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  • 51.
    Larsby, Birgitta
    et al.
    Linköping University.
    Ödkvist, Lars
    Östergötlands Läns Landsting.
    Hydén, Dag
    Linköping University.
    Liedgren, Christer
    Östergötlands Läns Landsting.
    Disturbances of the vestibular system by toxic agents1976In: 15. Scandinavian Congress of Physiology and Pharmacology, Århus 1976: Abstracts of Invited Lectures, Symposia and Free Communications, Fysiologisk Institut, Aarhus Universitet , 1976, p. 157-157Conference paper (Other academic)
  • 52.
    Larsby, Birgitta
    et al.
    Linköping University.
    Ödkvist, Lars
    Linköping University.
    Hydén, Dag
    Linköping University.
    Tham, Richard
    Linköping University.
    Rubin, Allan
    University of Toronto, Canada.
    Aschan, Gunnar
    Linköping University.
    Industriella lösningsmedels inverkan på balansapparaten1977In: Svensk Otolaryngol förening, ISSN 0280-7939, Vol. 1, p. 43-44Article in journal (Other academic)
  • 53.
    Liedgren, Christer
    et al.
    Östergötlands Läns Landsting.
    Kristensson, Krister
    Östergötlands Läns Landsting.
    Larsby, Birgitta
    Östergötlands Läns Landsting.
    Ödkvist, Lars
    Östergötlands Läns Landsting.
    Projection of thalamic neurons to cat primary vestibular cortical fields studied by means of retrograde axonal transport of horseradish peroxidase1976In: Experimental Brain Research, ISSN 0014-4819, E-ISSN 1432-1106, Vol. 24, no 3, p. 237-243Article in journal (Refereed)
    Abstract [en]

    The two vestibular cortical projection areas in the anterior suprasylvian sulcus and post-cruciate dimple regions were defined by evoked potential technique in anaesthetized cats. The thalamic location of neurons with axon terminals in these fields was determined using the method of retrograde axonal transport of horseradish peroxidase. The ascending vestibular pathway appeared to be separated also at the thalamic level, where cells in the ventro-posterolateral nucleus were found to project to the post cruciate dimple and cells in the posterior nuclear group to the anterior suprasylvian vestibular cortical fields.

  • 54.
    Liedgren, Christer
    et al.
    Östergötlands Läns Landsting.
    Rubin, Allan
    University of Toronto, Canada.
    Aschan, Gunnar
    Linköping University.
    Ödkvist, Lars
    Linköping University.
    Larsby, Birgitta
    Linköping University.
    Influence of neck afferents on activity in the cat vestibular nuclei1978In: Vestibular mechanisms in health and disease, 1978 / [ed] Hood, J D, Academic Press, 1978, p. 18-27Conference paper (Other academic)
  • 55.
    Möller, Claes
    et al.
    Linköping University.
    Ödkvist, Lars
    Linköping University.
    Larsby, Birgitta
    Linköping University.
    Tham, Richard
    Linköping University.
    Ledin, Torbjörn
    Linköping University.
    Bergholtz, Lars
    Östergötlands Läns Landsting.
    Otoneurological findings in workers exposed to styrene1990In: Scandinavian Journal of Work, Environment and Health, ISSN 0355-3140, E-ISSN 1795-990X, Vol. 16, no 3, p. 189-194Article in journal (Refereed)
    Abstract [en]

    An otoneurological test battery was administered to 18 workers with long-term exposure (6-15 years) to styrene at levels well below the current Swedish limit (110 mg/m3). The results were compared with those of a reference group. Disturbances were found in the central auditory pathways of seven workers. Tests reflecting central processing of impulses from different sensory equilibrium organs were abnormal for 16 workers. The most relevant tests seemed to be static posturography and the rotatory visual suppression test. In the posturography the styrene group had a significantly larger sway area than the reference group. In the visual suppression test, the styrene workers displayed a significantly poorer ability to suppress vestibular nystagmus than the reference group. It was concluded that styrene exposure in industrial environments at moderate or low levels causes central nervous system disturbances which are not always diagnosable with psychometric tests but can be apparent in special otoneurological tests.

  • 56.
    Möller, Claes
    et al.
    Linköping University.
    Ödkvist, Lars
    Östergötlands Läns Landsting.
    Larsby, Birgitta
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    Tham, Richard
    Linköping University.
    Ledin, Torbjörn
    Linköping University.
    Bergholtz, Lars
    Östergötlands Läns Landsting.
    Otoneurologiska fynd hos styren-exponerade arbetare1990In: Sv Otolaryngol förening Vårmöte 1990, 1990Conference paper (Other academic)
  • 57.
    Möller, Claes
    et al.
    Department of Otolaryngology, University Hospital, Linkoping, Sweden.
    Ödkvist, Lars
    Linköping University.
    Thell, Jan
    Östergötlands Läns Landsting.
    Larsby, Birgitta
    Linköping University.
    Hydén, Dag
    Linköping University.
    Vestibular and audiologic functions in Gentamicin-treated Menier's disease1988In: The American journal of otology, ISSN 0192-9763, Vol. 9, no 5, p. 383-391Article in journal (Refereed)
    Abstract [en]

    Fifteen patients with disabling Meniere's disease were treated with local intratym-panic administration of gentamicin once daily. They had suffered from frequent attacks of vertigo and vomiting, the hearing in the affected ears was decreased permanently, and spontaneous nystagmus was observed. The number of treatment days ranged between 3 and 11. Follow-up time was 1 to 6 years. For evaluation of the treatment, audiologic and vestibular examinations were used, including the broad frequency-band rotatory test (0.4-4.5 Hz). Fourteen patients were free from vertigo after treatment. In 5 patients, there was an increased hearing loss, and in 10 it remained unchanged. Tinnitus and fullness sensations were diminished. After treatment, all ears were unresponsive to caloric stimulation. The clinical examination and rotatory testing in light with sinusoidal stimulation revealed good central compensation of the vestibular loss. However, with pseudorandomized oscillations in darkness, the broad frequency-band rotatory test quantified the loss of peripheral vestibular function and was able to detect the side of the lesion in eight of nine patients.

  • 58.
    Möller, Claes
    et al.
    Östergötlands Läns Landsting. Department of Otolaryngology and Head and Neck Surgery, University Hospital, Linköping, Sweden.
    Ödkvist, Lars
    Linköping University. Department of Otolaryngology and Head and Neck Surgery, University Hospital, Linköping, Sweden.
    Thell, Jan
    Östergötlands Läns Landsting. Department of Otolaryngology and Head and Neck Surgery, University Hospital, Linköping, Sweden.
    Larsby, Birgitta
    Linköping University. Department of Otolaryngology and Head and Neck Surgery, University Hospital, Linköping, Sweden.
    Hydén, Dag
    Linköping University. Department of Otolaryngology and Head and Neck Surgery, University Hospital, Linköping, Sweden.
    Bergholtz, Lars
    Östergötlands Läns Landsting. Department of Otolaryngology and Head and Neck Surgery, University Hospital, Linköping, Sweden.
    Otoneurological findings in psycho-organic syndrome caused by industrial solvent exposure1989In: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 107, no 1-2, p. 5-12Article in journal (Refereed)
    Abstract [en]

    Nine subjects with long-term (8-30 years) occupational exposure to industrial solvents and a confirmed diagnosis of psycho-organic syndrome (POS) have been studied with audiological and otoneurological test batteries. The results were compared to a matched control group of nine industrial workers not exposed to solvents and to normal data from healthy volunteers. In the clinical examination, the Romberg test identified 5/9 workers as pathologic and concurrently the stabilometry showed significantly larger sway areas in the POS-group. In the audiological test battery, the significantly pathologic tests were discrimination of interrupted speech and evoked cortical responses to frequency glides (CRA-delta-f). The saccade test disclosed abnormal findings in 5/9 workers. In the smooth pursuit test, abnormality was found at some test frequencies using pseudorandomized stimulus. The VOR-suppression test was significantly abnormal at all test frequencies. The test battery used strongly indicates CNS lesions due to industrial solvents.

  • 59.
    Rubin, Allan
    et al.
    Linköping University. University of Toronto, Canada.
    Liedgren, Christer
    Linköping University. University of Toronto, Canada.
    Ödkvist, Lars
    Linköping University. University of Toronto, Canada.
    Larsby, Birgitta
    Linköping University. University of Toronto, Canada.
    Aschan, Gunnar
    Linköping University. University of Toronto, Canada.
    Limb input to the cat vestibular nuclei1979In: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, ISSN ISSN 0001-6489, Vol. 87, no 1-2, p. 113-122Article in journal (Refereed)
    Abstract [en]

    The input from fore- and hindlimbs to the vestibular nuclear complex (VNC) was investigated in awake cats. Electrical stimulus was given to the sciatic, radial and vestibular nerves bilaterally and single unit responses were recorded in the VNC with extracellular technique. The position of the microelectrode was histologically confirmed. All four major vestibular nuclei received fore- as well as hindlimb input. Forty per cent of the neurons with limb input also received vestibular afferents. No major distinguishing features appeared between the different nuclei with regard to response characteristics. Certain differences in laterality of response, quantitative fore-hindlimb ratio and somatosensory-labyrinthine convergence were observed however. Response latencies to sciatic and radial nerve stimuli always exceeded a 3 msec and were grouped around 8 and 16 msec. A third population of vestibular neurons had latencies over 20 msec. Both excitatory and inhibitory responses were recorded, with the latter not always following an activation. The findings illustrate the complex nature of the ascending pathway to the VNC and the integrative properties of this complex.

  • 60.
    Sass, K.
    et al.
    Halmstad, Sverige.
    Ödkvist, Lars
    Linköping University, Department of Neuroscience and Locomotion, Oto-Rhiono-Laryngology and Head & Neck Surgery. Linköping University, Faculty of Health Sciences.
    Anniko, M.
    Uppsala, Sverige.
    Arlinger, Stig
    Linköping University, Department of Neuroscience and Locomotion, Technical Audiology. Linköping University, Faculty of Health Sciences.
    Barr, B.
    Stockholm, Sverige.
    Bergenius, J.
    Stockholm, Sverige.
    Billermark, Erica
    Linköping University, Department of Neuroscience and Locomotion, Oto-Rhiono-Laryngology and Head & Neck Surgery. Linköping University, Faculty of Health Sciences.
    Bonding, P.
    Köpenhamn, Danmark.
    Carlborg, B.
    Malmö, Sverige.
    Carlsson, P. I.
    Karlstad, Sverige.
    Larsen, H. C.
    Uppsala, Sverige.
    Ledin, Torbjörn
    Linköping University, Department of Neuroscience and Locomotion, Oto-Rhiono-Laryngology and Head & Neck Surgery. Linköping University, Faculty of Health Sciences.
    Magnusson, M.
    Lund, Sverige.
    Möller, C.
    Göteborg, Sverige.
    Padoan, S.
    Kristianstad, Sverige.
    Spandow, O.
    Oslo, Norge.
    Thomsen, J.
    Köpenhamn, Danmark.
    Öhman, H.
    Umeå, Sverige.
    Local overpressure treatment reduces vestibular symptoms in Meniere's disease2005In: Svensk ÖNH-tidskrift, ISSN 1400-0121, Vol. 12, no 1, p. 28-30Article in journal (Refereed)
  • 61.
    Skogman, Barbro H
    et al.
    Falun General Hospital, Sweden Centre Clin Research Dalarna, Sweden .
    Glimaker, Kajsa
    Linköping University, Department of Clinical and Experimental Medicine, Infectious Diseases. Linköping University, Faculty of Health Sciences.
    Nordwall, Maria
    Linköping University, Department of Clinical and Experimental Medicine, Pediatrics. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Department of Paediatrics in Norrköping.
    Vrethem, Magnus
    Linköping University, Department of Clinical and Experimental Medicine, Neurology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Local Health Care Services in Central Östergötland, Department of Neurology.
    Ödkvist, Lars
    Linköping University, Department of Clinical and Experimental Medicine, Oto-Rhiono-Laryngology and Head & Neck Surgery. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Sinnescentrum, Department of ENT - Head and Neck Surgery UHL.
    Forsberg, Pia
    Linköping University, Department of Clinical and Experimental Medicine, Infectious Diseases. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Centre, Department of Infectious Diseases in Östergötland.
    Long-term Clinical Outcome After Lyme Neuroborreliosis in Childhood2012In: Pediatrics, ISSN 0031-4005, E-ISSN 1098-4275, Vol. 130, no 2, p. 262-269Article in journal (Refereed)
    Abstract [en]

    OBJECTIVES: To determine long-term clinical outcome in children with confirmed Lyme neuroborreliosis (LNB) and to evaluate persistent subjective symptoms compared with a control group. less thanbrgreater than less thanbrgreater thanMETHODS: After a median of 5 years, 84 children with confirmed LNB underwent a neurologic re-examination, including a questionnaire. Medical records were analyzed, and a control group (n = 84) was included. less thanbrgreater than less thanbrgreater thanRESULTS: The total recovery rate was 73% (n = 61). Objective neurologic findings, defined as "definite sequelae," were found in 16 patients (19%). The majority of these children had persistent facial nerve palsy (n = 11), but other motor or sensory deficits occurred (n = 5). Neurologic signs and/or symptoms defined as "possible sequelae" were found in another 7 patients (8%), mainly of sensory character. Nonspecific subjective symptoms were reported by 35 patients (42%) and 32 controls (38%) (nonsignificant). Affected daily activities or school performance were reported to the same extent in both groups (23% vs 20%, nonsignificant). less thanbrgreater than less thanbrgreater thanCONCLUSIONS: The long-term clinical recovery rate was 73% in children with confirmed LNB. Persistent facial nerve palsy occurred in 13%, whereas other motor or sensory deficits were found in another 14%. Neurologic deficits did not affect daily activities or school performance more often among patients than controls and should be considered as mild. Furthermore, nonspecific subjective symptoms such as headache, fatigue, or memory or concentration problems were reported as often among patients as controls and should not be considered as sequelae after LNB.

  • 62.
    Tham, Richard
    et al.
    Linköping University. Department of Otorhinolaryngology, Linköping University, Sweden.
    Bunnfors, Irja
    Linköping University. Department of Clinical Pharmacology, Linköping University, Sweden.
    Eriksson, Birgitta
    Linköping University. Department of Otorhinolaryngology, Linköping University, Sweden.
    Larsby, Birgitta
    Linköping University. Department of Otorhinolaryngology, Linköping University, Sweden.
    Lindgren, S.
    Linköping University. Department of Clinical Pharmacology, Linköping University, Sweden.
    Ödkvist, Lars
    Linköping University. Department of Otorhinolaryngology, Linköping University, Sweden.
    Vestibulo-ocular disturbances in rats exposed to organic solvents1984In: Acta Pharmacologica et Toxicologica, ISSN 0001-6683, Vol. 54, no 1, p. 58-63Article in journal (Refereed)
    Abstract [en]

    The influence of different kinds of industrial solvents on the vestibular function of rats has been studied by recording nystagmus, induced by accelerated rotation. The effect was related to the blood levels of the solvents. One group of solvents, including halogenated saturated hydrocarbons like dichloromethane, caused depression of the vestibulo-oculomotor reflex (VOR). Another group, including benzene compounds like xylene, toluene, styrene and cumene and halogenated unsaturated hydrocarbons like trichloroethylene caused an excitation of the VOR. The most striking chemical similarity between the different solvents in the last group is the occurence of double-bonds. If the animals were exposed simultaneously to solvents from both groups the excitatory effect prevailed and was even potentiated. It is suggested that solvents cause depression or excitation of the VOR by interaction with central pathways in the reticular formation and the cerebellum.

  • 63.
    Tham, Richard
    et al.
    Linköping University.
    Larsby, Birgitta
    Linköping University.
    Eriksson, Birgitta
    Linköping University.
    Bunnfors, Irja
    Linköping University.
    Ödkvist, Lars
    Linköping University.
    Liedgren, Christer
    Östergötlands Läns Landsting.
    Electronystagmographic findings in rats exposed to styrene or toluene1982In: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 93, p. 107-112Article in journal (Refereed)
    Abstract [en]

    A previously described experimental model for studying the effect of industrial solvents in the vestibular system of rabbits has been applied to rats. To achieve a constant concentration, the solvent was infused intravenously, dissolved in a lipid emulsion. Arterial blood levels were estimated by gas chromatography. The vestibulo-oculomotor behaviour of rats during repeated rotatory acceleration was investigated by electronystagmography. The effect of two solvents-toluene and styrene-on the rotatory induced nystagmus was examined. Both solvents caused an exaggerated reaction at arterial blood  levels above 75 ppm. The investigation indicated that the rat will be suitable species for further electronystagmographic investigation of the influence of organic solvents on the vestibular system, for example in screening studies of the toxicity of these solvents.

  • 64.
    Tham, Richard
    et al.
    Linköping University. Department of Otorhinolaryngology, Linköping University, Sweden.
    Larsby, Birgitta
    Linköping University. Department of Otorhinolaryngology, Linköping University, Sweden.
    Eriksson, Birgitta
    Linköping University. Department of Otorhinolaryngology, Linköping University, Sweden.
    Ödkvist, Lars
    Linköping University. Department of Otorhinolaryngology, Linköping University, Sweden.
    Effects on the vestibulo- and opto-oculomotor system in rats by lesions of the commissural vestibular fibres1989In: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 108, no 5-6, p. 372-377Article in journal (Refereed)
    Abstract [en]

    Eye movements were recorded from rats with a magnetic search coil system before and after sectioning of the midline commissural pathways in the brain stem at the level of the vestibular nuclei. After lesion, the findings were as follows: 1) During sinusoidal vestibular stimulation the eyes moved in a sinusoidal way similar to the head movement without any regular saccades. There was a reduced gain and a phase lead. 2) During optokinetic stimulation the eyes moved in the stimulus direction to an excentric position and stayed there until stimulation ceased. 3) During acceleratory/deceleratory rotation in the light there was a drift of the eyes in the direction of the expected slow phase movement to an excentric position. In some animals there was a directional asymmetry. The findings may be explained by a failure of the central neural integrator for horizontal eye movements. The results support the hypothesis that vestibular commissural fibres are of crucial importance for the function of this integrator system.

  • 65.
    Tham, Richard
    et al.
    Linköping University.
    Larsby, Birgitta
    Linköping University.
    Hydén, Dag
    Linköping University.
    Aschan, Gunnar
    Linköping University.
    Ödkvist, Lars
    Linköping University.
    Pharmacokinetics of solvents in the experimental animal modell1977In: International symposium on the control of air pollution in the working environment, 1977, 1977, p. 92-98Conference paper (Other academic)
  • 66.
    Tham, Richard
    et al.
    Linköping University.
    Larsby, Birgitta
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    Möller, Claes
    Linköping University.
    Niklasson, Magnus
    Östergötlands Läns Landsting.
    Ödkvist, Lars
    Östergötlands Läns Landsting.
    Vestibulotoxicity of organic solvents1991In: Fourth international conference on combined effect of environmental factors / [ed] Laurence D. Fechter, Johns Hopkins University , 1991, p. 101-105Conference paper (Other academic)
  • 67.
    Tham, Richard
    et al.
    Linköping University.
    Larsby, Birgitta
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    Niklasson, Magnus
    Östergötlands Läns Landsting.
    Ödkvist, Lars
    Östergötlands Läns Landsting.
    Lesions of the commisural vestibular fibers in rats: The effect on the vestibulo- and opto-oculomotor system1988Conference paper (Other academic)
  • 68.
    Tham, Richard
    et al.
    Linköping University. Departments of Otolaryngology and Clinical Pharmacology, Regional-and University Hospital, Linköping University, Linköping, Sweden.
    Larsby, Birgitta
    Linköping University. Departments of Otolaryngology and Clinical Pharmacology, Regional-and University Hospital, Linköping University, Linköping, Sweden.
    Ödkvist, Lars
    Linköping University. Departments of Otolaryngology and Clinical Pharmacology, Regional-and University Hospital, Linköping University, Linköping, Sweden.
    Norlander, Björn
    Linköping University. Departments of Otolaryngology and Clinical Pharmacology, Regional-and University Hospital, Linköping University, Linköping, Sweden.
    Hydén, Dag
    Linköping University. Departments of Otolaryngology and Clinical Pharmacology, Regional-and University Hospital, Linköping University, Linköping, Sweden.
    Aschan, Gunnar
    Linköping University. Departments of Otolaryngology and Clinical Pharmacology, Regional-and University Hospital, Linköping University, Linköping, Sweden.
    The influence of trichlorethylene and related drugs on the vestibular system1979In: Acta Pharmacologica et Toxicologica, ISSN 0001-6683, Vol. 44, no 5, p. 336-342Article in journal (Refereed)
    Abstract [en]

    A previously described experimental model for studying the effect of industrial solvents on the vestibular system of rabbits has been applied to trichloroethylene. Estimation of trichloroethylene and its metabolites in blood and cerebrospinal fluid was performed by gas chromatography. Vestibular function was studied by recording nystagmus, induced by positional changes or accelerated rotation. At blood levels of trichloroethylene above 30 p.p.m. “positional nystagmus” develops. Two metabolites of trichloroethylene, chloral hydrate and trichloro-ethanol, which are known as central nervous system (CNS) depressants, did not induce this abnormal nystagmus. However, α-chloralose, a derivative of chloral hydrate, induced positional nystagmus and also a markedly exaggerated nystagmus developed during rotatory acceleration. It is suggested that solvents like trichloroethylene elicit vestibular disturbances by stimulation of central subcortical vestibulo-oculomotor connections. The stimulation may be caused by a blockage of inhibitory systems.

  • 69.
    Thomsen, J.
    et al.
    Dept. Otolaryngol./Head/Neck Surg., Gentofte University Hospital, 2900 Hellerup, Denmark.
    Sass, K.
    ENT Department, Halmstad, Sweden.
    Ödkvist, Lars
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Oto-Rhiono-Laryngology and Head & Neck Surgery . Östergötlands Läns Landsting, Reconstruction Centre, Department of ENT - Head and Neck Surgery UHL.
    Arlinger, Stig
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Oto-Rhiono-Laryngology and Head & Neck Surgery .
    Local overpressure treatment reduces vestibular symptoms in patients with Ménière's disease: A clinical, randomized, multicenter, double-blind, placebo-controlled study2005In: Otology and Neurotology, ISSN 1531-7129, E-ISSN 1537-4505, Vol. 26, no 1, p. 68-73Article in journal (Refereed)
    Abstract [en]

    Objectives: To evaluate the efficacy of a new device, the Meniett, in the treatment of Ménière's disease. The device delivers pressure pulses to the middle ear through a ventilating tube in the tympanic membrane at a frequency of 6 Hz for 0.6 second. After rising to a pressure level of 1.2 kPa, the pressure oscillates between 0.4 and 1.2 kPa. It is believed that the pressure changes are conveyed to the inner ear, inducing a transport of fluids via the pressure outlets and thus reducing the endolymphatic hydrops. Study Design: A clinical, randomized, multicenter, double-blind, placebo-controlled study. A total of 40 patients were included that had active Méniè re's disease according to American Academy of Otolaryngology-Head and Neck Surgery criteria, aged between 20 and 65 years, with a history of at least eight attacks during the past year. After insertion of the ventilation tube, the patients should have had attacks of vertigo for 2 months before entering the study. Outcome Measures: Primary study endpoints were change in frequency of vertigo, change of functionality profile, and change in patient perception of vertigo (visual analogue scale), secondary endpoints were perception of tinnitus, aural pressure, and hearing, as well as an audiologic evaluation of hearing before and after the treatment period. Results: The functionality level improved statistically significantly in the active group compared with the placebo group (p = 0.0014), as did the visual analogue scale evaluation of vertigo (p = 0.005). There was a trend toward a reduction of the frequency of vertiginous attacks that was not significant (p = 0.090). With regard to the secondary endpoints, there was no statistical difference between active and placebo groups. Conclusion: Local overpressure treatment is a novel treatment that is noninvasive, nondestructive, and safe. It significantly reduces vestibular symptoms in patients with Ménière's disease. The Meniett was cleared by the Food and Drug Administration in 2000.

  • 70.
    Ödkvist, Lars
    et al.
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Oto-Rhiono-Laryngology and Head & Neck Surgery. Östergötlands Läns Landsting, RC - Rekonstruktionscentrum, ÖNH - Öron- Näsa- Halskliniken.
    Arlinger, Stig
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Technical Audiology. Östergötlands Läns Landsting, RC - Rekonstruktionscentrum, ÖNH - Öron- Näsa- Halskliniken.
    Billermark, Erica
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Oto-Rhiono-Laryngology and Head & Neck Surgery. Östergötlands Läns Landsting, RC - Rekonstruktionscentrum, ÖNH - Öron- Näsa- Halskliniken.
    Densert, B
    Lindholm, S
    Wallqvist, J
    Effects of middle ear pressure changes on clinical symptoms in patients with MΘniΦre's disease - A clinical multicentre placebo-controlled study2000In: Acta oto-laryngologica. Supplementum, ISSN 0365-5237, E-ISSN 1651-2464, no 543, p. 99-101Article in journal (Refereed)
    Abstract [en]

    Different medical and surgical methods have been tried in attempting to reduce endolymphatic pressure in MΘniΦre's disease. Pressure treatment has a role on the treatment staircase, after pharmacological treatment and before destructive methods. Pressure chamber treatment has shown that some patients respond well to the treatment with diminishing inner ear symptoms and also some hearing improvement. Earlier studies have shown that electrocochlear measurements improve after local pressure treatment in the ear. The present study was a prospective randomized placebo controlled, multicentre clinical trial. 56 patients with active MΘniΦre's disease, age 20-65 years, with a hearing loss of 20-65 dB PTA participated. A total of 31 patients completed 2 weeks use with an active apparatus (Meniett) and 25 patients completed the 2 weeks with the placebo gadget. Both machines were produced by Pascal Medical, Halmstad, Sweden. Two weeks before the start of treatment a grommet was placed in the tympanic membrane. A significant improvement concerning frequency and intensity of vertigo, dizziness, aural pressure and tinnitus was reported by the active group on the visual analogue scales (VAS) questionnaire. In the placebo group no change was the most common finding, followed by worsening of the symptoms and a few improvements. The function in professional and family life improved during active treatment and did not during placebo treatment. Pure-tone audiometry did not improve after placebo treatment, but improved at the frequencies 500 Hz and 1,000 Hz after active treatment. The study showed an improvement in the inner ear symptoms after Meniett treatment. The mechanism may be explained by the influence on the round window membrane pressure receptors or an endolymphatic flow out through the pressure release points, such as the endolymphatic duct and sac, thus activating the longitudinal flow. Other mechanisms are also possible.

  • 71.
    Ödkvist, Lars
    et al.
    Linköping University. Departments of Otolaryngology, University Hospital, Linköping, Sweden.
    Arlinger, Stig
    Linköping University. Audiology, University Hospital, Linköping, Sweden.
    Edling, Christer
    Östergötlands Läns Landsting. Occupational Medicine, University Hospital, Linköping, Sweden.
    Larsby, Birgitta
    Linköping University. Departments of Otolaryngology, University Hospital, Linköping, Sweden.
    Bergholtz, Lars
    Östergötlands Läns Landsting. Audiology, University Hospital, Linköping, Sweden.
    Audiological and vestibulo-oculomotor findings in workers exposed to solvents and jet fuel1987In: Scandinavian Audiology, ISSN 0105-0397, E-ISSN 1940-2872, Vol. 16, no 2, p. 75-81Article in journal (Refereed)
    Abstract [en]

    Three groups of subjects with long-term (5-41 years) occupational exposure to industrial solvents have been evaluated with extensive audiological and vestibular test batteries. Group A comprised 16 subjects with a confirmed diagnosis of psycho-organic syndrome (POS), while group B consisted of 7 subjects with suspected POS. Both groups had been exposed to mixtures of aliphatic and aromatic solvents. Eight subjects with long-term exposure to jet fuel constituted group C. In the audiological test battery, discrimination of interrupted speech and evoked cortical potentials in response to frequency glides were the tests that yielded significantly abnormal results. In the vestibular test battery, considerable pathology was seen in electronystagmography, and in addition, visual suppression test and saccade test indicated CNS disturbance. In general, when a test yielded pathological results, the incidence of pathology was highest in group A and lowest in group C.

  • 72.
    Ödkvist, Lars
    et al.
    Linköping University.
    Bergholtz, Lars
    Östergötlands Läns Landsting.
    Larsby, Birgitta
    Linköping University.
    Tham, Richard
    Linköping University.
    Eriksson, Birgitta
    Linköping University.
    Edling, Christer
    Solvent induced central nervous system disturbances appearing in hearing and vestibulo-oculomotor tests1985In: Clinical Ecology, ISSN 0735-9306, Vol. 3, no 3, p. 149-153Article in journal (Refereed)
  • 73.
    Ödkvist, Lars
    et al.
    Östergötlands Läns Landsting. Department of Otolaryngology, University Hospital, Linkoping, Sweden.
    Fredrickson, John
    University of Toronto, Canada.
    Larsby, Birgitta
    Linköping University. Department of Otolaryngology, University Hospital, Linkoping, Sweden.
    Projection of the vestibular nerve to the SI arm field in the cerebral cortex of the cat1975In: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 79, no 1-2, p. 88-95Article in journal (Refereed)
    Abstract [en]

    Evoked cortical focal potentials from electrical vestibular nerve stimulation were recorded in the Pcd-area in cats anaesthetized with Chloralose or Nembutal. For comparison, additional cortical projections were located for n. rad. superficialis and group Ia muscle afferents from n. rad. prof., n. fibularis prof., n. femuralis ramus muscularis and the motor nerve to the trapezoid muscle. Surface positive potentials, which reversed to negativity in middle cortical layers, were for vestibular nerve stimulation recorded in the S I forelimb field in a small area close to Pcd in the posterior medial part of the deep radial nerve projection field. The location of this field is compared with the vestibulo-cortical projections described earlier for rodents, squirrel monkey, and rhesus monkey. The histology shows that the field was within the cytoarchitectonic 3a area.

  • 74.
    Ödkvist, Lars
    et al.
    Östergötlands Läns Landsting.
    Gripmark, M.
    Östergötlands Läns Landsting.
    Larsby, Birgitta
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    Ledin, Torbjörn
    Östergötlands Läns Landsting.
    The subjective horizontal in eccentric rotation influenced by peripheral vestibular lesion1996In: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 116, no 2, p. 181-184Article in journal (Refereed)
    Abstract [en]

    Peripheral vestibular equilibrium disorders may originate in various parts of the labyrinth or the vestibular nerve. Traditionally, the function of the lateral semicircular canals has been assessed with caloric irrigation, and sometimes falsely been interpreted as a vestibular nerve lesion. the vertical semicircular canals are not easily assessed. Caloric testing with the head in different positions is not very helpful, but the canals may pairwise be tested using specific rotational techniques. Often the otolithic organs, capable of detecting linear acceleration forces, are forgotten as a source of vertigo and dizziness. We have implemented horizontal rotatory testing with the subject seated eccentrically facing the direction of rotation as a means of assessing otolithic function. the subject experiences a lateral tilt and is instructed in darkness to put a short light bar in the position he thinks a water surface would have, which is identical to his perceived tilt. in 39 normal subjects, a theoretical tilt of 24° was estimated as approximately 19.5°, and the standard deviation was 6°. A side difference index was proposed to be normal if below 25%. the preliminary findings in a few patients with known labyrinthine lesions are presented. We propose that otolithic as well as lateral semicircular canal functions are useful to monitor in patients with suspected peripheral equilibrium disorders.

  • 75.
    Ödkvist, Lars
    et al.
    Linköping University.
    Hydén, Dag
    Linköping University.
    Andersson, Hans
    Östergötlands Läns Landsting.
    Larsby, Birgitta
    Linköping University.
    The visual suppression test1983In: Proc NES 1983, 1983Conference paper (Other academic)
  • 76.
    Ödkvist, Lars
    et al.
    Linköping University.
    Jerlvall, T.
    Andersson, Hans
    Östergötlands Läns Landsting.
    Larsby, Birgitta
    Linköping University.
    Hydén, Dag
    Linköping University.
    A computerized saccade test - clinical value1983In: Proc NES 1983, 1983, p. 202-208Conference paper (Other academic)
  • 77.
    Ödkvist, Lars
    et al.
    Östergötlands Läns Landsting.
    Larsby, Birgitta
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    Hydén, Dag
    Linköping University.
    Rotatory tests1993In: NES 1993, 1993Conference paper (Other academic)
  • 78.
    Ödkvist, Lars
    et al.
    Linköping University.
    Larsby, Birgitta
    Linköping University.
    Hydén, Dag
    Linköping University.
    Aschan, Gunnar
    Linköping University.
    Tham, Richard
    Linköping University.
    Influence of industrial solvents on the balance system1977In: International symposium on the control of air pollution in the working environment, 1977, 1977, p. 80-87Conference paper (Other academic)
  • 79.
    Ödkvist, Lars
    et al.
    Östergötlands Läns Landsting.
    Larsby, Birgitta
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    Ledin, Torbjörn
    Linköping University. Östergötlands Läns Landsting.
    Eccentric rotation as a means to assess otolith function: normal subjects and findings in unilateral Menieres Disease1996Conference paper (Other academic)
  • 80.
    Ödkvist, Lars
    et al.
    Linköping University. Departments of Otolaryngology and Clinical Pharmacology, Regional-and University Hospital, Linköping University, Linköping, Sweden.
    Larsby, Birgitta
    Linköping University. Departments of Otolaryngology and Clinical Pharmacology, Regional-and University Hospital, Linköping University, Linköping, Sweden.
    Liedgren, Christer
    Linköping University. Departments of Otolaryngology and Clinical Pharmacology, Regional-and University Hospital, Linköping University, Linköping, Sweden.
    Fredrickson, John
    University of Toronto, Canada.
    Tham, Richard
    Linköping University. Departments of Otolaryngology and Clinical Pharmacology, Regional-and University Hospital, Linköping University, Linköping, Sweden.
    Vestibular and oculomotor disturbances caused by industrial solvents1980In: Journal of Otolaryngology, ISSN 0381-6605, Vol. 9, no 1, p. 53-59Article in journal (Refereed)
    Abstract [en]

    Hydrocarbon solvents, xylene, styrene, methylchloroform, and trichlorethylene, given intravenously to rabbits produce a positional nystagmus. Due to their additional influence on rotatory nystagmus, one may conclude that their mode of action takes place in the central nervous system. Optokinetic (OKN) responses in rabbits, cats, and humans were also influenced by styrene. OKN responses have not yet been tested for the other solvents. A comparison is made with the effects of alpha-chloralose and the GABA-antagonists bicuculline and picrotoxin which produced similar disturbances. The GABA agonist, baclofen, prevents positional induced styrene nystagmus. It seems likely therefore that the solvents may act by blocking the cerebellar inhibition of vestibulo-oculomotor reflexes. Solvents given simultaneously in some combinations are either

  • 81.
    Ödkvist, Lars
    et al.
    Linköping University.
    Larsby, Birgitta
    Linköping University.
    Liedgren, Christer
    Östergötlands Läns Landsting.
    Tham, Richard
    Linköping University.
    Disturbancies of the oculomotor system caused byhydrocarbon solvents1981In: Functional basis of Ocular Motility Disorders, 1981, 1981, p. 535-536Conference paper (Other academic)
  • 82.
    Ödkvist, Lars
    et al.
    Linköping University. Department of Otolaryngology and Department of Clinical Pharmacology, Regional and University Hospital, Linköping University, Linköping, Sweden.
    Larsby, Birgitta
    Linköping University. Department of Otolaryngology and Department of Clinical Pharmacology, Regional and University Hospital, Linköping University, Linköping, Sweden.
    Tham, Richard
    Linköping University. Department of Otolaryngology and Department of Clinical Pharmacology, Regional and University Hospital, Linköping University, Linköping, Sweden.
    Aschan, Gunnar
    Linköping University. Department of Otolaryngology and Department of Clinical Pharmacology, Regional and University Hospital, Linköping University, Linköping, Sweden .
    On the mechanisms of vestibular disturbancies caused by industrial solvents1979In: Advances in Oto-Rhino-Laryngology, ISSN 0065-3071, E-ISSN 1662-2847, Vol. 25, p. 167-172Article in journal (Refereed)
    Abstract [en]

    The industrial solvents xylene, styrene, trichloroethylene and methylchloroform administered to rabbits caused a positional nystagmus and disturbances in the nystagmus response to rotatory acceleration. The positional nystagmus had a beat direction the opposite to positional alcohol nystagmus, which was in similar experiments elicited by methanol, ethanol and propanol. The three alcohols needed a ten times higher blood concentration to cause a nystagmus than the solvents did.

  • 83.
    Ödkvist, Lars
    et al.
    Linköping University.
    Larsby, Birgitta
    Linköping University.
    Tham, Richard
    Linköping University.
    Hydén, Dag
    Linköping University.
    Vestibular oculomotor dysfunction caused by solvents1982In: Nordic symposium on data processing of eye movements 1982, 1982Conference paper (Other academic)
  • 84.
    Ödkvist, Lars
    et al.
    Linköping University.
    Larsby, Birgitta
    Linköping University.
    Tham, Richard
    Linköping University.
    Hydén, Dag
    Linköping University.
    Vestibulo-oculomotor disturbances caused by industrial solvents1983In: Otolaryngology - Head and Neck Surgery, ISSN 0194-5998, Vol. 91, no 5, p. 537-539Article in journal (Refereed)
    Abstract [en]

    Animal experiments show that intoxication with hydrocarbon solvents influences the vestibulo-oculomotor reflex arc and indicate that the solvents block the inhibition of the vestibulo-oculomotor reflex presumably exerted by the cerebellum. The blood concentrations necessary to elicit oculomotor disturbances in animals were smaller than those that disturbed the vestibular function. Accordingly, in human experiments styrene and toluene exposure did not elicit any positional nystagmus but caused an increased saccade speed and a diminished visual suppression of vestibular nystagmus. Some cerebellar clinical pathologic process in patients who suffer from a psycho-organic syndrome caused by solvents leads us to believe that the cerebellum might be the most vulnerable part of the brain. Some patients had a positional nystagmus, but the most prominent pathologic signs were elicited by the visual suppression test. Our findings compare well with the increased saccade speed and diminished visual suppression in patients with cerebellar tumors and infarctions

  • 85.
    Ödkvist, Lars
    et al.
    Linköping University.
    Larsby, Birgitta
    Linköping University.
    Tham, Richard
    Linköping University.
    Liedgren, Christer
    Östergötlands Läns Landsting.
    Aschan, Gunnar
    Linköping University.
    Positional nystagmus elicited by industrial solvents1978In: Vestibular mechanisms in health and disease, 1978 / [ed] Hood JD, Academic Press, 1978, p. 18-27Conference paper (Other academic)
  • 86.
    Ödkvist, Lars
    et al.
    Linköping University. Departments of Otolaryngology and Clinical Pharmacology, University Hospital, Linköping, Sweden .
    Larsby, Birgitta
    Linköping University. Departments of Otolaryngology and Clinical Pharmacology, University Hospital, Linköping, Sweden.
    Tham, Richard
    Linköping University. Departments of Otolaryngology and Clinical Pharmacology, University Hospital, Linköping, Sweden.
    Åhlfeldt, H.
    Linköping University. Departments of Otolaryngology and Clinical Pharmacology, University Hospital, Linköping, Sweden.
    Andersson, Björn
    Linköping University. Departments of Otolaryngology and Clinical Pharmacology, University Hospital, Linköping, Sweden.
    Eriksson, Birgitta
    Linköping University. Departments of Otolaryngology and Clinical Pharmacology, University Hospital, Linköping, Sweden.
    Liedgren, Christer
    Linköping University. Departments of Otolaryngology and Clinical Pharmacology, University Hospital, Linköping, Sweden.
    Vestibulo-oculomotor disturbances in humans exposed to styrene1982In: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 94, no 1-6, p. 487-493Article in journal (Refereed)
    Abstract [en]

    Several reports indicate that disturbances of the vestibulo-oculomotor ability are a manifestation of the toxic action on the central nervous system exerted by some industrial solvents. The aim of the present investigation was to examine the vestibulo-oculomotor system during exposure to styrene, which is extensively used in the production of plastics. Healthy volunteers were exposed to styrene for one hour. Rotatory and optokinetic nystagmus, visual suppression as well as speed, latency and accuracy of saccades were tested before, during, and one hour after the exposure. The pulmonary uptake and the blood level of the solvent were continuously analysed by gas chromatography. The styrene blood concentration was equivalent to that which may well be reached after several hours of hard work in an industrial environment with a concentration of styrene within permitted limits. No spontaneous nystagmus appeared. The rotatory and optokinetic nystagmus was not influenced by styrene. However, the speed of the saccade was significantly enhanced. The visual suppression was disturbed, shown by an increased gain after styrene exposure. The experiments thus indicate that styrene given to healthy test persons induced disturbances, thus consistent with the theory that some organic solvents block the cerebellar inhibition of the vestibulo-oculomotor system.

  • 87.
    Ödkvist, Lars
    et al.
    Östergötlands Läns Landsting.
    Ledin, Torbjörn
    Linköping University.
    Larsby, Birgitta
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    Gripmark, M.
    Noaksson, Lisbeth
    Östergötlands Läns Landsting.
    Olsson, S.
    Östergötlands Läns Landsting.
    Otolithic tests in Menière’s disease1995In: Ménièr's Disease, 1995 / [ed] Vesterhauge S, Katholm M, Mikines P, 1995, p. 259-265Conference paper (Other academic)
  • 88.
    Ödkvist, Lars
    et al.
    Östergötlands Läns Landsting.
    Liedgren, Christer
    Östergötlands Läns Landsting.
    Larsby, Birgitta
    Östergötlands Läns Landsting.
    Jerlvall, L.
    Östergötlands Läns Landsting.
    Vestibular and somatosensory inflow to the vestibular projection area in the post cruciate dimple region of the gat cerebral cortex1975In: Experimental Brain Research, ISSN 0014-4819, E-ISSN 1432-1106, Vol. 22, no 2, p. 185-196Article in journal (Refereed)
    Abstract [en]

    In anesthetized cats 251 cells within the cortical vestibular projection area, adjacent to the post-cruciate dimple, were analyzed as to their input characteristics employing extracellular recording techniques. The post cruciate dimple vestibular field, which is located in area 3a, has a high degree of convergence between vestibular and peripheral somatosensory input. The latter is not restricted to muscle afferents but includes cutaneous modalities. The functional significance of this vestibular cortical projection field is discussed.

  • 89.
    Ödkvist, Lars
    et al.
    Linköping University.
    Möller, C.
    Linköping University.
    Thell, Jan
    Östergötlands Läns Landsting.
    Larsby, Birgitta
    Linköping University.
    Hydén, Dag
    Linköping University.
    Gentamycin-treated Meniere's disease evaluated by rotatory tests1985In: Myers E, editor.; Elsevier SiencePublishers B.V.; 1985 / [ed] Myers E,, 1985, p. 43-44Conference paper (Other academic)
  • 90.
    Ödkvist, Lars
    et al.
    Östergötlands Läns Landsting.
    Möller, Claes
    Linköping University.
    Hydén, Dag
    Linköping University.
    Larsby, Birgitta
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    Vestibulr Compensation Measured by the Broad-Frequency Band Rotatory Test1987In: The Vestibular system: Neurophysiologic and clinical research / [ed] Malcolm D. Graham, John L. Kemink, New York: Raven Press , 1987, p. 287-291Conference paper (Refereed)
  • 91.
    Ödkvist, Lars
    et al.
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Oto-Rhiono-Laryngology and Head & Neck Surgery. Östergötlands Läns Landsting, Reconstruction Centre, Department of ENT - Head and Neck Surgery UHL.
    Noaksson, L M
    Greibe, Patrick
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Oto-Rhiono-Laryngology and Head & Neck Surgery. Östergötlands Läns Landsting, Reconstruction Centre, Department of ENT - Head and Neck Surgery UHL.
    Ledin, Torbjörn
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Oto-Rhiono-Laryngology and Head & Neck Surgery. Östergötlands Läns Landsting, Reconstruction Centre, Department of ENT - Head and Neck Surgery UHL.
    Neurootology in neck trauma patients2004In: Bárány Society XXIII International Congress,2004, 2004, p. 156-156Conference paper (Other academic)
  • 92.
    Ödkvist, Lars
    et al.
    Linköping University.
    Tham, Richard
    Linköping University.
    Hydén, Dag
    Linköping University.
    Larsby, Birgitta
    Linköping University.
    Edling, Christer
    Bergholtz, Lars
    Östergötlands Läns Landsting.
    Tidig diagnostik vid lösningsmedelsskada1982In: Sv Otolaryngol förening 1982;2, 1982, p. 2-Conference paper (Other academic)
  • 93.
    Ödkvist, Lars
    et al.
    Linköping University.
    Tham, Richard
    Linköping University.
    Larsby, Birgitta
    Linköping University.
    Aschan, Gunnar
    Linköping University.
    Liedgren, Christer
    Östergötlands Läns Landsting.
    Hur inverkar industriella lösningsmedel på balansapparaten1978In: Läkaresällskapets riksstämma 1978, 1978Conference paper (Other academic)
  • 94.
    Ödkvist, Lars
    et al.
    Linköping University.
    Tham, Richard
    Linköping University.
    Åhlfeldt, H.
    Linköping University.
    Andersson, Björn
    Linköping University.
    Liedgren, Christer
    Östergötlands Läns Landsting.
    Larsby, Birgitta
    Linköping University.
    Vestibulo-oculomotor findings during styrene exposure1981In: World Congress of Otolaryngol 1981, 1981Conference paper (Other academic)
  • 95.
    Ödkvist, Lars
    et al.
    Linköping University.
    Thell, Jan
    Östergötlands Läns Landsting.
    Hydén, Dag
    Linköping University.
    Larsby, Birgitta
    Linköping University.
    Vascular cause for vertigo1986In: Claussen C-F, Kirtane MV, editors. Vertigo, nausea,tinnitus and hearing loss in cardiovasculr disease.: Elsevier SciencePublishers B.V.; 1986, 1986, p. 61-68Conference paper (Other academic)
  • 96.
    Ödkvist, Lars
    et al.
    Linköping University. Department of Otolaryngology, University Hospital, Linköping, Sweden..
    Thell, Jan
    Östergötlands Läns Landsting. Department of Otolaryngology, University Hospital, Linköping, Sweden..
    Larsby, Birgitta
    Linköping University. Department of Otolaryngology, University Hospital, Linköping, Sweden..
    A comparison between smooth pursuit and visual suppression1988In: Advances in Oto-Rhino-Laryngology, ISSN 0065-3071, E-ISSN 1662-2847, Vol. 41, p. 109-115Article in journal (Refereed)
  • 97.
    Ödkvist, Lars
    et al.
    Linköping University.
    Åstrand, I.
    Arbetsmiljöinstitutet.
    Larsby, Birgitta
    Linköping University.
    Käll, K.
    Arbetsmiljöinstitutet.
    Ger lösningsmedel störningar i vestibulo-oculomotorsystemet ?1980In: Arbete och Hälsa, ISSN 0346-7821, Vol. 2, no 1Article in journal (Other academic)
12 51 - 97 of 97
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