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  • 24201. Aldrin, Viktor
    et al.
    Holmgren, Anders
    Religionskunskap 1 för gymnasiet: ett digitalt läromedel2016Other (Refereed)
  • 24202.
    Aldrin, Viktor
    et al.
    University of Borås, Faculty of Librarianship, Information, Education and IT.
    Homgren, Anders
    Religionskunskap 1: Ett digitalt läromedel för gymnasiet2016Other (Refereed)
  • 24203.
    Aldrin, Viktor
    et al.
    Göteborgs universitet, Göteborg, Sverige.
    Keller, Christina
    Jönköping International Business School, Jönköping, Sweden.
    Kursguider, kursinstruktion och kursbeskrivning: Ett rundabordssamtal om kursguidepraktiker i högre utbildning2012Conference paper (Refereed)
    Abstract [sv]

    Vad ska en kursguide eller kurs-PM innehålla? Hur bör ett sådant dokument struktureras? Kursguider har som instruktionsdokument kommit att bli allt mer viktiga som dokument i undervisning på universitet och högskolor och utvecklats till att bli ett semiofficiellt dokument mellan kursplanernas formella nivå och undervisningens mer informella nivå (jfr Robinson 2011, Rowan & Correnti 2009). Ett exempel på detta är att betygskriterier tenderar att flyttas från kursplaner till kursguider. Som område ligger kursuidepraktiker nära den utveckling som sker inom kursplaneområdet och har i likhet med denna ett tydligt fokus på Constructive Alignment eftersom mål i kursplanen förklaras och konkretiseras i studieguiden (Martone & Sireci 2009). Utvecklingen av kursguider måste därför ha ett tydligt kvalitetsperspektiv med goda möjligheter till transparens och granskning (Porter 2002). En annan central aspekt av kursguidepraktiker är de sätt på vilket IKT kommit att påverka utvecklingen av kursguider. På vilka sätt kan lärplattformar och digitala medier användas? Digitala tekniker ger idag möjlighet att gå bortom ett papperstänk vad gäller instruktioner med ett enkelriktat budskap till att istället utgöra grund för interaktivitet och medskapande mellan lärare och student. Kursens gång kan därmed påverka utformningen av kursguiden som alltså blir både kommunikation, instruktion och dokumentation kring kursens mål och genomförande. Kursguider som forskningsområde är ett område med omfattande forskning vad gäller kursplanekonstruktion och instruktionsdesign (för en forskningsöversikt, se Roher & Pashler 2010), men med i stort sett obefintlig forskning om dess praktiker.

    Rundabordssamtalet kommer att ske i form av ett samtal mellan högskolepedagoger från västsvenska högre lärosäten. Målgruppen för rundabordssamtalet är dels pedagogiska ledare och dels undervisande lärare. Rundabordssamtalet är ett led i projektet Bättre Studieguider på Enheten för pedagogisk utveckling och interaktivt lärande (PIL) vid Göteborg universitet och det utbyte som påbörjats mellan västsvenska universitet och högskolor kring erfarenheter och idéer om kursguidepraktiker.

    Martone, A. & Sireci, S. G. (2009) Evaluating Alignment Between Curriculium, Assessment, and Instruction. Review of Educational Research 79(4), s. 1332–1361.

    Porter, A. C. (2002) Measuring the Content of Instruction: Uses in Research and Practice. Educational Researcher 31(7), s. 3­–14.

    Robinson, G. (2011) Designing Effective Instruction. Hoboken, NJ: Wiley.

    Roher, D. & Pashler, H. (2010) Recent Research on Human Learning Challenges Conventional Instructional Strategies. Educational Researcher 39(5), s. 406–412.

    Rowan, B. & Correnti, R. (2009) Studying Reading Instruction With Teacher Logs: Lessons From the Study of Instructional Improvement. Educational Researcher 38(2), s. 120–131.

  • 24204.
    Aldrin, Viktor
    et al.
    PIL-enheten, Göteborgs universitet.
    Keller, Christina
    Jönköping University, Jönköping International Business School, JIBS, Business Informatics.
    Kursguider, kursinstruktion och kursbeskrivning: Ett rundabordssamtal om kursguidepraktiker i högre utbildning2012Conference paper (Other academic)
    Abstract [sv]

    Vad ska en kursguide eller kurs-PM innehålla? Hur bör ett sådant dokument struktureras? Kursguider har som instruktionsdokument kommit att bli allt mer viktiga som dokument i undervisning på universitet och högskolor och utvecklats till att bli ett semiofficiellt dokument mellan kursplanernas formella nivå och undervisningens mer informella nivå (jfr Robinson 2011, Rowan & Correnti 2009). Ett exempel på detta är att betygskriterier tenderar att flyttas från kursplaner till kursguider. Som område ligger kursguidepraktiker nära den utveckling som sker inom kursplaneområdet och har i likhet med denna ett tydligt fokus på Constructive Alignment eftersom mål i kursplanen förklaras och konkretiseras i studieguiden (Martone & Sireci 2009). Utvecklingen av kursguider måste därför ha ett tydligt kvalitetsperspektiv med goda möjligheter till transparens och granskning (Porter 2002). En annan central aspekt av kursguidepraktiker är de sätt på vilket IKT kommit att påverka utvecklingen av kursguider. På vilka sätt kan lärplattformar och digitala medier användas? Digitala tekniker ger idag möjlighet att gå bortom ett papperstänk vad gäller instruktioner med ett enkelriktat budskap till att istället utgöra grund för interaktivitet och medskapande mellan lärare och student. Kursens gång kan därmed påverka utformningen av kursguiden som alltså blir både kommunikation, instruktion och dokumentation kring kursens mål och genomförande. Kursguider som forskningsområde är ett område med omfattande forskning vad gäller kursplanekonstruktion och instruktionsdesign (för en forskningsöversikt, se Roher & Pashler 2010), men med i stort sett obefintlig forskning om dess praktiker.

    Rundabordssamtalet kommer att ske i form av ett samtal mellan högskolepedagoger från västsvenska högre lärosäten. Målgruppen för rundabordssamtalet är dels pedagogiska ledare och dels undervisande lärare. Rundabordssamtalet är ett led i projektet Bättre Studieguider på Enheten för pedagogisk utveckling och interaktivt lärande (PIL) vid Göteborg universitet och det utbyte som påbörjats mellan västsvenska universitet och högskolor kring erfarenheter och idéer om kursguidepraktiker.

  • 24205.
    Aldrin, Viktor
    et al.
    University of Borås, Faculty of Librarianship, Information, Education and IT.
    Keller, Christina
    Jönköping International Business School, Jönköping, Sweden.
    Kursguider, kursinstruktion och kursbeskrivning: Ett rundabordssamtal om kursguidepraktiker i högre utbildning2012Conference paper (Other academic)
    Abstract [sv]

    Vad ska en kursguide eller kurs-PM innehålla? Hur bör ett sådant dokument struktureras? Kursguider har som instruktionsdokument kommit att bli allt mer viktiga som dokument i undervisning på universitet och högskolor och utvecklats till att bli ett semiofficiellt dokument mellan kursplanernas formella nivå och undervisningens mer informella nivå (jfr Robinson 2011, Rowan & Correnti 2009). Ett exempel på detta är att betygskriterier tenderar att flyttas från kursplaner till kursguider. Som område ligger kursuidepraktiker nära den utveckling som sker inom kursplaneområdet och har i likhet med denna ett tydligt fokus på Constructive Alignment eftersom mål i kursplanen förklaras och konkretiseras i studieguiden (Martone & Sireci 2009). Utvecklingen av kursguider måste därför ha ett tydligt kvalitetsperspektiv med goda möjligheter till transparens och granskning (Porter 2002). En annan central aspekt av kursguidepraktiker är de sätt på vilket IKT kommit att påverka utvecklingen av kursguider. På vilka sätt kan lärplattformar och digitala medier användas? Digitala tekniker ger idag möjlighet att gå bortom ett papperstänk vad gäller instruktioner med ett enkelriktat budskap till att istället utgöra grund för interaktivitet och medskapande mellan lärare och student. Kursens gång kan därmed påverka utformningen av kursguiden som alltså blir både kommunikation, instruktion och dokumentation kring kursens mål och genomförande. Kursguider som forskningsområde är ett område med omfattande forskning vad gäller kursplanekonstruktion och instruktionsdesign (för en forskningsöversikt, se Roher & Pashler 2010), men med i stort sett obefintlig forskning om dess praktiker.

    Rundabordssamtalet kommer att ske i form av ett samtal mellan högskolepedagoger från västsvenska högre lärosäten. Målgruppen för rundabordssamtalet är dels pedagogiska ledare och dels undervisande lärare. Rundabordssamtalet är ett led i projektet Bättre Studieguider på Enheten för pedagogisk utveckling och interaktivt lärande (PIL) vid Göteborg universitet och det utbyte som påbörjats mellan västsvenska universitet och högskolor kring erfarenheter och idéer om kursguidepraktiker.

    Martone, A. & Sireci, S. G. (2009) Evaluating Alignment Between Curriculium, Assessment, and Instruction. Review of Educational Research 79(4), s. 1332–1361.

    Porter, A. C. (2002) Measuring the Content of Instruction: Uses in Research and Practice. Educational Researcher 31(7), s. 3­–14.

    Robinson, G. (2011) Designing Effective Instruction. Hoboken, NJ: Wiley.

    Roher, D. & Pashler, H. (2010) Recent Research on Human Learning Challenges Conventional Instructional Strategies. Educational Researcher 39(5), s. 406–412.

    Rowan, B. & Correnti, R. (2009) Studying Reading Instruction With Teacher Logs: Lessons From the Study of Instructional Improvement. Educational Researcher 38(2), s. 120–131.

  • 24206. Aldrin, Viktor
    et al.
    Scheja, Max
    Institutionen för pedagogik och didaktik, Stockholms universitet, Stockholm, Sverige.
    Högskolepedagogik2014In: Nationalencyklopedin (NE.se) / [ed] Frans af Schmidt, Malmö: Nationalencyklopedin , 2014Chapter in book (Other (popular science, discussion, etc.))
  • 24207.
    Aldrin, Viktor
    et al.
    University of Borås, Faculty of Librarianship, Information, Education and IT.
    Scheja, Max
    Institutionen för pedagogik och didaktik, Stockholms universitet, Stockholm, Sverige.
    Högskolepedagogik2014In: Nationalencyklopedin (NE.se) :, Malmö: Nationalencyklopedin, 2014Chapter in book (Other academic)
  • 24208.
    Aldrin, Emilia
    Halmstad University, School of Education, Humanities and Social Science, Centrum för lärande, kultur och samhälle (CLKS).
    Användarnamn: Att namnge sig själv2019In: Sånt vi bara gör / [ed] Jenny Nilsson, Susanne Nylund Skog, Fredrik Skott, Stockholm: Carlsson Bokförlag, 2019, p. 148-150Chapter in book (Other (popular science, discussion, etc.))
  • 24209.
    Aldrin, Emilia
    Halmstad University, School of Education, Humanities and Social Science, Centrum för lärande, kultur och samhälle (CLKS).
    Naming, Identity, and Social Positioning in Teenagers’ Everyday Mobile Phone Interaction2019In: Names, ISSN 0027-7738, E-ISSN 1756-2279, Vol. 67, no 1, p. 30-39Article in journal (Refereed)
    Abstract [en]

    This article analyzes how a small group of Swedish teenagers handle onomastic choices of self- and other-referencing as part of their everyday mobile phone interaction. It further discusses how the teenagers explained their views regarding online names during interviews. The data are analyzed qualitatively using theories of identity and socialpositioning. Results show considerable differences between onomastic strategies used for self- and other-referencing. Self-referencing names were often practical, coherent, and authentic to the offline self, while other-referencing names were more flexible, creative, and socially positioned. However, the teenagers also displayed varying individual onomastic strategies and different folk-onomastic views on the function of usernames. © 2018 American Name Society

  • 24210.
    Aldrin-Kirk, Fredrick
    Karlstad University, Faculty of Health, Science and Technology (starting 2013).
    The Choice: An examination of young peoples commuting habits2013Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 24211.
    Aldrin, Viktor
    University of Borås, Faculty of Librarianship, Information, Education and IT.
    Ecclesiastical Educational re-orientations: The Church of Sweden as neglected divorcée from the nation state2019Conference paper (Refereed)
  • 24212.
    Aldsjö, Matilda
    et al.
    Stockholm University, Faculty of Humanities, Department of Media Studies, JMK.
    Ahmed, Nada
    Stockholm University, Faculty of Humanities, Department of Media Studies, JMK.
    Ett (o)frivilligt uppkopplat liv: En kvalitativ studie om individers sociala medier vanor.2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Skulle du kunna leva utan din mobiltelefon? Det var en av frågorna som ställdes när denna studie genomfördes. Syftet med detta examensarbete var att undersöka hur individer reflekterar över sin aktivitet på sociala medier och hur beroende individer är av att uppdatera sig. Detta gjordes i en kvalitativ forskningsstudie. Studien tittade närmare på sociala mediers inverkan på individers liv. I studien diskuterades vilka för- och nackdelar sociala medier har bidragit med, hur stort behov individer känner för att ständigt vara uppkopplade på sociala medier. Känslan ”fear of missing out” var signifikant för vad studiens respondenter känner när det kommer till uppdatering på sociala medier. Studien utgick från teorin uses and gratifications, utifrån den reflekterades det över hur den kan kopplas till dagens sociala medier-samhälle. För att ha möjligheten att se samband och diskutera ett fenomen användes fenomenologi som teoretiskt angreppssätt. Den generella slutsatsen blev att individernas huvudsakliga syfte för att använda sociala medier är för att kommunicera. Det kom inte direkt som en chockande nyhet. Studien bekräftar det tidigare studier sagt men klargör ännu tydligare att mobiltelefonen på många sätt den viktigaste pryl vi äger.

    Den här studien handlar om livet med mobiltelefonen fastklistrad i handen och varför vi är beroende av den. 

  • 24213.
    Aldskogius, Göran
    Umeå University, Faculty of Social Sciences, Centre for Regional Science (CERUM).
    Urban Policy in the Structural Policy of the European Union2000Report (Other academic)
    Abstract [en]

    The objective of this paper is to give a short overview of the actual discussionsand actions concerning urban policy in the European Union.No complete picture is given but this survey covers some importantactors and activities. The paper is concentrated on how urban policy isimplemented within the European Union structural policy during thelast ten years, and the period 2000–2006.

    A short overview is also given of discussions on urban policy in otherinternational organisations and in Sweden.

    At the end of the paper there is an attempt to summerize the effectsof the actual discussion about urban policy for the European Unionand for Sweden, in the framework of regional development and structuralpolicy.

  • 24214.
    Aldskogius, H
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
    Plasticity and rigidity in the nervous system: lessons from the spinal cord2000In: Advances in Structural Biology, JAI Press , 2000, Vol. 6, p. 187-Chapter in book (Other scientific)
  • 24215.
    Aldskogius, Hans
    Uppsala University.
    Från Chicago till Chisago.1997Report (Other scientific)
  • 24216.
    Aldskogius, Hans
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences.
    Geographical studies of vacation house settlement in Sweden1969Doctoral thesis, comprehensive summary (Other academic)
  • 24217.
    Aldskogius, Hans
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Social and Economic Geography.
    Gerd Enequist - professor i kulturgeografi 1949-1968: Föredrag och inlägg vid ett symposium i Uppsala 19992000Collection (editor) (Other academic)
  • 24218.
    Aldskogius, Hans
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Social Sciences, Department of Social and Economic Geography.
    Hur skriver vi vad för vem? Några reflektioner med anledning av enuppsats om "geografisk retorik"1996Conference paper (Other scientific)
  • 24219.
    Aldskogius, Hans
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Social Sciences, Department of Social and Economic Geography.
    Levnadsförhållanden och livsmönster1996In: Sveriges Nationalatlas: Sveriges geografi, Stockholm : Sveriges nationalatlas (SNA) , 1996, p. 134-167Chapter in book (Other scientific)
  • 24220.
    Aldskogius, Hans
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Social Sciences, Department of Social and Economic Geography.
    Minns du hur ödet oss förde tillhopa...1998In: Att famnaen ton: En kulturgeografisk minnesbok, Uppsala: Acta UniversitatisUpsaliensis , 1998, p. 141-156Chapter in book (Other scientific)
  • 24221.
    Aldskogius, Hans
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Social Sciences, Department of Social and Economic Geography.
    Några reflektioner kring den nomiska differentieringensNågra reflektioner kring den socio-ekonomiska differentieringensregionala mönster i Sverige1995Conference paper (Other scientific)
  • 24222.
    Aldskogius, Hans
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Social Sciences, Department of Social and Economic Geography.
    Recension av Ashworth, G. J. & P.J. Larkham (eds.): Building a newheritage. Tourism, culture and identity in the new Europe1996In: Geografiska Annaler, p. 121-122Article, book review (Other scientific)
  • 24223.
    Aldskogius, Hans
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Social Sciences, Department of Social and Economic Geography.
    Recension av Phillips, R.: Mapping men and empire. A geography ofadventure1998In: Geografiska Annaler, p. 126-127Article, book review (Other scientific)
  • 24224.
    Aldskogius, Hans
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences.
    Regional identitet och förändring i den regionala samverkans samhälle: föredrag och diskussioner vid Kulturgeografiska institutionens vid Uppsala universitet symposium 1-3 december 19771978Conference proceedings (editor) (Other academic)
  • 24225.
    Aldskogius, Hans
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Social Sciences, Department of Social and Economic Geography.
    Turism i Baskien1999In: Geografiska Notiser, no 1999:4, p. 246-251Article in journal (Other scientific)
  • 24226.
    Aldskogius, Hans
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences.
    Vacation House Settlement in the Siljan Region1967In: Geografiska Annaler. Series B, Human Geography, ISSN 0435-3684, E-ISSN 1468-0467, Vol. 49, no 2, p. 69-95Article in journal (Refereed)
  • 24227.
    Aldskogius, Hans
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Social Sciences, Department of Social and Economic Geography.
    Where sports and money meet. The economic geography of an ice hockeystadium1995In: The stadium and the city, Keele University Press , 1995, p. 255-275Chapter in book (Other scientific)
  • 24228.
    Aldskogius, Hans
    et al.
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Social Sciences, Department of Social and Economic Geography.
    Aldskogius, Maj
    Uppsalas första kvinnliga professor1995In: Universitetets bildvärld - strövtåg genom historien, konsten och samlingarna, Uppsala: Uppsala universitet , 1995, p. 182-183Chapter in book (Other scientific)
  • 24229.
    Aldskogius, Hans
    et al.
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Social Sciences, Department of Social and Economic Geography.
    Johansson, Bernth
    Kulturgeografin i kvarteret Lagerträdet : en dokumentation av en byggnad och institutionsmiljö i Uppsala åren 1958-19971998Book (Other scientific)
  • 24230.
    Aldskogius, Håkan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Regenerative neurobiology.
    Animal models of spinal cord repair2012Collection (editor) (Other academic)
  • 24231.
    Aldskogius, Håkan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neuroanatomy.
    Mechanisms and consequences of microglial responses to peripheral axotomy2011In: Frontiers in Bioscience, ISSN 1093-9946, E-ISSN 1093-4715, Vol. 3, p. 857-868Article in journal (Refereed)
    Abstract [en]

    Microglia respond rapidly to injury of peripheral nerve axons (axotomy). This response is integrated into the responses of the injured neurons, i.e. processes for neuron survival, axon regeneration and restoration of target contact. The microglial response is also integrated in changes in presynaptic terminals on axotomized motor or autonomic neurons and in changes in the central terminals of peripherally axotomized sensory neurons. Microglia also has an established role in interacting with astrocytes to shape their response to peripheral axotomy. Axotomy models in mice have demonstrated a role for microglia in regulating the entry of lymphocytes into motor nuclei or sensory areas following peripheral axotomy. Whether this is a universal component of peripheral nerve injury remains to be determined. Under certain circumstances, microglia activated by axotomy are major contributors to CNS pathology, e.g. in models of neuropathic pain. However, the general roles played by microglia after peripheral nerve injury are still incompletely understood. Early proposals that the microglial reaction to peripheral nerve injury is preparatory for the eventuality of neuron degeneration may still have relevance.

  • 24232.
    Aldskogius, Håkan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
    Microglia in neuroregeneration2001In: Microscopy research and technique (Print), ISSN 1059-910X, E-ISSN 1097-0029, Vol. 54, no 1, p. 40-46Article in journal (Refereed)
    Abstract [en]

    Microglia has the potential to produce and release a range of factors that directly and/or indirectly promote regeneration in the injured nervous system. The overwhelming evidence indicates, however, that this potential is generally not expressed in vivo. Activated microglia may enhance neuronal degeneration following axotomy, thereby counteracting functional recovery. Microglia does not seem to contribute significantly to axonal outgrowth after peripheral nerve injury, since this process proceeds uneventful even if perineuronal microglia is eliminated. The phagocytic phenotype of microglia is highly suppressed during Wallerian degeneration in the central nervous system. Therefore, microglia is incapable of rapid and efficient removal of myelin debris and its putative growth inhibitory components. In this way, microglia may contribute to regeneration failure in the central nervous system. Structural and temporal correlations are compatible with participation by perineuronal microglia in axotomy-induced shedding of presynaptic terminals, but direct evidence for such participation is lacking. Currently, the most promising case for a promoting effect on neural repair by activated microglia appears to be as a mediator of collateral sprouting, at least in certain brain areas. However, final proof for a critical role of microglia in these instances is still lacking. Results from in vitro studies demonstrate that microglia can develop a regeneration supportive phenotype. Altering the microglial involvement following neural injury from a typically passive or even counterproductive state and into a condition where these cells are actively supporting regeneration and plasticity is, therefore, an exciting challenge and probably a realistic goal.

  • 24233.
    Aldskogius, Håkan
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
    Mikroglia - nya målceller för neurologisk terapi2000In: Läkartidningen, Vol. 97, p. 3358-Article in journal (Other scientific)
  • 24234.
    Aldskogius, Håkan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
    Regulation of microglia: potential new drug targets in the CNS.2001In: Expert opinion on therapeutic targets, ISSN 1472-8222, E-ISSN 1744-7631, Vol. 5, no 6, p. 655-668Article in journal (Refereed)
    Abstract [en]

    Microglia respond to any disturbance in the CNS which poses a threat to physiological homeostasis. Although these responses are secondary, mainly to neuronal alterations, the way the microglial response evolves in many situations promotes further damage to the CNS. The list of clinical conditions in which this situation is a major problem is continuously growing and includes neurodegenerative diseases, stroke, trauma, demyelinating disorders and neuropathic pain. The significance of microglia for the pathogenesis of neurological and neuropsychiatric conditions has led to a rapidly expanding search for therapeutic possibilities to regulate microglial activity. As will be clear from this review, treatments which are currently available appear to offer some positive effects but are still far from satisfactory. A major challenge is to understand the mechanisms that determine whether activated microglia will develop into a cytotoxic or a cytoprotective component.

  • 24235.
    Aldskogius, Håkan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience. neuroanatomi.
    Repairing CNS myelin: astrocytes have to do their jobs2005In: Experimental Neurology, ISSN 0014-4886, E-ISSN 1090-2430, Vol. 192, no 1, p. 7-10Article in journal (Refereed)
  • 24236.
    Aldskogius, Håkan
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neuroanatomy.
    Berens, Christian
    Kanaykina, Nadegda
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neuroanatomy.
    Liakhovitskaia, Anna
    Medvinsky, Alexander
    Sandelin, Martin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neuroanatomy.
    Schreiner, Silke
    Wegner, Michael
    Hjerling-Leffler, Jens
    Kozlova, Elena
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neuroanatomy.
    Regulation of boundary cap neural crest stem cell differentiation after transplantation2009In: Stem Cells, ISSN 1066-5099, E-ISSN 1549-4918, Vol. 27, no 7, p. 1592-1603Article in journal (Refereed)
    Abstract [en]

    Success of cell replacement therapies for neurological disorders will dependlargely on the optimization of strategies to enhance viability and control thedevelopmental fate of stem cells after transplantation. Once transplanted,stem/progenitor cells display a tendency to maintain an undifferentiatedphenotype or differentiate into inappropriate cell types. Gain and loss offunction experiments have revealed key transcription factors which drivedifferentiation of immature stem/progenitor cells toward more mature stages andeventually to full differentiation. An attractive course of action to promotesurvival and direct the differentiation of transplanted stem cells to a specific cell type would therefore be to force expression of regulatory differentiationmolecules in already transplanted stem cells, using inducible gene expressionsystems which can be controlled from the outside. Here, we explore thishypothesis by employing a tetracycline gene regulating system (Tet-On) to drivethe differentiation of boundary cap neural crest stem cells (bNCSCs) toward asensory neuron fate after transplantation. We induced the expression of the keytranscription factor Runx1 in Sox10-expressing bNCSCs. Forced expression of Runx1strongly increased transplant survival in the enriched neurotrophic environmentof the dorsal root ganglion cavity, and was sufficient to guide differentiationof bNCSCs toward a nonpeptidergic nociceptive sensory neuron phenotype both invitro and in vivo after transplantation. These findings suggest that exogenousactivation of transcription factors expression after transplantation instem/progenitor cell grafts can be a constructive approach to control theirsurvival as well as their differentiation to the desired type of cell and thatthe Tet-system is a useful tool to achieve this.

  • 24237. Aldskogius, Håkan
    et al.
    Kozlova, Elena
    Dorsal root injury for the study of spinal cord injury repair2012In: Animal models of spinal cord repair, New York Heidelberg Dordrecht London: Humana Press, 2012, p. 109-129Chapter in book (Other academic)
    Abstract [en]

    Dorsal root injury provides opportunities for highly reproducible lesions and for detailed anatomical, physiological and behavioral outcome assessment with high precision and validity. Dorsal root injury models are used to several aspects of relevance to spinal cord injury repair: i) mechanisms of regeneration failure in the central nervous system and how to overcome it, ii) axon degeneration, as well as myelin degradation and elimination in the central nervous system - their roles and possible manipulations in spinal cord repair, iii) consequences in the spinal cord of mimicking human plexus injuries by dorsal root avulsion, including its effect on neuron survival, inflammatory processes and vascular dysfunction, and iv) therapeutic strategies which may be translated to the treatment of clinical plexus avulsion injuries. This chapter describes various dorsal root injury models, their relationship to basic and translational aspects of spinal cord injury repair, as well as basic experimental procedures associated with these models in rat and mouse.

  • 24238.
    Aldskogius, Håkan
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
    Kozlova, Elena N.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
    Central neuron-glial and glial-glial interactions following axon injury1998In: Progress in Neurobiology, ISSN 0301-0082, E-ISSN 1873-5118, Vol. 55, no 1, p. 1-26Article in journal (Refereed)
    Abstract [en]

    Axon injury rapidly activates microglial and astroglial cells close to the axotomized neurons. Following motor axon injury, astrocytes upregulate within hour(s) the gap junction protein connexin-43, and within one day glial fibrillary acidic protein (GFAP). Concomitantly, microglial cells proliferate and migrate towards the axotomized neuron perikarya. Analogous responses occur in central termination territories of peripherally injured sensory ganglion cells. The activated microglia express a number of inflammatory and immune mediators. When neuron degeneration occurs, microglia act as phagocytes. This is uncommon after peripheral nerve injury in the adult mammal, however, and the functional implications of the glial cell responses in this situation are unclear. When central axons are injured, the glial cell responses around the affected neuron perikarya appears to be minimal or absent, unless neuron degeneration occurs. Microglia proliferate, and astrocytes upregulate GFAP along central axons undergoing anterograde, Wallerian, degeneration. Although microglia develop into phagocytes, they eliminate the disintegrating myelin very slowly, presumably because they fail to release molecules which facilitate phagocytosis. During later stages of Wallerian degeneration, oligodendrocytes express clusterin, a glycoprotein implicated in several conditions of cell degeneration. A hypothetical scheme for glial cell activation following axon injury is discussed, implying the injured neurons initially interact with adjacent astrocytes. Subsequently, neighbouring resting microglia are activated. These glial reactions are amplified by paracrine and autocrine mechanisms, in which cytokines appear to be important mediators. The specific functional properties of the activated glial cells will determine their influence on neuronal survival, axon regeneration, and synaptic plasticity. The control of the induction and progression of these responses are therefore likely to be critical for the outcome of, for example, neurotrauma, brain ischemia and chronic neurodegenerative diseases.

  • 24239.
    Aldskogius, Håkan
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neuroanatomy.
    Kozlova, Elena N.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neuroanatomy.
    Microglia and Neuropathic Pain2013In: CNS & Neurological Disorders: Drug Targets, ISSN 1871-5273, E-ISSN 1996-3181, Vol. 12, no 6, p. 768-772Article in journal (Refereed)
    Abstract [en]

    Neuropathic pain is a serious consequence of injury or disease in the nervous system itself. Current treatment options for this condition are often unsatisfactory. From being originally viewed as a diseased caused by neuronal dysfunction, a growing body of evidence implicate activated microglia as a key player in the development of this pain condition. In this review, some of the evidence for this proposal is briefly discussed and placed in a translational context, pointing out the difficulties in translating commonly used animal models of neuropathic pain to the clinical condition, as well as emphasizing the broader role of activated microglia in the injured or diseased nervous system.

  • 24240.
    Aldskogius, Håkan
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neuroanatomy.
    Kozlova, Elena N.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neuroanatomy.
    Strategies for repair of the deafferented spinal cord2002In: Brain Research Reviews, ISSN 0165-0173, E-ISSN 1872-6321, Vol. 40, no 1-3, p. 301-308Article in journal (Refereed)
    Abstract [en]

    Deafferentation of the spinal cord by interruption of the sensory fibers in the dorsal roots highlights the problem of regeneration failure in the central nervous system. The injured dorsal root axons regenerate steadily, albeit slowly, in the peripheral compartment of the dorsal root, but abruptly cease to elongate when confronted with the interface between the peripheral and central nervous system, the dorsal root transitional zone (DRTZ). The glial cells of the CNS and their products together form this regeneration barrier. Recent years have witnessed several successful approaches to, at least in part, overcome this barrier. Particularly promising results have been obtained by (1). the replacement of adult non-regenerating dorsal root ganglion neurons with corresponding cells from embryonic or fetal donors, (2). the implantation of olfactory ensheathing cells at the DRTZ, and (3). immediate intrathecal infusion of growth factors to which dorsal root ganglion cells respond. In all these instances, growth of sensory axons into the adult spinal cord, as well as return of spinal cord connectivity, have been demonstrated. These findings suggest routes towards treatment strategies for plexus avulsion, and contribute to our understanding of possibilities to overcome regeneration failure in the spinal cord.

  • 24241.
    Aldskogius, Håkan
    et al.
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
    Liu, Li
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
    Eriksson, Petri
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
    Persson, Jonas
    Svensson, Mikael
    The response of microglia to axon injury1997In: Neurochemistry, 1997, p. 549-Chapter in book (Other scientific)
  • 24242.
    Aldskogius, Håkan
    et al.
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
    Liu, Li
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
    Svensson, Mikael
    Clusterin in models of central and peripheral injury and for ischemia and trauma1999In: In: Clusterin in normal brain functions and during neurodegeneration, R.G.Landes Company , 1999, p. 99-Chapter in book (Other scientific)
  • 24243.
    Aldskogius, Håkan
    et al.
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
    Liu, Li
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
    Svensson, Mikael
    Glial responses to synaptic damage and plasticity1999In: J Neurosci Res, Vol. 58, p. 33-Article in journal (Refereed)
  • 24244.
    Aldskogius, Maj
    Uppsala University, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Faculty of Social Sciences, Department of Social and Economic Geography.
    Anjans fjällstation - en pärla i Jämtlands fjällvärld2003Book (Other scientific)
  • 24245. Aldskogius, Maj
    "… kunn’ I dock så wackert låta …": Uppsala Akademiska Kammarkör 50 år2007Collection (editor) (Other academic)
    Abstract [en]

    A 50th anniversary portrait of the artistically ambitious Academy Chamber Choir of Uppsala is drawn by a variety of authors: choristers, listeners and musicologists,all familiar with choral singing and choral music.

    The characteristics of the choir repertoire are extensively described by conductors, composers, Swedish and foreign soloists and instrumentalists. The choir has commissioned and delivered first performances of works by a number of Swedish composers.

    It can also be noticed how economic and organizational changes in society influence the motility of choristers, the number of performances in concert halls, churches as well as other circumstances and possibly also the very choral sound.

    The choir is invited to choral festivals, goes on tours in Europe and North America and hosts visiting choirs. The choir can also be heard on records.

  • 24246.
    Aldskogius, Maj
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences.
    Population Change and Urban Growth: A Study of Large and Medium-Sized Urban Regions in Sweden1970In: Geografiska Annaler. Series B, Human Geography, ISSN 0435-3684, E-ISSN 1468-0467, Vol. B 52, no 2, p. 131-140Article in journal (Refereed)
  • 24247.
    Aldskogius, Suzanne
    et al.
    Stockholm University, Faculty of Social Sciences, Department of Special Education.
    Persson, Katja
    Stockholm University, Faculty of Social Sciences, Department of Special Education.
    Play Time/Social Time: ett sätt att främja inkludering i svensk förskola?2016Independent thesis Advanced level (professional degree), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Research shows that children in need of special support do not participate in play with peers to the same extent as their peers and therefore risk missing important parts of their development, such as interaction and participation. The purpose of this study was to examine opportunities and possible barriers in the application of the evidence-based program Playtime / Social Time, as a method to develop social skills and interaction in the play of children with special educational needs and their peers, using a peer-mediated approach. The study highlights a socio-cultural perspective where learning and development takes place through interaction with others. The empirical data were collected through four observations in two inclusive pre-school classes with XX children aged 3-5, and through five focus conversations with two preschool teachers during 5 weeks, when the application of some program activities was carried out by the teachers in their classes. One prominent result shows that preschool teachers welcomes the use of an evidence-based material to practice play and interaction with the children. The teachers believe that it would benefit all children on many levels. Another perceived benefit of the program is that it contributes to making play and play skills visible for teachers and children and give support in considering play as a democratic right for children. An issue, which the participants acknowledge they have to think more about, concerns if and how peers would be motivated to be role models in the play situation. The focus of the discussion lies in the result of the importance of the environment for social encounters and on the importance of the role of peers in the program.

  • 24248.
    Aldskogius, Suzanne
    et al.
    Stockholm University, Faculty of Social Sciences, Department of Special Education.
    Persson, Katja
    Stockholm University, Faculty of Social Sciences, Department of Special Education.
    Play Time/Social Time: Ett sätt att främja inkludering i svensk förskola?2016Independent thesis Advanced level (professional degree), 10 credits / 15 HE creditsStudent thesis
  • 24249.
    Aldstam, Gofi
    Linnaeus University, School of Business and Economics, Department of Organisation and Entrepreneurship.
    Fördelning i hållbarhetsrapportering: - en uppsats om svenska företag och organisationers hållbarhetsrapportering2016Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Abstract

    Bachelor Thesis, Business Administration III- Organisation, School of Business and Economics, Linnaeus University, 2FE95E, Spring 2016. Author: Gofi Aldstam Supervisor: John Jeansson

    Title: Distribution within sustainability reporting – a thesis regarding sustainability reporting from Swedish companies and organisations

    Problem: CSR reporting is increasing within companies and organisations, but to report on three CSR perspectives: socially, environmentally and economically is not enough. The three CSR perspectives need to be evenly distributed to create long-term business and organisations that contribute to a prosperous society.

    Purpose: The purpose of the thesis is to examine the extent to which Swedish companies and organisations reported data on all three CSR perspectives and how even distribution between the reported CSR perspectives are. The purpose is also to investigate whether the rate of reporting on the number of CSR perspectives and the distribution between the three CSR perspectives, differ, based on the factors owner, market and international business.

    Method: The study was a cross-sectional design with quantitative approach. Secondary analysis was used as a method, when the analysis was made by CSR reports retrieved from the database of the Global Reporting Initiative (GRI). Excel was used for the compilation of data. Based on the theoretical framework information was analyzed from the GRI database.

    Results: This study shows that most companies and organisations report on all CSR perspectives. Swedish companies and organisations appear to have equal distribution between CSR perspectives. The results do not differ significantly regarding the factors owner, market and international business, except on reporting rate for CSR perspectives and to some extent distribution between CSR perspectives.

    Key words: Sustainability, CSR, GRI, distribution, owner, market, international 

  • 24250.
    Aldstedt, Kajsa
    Stockholm University, Faculty of Law, Department of Law.
    Ekonomisk asyl: en ofrivillig reform2016Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
482483484485486487488 24201 - 24250 of 1157239
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