopoulou, Maria G.
    INSERM, F-75654 Paris 13, France..
    Steene-Johannessen, Jostein
    Stehle, Peter
    Univ Bonn, Bonn, Germany..
    Stein, Aryeh D.
    Emory Univ, Atlanta, GA 30322 USA..
    Stessman, Jochanan
    Hadassah Univ, Med Ctr, Jerusalem, Israel..
    Stoeckl, Doris
    Helmholtz Zentrum mUNCHEN, Munich, Germany..
    Stokwiszewski, Jakub
    Stronks, Karien
    Univ Amsterdam, Amsterdam, Netherlands..
    Strufaldi, Maria Wany
    Univ Fed Sao Paulo, Sao Paulo, Brazil..
    Sun, Chien-An
    Fu Jen Catholic Univ, Taipei, Taiwan..
    Sundström, Johan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    Sung, Yn-Tz
    Chinese Univ Hong Kong, Hong Kong, Hong Kong, Peoples R China..
    Suriyawongpaisal, Paibul
    Mahidol Univ, Bangkok 10700, Thailand..
    Sy, Rody G.
    Univ Philippines, Quezon City 1101, Philippines..
    Tai, E. Shyong
    Natl Univ Singapore, Singapore 117548, Singapore..
    Tamosiunas, Abdonas
    Tang, Line
    Tarawneh, Mohammed
    Tarqui-Mamani, Carolina B.
    Taylor, Anne
    Univ Adelaide, Adelaide, SA 5005, Australia..
    Theobald, Holger
    Karolinska Inst, S-10401 Stockholm, Sweden..
    Thijs, Lutgarde
    Univ Leuven, Leuven, Belgium..
    Thuesen, Betina H.
    Tolonen, Hanna K.
    Tolstrup, Janne S.
    Topbas, Murat
    Torrent, Maties
    Traissac, Pierre
    Trinh, Oanh T. H.
    Univ Pharm & Med Ho Chi Minh City, Ho Chi Minh City, Vietnam..
    Tulloch-Reid, Marshall K.
    Univ W Indies, Kingston, Jamaica..
    Tuomainen, Tomi-Pekka
    Univ Eastern Finland, Joensuu, Finland..
    Turley, Maria L.
    Tzourio, Christophe
    Univ Bordeaux, Bordeaux, France..
    Ueda, Peter
    Harvard Univ, TH Chan Sch Publ Hlth, Cambridge, MA 02138 USA..
    Ukoli, Flora A. M.
    Meharry Med Coll, Nashville, TN USA..
    Ulmer, Hanno
    Med Univ Innsbruck, A-6020 Innsbruck, Austria..
    Uusitalo, Hannu M. T.
    Tampere Univ Hosp, Tampere, Finland..
    Valdivia, Gonzalo
    Pontificia Univ Catolica Chile, Santiago, Chile..
    Valvi, Damaskini
    Harvard Univ, TH Chan Sch Publ Hlth, Cambridge, MA 02138 USA..
    van Rossem, Lenie
    Univ Med Ctr Utrecht, Utrecht, Netherlands..
    van Valkengoed, Irene G. M.
    Univ Amsterdam, Acad Med Ctr, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands..
    Vanderschueren, Dirk
    Katholieke Univ Leuven, Leuven, Belgium..
    Vanuzzo, Diego
    Ctr Prevenz Cardiovasc Udine, Udine, Italy..
    Vega, Tomas
    Consejeria Sanidad Junta Castilla & Leon, Leon, Spain..
    Velasquez-Melendez, Gustavo
    Univ Fed Minas Gerais, Belo Horizonte, MG, Brazil..
    Veronesi, Giovanni
    Univ Insubria, Insubria, Italy..
    Verschuren, W. M. Monique
    Natl Inst Publ Hlth & Environm, Amsterdam, Netherlands..
    Verstraeten, Roosmarijn
    Inst Trop Med, Brussels, Belgium..
    Viet, Lucie
    Natl Inst Publ Hlth & Environm, Amsterdam, Netherlands..
    Vioque, Jesus
    Univ Miguel Hernandez, Elche, Spain..
    Virtanen, Jyrki K.
    Univ Eastern Finland, Joensuu, Finland. INSERM, F-75654 Paris 13, France..
    Viswanathan, Bharathi
    Minist Hlth, Victoria, Seychelles..
    Vollenweider, Peter
    Univ Lausanne Hosp, Lausanne, Switzerland..
    Voutilainen, Sari
    Univ Eastern Finland, Tampere, Finland..
    Vrijheid, Martine
    Ctr Res Environm Epidemiol, Barcelona, Spain..
    Wade, Alisha N.
    Univ Witwatersrand, ZA-2050 Johannesburg, South Africa..
    Wagner, Aline
    Univ Strasbourg, Strasbourg, France..
    Walton, Janette
    Univ Coll Cork, Cork, Ireland..
    Mohamud, Wan Nazaimoon Wan
    Inst Med Res, Kuala Lumpur, Malaysia..
    Wang, Feng
    Peking Univ, Hosp 6, Beijing, Peoples R China..
    Wang, Ming-Dong
    Publ Hlth Agcy Canada, Toronto, ON, Canada..
    Wang, Qian
    Xinjiang Med Univ, Urumqi, Xinjiang, Peoples R China..
    Wang, Ya Xing
    Beijing Tongren Hosp, Beijing, Peoples R China..
    Wannamethee, S. Goya
    UCL, London WC1E 6BT, England..
    Weerasekera, Deepa
    Minist Hlth, Auckland, New Zealand..
    Whincup, Peter H.
    St Georges Univ London, London, England..
    Widhalm, Kurt
    Med Univ Vienna, Vienna, Austria. Med Univ Silesia, Katowice, Poland. Natl Inst Publ Hlth & Environm, Amsterdam, Netherlands..
    Wijga, Alet H.
    Wilks, Rainford J.
    Univ W Indies, Kingston, Jamaica..
    Willeit, Johann
    Med Univ Innsbruck, A-6020 Innsbruck, Austria..
    Wilsgaard, Tom
    UiT Arct Univ Norway, Oslo, Norway..
    Wojtyniak, Bogdan
    Natl Inst Hyg, Warsaw, Poland..
    Wong, Tien Yin
    Duke NUS Grad Med Sch, Singapore, Singapore..
    Woo, Jean
    Chinese Univ Hong Kong, Hong Kong, Hong Kong, Peoples R China..
    Woodward, Mark
    Univ Sydney, Sydney, NSW 2006, Australia.;Univ Oxford, Oxford, England..
    Wu, Frederick C.
    Univ Manchester, Manchester, Lancs, England..
    Wu, Shou Ling
    Kailuan Gen Hosp, Tangshan, Peoples R China..
    Xu, Haiquan
    Minist Agr, Inst Food & Nutr Dev, Beijing, Peoples R China..
    Yan, Weili
    Fudan Univ, Shanghai, Peoples R China..
    Yang, Xiaoguang
    Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China..
    Ye, Xingwang
    Univ Chinese Acad Sci, Beijing, Peoples R China..
    Yoshihara, Akihiro
    Niigata Univ, Niigata 95021, Japan..
    Younger-Coleman, Novie O.
    Univ W Indies, Kingston, Jamaica..
    Zambon, Sabina
    Univ Padua, Padua, Italy..
    Zargar, Abdul Hamid
    Ctr Diabet & Endocrine Care, New Delhi, India..
    Zdrojewski, Tomasz
    Med Univ Gdansk, Gdansk, Poland..
    Zhao, Wenhua
    Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China..
    Zheng, Yingfeng
    Singapore Eye Res Inst, Singapore, Singapore..
    Zuniga Cisneros, Julio
    Gorgas Mem Inst Publ Hlth, Panama City, Panama..
    Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4.4 million participants2016In: The Lancet, ISSN 0140-6736, E-ISSN 1474-547X, Vol. 387, no 10027, p. 1513-1530Article in journal (Refereed)
    Abstract [en]

    Background One of the global targets for non-communicable diseases is to halt, by 2025, the rise in the age-standardised adult prevalence of diabetes at its 2010 levels. We aimed to estimate worldwide trends in diabetes, how likely it is for countries to achieve the global target, and how changes in prevalence, together with population growth and ageing, are affecting the number of adults with diabetes. Methods We pooled data from population-based studies that had collected data on diabetes through measurement of its biomarkers. We used a Bayesian hierarchical model to estimate trends in diabetes prevalence-defined as fasting plasma glucose of 7.0 mmol/L or higher, or history of diagnosis with diabetes, or use of insulin or oral hypoglycaemic drugs-in 200 countries and territories in 21 regions, by sex and from 1980 to 2014. We also calculated the posterior probability of meeting the global diabetes target if post-2000 trends continue. Findings We used data from 751 studies including 4 372 000 adults from 146 of the 200 countries we make estimates for. Global age-standardised diabetes prevalence increased from 4.3% (95% credible interval 2.4-7.0) in 1980 to 9.0% (7.2-11.1) in 2014 in men, and from 5.0% (2.9-7.9) to 7.9% (6.4-9.7) in women. The number of adults with diabetes in the world increased from 108 million in 1980 to 422 million in 2014 (28.5% due to the rise in prevalence, 39.7% due to population growth and ageing, and 31.8% due to interaction of these two factors). Age-standardised adult diabetes prevalence in 2014 was lowest in northwestern Europe, and highest in Polynesia and Micronesia, at nearly 25%, followed by Melanesia and the Middle East and north Africa. Between 1980 and 2014 there was little change in age-standardised diabetes prevalence in adult women in continental western Europe, although crude prevalence rose because of ageing of the population. By contrast, age-standardised adult prevalence rose by 15 percentage points in men and women in Polynesia and Micronesia. In 2014, American Samoa had the highest national prevalence of diabetes (>30% in both sexes), with age-standardised adult prevalence also higher than 25% in some other islands in Polynesia and Micronesia. If post-2000 trends continue, the probability of meeting the global target of halting the rise in the prevalence of diabetes by 2025 at the 2010 level worldwide is lower than 1% for men and is 1% for women. Only nine countries for men and 29 countries for women, mostly in western Europe, have a 50% or higher probability of meeting the global target. Interpretation Since 1980, age-standardised diabetes prevalence in adults has increased, or at best remained unchanged, in every country. Together with population growth and ageing, this rise has led to a near quadrupling of the number of adults with diabetes worldwide. The burden of diabetes, both in terms of prevalence and number of adults affected, has increased faster in low-income and middle-income countries than in high-income countries. Funding Wellcome Trust.

  • 973. Zimmermann, Stefan
    et al.
    Flachskampf, Frank A
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    Alff, Anna
    Schneider, Reinhard
    Dechant, Katharina
    Klinghammer, Lutz
    Stumpf, Christian
    Zopf, Yurdaguel
    Loehr, Thomas
    Brand, Georg
    Ludwig, Josef
    Daniel, Werner G
    Achenbach, Stephan
    Out-of-hospital cardiac arrest and percutaneous coronary intervention for ST-elevation myocardial infarction: Long-term survival and neurological outcome2013In: International Journal of Cardiology, ISSN 0167-5273, E-ISSN 1874-1754, Vol. 166, no 1, p. 236-241Article in journal (Refereed)
    Abstract [en]

    BACKGROUND:

    Predictors of long-term outcome after ST-elevation myocardial infarction (STEMI) complicated by out-of-hospital cardiac arrest (OHCA) are incompletely understood, including the influence of successful coronary reperfusion.

    METHODS:

    We analysed clinical and procedural data as well as 1-year outcome of 72 consecutive patients who underwent primary coronary intervention (PCI) after witnessed OHCA and STEMI and compared the results with 695 patients with STEMI and PCI, but without OHCA. Neurological recovery after OHCA was assessed using the Cerebral Performance Category (CPC) scale.

    RESULTS:

    PCI was successful in 83.3% after OHCA vs. 84.3% in the non-OHCA group (p=0.87). One-year mortality was 34.7% vs. 9.5% (p<0.001). 58.3% of the OHCA-patients showed complete neurological recovery (CPC 1) or moderate neurological disability (CPC 2). Another 6.9% showed severe cerebral disability (CPC 3) or permanent vegetative status (CPC 4). Delay from collapse until start of Advanced Cardiopulmonary Life Support (ACLS) was shorter for survivors with CPC status ≤2 (median 1min, range 0-11min) compared to non-survivors or survivors with CPC status >2 (median 8min, range 0-13min), p<0.0001. Age-adjusted multivariate analysis identified 'unsuccessful PCI', 'vasopressors on admission' and 'start of ACLS after >6min' as independent predictors of negative long-term outcome (death or CPC >2).

    CONCLUSIONS:

    Mortality is high in patients with STEMI complicated by OHCA - even though PCI was performed with the same success rate as in patients without OHCA. The majority of survivors had favourable neurological outcomes at 1year, especially if advanced life support had been started within ≤6min and PCI was successful.

  • 974. Zimmermann, Stefan
    et al.
    Flachskampf, Frank A.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    Schneider, Reinhard
    Dechant, Katharina
    Alff, Anna
    Klinghammer, Lutz
    Rittger, Harald
    Achenbach, Stephan
    Mild Therapeutic Hypothermia After Out-Of-Hospital Cardiac Arrest Complicating ST-Elevation Myocardial Infarction: Long-term Results in Clinical Practice2013In: Clinical Cardiology, ISSN 0160-9289, E-ISSN 1932-8737, Vol. 36, no 7, p. 414-421Article in journal (Refereed)
    Abstract [en]

    BackgroundRecently, mild therapeutic hypothermia (MTH) has been integrated into the European resuscitation guidelines to improve outcomes after out-of-hospital cardiac arrest (OHCA). Data on long-term results are limited, especially in patients with acute ST-elevation myocardial infarction (STEMI). HypothesisInvasive MTH influences long-term prognosis after OHCA due to STEMI. MethodsWe analyzed 48 patients who underwent emergency coronary angiography for STEMI after witnessed OHCA. In 24 consecutive patients, MTH was performed via intravascular cooling (CoolGard System, 34 degrees C maintained for 24 hours) after initialization by rapid infusion of cold saline. Clinical, procedural, and mortality data were compared to 24 historical controls. Neurological recovery was assessed using the Cerebral Performance Category score (CPC) at 30-day and 1-year follow-up. ResultsMedian time delay until arrival of emergency medical service was 6 minutes (MTH group) vs 6.5 minutes (controls) (P=0.16). Initial rhythm was ventricular fibrillation in 75% vs 66.7% (P=0.75). There were no differences regarding baseline characteristics, angiographic findings, and success of cardiac catheterization procedures. MTH was not associated with a higher frequency of bleeding complications or of pneumonia. Thirty-day mortality was 33.3% in both groups. One-year mortality was 37.5% (MTH group) vs 50% (controls) (P=0.56). At 1 year, favorable neurological outcome (CPC 2) was significantly more frequent in the MTH group (58.3% vs 20.8%, P=0.017). Multivariate analysis identified MTH as independent predictor of favorable neurological outcome (P<0.02, odds ratio: 12.73). ConclusionsMTH via intravascular cooling improves neurological long-term prognosis after OHCA due to STEMI and is safe in clinical practice.

  • 975. Zucchelli, Giulio
    et al.
    Di Cori, Andrea
    Segreti, Luca
    Laroche, Cécile
    Blomström-Lundqvist, Carina
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology-Arrhythmia. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    Kutarski, Andrzej
    Regoli, François
    Butter, Christian
    Defaye, Pascal
    Pasquié, Jean Luc
    Auricchio, Angelo
    Maggioni, Aldo P
    Bongiorni, Maria Grazia
    Major cardiac and vascular complications after transvenous lead extraction: acute outcome and predictive factors from the ESC-EHRA ELECTRa (European Lead Extraction ConTRolled) registry.2019In: Europace, ISSN 1099-5129, E-ISSN 1532-2092, Vol. 21, no 5, p. 771-780Article in journal (Refereed)
    Abstract [en]

    Aims: We aimed at describing outcomes and predictors of cardiac avulsion or tear (CA/T) with tamponade and vascular avulsion or tear (VA/T) after transvenous lead extraction (TLE) in the ESC-EHRA European Lead Extraction ConTRolled (ELECTRa) registry.

    Methods and results: A total of 3555 consecutive patients of whom 3510 underwent TLE at 73 centres in 19 European countries were enrolled. Among 58 patients (1.7%) with procedure-related major complications, 49 (84.5%) patients (30 CA/T and 19 VA/T) presented cardiovascular complications requiring pericardiocentesis, chest tube positioning and/or surgical repair. The mortality was 20% in patients with tamponade due to CA/T and 31.6% in patients with VA/T. Pericardiocentesis as first manoeuvre followed by rescue surgical repair was highly effective in case of CA/T (93.8%). At multivariate analysis, CA/T with tamponade was more common in RIATA lead extraction, female patients, leads with a mean dwelling time more than 10 years, and when ≥3 leads were extracted or multiple sheaths required. Occlusion or critical stenosis of superior venous access and the leads mean dwelling time more than 10 years were independent predictors for VA/T, while mechanical dilatation was an independent predictor of a lower incidence of this complication as compared to the use of powered sheaths.

    Conclusions: In the ELECTRa registry, RIATA lead extraction and superior venous access occlusion/thrombosis are two new independent predictors for cardiac tamponade and major vascular complications, respectively. The use of mechanical sheaths seems to be associated with a lower incidence of VA/T. A strategy of pericardiocentesis followed by a rescue surgical approach seems to be reasonable in order to treat a CA/T with tamponade.

  • 976.
    Åkerblom, Axel
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    Biomarkers of Renal Function in Acute Coronary Syndromes2013Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The thesis aimed to investigate cystatin C and creatinine-based estimates of glomerular filtration rate (eGFR), both at admission and during follow-up, on the combined endpoint of cardiovascular death and myocardial infarction in patients with acute coronary syndrome (ACS). We also evaluated two cystatin C assays and assessed genetic determinants of cystatin C concentrations.

    We used the PLATelet inhibition and Patient Outcomes study, where all types of ACS patients (n=18624) were randomized to ticagrelor or clopidogrel treatment. Multivariable Cox regression models, including clinical variables and biomarkers (troponin and NT-proBNP), and c-statistics were calculated.

    Cystatin C and the creatinine-based CKD-EPI equation exhibited similar significant prognostic impact on the combined endpoint, with Area Under Curves (AUC) 0.6923 and 0.6941, respectively. Follow-up samples of renal biomarkers did not improve risk prediction.

    Patients randomized to ticagrelor treatment were associated with a non-sustained larger increase in renal markers at discharge, but neither the change nor the difference between the randomized groups affected cardiovascular risk.

    Two different cystatin C assays exhibited good correlation 0.86 (95% confidence interval 0.85-0.86), however moderate level of agreement. Risk prediction with a combination of creatinine and cystatin C did not outperform the creatinine-based CKD-EPI equation, AUC: 0.6913 and 0.6924, respectively (n=13050).

    The genetic polymorphism rs6048952 independently affected the cystatin C concentration with mean levels of 0.85mg/L, 0.80mg/L and 0.73mg/L for the A/A, A/G, and G/G genotypes, respectively.

    The genetic polymorphism did not affect outcome overall, however in the non-ST-elevation ACS subgroup a signal that genetic polymorphism may be associated with cardiovascular death was observed (p=0.002).

    In conclusion: cystatin C or eGFR, irrespective of equation or assay, are important cardiovascular risk factors in ACS patients. Nonetheless, the incremental value of adding any renal variable, to a multivariable risk model, is small. Further research on the impact of cystatin C genetic polymorphism is warranted.

  • 977.
    Åkerblom, Axel
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center. Duke Clin Res Inst, Durham, NC USA..
    Clare, Robert M.
    Duke Clin Res Inst, Durham, NC USA..
    Lokhnygina, Yuliya
    Duke Clin Res Inst, Durham, NC USA..
    Wallentin, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    Held, Claes
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
    Van de Werf, Frans
    Univ Leuven, Dept Cardiol, Leuven, Sweden..
    Moliterno, David J.
    Univ Kentucky, Gill Heart Inst, Lexington, KY USA.;Univ Kentucky, Div Cardiovasc Med, Lexington, KY USA..
    Patel, Uptal D.
    Duke Clin Res Inst, Durham, NC USA..
    Leonardi, Sergio
    Fdn IRCCS Policlin San Matteo, Pavia, Italy..
    Armstrong, Paul W.
    Univ Alberta, Div Cardiol, Edmonton, AB, Canada..
    Harrington, Robert A.
    Stanford Univ, Dept Med, Stanford, CA 94305 USA..
    White, Harvey D.
    Auckland City Hosp, Green Lane Cardiovasc Serv, Auckland, New Zealand..
    Aylward, Philip E.
    Flinders Univ & Med Ctr, South Australian Hlth & Med Res Inst, Adelaide, SA, Australia..
    Mahaffey, Kenneth W.
    Stanford Univ, Dept Med, Stanford, CA 94305 USA..
    Tricoci, Pierluigi
    Duke Clin Res Inst, Durham, NC USA..
    Albuminuria and cardiovascular events in patients with acute coronary syndromes: Results from the TRACER trial2016In: American Heart Journal, ISSN 0002-8703, E-ISSN 1097-6744, Vol. 178, p. 1-8Article in journal (Refereed)
    Abstract [en]

    Background Albuminuria is associated with cardiovascular (CV) outcomes. We evaluated albuminuria, alone and in combination with estimated glomerular filtration rate (eGFR), as a predictor of mortality and CV morbidity in 12,944 patients with non-ST-segment elevation acute coronary syndromes. Methods Baseline serum creatinine and urinary dipsticks were obtained, with albuminuria stratified into no/trace albuminuria, microalbuminuria (>= 30 but <300 mg/dL), or macroalbuminuria (>= 300 mg/dL). Kaplan-Meier rates and proportional Cox hazards models of CV death, overall mortality, CV death or myocardial infarction (MI), and bleeding were calculated. Incidence of acute kidney injury, identified by adverse event reporting and creatinine increase (absolute >= 0.3 mg/dL or relative >= 50%), was descriptively reported. Results Both dipstick albuminuria and creatinine values were available in 9473 patients (73.2%). More patients with macroalbuminuria, versus no/trace albuminuria, had diabetes (66% vs 27%) or hypertension (86% vs 68%). Rates for CV death and overall mortality per strata were 3.1% and 4.8% (no/trace albuminuria); 5.8% and 9.0% (microalbuminuria); and 7.7% and 12.6% (macroalbuminuria) at 2 years of follow-up. Corresponding rates for CV death or MI were 12.2%, 16.9%, and 23.5%, respectively. Observed acute kidney injury rates were 0.6%, 1.2%, and 2.9% (n = 79), respectively. Adjusted HRs for macroalbuminuria on CV mortality were 1.65 (95% CI 1.15-2.37), and after adjustment with eGFR, 1.37 (95% CI 0.93-2.01). Corresponding HRs for overall mortality were 1.82 (95% CI 1.37-2.42) and 1.47 (95% CI 1.08-1.98). Conclusions High-risk patients with non-ST-segment elevation acute coronary syndromes and albuminuria have increased morbidity and increased overall mortality independent of eGFR.

  • 978.
    Åkerblom, Axel
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
    Eriksson, Niclas
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
    Wallentin, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
    Siegbahn, Agneta
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Coagulation and inflammation science. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
    Becker, Richard C.
    Duke Clinical Research Institute, Durham, NC, USA.
    Budaj, Andrzej
    Postgraduate Medical School, Grochowski Hospital, Warsaw, Poland.
    Himmelmann, Anders
    AstraZeneca Research and Development, Mölndal, Sweden.
    Husted, Steen
    Department of Cardiology, Århus University Hospital, Århus, Denmark.
    Storey, Robert F.
    Department of Cardiovascular Science, University of Sheffield, Sheffield, UK.
    Johansson, Åsa
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
    James, Stefan K.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
    Polymorphism of the cystatin C gene in patients with acute coronary syndromes: Results from the PLATelet Inhibition and Patient Outcomes (PLATO) Study2014In: American Heart Journal, ISSN 0002-8703, E-ISSN 1097-6744, Vol. 168, no 1, p. 96-102Article in journal (Other academic)
    Abstract [en]

    Purpose: Plasma cystatin C is independently associated with cardiovascular (CV) risk in non-ST-elevation acute coronary syndromes (NSTE-ACS). The effect of genetic variability on cystatin C concentrations and outcome is unclear.

    Methods: Plasma cystatin C concentrations were measured in blood, obtained within 24 hours of admission, in 16279 ACS patients from the PLATelet inhibition and patient Outcomes trial. 9978 patients were genome-wide genotyped with up to 2.5 million SNPs. The first occurrence of CV death or myocardial infarction (MI) within one year was evaluated by multivariable (clinical variables and biomarkers) Cox regression analysis and c-statistics both overall (all ACS) and in NSTE-ACS.

    Results: We observed SNPs association with cystatin C levels (up to p=7.82 x 10-16). The most significant SNP (rs6048952) was adjacent the CST3 gene with additive effect on cystatin C concentrations: 0.85mg/L, 0.80mg/L and 0.73mg/L for the A/A, A/G and G/G genotypes respectively. Multivariable c-statistics regarding the combined endpoint (CV death or MI) was 0.6619. Adding cystatin C concentrations or genetically adjusted cystatin C levels, exhibited c-statistics of 0.6705 and 0.6703, respectively.

    The overall hazard ratio for rs6048952 was 0.93 (95%CI 0.82-1.04) regarding the CV death or MI while 0.85 (95%CI 0.70-1.03) regarding CV death in all ACS patients. In the NSTE-ACS subgroup, the hazard ratio for rs6048952 was 0.72 (95%CI 0.54-0.95).

    Conclusions: Genetic polymorphism, independently of kidney function, affects cystatin C concentrations, but does not appear to influence ischemic outcome in an overall ACS population. However, genetic variation appears to affect cardiovascular mortality in moderate-to-high risk NSTE-ACS patients.

  • 979.
    Åkerblom, Axel
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
    Helmersson, Johanna
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
    Weitoft, Tomas
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Research and Development, Gävleborg.
    Larsson, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
    Seasonal variations of urate in a Swedish adult population2017In: Clinical Rheumatology, ISSN 0770-3198, E-ISSN 1434-9949, Vol. 36, no 7, p. 1595-1598Article in journal (Refereed)
    Abstract [en]

    Seasonality in the incidence and prevalence of gout has previously been reported but the cause of this seasonality in gout is not explained. The aim of this study was to evaluate possible seasonal variations of urate in a large unselected Swedish adult population. We analyzed 170,915 urate test results from patients at a tertiary care hospital between 2000 and 2016. The results were divided according to sex and sampling month of the year. The median urate values were overall higher in males compared to females and both males and females had peak urate concentrations in the summer months (June-August). There is a seasonal pattern for urate concentrations in a large Swedish population similar to the previously reported seasonality for gout. This may be clinically important and could contribute to the circannual variation of gout. The seasonal pattern should be recognized when evaluating patient results both in clinical practice and in research studies.

  • 980.
    Åkerblom, Axel
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
    James, Stefan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
    Bertilsson, Maria
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
    Himmelmann, Anders
    Huhn, Monika
    Pieper, Karen
    Husted, Steen
    Storey, Robert
    Becker, Richard
    Wallentin, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    Serum Uric Acid Is Associated With Cardiovascular Outcomes In Patients With Acute Coronary Syndromes: Results From The Platelet Inhibition And Patient Outcomes (Plato) Trial2016In: Journal of the American College of Cardiology, ISSN 0735-1097, E-ISSN 1558-3597, Vol. 67, no 13, p. 556-556Article in journal (Other academic)
  • 981.
    Åkerblom, Axel
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    Oldgren, Jonas
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
    Latva-Rasku, Aino
    Univ Turku, Turku PET Ctr, Turku, Finland;Turku Univ Hosp, Dept Endocrinol, Turku, Finland.
    Johansson, Lars
    Antaros Med AB, Gothenburg, Sweden.
    Lisovskaja, Vera
    AstraZeneca, Gothenburg, Sweden.
    Karlsson, Cecilia
    AstraZeneca, Gothenburg, Sweden.
    Oscarsson, Jan
    AstraZeneca, Gothenburg, Sweden.
    Nuutila, Pirjo
    Univ Turku, Turku PET Ctr, Turku, Finland;Turku Univ Hosp, Dept Endocrinol, Turku, Finland.
    Effects of DAPAgliflozin on CARDiac substrate uptake, myocardial efficiency, and myocardial contractile work in type 2 diabetes patients - a description of the DAPACARD study2019In: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 124, no 1, p. 59-64Article in journal (Refereed)
    Abstract [en]

    Background: Diabetes increases the risk for cardiovascular (CV) events. It has recently been shown that the use of sodium-glucose cotransporter 2 (SGLT2) inhibitors leads to a reduction in CV outcomes in patients with type 2 diabetes mellitus (T2DM), including mortality and heart failure hospitalization. The exact mechanisms of how SGLT2 inhibitors lead to this CV risk reduction remain incompletely understood. The study of DAPAgliflozin on CARDiac substrate uptake, myocardial efficiency and myocardial contractile work in type 2 diabetes patients (DAPACARD) (NCT03387683) explores the possible effects of dapagliflozin, an SGLT2 inhibitor, on cardiac work, metabolism, and biomarker levels.

    Methods: DAPACARD is an international, randomized, double-blind trial that aims to examine the effects of dapagliflozin versus matching placebo in 52 patients with T2DM that are on stable metformin therapy prior to and during the 6 weeks of treatment. The primary efficacy endpoint is change in global longitudinal strain of the left ventricle (GLSLV) measured with magnetic resonance imaging (MRI) between baseline (pre-treatment) and end of study (on-treatment). The secondary endpoint is the corresponding change in myocardial efficiency measured as external left ventricular work divided by total left ventricular work, which is estimated using [11C]-acetate clearance using positron emission tomography (PET).

    Conclusion: The DAPACARD study is an extensive investigation of cardiac function and metabolism, by advanced imaging with PET and MRI, as well as biomarkers, performed in order to further explore how the SGLT2 inhibitor dapagliflozin could influence cardiovascular outcomes in patients with T2DM.

  • 982.
    Åkerblom, Axel
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
    Wallentin, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
    Larsson, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry.
    Siegbahn, Agneta
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Coagulation and inflammation science.
    Becker, Richard C.
    Duke Clinical Research Institute, Durham, NC, USA.
    Budaj, Andrzej
    Postgraduate Medical School, Grochowski Hospital, Warsaw, Poland.
    Himmelmann, Anders
    AstraZeneca Research and Development, Mölndal, Sweden.
    Horrow, Jay
    AstraZeneca Research and Development, Wilmington, USA.
    Husted, Steen
    Department of Cardiology, Århus University Hospital, Århus, Denmark.
    Storey, Robert F.
    Department of Cardiovascular Science, University of Sheffield, Sheffield, UK.
    Åsenblad, Nils
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
    James, Stefan K.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
    Cystatin C- and Creatinine-based Estimates of Renal Function and Their Value for Risk Prediction in Patients with Acute Coronary Syndrome: Results from the PLATelet Inhibition and Patient Outcomes (PLATO) Study2013In: Clinical Chemistry, ISSN 0009-9147, E-ISSN 1530-8561, Vol. 59, no 9, p. 1369-1375Article in journal (Refereed)
    Abstract [en]

    Background: The estimated glomerular filtration rate (eGFR) independently predicts cardiovascular (CV) death or myocardial infarction (MI), and can be estimated by creatinine and cystatin C concentrations. We evaluated two different cystatin C assays, alone or combined with creatinine, in patients with acute coronary syndromes.

    Methods: Plasma cystatin C, measured with assays from Gentian and Roche, and serum creatinine was analyzed in 16279 patients from the PLATelet inhibition and patient Outcomes trial. Pearson’s correlation and agreement (Bland–Altman) between methods was evaluated. Prognostic value in relation to CV death or MI during one year of follow up was evaluated by multivariable logistic regression analysis including clinical variables and biomarkers, c-statistics and relative Integrated Discrimination Improvement (IDI).

    Results: Median cystatin C concentrations (interquartile intervals) were 0.83 (0.68 - 1.01) mg/L (Gentian) and 0.94 (0.80 - 1.14) mg/L (Roche). Overall correlation was 0.86 (95% confidence interval 0.85-0.86). The level of agreement was ±0.39mg/L (±2 standard deviations) (n=16279).

    The area under curve (AUC) in the multivariable risk prediction model with cystatin C (Gentian, Roche) or Chronic Kidney Disease - Epidemiology (CKD-EPI) added was 0.6914, 0.6913 and 0.6932. Corresponding relative IDIs were 2.96%, 3.86% and 4.68%, respectively (n=13050). Addition of eGFR by the combined creatinine-cystatin C equation yielded AUC of 0.6923(Gentian) and 0.6924(Roche) with relative IDIs of 3.54% and 3.24% respectively.

    Conclusions: Despite differences in cystatin C concentrations, overall correlation between the Gentian and Roche assays was good while agreement was moderate.  The combined creatinine-cystatin C equation did not outperform risk prediction compared to CKD-EPI.

  • 983.
    Åkerblom, Axel
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    Wallentin, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    Siegbahn, Agneta
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Coagulation and inflammation science.
    Becker, R. C.
    Budaj, A.
    Horrow, J.
    Husted, S.
    Katus, H.
    Claeys, M. J.
    Storey, R. F.
    Åsenblad, Nils
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
    James, Stefan K.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    Outcome and causes of renal deterioration evaluated by serial cystatin C measurements in acute coronary syndrome patients: Results from the PLATelet inhibition and patient Outcomes (PLATO) study2012In: American Heart Journal, ISSN 0002-8703, E-ISSN 1097-6744, Vol. 164, no 5, p. 728-734Article in journal (Refereed)
    Abstract [en]

    Background: To investigate if ticagrelor treatment and other clinical characteristics were associated with increased cystatin C concentrations and if a deterioration in estimated renal function was associated with worse outcome in patients with acute coronary syndromes (ACS). Methods: Plasma cystatin C concentrations were determined within 24 hours of admission (baseline), at discharge, 1 month, and 6 months in the PLATO trial. The changes over time in relation to randomized treatment were analyzed by analysis of covariance. C-statistics and the relative Integrated Discrimination Improvement of the cystatin C concentrations regarding the primary outcome (cardiovascular death or myocardial infarction) was evaluated by multivariable analysis including background characteristics and biomarkers: N-terminal-pro-B-type natriuretic peptide and Troponin I. Results: Mean cystatin C concentrations in 2133 ticagrelor- and 2162 clopidogrel-treated patients were at baseline (0.86 mg/L and 0.86 mg/L), discharge (1.01 mg/L and 0.98 mg/L) (P <.0005), 1 month (1.00 mg/L and 0.98 mg/L) (P =.12), and 6 months (1.00 mg/L and 0.99 mg/L) (P =.17), respectively. Age, heart failure, and type of ACS were major determinants of the cystatin C concentration. c Statistics and the relative Integrated Discrimination Improvement of the primary outcome for the baseline cystatin C concentration were 0.687 and 5.2%, compared to 0.684 and 4.5% at discharge (n = 4034) and 0.693 and 5.1% at one month (n = 3096), respectively. Conclusions: Mean cystatin C concentrations increased in ACS patients, most importantly determined by age. The initial greater increase in ticagrelor-treated patients was not sustained over time. Risk prediction did not improve with serial measurements of renal markers.

  • 984.
    Åkerblom, Axel
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
    Wallentin, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    Siegbahn, Agneta
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Coagulation and inflammation science.
    Becker, R. C.
    Budaj, A.
    Katus, H.
    Claeys, M. J.
    Storey, R. F.
    Åsenblad, Nils Gunnar
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
    James, Stefan K.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    Serial cystatin C measurements and changes in glomerular filtration rate as predictors for death or myocardial infarction in ACS patients2012In: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 33, no Suppl 1, p. 135-135Article in journal (Other academic)
  • 985.
    Åkerblom, Axel
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    Wallentin, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    Siegbahn, Agneta
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Coagulation and inflammation science.
    Becker, Richard C.
    Budaj, Andrzej
    Himmelmann, Anders
    Husted, Steen
    Storey, Robert F.
    Eriksson, Niclas
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
    Johansson, Åsa
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
    James, Stefan K.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
    Genetic Polymorphism and Relationship to Cystatin C Concentrations and Outcome - Results From the Platelet Inhibition and Patient Outcomes Study2013In: Circulation, ISSN 0009-7322, E-ISSN 1524-4539, Vol. 128, no 22Article in journal (Other academic)
  • 986.
    Åsberg, Signild
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology. Riksstroke, Västerbotten County Council, Umeå, Sweden.
    Hijazi, Ziad
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
    Norrving, Bo
    Riksstroke, Västerbotten County Council, Umeå, Sweden.; Department of Neurology, Lund University, Lund, Sweden.
    Terént, Andreas
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology. Riksstroke, Västerbotten County Council, Umeå, Sweden.
    Öhagen, Patrik
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
    Oldgren, Jonas
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    Timing of oral anticoagulant therapy in acute ischemic stroke with atrial fibrillation: study protocol for a registry-based randomised controlled trial2017In: Trials, ISSN 1745-6215, E-ISSN 1745-6215, Vol. 18, no 1, article id 581Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Oral anticoagulation therapy is recommended for the prevention of recurrent ischemic stroke in patients with atrial fibrillation (AF). Current guidelines do not provide evidence-based recommendations on optimal time-point to start anticoagulation therapy after an acute ischemic stroke. Non-vitamin K antagonist oral anticoagulants (NOACs) may offer advantages compared to warfarin because of faster and more predictable onset of action and potentially a lower risk of intracerebral haemorrhage also in the acute phase after an ischemic stroke. The TIMING study aims to establish the efficacy and safety of early vs delayed initiation of NOACs in patients with acute ischemic stroke and AF.

    METHODS/DESIGN: The TIMING study is a national, investigator-led, registry-based, multicentre, open-label, randomised controlled study. The Swedish Stroke Register is used for enrolment, randomisation and follow-up of 3000 patients, who are randomised (1:1) within 72 h from ischemic stroke onset to either early (≤ 4 days) or delayed (≥ 5-10 days) start of NOAC therapy. The primary outcome is the composite of recurrent ischemic stroke, symptomatic intracerebral haemorrhage, or all-cause mortality within 90 days after randomisation. Secondary outcomes include: individual components of the primary outcome at 90 and 365 days; major haemorrhagic events; functional outcome by the modified Rankin Scale at 90 days; and health economics. In an optional biomarker sub-study, blood samples will be collected after randomisation from approximately half of the patients for central analysis of cardiovascular biomarkers after study completion. The study is funded by the Swedish Medical Research Council. Enrolment of patients started in April 2017.

    CONCLUSION: The TIMING study addresses the ongoing clinical dilemma of when to start NOAC after an acute ischemic stroke in patients with AF. By the inclusion of a randomisation module within the Swedish Stroke Register, the advantages of a prospective randomised study design are combined with the strengths of a national clinical quality register in allowing simplified enrolment and follow-up of study patients. In addition, the register adds the possibility of directly assessing the external validity of the study findings.

    TRIAL REGISTRATION: ClinicalTrials.gov, NCT02961348 . Registered on 8 November 2016.

17181920 951 - 986 of 986
CiteExportLink to result list
Permanent link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf