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  • 251.
    Hakeberg, Magnus
    et al.
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Oral health.
    Hägglin, C
    Berggren, U
    Carlsson, S G
    Structural relationships of dental anxiety, mood, and general anxiety.2001In: Acta Odontologica Scandinavica, ISSN 0001-6357, E-ISSN 1502-3850, Vol. 59, no 2, p. 99-103Article in journal (Refereed)
  • 252.
    Hakeberg, Magnus
    et al.
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine.
    Jonsson, Roland
    Läppbiopsi av submukösa spottkörtlar i diagnostiken av sarkoidos1987In: Tandläkartidningen, ISSN 0039-6982, Vol. 79, no 20, p. 1085-1087Article in journal (Refereed)
  • 253.
    Hakeberg, Magnus
    et al.
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Oral health.
    Klingberg, G
    Noren, J G
    Berggren, U
    Swedish dentists' perceptions of their patients.1992In: Acta Odontologica Scandinavica, ISSN 0001-6357, E-ISSN 1502-3850, Vol. 50, no 4, p. 245-252Article in journal (Refereed)
  • 254.
    Hall, Elinore
    et al.
    Jönköping University, School of Health and Welfare, HHJ, Dep. of Natural Science and Biomedicine.
    Tanja, Nijemcevic
    Jönköping University, School of Health and Welfare, HHJ, Dep. of Natural Science and Biomedicine.
    Metodverifiering med KRYPTOR compact PLUS samt fördjupad litteraturgenomgång av förekommande kliniskt biokemiska analysmetoder för Chromogranin A i plasma och serum.2016Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Title: Verification on KRYPTOR compact PLUS and an in-depth literature overview of clinical biochemical assays for the detection of Chromogranin A in plasma and serum.

     

    Cancer is constantly increasing. Simultaneously, there is an increase in survival for cancer patients due to early diagnosis and better treatment.  Neuroendocrine tumour disease is diagnosed with help of tumour marker chromogranin A. The aim of this study was to narrate and compare clinical biochemical methods for the detection of chromogranin A in plasma and serum. In addition, a verification of KRYPTOR, BRAHMS automated immunofluorescent assay (KRYPTOR) for chromogranin A was performed. Occurring methods for analysis was investigated by in-depth literature overview. Verification contained tests for carry over, intra- and inter-assay, comparison with same method and radioimmunoassay method respectively. The literature overview resulted in radioimmunoassay, immunoradiometric assay, enzyme linked immunosorbent assay and KRYPTOR/immunochemiluminometric assay. Verification gave carry over 0.04%, inter-assay CV 1.96% and 2.33%, intra-assay CV 2.85%. Comparison with the same method gave a mean difference of 17.6% and five samples out of six correlated for comparison with radioimmunoassay. In summary, four immunological methods are used for analysis of chromogranin A, within research. Their development ranges from radioactive manual to non-radioactive automated method with shortened analysis times. Verification for KRYPTOR showed god intra- and inter-assay but an insufficient number of samples resulted in low reliability.

  • 255.
    Hallgren, Jenny
    et al.
    Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology. Jönköping University, School of Health and Welfare, HHJ. ARN-J (Aging Research Network - Jönköping).
    Fransson, EIeonor
    Jönköping University, School of Health and Welfare, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health and Welfare, HHJ. ARN-J (Aging Research Network - Jönköping). Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
    Reynolds, Chandra A.
    Department of Psychology, University of California, Riverside, United States.
    Finkel, Deborah
    Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology. Jönköping University, School of Health and Welfare, HHJ. ARN-J (Aging Research Network - Jönköping). School of Social Sciences, Indiana University Southeast, New Albany, United States.
    Pedersen, Nancy L.
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
    Dahl Aslan, Anna K.
    Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology. Jönköping University, School of Health and Welfare, HHJ. ARN-J (Aging Research Network - Jönköping). Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
    Cognitive trajectories in relation to hospitalization among older Swedish adults2018In: Archives of gerontology and geriatrics (Print), ISSN 0167-4943, E-ISSN 1872-6976, Vol. 74, p. 9-14Article in journal (Refereed)
    Abstract [en]

    INTRODUCTION:

    Research indicate that cognitive impairment might be related to hospitalization, but little is known about these effects over time.

    OBJECTIVE:

    To assess cognitive change before and after hospitalization among older adults in a population-based longitudinal study with up to 25 years of follow-up.

    METHOD:

    A longitudinal study on 828 community living men and women aged 50-86 from the Swedish Adoption/Twin Study of Ageing (SATSA) were linked to The Swedish National Inpatient Register. Up to 8 assessments of cognitive performance (general cognitive ability, verbal, spatial/fluid, memory, and processing speed) from 1986 to 2010 were available. Latent growth curve modelling was used to assess the association between cognitive performance and hospitalization including spline models to analyse cognitive trajectories pre- and post-hospitalization.

    RESULTS:

    A total of 735 persons (89%) had at least one hospital admission during the follow-up. Mean age at first hospitalization was 70.2 (±9.3)years. Persons who were hospitalized exhibited a lower mean level of cognitive performance in general ability, processing speed and spatial/fluid ability compared with those who were not hospitalized. The two-slope models revealed steeper cognitive decline before hospitalization than after among those with at least one hospitalization event, as compared to non-hospitalized persons who showed steeper cognitive decline after the centering age of 70 years.

    CONCLUSIONS:

    Persons being hospitalized in late life have lower cognitive performance across all assessed domains. The results indicate that the main decline occurs before the hospitalization, and not after. This might indicate that when you get treatment you also benefit cognitively.

  • 256.
    Hallgren, Jenny
    et al.
    Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology.
    Fransson, Eleonor I.
    Jönköping University, School of Health and Welfare, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health and Welfare, HHJ. ADULT. Jönköping University, School of Health and Welfare, HHJ. ARN-J (Aging Research Network - Jönköping). Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology.
    Finkel, Deborah G.
    Dahl Aslan, Anna K.
    Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology. Jönköping University, School of Health and Welfare, HHJ. ARN-J (Aging Research Network - Jönköping).
    Trajectories of motor function and cognition in relation to hospitalization2017Conference paper (Refereed)
    Abstract [en]

    Background: Hospitalization among older people is common and associated with adverse outcomes. However, knowledge about long-term effects on motor functions and cognitive abilities in relation to hospitalization is scarce. In order to explore development of motor functions and cognition after hospitalization, a longitudinal study among middle-aged and older adults with up to 25 years of follow-up was conducted.

    Methods: Overall, 828 participants from the Swedish Adoption/Twin Study of Ageing (SATSA) were linked to the Swedish National Inpatient Register, which contains information on participants’ hospital admissions. Up to 8 assessments of cognitive performance and 7 assessments of motor functions i.e. fine motor, balance/upper strength, and flexibility, from 1986 to 2010 were available. Latent growth curve modelling was used to assess the association between hospitalization and subsequent motor function and cognitive performance.

    Results: A total of 735 (89 %) persons had at least one hospital admission during the follow-up. The mean age at first hospitalization was 70.2 (± 9.3) years. Persons who were hospitalized exhibited a lower mean level of cognitive performance in all domains and in motor functions compared with those who were not hospitalized. A significantly steeper decline was observed in motor function abilities as well as in processing speed, spatial/fluid, and general cognitive ability performance of hospitalized participants. These patterns remained even after comorbidities and dementia prevalence were controlled for.

    Discussion: We are the first to show that hospitalization is associated with steeper decline in both motor function and cognitive abilities across more than two decades of post-hospitalization follow-up.

  • 257.
    Hallgren, Jenny
    et al.
    Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology. Jönköping University, School of Health and Welfare, HHJ. Ageing - living conditions and health.
    Fransson, Eleonor I.
    Jönköping University, School of Health and Welfare, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health and Welfare, HHJ. Ageing - living conditions and health.
    Kåreholt, Ingemar
    Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology.
    Reynolds, Chandra A.
    Department of Psychology, University of Southern California, Riverside, USA.
    Pedersen, Nancy L.
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
    Dahl Aslan, Anna K.
    Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology. Jönköping University, School of Health and Welfare, HHJ. Ageing - living conditions and health.
    Factors associated with hospitalization risk among community living middle aged and older persons: results from the Swedish Adoption/TwinStudy of Aging (SATSA)2016In: Archives of gerontology and geriatrics (Print), ISSN 0167-4943, E-ISSN 1872-6976, Vol. 66, p. 102-108Article in journal (Refereed)
    Abstract [en]

    The aims of the present study were to: (1) describe and compare individual characteristics of hospitalized and not hospitalized community living persons, and (2) to determine factors that are associated with hospitalization risk over time. We conducted a prospective study with a multifactorial approach based on the population-based longitudinal Swedish Adoption/Twin Study of Aging (SATSA). A total of 772 Swedes (mean age at baseline 69.7 years, range 46–103, 59.8% females) answered a postal questionnaire about physical and psychological health, personality and socioeconomic factors. During nine years of follow-up, information on hospitalizations and associated diagnoses were obtained from national registers. Results show that 484 persons (63%) had at least one hospital admission during the follow-up period. The most common causes of admission were cardiovascular diseases (25%) and tumors (22%). Cox proportional hazard regression models controlling for age, sex and dependency within twin pairs, showed that higher age (HR = 1.02, p < 0.001) and more support from relatives (HR = 1.09, p = 0.028) were associated with increased risk of hospitalization, while marital status (unmarried (HR = 0.75, p = 0.033) and widow/widower (HR = 0.69, p < 0.001)) and support from friends (HR = 0.93, p = 0.029) were associated with lower risk of hospitalization. Social factors were important for hospitalization risk even when medical factors were controlled for in the analyses. Number of diseases was not a risk in the final regression model. Hospitalization risk was also different for women and men and within different age groups. We believe that these results might be used in future interventions targeting health care utilization.

  • 258.
    Hallgren, Jenny
    et al.
    Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology.
    Fransson, Eleonor
    Jönköping University, School of Health and Welfare, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health and Welfare, HHJ. ADULT.
    Reynolds, C. A.
    University of California, USA.
    Pedersen, Nancy L.
    Karolinska Institutet.
    Dahl, Anna K.
    Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology. Jonkoping Univ, Sch Hlth Sci, Inst Gerontol, Jonkoping, Sweden.;Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden..
    Factors associated with hospitalization among older people in Sweden: Results from the Satsa Study2015In: The Gerontologist, ISSN 0016-9013, E-ISSN 1758-5341, Vol. 55, p. 678-679Article in journal (Refereed)
    Abstract [en]

    Background: Hospitalization among older people is common and associated with risk of adverse outcomes such as iatrogenic disorders and physical impairments. Knowledge about personal characteristics and social factors related to hospitalization is scarce. In order to understand which factors that are related to hospitalization risk, a prospective study with a multifactorial approach was conducted.

    Methods: In 2003, 794 Swedish persons (mean age 70.1 years, 60.7% females) answered a postal questionnaire as a part of the population-based longitudinal Swedish Adoption/Twin Study of Aging (SATSA). Participants were asked about physiological and psychological health, personality and socio economic factors. During seven years of follow-up, information on hospitalizations and the associated diagnoses were obtained from the Swedish National Inpatient Register.

    Results: Preliminary results show that 484 persons (61.0%) had at least one hospital admission during the follow-up period. The most common causes of admission were cardiovascular diseases and tumors. Cox proportional hazard regression model controlling for age, sex and dependency within twin pairs, showed that higher locus of control (HR=0.89, 95% CI=0.83-0.96), marital status (widow/widower (HR=0.64, 95 % CI=0.50-0.81) and unmarried (HR=0.67, 95% CI=0.50-0.90)), and support from friends (HR=0.93, 95% CI=0.87-0.99) were associated with lower risk of hospitalization, while greater numbers of diseases (HR=1.11, 95% CI=1.03-1.20) and negative life events (HR=1.16, 95%  CI=1.00-1.34) were associated with increased risk of hospitalization.

    Discussion: Our results show that both personal and social factors were important for the risk of hospitalization. This might be used in future interventions for understanding health care utilization.

  • 259. Hallonsten, A L
    et al.
    Wendt, Lill-Kari
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Oral health.
    Mejàre, I
    Birkhed, D
    Håkansson, C
    Lindvall, A M
    Edwardsson, S
    Koch, G
    Dental caries and prolonged breast-feeding in 18-month-old Swedish children.1995In: International Journal of Paediatric Dentistry, ISSN 0960-7439, E-ISSN 1365-263X, Vol. 5, no 3, p. 149-155Article in journal (Refereed)
  • 260.
    Hamarashid, Helin
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Biomedical Platform.
    Detektion av skillnader i näthinnans celler mellan friska djur och djur med Retinitis Pigmentosa, obehandlade och behandlade med Fenretinide2015Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The retina is the thin membrane located at the back of the eye. It has a high metabolism because the photoreceptors must adapt to constant changes in light levels and are therefore sensitive to various disorders. Fenretinide is a medicine used in cancer treatment where a temporary night blindness has been observed and thoughts occurred if this favored the retinal cells or not. The purpose of the study was to detect different cells in the retina with immunohistochemical staining through their specific protein profiles and compare the differences between healthy animals and animals with Retinitis Pigmentosa, untreated and treated with Fenretinide. The method used was immunofluorescence staining on retinas and sections from rat (n=21) and mouse (n=7). The results obtained showed that there was exclusively a difference in the expression of the protein Chx-10 present in the bipolar cells. The difference was observed in RCS rats, in which the expression was reduced for those treated with Fenretinide. In conclusion further confirmation of the results by performing, among other, a Western Blot analysis to verify if the number of bipolar cells actually decreases with Fenretinide treatment or if the number of bipolar cells is the same but their ability to express the protein decreases is required.

  • 261. Hammarstrand, G
    et al.
    Berggren, U
    Hakeberg, Magnus
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Oral health.
    Psychophysiological therapy vs. hypnotherapy in the treatment of patients with dental phobia.1995In: European Journal of Oral Sciences, ISSN 0909-8836, E-ISSN 1600-0722, Vol. 103, no 6, p. 399-404Article in journal (Refereed)
  • 262.
    Hammerö, Amanda
    et al.
    Jönköping University, School of Health and Welfare, HHJ, Dep. of Natural Science and Biomedicine.
    Morberg, Elinore
    Jönköping University, School of Health and Welfare, HHJ, Dep. of Natural Science and Biomedicine.
    Investigation of radiation doses in conjunction with CT thorax examinations performed in Vietnam: A phantom study2016Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 263.
    Hannu, Olof
    et al.
    Jönköping University, School of Health and Welfare, HHJ, Dep. of Natural Science and Biomedicine.
    Hagman, Leonardo
    Utvärdering av Copan EswabTM för viabilitet av bakterier2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Bacteria have always had a great influence on mankind. To diagnose any bacterial disease and treat it it’s necessary to identify the bacteria or any relevant attributes. Different types of specimen transport have been developed to keep the bacteria alive from sampling until the analysis is performed. The purpose of the study was to evaluate the viability of bacteria in the fluid-based media Copan EswabTM compared with charcoal medium (Copan swab). Bacteria included in the study were: Campylobacter jejuni, Streptococcus pneumoniae, Haemophilus influenzae, Niesseria gonorrhoeae and Fusobacterium nucleatum. The study also tried to compare how bacteria survived in Eswab which was refrigerated and in Eswab room temperature. Results for H. influenzae (n=9) and N. gonorrhoeae (n=9) showed that an equal amount or more of the bacteria survived in Eswab. More of F. nucleatum (n=9) survived in Copan swab (Copan swab sticks) for the first 28 hours, additionally they showed that the bacteria won’t survive more than 28 hours in room temperature. Regarding S. pneumoniae (n=9) and C. jejuni (n=9) both displayed unreliable results. Overall more measurements and additional studies are needed for more reliable results.

  • 264.
    Hansen, Johan
    et al.
    Jönköping University, School of Health and Welfare, HHJ, Dep. of Natural Science and Biomedicine.
    Holm, Tommy
    Jönköping University, School of Health and Welfare, HHJ, Dep. of Natural Science and Biomedicine.
    Deponering i hjärnvävnad med gadoliniumbaserade kontrastmedel: En systematisk litteraturstudie2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Bakgrund: I magnetisk resonanstomografi (MR) är kontrastmedel baserat på gadolinium vanligast. Den senaste forskningen har visat att gadolinium kan lagras långvarigt i hjärnvävnad. Röntgensjuksköterskan administrerar vanligtvis kontrastmedlet till patienten vid undersökningen. 

    Syfte: Syftet är att belysa deponering av gadolinium i hjärnvävnaderna nucleus dentatus och globus pallidus efter administrering av gadoliniumbaserade kontrastmedel samt eventuella risker till följd av deponeringen.

    Metod: Litteraturstudien inkluderar 16 vetenskapliga artiklar varav den äldsta artikeln är från 2014. Sökningen av artiklarna gjordes via Jönköpings högskolebibliotek och har kvalitetsgranskats av författarna.

    Resultat: Deponering i hjärnvävnad kunde påvisas bland linjära gadoliniumbaserade kontrastmedel. Liknande mätning med makrocykliska kontrastmedel gav ej samstämmiga resultat. Risker av deponeringen kunde ej påvisas.

    Slutsats: En litteraturstudie som belyser deponeringsrisker kring användandet av gadoliniumbaserade kontrastmedel. Verksamma röntgensjuksköterskor bör ha kunskap om dessa deponeringsrisker vid administrering av gadoliniumbaserat kontrastmedel.

  • 265. Haraldson, Torgny
    et al.
    Magnusson, Tomas
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine.
    Enkätundersökning: Vem bör ansvara för det bettfysiologiska specialistomhändertagandet?1987In: Tandläkartidningen, ISSN 0039-6982, Vol. 79, no 17, p. 881-886Article in journal (Other academic)
  • 266.
    Hassan, Hamda
    et al.
    Jönköping University, School of Health and Welfare, HHJ, Dep. of Natural Science and Biomedicine.
    Klos-Piontek, Magdalena
    Jönköping University, School of Health and Welfare, HHJ, Dep. of Natural Science and Biomedicine.
    JÄMFÖRELSE AV MANUELL- OCHAUTOMATISK MÄTNINGAV SLAGLÄNGDEN ÖVERVÄNSTRA KAMMARENS UTFLÖDESTRAKTI TVÅDIMENSIONELL EKOKARDIOGRAFI2016Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Tvådimensionell ekokardiografi som en icke-invasiv metod används bl.a. vid bedömning av systolisk vänsterkammarfunktion. Slagvolym (SV) är den mängd blod hjärtat pumpar ut under systole och används för vidareberäkningar av hjärtminutvolym (CO) och cardiac index (CI). Vänstra kammarens utflödestrakt (LVOT) anses vara det bästa området att beräkna SV. Då multipliceras LVOT-diameter och Velocity time integral (VTI)- ett mått på hur långt blodet skickas under systole. VTI mäts manuellt eller automatiskt utifrån dopplerkurvan som lagts i LVOT. Förutom SV, CO och CI används LVOT och VTI inom den kardiologiska diagnostiken vid utredningen av klaffsjukdomar, shuntar och hjärtsvikt.Syftet med studien var att jämföra om det fanns signifikant skillnad när VTI mättes manuellt och automatiskt.22 patienter deltog i denna studie och båda VTI-mätningar (den manuella och- automatiska) utfördes på varje patient. En jämförelse av båda mätningarna gjordes och vidare analyserades angående hur båda VTI påverkade slagvolymberäkningen.Resultatet visade att automatiska VTI gav högre värde än manuella VTI och resulterade med högre slagvolymvärden. Skillnaderna var signifikanta eftersom p-värdena var motsvarande 0,002 och 0,003. Metoderna hade dock en bra korrelation (r=0,950 för VTI, r=0,984 för SV).Vidare forskning behövs för att kunna avgöra om den manuella metoden kan ersättas med den automatiska.

  • 267. Hedlund, Elisabeth
    et al.
    Karlsson, Jan-Erik
    Starck, Sven-Åke
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine.
    Automatic and manual image fusion of In-pentetreotide SPECT and diagnostic CT in neuroendocrine tumor imaging: an evaluation2010In: Journal of Applied Clinical Medical Physics, ISSN 1526-9914, E-ISSN 1526-9914, Vol. 35, no 4, p. 223-228Article in journal (Refereed)
    Abstract [en]

    In the clinical diagnosis of neuroendocrine tumors (NET), the results of examinations, such as high-resolution computed tomography (CT) and single photon computerized tomography (SPECT), have conventionally been interpreted separately. The aim of the present study was to evaluate Hermes Multimodality™ 5.0 H Image Fusion software-based automatic and manual image fusion of SPECT and CT for the localization of NET lesions. Out of 34 NET patients who were examined by means of somatostatin receptor scintigraphy (SRS) with 111In- pentetreotide along with SPECT, 22 patients had a CT examination of the abdomen, which was used in the fusion analysis. SPECT and CT data were fused using software with a registration algorithm based on normalized mutual information. The criteria for acceptable fusion were established at a maximum cranial or caudal dislocation of 25 mm between the images and at a reasonable consensus (in order of less than 1 cm) between outline of the reference organs. The automatic fusion was acceptable in 13 of the 22 examinations, whereas 9 fusions were not. However all the 22 examinations were acceptable at the manual fusion. The result of automatic fusion was better when the slice thickness of 5 mm was applied at CT examination, when the number of slices was below 100 in CT data and when both examinations included uptakes of pathological lesions. Retrospective manual image fusion of SPECT and CT is a relatively inexpensive but reliable method to be used in NET imaging. Automatic image fusion with specified software of SPECT and CT acts better when the number of CT slices is reduced to the SPECT volume and when corresponding pathological lesions appear at both SPECT and CT examinations.

  • 268. Heikkila, Katriina
    et al.
    Nyberg, Solja T.
    Madsen, Ida E. H.
    de Vroome, Ernest
    Alfredsson, Lars
    Bjorner, Jacob J.
    Borritz, Marianne
    Burr, Hermann
    Erbel, Raimund
    Ferrie, Jane E.
    Fransson, Eleonor I.
    Jönköping University, School of Health and Welfare, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health and Welfare, HHJ. ADULT.
    Geuskens, Goedele A.
    Hooftman, Wendela E.
    Houtman, Irene L.
    Jöckel, Karl-Heinz
    Knutsson, Anders
    Koskenvuo, Markku
    Lunau, Thorsten
    Nielsen, Martin L.
    Nordin, Maria
    Oksanen, Tuula
    Pejtersen, Jan H.
    Pentti, Jaana
    Shipley, Martin J.
    Steptoe, Andrew
    Suominen, Sakari B.
    Theorell, Töres
    Vahtera, Jussi
    Westerholm, Peter J. M.
    Westerlund, Hugo
    Dragano, Nico
    Rugulies, Reiner
    Kawachi, Ichiro
    Batty, G. David
    Singh-Manoux, Archana
    Virtanen, Marianna
    Kivimäki, Mika
    Long working hours and cancer risk: a multi-cohort study2016In: British Journal of Cancer, ISSN 0007-0920, E-ISSN 1532-1827, Vol. 114, p. 813-818Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Working longer than the maximum recommended hours is associated with an increased risk of cardiovascular disease, but the relationship of excess working hours with incident cancer is unclear.

    METHODS: This multi-cohort study examined the association between working hours and cancer risk in 116 462 men and women who were free of cancer at baseline. Incident cancers were ascertained from national cancer, hospitalisation and death registers; weekly working hours were self-reported.

    RESULTS: During median follow-up of 10.8 years, 4371 participants developed cancer (n colorectal cancer: 393; n lung cancer: 247; n breast cancer: 833; and n prostate cancer: 534). We found no clear evidence for an association between working hours and the overall cancer risk. Working hours were also unrelated the risk of incident colorectal, lung or prostate cancers. Working ⩾55 h per week was associated with 1.60-fold (95% confidence interval 1.12-2.29) increase in female breast cancer risk independently of age, socioeconomic position, shift- and night-time work and lifestyle factors, but this observation may have been influenced by residual confounding from parity.

    CONCLUSIONS: Our findings suggest that working long hours is unrelated to the overall cancer risk or the risk of lung, colorectal or prostate cancers. The observed association with breast cancer would warrant further research.

  • 269.
    Heikkilä, K
    et al.
    Finnish Institute of Occupational Health, Helsinki, Finland.
    Madsen, I E H
    National Research Centre for the Working Environment, Copenhagen, Denmark.
    Nyberg, S T
    Finnish Institute of Occupational Health, Helsinki, Finland.
    Fransson, Eleonor
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. ADULT. Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Stress Research Institute, Stockholm University, Stockholm, Sweden.
    Westerlund, H
    Stress Research Institute, Stockholm University, Stockholm, Sweden.
    Westerholm, P. J. M.
    Occupational and Environmental Medicine, Uppsala University, Uppsala, Sweden.
    Virtanen, M.
    Finnish Institute of Occupational Health, Helsinki, Finland.
    Vahtera, J.
    Finnish Institute of Occupational Health, Turku, Finland; Department of Public Health, University of Turku, Turku, Finland.
    Väänänen, A.
    Finnish Institute of Occupational Health, Helsinki, Finland.
    Theorell, T.
    Stress Research Institute, Stockholm University, Stockholm, Sweden.
    Suominen, S. B.
    Department of Public Health, University of Turku, Turku, Finland; Folkhälsan Research Center, Helsinki, Finland; Nordic School of Public Health, Göteborg, Sweden .
    Shipley, M. J.
    Department of Epidemiology and Public Health, University College London, London, UK.
    Salo, P.
    Department of Public Health and Department of Psychology, University of Turku, Turku, Finland.
    Rugulies, R.
    National Research Centre for the Working Environment, Copenhagen, Denmark; Department of Public Health, Department of Psychology, University of Copenhagen, Copenhagen, Denmark.
    Pentti, J.
    Department of Public Health, University of Turku, Turku, Finland.
    Pejtersen, J. H.
    The Danish National Centre for Social Research, Copenhagen, Denmark.
    Oksanen, T.
    Finnish Institute of Occupational Health, Turku, Finland.
    Nordin, M.
    Department of Psychology, Umeå University, Umeå, Sweden.
    Nielsen, M. L.
    Department of Occupational and Environmental Medicine, Bispebjerg University Hospital, Copenhagen, Denmark.
    Kouvonen, A.
    School of Sociology, Social Policy & Social Work, Queen's University Belfast, Belfast, UK.
    Koskinen, A.
    Finnish Institute of Occupational Health, Helsinki, Finland.
    Koskenvuo, M.
    Department of Public Health, University of Helsinki, Helsinki, Finland.
    Knutsson, A.
    Department of Health Sciences, Mid Sweden University, Sundsvall, Sweden.
    Ferrie, J. E.
    Occupational and Environmental Medicine, Uppsala University, Uppsala, Sweden; Social and Community Medicine, University of Bristol, Bristol, UK.
    Dragano, N.
    Institute for Medical Sociology, Medical Faculty, University of Düsseldorf, Düsseldorf, Germany.
    Burr, H.
    Federal Institute for Occupational Safety and Health (BAuA), Berlin, Germany.
    Borritz, M.
    Department of Occupational and Environmental Medicine, Bispebjerg University Hospital, Copenhagen, Denmark.
    Bjorner, J. B.
    National Research Centre for the Working Environment, Copenhagen, Denmark.
    Alfredsson, L.
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
    Batty, G. D.
    Department of Epidemiology and Public Health, University College London, London, UK; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK .
    Singh-Manoux, A.
    Department of Epidemiology and Public Health, University College London, London, UK; Inserm U1018, Centre for Research in Epidemiology and Population Health, Villejuif, France.
    Kivimäki, M.
    Finnish Institute of Occupational Health, Helsinki, Finland; Department of Epidemiology and Public Health, University College London, London, UK.
    Job strain and the risk of severe asthma exacerbations: a meta-analysis of individual-participant data from 100 000 European men and women2014In: Allergy. European Journal of Allergy and Clinical Immunology, ISSN 0105-4538, E-ISSN 1398-9995, Vol. 69, no 6, p. 775-783Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Many patients and healthcare professionals believe that work-related psychosocial stress, such as job strain, can make asthma worse, but this is not corroborated by empirical evidence. We investigated the associations between job strain and the incidence of severe asthma exacerbations in working-age European men and women.

    METHODS: We analysed individual-level data, collected between 1985 and 2010, from 102 175 working-age men and women in 11 prospective European studies. Job strain (a combination of high demands and low control at work) was self-reported at baseline. Incident severe asthma exacerbations were ascertained from national hospitalization and death registries. Associations between job strain and asthma exacerbations were modelled using Cox regression and the study-specific findings combined using random-effects meta-analyses.

    RESULTS: During a median follow-up of 10 years, 1 109 individuals experienced a severe asthma exacerbation (430 with asthma as the primary diagnostic code). In the age- and sex-adjusted analyses, job strain was associated with an increased risk of severe asthma exacerbations defined using the primary diagnostic code (hazard ratio, HR: 1.27, 95% confidence interval, CI: 1.00, 1.61). This association attenuated towards the null after adjustment for potential confounders (HR: 1.22, 95% CI: 0.96, 1.55). No association was observed in the analyses with asthma defined using any diagnostic code (HR: 1.01, 95% CI: 0.86, 1.19).

    CONCLUSIONS: Our findings suggest that job strain is probably not an important risk factor for severe asthma exacerbations leading to hospitalization or death.

  • 270.
    Heikkilä, Katriina
    et al.
    Finnish Institute of Occupational Health, Helsinki.
    Fransson, Eleonor
    Jönköping University, School of Health and Welfare, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health and Welfare, HHJ. ADULT.
    Nyberg, Solja
    Finnish Institute of Occupational Health, Helsinki.
    Zins, Marie
    Westerlund, Hugo
    Westerholm, Peter
    Virtanen, Marianna
    Vahtera, Jussi
    Theorell, Töres
    Suominen, Sakari
    Steptoe, Andrew
    Salo, Paula
    Pentti, Jaana
    Oksanen, Tuula
    Nordin, Maria
    Marmot, Michael
    Lunau, Thorsten
    Knutsson, Anders
    Ladwig, Karl-Heinz
    Kittel, France
    Koskenvuo, Markku
    Jöckel, Karl-Heinz
    Goldberg, Marcel
    Erbel, Raimund
    Dragano, Nico
    DeBacquer, Dirk
    Clays, Els
    Casini, Annalisa
    Alfredsson, Lars
    Ferrie, Jane
    Singh-Manoux, Archana
    Batty, David
    Kivimäki, Mika
    Job strain and health-related lifestyle: Findings from an individual-participant meta-analysis of 118 000 working adults2013In: American Journal of Public Health, ISSN 0090-0036, E-ISSN 1541-0048, Vol. 103, no 11, p. 2090-2097Article in journal (Refereed)
    Abstract [en]

    Objectives. We examined the associations of job strain, an indicator of work-related stress, with overall unhealthy and healthy lifestyles.

    Methods. We conducted a meta-analysis of individual-level data from 11 European studies (cross-sectional data: n = 118 701; longitudinal data: n = 43 971). We analyzed job strain as a set of binary (job strain vs no job strain) and categorical (high job strain, active job, passive job, and low job strain) variables. Factors used to define healthy and unhealthy lifestyles were body mass index, smoking, alcohol intake, and leisure-time physical activity.

    Results. Individuals with job strain were more likely than those with no job strain to have 4 unhealthy lifestyle factors (odds ratio [OR] = 1.25; 95% confidence interval [CI] = 1.12, 1.39) and less likely to have 4 healthy lifestyle factors (OR = 0.89; 95% CI = 0.80, 0.99). The odds of adopting a healthy lifestyle during study follow-up were lower among individuals with high job strain than among those with low job strain (OR = 0.88; 95% CI = 0.81, 0.96).

    Conclusions. Work-related stress is associated with unhealthy lifestyles and the absence of stress is associated with healthy lifestyles, but longitudinal analyses suggest no straightforward cause–effect relationship between work-related stress and lifestyle.

  • 271.
    Heikkilä, Katriina
    et al.
    Finnish Institute of Occupational Health, Helsinki, Finland.
    Madsen, Ida E. H.
    National Research Centre for the Working Environment, Copenhagen, Denmark.
    Nyberg, Solja T.
    Finnish Institute of Occupational Health, Helsinki, Finland.
    Fransson, Eleonor
    Jönköping University, School of Health and Welfare, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health and Welfare, HHJ. ADULT.
    Ahola, Kirsi
    Finnish Institute of Occupational Health, Helsinki, Finland.
    Alfredsson, Lars
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
    Bjorner, Jakob B.
    National Research Centre for the Working Environment, Copenhagen, Denmark.
    Borritz, Marianne
    Department of Occupational and Environmental Medicine, Bispebjerg University Hospital, Copenhagen, Denmark.
    Burr, Hermann
    Federal Institute for Occupational Safety and Health (BAuA), Berlin, Germany.
    Dragano, Nico
    Institute for Medical Sociology, Medical Faculty, University of Düsseldorf, Düsseldorf, Germany.
    Ferrie, Jane E.
    School of Community and Social Medicine, University of Bristol, Bristol, United Kingdom.
    Knutsson, Anders
    Department of Health Sciences, Mid Sweden University, Sundsvall, Sweden.
    Koskenvuo, Markku
    Department of Public Health, University of Helsinki, Helsinki, Finland.
    Koskinen, Aki
    Finnish Institute of Occupational Health, Helsinki, Finland.
    Nielsen, Martin L.
    Department of Occupational and Environmental Medicine, Bispebjerg University Hospital, Copenhagen, Denmark.
    Nordin, Maria
    Department of Psychology, Umeå University, Umeå, Sweden.
    Pejtersen, Jan H.
    The Danish National Centre for Social Research, Copenhagen, Denmark.
    Pentti, Jaana
    Finnish Institute of Occupational Health, Helsinki, Tampere and Turku, Finland.
    Rugulies, Reiner
    National Research Centre for the Working Environment, Copenhagen, Denmark.
    Oksanen, Tuula
    Finnish Institute of Occupational Health, Helsinki, Tampere and Turku, Finland.
    Shipley, Martin J.
    Department of Epidemiology and Public Health, University College London, London, United Kingdom.
    Suominen, Sakari B.
    Folkhälsan Research Center, Helsinki, Finland.
    Theorell, Töres
    Stress Research Institute, Stockholm University, Stockholm, Sweden.
    Väänänen, Ari
    Finnish Institute of Occupational Health, Helsinki, Finland.
    Vahtera, Jussi
    Finnish Institute of Occupational Health, Helsinki, Tampere and Turku, Finland.
    Virtanen, Marianna
    Finnish Institute of Occupational Health, Helsinki, Finland.
    Westerlund, Hugo
    Stress Research Institute, Stockholm University, Stockholm, Sweden.
    Westerholm, Peter J. M.
    Occupational and Environmental Medicine, Uppsala University, Uppsala, Sweden.
    Batty, G. David
    Department of Epidemiology and Public Health, University College London, London, United Kingdom.
    Singh-Manoux, Archana
    Department of Epidemiology and Public Health, University College London, London, United Kingdom.
    Kivimäki, Mika
    Finnish Institute of Occupational Health, Helsinki, Finland.
    Job Strain and the Risk of Inflammatory Bowel Diseases: Individual-Participant Meta-Analysis of 95 000 Men and Women2014In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 9, no 2: e88711Article in journal (Refereed)
    Abstract [en]

    Background and aims: Many clinicians, patients and patient advocacy groups believe stress to have a causal role in inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis. However, this is not corroborated by clear epidemiological research evidence. We investigated the association between work-related stress and incident Crohn's disease and ulcerative colitis using individual-level data from 95 000 European adults.

    Methods: We conducted individual-participant data meta-analyses in a set of pooled data from 11 prospective European studies. All studies are a part of the IPD-Work Consortium. Work-related psychosocial stress was operationalised as job strain (a combination of high demands and low control at work) and was self-reported at baseline. Crohn's disease and ulcerative colitis were ascertained from national hospitalisation and drug reimbursement registers. The associations between job strain and inflammatory bowel disease outcomes were modelled using Cox proportional hazards regression. The study-specific results were combined in random effects meta-analyses.

    Results: Of the 95 379 participants who were free of inflammatory bowel disease at baseline, 111 men and women developed Crohn's disease and 414 developed ulcerative colitis during follow-up. Job strain at baseline was not associated with incident Crohn's disease (multivariable-adjusted random effects hazard ratio: 0.83, 95% confidence interval: 0.48, 1.43) or ulcerative colitis (hazard ratio: 1.06, 95% CI: 0.76, 1.48). There was negligible heterogeneity among the study-specific associations.

    Conclusions: Our findings suggest that job strain, an indicator of work-related stress, is not a major risk factor for Crohn's disease or ulcerative colitis.

  • 272. Heikkilä, Katriina
    et al.
    Madsen, Ida E H
    Nyberg, Solja T
    Fransson, Eleonor I
    Jönköping University, School of Health and Welfare, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health and Welfare, HHJ. ADULT.
    Ahola, Kirsi
    Alfredsson, Lars
    Bjorner, Jakob B
    Borritz, Marianne
    Burr, Hermann
    Knutsson, Anders
    Koskenvuo, Markku
    Koskinen, Aki
    Nielsen, Martin L
    Nordin, Maria
    Pahkin, Krista
    Pentti, Jaana
    Rugulies, Reiner
    Salo, Paula
    Shipley, Martin J
    Suominen, Sakari B
    Theorell, Töres
    Väänänen, Ari
    Vahtera, Jussi
    Virtanen, Marianna
    Westerholm, Peter J M
    Batty, G David
    Singh-Manoux, Archana
    Kivimäki, Mika
    Job strain and COPD exacerbations: an individual-participant meta-analysis2014In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 44, no 1, p. 247-251Article in journal (Refereed)
    Abstract [en]

    To the Editor:Chronic obstructive pulmonary disease (COPD) is a major cause of mortality and disability worldwide (1). The clinical course of COPD is characterised by exacerbations, which can be minor and manageable at home or in primary care, or severe, leading to hospitalisation or even death. Known causes of exacerbations include tobacco smoke, air pollution, dusts and fumes, and respiratory infections (1, 2). One less well understood risk factor is stress, which could plausibly lead to COPD exacerbations as it can trigger inflammation (3, 4) and is associated with increased smoking (5), which are both implicated in COPD pathology (2). Work is an important source of stress in the age groups in which COPD is typically diagnosed (1, 6). However, we are not aware of previous investigations of work-related stress and the risk of COPD exacerbations.In this study, we examined the associations between job strain (the most widely studied conceptualisation of work-related stress) and severe COPD exacerbations using individual-level data from 10 prospective cohort studies from the Individual Participant Data Meta-analysis in Working Populations (IPD-Work) Consortium (7). Job strain is defined as a combination of high demands (excessive amounts of work) and low control (having little influence on what tasks to.

  • 273. Heikkilä, Katriina
    et al.
    Nyberg, Solja
    Fransson, Eleonor
    Jönköping University, School of Health and Welfare, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health and Welfare, HHJ. ADULT. Jönköping University, School of Health and Welfare, HHJ. Ageing - living conditions and health.
    Alfredsson, Lars
    De Bacquer, Dirk
    Bjorner, Jakob
    Bonenfant, Sébastien
    Borritz, Marianne
    Burr, Hermann
    Clays, Els
    Casini, Annalisa
    Dragano, Nico
    Erbel, Raimund
    Geuskens, Goedele
    Goldberg, Marcel
    Hooftman, Wendela
    Houtman, Irene
    Joensuu, Matti
    Jöckel, Karl-Heinz
    Kittel, France
    Knutsson, Anders
    Koskenvuo, Markku
    Koskinen, Aki
    Kouvonen, Anne
    Leineweber, Constanze
    Lunau, Thorsten
    Madsen, Ida
    Magnusson Hanson, Linda
    Marmot, Michael
    Nielsen, Martin
    Nordin, Maria
    Pentti, Jaana
    Salo, Paula
    Rugulies, Reiner
    Steptoe, Andrew
    Siegrist, Johannes
    Suominen, Sakari
    Vahtera, Jussi
    Virtanen, Marianna
    Väänänen, Ari
    Westerholm, Peter
    Westerlund, Hugo
    Zins, Marie
    Theorell, Töres
    Hamer, Mark
    Ferrie, Jane
    Singh-Manoux, Archana
    Batty, David
    Kivimäki, Mika
    Job strain and alcohol intake: A collaborative meta-analysis of individual-participant data from 140 000 men and women2012In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 7, no 7, p. e40101-Article in journal (Refereed)
    Abstract [en]

    Background: The relationship between work-related stress and alcohol intake is uncertain. In order to add to the thus far inconsistent evidence from relatively small studies, we conducted individual-participant meta-analyses of the association between work-related stress (operationalised as self-reported job strain) and alcohol intake.

    Methodology and Principal Findings: We analysed cross-sectional data from 12 European studies (n = 142 140) and longitudinal data from four studies (n = 48 646). Job strain and alcohol intake were self-reported. Job strain was analysed as a binary variable (strain vs. no strain). Alcohol intake was harmonised into the following categories: none, moderate (women: 1–14, men: 1–21 drinks/week), intermediate (women: 15–20, men: 22–27 drinks/week) and heavy (women: >20, men: >27 drinks/week). Cross-sectional associations were modelled using logistic regression and the results pooled in random effects meta-analyses. Longitudinal associations were examined using mixed effects logistic and modified Poisson regression. Compared to moderate drinkers, non-drinkers and (random effects odds ratio (OR): 1.10, 95% CI: 1.05, 1.14) and heavy drinkers (OR: 1.12, 95% CI: 1.00, 1.26) had higher odds of job strain. Intermediate drinkers, on the other hand, had lower odds of job strain (OR: 0.92, 95% CI: 0.86, 0.99). We found no clear evidence for longitudinal associations between job strain and alcohol intake.

    Conclusions: Our findings suggest that compared to moderate drinkers, non-drinkers and heavy drinkers are more likely and intermediate drinkers less likely to report work-related stress.

  • 274. Heikkilä, Katriina
    et al.
    Nyberg, Solja T
    Fransson, Eleonor I
    Jönköping University, School of Health and Welfare, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health and Welfare, HHJ. ADULT. Jönköping University, School of Health and Welfare, HHJ. Ageing - living conditions and health.
    Alfredsson, Lars
    De Bacquer, Dirk
    Bjorner, Jakob B
    Bonenfant, Sébastien
    Borritz, Marianne
    Burr, Hermann
    Clays, Els
    Casini, Annalisa
    Dragano, Nico
    Erbel, Raimund
    Geuskens, Goedele A
    Goldberg, Marcel
    Hooftman, Wendela E
    Houtman, Irene L
    Joensuu, Matti
    Jöckel, Karl-Heinz
    Kittel, France
    Knutsson, Anders
    Koskenvuo, Markku
    Koskinen, Aki
    Kouvonen, Anne
    Leineweber, Constanze
    Lunau, Thorsten
    Madsen, Ida E H
    Magnusson Hanson, Linda L
    Marmot, Michael G
    Nielsen, Martin L
    Nordin, Maria
    Pentti, Jaana
    Salo, Paula
    Rugulies, Reiner
    Steptoe, Andrew
    Siegrist, Johannes
    Suominen, Sakari
    Vahtera, Jussi
    Virtanen, Marianna
    Väänänen, Ari
    Westerholm, Peter
    Westerlund, Hugo
    Zins, Marie
    Theorell, Töres
    Hamer, Mark
    Ferrie, Jane E
    Singh-Manoux, Archana
    Batty, G David
    Kivimäki, Mika
    Job strain and tobacco smoking: An individual-participant data meta-analysis of 166 130 adults in 15 European studies2012In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 7, no 7, p. e35463-Article in journal (Refereed)
    Abstract [en]

    Background: Tobacco smoking is a major contributor to the public health burden and healthcare costs worldwide, but the determinants of smoking behaviours are poorly understood. We conducted a large individual-participant meta-analysis to examine the extent to which work-related stress, operationalised as job strain, is associated with tobacco smoking in working adults.

    Methodology and Principal Findings: We analysed cross-sectional data from 15 European studies comprising 166 130 participants. Longitudinal data from six studies were used. Job strain and smoking were self-reported. Smoking was harmonised into three categories never, ex- and current. We modelled the cross-sectional associations using logistic regression and the results pooled in random effects meta-analyses. Mixed effects logistic regression was used to examine longitudinal associations. Of the 166 130 participants, 17% reported job strain, 42% were never smokers, 33% ex-smokers and 25% current smokers. In the analyses of the cross-sectional data, current smokers had higher odds of job strain than never-smokers (age, sex and socioeconomic position-adjusted odds ratio: 1.11, 95% confidence interval: 1.03, 1.18). Current smokers with job strain smoked, on average, three cigarettes per week more than current smokers without job strain. In the analyses of longitudinal data (1 to 9 years of follow-up), there was no clear evidence for longitudinal associations between job strain and taking up or quitting smoking.

    Conclusions: Our findings show that smokers are slightly more likely than non-smokers to report work-related stress. In addition, smokers who reported work stress smoked, on average, slightly more cigarettes than stress-free smokers.

  • 275. Heikkilä, Katriina
    et al.
    Nyberg, Solja
    Theorell, Töres
    Fransson, Eleonor
    Jönköping University, School of Health and Welfare, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health and Welfare, HHJ. ADULT.
    Alfredsson, Lars
    Bjorner, Jakob
    Bonenfant, Sébastien
    Borritz, Marianne
    Bouillon, Kim
    Burr, Hermann
    Dragano, Nico
    Geuskens, Goedele
    Goldberg, Marcel
    Hamer, Mark
    Hooftman, Wendela
    Houtman, Irene
    Joensuu, Matti
    Knutsson, Anders
    Koskenvuo, Markku
    Koskinen, Aki
    Kouvonen, Anne
    Madsen, Ida
    Magnusson Hanson, Linda
    Marmot, Michael
    Nielsen, Martin
    Nordin, Maria
    Oksanen, Tuula
    Pentti, Jaana
    Salo, Paula
    Rugulies, Reiner
    Steptoe, Andrew
    Suominen, Sakari
    Vahtera, Jussi
    Virtanen, Marianna
    Väänänen, Ari
    Westerholm, Peter
    Westerlund, Hugo
    Zins, Marie
    Ferrie, Jane
    Singh-Manoux, Archana
    Batty, David
    Kivimäki, Mika
    Work stress and risk of cancer: meta-analysis of 5700 incident cancer events in 116 000 European men and women2013In: BMJ. British Medical Journal, E-ISSN 1756-1833, Vol. 345, no f165Article in journal (Refereed)
    Abstract [en]

    Objective To investigate whether work related stress, measured and defined as job strain, is associated with the overall risk of cancer and the risk of colorectal, lung, breast, or prostate cancers.

    Design Meta-analysis of pooled prospective individual participant data from 12 European cohort studies including 116 056 men and women aged 17-70 who were free from cancer at study baseline and were followed-up for a median of 12 years. Work stress was measured and defined as job strain, which was self reported at baseline. Incident cancers (all n=5765, colorectal cancer n=522, lung cancer n=374, breast cancer n=1010, prostate cancer n=865) were ascertained from cancer, hospital admission, and death registers. Data were analysed in each study with Cox regression and the study specific estimates pooled in meta-analyses. Models were adjusted for age, sex, socioeconomic position, body mass index (BMI), smoking, and alcohol intake

    Results A harmonised measure of work stress, high job strain, was not associated with overall risk of cancer (hazard ratio 0.97, 95% confidence interval 0.90 to 1.04) in the multivariable adjusted analyses. Similarly, no association was observed between job strain and the risk of colorectal (1.16, 0.90 to 1.48), lung (1.17, 0.88 to 1.54), breast (0.97, 0.82 to 1.14), or prostate (0.86, 0.68 to 1.09) cancers. There was no clear evidence for an association between the categories of job strain and the risk of cancer.

    Conclusions These findings suggest that work related stress, measured and defined as job strain, at baseline is unlikely to be an important risk factor for colorectal, lung, breast, or prostate cancers.

  • 276. Hellqvist, L
    et al.
    Rolandsson, M
    Birkhed, D
    Hugoson, Anders
    Jönköping University, School of Health and Welfare, HHJ. Oral health. Jönköping University, School of Health and Welfare, HHJ, Dep. of Natural Science and Biomedicine.
    Tobacco use in relation to socioeconomic factors and dental care habits among Swedish individuals 15-70 years of age, 1983-20032009In: International Journal of Dental Hygiene, ISSN 1601-5029, E-ISSN 1601-5037, Vol. 7, no 1, p. 62-70Article in journal (Refereed)
  • 277.
    Hergens, Maria-Pia
    et al.
    Department of Communicable Disease Control, Stockholm County Council, Stockholm, Sweden.
    Galanti, Rosaria
    Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.
    Hansson, Jenny
    Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.
    Fredlund, Peeter
    Centre for Epidemiology and Community Medicine, Stockholm County Council, Stockholm, Sweden.
    Ahlbom, Anders
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
    Alfredsson, Lars
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
    Bellocco, Rino
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden and Department of Statistics, University of Milano-Bicocca, Milano, Italy.
    Eriksson, Marie
    Department of Statistics, Umeå University, Umeå, Sweden.
    Fransson, Eleonor I
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. ADULT. Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden and School of Health Science, Jönköping University, Jönköping, Sweden.
    Hallqvist, Johan
    Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.
    Jansson, Jan-Håkan
    Department of Medicine, Umeå University, Umeå, Sweden.
    Knutsson, Anders
    Department of Health Sciences, Mid Sweden University, Sundsvall, Sweden.
    Pedersen, Nancy
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
    Lagerros, Ylva Trolle
    Unit of Clinical Epidemiology, Dept. of Medicine, Karolinska Institutet, Stockholm, Sweden.
    Ostergren, Per-Olof
    Social Medicine and Global Health, Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden.
    Magnusson, Cecilia
    Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.
    Use of Scandinavian Moist Smokeless Tobacco (Snus) and the Risk of Atrial Fibrillation2014In: Epidemiology, ISSN 1044-3983, E-ISSN 1531-5487, Vol. 25, no 6, p. 872-876Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Snus is a smokeless tobacco product, widely used among Swedish men and increasingly so elsewhere. There is debate as to whether snus is an acceptable "harm-reduction" tobacco product. Since snus use delivers a dose of nicotine equivalent to cigarettes, and has been implicated in cardiac arrhythmia because of associations with sudden cardiovascular death, a relation with atrial fibrillation is plausible and important to investigate.

    METHODS:: To assess the relation between use of snus and risk of atrial fibrillation, we carried out a pooled analysis of 7 prospective Swedish cohort studies. In total, 274,882 men, recruited between 1978 and 2004, were followed via the National Patient Register for atrial fibrillation. Primary analyses were restricted to 127,907 never-smokers. Relative risks were estimated using Cox proportional hazard regression.

    RESULTS:: The prevalence of snus use was 25% among never-smokers. During follow-up, 3,069 cases of atrial fibrillation were identified. The pooled relative risk of atrial fibrillation was 1.07 (95% confidence interval = 0.97-1.19) in current snus users, compared with nonusers.

    CONCLUSION:: Findings from this large national pooling project indicate that snus use is unlikely to confer any important increase in risk of atrial fibrillation.

  • 278.
    Hermansson, Regina
    et al.
    Jönköping University, School of Health and Welfare, HHJ, Dep. of Natural Science and Biomedicine.
    Jalmgren, Maria
    Jönköping University, School of Health and Welfare, HHJ, Dep. of Natural Science and Biomedicine.
    Sena komplikationer efter percutan transluminal angioplastik i nedre extremiteter: En litteraturstudie2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Background: The purpose of percutanous transluminal angioplasty (PTA) is to treat patients with symptoms and discomfort because of stenosis and occlusions in the arteries caused by atherosclerosis. This is done by dilatation of the vessel diameter and sometimes placing a stent to maintain the patency of the artery. Working as a radiographer includes meeting patients before, during and after PTA. Purpose: The purpose of this study is to illustrate the most common late complications that can occur after PTA. Method: This is a systematic literature study. The inclusion criteria for the articles were to follow a scientific structure, they had to be published between 2007 and 2018 and they had to be peer-reviewed and ethically reviewed. The databases used in this study were CINAHL and MEDLINE. Critical Appraisal Skills Programme was used. Result: 20 scientific articles were included in this study. All of them reported restenosis. Stent fractures occurred in 5 of 20 studies and amputation occurred in 14 of 20 studies. Conclusion: Restenosis was the most common late complication of PTA both with and without stent placement. More research is needed using drug-coated balloons and drug-coated stents to see if there are any beneficial effects.

  • 279. Hildebrand, C
    et al.
    Johansson, Carina S
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine.
    Nodal spacing in the developing, young adult and aging rat inferior alveolar nerve1991In: Developmental Brain Research, ISSN 0165-3806, E-ISSN 1872-6755, Vol. 64, no 1-2, p. 175-181Article in journal (Refereed)
  • 280. Hildebrand, C
    et al.
    Karlsson, Magnus
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine.
    Risling, M
    Ganglionic axons in motor roots and pia mater.1997In: Progress in Neurobiology, ISSN 0301-0082, E-ISSN 1873-5118, Vol. 51, no 2, p. 89-128Article in journal (Refereed)
  • 281. Hjorth, Maria
    et al.
    Axelsson, Stina
    Rydén, Anna
    Faresjö, Maria
    Jönköping University, School of Health and Welfare, HHJ. Biomedical Platform. Jönköping University, School of Health and Welfare, HHJ, Dep. of Natural Science and Biomedicine.
    Ludvigsson, Johnny
    Casas, Rosaura
    GAD-alum treatment induces GAD65-specific CD4+CD25highFOXP3+ cells in type 1 diabetic patients.2011In: Clinical Immunology, ISSN 1521-6616, E-ISSN 1521-7035, Vol. 138, no 1, p. 117-126Article in journal (Refereed)
    Abstract [en]

    Type 1 diabetes results from autoimmune destruction of insulin producing pancreatic β-cells. We have shown that treatment with alum-formulated glutamic acid decarboxylase 65 (GAD-alum) preserved residual insulin secretion and induced antigen-specific responses in children with recent onset type 1 diabetes. The aim of this study was to further investigate the immunomodulatory effect of GAD-alum, focusing on CD4+CD25high cells and their association to cytokine secretion. Samples obtained 21 and 30 months after the initial injection of GAD-alum or placebo were included in the present study. GAD65-stimulation enhanced the percentage of CD4+CD25highFOXP3+ cells, but reduced the percentage of CD4+CD25+ cells, in samples from the GAD-alum treated group. Further, the GAD65-induced secretion of IL-5, -10, and -13 correlated with the expression of CD4+CD25highFOXP3+ cells, but inversely with CD4+CD25+ cells. These new data suggest that GAD-alum treatment induced GAD65-specific T cells with regulatory features.

  • 282.
    Hugoson, Anders
    Jönköping University, School of Health and Welfare, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health and Welfare, HHJ. Oral health.
    Dental caries in relation to smoking and the use of Swedish snus: epidemiological studies covering 20 years (1983-2003)2012In: Acta Odontologica Scandinavica, ISSN 0001-6357, E-ISSN 1502-3850, Vol. 70, no 4, p. 289-296Article in journal (Refereed)
    Abstract [en]

    Objective. The aim of this study was to evaluate some intra-oral caries-associated variables and tobacco use on dental caries. Materials and methods. The participants were randomly recruited from three cross-sectional studies in Jönköping, Sweden, in 1983, 1993 and 2003. Each study consisted of 130 individuals in each of the 20, 30, 40, 50, 60 and 70-year age groups. Of these, 550, 552 and 523 dentate individuals attended respective year of examination. They were all examined both clinically and radiographically. A questionnaire was completed in conjunction with the examination. In the studies, 345 were smokers, 104 snus users and 1142 non-tobacco users, in total 1591 individuals. Results. In 1983 and 1993, there were no significant differences in mean DFS between non-users and smokers, but a statistically significantly higher mean DFS in comparison with snus users. In 2003, there was no statistically significant difference in mean DFS between the groups. Multiple regressions showed that, after adjusting for age, gender and socio-demographic variables, there was a statistically significant association between DFS and smoking in 1983 (smoking excluded in favour of lactobacilli when further analysed) and DFS and plaque index (PLI) in 1993. In 2003, there was no association, apart from buffer capacity (Power rising) between DFS and the examined intra-oral caries-associated variables and tobacco use. Conclusions. The results of these epidemiological studies, performed in 1993 and 2003, indicate that daily smoking or snus use does not increase the risk of dental caries.

  • 283.
    Hugoson, Anders
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine.
    Tandlöshet och tänder, munhygien, gingivit och parodontit2008Other (Other (popular science, discussion, etc.))
  • 284.
    Hugoson, Anders
    et al.
    Jönköping University, School of Health and Welfare, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health and Welfare, HHJ. Oral health.
    Hellqvist, Lena
    Boström, Anita
    Lingström, Peter
    Rolandsson, Margot
    Birkhed, Dowen
    Effect of nicotine-free and nicotine-containing snus on plaque pH in vivo2012In: Swedish Dental Journal, ISSN 0347-9994, Vol. 36, no 4, p. 187-194Article in journal (Refereed)
  • 285.
    Hugoson, Anders
    et al.
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Oral health.
    Koch , Göran
    Odontologiska Institutionen i Jönköping.
    Norderyd, Ola
    Odontologiska Institutionen.
    Sondell, Katarina
    Odontologiska Institutionen.
    Jönköpingsundersökningarna: unika och omtalade2008In: Tandläkartidningen, ISSN 0039-6982, Vol. 100, no 15, p. 50-54Article, review/survey (Other academic)
    Abstract [sv]

    I slutet av 1960-talet och början av 1970-talet skapade den odontologiska forskningen en bättre förståelse för de stora tandsjukdomarnas etiologi, prevention och behandling. Forsknignens framsteg ökade intresset för förebyggande åtgärder, bättre dignostik och förbättrad kvalitet i det rastaurativa arbetet. Samtidigt fanns en brist på både allmäntandläkare och specialister. Jönköpingsundersökningarna är i första hand exempel på tvärsnittsstudier som fångar upp de förändringar som sker inte bara inom tandvåden utan i hela samhället.

  • 286.
    Hugoson, Anders
    et al.
    Jönköping University, School of Health and Welfare, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health and Welfare, HHJ. Oral health.
    Rolandsson, Margot
    Periodontal disease in relation to smoking and the use of swedish snus: epidemiological studies covering 20 years (1983-2033)2011In: Journal of Clinical Periodontology, ISSN 0303-6979, E-ISSN 1600-051X, Vol. 38, no 9, p. 809-816Article in journal (Refereed)
    Abstract [en]

    ABSTRACT: Aim: The aim of the present study was to examine how deleterious current smoking and the use of Swedish moist snuff (snus) is for periodontal health compared with non-tobacco users. Materials and Methods: The studies comprised three epidemiological cross-sectional studies, in 1983, 1993 and 2003, of stratified random samples aged 20, 30, 40, 50, 60 and 70 years. The numbers of dentate participants were 550, 552 and 523, respectively. The participants were examined clinically and radiographically. Diagnostic criteria were the number of teeth, plaque, gingival status, probing pocket depth (PPD)4 mm, height of the alveolar bone level and classification by periodontal disease experience. In addition, participants were asked about their tobacco habits. Results: Multiple logistic regression shows, after adjusting for age, gender and sociodemographic variables, that relative to non-tobacco users, cigarette smokers had statistically significant less gingivitis, a higher frequency of PPD4 mm and a higher incidence of severe periodontitis. There was no significant association between gingivitis, frequency of PPD4 mm and periodontal disease experience and snus use. Conclusions: Cigarette smokers were found to have a statistically significant higher risk of severe periodontitis than non-tobacco users and users of snus. Using snus did not seem to be a risk factor for periodontitis.

  • 287. Hyland, Paul
    et al.
    Duggan, Orla
    Turbitt, Julie
    Coulter, James
    Wikby, Anders
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Johansson, Boo
    Tompa, Andrea
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health. Jönköping University, School of Health Science, HHJ. Biomedical Platform.
    Barnett, Christopher
    Barnett, Yvonne
    Nonagenarians from the Swedish NONA Immune Study have increased plasma antioxidant capacity and similar levels of DNA damage in peripheral blood mononuclear cells compared to younger control subjects2002In: Experimental Gerontology, ISSN 0531-5565, E-ISSN 1873-6815, Vol. 37, no 2-3, p. 465-473Article in journal (Refereed)
  • 288. Hägglin, C
    et al.
    Berggren, U
    Hakeberg, Magnus
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Oral health.
    Ahlqwist, M
    Dental anxiety among middle-aged and elderly women in Sweden: A study of oral state, utilisation of dental services and concomitant factors.1996In: Gerodontology, ISSN 0734-0664, E-ISSN 1741-2358, Vol. 13, no 1, p. 25-34Article in journal (Refereed)
  • 289. Hägglin, C
    et al.
    Berggren, U
    Hakeberg, Magnus
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Oral health.
    Hällstrom, T
    Bengtsson, C
    Variations in dental anxiety among middle-aged and elderly women in Sweden: a longitudinal study between 1968 and 1996.1999In: Journal of Dental Research, ISSN 0022-0345, E-ISSN 1544-0591, Vol. 78, no 10, p. 1655-1661Article in journal (Refereed)
  • 290. Hägglin, C
    et al.
    Hakeberg, Magnus
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Oral health.
    Ahlqwist, M
    Sullivan, M
    Berggren, U
    Factors associated with dental anxiety and attendance in middle-aged and elderly women.2000In: Community Dentistry and Oral Epidemiology, ISSN 0301-5661, E-ISSN 1600-0528, Vol. 28, no 6, p. 451-460Article in journal (Refereed)
  • 291. Hägglin, C
    et al.
    Hakeberg, Magnus
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Oral health.
    Hällström, T
    Berggren, U
    Larsson, L
    Waern, M
    Pálsson, S
    Skoog, I
    Dental anxiety in relation to mental health and personality factors: A longitudinal study of middle-aged and elderly women.2001In: European Journal of Oral Sciences, ISSN 0909-8836, E-ISSN 1600-0722, Vol. 109, no 1, p. 27-33Article in journal (Refereed)
  • 292. Hägglin, Catharina
    et al.
    Berggren, Ulf
    Hakeberg, Magnus
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Oral health.
    Edvardsson, Anna
    Eriksson, Marina
    Evaluation of a Swedish version of the OHIP-14 among patients in general and specialist dental care.2007In: Swedish Dental Journal, ISSN 0347-9994, Vol. 31, no 2, p. 91-101Article in journal (Refereed)
    Abstract [en]

    The aim of this study was to investigate the Swedish version of an oral health-related quality of life (OHRQL) instrument, the short form of the Oral Health Impact Profile (OHIP-14), and to assess OHRQL among patients in general dental care and specialist clinics (periodontics, TMD and implant dentistry) in Göteborg, Sweden. Consecutively selected patients were asked to answer the OHIP-14, the General Oral Health Assessment Index (GOHAI) and a questionnaire including socio-demographic, general health and oral health questions. 153 patients (50-89 years old) out of 237 (65%) returned the questionnaires. Cronbach's Alpha among the OHIP items was high (0.93) and the corrected item-scale correlation varied between 0.51 and 0.79. The correlation between the OHIP-14 score and the GOHAI was high (-0.83) indicating good criterion validity. The mean additive OHIP-14 score was 22.6 (SD = 10.5). Implant patients scored significantly higher than other patient groups with respect to missing teeth, dentures and mobile teeth. High scores were also associated with perceived poor general health and dissatisfaction with life-situation. The test-retest reliability was assessed in a separate sample (n = 47) and the correlation coefficient was 0.85. The Swedish version of OHIP-14 demonstrated good reliability and validity. The poorer OHRQL reported by the implant patients reflects the strong association found between OHIP score and dentures and missing teeth, while OHIP-14 did not show similar sensitivity to other impacts of oral disorders.

  • 293.
    Håkansson, Ida
    et al.
    Jönköping University, School of Health and Welfare, HHJ, Dep. of Natural Science and Biomedicine.
    Lundquist, Hans
    Jönköping University, School of Health and Welfare, HHJ, Dep. of Natural Science and Biomedicine.
    Bestämning och jämförelse av lägsta detektionsintervall för odling och qPCR vid analys av Staphylococcus aureus2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Hospital-acquired infections (HAI) are an increasing problem in health care facilities. In the neonatal intensive care unit at Länssjukhuset Ryhov in Jönköping, inconsistent cultivation results have been observed for suspected HAI caused by Staphylococcus aureus. To prevent HAI and to maintain patient safety, sensitive and reliable laboratory tests are essential. The aim of the study was to determine and compare the lowest range of detection for cultivation and qPCR with and without enrichment in MAMSA broth, for S. aureus. Serial dilutions of S. aureus were made, and the original concentration was determined through viable count. Cultivation on blood agar and qPCR with and without enrichment in MAMSA broth was performed. The results were used to determine a minimum detection range. For cultivation, a minimum detection range of 0,5–62 CFU/ml was determined and for qPCR a range of 6400–140 000 CFU/ml. For qPCR after enrichment in MAMSA broth, a lowest detection range of 0,6–140 CFU/ml was determined. For detection with cultivation single to tenths of CFU/ml were needed in the sample. For qPCR thousands to tenths of thousands of CFU/ml were needed. For qPCR with enrichment in MAMSA broth the detection range could be lowered to levels comparable with cultivation. For clinical application, further studies are needed with more bacterial species and replicates.

  • 294.
    Högberg, Gustav
    et al.
    Jönköping University, School of Health and Welfare, HHJ, Dep. of Natural Science and Biomedicine.
    Karlsson, Pontus
    Jönköping University, School of Health and Welfare, HHJ, Dep. of Natural Science and Biomedicine.
    Detektion och kvantifiering av två olika isoformer av PDIA3 i prostatacancerceller2019Independent thesis Basic level (professional degree), 180 HE creditsStudent thesis
    Abstract [en]

    There is a need for more specific biomarkers related to prostate cancer, which would increase treatment options. Different isoforms of protein disulfide isomerase family A, member 3 (PDIA3) are associated with prostate cancer and can potentially be used as biomarkers. The aims of this study were to detect, quantify and examine the gene expression of the protein coding isoform PDIA3-201 and a newly discovered isoform of PDIA3 (PDIA3-Novel) in prostate cancer cells in varying stages. The expression was analysed using droplet digital Polymerase Chain Reaction (ddPCR) in normal prostate cells and in prostate cancer cell lines (PNT2, DU145, PC3 and LNCaP). Variation within replicates and between different dilutions were observed. The ratio of concentrations between PDIA3-Novel and PDIA3-201 differed both within and between the cell lines. The expression of PDIA3-Novel was higher in PNT2 and PC3 compared to DU145. The expression of PDIA3-Novel was higher in the metastatic stage of prostate cancer (LNCaP), but the flaws in the study reduces the reliability of the results. The results of this study indicate that PDIA3-Novel can be used as a biomarker for prostate cancer and provide information beneficial for treatment. More experiments on a larger scale needs to be performed.

  • 295. Hörnquist, J O
    et al.
    Wikby, Anders
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Andersson, P O
    Dufva, A M
    Insulin-pen treatment, quality of life and metabolic control: retrospective intra-group evaluations.1990In: Diabetes Research and Clinical Practice, ISSN 0168-8227, E-ISSN 1872-8227, Vol. 10, no 3, p. 221-230Article in journal (Refereed)
  • 296. Hörnquist, J O
    et al.
    Wikby, Anders
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Hansson, B
    Andersson, P O
    Quality of life: status and change (QLsc) reliability, validity and sensitivity of a generic assessment approach tailored for diabetes.1993In: Quality of Life Research, ISSN 0962-9343, E-ISSN 1573-2649, Vol. 2, no 4, p. 263-279Article in journal (Refereed)
  • 297. Hörnqvist, J O
    et al.
    Wikby, Anders
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Stenström, Ulf
    Jönköping University, School of Health Science, HHJ, Dep. of Behavioural Science and Social Work. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Andersson, P O
    Change in quality of life along with type 1 diabetes.1995In: Diabetes Research and Clinical Practice, ISSN 0168-8227, E-ISSN 1872-8227, Vol. 28, no 1, p. 63-72Article in journal (Refereed)
  • 298. Hörnqvist, J O
    et al.
    Wikby, Anders
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Stenström, Ulf
    Jönköping University, School of Health Science, HHJ, Dep. of Behavioural Science and Social Work. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
    Andersson, P O
    Akerlind, I
    Type II diabetes and quality of life: a review of the literature.1995In: PharmacoEconomics (Auckland), ISSN 1170-7690, E-ISSN 1179-2027, Vol. 8, no Suppl 1, p. 12-16Article in journal (Refereed)
  • 299.
    Jacobsson, Brittmarie
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health Science, HHJ. Oral health.
    Karies och kariesassocierade faktorer bland svenska 15-åringar med invandrarbakgrund2004Report (Other academic)
    Abstract [en]

    Objectives: The aim of the present study was to evaluate the prevalence of caries and caries associated variables in 15-year-olds with a foreign background in relation to Swedish 15-year-olds and to examine differences in the prevalence of caries in immigrant adolescents according to their length of residence in Sweden. Methods: All 15-year-old adolescents (n=143) at one public school in the city of Jönköping, Sweden, were asked to participate in the study. The adolescents were divided into two groups according to their background: immigrants and non-immigrants. The final study cohort comprised 117 adolescents: 51 immigrants and 66 non-immigrants. All participants were interviewed individually in a structed interview on background data, diet, oral hygiene habits and fluor exposure. Data on caries prevalence were extracted from the dental records of the examination made when the participants were 15 years old. Results: Immigrant adolescents had significantly more surfaces affected by enamel and dentine caries than non-immigrants, but the proportions of immigrants and non-immigrants who had symptoms of enamel or dentine caries were equal. Adolescents born in Sweden of immigrant parents or who had arrived before 1 year of age had caries prevalence similar to those of non-immigrant adolescents, whereas children who had immigrated to Sweden after seven years of age had a caries prevalence that was 2–3 times higher. Among immigrant adolescents, compared with non-immigrants, a lower proportion ate breakfast regularly and had a higher intake of snack products, and sucrose intake was positively correlated with caries prevalence among immigrants. There were no statistically significant differences in toothbrushing or flossing frequency or use of fluorides between immigrants and non-immigrants, but immigrant adolescents who brushed their teeth only once a day had more than twice as many proximal surfaces affected by caries as immigrants who brushed twice a day. Conclusion: Caries prevalence is higher in immigrant than in Swedish adolescents, especially in adolescents who immigrated to Sweden. After seven years of age. As caries was mainly restricted to the enamel. Immigrant adolescents had on average more caries associated factors than non-immigrants.

  • 300.
    Jacobsson, Brittmarie
    Jönköping University, School of Health Science, HHJ, Dep. of Natural Science and Biomedicine.
    Karies och Kariesassocierade faktorer hos 15-åringar med respektive utan invandrarbakgrund2004In: Nationell tandhygienistkonferens, 2004Conference paper (Refereed)
    Abstract [en]

    Abstract

    Objectives: The aim of the present study was to evaluate the prevalence of caries and caries associated variables in 15-year-olds with a foreign background in relation to Swedish 15-year-olds and to examine differences in the prevalence of caries in immigrant adolescents according to their length of residence in Sweden. Methods: All 15-year-old adolescents (n=143) at one public school in the city of Jönköping, Sweden, were asked to participate in the study. The adolescents were divided into two groups according to their background: immigrants and non-immigrants. The final study cohort comprised 117 adolescents: 51 immigrants and 66 non-immigrants. All participants were interviewed individually in a structed interview on background data, diet, oral hygiene habits and fluor exposure. Data on caries prevalence were extracted from the dental records of the examination made when the participants were 15 years old. Results: Immigrant adolescents had significantly more surfaces affected by enamel and dentine caries than non-immigrants, but the proportions of immigrants and non-immigrants who had symptoms of enamel or dentine caries were equal. Adolescents born in Sweden of immigrant parents or who had arrived before 1 year of age had caries prevalence similar to those of non-immigrant adolescents, whereas children who had immigrated to Sweden after seven years of age had a caries prevalence that was 2–3 times higher. Among immigrant adolescents, compared with non-immigrants, a lower proportion ate breakfast regularly and had a higher intake of snack products, and sucrose intake was positively correlated with caries prevalence among immigrants. There were no statistically significant differences in toothbrushing or flossing frequency or use of fluorides between immigrants and non-immigrants, but immigrant adolescents who brushed their teeth only once a day had more than twice as many proximal surfaces affected by caries as immigrants who brushed twice a day. Conclusion: Caries prevalence is higher in immigrant than in Swedish adolescents, especially in adolescents who immigrated to Sweden. After seven years of age. As caries was mainly restricted to the enamel. Immigrant adolescents had on average more caries associated factors than non-immigrants.

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