Endre søk
Begrens søket
33343536373839 1751 - 1800 of 1903
RefereraExporteraLink til resultatlisten
Permanent link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Treff pr side
  • 5
  • 10
  • 20
  • 50
  • 100
  • 250
Sortering
  • Standard (Relevans)
  • Forfatter A-Ø
  • Forfatter Ø-A
  • Tittel A-Ø
  • Tittel Ø-A
  • Type publikasjon A-Ø
  • Type publikasjon Ø-A
  • Eldste først
  • Nyeste først
  • Skapad (Eldste først)
  • Skapad (Nyeste først)
  • Senast uppdaterad (Eldste først)
  • Senast uppdaterad (Nyeste først)
  • Disputationsdatum (tidligste først)
  • Disputationsdatum (siste først)
  • Standard (Relevans)
  • Forfatter A-Ø
  • Forfatter Ø-A
  • Tittel A-Ø
  • Tittel Ø-A
  • Type publikasjon A-Ø
  • Type publikasjon Ø-A
  • Eldste først
  • Nyeste først
  • Skapad (Eldste først)
  • Skapad (Nyeste først)
  • Senast uppdaterad (Eldste først)
  • Senast uppdaterad (Nyeste først)
  • Disputationsdatum (tidligste først)
  • Disputationsdatum (siste først)
Merk
Maxantalet träffar du kan exportera från sökgränssnittet är 250. Vid större uttag använd dig av utsökningar.
  • 1751.
    Unsworth, Carolyn A.
    et al.
    Högskolan i Jönköping, Hälsohögskolan. Faculty of Health Sciences, La Trobe University, Melbourne 3086, VIC, Australia.
    Baker, Anne
    Faculty of Health Sciences, La Trobe University, Melbourne 3086, VIC, Australia.
    Driver rehabilitation: A systematic review of the types and effectiveness of interventions used by occupational therapists to improve on-road fitness-to-drive2014Inngår i: Accident Analysis and Prevention, ISSN 0001-4575, E-ISSN 1879-2057, Vol. 71, s. 106-114Artikkel, forskningsoversikt (Fagfellevurdert)
    Abstract [en]

    Objective: Driver rehabilitation has the potential to improve on-road safety and is commonly recommended to clients. The aim of this systematic review was to identify what intervention approaches are used by occupational therapists as part of driver rehabilitation programmes, and to determine the effectiveness of these interventions. Method: Six electronic databases (MEDLINE, CINAHL, Psycinfo, Embase, The Cochrane Library, and OTD-Base) were searched. Two authors independently reviewed studies reporting all types of research designs and for all patient populations, provided the interventions could be administered by occupational therapists. The methodological quality of studies was assessed using the 'Downs and Black Instrument', and the level of evidence for each intervention approach was established using 'Centre for Evidence Based Medicine' criteria. Results: Sixteen studies were included in the review. The most common type of intervention approach used was computer-based driving simulator training (n=8), followed by off-road skill-specific training (n=4), and off-road education programmes (n=3). Car adaptations/modifications were used in one of the included studies. There was significant variability between studies with regards to frequency, duration, and total number of intervention sessions, and the diagnoses of the participants. Of the four intervention approaches, there is evidence to support the effectiveness of off-road skill-specific training (with older clients), and computer-based driving simulator training (with both older clients and participants with acquired brain injury). Conclusion: Three types of intervention approaches are commonly reported, however, there is limited evidence to determine to effectiveness of these in improving fitness-to-drive. Further research is required, with clients from a range of diagnostic groups to establish evidence-based interventions and determine their effectiveness in improving these clients' on-road fitness-to-drive. Crown Copyright (C) 2014 Published by Elsevier Ltd. All rights reserved.

  • 1752. Vaez, Marjan
    et al.
    Josephson, Malin
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Arbets- och miljömedicin.
    Vingård, Eva
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Arbets- och miljömedicin.
    Voss, Margaretha
    Work-related violence and its association with self-rated general health among public sector employees in Sweden2014Inngår i: Work: A journal of Prevention, Assesment and rehabilitation, ISSN 1051-9815, E-ISSN 1875-9270, Vol. 49, nr 1, s. 163-171Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    BACKGROUND:

    Work-related violence is one of the most serious threats to employee safety and health.

    OBJECTIVE:

    To ascertain the extent of self-reported violence or threats of violence at work in relation to the general health of public sector employees.

    METHODS:

    The study population comprised 9,611 female (83%) and male public employees in Sweden. A questionnaire based on items derived mainly from validated instruments was constructed to cover aspects such as health, lifestyle, and physical and psychosocial work conditions.

    RESULTS:

    One in three employees reported work-related violence, with the highest proportions among psychiatric nurses (79%) and psychiatric attendants (75%). Work-related violence more often affected those who were < 45 years old, worked < 40 hours/week, worked nights, or reported poor health. Regardless of gender, age, hours of work, night work, and type of occupation, exposure to work-related violence was associated with less than good general health, and this relationship was strongest for psychiatric nurses (OR=3.19; 95% CI=1.28-7.98), medical doctors/dentists (OR=2.46; 95% CI=1.35-4.49), compulsory school teachers (OR=2.14; 95% CI=1.33-3.45), and other nurses (OR=1.87; 95% CI=1.23-2.84).

    CONCLUSIONS:

    Work-related violence was frequently reported by employees in the most common public sector occupations, and it was associated withpoor health in both genders.

  • 1753. Vaittinen, Olavi
    et al.
    Schmidt, Florian M.
    Metsälä, Markus
    Halonen, Lauri
    Exhaled breath biomonitoring using laser spectroscopy2013Inngår i: Current Analytical Chemistry, ISSN 1573-4110, E-ISSN 1875-6727, Vol. 9, nr 3, s. 463-475Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Biological monitoring usually relies on the collection of blood and urine samples. Although being non-invasive and providing an inextinguishable sampling pool, the analysis of exhaled breath is not well established. A gas phase measurement is, however, inherently simpler than the analysis of complex biological fluids, and modern methods have identified hundreds of volatile compounds in the breath of persons exposed to normal environmental concentrations. The most commonly deployed analytical techniques in breath analysis are gas chromatography combined with mass spectrometry (GC/MS) and other MS-based methods. Lately, also laser-based optical methods, such as cavity ring-down spectroscopy (CRDS), have emerged in the field. With such instruments, it is possible to accurately quantify the concentrations of volatiles in exhaled breath down to below part-per-billion (ppb) levels with sub-second time resolution. Laser spectroscopy thereby enables real-time investigations during and after exposure to exogenous chemicals. In general, depending on the sampling approach used, the measured levels of the breath compounds may vary significantly. It is therefore of importance to systematically study and account for the phenomena affecting the recorded concentrations, and subsequently select an appropriate sampling and measurement strategy. In Helsinki, we have used CRDS to study the background levels of hydrogen cyanide (HCN), ammonia (NH3) and acetylene (C2H2) in the exhaled breath of healthy volunteers. Different sampling techniques have been employed in an effort to standardize the breath sampling event. The realtime elimination kinetics of breath C2H2 after smoking has also been studied.

  • 1754. van de Ven, Hardy A
    et al.
    Brouwer, Sandra
    Koolhaas, Wendy
    Goudswaard, Anneke
    de Looze, Michiel P
    Kecklund, Göran
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Stressforskningsinstitutet. Radboud University, The Netherlands.
    Almansa, Josue
    Bültmann, Ute
    van der Klink, Jac J. L.
    Associations between shift schedule characteristics with sleep, need for recovery, health and performance measures for regular (semi-)continuous 3-shift systems.2016Inngår i: Applied Ergonomics, ISSN 0003-6870, E-ISSN 1872-9126, Vol. 56, s. 203-212Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    In this cross-sectional study associations were examined between eight shift schedule characteristics with shift-specific sleep complaints and need for recovery and generic health and performance measures. It was hypothesized that shift schedule characteristics meeting ergonomic recommendations are associated with better sleep, need for recovery, health and performance. Questionnaire data were collected from 491 shift workers of 18 companies with 9 regular (semi)-continuous shift schedules. The shift schedule characteristics were analyzed separately and combined using multilevel linear regression models. The hypothesis was largely not confirmed. Relatively few associations were found, of which the majority was in the direction as expected. In particular early starts of morning shifts and many consecutive shifts seem to be avoided. The healthy worker effect, limited variation between included schedules and the cross-sectional design might explain the paucity of significant results.

  • 1755. van den Berg, Johannes
    et al.
    Landström, Ulf
    Högskolan i Gävle, Institutionen för teknik och byggd miljö, Ämnesavdelningen för inomhusmiljö.
    Dålig sömn ger trötta yrkesförare2006Rapport (Annet vitenskapelig)
  • 1756. van den Berg, Johannes
    et al.
    Landström, Ulf
    Högskolan i Gävle, Institutionen för teknik och byggd miljö, Ämnesavdelningen för inomhusmiljö.
    Mätmetoder av sömnighet2006Rapport (Annet vitenskapelig)
  • 1757. van den Berg, Johannes
    et al.
    Landström, Ulf
    Högskolan i Gävle, Institutionen för teknik och byggd miljö, Ämnesavdelningen för inomhusmiljö.
    Symptoms of sleepiness while driving and their relationship to prior sleep, work and individual characteristics2006Inngår i: Transportation Research Part F: Traffic Psychology and Behaviour, ISSN 1369-8478, E-ISSN 1873-5517, Vol. 9, nr 3, s. 207-226Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    In total, 154 lorry and bus drivers participated in a questionnaire study dealing with sleepiness in traffic. The questionnaire included questions about sleep before work, appearance of sleepiness, the type of sleepiness they experienced while driving, and ways to counter sleepiness while driving. Driver sleepiness was analysed with respect to age, type of driving, traffic intensity, experience of work, and sleep before work. About 14% of the drivers reported regular sleepiness while driving, 33% had occasionally fought sleepiness while driving, and 8% had experienced nodding of the head while driving. The majority of the drivers had once been so tired that they had to stop driving. Sleepiness normally occurred between 03.00 and 06.00, at the end of longer trips, and was most frequently appeared in autumn. Poor sleep and poor working hours were considered as the most important causes to sleepiness. Eye tiredness, yawning, difficulties concentrating on the road, and difficulties keeping one’s thoughts together: these were the most frequently reported symptoms of sleepiness. More sleeping hours before work, better working hours, naps during work, listening to the radio, conversations, and lowering the cabin temperature were the most frequently mentioned countermeasures. The appearances of sleepiness while driving was strongly correlated to lower sleep hours and lower sleep quality before work. Age, type of work, or work experience did not interfere with sleepiness in the investigated group in any systematic way.

  • 1758.
    van den Berg, Johannes
    et al.
    National Institute of Working Life, Umeå, Sweden.
    Neely, Gregory
    National Institute of Working Life, Umeå, Sweden.
    Wiklund, Urban
    Department of Biomedical Engineering and Informatics, University Hospital, Umeå, Sweden.
    Landström, Ulf
    National Institute of Working Life, Umeå, Sweden.
    Heart rate variability during sedentary work and sleep in normal and sleep-deprived states2006Inngår i: Clinical Physiology and Functional Imaging, ISSN 1475-0961, E-ISSN 1475-097X, Vol. 25, s. 51-57Artikkel i tidsskrift (Fagfellevurdert)
  • 1759.
    van der Beek, Allard
    et al.
    Department of Public and Occupational Health, Amsterdam Public Health research institute, VU University Medical Centre, Amsterdam.
    Dennerlein, Jack T.
    Bouvé College of Health Sciences, Northeastern University, Boston.
    Huysmans, Maaike
    Department of Public and Occupational Health, Amsterdam Public Health research institute, VU University Medical Centre, Amsterdam.
    Mathiassen, Svend Erik
    Högskolan i Gävle, Akademin för hälsa och arbetsliv, Avdelningen för arbets- och folkhälsovetenskap, Arbetshälsovetenskap. Högskolan i Gävle, Centrum för belastningsskadeforskning.
    Burdorf, Alex
    Department of Public Health, Erasmus MC, University Medical Center Rotterdam.
    van Mechelen, Willem
    Department of Public and Occupational Health, Amsterdam Public Health research institute, VU University Medical Centre, Amsterdam.
    van Dieën, Jaap
    Department of Human Movement Sciences, Vrije Universiteit Amsterdam.
    Frings-Dresen, Monique
    Academic Medical Center, Department Coronel Institute of Occupational Health and Netherlands Center for Occupational Diseases, Amsterdam.
    Holtermann, Andreas
    National Research Centre for the Working Environment, Copenhagen.
    Janwantanakul, Prawit
    Work-related Musculoskeletal Injury Research Unit, Department of Physical Therapy, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok.
    van der Molen, Henk
    Academic Medical Center, Department Coronel Institute of Occupational Health and Netherlands Center for Occupational Diseases, Amsterdam.
    Rempel, David
    Division of Occupational and Environmental Medicine, University of California, San Francisco.
    Straker, Leon
    Curtin University, School of Physiotherapy and Exercise Science, Perth.
    Walker-Bone, Karen
    Arthritis Research UK/MRC centre for Musculoskeletal Health and Work, University of Southampton.
    Coenen, Pieter
    Department of Public and Occupational Health, Amsterdam Public Health research institute, VU University Medical Centre, Amsterdam.
    A research framework for the development and implementation of interventions preventing work-related musculoskeletal disorders2017Inngår i: Scandinavian Journal of Work, Environment and Health, ISSN 0355-3140, E-ISSN 1795-990X, Vol. 43, nr 6, s. 526-539Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objectives: Work-related musculoskeletal disorders (MSD) are highly prevalent and put a large burden on the (working) society. Primary prevention of work-related MSD focuses often on physical risk factors (such as on manual lifting and awkward postures), but has not been too successful in reducing the MSD burden. This may partly be caused by insufficient knowledge of etiological mechanisms and/or a lack of adequately feasible interventions (theory failure and program failure, respectively), possibly due to limited integration of research disciplines. A research framework could link research disciplines thereby strengthening the development and implementation of preventive interventions. Our objective was to define and describe such a framework for multi-disciplinary research on work-related MSD prevention.

    Methods: We described a framework for MSD prevention research, partly based on frameworks from other research fields (i.e., sports injury prevention and public health).

    Results: The framework is composed of a repeated sequence of six steps comprising the assessment of 1) incidence and severity of MSD, 2) risk factors for MSD, and 3) underlying mechanisms; and the 4) development, 5) evaluation, and 6) implementation of preventive intervention(s).

    Conclusions: In the present framework for optimal work-related MSD prevention, research disciplines are linked. This framework can thereby help to improve theories and strengthen the development and implementation of prevention strategies for work-related MSD.

  • 1760.
    van der Beek, Allard
    et al.
    Department of Public and Occupational Health, VU Medical Center, Amsterdam.
    Mathiassen, Svend Erik
    Högskolan i Gävle, Akademin för hälsa och arbetsliv, Avdelningen för arbets- och folkhälsovetenskap, Arbetshälsovetenskap. Högskolan i Gävle, Centrum för belastningsskadeforskning.
    Burdorf, Alex
    Department of Public Health, Erasmus MC, Rotterdam.
    Efficient assessment of exposure to manual lifting using company data2013Inngår i: Applied Ergonomics, ISSN 0003-6870, E-ISSN 1872-9126, Vol. 44, nr 3, s. 360-365Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The objective of this study, based on an extensive dataset on manual materials handling during scaffolding, was to explore whether routinely collected company data can be used to estimate exposure to manual lifting.The number of manual lifts of scaffold parts while constructing/dismantling scaffolds was well predicted by the number of scaffolders in the team and the type of worksite, in combination with company data of either the number of scaffold parts or the scaffold volume. The proportion of explained variance in the number of lifts ranged from 77% to 92%, depending on the variables in the model. Data on scaffold parts and scaffold volume can easily be obtained from the company’s administration, since this is its usual paperwork supporting logistics and customer invoicing, respectively.We conclude that company data can be a promising source of information for ergonomic practitioners and researchers, to support assessment of manual lifting in scaffolding.

  • 1761.
    van Ede, Karin I.
    et al.
    Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands.
    Andersson, Patrik L.
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
    Gaisch, Konrad P. J.
    Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands.
    van den Berg, Martin
    Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands.
    van Duursen, Majorie B. M.
    Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands.
    Comparison of Intake and Systemic Relative Effect Potencies of Dioxin-like Compounds in Female Mice after a Single Oral Dose2013Inngår i: Journal of Environmental Health Perspectives, ISSN 0091-6765, E-ISSN 1552-9924, Vol. 121, nr 7, s. 847-853Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    BACKGROUND: Risk assessment for mixtures of polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and polychlorinated biphenyls (PCBs) is performed using the toxic equivalency factor (TEF) approach. These TEF values are derived mainly from relative effect potencies (REPs) linking an administered dose to an in vivo toxic or biological effect, resulting in "intake" TEFs. At present, there is insufficient data available to conclude that intake TEFs are also applicable for systemic concentrations (e. g., blood and tissues). OBJECTIVE: We compared intake and systemic REPs of 1,2,3,7,8-pentachlorodibenzodioxin (PeCDD), 2,3,4,7,8-pentachlorodibenzofuran (4-PeCDF), 3,3', 4,4', 5-pentachlorobiphenyl (PCB-126), 2,3', 4,4', 5-pentachlorobiphenyl (PCB-118), and 2,3,3', 4,4', 5-hexachlorobiphenyl (PCB-156) in female C57BL/6 mice 3 days after a single oral dose. METHODS: We calculated intake REPs and systemic REPs based on administered dose and liver, adipose, or plasma concentrations relative to TCDD. Hepatic cytochrome P450 1Al-associated ethoxyresorufin-O-deethylase (EROD) activity and gene expression of Cyp1a1, 1a2 and 1b1 in the liver and peripheral blood lymphocytes (PBLs) were used as biological end points. RESULTS: We observed up to one order of magnitude difference between intake REPs and systemic REPs. Two different patterns were discerned. Compared with intake REPs, systemic REPs based on plasma or adipose levels were higher for PeCDD, 4-PeCDF, and PCB-126 but lower for the mono-ortho PCBs 118 and 156. CONCLUSIONS: Based on these mouse data, the comparison between intake REPs and systemic REPs reveals significant congener-specific differences that warrants the development of systemic TEFs to calculate toxic equivalents (TEQs) in blood and body tissues.

  • 1762.
    Van Minh, Hoang
    et al.
    Hanoi Med Univ, Dept Hlth Econ, Hanoi, Vietnam.
    Pocock, Nicola Suyin
    London Sch Hyg & Trop Med, London WC1, England.
    Chaiyakunapruk, Nathorn
    Monash Univ Malaysia, Sch Pharm, Selangor, Malaysia; Naresuan Univ, Fac Pharmaceut Sci, Dept Pharm Practice, Ctr Pharmaceut Outcomes Res, Phitsanulok, Thailand; Univ Queensland, Sch Populat Hlth, Brisbane, Qld 4072, Australia.
    Chhorvann, Chhea
    Natl Inst Publ Hlth, Phnom Penh, Cambodia.
    Duc, Ha Anh
    Minist Hlth, Hanoi, Vietnam.
    Hanvoravongchai, Piya
    Chulalongkorn Univ, Fac Med, Bangkok 10330, Thailand.
    Lim, Jeremy
    Oliver Wyman, Hlth & Life Sci Practice, New York, NY USA.
    Lucero-Prisno, Don Eliseo
    Xian Jiaotong Liverpool Univ, Dept Publ Hlth, Suzhou, Peoples R China; Open Univ, Univ Philippines, Fac Management & Dev Studies, Los Banos, Philippines.
    Ng, Nawi
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Epidemiologi och global hälsa.
    Phaholyothin, Natalie
    Rockefeller Fdn, Bangkok, Thailand.
    Phonvisay, Alay
    Natl Univ Laos, Viangchan, Laos.
    Soe, Kyaw Min
    Mahidol Univ, Fac Publ Hlth, Bangkok 10700, Thailand.
    Sychareun, Vanphanom
    Univ Hlth Sci, Viangchan, Laos.
    Progress toward universal health coverage in ASEAN2014Inngår i: Global Health Action, ISSN 1654-9716, E-ISSN 1654-9880, Vol. 7, artikkel-id 25856Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    BACKGROUND: The Association of Southeast Asian Nations (ASEAN) is characterized by much diversity in terms of geography, society, economic development, and health outcomes. The health systems as well as healthcare structure and provisions vary considerably. Consequently, the progress toward Universal Health Coverage (UHC) in these countries also varies. This paper aims to describe the progress toward UHC in the ASEAN countries and discuss how regional integration could influence UHC.

    DESIGN: Data reported in this paper were obtained from published literature, reports, and gray literature available in the ASEAN countries. We used both online and manual search methods to gather the information and 'snowball' further data.

    RESULTS: We found that, in general, ASEAN countries have made good progress toward UHC, partly due to relatively sustained political commitments to endorse UHC in these countries. However, all the countries in ASEAN are facing several common barriers to achieving UHC, namely 1) financial constraints, including low levels of overall and government spending on health; 2) supply side constraints, including inadequate numbers and densities of health workers; and 3) the ongoing epidemiological transition at different stages characterized by increasing burdens of non-communicable diseases, persisting infectious diseases, and reemergence of potentially pandemic infectious diseases. The ASEAN Economic Community's (AEC) goal of regional economic integration and a single market by 2015 presents both opportunities and challenges for UHC. Healthcare services have become more available but health and healthcare inequities will likely worsen as better-off citizens of member states might receive more benefits from the liberalization of trade policy in health, either via regional outmigration of health workers or intra-country health worker movement toward private hospitals, which tend to be located in urban areas. For ASEAN countries, UHC should be explicitly considered to mitigate deleterious effects of economic integration. Political commitments to safeguard health budgets and increase health spending will be necessary given liberalization's risks to health equity as well as migration and population aging which will increase demand on health systems. There is potential to organize select health services regionally to improve further efficiency.

    CONCLUSIONS: We believe that ASEAN has significant potential to become a force for better health in the region. We hope that all ASEAN citizens can enjoy higher health and safety standards, comprehensive social protection, and improved health status. We believe economic and other integration efforts can further these aspirations.

  • 1763.
    van Vught, Anneke J. A. H.
    et al.
    Univ Limburg, Dept Human Biol, NL-6200 MD Maastricht, Netherlands; TI Food & Nutr, NL-6700 AN Wageningen, Netherlands.
    Heitmann, Berit L.
    Univ Copenhagen Hosp, Res Unit Dietary Studies, Inst Prevent Med, DK-2100 Copenhagen, Denmark.
    Nieuwenhuizen, Arie G.
    Univ Limburg, Dept Human Biol, NL-6200 MD Maastricht, Netherlands; TI Food & Nutr, NL-6700 AN Wageningen, Netherlands.
    Veldhorst, Margriet A. B.
    Univ Limburg, Dept Human Biol, NL-6200 MD Maastricht, Netherlands; TI Food & Nutr, NL-6700 AN Wageningen, Netherlands.
    Andersen, Lars Bo
    Univ So Denmark, Inst Sport Sci & Clin Biomech, Odense, Denmark.
    Hasselstrom, Henriette
    Univ So Denmark, Inst Sport Sci & Clin Biomech, Odense, Denmark.
    Brummer, Robert
    Örebro universitet, Hälsoakademin.
    Westerterp-Plantenga, Margriet S.
    Univ Limburg, Dept Human Biol, NL-6200 MD Maastricht, Netherlands; TI Food & Nutr, NL-6700 AN Wageningen, Netherlands.
    Association between intake of dietary protein and 3-year-change in body growth among normal and overweight 6-year-old boys and girls (CoSCIS)2010Inngår i: Public Health Nutrition, ISSN 1368-9800, E-ISSN 1475-2727, Vol. 13, nr 5, s. 647-653Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objective: Growth hormone (GH) affects linear growth and body composition, by increasing the secretion of insulin-like growth factor-I (IGF-I), muscle protein synthesis and lipolysis. The intake of protein (PROT) as well as the specific amino acids arginine (ARG) and lysine (LYS) stimulates GH/IGF-I secretion. The present paper aimed to investigate associations between PROT intake as well as intake of the specific amino acids ARG and LYS, and subsequent 3-year-change in linear growth and body composition among 6-year-old children.

    Design: Children's data were collected from Copenhagen (Denmark), during 2001-2002, and again 3 years later. Boys and girls were separated into normal weight and overweight, based on BMI quintiles. Fat-free mass index (FFMI) and fat mass index (FMI) were calculated. Associations between change (Delta) in height, FMI and FFMI, respectively, and habitual PROT intake as well as ARG and LYS were analysed by multiple linear regressions, adjusted for baseline height, FMI or FFMI and energy intake, age, physical activity and socio-economic status.

    Setting: Eighteen schools in two suburban communities in the Copenhagen (Denmark) area participated in the study. SUBJECTS: In all, 223 children's data were collected for the present study.

    Results: High ARG intake was associated with linear growth (beta = 1.09 (se 0.54), P = 0.05) among girls. Furthermore, in girls, DeltaFMI had a stronger inverse association with high ARG intake, if it was combined with high LYS intake, instead of low LYS intake (P = 0.03). No associations were found in boys.

    Conclusion: In prepubertal girls, linear growth may be influenced by habitual ARG intake and body fat gain may be relatively prevented over time by the intake of the amino acids ARG and LYS.

  • 1764. Vandenberg, Laura N.
    et al.
    Ågerstrand, Marlene
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljövetenskap och analytisk kemi.
    Beronius, Anna
    Beausoleil, Claire
    Bergman, Åke
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljövetenskap och analytisk kemi. Swedish Toxicology Sciences Research Center, Sweden.
    Bero, Lisa A.
    Bornehag, Carl-Gustaf
    Boyer, C. Scott
    Cooper, Glinda S.
    Cotgreave, Ian
    Gee, David
    Grandjean, Philippe
    Guyton, Kathryn Z.
    Hass, Ulla
    Heindel, Jerrold J.
    Jobling, Susan
    Kidd, Karen A.
    Kortenkamp, Andreas
    Macleod, Malcolm R.
    Martin, Olwenn V.
    Norinder, Ulf
    Scheringer, Martin
    Thayer, Kristina A.
    Toppari, Jorma
    Whaley, Paul
    Woodruff, Tracey J.
    Rudén, Christina
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljövetenskap och analytisk kemi.
    A proposed framework for the systematic review and integrated assessment (SYRINA) of endocrine disrupting chemicals2016Inngår i: Environmental health, ISSN 1476-069X, E-ISSN 1476-069X, Vol. 15, artikkel-id 74Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: The issue of endocrine disrupting chemicals (EDCs) is receiving wide attention from both the scientific and regulatory communities. Recent analyses of the EDC literature have been criticized for failing to use transparent and objective approaches to draw conclusions about the strength of evidence linking EDC exposures to adverse health or environmental outcomes. Systematic review methodologies are ideal for addressing this issue as they provide transparent and consistent approaches to study selection and evaluation. Objective methods are needed for integrating the multiple streams of evidence (epidemiology, wildlife, laboratory animal, in vitro, and in silico data) that are relevant in assessing EDCs.

    Methods: We have developed a framework for the systematic review and integrated assessment (SYRINA) of EDC studies. The framework was designed for use with the International Program on Chemical Safety (IPCS) and World Health Organization (WHO) definition of an EDC, which requires appraisal of evidence regarding 1) association between exposure and an adverse effect, 2) association between exposure and endocrine disrupting activity, and 3) a plausible link between the adverse effect and the endocrine disrupting activity.

    Results: Building from existing methodologies for evaluating and synthesizing evidence, the SYRINA framework includes seven steps: 1) Formulate the problem; 2) Develop the review protocol; 3) Identify relevant evidence; 4) Evaluate evidence from individual studies; 5) Summarize and evaluate each stream of evidence; 6) Integrate evidence across all streams; 7) Draw conclusions, make recommendations, and evaluate uncertainties. The proposed method is tailored to the IPCS/WHO definition of an EDC but offers flexibility for use in the context of other definitions of EDCs.

    Conclusions: When using the SYRINA framework, the overall objective is to provide the evidence base needed to support decision making, including any action to avoid/minimise potential adverse effects of exposures. This framework allows for the evaluation and synthesis of evidence from multiple evidence streams. Finally, a decision regarding regulatory action is not only dependent on the strength of evidence, but also the consequences of action/inaction, e.g. limited or weak evidence may be sufficient to justify action if consequences are serious or irreversible.

  • 1765. Varga, Tibor V
    et al.
    Hallmans, Göran
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Näringsforskning. Umeå universitet, Medicinska fakulteten, Enheten för biobanksforskning.
    Hu, Frank B
    Renström, Frida
    Franks, Paul W
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Medicin.
    Smoking status, snus use, and variation at the CHRNA5-CHRNA3-CHRNB4 locus in relation to obesity: the GLACIER study2013Inngår i: American Journal of Epidemiology, ISSN 0002-9262, E-ISSN 1476-6256, Vol. 178, nr 1, s. 31-37Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    A genetic variant within the CHRNA5-CHRNA3-CHRNB4 region (rs1051730), previously associated with smoking quantity, was recently shown to interact with smoking on obesity predisposition. We attempted to replicate this finding in the Gene-Lifestyle Interactions and Complex Traits Involved in Elevated Disease Risk (GLACIER) Study, a prospective cohort study of adults from northern Sweden (n = 16,426). We also investigated whether a similar interaction is apparent between rs1051730 and snus, a type of moist oral tobacco, to determine whether this interaction is driven by factors that cigarettes and snus have in common, such as nicotine. Main effects of smoking, snus, and the rs1051730 variant and pairwise interaction terms (smoking x rs1051730 and snus x rs1051730) were tested in relation to body mass index (BMI; calculated as weight (kg)/height (m)(2)) through the use of multivariate linear models adjusted for age and sex. Smoking status and BMI were inversely related (beta = -0.46 kg/m(2), standard error (SE) = 0.08; P < 0.0001). Snus use and BMI were positively related (beta = 0.35 kg/m(2), SE = 0.12; P = 0.003). The rs1051730 variant was not significantly associated with smoking status or snus use (P > 0.05); the T allele was associated with lower BMI in the overall cohort (beta = -0.10 kg/m(2), SE = 0.05; P = 0.03) and with smoking quantity in those in whom this was measured (n = 5,304) (beta = 0.08, SE = 0.01; P < 0.0001). Neither smoking status (P-interaction = 0.29) nor snus use (P-interaction = 0.89) modified the association between the rs1051730 variant and BMI.

  • 1766.
    Varga, Tibor V.
    et al.
    Lund Univ, Skåne Univ Hosp, Dept Clin Sci, Genet & Mol Epidemiol Unit.
    Kurbasic, Azra
    Lund Univ, Skåne Univ Hosp, Dept Clin Sci, Genet & Mol Epidemiol Unit.
    Aine, Mattias
    Lund Univ, Skåne Univ Hosp, Div Oncol & Pathol.
    Eriksson, Pontus
    Lund Univ, Skåne Univ Hosp, Div Oncol & Pathol.
    Ali, Ashfaq
    Lund Univ, Skåne Univ Hosp, Dept Clin Sci, Genet & Mol Epidemiol Unit.
    Hindy, George
    Skåne Univ Hosp, Diabet & Cardiovasc Dis Genet Epidemiol.
    Gustafsson, Stefan
    Uppsala universitet, Science for Life Laboratory, SciLifeLab. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Molekylär epidemiologi.
    Luan, Jian'an
    Univ Cambridge, Epidemiol Unit, Med Res Council.
    Shungin, Dmitry
    Lund Univ, Skåne Univ Hosp, Dept Clin Sci, Genet & Mol Epidemiol Unit.;Umeå Univ, Dept Odontol;Umeå Univ, Dept Publ Hlth & Clin Med.
    Chen, Yan
    Lund Univ, Skåne Univ Hosp, Dept Clin Sci, Genet & Mol Epidemiol Unit.
    Schulz, Christina-Alexandra
    Skåne Univ Hosp, Diabet & Cardiovasc Dis Genet Epidemiol.
    Nilsson, Peter M.
    Lund Univ, Skåne Univ Hosp, Dept Clin Sci.
    Hallmans, Göran
    Umeå Univ, Dept Biobank Res.
    Barroso, Ines
    Wellcome Trust Sanger Inst.;Addenbrookes Hosp, Metab Res Labs, Cambridge, Hosp, Metab Res Labs; Addenbrookes Hosp, NIHR Cambridge BiomeEngland.;Addenbrookes Hosp, NIHR Cambridge Biomed Res Ctr.
    Deloukas, Panos
    Barts & London Queen Marys Sch Med & Dent, William Harvey Res Inst.;King Abdulaziz Univ, Princess Al Jawhara Al Brahim Ctr Excellence Res, Jeddah.
    Langenberg, Claudia
    Univ Cambridge, Epidemiol Unit, Med Res Council.
    Scott, Robert A.
    Univ Cambridge, Epidemiol Unit, Med Res Council.
    Wareham, Nicholas J.
    Univ Cambridge, Epidemiol Unit, Med Res Council.
    Lind, Lars
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Kardiovaskulär epidemiologi.
    Ingelsson, Erik
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Molekylär epidemiologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab. Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford.
    Melander, Olle
    Skåne Univ, Dept Clin Sci Hypertens & Cardiovasc Dis.
    Orho-Melander, Marju
    Skåne Univ Hosp, Diabet & Cardiovasc Dis Genet Epidemiol.
    Renström, Frida
    Lund Univ, Skåne Univ Hosp, Dept Clin Sci, Genet & Mol Epidemiol Unit.;Umeå Univ, Dept Biobank Res.
    Franks, Paul W.
    Lund Univ, Skåne Univ Hosp, Dept Clin Sci, Genet & Mol Epidemiol Unit.;Umeå Univ, Dept Publ Hlth & Clin Med;Harvard TH Chan Sch Publ Hlth, Dept Nutr.
    Novel genetic loci associated with long-term deterioration in blood lipid concentrations and coronary artery disease in European adults2017Inngår i: International Journal of Epidemiology, ISSN 0300-5771, E-ISSN 1464-3685, Vol. 46, nr 4, s. 1211-1222Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: Cross-sectional genome-wide association studies have identified hundreds of loci associated with blood lipids and related cardiovascular traits, but few genetic association studies have focused on long-term changes in blood lipids.

    Methods: Participants from the GLACIER Study (N-max = 3492) were genotyped with the MetaboChip array, from which 29 387 SNPs (single nucleotide polymorphisms;replication, fine-mapping regions and wildcard SNPs for lipid traits) were extracted for association tests with 10-year change in total cholesterol (Delta TC) and triglycerides (Delta TG). Four additional prospective cohort studies (MDC, PIVUS, ULSAM, MRC Ely; N-max = 8263 participants) were used for replication. We conducted an in silico look-up for association with coronary artery disease (CAD) in the Coronary ARtery DIsease Genome-wide Replication and Meta-analysis (CARDIoGRAMplusC4D) Consortium (N similar to 190 000) and functional annotation for the top ranking variants.

    Results: In total, 956 variants were associated (P < 0.01) with either Delta TC or Delta TG in GLACIER. In GLACIER, chr19:50121999 at APOE was associated with Delta TG and multiple SNPs in the APOA1/A4/C3/A5 region at genome-wide significance (P < 5 x 10(-8)), whereas variants in four loci, DOCK7, BRE, SYNE1 and KCNIP1, reached study-wide significance (P < 1.7 x 10(-6)). The rs7412 variant at APOE was associated with DTC in GLACIER (P < 1.7 x 10(-6)). In pooled analyses of all cohorts, 139 SNPs at six and five loci were associated with Delta TC and for Delta TG, respectively (P < 10(-3)). Of these, a variant at CAPN3 (P = 1.2 x 10(-4)), multiple variants at HPR (P-min = 1.5 x 10(-6)) and a variant at SIX5 (P = 1.9 x 10(-4)) showed evidence for association with CAD.

    Conclusions: We identified seven novel genomic regions associated with long-term changes in blood lipids, of which three also raise CAD risk.

  • 1767. Vedaa, Øystein
    et al.
    Harris, Anette
    Bjorvatn, Bjørn
    Waage, Siri
    Sivertsen, Børge
    Tucker, Philip
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Stressforskningsinstitutet. Swansea University, UK.
    Pallesen, Ståle
    Systematic review of the relationship between quick returns in rotating shift work and health-related outcomes2016Inngår i: Ergonomics, ISSN 0014-0139, E-ISSN 1366-5847, Vol. 59, nr 1, s. 1-14Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    A systematic literature search was carried out to investigate the relationship between quick returns (i.e. 11.0 hours or less between two consecutive shifts) and outcome measures of health, sleep, functional ability and work-life balance. A total of 22 studies published in 21 articles were included. Three types of quick returns were differentiated (from evening to morning/day, night to evening, morning/day to night shifts) where sleep duration and sleepiness appeared to be differently affected depending on which shifts the quick returns occurred between. There were some indications of detrimental effects of quick returns on proximate problems (e.g. sleep, sleepiness and fatigue), although the evidence of associations with more chronic outcome measures (physical and mental health and work-life balance) was inconclusive. Practitioner Summary: Modern societies are dependent on people working shifts. This study systematically reviews literature on the consequences of quick returns (11.0 hours or less between two shifts). Quick returns have detrimental effects on acute health problems. However, the evidence regarding effects on chronic health is inconclusive.

  • 1768.
    Veiersted, Kaj Bo
    et al.
    National Institute of Occupational Health, Oslo.
    Forsman, Mikael
    Högskolan i Gävle, Akademin för hälsa och arbetsliv, Avdelningen för arbets- och folkhälsovetenskap, Arbetshälsovetenskap. Högskolan i Gävle, Centrum för belastningsskadeforskning.
    Hansson, Gert-Åke
    Division of Occupational and Environmental Medicine, Lund University.
    Mathiassen, Svend Erik
    Högskolan i Gävle, Akademin för hälsa och arbetsliv, Avdelningen för arbets- och folkhälsovetenskap, Arbetshälsovetenskap. Högskolan i Gävle, Centrum för belastningsskadeforskning.
    Assessment of time patterns of activity and rest in full-shift recordings of trapezius muscle activity - effects of the data processing procedure2013Inngår i: Journal of Electromyography & Kinesiology, ISSN 1050-6411, E-ISSN 1873-5711, Vol. 23, nr 3, s. 540-547Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The purpose of this paper was to compare the effects of different data reduction procedures on the values of variables characterizing the time pattern of trapezius muscle activity during full work shifts. Surface electromyography (EMG) of the right and left upper trapezius muscles were obtained from 40 young subjects in different occupations, mainly electricians, hairdressers and students. The target EMG variables were gap frequency, muscle rest, and the number and duration of episodes with sustained muscle activity (from 0.13 s to 30 min as minimum duration). These variables were derived from the EMG recordings using different Root Mean Square (RMS) windows (from 0.13 to 6.38 s), and discrimination levels between "activity" and "rest" (0.5, 1 and 2 % of maximal EMG). The results give basis for practical suggestions for EMG analyses of full work shifts. For most variables, a discrimination level of 0.5% EMGmax showed to be preferable. The time proportion of muscle rest and sustained muscle activity should, in general, be preferred over the corresponding frequency measures. Sustained muscle activity should be calculated using a RMS window between 1 and 3 s, and preferably be stated in terms of variables describing time proportions of activity. Uninterrupted activity episodes longer than 10 min proved not to be a useful variable due to limited occurrence in many work shifts.

  • 1769.
    Vicedo-Cabrera, Ana M
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Yrkes- och miljömedicin. Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, University of Basel, Basel, Switzerland; .
    Forsberg, Bertil
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Yrkes- och miljömedicin.
    Tobias, Aurelio
    Barcelona, Spain.
    Zanobetti, Antonella
    Boston, Massachusetts.
    Schwartz, Joel
    Boston, Massachusetts.
    Armstrong, Ben
    London, United Kingdom.
    Gasparrini, Antonio
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Yrkes- och miljömedicin. Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London, United Kingdom.
    Associations of Inter- and Intraday Temperature Change With Mortality2016Inngår i: American Journal of Epidemiology, ISSN 0002-9262, E-ISSN 1476-6256, Vol. 183, nr 4, s. 286-293Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    In this study we evaluated the association between temperature variation and mortality and compared it with the contribution due to mean daily temperature in 6 cities with different climates. Quasi-Poisson time series regression models were applied to estimate the associations (relative risk and 95% confidence interval) of mean daily temperature (99th and 1st percentiles, with temperature of minimum mortality as the reference category), interday temperature variation (difference between the mean temperatures of 2 neighboring days) and intraday temperature variation (diurnal temperature range (DTR)) (referred to as median variation) with mortality in 6 cities: London, United Kingdom; Madrid, Spain; Stockholm, Sweden; New York, New York; Miami, Florida; and Houston, Texas (date range, 1985-2010). All cities showed a substantial increase in mortality risk associated with mean daily temperature, with relative risks reaching 1.428 (95% confidence interval (CI): 1.329, 1.533) for heat in Madrid and 1.467 (95% CI: 1.385, 1.555) for cold in London. Inconsistent results for inter-/intraday change were obtained, except for some evidence of protective associations on hot and cold days (relative risk (RR) = 0.977 (95% CI: 0.955, 0.999) and RR = 0.981 (95% CI: 0.971, 0.991), respectively) in Madrid and on cold days in Stockholm (RR = 0.989, 95% CI: 0.980, 0.998). Our results indicate that the association between mortality and temperature variation is generally minimal compared with mean daily temperatures, although further research on intraday changes is needed.

  • 1770.
    Vicedo-Cabrera, Ana M.
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Yrkes- och miljömedicin.
    Olsson, David
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Yrkes- och miljömedicin.
    Forsberg, Bertil
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Yrkes- och miljömedicin.
    Exposure to Seasonal Temperatures during the Last Month of Gestation and the Risk of Preterm Birth in Stockholm2015Inngår i: International Journal of Environmental Research and Public Health, ISSN 1661-7827, E-ISSN 1660-4601, Vol. 12, nr 4, s. 3962-3978Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Recent evidence from studies performed mainly in warm climates suggests an association between exposure to extreme temperatures late in pregnancy and an increased risk of preterm delivery. However, there have been fewer studies on the effect of low temperatures. The aim of this study is to explore the potential association between both heat and cold during late pregnancy and an increased risk of preterm birth in the northern location of Stockholm, Sweden. All singleton spontaneous births that took place in greater Stockholm (1998-2006) were included. Non-linear and delayed effects of mean temperature on the risk of preterm birth were explored through distributed lag non-linear models. Extreme and moderate heat and cold were estimated separately through quasi-Poisson regression analysis in two seasonal periods (heat in warm season, cold in cold season). The risk of preterm birth increased by 4%-5% when the mean temperature reached the 75th percentile (moderate heat) four weeks earlier (reference: the annual median value), with a maximum cumulative risk ratio of 2.50 (95% confidence interval: 1.02-6.15). Inconsistent associations were obtained for cold and extreme heat. Exposure to moderately high temperatures during late pregnancy might be associated with an increase in risk of preterm birth in Stockholm.

  • 1771.
    Vihlborg, Per
    et al.
    Faculty of Medicine and Health, Department of Occupational and Environmental Medicine, Örebro University, Örebro, Sweden.
    Bryngelsson, Ing-Liss
    Faculty of Medicine and Health, Department of Occupational and Environmental Medicine, Örebro University, Örebro, Sweden.
    Andersson, Lena
    Faculty of Medicine and Health, Department of Occupational and Environmental Medicine, Örebro University, Örebro, Sweden.
    Graff, Pål
    Örebro universitet, Institutionen för medicinska vetenskaper. Region Örebro län. Department of Occupational and Environmental Medicine.
    Risk of sarcoidosis and seropositive rheumatoid arthritis from occupational silica exposure in Swedish iron foundries: a retrospective cohort study2017Inngår i: BMJ Open, ISSN 2044-6055, E-ISSN 2044-6055, Vol. 7, nr 7, artikkel-id e016839Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    OBJECTIVE: To study the impact of occupational silica exposure on the incidence rates of sarcoidosis and rheumatoid arthritis (RA) in a cohort of exposed workers in Swedish iron foundries.

    DESIGN: The prevalence of sarcoidosis and RA in a cohort of silica exposed workers was compared with the prevalence in the general Swedish population in this register study. A mixed model was used to calculate silica exposure, and individual silica exposures were used to compute dose responses.

    SETTING: Personnel records from 10 iron foundries were used to identify workers whose employment began before 2005 which was then linked to the national non-primary outpatient visits register.

    PARTICIPANTS: The final cohort consisted of 2187 silica-exposed male workers who had been employed for at least 1 year and were still alive without having emigrated when the follow-up study began. The cohort's employment period covers 23 807 person-years at risk.

    MAIN OUTCOME: The presented results indicate that moderate to high levels of silica exposure increase risks for sarcoidosis and seropositive RA.

    RESULTS: Mean levels of airborne silica dust in the foundries decreased significantly between the 1970s and 2000s. Incidence rates of sarcoidosis (3.94; 95% CI 1.07 to 10.08) and seropositive RA (2.59; 95% CI 1.24 to 4.76) were significantly higher among highly exposed individuals.

    CONCLUSION: Our results reveal increased risks for sarcoidosis and seropositive RA among individuals with high exposure to silica dust (>0.048 mg/m(3)) compared with non-exposed and less-exposed groups.

  • 1772.
    Vihlborg, Per
    et al.
    Department of Occupational and Environmental Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
    Bryngelsson, Ing-Liss
    Department of Occupational and Environmental Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
    Lindgren, Bernt
    Feelgood Hallsberg, Hallsberg, Sweden.
    Gunnarsson, Lars-Gunnar
    Örebro universitet, Institutionen för medicinska vetenskaper. Department of Occupational and Environmental Medicine.
    Graff, Pål
    Örebro universitet, Institutionen för medicinska vetenskaper. Region Örebro län. Department of Occupational and Environmental Medicine.
    Association between vibration exposure and hand-arm vibration symptoms in a Swedish mechanical industry2017Inngår i: International Journal of Industrial Ergonomics, ISSN 0169-8141, E-ISSN 1872-8219, Vol. 62, s. 77-81Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Work with vibrating tools is common in many industries. Exposure to hand-arm vibrations is associated with a risk of hand injury in the form of: Vascular disorders, nerve malfunction, and effects on the musculoskeletal system. The aim of this study was to investigate the prevalence of hand-arm vibration symptoms among employees at a mechanical company, as well as to follow-up with patients presenting symptoms and evaluate the effects of certain proposed measures. We found that 21% of the employees were judged to have vibration-related problems even though the exposure to vibrations was judged to be relatively low. There seems to be an over-representation of Carpal tunnel syndrome among participants; this may suggest that ergonomic conditions at the investigated company, such as grinding with flexed wrists, are unfavorable.

    Relevance to industry: Regular screening for early signs of vibration-related damage, even if workers are subject to only moderate vibration exposure, is an important part of preventing the aggravation of health problems.

  • 1773.
    Village, J
    et al.
    School of Environmental Health, College for Interdisciplinary Studies, University of British Columbia.
    Trask, Catherine
    Högskolan i Gävle, Akademin för hälsa och arbetsliv, Avdelningen för arbets- och folkhälsovetenskap, CBF. Högskolan i Gävle, Centrum för belastningsskadeforskning.
    Chow, Y
    School of Environmental Health, College for Interdisciplinary Studies, University of British Columbia.
    Morrison, J B
    School of Biomedical Physiology and Kinesiology, Simon Fraser University.
    Koehoorn, Mieke
    School of Environmental Health, College for Interdisciplinary Studies, University of British Columbia.
    Teschke, Kay
    School of Environmental Health, College for Interdisciplinary Studies, University of British Columbia.
    Assessing whole body vibration exposure for use in epidemiological studies of back injuries: measurements, observations and self-reports2012Inngår i: Ergonomics, ISSN 0014-0139, E-ISSN 1366-5847, Vol. 55, nr 4, s. 415-424Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Improved assessment of whole body vibration exposure is needed for epidemiological studies investigating the causes of low back disorders. Vibration was measured on 54 worker-days in five heavy industries, with data collected on observed and self-reported driving conditions, demographics, and vehicle characteristics. Variables significant at p<0.1 in simple linear regressions (20 of 34) were retained for mixed effects multiple regressions to determine the best prediction of rms vibration level and 8-h equivalent vibration exposure. Vibration was measured, on average, for 205 min per work shift (SD 105). Means and standard deviations in ms-2 were: x-axis 0.35 (0.19); y-axis 0.34 (0.28); z-axis 0.54 (0.23); vector sum 0.90 (0.49); and 8-h equivalent vector sum 0.70 (0.37). The final three regression models retained only 2 or 3 of the 34 variables (driving speed (<20 km/h and/or 20–40 km/h) and industry and/or vehicle type and explained up to 60% of the variance (R2=0.26–0.6))

  • 1774. Viluksela, Matti
    et al.
    Heikkinen, Päivi
    van der Ven, Leo T M
    Rendel, Filip
    Roos, Robert
    Esteban, Javier
    Korkalainen, Merja
    Lensu, Sanna
    Miettinen, Hanna M
    Savolainen, Kari
    Sankari, Satu
    Lilienthal, Hellmuth
    Adamsson, Annika
    Toppari, Jorma
    Herlin, Maria
    Finnilä, Mikko
    Tuukkanen, Juha
    Leslie, Heather A
    Hamers, Timo
    Hamscher, Gerd
    Al-Anati, Lauy
    Stenius, Ulla
    Dervola, Kine-Susann
    Bogen, Inger-Lise
    Fonnum, Frode
    Andersson, Patrik L
    Schrenk, Dieter
    Halldin, Krister
    Håkansson, Helen
    Toxicological profile of ultrapure 2,2',3,4,4',5,5'-heptachlorbiphenyl (PCB 180) in adult rats.2014Inngår i: PloS one, ISSN 1932-6203, Vol. 9, nr 8, s. e104639-Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    PCB 180 is a persistent non-dioxin-like polychlorinated biphenyl (NDL-PCB) abundantly present in food and the environment. Risk characterization of NDL-PCBs is confounded by the presence of highly potent dioxin-like impurities. We used ultrapure PCB 180 to characterize its toxicity profile in a 28-day repeat dose toxicity study in young adult rats extended to cover endocrine and behavioral effects. Using a loading dose/maintenance dose regimen, groups of 5 males and 5 females were given total doses of 0, 3, 10, 30, 100, 300, 1000 or 1700 mg PCB 180/kg body weight by gavage. Dose-responses were analyzed using benchmark dose modeling based on dose and adipose tissue PCB concentrations. Body weight gain was retarded at 1700 mg/kg during loading dosing, but recovered thereafter. The most sensitive endpoint of toxicity that was used for risk characterization was altered open field behavior in females; i.e. increased activity and distance moved in the inner zone of an open field suggesting altered emotional responses to unfamiliar environment and impaired behavioral inhibition. Other dose-dependent changes included decreased serum thyroid hormones with associated histopathological changes, altered tissue retinoid levels, decreased hematocrit and hemoglobin, decreased follicle stimulating hormone and luteinizing hormone levels in males and increased expression of DNA damage markers in liver of females. Dose-dependent hypertrophy of zona fasciculata cells was observed in adrenals suggesting activation of cortex. There were gender differences in sensitivity and toxicity profiles were partly different in males and females. PCB 180 adipose tissue concentrations were clearly above the general human population levels, but close to the levels in highly exposed populations. The results demonstrate a distinct toxicological profile of PCB 180 with lack of dioxin-like properties required for assignment of WHO toxic equivalency factor. However, PCB 180 shares several toxicological targets with dioxin-like compounds emphasizing the potential for interactions.

  • 1775.
    Vingård, Eva
    Uppsala University, Department of Medical Sciences, Occupational and Environmental Medicine.
    Järvholm, Bengt ()
    Umeå universitet.
    Hogstedt, Christer ()
    Karolinska Institutet.
    Lindberg, Per ()
    Högskolan i Gävle, Akademin för hälsa och arbetsliv, Avdelningen för arbets- och folkhälsovetenskap, Arbetshälsovetenskap. Högskolan i Gävle, Centrum för belastningsskadeforskning.
    Karlsson, Thomas ()
    Högskolan i Gävle, Akademin för hälsa och arbetsliv, Avdelningen för arbets- och folkhälsovetenskap. Högskolan i Gävle, Centrum för belastningsskadeforskning.
    Helgesson, Magnus ()
    Uppsala University, Department of Medical Sciences, Occupational and Environmental Medicine.
    Johansson, Bo ()
    Uppsala University Hospital, Occupational and Environmental Medicine.
    Psykisk ohälsa, arbetsliv och sjukfrånvaro: en kunskapsöversikt2015Rapport (Fagfellevurdert)
    Abstract [sv]

    Kunskapsöversikten visar att det finns ett vetenskapligt samband mellan arbete, psykisk ohälsa och sjukskrivning. Riskfaktorer i arbetslivet är psykiskt ansträngande arbete, höga krav, låg kontroll, obalans mellan ansträngning och belöning, samt rollkonflikter. God kontroll och rättvisa ger minskad risk för sjukskrivning på grund av psykisk ohälsa.

    Det vetenskapliga underlaget för vilken åtgärd som är mest effektiv vid återgång i arbete efter en sjukskrivning på grund av psykisk ohälsa är svagt. Kunskaps- översikten visar dock tydligt att arbetsplatsen måste vara involverad för att medarbetaren ska komma tillbaka i arbete på ett bra sätt. Det finns flera vetenskapligt dokumenterade friskfaktorer i arbetet som kan minska risken för psykisk ohälsa och som bör användas i det förebyggande arbetet.

    Kunskapsöversikten visar också att effekten på den psykiska hälsan är likartad när kvinnor och män utsätts för samma faktorer i arbetet.

  • 1776. Virtanen, Marianna
    et al.
    Jokela, Markus
    Nyberg, Solja T.
    Madsen, Ida E. H.
    Lallukka, Tea
    Ahola, Kirsi
    Alfredsson, Lars
    Batty, G. David
    Bjorner, Jakob B.
    Borritz, Marianne
    Burr, Hermann
    Casini, Annalisa
    Clays, Els
    De Bacquer, Dirk
    Dragano, Nico
    Erbel, Raimund
    Ferrie, Jane E.
    Fransson, Eleonor I.
    Hamer, Mark
    Heikkil, Katriina
    Joeckel, Karl-Heinz
    Kittel, France
    Knutsson, Anders
    Koskenvuo, Markku
    Ladwig, Karl-Heinz
    Lunau, Thorsten
    Nielsen, Martin L.
    Nordin, Maria
    Umeå universitet, Samhällsvetenskapliga fakulteten, Institutionen för psykologi.
    Oksanen, Tuula
    Pejtersen, Jan H.
    Pentti, Jaana
    Rugulies, Reiner
    Salo, Paula
    Schupp, JRgen
    Siegrist, Johannes
    Singh-Manoux, Archana
    Steptoe, Andrew
    Suominen, Sakari B.
    Theorell, Tores
    Vahtera, Jussi
    Wagner, Gert G.
    Westerholm, Peter J. M.
    Westerlund, Hugo
    Kivimaki, Mika
    Long working hours and alcohol use: systematic review and meta-analysis of published studies and unpublished individual participant data2015Inngår i: BMJ (Clinical Research Edition), ISSN 0959-8138, Vol. 350, s. g7772-Artikkel, forskningsoversikt (Fagfellevurdert)
    Abstract [en]

    Objective To quantify the association between long working hours and alcohol use. Design Systematic review and meta-analysis of published studies and unpublished individual participant data. Data sources A systematic search of PubMed and Embase databases in April 2014 for published studies, supplemented with manual searches. Unpublished individual participant data were obtained from 27 additional studies. Review methods The search strategy was designed to retrieve cross sectional and prospective studies of the association between long working hours and alcohol use. Summary estimates were obtained with random effects meta-analysis. Sources of heterogeneity were examined with meta-regression. Results Cross sectional analysis was based on 61 studies representing 333 693 participants from 14 countries. Prospective analysis was based on 20 studies representing 100 602 participants from nine countries. The pooled maximum adjusted odds ratio for the association between long working hours and alcohol use was 1.11 (95% confidence interval 1.05 to 1.18) in the cross sectional analysis of published and unpublished data. Odds ratio of new onset risky alcohol use was 1.12 (1.04 to 1.20) in the analysis of prospective published and unpublished data. In the 18 studies with individual participant data it was possible to assess the European Union Working Time Directive, which recommends an upper limit of 48 hours a week. Odds ratios of new onset risky alcohol use for those working 49-54 hours and >= 55 hours a week were 1.13 (1.02 to 1.26; adjusted difference in incidence 0.8 percentage points) and 1.12 (1.01 to 1.25; adjusted difference in incidence 0.7 percentage points), respectively, compared with working standard 35-40 hours (incidence of new onset risky alcohol use 6.2%). There was no difference in these associations between men and women or by age or socioeconomic groups, geographical regions, sample type (population based v occupational cohort), prevalence of risky alcohol use in the cohort, or sample attrition rate. Conclusions Individuals whose working hours exceed standard recommendations are more likely to increase their alcohol use to levels that pose a health risk.

  • 1777.
    Virtanen, Marianna
    et al.
    Finnish Institute of Occupational Health, FI-00250 Helsinki, Finland .
    Nyberg, Solja
    Finnish Institute of Occupational Health, FI-00250 Helsinki, Finland .
    Batty, David
    Department of Epidemiology and Public Health, University College London, London, United Kingdom; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom.
    Jokela, Markus
    Institute of Behavioral Sciences, University of Helsinki, Helsinki, Finland .
    Heikkilä, Katriina
    Finnish Institute of Occupational Health, FI-00250 Helsinki, Finland .
    Fransson, Eleonor
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Avd. för naturvetenskap och biomedicin. Högskolan i Jönköping, Hälsohögskolan, HHJ. ADULT. Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Stress Research Institute, Stockholm University, Stockholm, Sweden .
    Alfredsson, Lars
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Centre for Occupational and Environmental Medicine, Stockholm County Council, Stockholm, Sweden .
    Bjorner, Jakob
    National Research Centre for the Working Environment, Copenhagen, Denmark .
    Borritz, Marianne
    Department of Occupational and Environmental Medicine, Bispebjerg University Hospital, Copenhagen, Denmark .
    Burr, Hermann
    Federal Institute for Occupational Safety and Health (BAuA), Berlin, Germany .
    Casini, Annalisa
    School of Public Health, Université Libre de Bruxelles, Brussels, Belgium .
    Clays, Els
    Department of Public Health, Ghent University, Ghent, Belgium .
    De Bacquer, Dirk
    Department of Public Health, Ghent University, Ghent, Belgium .
    Dragano, Nico
    Institute for Medical Sociology, Medical Faculty, University of Düsseldorf, Düsseldorf, Germany .
    Elovainio, Marko
    National Institute for Health and Welfare, Helsinki, Finland .
    Erbel, Raimund
    Department of Cardiology, West-German Heart Center Essen, University Duisburg-Essen, Essen, Germany .
    Ferrie, Jane
    Department of Epidemiology and Public Health, University College London, London, United Kingdom; School of Community and Social Medicine, University of Bristol, Bristol, United Kingdom .
    Hamer, Mark
    Department of Epidemiology and Public Health, University College London, London, United Kingdom .
    Jöckel, Karl-Heinz
    Institute for Medical Informatics, Biometry, and Epidemiology, University Duisburg-Essen, Germany .
    Kittel, France
    School of Public Health, Université Libre de Bruxelles, Brussels, Belgium .
    Knutsson, Anders
    Department of Health Sciences, Mid Sweden University, Sundsvall, Sweden .
    Koskenvuo, Markku
    Department of Public Health, University of Helsinki, Finland .
    Koskinen, Aki
    Finnish Institute of Occupational Health, FI-00250 Helsinki, Finland .
    Lunau, Thorsten
    Institute for Medical Sociology, Medical Faculty, University of Düsseldorf, Düsseldorf, Germany .
    Madsen, Ida
    National Research Centre for the Working Environment, Copenhagen, Denmark .
    Nielsen, Martin
    Department of Occupational and Environmental Medicine, Bispebjerg University Hospital, Copenhagen, Denmark .
    Nordin, Maria
    Department of Psychology, Umeå University, Umeå, Sweden .
    Oksanen, Tuula
    Finnish Institute of Occupational Health, FI-00250 Helsinki, Finland .
    Pahkin, Krista
    Department of Epidemiology and Public Health, University College London, London, United Kingdom .
    Pejtersen, Jan
    Danish National Centre for Social Research, Copenhagen, Denmark .
    Pentti, Jaana
    Finnish Institute of Occupational Health, FI-00250 Helsinki, Finland .
    Rugulies, Reiner
    National Research Centre for the Working Environment, Copenhagen, Denmark; Department of Public Health, University of Copenhagen, Copenhagen, Denmark .
    Salo, Paula
    Finnish Institute of Occupational Health, FI-00250 Helsinki, Finland; Department of Psychology, University of Turku, Turku, Finland .
    Shipley, Martin
    Department of Epidemiology and Public Health, University College London, London, United Kingdom .
    Siegrist, Johannes
    Institute for Medical Sociology, Medical Faculty, University of Düsseldorf, Düsseldorf, Germany .
    Steptoe, Andrew
    Department of Epidemiology and Public Health, University College London, London, United Kingdom .
    Suominen, Sakari
    Folkhälsan Research Center, Helsinki, Finland; Department of Public Health, University of Turku, Finland; Nordic School of Public Health, Gothenburg, Sweden .
    Theorell, Töres
    Stress Research Institute, Stockholm University, Stockholm, Sweden .
    Toppinen-Tanner, Salla
    Finnish Institute of Occupational Health, FI-00250 Helsinki, Finland .
    Väänänen, Ari
    Finnish Institute of Occupational Health, FI-00250 Helsinki, Finland .
    Vahtera, Jussi
    Finnish Institute of Occupational Health, FI-00250 Helsinki, Finland; Department of Public Health, University of Turku, Finland; Turku University Hospital, Turku, Finland .
    Westerholm, Peter
    Occupational and Environmental Medicine, Uppsala University, Uppsala, Sweden .
    Westerlund, Hugo
    Stress Research Institute, Stockholm University, Stockholm, Sweden .
    Slopen, Natalie
    Department of Society, Human Development and Health, Harvard School of Public Health, Boston, MA, United States; Center for the Developing Child, Harvard University, Cambridge, MA, United States .
    Kawachi, Ichiro
    Department of Society, Human Development and Health, Harvard School of Public Health, Boston, MA, United States .
    Singh-Manoux, Archana
    Department of Epidemiology and Public Health, University College London, London, United Kingdom; Inserm U1018, Centre for Research in Epidemiology and Population Health, Villejuif, France .
    Kivimäki, Mika
    Finnish Institute of Occupational Health, FI-00250 Helsinki, Finland; Department of Epidemiology and Public Health, University College London, London, United Kingdom; Institute of Behavioral Sciences, University of Helsinki, Helsinki, Finland.
    Perceived job insecurity as a risk factor for incident coronary heart disease: systematic review and meta-analysis2013Inngår i: BMJ. British Medical Journal, E-ISSN 1756-1833, Vol. 347, nr 7921, artikkel-id f4746Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objective To determine the association between self reported job insecurity and incident coronary heart disease.

    Design A meta-analysis combining individual level data from a collaborative consortium and published studies identified by a systematic review.

    Data sources We obtained individual level data from 13 cohort studies participating in the Individual-Participant-Data Meta-analysis in Working Populations Consortium. Four published prospective cohort studies were identified by searches of Medline (to August 2012) and Embase databases (to October 2012), supplemented by manual searches.

    Review methods Prospective cohort studies that reported risk estimates for clinically verified incident coronary heart disease by the level of self reported job insecurity. Two independent reviewers extracted published data. Summary estimates of association were obtained using random effects models.

    Results The literature search yielded four cohort studies. Together with 13 cohort studies with individual participant data, the meta-analysis comprised up to 174 438 participants with a mean follow-up of 9.7 years and 1892 incident cases of coronary heart disease. Age adjusted relative risk of high versus low job insecurity was 1.32 (95% confidence interval 1.09 to 1.59). The relative risk of job insecurity adjusted for sociodemographic and risk factors was 1.19 (1.00 to 1.42). There was no evidence of significant differences in this association by sex, age (<50 v ≥50 years), national unemployment rate, welfare regime, or job insecurity measure.

    Conclusions The modest association between perceived job insecurity and incident coronary heart disease is partly attributable to poorer socioeconomic circumstances and less favourable risk factor profiles among people with job insecurity.

  • 1778. Virtanen, Marianna
    et al.
    Nyberg, Solja T
    Batty, G David
    Jokela, Markus
    Heikkilä, Katriina
    Fransson, Eleonor I
    Alfredsson, Lars
    Bjorner, Jakob B
    Borritz, Marianne
    Burr, Hermann
    Casini, Annalisa
    Clays, Els
    De Bacquer, Dirk
    Dragano, Nico
    Elovainio, Marko
    Erbel, Raimund
    Ferrie, Jane E
    Hamer, Mark
    Jöckel, Karl-Heinz
    Kittel, France
    Knutsson, Anders
    Koskenvuo, Markku
    Koskinen, Aki
    Lunau, Thorsten
    Madsen, Ida E H
    Nielsen, Martin L
    Nordin, Maria
    Oksanen, Tuula
    Pahkin, Krista
    Pejtersen, Jan H
    Pentti, Jaana
    Rugulies, Reiner
    Salo, Paula
    Shipley, Martin J
    Siegrist, Johannes
    Steptoe, Andrew
    Suominen, Sakari B
    Theorell, Töres
    Toppinen-Tanner, Salla
    Väänänen, Ari
    Vahtera, Jussi
    Westerholm, Peter J M
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Arbets- och miljömedicin.
    Westerlund, Hugo
    Slopen, Natalie
    Kawachi, Ichiro
    Singh-Manoux, Archana
    Kivimäki, Mika
    Perceived job insecurity as a risk factor for incident coronary heart disease: systematic review and meta-analysis.2013Inngår i: BMJ (Clinical research ed.), ISSN 1756-1833, Vol. 347, s. f4746-Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    OBJECTIVE: To determine the association between self reported job insecurity and incident coronary heart disease.

    DESIGN: A meta-analysis combining individual level data from a collaborative consortium and published studies identified by a systematic review.

    DATA SOURCES: We obtained individual level data from 13 cohort studies participating in the Individual-Participant-Data Meta-analysis in Working Populations Consortium. Four published prospective cohort studies were identified by searches of Medline (to August 2012) and Embase databases (to October 2012), supplemented by manual searches.

    REVIEW METHODS: Prospective cohort studies that reported risk estimates for clinically verified incident coronary heart disease by the level of self reported job insecurity. Two independent reviewers extracted published data. Summary estimates of association were obtained using random effects models.

    RESULTS: The literature search yielded four cohort studies. Together with 13 cohort studies with individual participant data, the meta-analysis comprised up to 174,438 participants with a mean follow-up of 9.7 years and 1892 incident cases of coronary heart disease. Age adjusted relative risk of high versus low job insecurity was 1.32 (95% confidence interval 1.09 to 1.59). The relative risk of job insecurity adjusted for sociodemographic and risk factors was 1.19 (1.00 to 1.42). There was no evidence of significant differences in this association by sex, age (<50 v ≥ 50 years), national unemployment rate, welfare regime, or job insecurity measure.

    CONCLUSIONS: The modest association between perceived job insecurity and incident coronary heart disease is partly attributable to poorer socioeconomic circumstances and less favourable risk factor profiles among people with job insecurity.

  • 1779. Virtanen, Marianna
    et al.
    Nyberg, Solja T.
    Batty, G. David
    Jokela, Markus
    Heikkilä, Katriina
    Fransson, Eleonor I.
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Stressforskningsinstitutet.
    Alfredsson, Lars
    Bjorner, Jakob B.
    Borritz, Marianne
    Burr, Hermann
    Casini, Annalisa
    Clays, Els
    De Bacquer, Dirk
    Dragano, Nico
    Elovainio, Marko
    Erbel, Raimund
    Ferrie, Jane E.
    Hamer, Mark
    Jöckel, Karl-Heinz
    Kittel, France
    Knutsson, Anders
    Koskenvuo, Markku
    Koskinen, Aki
    Lunau, Thorsten
    Madsen, Ida E. H.
    Nielsen, Martin L.
    Nordin, Maria
    Oksanen, Tuula
    Pahkin, Krista
    Pejtersen, Jan H.
    Pentti, Jaana
    Rugulies, Reiner
    Salo, Paula
    Shipley, Martin J.
    Siegrist, Johannes
    Steptoe, Andrew
    Suominen, Sakari B.
    Theorell, Töres
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Stressforskningsinstitutet.
    Toppinen-Tanner, Salla
    Väänänen, Ari
    Vahtera, Jussi
    Westerholm, Peter J. M.
    Westerlund, Hugo
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Stressforskningsinstitutet.
    Slopen, Natalie
    Kawachi, Ichiro
    Singh-Manoux, Archana
    Kivimäki, Mika
    Perceived job insecurity as a risk factor for incident coronary heart disease: systematic review and meta-analysis2013Inngår i: BMJ. British Medical Journal, E-ISSN 1756-1833, Vol. 347, artikkel-id f4746Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objective To determine the association between self reported job insecurity and incident coronary heart disease.

    Design A meta-analysis combining individual level data from a collaborative consortium and published studies identified by a systematic review.

    Data sources We obtained individual level data from 13 cohort studies participating in the Individual-Participant-Data Meta-analysis in Working Populations Consortium. Four published prospective cohort studies were identified by searches of Medline (to August 2012) and Embase databases (to October 2012), supplemented by manual searches.

    Review methods Prospective cohort studies that reported risk estimates for clinically verified incident coronary heart disease by the level of self reported job insecurity. Two independent reviewers extracted published data. Summary estimates of association were obtained using random effects models.

    Results The literature search yielded four cohort studies. Together with 13 cohort studies with individual participant data, the meta-analysis comprised up to 174 438 participants with a mean follow-up of 9.7 years and 1892 incident cases of coronary heart disease. Age adjusted relative risk of high versus low job insecurity was 1.32 (95% confidence interval 1.09 to 1.59). The relative risk of job insecurity adjusted for sociodemographic and risk factors was 1.19 (1.00 to 1.42). There was no evidence of significant differences in this association by sex, age (<50 v >= 50 years), national unemployment rate, welfare regime, or job insecurity measure.

    Conclusions The modest association between perceived job insecurity and incident coronary heart disease is partly attributable to poorer socioeconomic circumstances and less favourable risk factor profiles among people with job insecurity.

  • 1780.
    Virtanen, Pekka
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin.
    Lipiainen, Liudmila
    Hammarström, Anne
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin.
    Janlert, Urban
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin.
    Saloniemi, Antti
    Nummi, Tapio
    Tracks of labour market attachment in early middle age: A trajectory analysis over 12 years2011Inngår i: ADVANCES IN LIFE COURSE RESEARCH, ISSN 1040-2608, Vol. 16, nr 2, s. 55-64Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The predominant aim of this study was to contribute to the methodology in research on work trajectories as essential element of the life course in adulthood. Data on the labour market attachment of a population cohort (n = 1005) from age 30 to age 42 were collected with a questionnaire. We applied trajectory analysis in order to define different attachment tracks. According to the information criteria, six tracks were discerned: in addition to those who are in permanent employment (high-level attachment), in temporary employment (medium-level attachment) and out of work (poor-level attachment) throughout early middle age, we were able to define subgroups that move from temporary to permanent employment (strengthening attachment) or vice versa (weakening attachment), and also some who enter working life and attain permanent employment at a relatively high age (delayed attachment). On average, attachment was high and strengthened with time, indicating that no major de-standardization of employment occurred during the follow-up years (1995-2007) in the studied labour market and age cohort. Given longitudinal data with at least ordinal scale variables, the applied trajectory analysis may be recommended as a "method of choice" in clustering the diverse and non-standard work-life courses into a meaningful set of tracks. (C) 2011 Elsevier Ltd. All rights reserved.

  • 1781.
    Virtanen, Pekka
    et al.
    Umeå universitet, Institutionen för folkhälsa och klinisk medicin.
    Lipiainen, Liudmila
    Hammarström, Anne
    Umeå universitet, Institutionen för folkhälsa och klinisk medicin.
    Janlert, Urban
    Umeå universitet, Institutionen för folkhälsa och klinisk medicin.
    Saloniemi, Antti
    Nummi, Tapio
    Tracks of labour market attachment in early middle age: A trajectory analysis over 12 years2011Inngår i: ADVANCES IN LIFE COURSE RESEARCH, ISSN 1040-2608, Vol. 16, nr 2, s. 55-64Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The predominant aim of this study was to contribute to the methodology in research on work trajectories as essential element of the life course in adulthood. Data on the labour market attachment of a population cohort (n = 1005) from age 30 to age 42 were collected with a questionnaire. We applied trajectory analysis in order to define different attachment tracks. According to the information criteria, six tracks were discerned: in addition to those who are in permanent employment (high-level attachment), in temporary employment (medium-level attachment) and out of work (poor-level attachment) throughout early middle age, we were able to define subgroups that move from temporary to permanent employment (strengthening attachment) or vice versa (weakening attachment), and also some who enter working life and attain permanent employment at a relatively high age (delayed attachment). On average, attachment was high and strengthened with time, indicating that no major de-standardization of employment occurred during the follow-up years (1995-2007) in the studied labour market and age cohort. Given longitudinal data with at least ordinal scale variables, the applied trajectory analysis may be recommended as a "method of choice" in clustering the diverse and non-standard work-life courses into a meaningful set of tracks. (C) 2011 Elsevier Ltd. All rights reserved.

  • 1782.
    Virtanen, Pekka
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Socialmedicin. Institute for Advanced Social Research and School of Health Sciences, University of Tampere, Tampere, Finland.
    Nummi, Tapio
    Lintonen, Tomi
    Westerlund, Hugo
    Hägglöf, Bruno
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin.
    Hammarström, Anne
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Allmänmedicin.
    Mental health in adolescence as determinant of alcohol consumption trajectories in the Northern Swedish Cohort2015Inngår i: International Journal of Public Health, ISSN 1661-8556, E-ISSN 1661-8564, Vol. 63, nr 3, s. 335-342Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The study aimed to analyze whether poor mental health in adolescence predicts heavy alcohol consumption over the long term. Alcohol consumption in the population cohort (n = 1010) was surveyed at the ages of 16, 18, 21, 30 and 42. Utilizing latent class growth analysis, six consumption trajectories ranging from 'Late Onset Low' to 'Early Onset High' were defined and analyzed with respect to internalization (depressiveness and anxiousness) and externalization (truancy and vandalism) at age 16. Poor mental health predicted the Early Onset High trajectory (risk ratios in relation to the compliant trajectory 3.59 for anxiousness, 2.85 for depressiveness, 5.69 for truancy and 7.75 for externalized vandalism). Moreover, significant associations were found for the Early Onset Moderate and Early Onset Low trajectories. This is the first study to show an association between internalized mental health problems in adolescence and lifelong heavy drinking. The study also confirmed a strong association between externalized behavior and heavy drinking, indicating a need of preventive measures in this group. Nevertheless, the analyses demonstrated that most teenagers with mental health problems continue along a reasonable drinking trajectory.

  • 1783.
    Virtanen, Pekka
    et al.
    Umeå universitet, Socialmedicin.
    Nummi, Tapio
    Lintonen, Tomi
    Westerlund, Hugo
    Hägglöf, Bruno
    Umeå universitet, Institutionen för folkhälsa och klinisk medicin.
    Hammarström, Anne
    Umeå universitet, Allmänmedicin.
    Mental health in adolescence as determinant of alcohol consumption trajectories in the Northern Swedish Cohort2015Inngår i: International Journal of Public Health, ISSN 1661-8556, E-ISSN 1661-8564, Vol. 63, nr 3, s. 335-342Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The study aimed to analyze whether poor mental health in adolescence predicts heavy alcohol consumption over the long term. Alcohol consumption in the population cohort (n = 1010) was surveyed at the ages of 16, 18, 21, 30 and 42. Utilizing latent class growth analysis, six consumption trajectories ranging from 'Late Onset Low' to 'Early Onset High' were defined and analyzed with respect to internalization (depressiveness and anxiousness) and externalization (truancy and vandalism) at age 16. Poor mental health predicted the Early Onset High trajectory (risk ratios in relation to the compliant trajectory 3.59 for anxiousness, 2.85 for depressiveness, 5.69 for truancy and 7.75 for externalized vandalism). Moreover, significant associations were found for the Early Onset Moderate and Early Onset Low trajectories. This is the first study to show an association between internalized mental health problems in adolescence and lifelong heavy drinking. The study also confirmed a strong association between externalized behavior and heavy drinking, indicating a need of preventive measures in this group. Nevertheless, the analyses demonstrated that most teenagers with mental health problems continue along a reasonable drinking trajectory.

  • 1784.
    Vogel, Kjerstin
    et al.
    KTH, Skolan för teknik och hälsa (STH), Hälso- och systemvetenskap, Ergonomi.
    Eklund, Jörgen
    KTH, Skolan för teknik och hälsa (STH), Hälso- och systemvetenskap, Ergonomi.
    On physiological demands and sustainability in meat cutting2014Inngår i: Ergonomics, ISSN 0014-0139, E-ISSN 1366-5847, Vol. 58, nr 3, s. 463-479Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Meat cutters' work has been investigated by several researchers. However, knowledge about the physiological demands of meat cutting is almost lacking. The aim of this explorative study was to assess physiological demands in meat cutting, to compare them with International Labour Organization (ILO) recommendations for acceptable workload and to discuss the findings in relation to individual and work-related factors. In accordance with the ILO recommendations, work was categorised as sustainable or non-sustainable based on critical relative aerobic strain (RAS) levels. Twenty-one beef and pork cutters participated in the study, which included workload measurements, assessment of workplace and individual factors. Thirteen meat cutters were categorised as having non-sustainable and eight as having sustainable work. Results suggest that the workload is higher in beef cutting than in pork cutting, and that longer work experience is related to lower RAS. Other factors contributing to the physical workload are discussed.

    Practitioner Summary: Meat-cutting work may exceed recommended physical workload levels. Beef cutting is physically more demanding than pork cutting. Furthermore, factors such as years in the profession, knife sharpness, work pace, wage system, working technique, maximum oxygen uptake level and muscular strength should be considered when planning actions regarding the workload for meat cutters.

  • 1785. Vogt, Hartmut
    et al.
    Bråbäck, Lennart
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Yrkes- och miljömedicin.
    Kling, Anna-Maria
    Grünewald, Maria
    Nilsson, Lennart
    Pertussis immunization in infancy and adolescent asthma medication.2014Inngår i: Pediatrics, ISSN 1098-4275, Vol. 134, nr 4, s. 721-728Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    BACKGROUND AND OBJECTIVES: Childhood immunization may influence the development of asthma, possibly due to lack of infections or a shift in the T-helper cell type 1/T-helper cell type 2/regulatory T cells balance. We therefore investigated whether pertussis immunization in infancy is associated with asthma medication in adolescence.

    METHODS: After 14 years of no general pertussis vaccination, almost 82 000 Swedish children were immunized for pertussis in a vaccination trial between June 1, 1993, and June 30, 1994. In a follow-up analysis of almost 80 000 children, their data were compared with those of ∼100 000 nonvaccinated children, born during a 5-month period before and a 7-month period after the vaccination trial. Data for the main outcome variable (ie, dispensed prescribed asthma medication for each individual in the cohort during 2008-2010) were obtained from the national prescription database. Multivariate regression models were used to calculate the effect size of vaccination on dispensed asthma medication (odds ratios [OR], 95% confidence intervals [CI]). Approaches similar to intention-to-treat and per-protocol methods were used.

    RESULTS: The prevalence rates of various asthma medications for study patients at 15 years of age differed between 4.6% and 7.0%. The crude ORs for any asthma medication and antiinflammatory treatment in pertussis-vaccinated children after intention-to-treat analysis were 0.97 (95% CI: 0.93-1.00) and 0.94 (95% CI: 0.90-0.98), respectively. Corresponding adjusted ORs were 0.99 (95% CI: 0.95-1.03) and 0.97 (95% CI: 0.92-1.01). Similar ORs were found after per-protocol analysis.

    CONCLUSIONS: Pertussis immunization in infancy does not increase the risk of asthma medication use in adolescents. Our study presents evidence that pertussis immunization in early childhood can be considered safe with respect to long-term development of asthma.

  • 1786.
    von Thiele Schwarz, Ulrica
    et al.
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Psykologiska institutionen.
    Hasson, Henna
    Effects of worksite health interventions involving reduced work hours and physical exercise on sickness absence costs2012Inngår i: Journal of Occupational and Environmental Medicine, ISSN 1076-2752, E-ISSN 1536-5948, Vol. 54, nr 5, s. 538-544Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objective: To investigate the effects of physical exercise during work hours (PE) and reduced work hours (RWH) on direct and indirect costs associated with sickness absence (SA). Methods: Sickness absence and related costs at six workplaces, matched and randomized to three conditions (PE, RWH, and referents), were retrieved from company records and/or estimated using salary conversion methods or value-added equations on the basis of interview data. Results: Although SA days decreased in all conditions (PE, 11.4%; RWH, 4.9%; referents, 15.9%), costs were reduced in the PE (22.2%) and RWH (4.9%) conditions but not among referents (10.2% increase). Conclusions: Worksite health interventions may generate savings in SA costs. Costs may not be linear to changes in SA days. Combing the friction method with indirect cost estimates on the basis of value-added productivity may help illuminate both direct and indirect SA costs.

  • 1787. von Thiele Schwarz, Ulrica
    et al.
    Hasson, Henna
    Tafvelin, Susanne
    Umeå universitet, Samhällsvetenskapliga fakulteten, Institutionen för psykologi. Medical Management Centre, Department of Learning, Informatics, Management and Ethics, Karolinska Institutet, Stockholm, Sweden.
    Leadership training as an occupational health intervention: improved safety and sustained productivity2016Inngår i: Safety Science, ISSN 0925-7535, E-ISSN 1879-1042, Vol. 81, s. 35-45Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The safety climate in an organization is determined by how managers balance the relative importance of safety and productivity. This gives leaders a central role in safety in an organization, and from this follows that leadership training may improve safety. Transformational leadership may be one important component but may need to be combined with positive control leadership behaviors. Leadership training that combines transformational leadership and applied behavior analysis may be a way to achieve this. Purpose: The study evaluates changes in safety climate and productivity among employees whose leaders (n = 76) took part in a leadership training program combining transformational leadership and applied behavior analysis. Changes in managers' ratings of transformational leadership, contingent rewards, Management-by-Exceptions Active (MBEA) and safety self-efficacy were evaluated. Moreover, we compare whether the training has differentiated effects on safety depending on managers' specific focus on improvements in: (1) safety, (2) productivity or (3) general leadership. Result: Safety climate improved over time, while self-rated productivity remained unchanged. As hypothesized, transformational leadership, contingent rewards and safety self-efficacy as proxies for positive control behaviors increased while MBEA, a negative control behavior, decreased. Managers focusing on general leadership skills showed greater improvement in safety climate expectations. Conclusions: Training leaders in both transformational leadership and applied behavior analysis is related to improvements in leadership and safety. There is no added benefit of focusing specifically on safety or productivity.

  • 1788. von Thiele Schwarz, Ulrica
    et al.
    Sjoberg, Anders
    Hasson, Henna
    Tafvelin, Susanne
    Umeå universitet, Samhällsvetenskapliga fakulteten, Institutionen för psykologi.
    Measuring Self-Rated Productivity Factor Structure and Variance Component Analysis of the Health and Work Questionnaire2014Inngår i: Journal of Occupational and Environmental Medicine, ISSN 1076-2752, E-ISSN 1536-5948, Vol. 56, nr 12, s. 1302-1307Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objective: To test the factor structure and variance components of the productivity subscales of the Health and Work Questionnaire (HWQ). Methods: A total of 272 individuals from one company answered the HWQ scale, including three dimensions (efficiency, quality, and quantity) that the respondent rated from three perspectives: their own, their supervisor's, and their coworkers'. A confirmatory factor analysis was performed, and common and unique variance components evaluated. Results: A common factor explained 81% of the variance (reliability 0.95). All dimensions and rater perspectives contributed with unique variance. The final model provided a perfect fit to the data. Conclusions: Efficiency, quality, and quantity and three rater perspectives are valid parts of the self-rated productivity measurement model, but with a large common factor. Thus, the HWQ can be analyzed either as one factor or by extracting the unique variance for each subdimension.

  • 1789.
    von Thiele Schwarz, Ulrica
    et al.
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Psykologiska institutionen. Karolinska Institutet, Sweden.
    Sjöberg, Anders
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Psykologiska institutionen.
    Hasson, Henna
    Tafvelin, Susanne
    Measuring Self-Rated Productivity Factor Structure and Variance Component Analysis of the Health and Work Questionnaire2014Inngår i: Journal of Occupational and Environmental Medicine, ISSN 1076-2752, E-ISSN 1536-5948, Vol. 56, nr 12, s. 1302-1307Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objective: To test the factor structure and variance components of the productivity subscales of the Health and Work Questionnaire (HWQ). Methods: A total of 272 individuals from one company answered the HWQ scale, including three dimensions (efficiency, quality, and quantity) that the respondent rated from three perspectives: their own, their supervisor's, and their coworkers'. A confirmatory factor analysis was performed, and common and unique variance components evaluated. Results: A common factor explained 81% of the variance (reliability 0.95). All dimensions and rater perspectives contributed with unique variance. The final model provided a perfect fit to the data. Conclusions: Efficiency, quality, and quantity and three rater perspectives are valid parts of the self-rated productivity measurement model, but with a large common factor. Thus, the HWQ can be analyzed either as one factor or by extracting the unique variance for each subdimension.

  • 1790. Vrethem, M
    et al.
    Lindh, J
    Tondel, Martin
    Occupational and Environmental Medicine, Department of Public Health and Community Medicine, University of Gothenburg, Gothenburg, Sweden.
    Persson, B
    Dahle, C
    IgA antibodies against tissue transglutaminase, endomysium and gliadin in idiopathic polyneuropathy2013Inngår i: Acta Neurologica Scandinavica, ISSN 0001-6314, E-ISSN 1600-0404, Vol. 127, nr 2, s. 109-115Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    OBJECTIVES:

    To study the prevalence of antibodies of IgA class against tissue transglutaminase (tTG), endomysium (EMA) and gliadin (AGA) in patients with chronic idiopathic axonal polyneuropathy (CIAP) and to characterize the patients clinically and neurophysiologically.

    METHODS:

    Of 182 patients, 126 patients agreed to blood sampling. Sera were analysed by ELISAs detecting anti-tTG and AGA, whereas EMA was analysed by indirect immunofluorescence (IF) microscopy. Gastrointestinal symptoms were assessed by data from medical records and patient interviews.

    RESULTS:

    Nine of 126 patients (7%) were seropositive in at least one test (five with positive anti-tTG and/or EMA and four with positive AGA only). One patient with elevated levels of all specificities had laboratory signs of malabsorption and gastrointestinal complaints with abdominal pain and diarrhoea.

    CONCLUSIONS:

    Elevated levels of IgA-AGA were slightly more frequent in patients with CIAP (4%) compared to 2.5% in 1866 healthy blood donors. Highly specific serological markers indicative of coeliac disease (CD) (anti-tTG and EMA) were somewhat more common in our patients with CIAP (4%) than expected from normal reference values and from studies of the prevalence of CD in the general population. Even though these findings may indicate a relationship, the aetiological importance is unclear.

  • 1791.
    Vähäsarja, Niko
    et al.
    Karolinska Institutet, Division of Dental Biomaterials and Cariology, Department of Dental Medicine, Stockholm, Sweden.
    Montgomery, Scott
    Örebro universitet, Institutionen för hälsovetenskap och medicin. Clinical Epidemiology Unit, Karolinska Institutet, Department of Medicine, Stockholm, Sweden; Clinical Epidemiology and Biostatistics, Örebro University Hospital, Örebro, Sweden; Department of Epidemiology and Public Health, University College London, London, United Kingdom.
    Sandborgh-Englund, Gunilla
    Karolinska Institutet, Division of Dental Biomaterials and Cariology, Department of Dental Medicine, Stockholm, Sweden.
    Ekbom, Anders
    Clinical Epidemiology Unit, Karolinska Institutet, Department of Medicine, Stockholm, Sweden.
    Ekstrand, Jan
    Clinical Epidemiology Unit, Karolinska Institutet, Department of Medicine, Stockholm, Sweden.
    Näsman, Peggy
    Karolinska Institutet, Division of Dental Biomaterials and Cariology, Department of Dental Medicine, Stockholm, Sweden.
    Naimi-Akbar, Aron
    Karolinska Institutet, Division of Dental Biomaterials and Cariology, Department of Dental Medicine, Stockholm, Sweden.
    Neurological disease or intellectual disability among sons of female Swedish dental personnel2016Inngår i: Journal of Perinatal Medicine, ISSN 0300-5577, E-ISSN 1619-3997, Vol. 44, nr 4, s. 453-460Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objective: Prenatal exposure to elemental mercury may be a potential hazard for the offspring of female dental personnel working with dental amalgam. The aim of this study was to investigate whether potential in utero exposure to mercury might have affected the development of nervous system of the sons of Swedish female dental personnel leading to an increased risk of neurological disease or intellectual disability.

    Material and methods: We used national Swedish registers to investigate risks for diseases potentially related to adverse effects on neurodevelopment. Sons of female dentists (n=1690) and dental nurses (n=10,420) were compared with cohorts consisting of sons of other female healthcare personnel. Due to changes in mercury exposure in dentistry during the study period, analyses were stratified by decade of birth. Hazard ratios (HRs) were calculated using Cox proportional hazard models.

    Results: We found no elevated risk for neurological disease, epilepsy or intellectual disability among the sons of dental personnel during any of the decades studied. HRs for neurological disease among the dental nurse cohort were even below 1.00 during the 1970s and 1980s. A low number of events resulted in uncertainty regarding results in the dentist cohort.

    Conclusions: We did not find any support for the hypothesis that mercury exposure in Swedish dentistry during the 1960s, 1970s or 1980s had any effect on the incidence of neurological disease or intellectual disability among the sons of female dental personnel. Our results imply that current use of dental amalgam should not represent an elevated risk for neurological disease or intellectual disability among the offspring of dental personnel.

  • 1792.
    Wadman, Cecilia
    et al.
    Department for Health Behaviours, Swedish National Institute of Public Health, Östersund, Sweden.
    Kjellberg, Anders
    Högskolan i Gävle, Institutionen för teknik och byggd miljö, Ämnesavdelningen för inomhusmiljö.
    The role of the affective stress response as a mediator for the effect of psychosocial risk factors on musculoskeletal complaints - Part 2: Hospital workers2007Inngår i: International Journal of Industrial Ergonomics, ISSN 0169-8141, E-ISSN 1872-8219, Vol. 37, nr 5, s. 395-403Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    This cross-sectional study of 267 hospital workers from different professions tested the hypothesis that affective stress responses mediate the effects of the psychosocial work environment on musculoskeletal complaints (MSCs). Self-reported psychosocial conditions,ergonomic workloads, affective stress and energy responses, and MSCs were analysed with a series of logistic regression analyses. The psychosocial variables were strongly related to stress and energy, and stress was related to MSCs. Neck and shoulder complaints were more common in the group with high demands and low skill discretion. This was the only significant relation between psychosocial variables and MSCs that was not explained by their confounding with ergonomic workload. However, controlling for stress did not substantially reduce or reduce this interaction effect, which would have been the case if it had been mediated (completely or partially) by stress.

  • 1793. Wagman, Petra
    et al.
    Nordin, Maria
    Umeå universitet, Samhällsvetenskapliga fakulteten, Institutionen för psykologi. Stress Research Institute, Stockholm University, Stockholm, Sweden.
    Alfredsson, Lars
    Westerholm, Peter J. M.
    Fransson, Eleonor I.
    Domestic work division and satisfaction in cohabiting adults: associations with life satisfaction and self-rated health2017Inngår i: Scandinavian Journal of Occupational Therapy, ISSN 1103-8128, E-ISSN 1651-2014, Vol. 24, nr 1, s. 24-31Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: The amount and perception of domestic work may affect satisfaction with everyday life, but further knowledge is needed about the relationship between domestic work division and health and well-being. Aim: To describe the division of, and satisfaction with, domestic work and responsibility for home/family in adults living with a partner. A further aim was to investigate the associations between these aspects and self-rated life satisfaction and health. Method: Data from the Work, Lipids and Fibrinogen survey collected 2009 were used, comprising 4924 participants living with a partner. Data were analyzed using logistic regression. Results: The majority shared domestic work and responsibility for home/family equally with their partner. However, more women conducted the majority of the domestic work and were less satisfied with its division. When both division and satisfaction with division was included in the analysis, solely satisfaction with the division and the responsibility were associated with higher odds for good life satisfaction. Regarding health, higher odds for good self-rated health were seen in those who were satisfied with their division of responsibility. Conclusion and significance: The results highlight the importance of taking into account not solely the actual division of domestic work but also the satisfaction with it.

  • 1794.
    Wahlberg, Anna
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Internationell mödra- och barnhälsovård (IMCH).
    Johnsdotter, Sara
    Faculty of Health and Society, Malmö University, Sweden.
    Ekholm Selling, Katarina
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Internationell mödra- och barnhälsovård (IMCH).
    Källestål, Carina
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Internationell mödra- och barnhälsovård (IMCH).
    Essén, Birgitta
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Internationell mödra- och barnhälsovård (IMCH).
    Factors associated with the support of pricking (female genital cutting type IV) among Somali immigrants – a cross-sectional study in Sweden2017Inngår i: Reproductive Health, ISSN 1742-4755, E-ISSN 1742-4755, Vol. 14, artikkel-id 92Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: Pricking, classified as female genital cutting (FGC) type IV by the World Health Organization, is an under-researched area gaining momentum among diaspora communities. Our aim was to explore factors associated with being supportive of pricking among Somalis in Sweden.

    Methods: In a cross-sectional design, attitudes and knowledge regarding FGC, and measures of socioeconomic status, acculturation, and social capital, were assessed by a 49-item questionnaire in four municipalities in Sweden. Data were collected in 2015 from 648 Somali men and women, >= 18 years old, of which 113 supported the continuation of pricking. Logistic regression was used for the analysis.

    Results: Those more likely to support the continuation of pricking were older, originally from rural areas, and newly arrived in Sweden. Further, those who reported that they thought pricking was: acceptable, according to their religion (aOR: 10.59, 95% CI: 5.44-20.62); not a violation of children's rights (aOR: 2.86, 95% CI: 1.46-5.61); and did not cause long-term health complications (aOR: 5.52, 95% CI: 2.25-13.52) had higher odds of supporting pricking. Religion was strongly associated with the support of pricking among both genders. However, for men, children's rights and the definition of pricking as FGC or not were important aspects in how they viewed pricking, while, for women, health complications and respectability were important.

    Conclusions: Values known to be associated with FGC in general are also related to pricking. Hence, there seems to be a change in what types of FGC are supported rather than in their perceived values.

  • 1795.
    Wahlström, Jens
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Yrkes- och miljömedicin.
    Bergsten, Eva
    Trask, Catherine
    Mathiassen, Svend Erik
    Jackson, Jennie
    Forsman, Mikael
    Full-Shift Trunk and Upper Arm Postures and Movements Among Aircraft Baggage Handlers2016Inngår i: Annals of Occupational Hygiene, ISSN 0003-4878, E-ISSN 1475-3162, Vol. 60, nr 8, s. 977-90Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    OBJECTIVES: The present study assessed full-shift trunk and upper arm postural exposure amplitudes, frequencies, and durations among Swedish airport baggage handlers and aimed to determine whether exposures differ between workers at the ramp (loading and unloading aircraft) and baggage sorting areas.

    METHODS: Trunk and upper arm postures were measured using inclinometers during three full work shifts on each of 27 male baggage handlers working at a large Swedish airport. Sixteen of the baggage handlers worked on the ramp and 11 in the sorting area. Variables summarizing postures and movements were calculated, and mean values and variance components between subjects and within subject (between days) were estimated using restricted maximum likelihood algorithms in a one-way random effect model.

    RESULTS: In total, data from 79 full shifts (651h) were collected with a mean recording time of 495min per shift (range 319-632). On average, baggage handlers worked with the right and left arm elevated >60° for 6.4% and 6.3% of the total workday, respectively. The 90th percentile trunk forward projection (FP) was 34.1°, and the 50th percentile trunk movement velocity was 8° s(-1). For most trunk (FP) and upper arm exposure variables, between-subject variability was considerable, suggesting that the flight baggage handlers were not a homogeneously exposed group. A notable between-days variability pointed to the contents of the job differing on different days. Peak exposures (>90°) were higher for ramp workers than for sorting area workers (trunk 0.6% ramp versus 0.3% sorting; right arm 1.3% ramp versus 0.7% sorting).

    CONCLUSIONS: Trunk and upper arm postures and movements among flight baggage handlers measured by inclinometry were similar to those found in other jobs comprising manual material handling, known to be associated with increased risks for musculoskeletal disorders. The results showed that full-shift trunk (FP) and, to some extent, peak arm exposures were higher for ramp workers compared with sorting workers.

  • 1796.
    Wahlström, Jens
    et al.
    Högskolan i Gävle, Akademin för hälsa och arbetsliv, Avdelningen för arbets- och folkhälsovetenskap, Arbetshälsovetenskap. Högskolan i Gävle, Centrum för belastningsskadeforskning. Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine, Umeå University, Umeå, Sweden.
    Bergsten, Eva
    Högskolan i Gävle, Akademin för hälsa och arbetsliv, Avdelningen för arbets- och folkhälsovetenskap, Arbetshälsovetenskap. Högskolan i Gävle, Centrum för belastningsskadeforskning.
    Trask, Catherine
    Högskolan i Gävle, Akademin för hälsa och arbetsliv, Avdelningen för arbets- och folkhälsovetenskap, Arbetshälsovetenskap. Högskolan i Gävle, Centrum för belastningsskadeforskning. Centre for Health and Safety in Agriculture, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada.
    Mathiassen, Svend Erik
    Högskolan i Gävle, Akademin för hälsa och arbetsliv, Avdelningen för arbets- och folkhälsovetenskap, Arbetshälsovetenskap. Högskolan i Gävle, Centrum för belastningsskadeforskning.
    Jackson, Jennie
    Högskolan i Gävle, Akademin för hälsa och arbetsliv, Avdelningen för arbets- och folkhälsovetenskap, Arbetshälsovetenskap. Högskolan i Gävle, Centrum för belastningsskadeforskning.
    Forsman, Mikael
    Högskolan i Gävle, Akademin för hälsa och arbetsliv, Avdelningen för arbets- och folkhälsovetenskap, Arbetshälsovetenskap. Högskolan i Gävle, Centrum för belastningsskadeforskning. IMM Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
    Full-shift trunk and upper arm postures and movements among aircraft baggage handlers2016Inngår i: Annals of Occupational Hygiene, ISSN 0003-4878, E-ISSN 1475-3162, Vol. 60, nr 8, s. 977-990Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objectives: The present study assessed full shift trunk and upper arm postural exposure amplitudes, frequencies, and durations among Swedish airport baggage handlers, and aimed to determine whether exposures differ between workers at the ramp (loading and unloading aircraft) and baggage sorting areas.

    Methods: Trunk and upper arm postures were measured using inclinometers during three full work shifts on each of 27, male baggage handlers working at a large Swedish airport. Sixteen of the baggage handlers worked on the ramp and 11 in the sorting area. Variables summarizing postures and movements were calculated, and mean values and variance components between subjects and within subject (between days) were estimated using restricted maximum likelihood algorithms in a one-way random effect model.

    Results: In total, data from 79 full shifts (651 hours) were collected with a mean recording time of 495 minutes per shift (range 319-632). On average, baggage handlers worked with the right and left arm elevated >60° for 6.4% and 6.3% of the total workday, respectively. The 90th percentile trunk forward projection (FP) was 34.1° and the 50th percentile trunk movement velocity was 8°s-1. For most trunk (FP) and upper arm exposure variables, between-subject variability was considerable, suggesting that the flight baggage handlers were not a homogeneously exposed group. A notable between-days variability pointed to the contents of the job differing on different days. Peak exposures (>90°) were higher for ramp workers than for sorting area workers (trunk 0.6% ramp vs 0.3% sorting; right arm 1.3% ramp vs 0.7% sorting).

    Conclusions: Trunk and upper arm postures and movements among flight baggage handlers measured by inclinometry were similar to those found in other jobs comprising manual material handling, known to be associated with increased risks for musculoskeletal disorders. The results showed that full-shift trunk (FP), and to some extent peak arm exposures, were higher for ramp workers compared to sorting workers.

  • 1797.
    Wahlström, Jens
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Yrkes- och miljömedicin.
    Burström, Lage
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Yrkes- och miljömedicin.
    Nilsson, Tohr
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Yrkes- och miljömedicin.
    Järvholm, Bengt
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Yrkes- och miljömedicin.
    Risk factors for hospitalization due to lumbar disc disease2012Inngår i: Spine, ISSN 0362-2436, E-ISSN 1528-1159, Vol. 37, nr 15, s. 1334-1339Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Study Design. Prospective cohort study

    Objective. To study biomechanical factors in relation to symptomatic lumbar disc disease

    Summary of Background Data. The importance of biomechanical factors in lumbar disc disease have been questioned the past decade and knowledge from large prospective studies is lacking.

    Methods. The study basis is a cohort of 263 529 Swedish construction workers who participated in a national occupational health surveillance programme from 1971 until 1992. The workers' job title, smoking habits, body weight, height and age were registered at the examinations. The occurrence of hospitalization due to lumbar disc disease from January 1 1987 until December 31 2003 was collected from a linkage with the Swedish Hospital Discharge Register.

    Results. There was an increased risk for hospitalization due to lumbar disc disease for several occupational groups compared to white-collar workers and foremen. Occupational groups with high biomechanical loads had the highest risks, e.g the relative risk for concrete workers was 1.55 (95% CI 1.29-1.87). A taller stature was consistently associated with an increased risk. The relative risk for a man of 190-199 cm height was 1.55 (95% CI 1.30-1.86) compared to a man being 170-179 cm. Body weight and smoking were also risk factors, but weaker than height. Workers in the age span of 30-39 had the highest relative risk (RR = 1.87; 95% CI 1.58-2.23) compared to those 20-29, while men 60-65 years old had a lower risk (RR = 0.86; 95%CI 0.68-1.09).

    Conclusions. This study indicates that factors increasing the load on the lumbar spine are associated with hospitalization for lumbar disc disease. Occupational biomechanical factors seem to be important, and a taller stature was consistently associated with an increased risk.

  • 1798.
    Wahlström, Jens
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Yrkes- och miljömedicin.
    Mathiassen, Svend Erik
    Liv, Per
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Yrkes- och miljömedicin.
    Hedlund, Pernilla
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Yrkes- och miljömedicin.
    Ahlgren, Christina
    Umeå universitet, Medicinska fakulteten, Institutionen för samhällsmedicin och rehabilitering, Sjukgymnastik.
    Forsman, Mikael
    Upper arm postures and movements in female hairdressers across four full working days2010Inngår i: Annals of Occupational Hygiene, ISSN 0003-4878, E-ISSN 1475-3162, Vol. 54, nr 5, s. 584-594Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    OBJECTIVES: To describe upper arm postures and movements among female hairdressers, including the variability between hairdressers, between days within hairdresser, and between tasks, as a basis for understanding the characteristics of exposures in the job, considering possible sources of variation and recovery, and discussing appropriate exposure assessment strategies.

    METHODS: Data on upper arm postures were collected using inclinometers during four working days the same week from 28 female hairdressers working in 13 salons. Twenty of the hairdressers noted customer on and off times in a diary, to allow separate analyses of customer tasks (CT) and auxiliary non-customer tasks (AT), including breaks. For a number of posture and movement variables, mean values and variance components between subjects (BS) and within subjects between days (BD) were estimated using restricted maximum likelihood algorithms in one-way random effect models.

    RESULTS: For the 20 hairdressers with diaries, CT accounted for 279 min (58%) (SD(BS) = 39 min and SD(BD) = 85 min) of the working day and AT and breaks for 207 min (42%) (SD(BS) = 46 min and SD(BD) = 88 min). The hairdressers worked with the right arm elevated >60 degrees for 6.8% of the whole job (SD(BS) = 2.8% and SD(BD) = 2.0%). On average, the hairdressers worked with the right arm elevated >60 degrees for 9.0% of the time during CT, compared to 3.7% during AT, resulting in a contrast between tasks of 0.35.

    CONCLUSIONS: Hairdressers may be at risk for developing musculoskeletal disorders in the neck and shoulders due to a considerable occurrence of highly elevated arms, especially during CT. On the other hand, we do not find reasons to classify hairdressing as a job with too little variation. Posture variability between days within hairdressers was in the same order of magnitude as that between hairdressers, suggesting that 'typical' workdays do not exist. The exposure contrast between CT and AT for variables describing elevated arm postures indicates that for these variables a simple task-based approach for estimating job exposure could be successful.

  • 1799.
    Wahlström, Jens
    et al.
    Högskolan i Gävle, Akademin för hälsa och arbetsliv, Avdelningen för arbets- och folkhälsovetenskap, CBF. Högskolan i Gävle, Centrum för belastningsskadeforskning.
    Mathiassen, Svend Erik
    Högskolan i Gävle, Akademin för hälsa och arbetsliv, Avdelningen för arbets- och folkhälsovetenskap, CBF. Högskolan i Gävle, Centrum för belastningsskadeforskning.
    Liv, Per
    Högskolan i Gävle, Akademin för hälsa och arbetsliv, Avdelningen för arbets- och folkhälsovetenskap, CBF. Högskolan i Gävle, Centrum för belastningsskadeforskning.
    Hedlund, Pernilla
    Department of Occupational and Environmental Medicine, Umea University Hospital, SE-901 85 Umeå, Sweden.
    Ahlgren, Christina
    Department of Community Medicine and Rehabilitation, Umea University, SE-901 87 Umeå, Sweden.
    Forsman, Mikael
    Department of Public Health Sciences, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
    Upper arm postures and movements in female hairdressers across four full working days2010Inngår i: Annals of Occupational Hygiene, ISSN 0003-4878, E-ISSN 1475-3162, Vol. 54, nr 5, s. 584-594Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    OBJECTIVES: To describe upper arm postures and movements among female hairdressers, including the variability between hairdressers, between days within hairdresser, and between tasks, as a basis for understanding the characteristics of exposures in the job, considering possible sources of variation and recovery, and discussing appropriate exposure assessment strategies. METHODS: Data on upper arm postures were collected using inclinometers during four working days the same week from 28 female hairdressers working in 13 salons. Twenty of the hairdressers noted customer on and off times in a diary, to allow separate analyses of customer tasks (CT) and auxiliary non-customer tasks (AT), including breaks. For a number of posture and movement variables, mean values and variance components between subjects (BS) and within subjects between days (BD) were estimated using restricted maximum likelihood algorithms in one-way random effect models. RESULTS: For the 20 hairdressers with diaries, CT accounted for 279 min (58%) (SD(BS) = 39 min and SD(BD) = 85 min) of the working day and AT and breaks for 207 min (42%) (SD(BS) = 46 min and SD(BD) = 88 min). The hairdressers worked with the right arm elevated >60 degrees for 6.8% of the whole job (SD(BS) = 2.8% and SD(BD) = 2.0%). On average, the hairdressers worked with the right arm elevated >60 degrees for 9.0% of the time during CT, compared to 3.7% during AT, resulting in a contrast between tasks of 0.35. CONCLUSIONS: Hairdressers may be at risk for developing musculoskeletal disorders in the neck and shoulders due to a considerable occurrence of highly elevated arms, especially during CT. On the other hand, we do not find reasons to classify hairdressing as a job with too little variation. Posture variability between days within hairdressers was in the same order of magnitude as that between hairdressers, suggesting that 'typical' workdays do not exist. The exposure contrast between CT and AT for variables describing elevated arm postures indicates that for these variables a simple task-based approach for estimating job exposure could be successful.

  • 1800.
    Wahlström, Jens
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Yrkes- och miljömedicin.
    Östman, Christina
    Leijon, Ola
    The effect of flooring on musculoskeletal symptoms in the lower extremities and low back among female nursing assistants2012Inngår i: Ergonomics, ISSN 0014-0139, E-ISSN 1366-5847, Vol. 55, nr 2, s. 248-255Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    This study examines the effect of changing the floor from a 2-mm homogenous vinyl floor to a 4-mm heterogeneous vinyl floor (1.5-mm wear layer and 2.5-mm foam layer) on musculoskeletal symptoms in the lower extremities and low back among nursing assistants in a geriatric care centre. A pre-post design with a reference group consisting of nursing assistants from a similar geriatric care centre was used. Follow-up measurements were carried out 12 and 24 months after the intervention by means of questionnaires. At the 1-year follow-up, the pain intensity score in the feet of the intervention group had decreased compared with the baseline value and remained statistically significant at the 2-year follow-up. The decrease in pain intensity score of the feet in the intervention group was statistically significantly different from the reference group, both after 1 and 2 years. Statement of Relevance: The results show the importance of flooring in the workplace with regard to reducing musculoskeletal symptoms. Appropriate flooring is especially important in the female-dominated health care sector, where workers must stand or walk for long periods.

33343536373839 1751 - 1800 of 1903
RefereraExporteraLink til resultatlisten
Permanent link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf