Change search
Refine search result
1234567 151 - 200 of 415
CiteExportLink to result list
Permanent link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Rows per page
  • 5
  • 10
  • 20
  • 50
  • 100
  • 250
Sort
  • Standard (Relevance)
  • Author A-Ö
  • Author Ö-A
  • Title A-Ö
  • Title Ö-A
  • Publication type A-Ö
  • Publication type Ö-A
  • Issued (Oldest first)
  • Issued (Newest first)
  • Created (Oldest first)
  • Created (Newest first)
  • Last updated (Oldest first)
  • Last updated (Newest first)
  • Disputation date (earliest first)
  • Disputation date (latest first)
  • Standard (Relevance)
  • Author A-Ö
  • Author Ö-A
  • Title A-Ö
  • Title Ö-A
  • Publication type A-Ö
  • Publication type Ö-A
  • Issued (Oldest first)
  • Issued (Newest first)
  • Created (Oldest first)
  • Created (Newest first)
  • Last updated (Oldest first)
  • Last updated (Newest first)
  • Disputation date (earliest first)
  • Disputation date (latest first)
Select
The maximal number of hits you can export is 250. When you want to export more records please use the Create feeds function.
  • 151.
    Idborg, Helena
    et al.
    Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden..
    Zandian, Arash
    SciLifeLab, Division of Affinity Proteomics, Department of Protein Science, KTH Royal Institute of Technology, Stockholm, Sweden..
    Ossipova, Elena
    Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden..
    Wigren, Edvard
    Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden..
    Preger, Charlotta
    Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden..
    Mobarrez, Fariborz
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cancer Pharmacology and Computational Medicine.
    Checa, Antonio
    Division of Physiological Chemistry 2, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden..
    Sohrabian, Azita
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology.
    Pucholt, Pascal
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Rheumatology.
    Sandling, Johanna K.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Rheumatology.
    Fernandes-Cerqueira, Cátia
    Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden..
    Rönnelid, Johan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology.
    Oke, Vilija
    Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden..
    Grosso, Giorgia
    Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden..
    Kvarnström, Marika
    Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden..
    Larsson, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry.
    Wheelock, Craig E
    Division of Physiological Chemistry 2, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden..
    Syvänen, Ann-Christine
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular Medicine. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Rönnblom, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Rheumatology.
    Kultima, Kim
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry.
    Persson, Helena
    Science for Life Laboratory, Drug Discovery and Development & School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, Stockholm, Sweden..
    Gräslund, Susanne
    Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden..
    Gunnarsson, Iva
    Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden..
    Nilsson, Peter
    SciLifeLab, Division of Affinity Proteomics, Department of Protein Science, KTH Royal Institute of Technology, Stockholm, Sweden..
    Svenungsson, Elisabet
    Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden..
    Jakobsson, Per-Johan
    Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden..
    Circulating Levels of Interferon Regulatory Factor-5 Associates With Subgroups of Systemic Lupus Erythematosus Patients.2019In: Frontiers in Immunology, ISSN 1664-3224, E-ISSN 1664-3224, Vol. 10, article id 1029Article in journal (Refereed)
    Abstract [en]

    Systemic Lupus Erythematosus (SLE) is a heterogeneous autoimmune disease, which currently lacks specific diagnostic biomarkers. The diversity within the patients obstructs clinical trials but may also reflect differences in underlying pathogenesis. Our objective was to obtain protein profiles to identify potential general biomarkers of SLE and to determine molecular subgroups within SLE for patient stratification. Plasma samples from a cross-sectional study of well-characterized SLE patients (n = 379) and matched population controls (n = 316) were analyzed by antibody suspension bead array targeting 281 proteins. To investigate the differences between SLE and controls, Mann-Whitney U-test with Bonferroni correction, generalized linear modeling and receiver operating characteristics (ROC) analysis were performed. K-means clustering was used to identify molecular SLE subgroups. We identified Interferon regulating factor 5 (IRF5), solute carrier family 22 member 2 (SLC22A2) and S100 calcium binding protein A12 (S100A12) as the three proteins with the largest fold change between SLE patients and controls (SLE/Control = 1.4, 1.4, and 1.2 respectively). The lowest p-values comparing SLE patients and controls were obtained for S100A12, Matrix metalloproteinase-1 (MMP1) and SLC22A2 (padjusted = 3 × 10-9, 3 × 10-6, and 5 × 10-6 respectively). In a set of 15 potential biomarkers differentiating SLE patients and controls, two of the proteins were transcription factors, i.e., IRF5 and SAM pointed domain containing ETS transcription factor (SPDEF). IRF5 was up-regulated while SPDEF was found to be down-regulated in SLE patients. Unsupervised clustering of all investigated proteins identified three molecular subgroups among SLE patients, characterized by (1) high levels of rheumatoid factor-IgM, (2) low IRF5, and (3) high IRF5. IRF5 expressing microparticles were analyzed by flow cytometry in a subset of patients to confirm the presence of IRF5 in plasma and detection of extracellular IRF5 was further confirmed by immunoprecipitation-mass spectrometry (IP-MS). Interestingly IRF5, a known genetic risk factor for SLE, was detected extracellularly and suggested by unsupervised clustering analysis to differentiate between SLE subgroups. Our results imply a set of circulating molecules as markers of possible pathogenic importance in SLE. We believe that these findings could be of relevance for understanding the pathogenesis and diversity of SLE, as well as for selection of patients in clinical trials.

  • 152.
    Iggman, David
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism.
    Rosqvist, Fredrik
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism.
    Larsson, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
    Ärnlöv, Johan
    Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology.
    Beckman, Lena
    Rudling, Mats
    Risérus, Ulf
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism.
    Role of Dietary Fats in Modulating Cardiometabolic Risk During Moderate Weight Gain: A Randomized Double-Blind Overfeeding Trial (LIPOGAIN Study)2014In: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, ISSN 2047-9980, E-ISSN 2047-9980, Vol. 3, no 5, article id e001095Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Whether the type of dietary fat could alter cardiometabolic responses to a hypercaloric diet is unknown. In addition, subclinical cardiometabolic consequences of moderate weight gain require further study.

    METHODS AND RESULTS: In a 7-week, double-blind, parallel-group, randomized controlled trial, 39 healthy, lean individuals (mean age of 27±4) consumed muffins (51% of energy [%E] from fat and 44%E refined carbohydrates) providing 750 kcal/day added to their habitual diets. All muffins had identical contents, except for type of fat; sunflower oil rich in polyunsaturated fatty acids (PUFA diet) or palm oil rich in saturated fatty acids (SFA diet). Despite comparable weight gain in the 2 groups, total: high-density lipoprotein (HDL) cholesterol, low-density lipoprotein:HDL cholesterol, and apolipoprotein B:AI ratios decreased during the PUFA versus the SFA diet (-0.37±0.59 versus +0.07±0.29, -0.31±0.49 versus +0.05±0.28, and -0.07±0.11 versus +0.01±0.07, P=0.003, P=0.007, and P=0.01 for between-group differences), whereas no significant differences were observed for other cardiometabolic risk markers. In the whole group (ie, independently of fat type), body weight increased (+2.2%, P<0.001) together with increased plasma proinsulin (+21%, P=0.007), insulin (+17%, P=0.003), proprotein convertase subtilisin/kexin type 9, (+9%, P=0.008) fibroblast growth factor-21 (+31%, P=0.04), endothelial markers vascular cell adhesion molecule-1, intercellular adhesion molecule-1, and E-selectin (+9, +5, and +10%, respectively, P<0.01 for all), whereas nonesterified fatty acids decreased (-28%, P=0.001).

    CONCLUSIONS: Excess energy from PUFA versus SFA reduces atherogenic lipoproteins. Modest weight gain in young individuals induces hyperproinsulinemia and increases biomarkers of endothelial dysfunction, effects that may be partly outweighed by the lipid-lowering effects of PUFA.

    CLINICAL TRIAL REGISTRATION URL: http://ClinicalTrials.gov. Unique identifier: NCT01427140.

  • 153.
    Inayat, S
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
    Larsson, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
    Ronquist, Gunnar K
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
    Ronquist, Göran
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
    Egberg, N
    Eliasson, R
    Carlsson, Lena
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
    High levels of cathepsins B, L and S in human seminal plasma and their association with prostasomes2012In: Andrologia, ISSN 0303-4569, E-ISSN 1439-0272, Vol. 44, no 6, p. 423-427Article in journal (Refereed)
    Abstract [en]

    Semen is a heterogenous and complex fluid with different functions, some of them well known, others still obscure. The aim of this study was to investigate the presence of cathepsins B, S and L in human seminal plasma and their possible associations with other semen variables. Cathepsin B, L and S concentrations were measured in seminal plasma from 99 men utilising commercial ELISA kits. Seminal plasma cathepsin B was approximately 70 times higher, while the cathepsin L values were approximately 500 times higher and the cathepsin S values approximately 40 times higher in seminal plasma than in a group of serum samples. The study shows that seminal plasma contains high levels of cathepsins B, L and S. All three cathepsins were also bound to the surface of prostasomes.

  • 154.
    Ingelsson, Erik
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
    Sundström, Johan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    Lind, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    Risérus, Ulf
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
    Larsson, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    Basu, Samar
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Ärnlöv, Johan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
    Low-grade albuminuria and the incidence of heart failure in a community-based cohort of elderly men2007In: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 28, no 14, p. 1739-1745Article in journal (Refereed)
    Abstract [en]

    Aims To investigate associations of urinary albumin excretion rate (UAER) and heart failure (HF) incidence in a community-based sample.

    Methods and results In a prospective study of 70-year-old men free from HF at baseline (n = 1106), UAER (from timed overnight samples) was analysed with established risk factors for HF [acute MI before baseline, acute MI during follow-up (modelled as a time-dependent covariate), hypertension, diabetes, left ventricular hypertrophy, smoking, body mass index, and glomerular filtration rate] and more recently described risk factors [high-sensitive C-reactive protein and insulin sensitivity (clamp glucose disposal rate)] as predictors of HF incidence.

    Ninety-eight participants developed HF during a median follow-up of 9.0 years. In Cox proportional hazards models adjusted for established and novel risk factors for HF, a 1 SD increase in log UAER increased the risk of HF in individuals without anti-hypertensive treatment (hazard ratio 1.49; 95% CI 1.13–1.98; P = 0.005). Furthermore, UAER remained an independent predictor of HF, also in participants without diabetes at baseline or myocardial infarction at baseline or during follow-up. There were no significant associations between UAER and HF incidence in individuals with anti-hypertensive treatment.

    Conclusion Our observations support the notion that low-grade albuminuria is a marker for subclinical cardiovascular damage that predisposes to future HF in the community.

  • 155. Inker, Lesley A
    et al.
    Grams, Morgan E
    Levey, Andrew S
    Coresh, Josef
    Cirillo, Massimo
    Collins, John F
    Gansevoort, Ron T
    Gutierrez, Orlando M
    Hamano, Takayuki
    Heine, Gunnar H
    Ishikawa, Shizukiyo
    Jee, Sun Ha
    Kronenberg, Florian
    Landray, Martin J
    Miura, Katsuyuki
    Nadkarni, Girish N
    Peralta, Carmen A
    Rothenbacher, Dietrich
    Schaeffner, Elke
    Sedaghat, Sanaz
    Shlipak, Michael G
    Zhang, Luxia
    van Zuilen, Arjan D
    Hallan, Stein I
    Kovesdy, Csaba P
    Woodward, Mark
    Lannfelt, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Larsson, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry.
    Ärnlöv, Johan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology.
    Levin, Adeera
    Relationship of Estimated GFR and Albuminuria to Concurrent Laboratory Abnormalities: An Individual Participant Data Meta-analysis in a Global Consortium2018In: American Journal of Kidney Diseases, ISSN 0272-6386, E-ISSN 1523-6838, Vol. 73, no 2, p. 206-217, article id S0272-6386(18)30916-8Article in journal (Refereed)
    Abstract [en]

    RATIONALE & OBJECTIVE: Chronic kidney disease (CKD) is complicated by abnormalities that reflect disruption in filtration, tubular, and endocrine functions of the kidney. Our aim was to explore the relationship of specific laboratory result abnormalities and hypertension with the estimated glomerular filtration rate (eGFR) and albuminuria CKD staging framework.

    STUDY DESIGN: Cross-sectional individual participant-level analyses in a global consortium.

    SETTING & STUDY POPULATIONS: 17 CKD and 38 general population and high-risk cohorts.

    SELECTION CRITERIA FOR STUDIES: Cohorts in the CKD Prognosis Consortium with data for eGFR and albuminuria, as well as a measurement of hemoglobin, bicarbonate, phosphorus, parathyroid hormone, potassium, or calcium, or hypertension.

    DATA EXTRACTION: Data were obtained and analyzed between July 2015 and January 2018.

    ANALYTICAL APPROACH: We modeled the association of eGFR and albuminuria with hemoglobin, bicarbonate, phosphorus, parathyroid hormone, potassium, and calcium values using linear regression and with hypertension and categorical definitions of each abnormality using logistic regression. Results were pooled using random-effects meta-analyses.

    RESULTS: The CKD cohorts (n=254,666 participants) were 27% women and 10% black, with a mean age of 69 (SD, 12) years. The general population/high-risk cohorts (n=1,758,334) were 50% women and 2% black, with a mean age of 50 (16) years. There was a strong graded association between lower eGFR and all laboratory result abnormalities (ORs ranging from 3.27 [95% CI, 2.68-3.97] to 8.91 [95% CI, 7.22-10.99] comparing eGFRs of 15 to 29 with eGFRs of 45 to 59mL/min/1.73m2), whereas albuminuria had equivocal or weak associations with abnormalities (ORs ranging from 0.77 [95% CI, 0.60-0.99] to 1.92 [95% CI, 1.65-2.24] comparing urinary albumin-creatinine ratio > 300 vs < 30mg/g).

    LIMITATIONS: Variations in study era, health care delivery system, typical diet, and laboratory assays.

    CONCLUSIONS: Lower eGFR was strongly associated with higher odds of multiple laboratory result abnormalities. Knowledge of risk associations might help guide management in the heterogeneous group of patients with CKD.

  • 156. James, Matthew T
    et al.
    Grams, Morgan E
    Woodward, Mark
    Elley, C Raina
    Green, Jamie A
    Wheeler, David C
    de Jong, Paul
    Gansevoort, Ron T
    Levey, Andrew S
    Warnock, David G
    Sarnak, Mark J
    A Meta-analysis of the Association of Estimated GFR, Albuminuria, Diabetes Mellitus, and Hypertension With Acute Kidney Injury.2015In: American Journal of Kidney Diseases, ISSN 0272-6386, E-ISSN 1523-6838, Vol. 66, no 4, p. 602-612Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Diabetes mellitus and hypertension are risk factors for acute kidney injury (AKI). Whether estimated glomerular filtration rate (eGFR) and urine albumin-creatinine ratio (ACR) remain risk factors for AKI in the presence and absence of these conditions is uncertain.

    STUDY DESIGN: Meta-analysis of cohort studies.

    SETTING & POPULATION: 8 general-population (1,285,045 participants) and 5 chronic kidney disease (CKD; 79,519 participants) cohorts.

    SELECTION CRITERIA FOR STUDIES: Cohorts participating in the CKD Prognosis Consortium.

    PREDICTORS: Diabetes and hypertension status, eGFR by the 2009 CKD Epidemiology Collaboration creatinine equation, urine ACR, and interactions.

    OUTCOME: Hospitalization with AKI, using Cox proportional hazards models to estimate HRs of AKI and random-effects meta-analysis to pool results.

    RESULTS: During a mean follow-up of 4 years, there were 16,480 episodes of AKI in the general-population and 2,087 episodes in the CKD cohorts. Low eGFRs and high ACRs were associated with higher risks of AKI in individuals with or without diabetes and with or without hypertension. When compared to a common reference of eGFR of 80mL/min/1.73m(2) in nondiabetic patients, HRs for AKI were generally higher in diabetic patients at any level of eGFR. The same was true for diabetic patients at all levels of ACR compared with nondiabetic patients. The risk gradient for AKI with lower eGFRs was greater in those without diabetes than with diabetes, but similar with higher ACRs in those without versus with diabetes. Those with hypertension had a higher risk of AKI at eGFRs>60mL/min/1.73m(2) than those without hypertension. However, risk gradients for AKI with both lower eGFRs and higher ACRs were greater for those without than with hypertension.

    LIMITATIONS: AKI identified by diagnostic code.

    CONCLUSIONS: Lower eGFRs and higher ACRs are associated with higher risks of AKI among individuals with or without either diabetes or hypertension.

  • 157. Jayasinghe, Saroj
    et al.
    Lind, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology.
    Salihovic, Samira
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology. Uppsala University, Science for Life Laboratory, SciLifeLab. MTM Research Centre, School of Science and Technology, Örebro University, Örebro, Sweden.
    Larsson, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry.
    Lind, P. Monica
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Occupational and Environmental Medicine.
    DDT and its metabolites could contribute to the aetiology of chronic kidney disease of unknown aetiology (CKDu) and more studies are a priority2019In: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 649, p. 1638-1639Article in journal (Refereed)
  • 158. Jayasinghe, Saroj
    et al.
    Lind, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology.
    Salihovic, Samira
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Larsson, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry.
    Lind, P. Monica
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Occupational and Environmental Medicine.
    High serum levels of p,p'-DDE are associated with an accelerated decline in GFR during 10 years follow-up.2018In: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 644, p. 371-374Article in journal (Refereed)
    Abstract [en]

    Over the past 20 years, the global incidence of chronic kidney disease (CKD) has been increasing and organochlorine pesticides (such as DDT) is a suspected etiological factor. The present study examines the associations between low level background exposure to p,p'-DDE (1-dichloro-2,2-bis (p-chlorophenyl) ethylene), the main DDT metabolite, and kidney function during a 10-year follow-up. Data was analysed from the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study (n = 1016, 50% women, all aged 70 years). Serum levels of p,p'-DDE was measured by gas chromatography coupled to high-resolution mass spectrometry (GC/HRMS) at baseline (i.e. age of 70 years). Glomerular filtration rate (GFR) was estimated using serum creatinine and cystatin C at 70, 75 and 80 years of age. A significant decline in GFR was seen during the 10-year follow-up (-24 ml/min/1.73 m2, p < 0.0001). A significant negative interaction was seen between baseline p,p'-DDE levels and change in GFR over time (p < 0.0001) following adjustment for sex, systolic blood pressure, diabetes, BMI, smoking and education level at age 70. Subjects with the lowest levels of p,p'-DDE levels at age 70 showed the lowest decline in GFR over 10 years, while subjects with the highest p,p'-DDE levels showed the greatest decline. Baseline levels of p,p'-DDE were related to an accelerated reduction in GFR over 10 years suggesting a nephrotoxic effect of DDT/p,p'-DDE. These findings support a potential role for DDT in the epidemic of CKD of unknown etiology (CKDu) in agricultural communities of Sri Lanka and Central America where DDT was previously used.

  • 159.
    Jernberg, Tomas
    et al.
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Medical Sciences.
    Lindahl, Bertil
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Medical Sciences.
    James, Stefan
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Medical Sciences.
    Larsson, Anders
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Medical Sciences. klinisk kemi.
    Hansson, Lars-Olof
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Medical Sciences. klinisk kemi.
    Wallentin, Lars
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Medical Sciences.
    Cystatin C: a novel predictor of outcome in suspected or confirmed non-ST-elevation acute coronary syndrome.2004In: Circulation, ISSN 1524-4539, Vol. 110, no 16, p. 2342-8Article in journal (Refereed)
  • 160.
    Jobs, Elisabeth
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
    Adamsson, Viola
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism.
    Larsson, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
    Jobs, Magnus
    Nerpin, Elisabet
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
    Ingelsson, Erik
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology.
    Ärnlöv, Johan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology.
    Risérus, Ulf
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism.
    Influence of a prudent diet on circulating cathepsin S in humans2014In: Nutrition Journal, ISSN 1475-2891, E-ISSN 1475-2891, Vol. 13, p. 84-Article in journal (Refereed)
    Abstract [en]

    Background: Increased circulating cathepsin S levels have been linked to increased risk of cardiometabolic diseases and cancer. However, whether cathepsin S is a modifiable risk factor is unclear. We aimed to investigate the effects of a prudent diet on plasma cathepsin S levels in healthy individuals. Findings: Explorative analyses of a randomized study were performed in 88 normal to slightly overweight and hyperlipidemic men and women (aged 25 to 65) that were randomly assigned to ad libitum prudent diet, i.e. healthy Nordic diet (ND) or a control group (habitual Western diet) for 6 weeks. Whereas all foods in the ND were provided, the control group was advised to consume their habitual diet throughout the study. The ND was in line with dietary recommendations, e. g. low in saturated fats, sugars and salt, but high in plant-based foods rich in fibre and unsaturated fats. The ND significantly decreased cathepsin S levels (from 20.1 (+/-4.0 SD) to 19.7 mu g/L (+/-4.3 SD)) compared with control group (from 18.2 (+/-2.9 SD) to 19.1 mu g/L (+/-3.8 SD)). This difference remained after adjusting for sex and change in insulin sensitivity (P = 0.03), and near significant after adjusting for baseline cathepsin S levels (P = 0.06), but not for change in weight or LDL-C. Changes in cathepsin S levels were directly correlated with change in LDL-C. Conclusions: Compared with a habitual control diet, a provided ad libitum healthy Nordic diet decreased cathepsin S levels in healthy individuals, possibly mediated by weight loss or lowered LDL-C. These differences between groups in cathepsin S were however not robust and therefore need further investigation.

  • 161.
    Jobs, Elisabeth
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
    Risérus, Ulf
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism.
    Ingelsson, Erik
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
    Helmersson, Johanna
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Oxidative Stress and Inflammation.
    Nerpin, Elisabet
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
    Jobs, M
    Sundström, Johan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    Lind, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    Larsson, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    Basu, Samar
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Oxidative Stress and Inflammation.
    Ärnlöv, Johan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
    Serum cathepsin S is associated with serum C-reactive protein and interleukin-6 independently of obesity in elderly men2010In: Journal of Clinical Endocrinology and Metabolism, ISSN 0021-972X, E-ISSN 1945-7197, Vol. 95, no 9, p. 4460-4464Article in journal (Refereed)
    Abstract [en]

    OBJECTIVE: Cathepsin S has been suggested provide a mechanistic link between obesity and atherosclerosis, possibly mediated via adipose tissue-derived inflammation. Previous data have shown an association between circulating cathepsin S and inflammatory markers in the obese, but to date, community-based reports are lacking. Accordingly, we aimed to investigate the association between serum levels of cathepsin S and markers of cytokine-mediated inflammation in a community-based sample, with prespecified subgroup analyses in nonobese participants. METHODS: Serum cathepsin S, C-reactive protein (CRP), and IL-6 were measured in a community-based cohort of elderly men (Uppsala Longitudinal Study of Adult Men; mean age 71 years, n = 991). CRP and IL-6 were also measured at a reexamination after 7 yr. RESULTS: After adjustment for age, body mass index, fasting plasma glucose, diabetes treatment, systolic blood pressure, diastolic blood pressure, hypertension treatment, serum cholesterol, serum high-density lipoprotein cholesterol, prior cardiovascular disease, smoking, and leisure time physical activity, higher cathepsin S was associated with higher CRP (regression coefficient for 1 sd increase, 0.13; 95% confidence interval 0.07-0.19; P < 0.001) and higher serum IL-6 (regression coefficient for 1 sd increase, 0.08; 95% confidence interval 0.01-0.14; P = 0.02). These associations remained similar in normal-weight participants (body mass index <25 kg/m(2), n = 375). In longitudinal analyses, higher cathepsin S at baseline was associated with higher serum CRP and IL-6 after 7 yr. CONCLUSIONS: These results provide additional evidence for the interplay between cathepsin S and inflammatory activity and suggest that this association is present also in normal-weight individuals in the community.

  • 162.
    Jobs, Elisabeth
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
    Risérus, Ulf
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism.
    Ingelsson, Erik
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
    Sundström, Johan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    Jobs, Magnus
    University of Dalarna.
    Nerpin, Elisabet
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
    Iggman, David
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism.
    Basu, Samar
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Oxidative Stress and Inflammation.
    Larsson, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
    Lars, Lind
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology.
    Ärnlöv, Johan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
    Serum cathepsin S is associated with decreased insulin sensitivity and the development of diabetes type 2 in a community-based cohort of elderly men2013In: Diabetes Care, ISSN 0149-5992, E-ISSN 1935-5548, Vol. 36, no 1, p. 163-165Article in journal (Refereed)
    Abstract [en]

    OBJECTIVE:

    To investigate associations between serum cathepsin S, impaired insulin sensitivity, defective insulin secretion, and diabetes risk in a community-based sample of elderly men without diabetes.

    RESEARCH DESIGN AND METHODS:

    Serum cathepsin S, insulin sensitivity (euglycemic-hyperinsulinemic clamp), and insulin secretion (early insulin response during an oral glucose tolerance test) were measured in 905 participants of the Uppsala Longitudinal Study of Adult Men (mean age, 71 years). Thirty participants developed diabetes during 6 years of follow-up.

    RESULTS:

    After adjustment for age, anthropometric variables, and inflammatory markers, higher cathepsin S was associated with decreased insulin sensitivity (regression coefficient per SD increase -0.09 [95% CI -0.14 to -0.04], P = 0.001), but no association with early insulin response was found. Moreover, higher cathepsin S was associated with a higher risk for developing diabetes (odds ratio per SD increase 1.48 [1.08-2.01], P = 0.01).

    CONCLUSIONS:

    Cathepsin S activity appears to be involved in the early dysregulation of glucose and insulin metabolism.

  • 163. Johansson, Niclas
    et al.
    Kalin, Mats
    Backman-Johansson, Carolina
    Larsson, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
    Nilsson, Kristina
    Hedlund, Jonas
    Procalcitonin levels in community-acquired pneumonia: correlation with aetiology and severity2014In: Scandinavian Journal of Infectious Diseases, ISSN 0036-5548, E-ISSN 1651-1980, Vol. 46, no 11, p. 787-791Article in journal (Refereed)
    Abstract [en]

    We studied procalcitonin (PCT) levels at hospital admittance and their association with aetiology and severity in patients with community-acquired pneumonia (CAP). Median PCT concentrations were higher in bacteraemic patients than in those without bacteraemia (6.11 μg/L vs 0.34 μg/L, p = 0.0002), in patients with non-bacteraemic pneumococcal aetiology than in those infected with other classic bacteria (1.18 vs 0.18, p = 0.038), and in patients with pneumococcal as compared with viral aetiology (2.43 vs 0.24, p = 0.017). When aetiology, bacteraemia and severity according to the pneumonia severity index (PSI) were included in logistic regression analyses with PCT > 0.5 as a dependent variable, the odds ratio (OR) for non-bacteraemic pneumococcal aetiology was 5.7 (p = 0.008) and 3.0 ( p = 0.1) for PSI 4-5. A separate analysis for bacteraemia and PSI 4-5 showed an OR of 17.5 (p = 0.008) and 2.7 (p = 0.092), respectively. In CAP patients, high PCT seems to be a good marker for invasive disease and pneumococcal aetiology. As a predictor of severity it appears to be less important.

  • 164.
    Johnston, Nina
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    Jernberg, Tomas
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
    Lindahl, Bertil
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
    Lindbäck, Johan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
    Stridsberg, Mats
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemical endocrinology.
    Larsson, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry.
    Venge, Per
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry.
    Wallentin, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
    Biochemical indicators of cardiac and renal function in a healthy elderly population2004In: Clinical Biochemistry, ISSN 0009-9120, E-ISSN 1873-2933, Vol. 37, no 3, p. 210-216Article in journal (Refereed)
    Abstract [en]

    Objectives:

    To examine the distributions of NT-proBNP and cystatin C and their relation to age, gender, and other physiological factors in an apparently healthy elderly population.

    Method:

    NT-proBNP and cystatin C were analyzed in 407 and 408 healthy individuals, median age: 65 (range 40–76).

    Results:

    Increasing age, female gender and CRP were independently associated to higher NT-proBNP levels. Age, body mass index, and CRP level were independently associated to the cystatin C level. In women and men, ≤65 years, the 97.5th percentile value for NT-proBNP was 268 ng/l and 184 ng/l, in those older, 391 ng/l and 269 ng/l. For those ≤65 years the 97.5th percentile value for cystatin C was 1.12 mg/l, and for those older 1.21 mg/l.

    Conclusion:

    In a healthy elderly population, NT-proBNP is influenced by age and gender, whereas cystatin C is influenced by age but not by gender. Both markers seem to be associated to the CRP level.

  • 165.
    Jonsson, Anna-Karin
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Infectious Diseases.
    Larsson, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
    Tängdén, Thomas
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Infectious Diseases.
    Melhus, Åsa
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
    Lannergård, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Microbiology and Infectious Medicine. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Infectious Diseases.
    A trial with IgY chicken antibodies to eradicate faecal carriage of Klebsiella pneumoniae and Escherichia coli producing extended-spectrum beta-lactamases2015In: Infection Ecology & Epidemiology, ISSN 2000-8686, E-ISSN 2000-8686, Vol. 5, article id 28224Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae is an emerging therapeutic challenge, especially in the treatment of urinary tract infections. Following an outbreak of CTX-M-15 Klebsiella pneumoniae in Uppsala, Sweden, an orphan drug trial on IgY chicken antibodies was undertaken in an attempt to eradicate faecal carriage of ESBL-producing K. pneumoniae and Escherichia coli.

    METHODS: Hens were immunised with epitopes from freeze-dried, whole-cell bacteria (ESBL-producing K. pneumoniae and E. coli) and recombinant proteins of two K. pneumoniae fimbriae subunits (fimH and mrkD). The egg yolks were processed according to good manufacturing practice and the product was stored at-20°C until used. Using an internal database from the outbreak and the regular laboratory database, faecal carriers were identified and recruited from May 2005 to December 2013. The participants were randomised in a placebo-controlled 1:1 manner.

    RESULTS: From 749 eligible patients, 327 (44%) had deceased, and only 91 (12%) were recruited and signed the informed consent. In the initial screening performed using the polymerase chain reaction, 24 participants were ESBL positive and subsequently randomised and treated with either the study drug or a placebo. The study was powered for 124 participants. Because of a very high dropout rate, the study was prematurely terminated. From the outbreak cohort (n=247), only eight patients were screened, and only one was positive with the outbreak strain in faeces.

    CONCLUSIONS: The present study design, using IgY chicken antibodies for the eradication of ESBL-producing K. pneumonia and E. coli, was ineffective in reaching its goal due to high mortality and other factors resulting in a low inclusion rate. Spontaneous eradication of ESBL-producing bacteria was frequently observed in recruited participants, which is consistent with previous reports.

  • 166. Jonsson, A-S.
    et al.
    Flodin, Mats
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    Hansson, L-O.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    Larsson, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry.
    Estimated glomerular filtration rate (eGFRCystC) from serum cystatin C shows strong agreement with iohexol clearance in patients with low GFR2007In: Scandinavian Journal of Clinical and Laboratory Investigation, ISSN 0036-5513, E-ISSN 1502-7686, Vol. 67, no 8, p. 801-809Article in journal (Refereed)
    Abstract [en]

    OBJECTIVE: Estimation of glomerular filtration rate (eGFR) is essential in the diagnosis and monitoring of patients with kidney disease and for correct dosage of drugs eliminated from the circulation by the kidneys. Cystatin C has been shown in several studies to be superior to creatinine in estimating eGFR. However, there are few studies on the performance of cystatin C estimated eGFR (eGFRCystC) in patients with advanced kidney disease and low GFR. MATERIAL AND METHODS: We measured serum cystatin C, together with serum creatinine, during iohexol clearance in patients with iohexol clearance below 30 mL/min/1.73 m2. The cystatin C values were used to calculate eGFRCystC using the formula eGFR (mL/min/1.73 m2) = 79.901*(cystatin C value in mg/L)-1.4389. RESULTS: There was good correlation between eGFRCystC and iohexol clearance (r = 0.88) in patients with iohexol clearance.

  • 167. Jonsson, M
    et al.
    Hansson, L-O
    Larsson, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry.
    Grubb, Anders
    Plasmaproteiner, inflammation och amyloidos2018In: Laurells klinisk kemi i praktisk medicin. / [ed] Theodorsson E. ; Berggren Söderlund, M., Lund: Studentlitteratur AB, 2018, 10, p. 87-130Chapter in book (Refereed)
  • 168.
    Jonsson, Niklas
    et al.
    Section of Anaesthesia and Intensive Care Medicine, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
    Nilsen, Tom
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry.
    Gille-Johnson, Patrik
    Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden..
    Bell, Max
    Section of Anaesthesia and Intensive Care Medicine, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden..
    Martling, Claes-Roland
    Section of Anaesthesia and Intensive Care Medicine, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden..
    Larsson, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry.
    Mårtensson, Johan
    Section of Anaesthesia and Intensive Care Medicine, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden..
    Calprotectin as an early biomarker of bacterial infections in critically ill patients: an exploratory cohort assessment2017In: Criminology & Public Policy, ISSN 1441-2772, E-ISSN 1941-1006, Vol. 19, no 3, p. 205-213Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Calprotectin is the most abundant protein in the cytosolic fraction of neutrophils, and neutrophil degranulation is a major response to bacterial infections.

    OBJECTIVES: To assess the value of plasma calprotectin as an early marker of bacterial infections in critically ill patients and compare it with the corresponding values for procalcitonin (PCT), C-reactive protein (CRP) and white blood cell count (WBC).

    METHODS: We measured daily plasma calprotectin levels in 110 intensive care unit patients using a newly developed turbidimetric assay run on clinical chemistry analysers. The likelihood of infection was determined according to the International Sepsis Forum criteria.

    RESULTS: Overall, 58 patients (52.7%) developed a suspected or confirmed bacterial infection. Plasma calprotectin predicted such infections within 24 hours with an area under the receiver operating characteristics curve (ROC area) of 0.78 (95% CI, 0.68-0.89). The ROC area for calprotectin was significantly greater than the corresponding ROC areas for WBC (P < 0.001) and PCT (P = 0.02) but only marginally better than the ROC area for CRP (0.71; 95% CI, 0.68-0.89).

    CONCLUSION: Plasma calprotectin appears to be a useful early marker of bacterial infections in critically ill patients, with better predictive characteristics than WBC and PCT.

  • 169.
    Junus, Katja
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.
    Majali-Martinez, Alejandro
    Department of Obstetrics and Gynecology, Medical University of Graz, Austria.
    Kallak, Theodora Kunovac
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.
    Larsson, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry.
    Olovsson, Matts
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Reproductive biology.
    Primary Term Trophoblasts Release NT-proBNPManuscript (preprint) (Other academic)
  • 170.
    Junus, Katja
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.
    Wikström, Anna-Karin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden.
    Larsson, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
    Olovsson, Matts
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.
    Early second-trimester plasma levels of NT-proBNP in women who subsequently develop early-onset preeclampsia2017In: The Journal of Maternal-Fetal & Neonatal Medicine, ISSN 1476-7058, E-ISSN 1476-4954, Vol. 30, no 18, p. 2163-2165Article in journal (Refereed)
    Abstract [en]

    Plasma levels of NT-proBNP are elevated in women with preeclampsia at the time of diagnosis. The objective of this case-control study was to evaluate N-terminal proBNP (NT-proBNP) in maternal plasma as an early second-trimester biomarker for prediction of early-onset preeclampsia. In early second-trimester samples, women who later developed preeclampsia at gestational age 34 wk + 0 or earlier (n = 16) had similar plasma levels of NT-proBNP (median 51.8, range 26.1-131.9 pg/ml) as women with uncomplicated pregnancy outcomes (n = 43) (53.0, 14.9-184.2 pg/ml). The early second-trimester level of NT-proBNP cannot therefore be used as a predictive biomarker of early-onset preeclampsia.

  • 171.
    Junus, Katja
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Obstetrics and Gynaecology.
    Wikström, Anna-Karin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Obstetrics and Gynaecology.
    Larsson, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
    Olovsson, Matts
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Obstetrics and Gynaecology.
    Placental Expression of proBNP/NT-proBNP and Plasma Levels of NT-proBNP in Early- and Late-Onset Preeclampsia2014In: American Journal of Hypertension, ISSN 0895-7061, E-ISSN 1941-7225, Vol. 27, no 9, p. 1225-1230Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Levels of plasma N-terminal pro B-type natriuretic peptide (NT-proBNP) are elevated in preeclampsia. In this study, the possibility that the placenta produces and releases proBNP/NT-proBNP was explored. Plasma levels of NT-proBNP in early- and late-onset preeclampsia were also measured.

    METHODS: Placental proBNP mRNA in early-onset preeclampsia (n = 7), late-onset preeclampsia (n = 8), and controls of similar gestational age (n = 10) was assessed by quantitative real-time polymerase chain reaction. ProBNP/NT-proBNP protein was studied in placental samples with immunohistochemistry (n = 8) and tissue culture (n = 2). Plasma levels of NT-proBNP were measured in early-onset preeclampsia (n = 18), late-onset preeclampsia (n = 20), and relevant controls (n = 36).

    RESULTS: Transcripts of proBNP mRNA were found in 20 out of 25 samples, there were no differences in expression between the groups. ProBNP/NT-proBNP protein was observed in maternal spiral arteries and in syncytiotrophoblasts in all placental samples. After placental tissue culture, there were measurable amounts of NT-proBNP in the culture media. Women with both early- (365 [14-9815] pg/ml) and late-onset preeclampsia (176 [33-2547] pg/ml) had higher levels of NT-proBNP than their controls (P < 0.001). There was a tendency toward higher levels of NT-proBNP in women with early-onset preeclampsia than in women with late-onset preeclampsia (P = 0.057).

    CONCLUSION: The results indicate possible placental production and release of proBNP/NT-proBNP into the maternal circulation.

  • 172.
    Karawajczyk, Malgorzata
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
    Haile, Saba
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
    Grabski, Magnus
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Pediatrics.
    Larsson, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
    The HemoCue WBC DIFF system could be used for leucocyte and neutrophil counts but not for full differential counts2017In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 106, no 6, p. 974-978Article in journal (Refereed)
    Abstract [en]

    AIM: The aim of this study was to evaluate the HemoCue WBC DIFF system for point of care testing of fingerstick samples from paediatric patients.

    METHODS: We analysed 158 white blood cell counts on both the point of care HemoCue WBC DIFF instrument and the Cell Dyn Sapphire cell counter used by our central laboratory and compared the results. The measurements were performed using fingerstick samples drawn by nurses working in paediatric emergency and paediatric oncology units.

    RESULTS: There was good agreement between the two instruments for white blood cell and neutrophil counts. The correlation was weaker for lymphocytes and the correlations were poor for monocytes and eosinophils. The HemoCue WBC DIFF flagged 56 of the 148 capillary drawn samples as abnormal, but none of the 10 venously collected samples. Only two of the flagged samples differed significantly between the instruments, with regard to the cell counts.

    CONCLUSION: The correlations between the white blood cell counts and neutrophil counts in this real life study were good enough to diagnose children in emergency department and oncology unit settings. However, the high number of pathological flags from fingerstick samples, which made reruns necessary, limited the usefulness of the instrument.

  • 173.
    Karawajczyk, Malgorzata
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry.
    Larsson, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry.
    Point-of-care instruments need to offer high levels of accuracy2017In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 106, no 10, article id 1707Article in journal (Other academic)
  • 174.
    Karawajczyk, Malgorzata
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    Ramklint, Mia
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Psychiatry, University Hospital.
    Larsson, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    Reduced cystatin C-estimated GFR and increased creatinine-estimated GFR in comparison with iohexol-estimated GFR in a hyperthyroid patient: A case report2008In: Journal of Medical Case Reports, ISSN 1752-1947, Vol. 2, no 66Article in journal (Other academic)
    Abstract [en]

    ABSTRACT: INTRODUCTION: Estimation of the glomerular filtration rate (GFR) is essential for the evaluation of patients with kidney disease, and for treating patients with drugs that are eliminated from the circulation by the kidneys. Cystatin C has been shown to be superior to creatinine for estimating GFR in several studies. However, studies showing that thyroid function has an impact on cystatin C have not addressed the question of whether the changes in cystatin C levels are due to changes in GFR or in cystatin C synthesis. CASE PRESENTATION: We report an account of a hyperthyroid patient with a discrepancy between the GFR estimates from cystatin C and creatinine. The cystatin C concentration (1.36 mg/L) was higher and gave an estimated GFR which was lower (51 mL/min/1.73 m2), while the creatinine concentration was lower (36 mumol/L) and gave a corresponding creatinine-estimated GFR that was higher (145 mL/min/1.73 m2) than the iohexol-estimated GFR (121 mL/min/1.73 m2) during the hyperthyroid period. After thyroidectomy, the creatinine concentration was 36 mumol/L and creatinine-estimated GFR was calculated as 73 mL/min/1.73 m2, while the cystatin C concentration and cystatin C-calculated GFR was 0.78 mg/L and 114 mL/min/1.73 m2, respectively. CONCLUSION: In contrast to creatinine, cystatin C levels rose in the hyperthyroid state as compared to the euthyroid state. The cystatin C-estimated GFR was reduced compared to the iohexol-estimated GFR. This patient case shows that the hyperthyroid-associated changes in cystatin C levels are not due to changes in GFR. Thyroid function should thus be considered when both cystatin C and creatinine are used as markers of kidney function.

  • 175.
    Karlsson, J
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
    Helmersson-Karlqvist, Johanna
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
    Larsson, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
    Delayed mixing of vacuum tubes clearly affects platelet counts but not haemoglobin concentration and prothrombin time (INR) results2013In: International Journal of Laboratory Hematology, ISSN 1751-5521, E-ISSN 1751-553X, Vol. 35, no 6, p. E15-E17Article in journal (Other academic)
  • 176.
    Karlsson, Marie
    et al.
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Medical Sciences. klinisk kemi.
    Kollberg, Hans
    Department of Women's and Children's Health.
    Larsson, Anders
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Medical Sciences. klinisk kemi.
    Chicken IgY. Utilizing the evolutionary advantage.2004In: World Poultry Science, Vol. 50, no 3, p. 341-348Article in journal (Refereed)
  • 177. Kassebaum, Nicholas J
    The Global Burden of Anemia2016In: Hematology/Oncology Clinics of North America, ISSN 0889-8588, E-ISSN 1558-1977, Vol. 30, no 2, p. 247-308Article in journal (Refereed)
    Abstract [en]

    Anemia is an important cause of health loss. We estimated levels and trends of nonfatal anemia burden for 23 distinct etiologies in 188 countries, 20 age groups, and both sexes from 1990 to 2013. All available population-level anemia data were collected and standardized. We estimated mean hemoglobin, prevalence of anemia by severity, quantitative disability owing to anemia, and underlying etiology for each population using the approach of the Global Burden of Disease, Injuries and Risk Factors 2013 Study. Anemia burden is high. Developing countries account for 89% of all anemia-related disability. Iron-deficiency anemia remains the dominant cause of anemia.

  • 178.
    Kassebaum, Nicholas J.
    et al.
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Arora, Megha
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Barber, Ryan M.
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Bhutta, Zulfigar A.
    Ctr Excellence Women & Child Hlth, Karachi, Pakistan.;Ctr Global Child Hlth, Toronto, ON, Canada..
    Carter, Austin
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Casey, Daniel C.
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Charlson, Fiona J.
    Inst Hlth Metr & Evaluat, Seattle, WA USA.;Univ Queensland, Sch Publ Hlth, Brisbane, Qld, Australia.;Queensland Ctr Mental Hlth Res, Brisbane, Qld, Australia..
    Coates, Matthew M.
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Coggeshall, Megan
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Cornaby, Leslie
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Dandona, Lalit
    Inst Hlth Metr & Evaluat, Seattle, WA USA.;Publ Hlth Fdn India, New Delhi, India..
    Dicker, Daniel J.
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Erskine, Holly E.
    Inst Hlth Metr & Evaluat, Seattle, WA USA.;Univ Queensland, Sch Publ Hlth, Brisbane, Qld, Australia.;Queensland Ctr Mental Hlth Res, Brisbane, Qld, Australia..
    Ferrari, Alize J.
    Inst Hlth Metr & Evaluat, Seattle, WA USA.;Univ Queensland, Sch Publ Hlth, Brisbane, Qld, Australia.;Queensland Ctr Mental Hlth Res, Brisbane, Qld, Australia..
    Fitzmaurice, Christina
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Foreman, Kyle
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Forouzanfar, Mohammad H.
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Fullman, Nancy
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Gething, Peter W.
    Univ Oxford, Dept Zool, Oxford, England..
    Goldberg, Ellen M.
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Graetz, Nicholas
    Haagsma, Juanita A.
    Inst Hlth Metr & Evaluat, Seattle, WA USA.;Univ Med Ctr, Dept Publ Hlth, Erasmus MC, Rotterdam, Netherlands..
    Johnson, Catherine
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Kemmer, Laura
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Khalil, Ibrahim A.
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Kinfu, Yohannes
    Inst Hlth Metr & Evaluat, Seattle, WA USA.;Univ Canberra, Fac Hlth, Ctr Res Action Publ Hlth, Canberra, ACT, Australia..
    Kutz, Michael J.
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Kyu, Hmwe H.
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Leung, Janni
    Inst Hlth Metr & Evaluat, Seattle, WA USA.;Univ Queensland, Sch Publ Hlth, Brisbane, Qld, Australia.;Queensland Ctr Mental Hlth Res, Brisbane, Qld, Australia..
    Liang, Xiaofeng
    Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China..
    Lim, Stephen S.
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Lozano, Rafael
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Mensah, George A.
    NHLBI, NIH, Ctr Translat Res & Implementat Sci, Bldg 10, Bethesda, MD 20892 USA..
    Mikesell, Joe
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Mokdad, Ali H.
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Mooney, Meghan D.
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Naghavi, Mohsen
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Nguyen, Grant
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Nsoesie, Elaine
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Pigott, David M.
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Pinho, Christine
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Rankin, Zane
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Reinig, Nikolas
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Salomon, Joshua A.
    Inst Hlth Metr & Evaluat, Seattle, WA USA.;Harvard Univ, Dept Global Hlth & Populat, Boston, MA 02115 USA..
    Sandar, Logan
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Smith, Alison
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Sorensen, Reed J. D.
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Stanaway, Jeffrey
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Steiner, Caitlyn
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Teeple, Stephanie
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Thomas, Bernadette A.
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Troeger, Chris
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    VanderZanden, Amelia
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Wagner, Joseph A.
    Inst Hlth Metr & Evaluat, Seattle, WA USA.;Natl Inst Occupat Safety & Hlth, Washington, DC USA..
    Wanga, Valentine
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Whiteford, Harvey A.
    Inst Hlth Metr & Evaluat, Seattle, WA USA.;Univ Queensland, Sch Publ Hlth, Brisbane, Qld, Australia.;Queensland Ctr Mental Hlth Res, Brisbane, Qld, Australia..
    Zhou, Maigeng
    Inst Hlth Metr & Evaluat, Seattle, WA USA.;Natl Ctr Chron & Noncommunicable Dis Control & Pr, Beijing, Peoples R China..
    Zoeckler, Leo
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Abajobir, Amanuel Alemu
    Univ Queensland, Sch Publ Hlth, Brisbane, Qld, Australia..
    Abate, Kalkidan Hassen
    Jimma Univ, Jimma, Ethiopia..
    Abbafati, Cristiana
    Univ Roma La Sapienza, Rome, Italy..
    Abbas, Kaja M.
    Virginia Tech, Blacksburg, VA USA..
    Abd-Allah, Foad
    Cairo Univ, Dept Neurol, Cairo, Egypt..
    Abraham, Biju
    NM SM Govt Coll, Kalpetta, Kerala, India..
    Abubakar, Ibrahim
    Inst Global Hlth, London, England..
    Abu-Raddad, Laith J.
    Weill Cornell Med Coll Qatar, Infect Dis Epidemiol Grp, Doha, Qatar.;Birzeit Univ, Inst Community & Publ Hlth, Ramallah, Israel..
    Abu-Rmeileh, Niveen M. E.
    Birzeit Univ, Inst Community & Publ Hlth, Ramallah, Israel..
    Achoki, Tom
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Ackerman, Ilana N.
    Monash Univ, Dept Epidemiol & Prevent Med, Sch Publ Hlth & Prevent Med, Melbourne, Vic, Australia..
    Adebiyi, Akindele Olupelumi
    Univ Ibadan, Coll Med, Ibadan, Nigeria.;Univ Coll Hosp, Ibadan, Nigeria..
    Adedeji, Isaac Akinkunmi
    Olabisi Onabanjo Univ, Ago Iwoye, Nigeria..
    Adsuar, Jose C.
    Univ Extremadura, Caceres, Spain..
    Afanvi, Kossivi Agbelenko
    Direct Dist Sanitaire Haho, Notse, Togo.;Univ Lome, Fac Sci Sante, Lome, Togo..
    Afshin, Ashkan
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Agardh, Emilie Elisabet
    Inst Publ Hlth Sci, Stockholm, Sweden..
    Agarwal, Arnav
    Univ Toronto, Toronto, ON, Canada.;McMaster Univ, Hamilton, ON, Canada..
    Kumar, Sanjay
    Ahmed, Muktar Beshir
    Jimma Univ, Jimma, Ethiopia..
    Kiadaliri, Aliasghar Ahmad
    Lund Univ, Dept Clin Sci Lund, Orthoped, Clin Epidemiol Unit, Lund, Sweden.;Kerman Univ Med Sci, Inst Futures Studies Hlth, Hlth Serv Management Res Ctr, Kerman, Iran..
    Ahmadieh, Hamid
    Shahid Beheshti Univ Med Sci, Ophthalm Res Ctr, Tehran, Iran.;Labbafinejad Med Ctr, Dept Ophthalmol, Tehran, Iran..
    Akseer, Nadia
    Ctr Global Child Hlth, Toronto, ON, Canada.;Dalla Lana Sch Publ Hlth, Toronto, ON, Canada..
    Al-Aly, Ziyad
    Washington Univ, St Louis, MO USA..
    Alam, Khurshid
    Murdoch Childrens Res Inst, Melbourne, Vic, Australia.;Univ Melbourne, Melbourne, Vic, Australia.;Univ Sydney, Sydney, NSW, Australia..
    Alam, Noore K. M.
    Univ Queensland, Brisbane, Qld, Australia.;Queensland Hlth, Herston, Qld, Australia..
    Aldhahri, Saleh Fahed
    King Saud Univ, Riyadh, Saudi Arabia.;King Fahad Med City, Riyadh, Saudi Arabia..
    Alegretti, Miguel Angel
    Fac Med, Dept Prevent & Social Med, Montevideo, Uruguay..
    Aleman, Alicia V.
    Sch Med, Montevideo, Uruguay..
    Alemu, Zewdie Aderaw
    Debre Markos Univ, Debre Markos, Ethiopia..
    Alexander, Lily T.
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Raghib, Ali
    Univ Oxford, Oxford, England..
    Alkerwi, Ala'a
    LIH, Strassen, Luxembourg..
    Alla, Francois
    Univ Lorraine, Sch Publ Hlth, Nancy, France..
    Allebeck, Peter
    Karolinska Inst, Dept Publ Hlth Sci, Stockholm, Sweden..
    Alsharif, Ubai
    Charite, Berlin, Germany..
    Altirkawi, Khalid A.
    King Saud Univ, Riyadh, Saudi Arabia..
    Martin, Elena Alvarez
    Minist Hlth Social Policy & Equal, Spanish Observ Drugs, Govt Delegat Natl Plan Drugs, Madrid, Spain..
    Alvis-Guzman, Nelson
    Univ Cartagena, Cartagena Indias, Colombia..
    Amare, Azmeraw T.
    Univ Adelaide, Sch Med, Adelaide, SA, Australia.;Bahir Dar Univ, Coll Med & Hlth Sci, Bahir Dar, Ethiopia..
    Amberbir, Alemayehu
    Dignitas Int, Zomba, Malawi..
    Amegah, Adeladza Kofi
    Univ Cape Coast, Cape Coast, Ghana.;Natl Hosp, Abuja, Nigeria..
    Amini, Heresh
    Kurdistan Univ Med Sci, Environm Hlth Res Ctr, Sanandaj, Iran.;Swiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, Basel, Switzerland.;Univ Basel, Basel, Switzerland..
    Ammar, Walid
    Minist Publ Hlth, Beirut, Lebanon..
    Amrock, Stephen Marc
    Oregon Hlth & Sci Univ, Portland, OR 97201 USA..
    Anderson, Gregory M.
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Anderson, Benjamin O.
    Univ Washington, Seattle, WA 98195 USA..
    Antonio, Carl Abelardo T.
    Univ Philippines, Dept Hlth Policy & Adm, Coll Publ Hlth, Manila, Philippines. Uppsala Univ, Dept Med Sci, Uppsala, Sweden..
    Anwari, Palwasha
    Self Employed, Kabul, Afghanistan..
    Ärnlöv, Johan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology. Dalarna Univ, Falun, Sweden..
    Arsenijevic, Valentina S. Arsic
    Univ Belgrade, Inst Microbiol & Immunol, Sch Med, Belgrade, Serbia.;Univ Children Hosp, Belgrade, Serbia..
    Artaman, Al
    Univ Manitoba, Winnipeg, MB, Canada..
    Asayesh, Hamid
    Qom Univ Med Sci, Sch Paramed, Dept Emergency Med, Qom, Iran..
    Asghar, Rana Jawad
    South Asian Publ Hlth Forum, Islamabad, Pakistan..
    Avokpaho, Euripide Frinel G. Arthur
    Inst Rech Clin Benin, Cotonou, Benin.;Lab dEtud & Rech Action Sante LERAS Afr, Parakou, Benin..
    Awasthi, Ashish
    Sanjay Gandhi Postgrad Inst Med Sci, Lucknow, Uttar Pradesh, India..
    Quintanilla, Beatriz Paulina Ayala
    Trobe Univ, Judith Lumley Ctr Mother, Infant & Family Hlth Res, Melbourne, Vic, Australia.;Peruvian Natl Inst Hlth, Lima, Peru..
    Azzopardi, Peter
    Murdoch Childrens Res Inst, Melbourne, Vic, Australia.;Dept Paediat, Melbourne, Vic, Australia.;South Australian Hlth & Med Res Inst, Wardliparingga Aboriginal Res Unit, Adelaide, SA, Australia..
    Bacha, Umar
    Univ Management & Technol, Sch Hlth Sci, Lahore, Pakistan..
    Badawi, Alaa
    Fac Med, Dept Nutrit Sci, Toronto, ON, Canada.;Publ Hlth Agcy Canada, Toronto, ON, Canada..
    Balakrishnan, Kalpana
    Sri Ramachandra Univ, Dept Environm Hlth Engn, Chennai, Tamil Nadu, India..
    Banerjee, Amitava
    Farr Inst Hlth Informat Res, London, England..
    Barac, Aleksandra
    Univ Belgrade, Fac Med, Belgrade, Serbia..
    Barker-Collo, Suzanne L.
    Univ Auckland, Sch Psychol, Auckland, New Zealand..
    Barnighausen, Till
    Harvard Univ, Harvard T H Chan Sch Publ Hlth, Boston, MA 02115 USA.;Africa Hlth Res Inst, Mtubatuba, South Africa.;Heidelberg Univ, Inst Publ Hlth, Heidelberg, Germany..
    Barregard, Lars
    Univ Gothenburg, Dept Occupat & Environm Hlth, Gothenburg, Sweden..
    Barrero, Lope H.
    Pontificia Univ Javeriana, Sch Engn, Dept Ind Engn, Bogota, Colombia..
    Basu, Sanjay
    Stanford Univ, Stanford, CA 94305 USA..
    Bayou, Tigist Assefa
    Mekelle Univ, Mekelle, Ethiopia..
    Beardsley, Justin
    Univ Oxford, Ho Chi Minh City, Oxford, Vietnam..
    Bedi, Neeraj
    Coll Publ Hlth & Trop Med, Jazan, Saudi Arabia..
    Beghi, Ettore
    IRCCS Ist Ric Farmacol Mario Negri, Milan, Italy..
    Bell, Brent
    Bell, Michelle L.
    Yale Univ, New Haven, CT USA..
    Benjet, Corina
    Natl Inst Psychiat Ramon Fuente, Mexico City, DF, Mexico..
    Bennett, Derrick A.
    Univ Oxford, Oxford, England..
    Bensenor, Isabela M.
    Univ Sao Paulo, Sao Paulo, Brazil..
    Berhane, Adugnaw
    Debre Berhane Univ, Debre Berhan, Ethiopia..
    Bernabe, Eduardo
    Kings Coll London, London, England..
    Betsu, Balem Demtsu
    Mekelle Univ, Mekelle, Ethiopia..
    Beyene, Addisu Shunu
    Haramaya Univ, Harar, Ethiopia..
    Bhala, Neeraj
    Queen Elizabeth Hosp Birmingham, Birmingham, W Midlands, England.;Univ Otago Med Sch, Wellington, New Zealand..
    Bhansali, Anil
    Postgrad Inst Med Educ & Res, Chandigarh, India..
    Bhatt, Samir
    Imperial Coll London, London, England..
    Biadgilign, Sibhatu
    Independent Publ Hlth Consultants, Addis Ababa, Ethiopia..
    Bienhofff, Kelly
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Bikbov, Boris
    Acad Shumakov Fed Res Ctr Transplantol & Artifici, Dept Nephrol Issues Transplanted Kidney, Moscow, Russia..
    Bin Abdulhak, Aref A.
    Univ Iowa Hosp & Clin, Iowa City, IA 52242 USA..
    Bisanzio, Donal
    Univ Oxford, Nuffield Dept Med, Oxford, England..
    Bjertness, Espen
    Univ Oslo, Dept Community Med, Oslo, Norway..
    Blore, Jed D.
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Borschmann, Rohan
    Murdoch Childrens Res Inst, Melbourne, Vic, Australia.;Univ Melbourne, Melbourne, Vic, Australia..
    Boufous, Soufiane
    Transport & Rd Safety TARS Res, Kensington, NSW, Australia..
    Bourne, Rupert R. A.
    Anglia Ruskin Univ, Vision Eye Res Unit, Cambridge, England..
    Brainin, Michael
    Danube Univ Krems, Krems, Austria..
    Brazinova, Alexandra
    Trnava Univ, Fac Hlth Sci & Social Work, Dept Publ Hlth, Trnava, Slovakia.;Int Neurotrauma Res Org, Vienna, Austria..
    Breitborde, Nicholas J. K.
    Ohio State Univ, Columbus, OH 43210 USA. German Canc Res Ctr, Heidelberg, Germany..
    Brugha, Traolach S.
    Univ Leicester, Leicester, Leics, England..
    Buchbinder, Rachelle
    Monash Univ, Dept Epidemiol & Prevent Med, Sch Publ Hlth & Prevent Med, Melbourne, Vic, Australia.;Cabrini Inst, Monash Dept Clin Epidemiol, Melbourne, Vic, Australia..
    Buckle, Geoffrey Colin
    Univ Calif San Francisco, San Francisco, CA USA..
    Butt, Zahid A.
    Shifa Trust Eye Hosp, Rawalpindi, Pakistan..
    Calabria, Bianca
    Australian Natl Univ, Natl Ctr Epidemiol & Populat Hlth, Canberra, ACT, Australia.;Univ New S Wales, Kensington, NSW, Australia..
    Campos-Nonato, Ismael Ricardo
    Harvard Univ, Harvard T H Chan Sch Publ Hlth, Boston, MA 02115 USA.;Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico..
    Campuzano, Julio Cesar
    Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico..
    Carabin, Helene
    Univ Oklahoma Hlth Sci Ctr, Dept Biostat & Epidemiol, Oklahoma City, OK USA..
    Carapetis, Jonathan R.
    Univ Western Australia, Telethon Kids Inst, Princess Margaret Hosp Children, Subiaco, WA, Australia..
    Cardenas, Rosario
    Metropolitan Autonomous Univ, Mexico City, DF, Mexico..
    Carrero, Juan Jesus
    Karolinska Inst, Dept Clin Sci Intervent & Technol, Stockholm, Sweden..
    Castaneda-Orjuela, Carlos A.
    Colombian Natl Hlth Observ, Inst Nacl Salud, Bogota, Colombia.;Univ Nacl Colombia, Epidemiol & Publ Hlth Evaluat Grp, Dept Publ Hlth, Bogota, Colombia..
    Rivas, Jacqueline Castillo
    Caja Costarricense Seguro Social, San Jose, Costa Rica.;Univ Costa Rica, San Pedro, Montes De Oca, Costa Rica..
    Catala-Lopez, Ferran
    Univ Valencia, Dept Med, INCLIVA Hlth Res Inst & CIBERSAM, Valencia, Spain.;Ottawa Hosp Res Inst, Clin Epidemiol Program, Ottawa, ON, Canada..
    Cavalleri, Fiorella
    Fac Med, Montevideo, Uruguay..
    Chang, Jung-Chen
    Natl Taiwan Univ, Sch Nursing, Coll Med, Taipei, Taiwan..
    Chiang, Peggy Pei-Chia
    Clin Governance Unit, Gold Coast Hlth, Southport, Qld, Australia..
    Chibalabala, Mirriam
    Crowd Watch Afr, Lusaka, Zambia..
    Chibueze, Chioma Ezinne
    Natl Ctr Child Hlth & Dev, Tokyo, Japan..
    Chisumpa, Vesper Hichilombwe
    Univ Zambia, Lusaka, Zambia.;Univ Witwatersrand, Johannesburg, South Africa..
    Choi, Jee-Young Jasmine
    Seoul Natl Univ Med Lib, Seoul, South Korea..
    Choudhury, Lincoln
    World Bank, New Delhi, India..
    Christensen, Hanne
    Bispebjerg Hosp, Copenhagen, Denmark..
    Ciobanu, Liliana G.
    Univ Adelaide, Adelaide, SA, Australia..
    Colistro, Valentina
    Univ Republica, Montevideo, Uruguay.;Ministerio Salud Publ, Montevideo, Uruguay..
    Colomar, Mercedes
    UNICEM, Montevideo, Uruguay..
    Colquhoun, Samantha M.
    Murdoch Childrens Res Inst, Melbourne, Vic, Australia..
    Cortinovis, Monica
    IRCCS Ist Ric Farmacol Mario Negri, Milan, Italy..
    Crump, John A.
    Univ Otago, Ctr Int Hlth, Dunedin Sch Med, Dunedin, New Zealand..
    Damasceno, Albertino
    Eduardo Mondlane Univ, Fac Med, Maputo, Mozambique..
    Dandona, Rakhi
    Publ Hlth Fdn India, New Delhi, India..
    Dargan, Paul I.
    Guys & St Thomas NHS Fdn Trust, London, England..
    Das Neves, Jose
    Univ Porto, Inst Invest Inovacao Sande I3S, Oporto, Portugal.;Univ Porto, INEB Inst Engn Biomed, Oporto, Portugal..
    Davey, Gail
    Wellcome Trust Brighton Sussex Ctr Global Hlth Re, Brighton, E Sussex, England..
    Davis, Adrian C.
    Publ Hlth England, London, England..
    De Leo, Diego
    Griffith Univ, Brisbane, Qld, Australia..
    Degenhardt, Louisa
    Natl Drug & Alcohol Res Ctr, Kensington, NSW, Australia..
    Del Gobbo, Liana C.
    Stanford Univ, Stanford, CA 94305 USA..
    Derrett, Sarah
    Univ Otago, Injury Prevent Res Unit, Dept Prevent & Social Med, Dunedin Sch Med, Dunedin, New Zealand..
    Des Jarlais, Don C.
    Mt Sinai Beth Israel, New York, NY USA.;Icahn Sch Med Mt Sinai, New York, NY USA..
    Deveber, Gabrielle A.
    Hosp Sick Children, Toronto, ON, Canada..
    Dharmaratne, Samath D.
    Univ Peradeniya, Dept Community Med, Fac Med, Peradeniya, Sri Lanka..
    Dhillon, Preet K.
    Publ Hlth Fdn India, Gurgaon, India.;Publ Hlth Fdn India, Gurgaon, India..
    Ding, Eric L.
    Harvard Univ, Harvard T H Chan Sch Publ Hlth, Boston, MA 02115 USA..
    Doyle, Kerrie E.
    RMIT Univ, Bundoora, Vic, Australia..
    Driscoll, Tim R.
    Sydney Sch Publ Hlth, Sydney, NSW, Australia..
    Duan, Leilei
    Natl Ctr Chron & Noncommunicable Dis Control & Pr, Beijing, Peoples R China..
    Dubey, Manisha
    Int Inst Populat Sci, Mumbai, Maharashtra, India..
    Duncan, Bruce Bartholow
    Univ Fed Rio Grande do Sul, Porto Alegre, RS, Brazil.;Univ N Carolina, Chapel Hill, NC USA..
    Ebrahimi, Hedyeh
    Endocrinol & Metab Populat Sci Inst, Non Communicable Dis Res Ctr, Tehran, Iran.;Shariati Hosp, Digest Dis Res Inst, Liver & Pancreaticobiliary Dis Res Ctr, Tehran, Iran..
    Ellenbogen, Richard G.
    Harborview UW Med, Seattle, WA USA..
    Elyazar, Iqbal
    Eijkman Oxford Clin Res Unit, Jakarta, Indonesia..
    Endries, Aman Yesuf
    Arba Minch Univ, Arba Minch, Ethiopia..
    Ermakov, Sergey Petrovich
    Russian Acad Sci, Inst Social & Econ Studies Populat, Moscow, Russia.;Russian Federat, Fed Res Inst Hlth Org & Informat, Minist Hlth, Moscow, Russia..
    Eshrati, Babak
    Minist Hlth & Med Educ, Tehran, Iran.;Arak Univ Med Sci, Arak, Iran..
    Esteghamati, Alireza
    Endocrinol & Metab Populat Sci Inst, Non Communicable Dis Res Ctr, Tehran, Iran..
    Estep, Kara
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Fahimi, Saman
    Digest Dis Res Inst, Tehran, Iran..
    Farid, Talha A.
    Univ Louisville, Louisville, KY 40292 USA..
    Sa Farinha, Carla Sofia e
    DGS Directorate Gen Hlth, Lisbon, Portugal.;Univ Aberta, Lisbon, Portugal..
    Faro, Andre
    Univ Fed Sergipe, Aracaju, Brazil..
    Farvid, Maryam S.
    Harvard Univ, Harvard T H Chan Sch Publ Hlth, Boston, MA 02115 USA.;Massachusetts Gen Hosp, Mongan Inst Hlth Policy, Harvard MGH Ctr Genom, Vulnerable Populat & Hlth Disparities, Boston, MA USA..
    Farzadfar, Farshad
    Endocrinol & Metab Populat Sci Inst, Non Communicable Dis Res Ctr, Tehran, Iran..
    Feigin, Valery L.
    Natl Inst Stroke & Appl Neurosci, Auckland, New Zealand..
    Fereshtehnejad, Seyed-Mohammad
    Karolinska Inst, Dept Neurobiol Care Sci & Soc NVS, Stockholm, Sweden..
    Fernandes, Jefferson G.
    Inst Educ & Sci, German Hosp Oswaldo Cruz, Sao Paulo, Brazil..
    Fernandes, Joao C.
    Queen Mary Univ London, William Harvey Res Inst, Barts & London Sch Med Dent, Ctr Expt Med Rheumatol, London, England..
    Fischer, Florian
    Univ Bielefeld, Bielefeld, Germany..
    Fitchett, Joseph R. A.
    Harvard Univ, Boston, MA 02115 USA..
    Foigt, Nataliya
    Acad Med Sci, Inst Gerontol, Kiev, Ukraine..
    Fowkes, F. Gerry R.
    Univ Edinburgh, Edinburgh, Midlothian, Scotland..
    Franklin, Richard C.
    James Cook Univ, Townsville, Qld, Australia..
    Friedman, Joseph
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Frostad, Joseph
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Furst, Thomas
    Swiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, Basel, Switzerland.;Univ Basel, Basel, Switzerland.;Imperial Coll London, Dept Infect Dis Epidemiol, London, England..
    Futran, Neal D.
    Univ Washington, Seattle, WA 98195 USA..
    Gabbe, Belinda
    Monash Univ, Dept Epidemiol & Prevent Med, Sch Publ Hlth & Prevent Med, Melbourne, Vic, Australia..
    Gankpe, Fortune Gbetoho
    Lab dEtud & Rech Action Sante LERAS Afr, Parakou, Benin.;CHU Hassan II, Fes, Morocco..
    Garcia-Basteiro, Alberto L.
    Manh Hlth Res Ctr, Manhica, Mozambique.;Barcelona Inst Global Hlth, Barcelona, Spain..
    Gebrehiwot, Tsegaye Tewelde
    Jimma Univ, Jimma, Ethiopia..
    Gebremedhin, Amanuel Tesfay
    Jimma Univ, Jimma, Ethiopia.;Univ Munich, Munich, Germany..
    Geleijnse, Johanna M.
    Wageningen Univ, Div Human Nutr, Wageningen, Netherlands..
    Gibney, Katherine B.
    Univ Melbourne, Peter Doherty Inst Infect & Immun, Melbourne, Vic, Australia.;Royal Melbourne Hosp, Melbourne, Vic, Australia..
    Gillum, Richard F.
    Howard Univ, Coll Med, Washington, DC USA..
    Ginawi, Ibrahim Abdelmageem Mohamed
    Univ Hail, Coll Med, Hail, Saudi Arabia..
    Giref, Ababi Zergaw
    Univ Children Hosp, Belgrade, Serbia.;Univ Addis Ababa, Addis Ababa, Ethiopia..
    Giroud, Maurice
    Univ Hosp Dijon, Dijon, France..
    Gishu, Melkamu Dedefo
    Haramaya Univ, Dire Dawa, Ethiopia.;Kersa Hlth & Demog Surveillance Syst, Harar, Ethiopia..
    Godwin, William W.
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Gomez-Dantes, Hector
    Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico..
    Gona, Philimon
    Univ Massachusetts, Boston, MA USA..
    Goodridge, Amador
    Inst Invest Cient Serv Alta Tecnol, INDICASAT AIP, Ciudad Del Saber, Panama..
    Gopalani, Sameer Vali
    Govt Federated States Micronesia, Dept Hlth & Social Affairs, Palikir, Micronesia..
    Gotay, Carolyn C.
    Univ British Columbia, Vancouver, BC, Canada..
    Goto, Atsushi
    Div Epidemiol, Ctr Publ Hlth Sci, Tokyo, Japan..
    Gouda, Hebe N.
    Univ Queensland, Brisbane, Qld, Australia..
    Guo, Yuming
    Univ Queensland, Brisbane, Qld, Australia..
    Gupta, Rahul
    West Virginia Bur Publ Hlth, Charleston, WV USA..
    Gupta, Rajeev
    Eternal Heart Care Ctr & Res Inst, Jaipur, Rajasthan, India..
    Gupta, Vipin
    Univ Delhi, Dept Anthropol, Delhi, India..
    Gutierrez, Reyna A.
    Natl Inst Psychiat Ramon Fuente, Mexico City, DF, Mexico..
    Hafezi-Nejad, Nima
    Endocrinol & Metab Populat Sci Inst, Non Communicable Dis Res Ctr, Tehran, Iran..
    Haile, Demewoz
    Univ Addis Ababa, Addis Ababa, Ethiopia..
    Hailu, Alemayehu Desalegne
    Univ Addis Ababa, Sch Publ Hlth, Addis Ababa, Ethiopia.;Univ Bergen, Bergen, Norway..
    Hailu, Gessessew Bugssa
    Mekelle Univ, Mekelle, Ethiopia.;Kilte Awlaelo Hlth & Demog Surveillance Syst, Mekelle, Ethiopia..
    Halasa, Yara A.
    Brandeis Univ, Waltham, MA USA..
    Ribhi, Randah
    Hamadeh,
    Hamidi, Samer
    Hamdan Bin Mohammed Smart Univ, Dubai, U Arab Emirates..
    Hammami, Mouhanad
    Wayne Cty Dept Hlth & Human Serv, Detroit, MI USA..
    Handal, Alexis J.
    Univ New Mexico, Albuquerque, NM USA..
    Hankey, Graeme J.
    Inst Hlth Metr & Evaluat, Seattle, WA USA.;Univ Western Australia, Sch Med & Pharmacol, Perth, WA, Australia.;Harry Perkins Inst Med Res, Nedlands, WA, Australia.;Western Australian Neurosci Res Inst, Nedlands, WA, Australia..
    Harb, Hilda L.
    Minist Publ Hlth, Beirut, Lebanon..
    Harikrishnan, Sivadasanpillai
    Sree Chitra Tirunal Inst Med Sci & Technol, Trivandrum, Kerala, India..
    Haro, Josep Maria
    Parc Sanitari Sant Joan Deu CIBERSAM, Barcelona, Spain.;Univ Barcelona, Barcelona, Spain..
    Hassanvand, Mohammad Sadegh
    Inst Environm Res, Ctr Air Pollut Res, Tehran, Iran..
    Hassen, Tahir Ahmed
    Haramaya Univ, Harar, Ethiopia..
    Havmoeller, Rasmus
    Karolinska Inst, Stockholm, Sweden..
    Hay, Roderick J.
    Kings Coll London, London, England.;Int Fdn Dermatol, London, England..
    Hedayati, Mohammad T.
    Mazandaran Univ Med Sci, Sch Med, Dept Med Mycol & Parasitol, Sari, Iran..
    Heredia-Pi, Ileana Beatriz
    Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico..
    Heydarpour, Pouria
    Multiple Sclerosis Res Ctr Neurosci Inst, Tehran, Iran..
    Hoek, Hans W.
    Univ Med Ctr Groningen, Dept Psychiat, Groningen, Netherlands.;Columbia Univ, Dept Epidemiol, Mailman Sch Publ Hlth, New York, NY USA..
    Hoffman, Daniel J.
    Rutgers State Univ, New Brunswick, NJ USA..
    Horino, Masako
    Nevada Div Publ & Behav Hlth, Dept Hlth & Human Serv, Carson City, NV USA..
    Horita, Nobuyuki
    Yokohama City Univ, Dept Pulmonol, Grad Sch Med, Yokohama, Kanagawa, Japan..
    Hosgood, H. Dean
    Albert Einstein Coll Med, Bronx, NY USA..
    Hoy, Damian G.
    Publ Hlth Div, Pacific Community, Noumea, New Caledonia..
    Hsairi, Mohamed
    Salah Azaiz Inst, Dept Epidemiol, Tunis, Tunisia..
    Huang, Hsiang
    Cambridge Hlth Alliance, Cambridge, MA USA..
    Huang, John J.
    Yale Univ, New Haven, CT USA..
    Iburg, Kim Moesgaard
    Aarhus Univ, Aarhus, Denmark..
    Idrisov, Bulat T.
    Boston Univ, Boston Med Ctr, Boston, MA USA..
    Innos, Kaire
    Natl Inst Hlth Dev, Tallinn, Estonia..
    Inoue, Manami
    Natl Canc Ctr, Tokyo, Japan.;Univ Tokyo, Grad Sch Med, Tokyo, Japan..
    Jacobsen, Kathryn H.
    George Mason Univ, Dept Global & Community Hlth, Fairfax, VA 22030 USA..
    Jauregui, Alejandra
    Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico..
    Jayatilleke, Achala Upendra
    Postgrad Inst Med, Colombo, Sri Lanka.;Inst Violence & Injury Prevent, Colombo, Sri Lanka..
    Jeemon, Panniyammakal
    Ctr Control Chron Condit, New Delhi, India.;Ctr Control Chron Condit, Gurgaon, India.;Ctr Chron Dis Control, New Delhi, India..
    Jha, Vivekanand
    Univ Oxford, Oxford, England.;George Inst Global Hlth India, New Delhi, India..
    Jiang, Guohong
    Tianjin Ctr Dis Control & Prevent, Tianjin, Tianjin, Peoples R China..
    Jiang, Ying
    Univ Occupat & Environm Hlth, Inst Ind Ecol Sci, Dept Hlth Dev, Kitakyushu, Fukuoka, Japan..
    Jibat, Tariku
    Wageningen Univ, Wageningen, Netherlands.;Univ Addis Ababa, Addis Ababa, Ethiopia..
    Jimenez-Corona, Aida
    Inst Ophthalmol Conde Valencia, Dept Ocular Epidemiol & Visual Hlth, Mexico City, DF, Mexico.;Gen Directorate Epidemiol, Minist Hlth, Mexico City, DF, Mexico..
    Jin, Ye
    Natl Ctr Chron & Noncommunicable Dis Control & Pr, Beijing, Peoples R China..
    Jonas, Jost B.
    Heidelberg Univ, Med Fac Mannheim, Dept Ophthalmol, Mannheim, Germany..
    Kabir, Zubair
    Univ Coll Cork, Cork, Ireland..
    Kajungu, Dan K.
    Sante Stat Analyt Res Inst, Kampala, Uganda.;Mildmay Uganda, Kampala, Uganda..
    Kalkonde, Yogeshwar
    Action & Res Community Hlth, Soc Educ, Gadchiroli, India..
    Kamal, Ritul
    CSIR Indian Inst Toxicol Res, Lucknow, Uttar Pradesh, India..
    Kan, Haidong
    Fudan Univ, Shanghai, Peoples R China..
    Kandel, Amit
    SUNY Buffalo, Buffalo, NY USA..
    Karch, Andre
    Helmholtz Ctr Infect Res, Epidemiol & Stat Methods Res Grp, Braunschweig, Germany.;German Ctr Infect Res, Hannover Braunschweig Site, Hannover, Germany..
    Karema, Corine Kakizi
    Swiss Trop & Publ Hlth Inst, Basel, Switzerland.;Qual & Equity Hlth Care, Kigali, Rwanda..
    Karimkhani, Chante
    Case Western Univ Hosp, Cleveland, OH USA..
    Kasaeian, Amir
    Endocrinol & Metab Populat Sci Inst, Non Communicable Dis Res Ctr, Tehran, Iran.;Hematol Oncol & Stem Cell Transplantat Res Ctr, Tehran, Iran..
    Katibeh, Marzieh
    Shahid Beheshti Univ Med Sci, Ophthalm Epidemiol Res Ctr, Tehran, Iran..
    Kaul, Anil
    Oklahoma State Univ, Tulsa, OK USA..
    Kawakami, Norito
    Univ Tokyo, Sch Publ Hlth, Tokyo, Japan..
    Kazi, Dhruv S.
    Univ Calif San Francisco, San Francisco, CA 94143 USA..
    Keiyoro, Peter Njenga
    Inst Trop & Infect Dis, Nairobi, Kenya.;Sch Continuing & Distance Educ, Nairobi, Kenya..
    Kemp, Andrew Haddon
    Univ Sydney, Sydney, NSW, Australia.;Swansea Univ, Swansea, W Glam, Wales..
    Kengne, Andre Pascal
    South African Med Res Council, Cape Town, South Africa.;Univ Cape Town, Cape Town, South Africa..
    Keren, Andre
    Assuta Hosp, Assuta Hashalom, Tel Aviv, Israel..
    Kesavachandran, Chandrasekharan Nair
    CSIR Indian Inst Toxicol Res, Lucknow, Uttar Pradesh, India..
    Khader, Yousef Saleh
    Jordan Univ Sci & Technol, Irbid, Jordan..
    Khan, Abdur Rahman
    Univ Louisville, Louisville, KY 40292 USA..
    Khan, Ejaz Ahmad
    Hlth Serv Acad, Islamabad, Pakistan..
    Khang, Young-Ho
    Seoul Natl Univ, Coll Med, Seoul, South Korea..
    Khoja, Tawfik Ahmed Muthafer
    Execut Board Hlth Minist Council Cooperat Council, Riyadh, Saudi Arabia..
    Khubchandani, Jagdish
    Ball State Univ, Muncie, IN 47306 USA..
    Kieling, Christian
    Univ Fed Rio Grande do Sul, Porto Alegre, RS, Brazil.;Hosp Clin Porto Alegre, Porto Alegre, RS, Brazil..
    Kim, Cho-il
    Korea Hlth Ind Dev Inst, Cheongju, South Korea..
    Kim, Daniel
    Northeastern Univ, Dept Hlth Sci, Boston, MA USA..
    Kim, Yun Jin
    Southern Univ Coll, Skudai, Malaysia..
    Kissoon, Niranjan
    Univ British Columbia, Vancouver, BC, Canada..
    Kivipelto, Miia
    Karolinska Inst, Aging Res Ctr, Stockholm, Sweden..
    Knibbs, Luke D.
    Univ Queensland, Sch Publ Hlth, Brisbane, Qld, Australia..
    Knudsen, Ann Kristin
    Univ Bergen, Dept Global Publ Hlth & Primary Care, Bergen, Norway.;Ctr Dis Burden, Oslo, Norway..
    Kokubo, Yoshihiro
    Natl Cerebral & Cardiovasc Ctr, Dept Prevent Cardiol, Suita, Osaka, Japan..
    Kolte, Dhaval
    Brown Univ, Div Cardiol, Providence, RI USA..
    Kopec, Jacek A.
    Univ British Columbia, Vancouver, BC, Canada..
    Koul, Parvaiz A.
    Sherikashmir Inst Med Sci, Srinagar, Jammu & Kashmir, India..
    Koyanagi, Ai
    Parc Sanitari Sant Joan Deu CIBERSAM, Res Dev Unit, Barcelona, Spain..
    Defo, Barthelemy Kuate
    Univ Montreal, Dept Demog, Montreal, PQ, Canada.;Univ Montreal, Publ Hlth Res Inst, Montreal, PQ, Canada.;Univ Montreal, Dept Social & Prevent Med, Sch Publ Hlth, Montreal, PQ, Canada..
    Kuchenbecker, Ricardo S.
    Univ Fed Rio Grande do Sul, Grad Studies Epidemiol, Porto Alegre, RS, Brazil..
    Bicer, Burcu Kucuk
    Hacettepe Univ, Inst Publ Hlth, Ankara, Turkey..
    Kuipers, Ernst J.
    Univ Med Ctr Rotterdam, Erasmus MC, Rotterdam, Netherlands..
    Kumar, G. Anil
    Publ Hlth Fdn India, New Delhi, India..
    Kwan, Gene F.
    Boston Univ, Sch Med, Boston, MA USA..
    Lalloo, Ratilal
    Univ Queensland, Sch Dent, Brisbane, Qld, Australia..
    Lallukka, Tea
    Work Org, Work Disabil Prevent, Finnish Inst Occupat Hlth, Helsinki, Finland.;Univ Helsinki, Dept Publ Hlth, Fac Med, Helsinki, Finland..
    Larsson, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    Latif, Asma Abdul
    Lahore Coll Women Univ, Dept Zool, Lahore, Pakistan..
    Lavados, Pablo M.
    Univ Desarrollo, Clin Alemana, Serv Neurol, Santiago, Chile..
    Lawrynowicz, Alicia Elena Beatriz
    Inst Nacl Epidemiol Dr Juan H Jara, Mar Del Plata, Argentina..
    Leasher, Janet L.
    Nova SE Univ, Coll Optometry, Ft Lauderdale, Ft Lauderdale, FL USA..
    Leigh, James
    Univ Sydney, Sydney, NSW, Australia..
    Leung, Ricky
    SUNY Albany, Albany, NY USA..
    Li, Yichong
    Natl Ctr Chron & Noncommunicable Dis Control & Pr, Beijing, Peoples R China.;San Francisco VA Med Ctr, San Francisco, CA USA..
    Li, Yongmei
    Lipshultz, Steven E.
    Wayne State Univ, Sch Med, Detroit, MI USA.;Childrens Hosp Michigan, Detroit, MI 48201 USA..
    Liu, Patrick Y.
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Liu, Yang
    Emory Univ, Atlanta, GA USA..
    Lloyd, Belinda K.
    Monash Univ, Eastern Hlth Clin Sch, Melbourne, Vic, Australia.;Turning Point, Eastern Hlth, Melbourne, Vic, Australia..
    Logroscino, Giancarlo
    Univ Bari, Bari, Italy..
    Looker, Katharine J.
    Univ Bristol, Bristol, Avon, England..
    Lotufo, Paulo A.
    Univ Sao Paulo, Sao Paulo, Brazil..
    Lucas, Robyn M.
    Australian Natl Univ, Natl Ctr Epidemiol & Populat Hlth, Canberra, ACT, Australia..
    Lunevicius, Raimundas
    Aintree Univ, Hosp Natl Hlth Serv Fdn Trust, Liverpool, Merseyside, England.;Univ Liverpool, Sch Med, Liverpool, Merseyside, England..
    Lyons, Ronan A.
    Farr Inst, Swansea, W Glam, Wales..
    El Razek, Hassan Magdy Abd
    Mansoura Fac Med, Mansoura, Egypt. Social Secur Org Res Inst, Tehran, Iran..
    Mandavi, Mandi
    Majdan, Marek
    Trnava Univ, Fac Hlth Sci & Social Work, Dept Publ Hlth, Trnava, Slovakia..
    Majeed, Azeem
    Imperial Coll London, London, England..
    Malekzadeh, Reza
    Digest Dis Res Inst, Tehran, Iran..
    Malta, Deborah Carvalho
    Univ Fed Minas Gerais, Belo Horizonte, MG, Brazil..
    Marcenes, Wagner
    Kings Coll London, Div Populat & Patient Hlth, Inst Dent, London, England..
    Martinez-Raga, Jose
    Univ Valencia, Univ Hosp Doctor Peset, Valencia, Spain.;CEU Cardenal Herrera Univ, Valencia, Spain..
    Masiye, Felix
    Inst Hlth Metr & Evaluat, Seattle, WA USA.;Univ Zambia, Lusaka, Zambia..
    Mason-Jones, Amanda J.
    Univ York, Dept Hlth Sci, York, N Yorkshire, England..
    Matzopoulos, Richard
    South African Med Res Council, Cape Town, South Africa.;Univ Cape Town, Sch Publ Hlth & Family Med, Cape Town, South Africa..
    Mayosi, Bongani M.
    Univ Cape Town, Cape Town, South Africa..
    McGrath, John J.
    Univ Queensland, Brisbane, Qld, Australia..
    Mckee, Martin
    Erasmus Univ, Inst Hlth Policy & Management, Rotterdam, Netherlands.;London Sch Hyg Trop Med, London, England..
    Meaney, Peter A.
    Univ Penn, Perelman Sch Med, Philadelphia, PA USA.;Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA..
    Mehari, Alem
    Howard Univ, Coll Med, Washington, DC USA..
    Melaku, Yohannes Adama
    Univ Adelaide, Sch Med, Adelaide, SA, Australia.;Mekelle Univ, Sch Publ Hlth, Mekelle, Ethiopia..
    Memiah, Peter
    Univ Florida, Pensacola, FL USA..
    Memish, Ziad A.
    Saudi Minist Hlth, Riyadh, Saudi Arabia.;Alfaisal Univ, Coll Med, Riyadh, Saudi Arabia..
    Mendoza, Walter
    United Nations Populat Fund, Lima, Peru..
    Meretoja, Atte
    Dept Med, Melbourne, Vic, Australia.;Helsinki Univ Hosp, Dept Neurol, Helsinki, Finland..
    Meretoja, Tuomo J.
    Univ Helsinki, Helsinki, Finland.;Helsinki Univ Hosp, Breast Surg Unit, Ctr Comprehens Canc, Helsinki, Finland..
    Mesfin, Yonatan Moges
    Haramaya Univ, Harar, Ethiopia..
    Mhimbira, Francis Apolinary
    Ifakara Hlth Inst, Bagamoyo, Tanzania..
    Miller, Ted R.
    Pacific Inst Res Evaluat, Calverton, MD USA.;Curtin Univ, Ctr Populat Hlth, Perth, WA, Australia..
    Mills, Edward J.
    Univ Ottawa, Ottawa, ON, Canada..
    Mirarefin, Mojde
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Mirrakhimov, Erkin M.
    Kyrgyz State Med Acad, Bishkek, Kyrgyzstan.;Natl Ctr Cardiol & Internal Dis, Bishkek, Kyrgyzstan..
    Mitchell, Philip B.
    Univ New S Wales, Kensington, NSW, Australia..
    Mock, Charles N.
    Harborview Injury Prevent & Res Ctr, Seattle, WA USA..
    Mohammad, Karzan Abdulmuhsin
    Univ Salahaddin, Erbil, Iraq..
    Mohammadi, Alireza
    Baqiyatallah Univ Med Sci, Neurosci Res Ctr, Tehran, Iran..
    Mohammed, Shafiu
    Heidelberg Univ, Inst Publ Hlth, Heidelberg, Germany.;Ahmadu Bello Univ, Hlth Syst & Policy Res Unit, Zaria, Nigeria..
    Monasta, Lorenzo
    IRCCS Burlo Garofolo, Inst Maternal & Child Hlth, Trieste, Italy..
    Montanez Hernandez, Julio Cesar
    Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico..
    Montico, Marcella
    IRCCS Burlo Garofolo, Inst Maternal & Child Hlth, Trieste, Italy..
    Moradi-Lakeh, Maziar
    Inst Hlth Metr & Evaluat, Seattle, WA USA.;Iran Univ Med Sci, Dept Community Med, Gastrointestinal & Liver Dis Res Ctr, Prevent Med & Publ Hlth Res Ctr, Tehran, Iran..
    Mori, Rintaro
    Natl Ctr Child Hlth & Dev, Tokyo, Japan..
    Mueller, Ulrich O.
    Fed Inst Populat Res, Wiesbaden, Germany..
    Mumford, John Everett
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Murdoch, Michele E.
    West Herts Hosp NHS Trust, Watford, England..
    Murthy, Gudlavalleti Venkata Satyanarayana
    London Sch Hyg Trop Med, London, England.;Indian Inst Publ Hlth, Gurgaon, India..
    Nachega, Jean B.
    Univ Pittsburgh, Grad Sch Publ Hlth, Pittsburgh, PA USA.;Univ Stellenbosch, Cape Town, South Africa.;Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA..
    Naheed, Aliya
    Int Ctr Diarrhoeal Dis Res, Dhaka, Bangladesh..
    Naldi, Luigi
    Azienda Osped Papa Giovanni XXIII, Bergamo, Italy..
    Nangia, Vinay
    Suraj Eye Inst, Nagpur, Maharashtra, India..
    Newton, John N.
    Publ Hlth England, London, England..
    Ng, Marie
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Ngalesoni, Frida Namnyak
    Minist Hlth & Social Welf, Dar Es Salaam, Tanzania..
    Le Nguyen, Quyen
    Duy Tan Univ, Inst Global Hlth Innovat, Da Nang, Vietnam..
    Nisar, Muhammad Imran
    Aga Khan Univ, Karachi, Pakistan..
    Pete, Patrick Martial Nkamedjie
    Inst Res, Socioecon Dev & Commun, Yaounde, Cameroon..
    Nolla, Joan M.
    Hosp Univ Bellvitge, Lhospitalet De Llobregat, Spain..
    Norheim, Ole F.
    Univ Bergen, Bergen, Norway..
    Norman, Rosana E.
    Queensland Univ Technol, Inst Hlth & Biomed Innovat, Brisbane, Qld, Australia..
    Norrving, Bo
    Lund Univ, Skane Univ Hosp, Dept Clin Sci Lund, Lund, Sweden..
    Obermeyer, Carla Makhlouf
    Amer Univ Beirut, Ctr Res Populat & Hlth, Fac Hlth Sci, Beirut, Lebanon..
    Ogbo, Felix Akpojene
    Univ Western Sydney, Ctr Hlth Res, Sydney, NSW, Australia..
    Oh, In-Hwan
    Kyung Hee Univ, Sch Med, Dept Prevent Med, Seoul, South Korea..
    Oladimeji, Olanrewaju
    Human Sci Res Council, Durban, South Africa.;Univ KwaZulu Natal, Durban, South Africa..
    Olivares, Pedro R.
    Univ Autonoma Chile, Talca, Chile..
    Olusanya, Bolajoko Olubukunola
    Ctr Healthy Start Initiat, Lagos, Nigeria..
    Olusanya, Jacob Olusegun
    Ctr Healthy Start Initiat, Lagos, Nigeria..
    Oren, Eyal
    Univ Arizona, Tucson, AZ USA..
    Ortiz, Alberto
    IIS Fdn Jimenez Diaz UAM, Madrid, Spain..
    Ota, Erika
    Lukes Int Univ, Tokyo, Japan..
    Oyekale, Abayomi Samuel
    Hypertens NorthWest Univ, Mafikeng, South Africa..
    Pa, Mahesh
    JSS Univ, JSS Med Coll, Mysore, Karnataka, India..
    Park, Eun-Kee
    Kosin Univ, Dept Med Human & Social Med, Coll Med, Busan, South Korea..
    Parsaeian, Mahboubeh
    Endocrinol & Metab Populat Sci Inst, Non Communicable Dis Res Ctr, Tehran, Iran.;Sch Publ Hlth, Dept Epidemiol & Biostat, Tehran, Iran..
    Patten, Scott B.
    Univ Calgary, Dept Community Hlth Sci, Calgary, AB, Canada..
    Patton, George C.
    Murdoch Childrens Res Inst, Melbourne, Vic, Australia..
    Pedro, Joao Mario
    Univ Porto, EPI Unit Inst Publ Hlth, Oporto, Portugal.;Hlth Res Ctr Angola, Caxito, Angola..
    Pereira, David M.
    Univ Porto, REQUIMTE LAQV, Lab Farm, Dept Quim,Fac Farm, Oporto, Portugal..
    Perico, Norberto
    IRCCS Ist Ric Farmacol Mario Negri, Bergamo, Italy..
    Pesudovs, Konrad
    Flinders Univ S Australia, Adelaide, SA, Australia..
    Petzold, Max
    Univ Gothenburg, Hlth Metr Unit, Gothenburg, Sweden.;Univ Witwatersrand, Johannesburg, South Africa..
    Phillips, Michael Robert
    Emory Univ, Atlanta, GA USA.;Shanghai Jiao Tong Univ, Sch Med, Shanghai, Peoples R China..
    Piel, Frederic B.
    Imperial Coll London, Dept Epidemiol & Biostat, London, England..
    Pillay, Julian David
    Durban Univ Technol, Durban, South Africa..
    Pishgar, Farhad
    Endocrinol & Metab Populat Sci Inst, Non Communicable Dis Res Ctr, Tehran, Iran.;Urooncol Res Ctr, Tehran, Iran..
    Plass, Dietrich
    Exposure Assessment & Environm Hlth Indicators, German Environm Agcy, Berlin, Germany..
    Polinder, Suzanne
    Erasmus MC, Dept Publ Hlth, Rotterdam, Netherlands..
    Popova, Svetlana
    Ctr Addict & Mental Hlth, Toronto, ON, Canada..
    Poulton, Richie G.
    Univ Otago, Dunedin, New Zealand..
    Pourmalek, Farshad
    Univ British Columbia, Vancouver, BC, Canada..
    Prasad, Noela M.
    Fred Hollows Fdn, Sydney, NSW, Australia.;Ctr Eye Res Australia, Melbourne, Vic, Australia..
    Qorbani, Mostafa
    Alborz Univ Med Sci, Sch Med, Dept Community Med, Karaj, Iran..
    Rabiee, Rynaz H. S.
    Karolinska Inst, Dept Publ Hlth Sci, Stockholm, Sweden..
    Radfar, Amir
    AT Still Univ, Kirksville, MO USA..
    Rafay, Anwar
    Contech Sch Publ Hlth, Lahore, Pakistan..
    Rahimi, Kazem
    Univ Oxford, Oxford, England..
    Rahimi-Movaghar, Vafa
    Sina Trauma & Surg Res Ctr, Tehran, Iran..
    Rahman, Mahfuzar
    Int Inst Populat Sci, Mumbai, Maharashtra, India.;Res & Evaluat Div, BRAC, Dhaka, Bangladesh..
    Rahman, Mohammad Hifz Ur
    Rahman, Sajjad Ur
    Hamad Med Corp, Doha, Qatar..
    Rai, Dheeraj
    Univ Bristol, Bristol, Avon, England..
    Rai, Rajesh Kumar
    Soc Hlth & Demog Surveillance, Suri, India..
    Rajsic, Sasa
    UMIT, ERAWEB Program, Hall In Tirol, Austria..
    Raju, Murugesan
    Univ Missouri, Columbia, MO USA..
    Ram, Usha
    Int Inst Populat Sci, Mumbai, Maharashtra, India..
    Ranganathan, Kavitha
    Univ Michigan Hlth Syst, Ann Arbor, MI USA..
    Refaat, Amany H.
    Walden Univ, Minneapolis, MN USA.;Suez Canal Univ, Ismailia, Egypt..
    Reitsma, Marissa B.
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Remuzzi, Giuseppe
    Azienda Osped Papa Giovanni XXIII, Bergamo, Italy.;IRCCS Ist Ric Farmacol Mario Negri, Bergamo, Italy.;Univ Milan, Dept Biomed & Clin Sci Sacco L, Milan, Italy..
    Resnikoff, Serge
    Brien Holden Vision Inst, Kensington, NSW, Australia..
    Reynolds, Alex
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Ribeiro, Antonio L.
    Univ Fed Minas Gerais, Hosp Clin, Belo Horizonte, MG, Brazil..
    Ricci, Stefano
    UO Neurol USL Umbria 1, Citta Di Castello, Italy..
    Roba, Hirbo Shore
    Haramaya Univ, Coll Hlth & Med Sci, Harar, Ethiopia.;Haramaya Univ, Coll Hlth & Med Sci, Dawa, Ethiopia..
    Rojas-Rueda, David
    Inst Salud Global Barcelona, Barcelona, Spain..
    Ronfani, Luca
    IRCCS Burlo Garofolo, Inst Maternal & Child Hlth, Trieste, Italy..
    Roshandel, Gholamreza
    Digest Dis Res Inst, Tehran, Iran.;Golestan Univ Med Sci, Golestan Res Ctr Gastroenterol & Hepatol, Gorgan, Iran..
    Roth, Gregory A.
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Roy, Ambuj
    All India Inst Med Sci, New Delhi, India..
    Sackey, Ben Benasco
    World Hlth Org, Accra, Ghana..
    Sagar, Rajesh
    All India Inst Med Sci, New Delhi, India..
    Sanabria, Juan R.
    Marshall Univ, Edwards Sch Med J, Huntington, WV USA.;Case Western Reserve Univ, Cleveland, OH USA..
    Dolores Sanchez-Nino, Maria
    IIS Fdn Jimenez Diaz, Madrid, Spain..
    Santos, Itamar S.
    Univ Sao Paulo, Dept Internal Med, Sao Paulo, Brazil..
    Santos, Joao Vasco
    Univ Porto, Oporto, Portugal..
    Sarmiento-Suarez, Rodrigo
    Univ Ciencias Aplicadas Ambient, Bogota, Colombia..
    Sartorius, Benn
    Univ KwaZulu Natal, Durban, South Africa..
    Satpathy, Maheswar
    All India Inst Med Sci, New Delhi, India..
    Savic, Miloje
    Norwegian Inst Publ Hlth, Oslo, Norway..
    Sawhney, Monika
    Marshall Univ, Huntington, WV USA..
    Schmidt, Maria Ines
    Univ Fed Rio Grande do Sul, Porto Alegre, RS, Brazil..
    Schneider, Ione J. C.
    Univ Fed Santa Catarina, Florianopolis, SC, Brazil..
    Schutte, Aletta E.
    HART, Mafikeng, South Africa.;South African Med Res Council, Potchefstroom, South Africa..
    Schwebel, David C.
    Univ Alabama Birmingham, Birmingham, AL USA..
    Seedat, Soraya
    Univ Stellenbosch, Cape Town, South Africa..
    Sepanlou, Sadaf G.
    Digest Dis Res Inst, Tehran, Iran..
    Servan-Mori, Edson E.
    Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico..
    Shahraz, Saeid
    Tufts Med Ctr, Boston, MA USA..
    Shaikh, Masood Ali
    Independent Consultant, Karachi, Pakistan..
    Sharma, Rajesh
    Indian Inst Technol Ropar, Rupnagar, India..
    She, Jun
    Zhongshan Hosp, Dept Pulm Med, Shanghai, Peoples R China..
    Sheikhbahaei, Sara
    Endocrinol & Metab Populat Sci Inst, Non Communicable Dis Res Ctr, Tehran, Iran..
    Shen, Jiabin
    Ohio State Univ, Coll Med, Columbus, OH 43210 USA.;Res Inst, Nationwide Childrens Hosp, Columbus, OH USA..
    Sheth, Kevin N.
    Yale Univ, Sch Med, New Haven, CT USA..
    Shibuya, Kenji
    Univ Tokyo, Tokyo, Japan..
    Shigematsu, Mika
    Natl Inst Infect Dis, Tokyo, Japan.;Sandia Natl Labs, Albuquerque, NM USA..
    Shin, Min-Jeong
    Korea Univ, Dept Publ Hlth Sci, Grad Sch, Seoul, South Korea..
    Shin, Rahman
    Work Org, Work Disabil Prevent, Finnish Inst Occupat Hlth, Helsinki, Finland..
    Sigfusdottir, Inga Dora
    Reykjavik Univ, Reykjavik, Iceland..
    Santos Silva, Diego Augusto
    Univ Fed Santa Catarina, Florianopolis, SC, Brazil..
    Silverberg, Jonathan I.
    Northwestern Univ, Feinberg Sch Med, Chicago, IL USA..
    Simard, Edgar P.
    Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA USA..
    Singh, Abhishek
    Int Inst Populat Sci, Mumbai, Maharashtra, India..
    Singh, Jasvinder A.
    Univ Alabama Birmingham, Birmingham, AL USA..
    Singh, Prashant Kumar
    Inst Human Dev, New Delhi, India..
    Skirbekk, Vegard
    Columbia Univ, New York, NY USA.;Norwegian Inst Publ Hlth, Oslo, Norway..
    Skogen, Jens Christoffer
    Norwegian Inst Publ Hlth, Dept Hlth Promot, Oslo, Norway.;Alcohol & Drug Res Western Norway, Stavanger, Norway..
    Soljak, Michael
    Imperial Coll London, London, England..
    Soreide, Kjetil
    Stavanger Univ Hosp, Stavanger, Norway..
    Sreeramareddy, Chandrashekhar T.
    Int Med Univ, Dept Community Med, Kuala Lumpur, Malaysia..
    Stathopoulou, Vasiliki
    Attikon Univ Hosp, Athens, Greece..
    Steel, Nicholas
    Publ Hlth England, London, England.;Univ Anglia, Norwich, Norfolk, England..
    Stein, Dan J.
    Univ Cape Town, Dept Psychiat, Cape Town, South Africa.;S African MRC, Unit Anxiety Stress Dis, Cape Town, South Africa..
    Stein, Murray B.
    Univ Calif San Diego, San Diego, CA USA..
    Steiner, Timothy J.
    Imperial Coll London, Div Brain Sci, London, England.;Norwegian Univ Sci & Technol, Dept Neurosci, Trondheim, Norway..
    Stovner, Lars Jacob
    Norwegian Univ Sci & Technol, Dept Neurosci, Trondheim, Norway.;St Olays Hosp, Norwegian Advisory Unit Headache, Trondheim, Norway..
    Stranges, Saverio
    LIH, Strassen, Luxembourg..
    Stroumpoulis, Konstantinos
    Alexandra Gen Hosp Athens, Athens, Greece.;Ctr Hosp Publ Cotentin, Cherbourg, France..
    Sunguya, Bruno F.
    Muhimbili Univ Hlth & Allied Sci, Dar Es Salaam, Tanzania..
    Sur, Patrick J.
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Swaminathan, Soumya
    Indian Council Med Res, New Delhi, India..
    Sykes, Bryan L.
    Univ Calif Irvine, Dept Criminol Law & Soc Sociol & Publ Hlth, Irvine, CA USA..
    Szoeke, Cassandra E. I.
    Inst Hlth & Ageing, Melbourne, Vic, Australia..
    Tabares-Seisdedos, Rafael
    Univ Valencia, Dept Med, INCLIVA Hlth Res Inst & CIBERSAM, Valencia, Spain..
    Landon, Nikhil
    Tanne, David
    Chaim Sheba Med Ctr, Tel Hashomer, Israel.;Tel Aviv Univ, Tel Aviv, Israel..
    Tavakkoli, Mohammad
    New York Med Coll, Valhalla, NY USA..
    Taye, Bineyam
    Colgate Univ, Dept Biol, Hamilton, NY USA..
    Taylor, Hugh R.
    Univ Melbourne, Melbourne, Vic, Australia..
    Ao, Braden J. Te
    Auckland Univ Technol, Auckland, New Zealand..
    Tegegne, Teketo Kassaw
    Debre Markos Univ, Debre Markos, Ethiopia..
    Tekle, Dejen Yemane
    Mekelle Univ, Mekelle, Ethiopia..
    Terkawi, Abdullah Sulieman
    Dept Anesthesiol, Riyadh, Saudi Arabia.;Univ Virginia, Dept Anesthesiol, Charlottesville, VA USA.;Cleveland Clin, Outcomes Res Consortium, Cleveland, OH USA..
    Tessema, Gizachew Assefa
    Univ Adelaide, Adelaide, SA, Australia.;Univ Gondar, Gondar, Ethiopia..
    Thakur, J. S.
    Post Grad Inst Med Educ & Res, Sch Publ Hlth, Chandigarh, India..
    Thomson, Alan J.
    Adapt Knowledge Management, Victoria, BC, Canada..
    Thorne-Lyman, Andrew L.
    Harvard Univ, Dept Nutr, Boston, MA 02115 USA.;WorldFish, George Town, Malaysia..
    Thrift, Amanda G.
    Monash Univ, Dept Med, Sch Clin Sci Monash Hlth, Melbourne, Vic, Australia..
    Thurston, George D.
    New York Univ, Nelson Inst Environm Med, Sch Med, Tuxedo Pk, NY USA..
    Tobe-Gai, Ruoyan
    Natl Ctr Child Hlth & Dev, Tokyo, Japan..
    Tonelli, Marcello
    Univ Calgary, Calgary, AB, Canada..
    Topor-Madry, Roman
    Jagiellonian Univ Med Coll, Inst Publ Hlth, Fac Hlth Sci, Krakow, Poland.;Wroclaw Med Univ, Fac Hlth Sci, Wroclaw, Poland..
    Topouzis, Fotis
    Aristotle Univ Thessaloniki, Thessaloniki, Greece..
    Tran, Bach Xuan
    Johns Hopkins Univ, Baltimore, MD USA.;Hanoi Med Univ, Hanoi, Vietnam..
    Dimbuene, Zacharie Tsala
    Univ Kinshasa, Fac Econ & Management, Dept Populat Sci & Dev, Kinshasa, Congo.;African Populat & Hlth Res Ctr, Nairobi, Kenya..
    Tsilimbaris, Miltiadis
    Univ Crete, Dept Med, Iraklion, Greece..
    Tura, Abera Kenay
    Haramaya Univ, Dire Dawa, Ethiopia.;Univ Groningen, Groningen, Netherlands..
    Tuzcu, Emin Murat
    Cleveland Clin, Cleveland, OH USA..
    Tyrovolas, Stefanos
    Univ Barcelona, Parc Sanitari Sant Joan Deu, Fundacio Sant Joan Deu, CIBERSAM, Barcelona, Spain..
    Ukwaja, Kingsley N.
    Fed Teaching Hosp, Dept Internal Med, Abakaliki, Nigeria..
    Undurraga, Eduardo A.
    Brandeis Univ, Waltham, MA USA..
    Uneke, Chigozie Jesse
    Ebonyi State Univ, Abakaliki, Nigeria..
    Uthman, Olalekan A.
    Univ Warwick, Warwick Med Sch, Coventry, W Midlands, England..
    van Gool, Coen H.
    Natl Inst Publ Hlth & Environm, Bilthoven, Netherlands..
    van Os, Jim
    Maastricht Univ Med Ctr, Maastricht, Netherlands..
    Vasankari, Tommi
    UKK Inst Hlth Promot Res, Tampere, Finland..
    Vasconcelos, Ana Maria Nogales
    Univ Brasilia, Brasilia, DF, Brazil..
    Venketasubramanian, Narayanaswamy
    Raffles Hosp, Raffles Neurosci Ctr, Singapore, Singapore..
    Violante, Francesco S.
    Univ Bologna, Bologna, Italy..
    Vlassov, Vasiliy Victorovich
    Natl Res Univ Higher Sch Econ, Moscow, Russia..
    Vollset, Stein Emil
    Inst Hlth Metr & Evaluat, Seattle, WA USA.;Univ Bergen, Dept Global Publ Hlth & Primary Care, Bergen, Norway.;Ctr Dis Burden, Oslo, Norway..
    Wagner, Gregory R.
    Harvard Univ, Harvard T H Chan Sch Publ Hlth, Boston, MA 02115 USA..
    Wallin, Mitchell T.
    VA Med Ctr, Washington, DC USA.;Georgetown Univ, Dept Neurol, Washington, DC USA..
    Wang, Linhong
    Natl Ctr Chron & Noncommunicable Dis Control & Pr, Beijing, Peoples R China..
    Weichenthal, Scott
    McGill Univ, Montreal, PQ, Canada..
    Weiderpass, Elisabete
    Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.;Canc Registry Norway, Inst Populat Based Canc Res, Dept Res, Oslo, Norway.;Univ Tromso, Arct Univ Norway, Dept Community Med, Fac Hlth Sci, Tromso, Norway.;Genet Epidemiol Grp, Folkhalsan Res Ctr, Helsinki, Finland..
    Weintraub, Robert G.
    Murdoch Childrens Res Inst, Melbourne, Vic, Australia.;Royal Childrens Hosp, Melbourne, Vic, Australia..
    Werdecker, Andrea
    Competence Ctr Mortal Follow Up German Natl Cohor, Wiesbaden, Germany..
    WestermaM, Ronny
    Fed Inst Populat Res, Wiesbaden, Germany.;German Natl Cohort Consortium, Heidelberg, Germany..
    Wijeratne, Tissa
    Univ Melbourne, Melbourne, Vic, Australia.;Western Hlth, Footscray, Vic, Australia..
    Wilkinson, James D.
    Wayne State Univ, Sch Med, Detroit, MI USA.;Childrens Hosp Michigan, Detroit, MI USA..
    Williams, Hywel C.
    Univ Nottingham, Ctr Evidence based Dermatol, Nottingham, England..
    Wiysonge, Charles Shey
    South African Med Res Council, Cape Town, South Africa.;Univ Stellenbosch, Cape Town, South Africa..
    Woldeyohannes, Solomon Meseret
    Univ Gondar, Inst Publ Hlth, Dept Epidemiol & Biostat, Gondar, Ethiopia..
    Wolfe, Charles D. A.
    Kings Coll London, Div Hlth & Social Care Res, London, England.;Guys St Thomas NHS Fdn Trust & Kings Coll London, Natl Inst Hlth Res Comprehens Biomed Res Ctr, London, England..
    Won, Sungho
    Seoul Natl Univ, Grad Sch Publ Hlth, Seoul, South Korea..
    Xu, Gelin
    Nanjing Univ, Jinling Hosp, Dept Neurol, Sch Med, Nanjing, Peoples R China..
    Yadav, Ajit Kumar
    Int Inst Populat Sci, Mumbai, Maharashtra, India..
    Yakob, Bereket
    Univ KwaZulu Natal, Sch Nursing & Publ Hlth, Discipline Publ Hlth Med, Durban, South Africa..
    Yan, Lijing L.
    Duke Kunshan Univ, Global Hlth Res Ctr, Kunshan, Peoples R China..
    Yan, Yuichiro
    Northwestern Univ, Dept Prevent Med, Chicago, IL USA..
    Yaseri, Mehdi
    Univ Tehran Med Sci, Tehran, Iran..
    Ye, Pengpeng
    Yip, Paul
    Univ Hong Kong, Social Work & Social Adm Dept, Hong Kong, Peoples R China.;Univ Hong Kong, Hong Kong Jockey Club Ctr Suicide Res & Prevent, Hong Kong, Peoples R China..
    Yonemoto, Naohiro
    Kyoto Univ, Sch Publ Hlth, Dept Biostat, Kyoto, Japan..
    Yoon, Seok-Jun
    Korea Univ, Dept Prevent Med, Coll Med, Seoul, South Korea..
    Younis, Mustafa Z.
    Jackson State Univ, Jackson, MS USA..
    Yu, Chuanhua
    Wuhan Univ, Dept Epidemiol & Biostat, Sch Publ Hlth, Wuhan, Peoples R China.;Wuhan Univ, Global Hlth Inst, Wuhan, Peoples R China..
    Zaidi, Zoubida
    Univ Hosp, Setif, Algeria..
    Zaki, Maysaa El Sayed
    Mansoura Univ, Fac Med, Mansoura, Egypt..
    Zeeb, Hajo
    Leibniz Inst Prevent Res & Epidemiol, Bremen, Germany..
    Zodpey, Sanjay
    Publ Hlth Fdn India, Gurgaon, India.;Publ Hlth Fdn India, Gurgaon, India..
    Zonies, David
    Oregon Hlth & Sci Univ, Portland, OR 97201 USA..
    Zuhlke, Liesl Joanna
    Red Cross War Mem Childrens Hosp, Cape Town, South Africa..
    Vos, Theo
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Lopez, Alan D.
    Inst Hlth Metr & Evaluat, Seattle, WA USA.;Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia..
    Murray, Christopher J. L.
    Inst Hlth Metr & Evaluat, Seattle, WA USA..
    Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990-2015: a systematic analysis for the Global Burden of Disease Study 20152016In: The Lancet, ISSN 0140-6736, E-ISSN 1474-547X, Vol. 388, no 10053, p. 1603-1658Article in journal (Refereed)
    Abstract [en]

    Background Healthy life expectancy (HALE) and disability-adjusted life-years (DALYs) provide summary measures of health across geographies and time that can inform assessments of epidemiological patterns and health system performance, help to prioritise investments in research and development, and monitor progress toward the Sustainable Development Goals (SDGs). We aimed to provide updated HALE and DALYs for geographies worldwide and evaluate how disease burden changes with development. Methods We used results from the Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 2015) for all-cause mortality, cause-specific mortality, and non-fatal disease burden to derive HALE and DALYs by sex for 195 countries and territories from 1990 to 2015. We calculated DALYs by summing years of life lost (YLLs) and years of life lived with disability (YLDs) for each geography, age group, sex, and year. We estimated HALE using the Sullivan method, which draws from age-specific death rates and YLDs per capita. We then assessed how observed levels of DALYs and HALE differed from expected trends calculated with the Socio-demographic Index (SDI), a composite indicator constructed from measures of income per capita, average years of schooling, and total fertility rate. Findings Total global DALYs remained largely unchanged from 1990 to 2015, with decreases in communicable, neonatal, maternal, and nutritional (Group 1) disease DALYs off set by increased DALYs due to non-communicable diseases (NCDs). Much of this epidemiological transition was caused by changes in population growth and ageing, but it was accelerated by widespread improvements in SDI that also correlated strongly with the increasing importance of NCDs. Both total DALYs and age-standardised DALY rates due to most Group 1 causes significantly decreased by 2015, and although total burden climbed for the majority of NCDs, age-standardised DALY rates due to NCDs declined. Nonetheless, age-standardised DALY rates due to several high-burden NCDs (including osteoarthritis, drug use disorders, depression, diabetes, congenital birth defects, and skin, oral, and sense organ diseases) either increased or remained unchanged, leading to increases in their relative ranking in many geographies. From 2005 to 2015, HALE at birth increased by an average of 2.9 years (95% uncertainty interval 2.9-3.0) for men and 3.5 years (3.4-3.7) for women, while HALE at age 65 years improved by 0.85 years (0.78-0.92) and 1.2 years (1.1-1.3), respectively. Rising SDI was associated with consistently higher HALE and a somewhat smaller proportion of life spent with functional health loss; however, rising SDI was related to increases in total disability. Many countries and territories in central America and eastern sub-Saharan Africa had increasingly lower rates of disease burden than expected given their SDI. At the same time, a subset of geographies recorded a growing gap between observed and expected levels of DALYs, a trend driven mainly by rising burden due to war, interpersonal violence, and various NCDs. Interpretation Health is improving globally, but this means more populations are spending more time with functional health loss, an absolute expansion of morbidity. The proportion of life spent in ill health decreases somewhat with increasing SDI, a relative compression of morbidity, which supports continued efforts to elevate personal income, improve education, and limit fertility. Our analysis of DALYs and HALE and their relationship to SDI represents a robust framework on which to benchmark geography-specific health performance and SDG progress. Country-specific drivers of disease burden, particularly for causes with higher-than-expected DALYs, should inform financial and research investments, prevention efforts, health policies, and health system improvement initiatives for all countries along the development continuum.

  • 179.
    Kassebaum, Nicholas J.
    et al.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Barber, Ryan M.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Bhutta, Zulfiqar A.
    Aga Khan Univ, Ctr Excellence Women & Child Hlth, Karachi, Pakistan.;Hosp Sick Children, Ctr Global Child Hlth, Toronto, ON, Canada..
    Dandona, Lalit
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA.;Publ Hlth Fdn India, New Delhi, India..
    Gething, Peter W.
    Univ Oxford, Dept Zool, Oxford, England..
    Hay, Simon I.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Kinfu, Yohannes
    Univ Canberra, Fac Hlth, Ctr Res & Act Publ Hlth, Canberra, ACT, Australia..
    Larson, Heidi J.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA.;London Sch Hyg & Trop Med, Dept Infect Dis Epidemiol, London, England..
    Liang, Xiaofeng
    Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China..
    Lim, Stephen S.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Lopez, Alan D.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA.;Univ Melbourne, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia..
    Lozano, Rafael
    Mensah, George A.
    Mokdad, Ali H.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Naghavi, Mohsen
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Pinho, Christine
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Salomon, Joshua A.
    Steiner, Caitlyn
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Vos, Theo
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Wang, Haidong
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Abajobir, Amanuel Alemu
    Abate, Kalkidan Hassen
    Abbas, Kaja M.
    Abd-Allah, Foad
    Abdallat, Mahmud A.
    Abdulle, Abdishakur M.
    Abera, Semaw Ferede
    Aboyans, Victor
    Abubakar, Ibrahim
    Abu-Rmeileh, Niveen M. E.
    Achoki, Tom
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Adebiyi, Akindele Olupelumi
    Univ Ibadan, Coll Med, Ibadan, Nigeria.;Univ Coll Hosp, Ibadan, Nigeria..
    Adedeji, Isaac Akinkunmi
    Olabisi Onabanjo Univ, Ago Iwoye, Nigeria..
    Adelekan, Ademola Lukman
    Univ Ibadan, Ibadan, Nigeria.;Publ Hlth Promot Alliance, Osogbo, Nigeria..
    Adou, Arsene Kouablan
    Assoc Ivoirienne Bien Etre Familial, Abidjan, Cote Ivoire..
    Afanvi, Kossivi Agbelenko
    Direct Dist Sanitaire Haho, Notse, Togo.;Univ Lome, Fac Sci Sante, Lome, Togo..
    Agarwal, Arnav
    Univ Toronto, Toronto, ON, Canada.;McMaster Univ, Hamilton, ON, Canada..
    Kiadaliri, Aliasghar Ahmad
    Lund Univ, Clin Epidemiol Unit, Orthoped, Dept Clin Sci Lund, Lund, Sweden.;Kerman Univ Med Sci, Inst Futures Studies Hlth, Hlth Serv Management Res Ctr, Kerman, Iran..
    Ajala, Oluremi N.
    Univ Pittsburgh, Med Ctr, Mckeesport, PA USA..
    Akinyemiju, Tomi F.
    Univ Alabama Birmingham, Dept Epidemiol, Birmingham, AL USA. Univ Alabama Birmingham, Birmingham, AL USA..
    Akseer, Nadia
    Hosp Sick Children, Ctr Global Child Hlth, Toronto, ON, Canada.;Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada..
    Al-Aly, Ziyad
    Washington Univ, St Louis, MO USA..
    Alam, Khurshid
    Univ Melbourne, Childrens Res Inst, Melbourne, Vic, Australia.;Univ Melbourne, Melbourne, Vic, Australia.;Univ Sydney, Sydney, NSW, Australia..
    Alam, Noore K. M.
    Queensland Hlth, Herston, Qld, Australia..
    Alasfoor, Deena
    Minist Hlth, Al Khuwair, Oman..
    Aldhahri, Saleh Fahed
    King Saud Univ, Riyadh, Saudi Arabia. King Fahad Med City, Dept Anesthesiol, Riyadh, Saudi Arabia.;King Fahad Med City, Riyadh, Saudi Arabia..
    Aldridge, Robert William
    Alhabib, Samia
    King Abdullah Bin Abdulaziz Univ Hosp, Riyadh, Saudi Arabia..
    Ali, Raghib
    Univ Oxford, Oxford, England..
    Alkerwi, Ala'a
    Luxembourg Inst Hlth, Strassen, Luxembourg..
    Alla, Francois
    Univ Lorraine, Sch Publ Hlth, Nancy, France..
    Al-Raddadi, Rajaa
    Minist Hlth, Jeddah, Saudi Arabia..
    Alsharif, Ubai
    Charite, Berlin, Germany..
    Martin, Elena Alvarez
    Minist Hlth Social Policy & Equal, Govt Delegat Natl Plan Drugs, Spanish Observ Drugs, Madrid, Spain..
    Alvis-Guzman, Nelson
    Univ Cartagena, Cartagena De Indias, Colombia..
    Amare, Azmeraw T.
    Univ Adelaide, Sch Med, Adelaide, SA, Australia.;Bahir Dar Univ, Coll Med & Hlth Sci, Bahir Dar, Ethiopia. Bahir Dar Univ, Bahir Dar, Ethiopia..
    Amberbir, Alemayehu
    Dignitas Int, Zomba, Malawi..
    Amegah, Adeladza Kofi
    Univ Cape Coast, Cape Coast, Ghana..
    Ammar, Walid
    Minist Publ Hlth, Beirut, Lebanon..
    Amrock, Stephen Marc
    Oregon Hlth & Sci Univ, Portland, OR 97201 USA..
    Andersen, Hjalte H.
    Aalborg Univ, Fac Med, Dept Hlth Sci & Technol, Ctr Sensory Motor Interact, Aalborg, Denmark..
    Anderson, Gregory M.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Antoine, Rose Mayerline
    Rose Fdn Haiti, Portau Au Prince, Haiti..
    Antonio, Carl Abelardo T.
    Univ Philippines, Coll Publ Hlth, Dept Hlth Policy & Adm, Manila, Philippines..
    Aregay, Atsede Fantahun
    Ärnlöv, Johan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology. Dalarna Univ, Falun, Sweden..
    Arora, Megha
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Arsenijevic, Valentina S. Arsic
    Univ Belgrade, Sch Med, Inst Microbiol & Immunol, Belgrade, Serbia.;Univ Childrens Hosp, Belgrade, Serbia..
    Artaman, Al
    Asayesh, Hamid
    Qom Univ Med Sci, Sch Paramed, Dept Emergency Med, Qom, Iran..
    Atique, Suleman
    Taipei Med Univ, Grad Inst Biomed Informat, Taipei, Taiwan..
    Avokpaho, Euripide Frinel G. Arthur
    Inst Rech Clin Benin, Cotonou, Benin.;LERAS Afrique, Parakou, Benin..
    Awasthi, Ashish
    Sanjay Gandhi Postgraduate Inst Med Sci, Lucknow, Uttar Pradesh, India..
    Quintanilla, Beatriz Paulina Ayala
    La Trobe Univ, Judith Lumley Ctr Mother Infant & Family Hlth Res, Melbourne, Vic, Australia.;Peruvian Natl Inst Hlth, Lima, Peru..
    Azzopardi, Peter
    Univ Melbourne, Dept Paediat, Melbourne, Vic, Australia.;Univ Melbourne, Childrens Res Inst, Melbourne, Vic, Australia.;South Australian Hlth & Med Res Inst, Wardliparingga Aboriginal Res Unit, Adelaide, SA, Australia..
    Bacha, Umar
    Univ Management & Technol, Sch Hlth Sci, Lahore, Pakistan..
    Badawi, Alaa
    Univ Toronto, Fac Med, Dept Nutr Sci, Toronto, ON, Canada.;Publ Hlth Agcy Canada, Toronto, ON, Canada..
    Bahit, Maria C.
    INECO Neurociencias, Rosario, Santa Fe, Argentina..
    Balakrishnan, Kalpana
    Sri Ramachandra Univ, Chennai, Tamil Nadu, India..
    Banerjee, Amitava
    Barac, Aleksandra
    Univ Belgrade, Fac Med, Belgrade, Serbia..
    Barker-Collo, Suzanne L.
    Univ Auckland, Sch Psychol, Auckland, New Zealand..
    Barnighausen, Till
    Africa Hlth Res Inst, Mtubatuba, South Africa.;Heidelberg Univ, Inst Publ Hlth, Heidelberg, Germany..
    Basu, Sanjay
    Stanford Univ, Stanford, CA 94305 USA..
    Bayou, Tigist Assefa
    Bayou, Yibeltal Tebekaw
    Jhpiego Ethiopia, Addis Ababa, Ethiopia..
    Bazargan-Hejazi, Shahrzad
    Charles R Drew Univ Med & Sci, 1621 E 120th St, Los Angeles, CA 90059 USA.;Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA.;Kermanshah Univ Med Sci, Kermanshah, Iran..
    Beardsley, Justin
    Univ Oxford, Ho Chi Minh City, Vietnam..
    Bedi, NeerajHaidong Wang
    Coll Publ Hlth & Trop Med, Jazan, Saudi Arabia..
    Bekele, Tolesa
    Madawalabu Univ, Bale Goba, Ethiopia..
    Bell, Michelle L.
    Yale Univ, New Haven, CT USA..
    Bennett, Derrick A.
    Univ Oxford, Oxford, England..
    Bensenor, Isabela M.
    Berhane, Adugnaw
    Debre Berhane Univ, Debre Berhan, Ethiopia..
    Bernabe, Eduardo
    Betsu, Balem Demtsu
    Beyene, Addisu Shunu
    Haramaya Univ, Harar, Ethiopia..
    Biadgilign, Sibhatu
    Bikbov, Boris
    Academician VI Shumakov Fed Res Ctr Transplantol, Dept Nephrol Issues Transplanted Kidney, Moscow, Russia..
    Bin Abdulhak, Aref A.
    Univ Iowa Hosp & Clin, Iowa City, IA 52242 USA..
    Biroscak, Brian J.
    Yale Univ, New Haven, CT USA.;Univ S Florida, Tampa, FL USA..
    Biryukov, Stan
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Bisanzio, Donal
    Univ Oxford, Nuffield Dept Med, Oxford, England..
    Bjertness, Espen
    Blore, Jed D.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Brainin, Michael
    Danube Univ Krems, Krems, Austria..
    Brazinova, Alexandra
    Breitborde, Nicholas J. K.
    Brugha, Traolach S.
    Butt, Zahid A.
    Campos-Nonato, Ismael Ricardo
    Campuzano, Julio Cesar
    Cardenas, Rosario
    Carrero, Juan Jesus
    Carter, Austin
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Casey, Daniel C.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Castaneda-Oquela, Carlos A.
    Castro, Ruben Estanislao
    Catala-Lopez, Ferran
    Cavalleri, Fiorella
    Chang, Hsing-Yi
    Chang, Jung -Chen
    Chavan, Laxmikant
    Chibueze, Chioma Ezinne
    Chisumpa, Vesper Hichilombwe
    Choi, Jee-Young Jasmine
    Chowdhury, Rajiv
    Christopher, Devasahayam Jesudas
    Ciobanu, Liliana G.
    Univ Adelaide, Adelaide, SA, Australia..
    Cirillo, Massimo
    Coates, Matthew M.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Coggeshall, Megan
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Colistro, Valentina
    Colquhoun, Samantha M.
    Univ Melbourne, Childrens Res Inst, Melbourne, Vic, Australia.;Univ Melbourne, Melbourne, Vic, Australia..
    Cooper, Cyrus
    Univ Oxford, NIHR Musculoskeletal Biomed Res Ctr, Oxford, England..
    Cooper, Leslie Trumbull
    Cortinovis, Monica
    Dahiru, Tukur
    Damasceno, Albertino
    Danawi, Hadi
    Dandona, Rakhi
    Publ Hlth Fdn India, New Delhi, India..
    Das Neves, Jose
    De Leo, Diego
    Dellavalle, Robert P.
    Deribe, Kebede
    Deribew, Amare
    Univ Oxford, Nuffield Dept Med, Oxford, England..
    Jarlais, Don C. Des
    Dharmaratne, Samath D.
    Dicker, Daniel J.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Ding, Eric L.
    Dossou, Edem
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Dubey, Manisha
    Ebel, Beth E.
    Univ Washington, Harborview Injury Prevent & Res Ctr, Seattle, WA USA..
    Ellingsen, Christian Lycke
    Elyazar, Iqbal
    Endries, Aman Yesuf
    Ermakov, Sergey Petrovich
    Eshrati, Babak
    Esteghamati, Alireza
    Faraon, Emerito Jose Aquino
    Univ Philippines, Coll Publ Hlth, Manila, Philippines.;Dept Hlth, Manila, Philippines..
    Farid, Talha A.
    Farinha, Carla Sofia E. Sa
    Faro, Andre
    Farvid, Maryam S.
    Farzadfar, Farshad
    Fereshtehnejad, Seyed-Mohammad
    Fernandes, Joao C.
    Fischer, Florian
    Univ Bielefeld, Bielefeld, Germany. Acad Med Sci, Inst Gerontol, Kiev, Ukraine..
    Fitchett, Joseph R. A.
    Fleming, Tom
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Gt, Nataliya Fo
    Franca, Elisabeth Barboza
    Univ Fed Minas Gerais, Belo Horizonte, MG, Brazil..
    Franklin, Richard C.
    James Cook Univ, Townsville, Qld, Australia..
    Fraser, Maya S.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Friedman, Joseph
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Pullman, Nancy
    Furst, Thomas
    Univ Basel, Basel, Switzerland..
    Futran, Neal D.
    Univ Washington, Seattle, WA USA..
    Gambashidze, Ketevan
    Natl Ctr Dis Control & Publ Hlth, Tbilisi, Rep of Georgia..
    Gamkrelidze, Amiran
    Gebre, Teshome
    Task Force Global Hlth, Decatur, GA USA..
    Gebrehiwot, Tsegaye Tewelde
    Gebremedhin, Amanuel Tesfay
    Ludwig Maximilians Univ Munchen, Munich, Germany..
    Gebremedhin, Mengistu
    Gebru, Alemseged Aregay
    Kilte Awlaelo Hlth & Demog Surveillance Syst, Mekelle, Ethiopia..
    Geleijnse, Johanna M.
    Wageningen Univ, Div Human Nutr, Wageningen, Netherlands..
    Gibney, Katherine B.
    Univ Melbourne, Peter Doherty Inst Infect & Immun, Melbourne, Vic, Australia.;Royal Melbourne Hosp, Melbourne, Vic, Australia..
    Giref, Ababi Zergaw
    Giroud, Maurice
    Univ Hosp Dijon, Dijon, France..
    Gishu, Melkamu Dedefo
    Glaser, Elizabeth
    Goenka, Shifalika
    Publ Hlth Fdn India, New Delhi, India..
    Gomez-Dantes, Hector
    Gona, Philimon
    Goodridge, Amador
    Gopalani, Sameer Vali
    Goto, Atsushi
    Graetz, Nicholas
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Gugnani, Harish Chander
    Guo, Yuming
    Gupta, Rahul
    Gupta, Rajeev
    Gupta, Vipin
    Hafezi-Nejad, Nima
    Hailu, Alemayehu Desalegne
    Hailu, Gessessew Bugssa
    Kilte Awlaelo Hlth & Demog Surveillance Syst, Mekelle, Ethiopia..
    Hamadeh, Randah Ribhi
    Hamidi, Samer
    Hancock, Jamie
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Handal, Alexis J.
    Hankey, Graeme J.
    Harb, Hilda L.
    Minist Publ Hlth, Beirut, Lebanon..
    Harikrishnan, Sivadasanpillai
    Harun, Kimani M.
    Univ Washington, Seattle, WA USA..
    Havmoeller, Rasmus
    Hoek, Hans W.
    Horino, Masako
    Horita, Nobuyuki
    Hosgood, H. Dean
    Hoy, Damian G.
    Htet, Aung Soe
    Hu, Guoqing
    Huang, Hsiang
    Huang, John J.
    Yale Univ, New Haven, CT USA..
    Huybrechts, Inge
    Huynh, Chantal
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Iannarone, Marissa
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Iburg, Kim Moesgaard
    Idrisov, Bulat T.
    Iyer, Veena J.
    Jacobsen, Kathryn H.
    Jahanmehr, Nader
    Jakovljevic, Mihajlo B.
    Javanbakht, Mehdi
    Jayatilleke, Achala Upendra
    Jee, Sun Ha
    Jeemon, Panniyammakal
    Publ Hlth Fdn India, Ctr Control Chron Condit, New Delhi, India..
    Jha, Vivekanand
    Univ Oxford, Oxford, England..
    Jiang, Guohong
    Jiang, Ying
    Jibat, Tariku
    Wageningen Univ, Wageningen, Netherlands..
    Jonas, Jost B.
    Kabir, Zubair
    Kamal, Ritul
    Kan, Haidong
    Karch, Andre
    Karletsos, Dimitris
    Kasaeian, Amir
    Kaul, Anil
    Kawakami, Norito
    Kayibanda, Jeanne Francoise
    Kazanjan, Konstantin
    Natl Ctr Dis Control & Publ Hlth, Tbilisi, Rep of Georgia..
    Kazi, Dhruv S.
    Keiyoro, Peter Njenga
    Kemmer, Laura
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Kemp, Andrew Haddon
    Univ Sydney, Sydney, NSW, Australia..
    Kengne, Andre Pascal
    Keren, Andre
    Kereselidze, Maia
    Natl Ctr Dis Control & Publ Hlth, Tbilisi, Rep of Georgia..
    Kesavachandran, Chandrasekharan Nair
    Khader, Yousef Saleh
    Khan, Abdur Rahman
    Khan, Ejaz Ahmad
    Khang, Young-Ho
    Khonelidze, Irma
    Natl Ctr Dis Control & Publ Hlth, Tbilisi, Rep of Georgia..
    Khosravi, Ardeshir
    Khubchandani, Jagdish
    Kim, Yun Jin
    Kivipelto, Miia
    Knibbs, Luke D.
    Kokubo, Yoshihiro
    Kosen, Soewarta
    Koul, Parvaiz A.
    Koyanagi, Ai
    Krishnaswami, Sanjay
    Defo, Barthelemy Kuate
    Bicer, Burcu Kucuk
    Kudom, Andreas A.
    Univ Cape Coast, Cape Coast, Ghana..
    Kulikoff, Xie Rachel
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Kulkarni, Chanda
    Kumar, G. Anil
    Publ Hlth Fdn India, New Delhi, India..
    Kutz, Michael J.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Lal, Dharmesh Kumar
    Lalloo, Ratilal
    Lam, Hilton
    Lamadrid-Figueroa, Hector
    Lan, Qing
    Larsson, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
    Laryea, Dennis Odai
    Leigh, James
    Univ Sydney, Sydney, NSW, Australia..
    Leung, Ricky
    Li, Yichong
    Li, Yongmei
    Lipshultz, Steven E.
    Liu, Patrick Y.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Liu, Shiwei
    Chinese Ctr Dis Control & Prevent, Natl Ctr Chron & Noncommun Dis Control & Prevent, Beijing, Peoples R China..
    Liu, Yang
    Chinese Ctr Dis Control & Prevent, Natl Ctr Chron & Noncommun Dis Control & Prevent, Beijing, Peoples R China..
    Lloyd, Belinda K.
    Lotufo, Paulo A.
    Lunevicius, Raimundas
    Ma, Stefan
    El Razek, Hassan Magdy Abd
    El Razek, Mohammed Magdy Abd
    Majdan, Marek
    Majeed, Azeem
    Malekzadeh, Reza
    Mapoma, Chabila C.
    Marcenes, Wagner
    Margolis, David Joel
    Marquez, Neal
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Masiye, Felix
    Marzan, Melvin Barrientos
    Mason-Jones, Amanda J.
    Mazorodze, Tasara T.
    Meaney, Peter A.
    Mehari, Alem
    Mehndiratta, Man Mohan
    Mena-Rodriguez, Fabiola
    Mekonnen, Alemayehu B.
    Univ Sydney, Sydney, NSW, Australia..
    Melaku, Yohannes Adama
    Univ Adelaide, Sch Med, Adelaide, SA, Australia..
    Memish, Ziad A.
    Mendoza, Walter
    Meretoja, Atte
    Univ Melbourne, Dept Med, Melbourne, Vic, Australia. Univ Melbourne, Inst Hlth & Ageing, Melbourne, Vic, Australia..
    Meretoja, Tuomo J.
    Mhimbira, Francis Apolinary
    Miller, Ted R.
    Mills, Edward J.
    Mirarefin, Mojde
    Misganaw, Awoke
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Ibrahim, Norlinah Mohamed
    Mohammad, Karzan Abdulmuhsin
    Mohammadi, Alireza
    Mohammed, Shafiu
    Heidelberg Univ, Inst Publ Hlth, Heidelberg, Germany..
    Mola, Glen Liddell D.
    Monasta, Lorenzo
    Monis, Jonathan De la Cruz
    Hernandez, Julio Cesar Montanez
    Montero, Pablo
    Montico, Marcella
    Mooney, Meghan D.
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Moore, Ami R.
    Moradi-Lakeh, Maziar
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Morawska, Lidia
    Mori, Rintaro
    Mueller, Ulrich
    Murthy, Gudlavalleti Venkata Satyanarayana
    London Sch Hyg & Trop Med, London, England..
    Murthy, Srinivas
    Nachega, Jean B.
    Naheed, Aliya
    Naldi, Luigi
    Nand, Devina
    Nangia, Vinay
    Nash, Denis
    Neupane, Subas
    Newton, John N.
    Ng, Marie
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Ngalesoni, Frida Namnyak
    Nguhiu, Peter
    Nguyen, Grant
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Le Nguyen, Quyen
    Nisar, Muhammad Imran
    Aga Khan Univ, Karachi, Pakistan..
    Nomura, Marika
    Norheim, Ole F.
    Norman, Rosana E.
    Nyakarahuka, Luke
    Obermeyer, Carla Makhlouf
    Ogbo, Felix Akpojene
    Oh, In-Hwan
    Ojelabi, Foluke Adetola
    Univ Ibadan, Ibadan, Nigeria..
    Olivares, Pedro R.
    Olusanya, Bolajoko Olubukunola
    Olusanya, Jacob Olusegun
    Opio, John Nelson
    Oren, Eyal
    Ota, Erika
    Oyekale, Abayomi Samuel
    Pa, Mahesh
    Pain, Amanda
    Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA..
    Papantoniou, Nikolaos
    Park, Eun-Kee
    Park, Hye-Youn
    Caicedo, Angel J. Paternina
    Patten, Scott B.
    Paul, Vinod K.
    Pereira, David M.
    Perico, Norberto
    Pesudovs, Konrad
    Petzold, Max
    Phillips, Michael Robert
    Pillay, Julian David
    Pishgar, Farhad
    Polinder, Suzanne
    Pope, Daniel
    Pourmalek, Farshad
    Qorbani, Mostafa
    Rafay, Anwar
    Rahimi, Kazem
    Univ Oxford, Oxford, England..
    Rahimi-Movaghar, Vafa
    Rahman, Mahfuzar
    Rahman, Mohammad Hifz Ur
    Rahman, Sajjad Ur
    Rai, Rajesh Kumar
    Ram, Usha
    Ranabhat, Chhabi Lal
    Rangaswamy, Thara
    Rao, Paturi Vishnupriya
    Refaat, Amany H.
    Remuzzi, Giuseppe
    Global, regional, and national levels of maternal mortality, 1990-2015: a systematic analysis for the Global Burden of Disease Study 20152016In: The Lancet, ISSN 0140-6736, E-ISSN 1474-547X, Vol. 388, no 10053, p. 1775-1812Article in journal (Refereed)
    Abstract [en]

    Background In transitioning from the Millennium Development Goal to the Sustainable Development Goal era, it is imperative to comprehensively assess progress toward reducing maternal mortality to identify areas of success, remaining challenges, and frame policy discussions. We aimed to quantify maternal mortality throughout the world by underlying cause and age from 1990 to 2015. Methods We estimated maternal mortality at the global, regional, and national levels from 1990 to 2015 for ages 10-54 years by systematically compiling and processing all available data sources from 186 of 195 countries and territories, 11 of which were analysed at the subnational level. We quantified eight underlying causes of maternal death and four timing categories, improving estimation methods since GBD 2013 for adult all-cause mortality, HIV-related maternal mortality, and late maternal death. Secondary analyses then allowed systematic examination of drivers of trends, including the relation between maternal mortality and coverage of specific reproductive health-care services as well as assessment of observed versus expected maternal mortality as a function of Socio-demographic Index (SDI), a summary indicator derived from measures of income per capita, educational attainment, and fertility. Findings Only ten countries achieved MDG 5, but 122 of 195 countries have already met SDG 3.1. Geographical disparities widened between 1990 and 2015 and, in 2015, 24 countries still had a maternal mortality ratio greater than 400. The proportion of all maternal deaths occurring in the bottom two SDI quintiles, where haemorrhage is the dominant cause of maternal death, increased from roughly 68% in 1990 to more than 80% in 2015. The middle SDI quintile improved the most from 1990 to 2015, but also has the most complicated causal profile. Maternal mortality in the highest SDI quintile is mostly due to other direct maternal disorders, indirect maternal disorders, and abortion, ectopic pregnancy, and/or miscarriage. Historical patterns suggest achievement of SDG 3.1 will require 91% coverage of one antenatal care visit, 78% of four antenatal care visits, 81% of in-facility delivery, and 87% of skilled birth attendance. Interpretation Several challenges to improving reproductive health lie ahead in the SDG era. Countries should establish or renew systems for collection and timely dissemination of health data; expand coverage and improve quality of family planning services, including access to contraception and safe abortion to address high adolescent fertility; invest in improving health system capacity, including coverage of routine reproductive health care and of more advanced obstetric care-including EmOC; adapt health systems and data collection systems to monitor and reverse the increase in indirect, other direct, and late maternal deaths, especially in high SDI locations; and examine their own performance with respect to their SDI level, using that information to formulate strategies to improve performance and ensure optimum reproductive health of their population.

  • 180. Kassebaum, Nicholas J
    et al.
    Bertozzi-Villa, Amelia
    Coggeshall, Megan S
    Shackelford, Katya A
    Steiner, Caitlyn
    Heuton, Kyle R
    Gonzalez-Medina, Diego
    Barber, Ryan
    Huynh, Chantal
    Dicker, Daniel
    Templin, Tara
    Wolock, Timothy M
    Ozgoren, Ayse Abbasoglu
    Abd-Allah, Foad
    Abera, Semaw Ferede
    Achoki, Tom
    Adelekan, Ademola
    Ademi, Zanfina
    Adou, Arsène Kouablan
    Adsuar, José C
    Agardh, Emilie E
    Akena, Dickens
    Alasfoor, Deena
    Alemu, Zewdie Aderaw
    Alfonso-Cristancho, Rafael
    Alhabib, Samia
    Ali, Raghib
    Al Kahbouri, Mazin J
    Alla, François
    Allen, Peter J
    Almazroa, Mohammad A
    Alsharif, Ubai
    Alvarez, Elena
    Alvis-Guzmán, Nelson
    Amankwaa, Adansi A
    Amare, Azmeraw T
    Amini, Hassan
    Ammar, Walid
    Antonio, Carl A T
    Anwari, Palwasha
    Ärnlöv, Johan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology.
    Arsenijevic, Valentina S Arsic
    Artaman, Ali
    Asad, Majed Masoud
    Asghar, Rana J
    Assadi, Reza
    Atkins, Lydia S
    Badawi, Alaa
    Balakrishnan, Kalpana
    Basu, Arindam
    Basu, Sanjay
    Beardsley, Justin
    Bedi, Neeraj
    Bekele, Tolesa
    Bell, Michelle L
    Bernabe, Eduardo
    Beyene, Tariku J
    Bhutta, Zulfiqar
    Bin Abdulhak, Aref
    Blore, Jed
    Basara, Berrak Bora
    Bose, Dipan
    Breitborde, Nicholas
    Cárdenas, Rosario
    Castañeda-Orjuela, Carlos A
    Castro, Ruben Estanislao
    Catalá-López, Ferrán
    Cavlin, Alanur
    Chang, Jung-Chen
    Che, Xuan
    Christophi, Costas A
    Chugh, Sumeet S
    Cirillo, Massimo
    Colquhoun, Samantha M
    Cooper, Leslie Trumbull
    Cooper, Cyrus
    da Costa Leite, Iuri
    Dandona, Lalit
    Dandona, Rakhi
    Davis, Adrian
    Dayama, Anand
    Degenhardt, Louisa
    De Leo, Diego
    Del Pozo-Cruz, Borja
    Deribe, Kebede
    Dessalegn, Muluken
    Deveber, Gabrielle A
    Dharmaratne, Samath D
    Dilmen, Uğur
    Ding, Eric L
    Dorrington, Rob E
    Driscoll, Tim R
    Ermakov, Sergei Petrovich
    Esteghamati, Alireza
    Faraon, Emerito Jose A
    Farzadfar, Farshad
    Felicio, Manuela Mendonca
    Fereshtehnejad, Seyed-Mohammad
    de Lima, Graça Maria Ferreira
    Forouzanfar, Mohammad H
    França, Elisabeth B
    Gaffikin, Lynne
    Gambashidze, Ketevan
    Gankpé, Fortuné Gbètoho
    Garcia, Ana C
    Geleijnse, Johanna M
    Gibney, Katherine B
    Giroud, Maurice
    Glaser, Elizabeth L
    Goginashvili, Ketevan
    Gona, Philimon
    González-Castell, Dinorah
    Goto, Atsushi
    Gouda, Hebe N
    Gugnani, Harish Chander
    Gupta, Rahul
    Gupta, Rajeev
    Hafezi-Nejad, Nima
    Hamadeh, Randah Ribhi
    Hammami, Mouhanad
    Hankey, Graeme J
    Harb, Hilda L
    Havmoeller, Rasmus
    Hay, Simon
    Pi, Ileana B Heredia
    Hoek, Hans W
    Hosgood, H Dean
    Hoy, Damian G
    Husseini, Abdullatif
    Idrisov, Bulat T
    Innos, Kaire
    Inoue, Manami
    Jacobsen, Kathryn H
    Jahangir, Eiman
    Jee, Sun Ha
    Jensen, Paul N
    Jha, Vivekanand
    Jiang, Guohong
    Juel, Knud
    Kabagambe, Edmond Kato
    Kan, Haidong
    Karam, Nadim E
    Karch, André
    Karema, Corine Kakizi
    Kaul, Anil
    Kawakami, Norito
    Kazanjan, Konstantin
    Kazi, Dhruv S
    Kemp, Andrew G
    Kengne, Andre Pascal
    Kereselidze, Maia
    Khader, Yousef Saleh
    Khalifa, Shams Eldin Ali Hassan
    Khan, Ejaz Ahmed
    Khang, Young-Ho
    Knibbs, Luke
    Kokubo, Yoshihiro
    Kosen, Soewarta
    Defo, Barthelemy Kuate
    Kulkarni, Chanda
    Kulkarni, Veena S
    Kumar, G Anil
    Kumar, Kaushalendra
    Kumar, Ravi B
    Kwan, Gene
    Lai, Taavi
    Lalloo, Ratilal
    Lam, Hilton
    Lansingh, Van C
    Larsson, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
    Lee, Jong-Tae
    Leigh, James
    Leinsalu, Mall
    Leung, Ricky
    Li, Xiaohong
    Li, Yichong
    Li, Yongmei
    Liang, Juan
    Liang, Xiaofeng
    Lim, Stephen S
    Lin, Hsien-Ho
    Lipshultz, Steven E
    Liu, Shiwei
    Liu, Yang
    Lloyd, Belinda K
    London, Stephanie J
    Lotufo, Paulo A
    Ma, Jixiang
    Ma, Stefan
    Machado, Vasco Manuel Pedro
    Mainoo, Nana Kwaku
    Majdan, Marek
    Mapoma, Christopher Chabila
    Marcenes, Wagner
    Marzan, Melvin Barrientos
    Mason-Jones, Amanda J
    Mehndiratta, Man Mohan
    Mejia-Rodriguez, Fabiola
    Memish, Ziad A
    Mendoza, Walter
    Miller, Ted R
    Mills, Edward J
    Mokdad, Ali H
    Mola, Glen Liddell
    Monasta, Lorenzo
    de la Cruz Monis, Jonathan
    Hernandez, Julio Cesar Montañez
    Moore, Ami R
    Mori, Rintaro
    Mueller, Ulrich O
    Mukaigawara, Mitsuru
    Naheed, Aliya
    Naidoo, Kovin S
    Nand, Devina
    Nangia, Vinay
    Nash, Denis
    Nejjari, Chakib
    Nelson, Robert G
    Neupane, Sudan Prasad
    Newton, Charles R
    Ng, Marie
    Nieuwenhuijsen, Mark J
    Nisar, Muhammad Imran
    Nolte, Sandra
    Norheim, Ole F
    Nyakarahuka, Luke
    Oh, In-Hwan
    Ohkubo, Takayoshi
    Olusanya, Bolajoko O
    Omer, Saad B
    Opio, John Nelson
    Orisakwe, Orish Ebere
    Pandian, Jeyaraj D
    Papachristou, Christina
    Park, Jae-Hyun
    Caicedo, Angel J Paternina
    Patten, Scott B
    Paul, Vinod K
    Pavlin, Boris Igor
    Pearce, Neil
    Pereira, David M
    Pesudovs, Konrad
    Petzold, Max
    Poenaru, Dan
    Polanczyk, Guilherme V
    Polinder, Suzanne
    Pope, Dan
    Pourmalek, Farshad
    Qato, Dima
    Quistberg, D Alex
    Rafay, Anwar
    Rahimi, Kazem
    Rahimi-Movaghar, Vafa
    Ur Rahman, Sajjad
    Raju, Murugesan
    Rana, Saleem M
    Refaat, Amany
    Ronfani, Luca
    Roy, Nobhojit
    Pimienta, Tania Georgina Sánchez
    Sahraian, Mohammad Ali
    Salomon, Joshua
    Sampson, Uchechukwu
    Santos, Itamar S
    Sawhney, Monika
    Sayinzoga, Felix
    Schneider, Ione J C
    Schumacher, Austin
    Schwebel, David C
    Seedat, Soraya
    Sepanlou, Sadaf G
    Servan-Mori, Edson E
    Shakh-Nazarova, Marina
    Sheikhbahaei, Sara
    Shibuya, Kenji
    Shin, Hwashin Hyun
    Shiue, Ivy
    Sigfusdottir, Inga Dora
    Silberberg, Donald H
    Silva, Andrea P
    Singh, Jasvinder A
    Skirbekk, Vegard
    Sliwa, Karen
    Soshnikov, Sergey S
    Sposato, Luciano A
    Sreeramareddy, Chandrashekhar T
    Stroumpoulis, Konstantinos
    Sturua, Lela
    Sykes, Bryan L
    Tabb, Karen M
    Talongwa, Roberto Tchio
    Tan, Feng
    Teixeira, Carolina Maria
    Tenkorang, Eric Yeboah
    Terkawi, Abdullah Sulieman
    Thorne-Lyman, Andrew L
    Tirschwell, David L
    Towbin, Jeffrey A
    Tran, Bach X
    Tsilimbaris, Miltiadis
    Uchendu, Uche S
    Ukwaja, Kingsley N
    Undurraga, Eduardo A
    Uzun, Selen Begüm
    Vallely, Andrew J
    van Gool, Coen H
    Vasankari, Tommi J
    Vavilala, Monica S
    Venketasubramanian, N
    Villalpando, Salvador
    Violante, Francesco S
    Vlassov, Vasiliy Victorovich
    Vos, Theo
    Waller, Stephen
    Wang, Haidong
    Wang, Linhong
    Wang, Sharon Xiaorong
    Wang, Yanping
    Weichenthal, Scott
    Weiderpass, Elisabete
    Weintraub, Robert G
    Westerman, Ronny
    Wilkinson, James D
    Woldeyohannes, Solomon Meseret
    Wong, John Q
    Wordofa, Muluemebet Abera
    Xu, Gelin
    Yang, Yang C
    Yano, Yuichiro
    Yentur, Gokalp Kadri
    Yip, Paul
    Yonemoto, Naohiro
    Yoon, Seok-Jun
    Younis, Mustafa Z
    Yu, Chuanhua
    Jin, Kim Yun
    El Sayed Zaki, Maysaa
    Zhao, Yong
    Zheng, Yingfeng
    Zhou, Maigeng
    Zhu, Jun
    Zou, Xiao Nong
    Lopez, Alan D
    Naghavi, Mohsen
    Murray, Christopher J L
    Lozano, Rafael
    Global, regional, and national levels and causes of maternal mortality during 1990-2013: a systematic analysis for the Global Burden of Disease Study 20132014In: The Lancet, ISSN 0140-6736, E-ISSN 1474-547X, Vol. 384, no 9947, p. 980-1004Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: The fifth Millennium Development Goal (MDG 5) established the goal of a 75% reduction in the maternal mortality ratio (MMR; number of maternal deaths per 100 000 livebirths) between 1990 and 2015. We aimed to measure levels and track trends in maternal mortality, the key causes contributing to maternal death, and timing of maternal death with respect to delivery.

    METHODS: We used robust statistical methods including the Cause of Death Ensemble model (CODEm) to analyse a database of data for 7065 site-years and estimate the number of maternal deaths from all causes in 188 countries between 1990 and 2013. We estimated the number of pregnancy-related deaths caused by HIV on the basis of a systematic review of the relative risk of dying during pregnancy for HIV-positive women compared with HIV-negative women. We also estimated the fraction of these deaths aggravated by pregnancy on the basis of a systematic review. To estimate the numbers of maternal deaths due to nine different causes, we identified 61 sources from a systematic review and 943 site-years of vital registration data. We also did a systematic review of reports about the timing of maternal death, identifying 142 sources to use in our analysis. We developed estimates for each country for 1990-2013 using Bayesian meta-regression. We estimated 95% uncertainty intervals (UIs) for all values.

    FINDINGS: 292 982 (95% UI 261 017-327 792) maternal deaths occurred in 2013, compared with 376 034 (343 483-407 574) in 1990. The global annual rate of change in the MMR was -0·3% (-1·1 to 0·6) from 1990 to 2003, and -2·7% (-3·9 to -1·5) from 2003 to 2013, with evidence of continued acceleration. MMRs reduced consistently in south, east, and southeast Asia between 1990 and 2013, but maternal deaths increased in much of sub-Saharan Africa during the 1990s. 2070 (1290-2866) maternal deaths were related to HIV in 2013, 0·4% (0·2-0·6) of the global total. MMR was highest in the oldest age groups in both 1990 and 2013. In 2013, most deaths occurred intrapartum or postpartum. Causes varied by region and between 1990 and 2013. We recorded substantial variation in the MMR by country in 2013, from 956·8 (685·1-1262·8) in South Sudan to 2·4 (1·6-3·6) in Iceland.

    INTERPRETATION: Global rates of change suggest that only 16 countries will achieve the MDG 5 target by 2015. Accelerated reductions since the Millennium Declaration in 2000 coincide with increased development assistance for maternal, newborn, and child health. Setting of targets and associated interventions for after 2015 will need careful consideration of regions that are making slow progress, such as west and central Africa.

  • 181. Kassebaum, Nicholas J
    et al.
    Jörgensen, Bo
    Aarhus University.
    Cotterill, Carol
    British Geological Survey.
    Green, S
    British Geological Survey.
    The Global Burden of Anemia2016In: Scientific Drilling, ISSN 1816-8957, E-ISSN 1816-3459, Vol. 30, no 2, p. 247-308Article in journal (Refereed)
    Abstract [en]

    Anemia is an important cause of health loss. We estimated levels and trends of nonfatal anemia burden for 23 distinct etiologies in 188 countries, 20 age groups, and both sexes from 1990 to 2013. All available population-level anemia data were collected and standardized. We estimated mean hemoglobin, prevalence of anemia by severity, quantitative disability owing to anemia, and underlying etiology for each population using the approach of the Global Burden of Disease, Injuries and Risk Factors 2013 Study. Anemia burden is high. Developing countries account for 89% of all anemia-related disability. Iron-deficiency anemia remains the dominant cause of anemia.

  • 182.
    Katja, Junus
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Obstetrics and Gynaecology.
    Anna-Karin, Wikström
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Obstetrics and Gynaecology.
    Anders, Larsson
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
    Olovsson, Matts
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Obstetrics and Gynaecology.
    PP015. Plasma levels and placental expression of BNP/NT-proBNP in early and late onset preeclampsia2013In: Pregnancy Hypertension, ISSN 2210-7789, E-ISSN 2210-7797, Vol. 3, no 2, p. 73-Article in journal (Refereed)
    Abstract [en]

    INTRODUCTION:

    Women with preeclampsia (PE) have elevated plasma levels of NT-proBNP. We hypothesized that the placenta may be a source to these elevated levels.

    OBJECTIVES:

    Our objectives were to study the plasma levels of NT-proBNP and the protein and mRNA expression of placental BNP in women with early and late onset PE and controls.

    METHODS:

    Plasma levels of NT-proBNP were measured in women with early (n=18) and late (n=20) onset PE, in two groups of healthy pregnant women in gestational week 24-32 (n=22) and 36-42 (n=14), and in non-pregnant women (n=20). Placental BNP protein and mRNA was studied with immunohistochemistry and qPCR. Placental release of NT-proBNP was studied with tissue culturing.

    RESULTS:

    Women with early (365 (14-9815) pg/ml) and late (176 (33-2547) pg/ml) onset PE had higher levels of NT-proBNP in plasma than their respective controls (p<0.001). A tendency towards higher plasma levels in early compared to late onset PE was observed (p=0.057). 20 out of 25 placental tissue samples had proBNP mRNA, no differences between the study groups were found. BNP protein was found in maternal spiral arteries and syncytiotrophoblasts. NT-proBNP peptide (6-7pg/ml) was present in medium used for placenta cultures.

    CONCLUSIONS:

    Our results suggest that there may be a placental source of NT-proBNP. If this source is responsible for the elevated plasma levels of NT-proBNP in preeclamptic women and what role, if any, BNP/NT-proBNP play in PE pathophysiology remains to be elucidated.

  • 183.
    Khezri, Banafsheh
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
    Helmersson-Karlqvist, Johanna
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
    Larsson, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
    Estimation of the possible economic effects of a sequential testing strategy with NT-proBNP before echocardiography in primary care2014In: Clinical Laboratory, ISSN 1433-6510, Vol. 60, no 7-8, p. 881-886Article in journal (Refereed)
    Abstract [en]

    BACKGROUND:

    The object of the study was to estimate the possible economic effects of a sequential testing strategy with NT-proBNP from a primary care payer perspective.

    METHODS:

    The study data were collected from primary care physicians in the County of Uppland from 2005 through 2012. Two different cut-off levels were used for negative NT-proBNP in the rule-out test: 300 and 400 pg/mL. The cost-effectiveness of the testing strategy was estimated through the short-term cost avoidance and reduction in demand for echocardiographies.

    RESULTS:

    The female patients were slightly older than the males. Based on the data from 2012, the estimated costs for NT-proBNP tests and echocardiographies per county were reduced by EUR 300000/100000 inhabitants with the 300 pg/mL cut-off and EUR 350000/100000 inhabitants with the 400 pg/mL.

    CONCLUSIONS:

    The use of NT-proBNP as a rule-out test in a sequential testing strategy reduced the cost for diagnostic work-up of primary care patients with suspected heart failure.

  • 184.
    Khezri, Banafsheh Seyyed
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
    Carlsson, Lena
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
    Larsson, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
    Evaluation of the Alere NT-proBNP Test for Point of Care Testing2016In: Journal of clinical laboratory analysis (Print), ISSN 0887-8013, E-ISSN 1098-2825, Vol. 30, no 4, p. 290-292Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: The object of the study was to evaluate the Alere point of care NT-proBNP assay as a suitable alternative to the central laboratory method to provide short test turnaround times in primary care.

    METHOD: Blood NT-proBNP results obtained with the Alere assay (n = 100) were compared with serum NT-proBNP results analyzed by a Cobas 8000 analyzer (Roche Diagnostics, Mannheim, Germany).

    RESULTS: There was a good agreement between the two NT-proBNP methods when used as a rule-out test for heart failure (HF) and the cut-off value <300 ng/l. A total of 47 samples gave values <300 ng/L with both methods and 51 samples gave values >300 with both methods. Thus, there was an agreement for 98% of the samples.

    CONCLUSIONS: The study shows that the Alere NT-proBNP assay could be used in primary care permitting rapid NT-proBNP testing to rule out HF.

  • 185.
    Khezri, Banafsheh Seyyed
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    Cederblad, Maria
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Helmersson-Karlqvist, Johanna
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry.
    Karlsson, Bo
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Melhus, Håkan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    Larsson, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry.
    Seasonal variability of NT-proBNP in Swedish primary care patients2017In: Chronobiology International, ISSN 0742-0528, E-ISSN 1525-6073, Vol. 34, no 10, p. 1473-1477Article in journal (Refereed)
    Abstract [en]

    The aim of this study was to determine if there is a seasonal variation in the widely used heart failure marker NT-proBNP. The study included all primary care requests for NT-proBNP in the county of Uppsala, Sweden, between January 2007 and December 2015. For seasonal variation, the NT-proBNP results for individual months were compared. The NT-proBNP values were highest in July to September, but there was also a minor peak in December-January. In conclusion, a seasonal periodicity for NT-proBNP was demonstrated in primary care patients. The data could be useful for practitioners for evaluation of NT-proBNP results and monitoring of patients with heart failure.

  • 186.
    Kollberg, Hans
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.
    Carlander, David
    Olesen, Hanne
    Wejåker, Per-Erik
    Johannesson, Marie
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.
    Larsson, Anders
    Oral administration of specific yolk antibodies (IgY) may prevent Pseudomonas aeruginosa infections in patients with cystic fibrosis: a phase I feasibility study2003In: Pediatric Pulmonology, ISSN 8755-6863, E-ISSN 1099-0496, Vol. 35, no 6, p. 433-40Article in journal (Refereed)
    Abstract [en]

    Respiratory infection is the major cause of morbidity and mortality in cystic fibrosis (CF) patients. Chronic Pseudomonas aeruginosa (PA) infections ultimately occur in virtually all patients. It is impossible to eradicate PA when a patient has been chronically colonized. Immunotherapy with specific egg-yolk antibodies (IgY) may be an alternative to antibiotics for the prevention of PA infections. We wanted to determine if treatment with specific IgY can prolong the period between the first and the second PA colonization? And long-term, can the treatment diminish the number of positive PA cultures and postpone the onset of chronic colonization? CF patients gargled daily with an IgY-antibody preparation, purified from eggs of hens immunized with PA bacteria. They were compared to a group of patients who did not gargle with the preparation. Both groups had their first colonization with PA eradicated by antibiotics. The basic treatment was essentially the same in both groups. In the initial study, the period between the first and second colonization with PA was significantly prolonged for the treated vs. the control group (Kaplan-Meier P = 0.015, Breslow test). In the prolonged study, the treated group had only 2.5 sputum cultures positive for PA per 100 months of observation, and none of these patients became chronically colonized with PA. No adverse events were reported. In the control group, 13.7 cultures per 100 months of observation were positive for PA, and 5 (24%) patients became chronically colonized with PA. This feasibility study shows that antipseudomonal IgY has the potential to effectively prevent PA colonization without any severe adverse effects. A phase III study should be initiated.

  • 187. Kyu, Hmwe H
    et al.
    Pinho, Christine
    Wagner, Joseph A
    Brown, Jonathan C
    Bertozzi-Villa, Amelia
    Charlson, Fiona J
    Coffeng, Luc Edgar
    Dandona, Lalit
    Erskine, Holly E
    Ferrari, Alize J
    Fitzmaurice, Christina
    Fleming, Thomas D
    Forouzanfar, Mohammad H
    Graetz, Nicholas
    Guinovart, Caterina
    Haagsma, Juanita
    Higashi, Hideki
    Kassebaum, Nicholas J
    Larson, Heidi J
    Lim, Stephen S
    Mokdad, Ali H
    Moradi-Lakeh, Maziar
    Odell, Shaun V
    Roth, Gregory A
    Serina, Peter T
    Stanaway, Jeffrey D
    Misganaw, Awoke
    Whiteford, Harvey A
    Wolock, Timothy M
    Wulf Hanson, Sarah
    Abd-Allah, Foad
    Abera, Semaw Ferede
    Abu-Raddad, Laith J
    AlBuhairan, Fadia S
    Amare, Azmeraw T
    Antonio, Carl Abelardo T
    Artaman, Al
    Barker-Collo, Suzanne L
    Barrero, Lope H
    Benjet, Corina
    Bensenor, Isabela M
    Bhutta, Zulfiqar A
    Bikbov, Boris
    Brazinova, Alexandra
    Campos-Nonato, Ismael
    Castañeda-Orjuela, Carlos A
    Catalá-López, Ferrán
    Chowdhury, Rajiv
    Cooper, Cyrus
    Crump, John A
    Dandona, Rakhi
    Degenhardt, Louisa
    Dellavalle, Robert P
    Dharmaratne, Samath D
    Faraon, Emerito Jose A
    Feigin, Valery L
    Fürst, Thomas
    Geleijnse, Johanna M
    Gessner, Bradford D
    Gibney, Katherine B
    Goto, Atsushi
    Gunnell, David
    Hankey, Graeme J
    Hay, Roderick J
    Hornberger, John C
    Hosgood, H Dean
    Hu, Guoqing
    Jacobsen, Kathryn H
    Jayaraman, Sudha P
    Jeemon, Panniyammakal
    Jonas, Jost B
    Karch, André
    Kim, Daniel
    Kim, Sungroul
    Kokubo, Yoshihiro
    Kuate Defo, Barthelemy
    Kucuk Bicer, Burcu
    Kumar, G Anil
    Larsson, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
    Leasher, Janet L
    Leung, Ricky
    Li, Yongmei
    Lipshultz, Steven E
    Lopez, Alan D
    Lotufo, Paulo A
    Lunevicius, Raimundas
    Lyons, Ronan A
    Majdan, Marek
    Malekzadeh, Reza
    Mashal, Taufiq
    Mason-Jones, Amanda J
    Melaku, Yohannes Adama
    Memish, Ziad A
    Mendoza, Walter
    Miller, Ted R
    Mock, Charles N
    Murray, Joseph
    Nolte, Sandra
    Oh, In-Hwan
    Olusanya, Bolajoko Olubukunola
    Ortblad, Katrina F
    Park, Eun-Kee
    Paternina Caicedo, Angel J
    Patten, Scott B
    Patton, George C
    Pereira, David M
    Perico, Norberto
    Piel, Frédéric B
    Polinder, Suzanne
    Popova, Svetlana
    Pourmalek, Farshad
    Quistberg, D Alex
    Remuzzi, Giuseppe
    Rodriguez, Alina
    Rojas-Rueda, David
    Rothenbacher, Dietrich
    Rothstein, David H
    Sanabria, Juan
    Santos, Itamar S
    Schwebel, David C
    Sepanlou, Sadaf G
    Shaheen, Amira
    Shiri, Rahman
    Shiue, Ivy
    Skirbekk, Vegard
    Sliwa, Karen
    Sreeramareddy, Chandrashekhar T
    Stein, Dan J
    Steiner, Timothy J
    Stovner, Lars Jacob
    Sykes, Bryan L
    Tabb, Karen M
    Terkawi, Abdullah Sulieman
    Thomson, Alan J
    Thorne-Lyman, Andrew L
    Towbin, Jeffrey Allen
    Ukwaja, Kingsley Nnanna
    Vasankari, Tommi
    Venketasubramanian, Narayanaswamy
    Vlassov, Vasiliy Victorovich
    Vollset, Stein Emil
    Weiderpass, Elisabete
    Weintraub, Robert G
    Werdecker, Andrea
    Wilkinson, James D
    Woldeyohannes, Solomon Meseret
    Wolfe, Charles D A
    Yano, Yuichiro
    Yip, Paul
    Yonemoto, Naohiro
    Yoon, Seok-Jun
    Younis, Mustafa Z
    Yu, Chuanhua
    El Sayed Zaki, Maysaa
    Naghavi, Mohsen
    Murray, Christopher J L
    Vos, Theo
    Global and National Burden of Diseases and Injuries Among Children and Adolescents Between 1990 and 2013: Findings From the Global Burden of Disease 2013 Study2016In: JAMA pediatrics, ISSN 2168-6203, E-ISSN 2168-6211, Vol. 170, no 3, p. 267-287Article, review/survey (Refereed)
    Abstract [en]

    Importance: The literature focuses on mortality among children younger than 5 years. Comparable information on nonfatal health outcomes among these children and the fatal and nonfatal burden of diseases and injuries among older children and adolescents is scarce.

    Objective: To determine levels and trends in the fatal and nonfatal burden of diseases and injuries among younger children (aged <5 years), older children (aged 5-9 years), and adolescents (aged 10-19 years) between 1990 and 2013 in 188 countries from the Global Burden of Disease (GBD) 2013 study.

    Evidence Review: Data from vital registration, verbal autopsy studies, maternal and child death surveillance, and other sources covering 14 244 site-years (ie, years of cause of death data by geography) from 1980 through 2013 were used to estimate cause-specific mortality. Data from 35 620 epidemiological sources were used to estimate the prevalence of the diseases and sequelae in the GBD 2013 study. Cause-specific mortality for most causes was estimated using the Cause of Death Ensemble Model strategy. For some infectious diseases (eg, HIV infection/AIDS, measles, hepatitis B) where the disease process is complex or the cause of death data were insufficient or unavailable, we used natural history models. For most nonfatal health outcomes, DisMod-MR 2.0, a Bayesian metaregression tool, was used to meta-analyze the epidemiological data to generate prevalence estimates.

    Findings: Of the 7.7 (95% uncertainty interval [UI], 7.4-8.1) million deaths among children and adolescents globally in 2013, 6.28 million occurred among younger children, 0.48 million among older children, and 0.97 million among adolescents. In 2013, the leading causes of death were lower respiratory tract infections among younger children (905 059 deaths; 95% UI, 810 304-998 125), diarrheal diseases among older children (38 325 deaths; 95% UI, 30 365-47 678), and road injuries among adolescents (115 186 deaths; 95% UI, 105 185-124 870). Iron deficiency anemia was the leading cause of years lived with disability among children and adolescents, affecting 619 (95% UI, 618-621) million in 2013. Large between-country variations exist in mortality from leading causes among children and adolescents. Countries with rapid declines in all-cause mortality between 1990 and 2013 also experienced large declines in most leading causes of death, whereas countries with the slowest declines had stagnant or increasing trends in the leading causes of death. In 2013, Nigeria had a 12% global share of deaths from lower respiratory tract infections and a 38% global share of deaths from malaria. India had 33% of the world's deaths from neonatal encephalopathy. Half of the world's diarrheal deaths among children and adolescents occurred in just 5 countries: India, Democratic Republic of the Congo, Pakistan, Nigeria, and Ethiopia.

    Conclusions and Relevance: Understanding the levels and trends of the leading causes of death and disability among children and adolescents is critical to guide investment and inform policies. Monitoring these trends over time is also key to understanding where interventions are having an impact. Proven interventions exist to prevent or treat the leading causes of unnecessary death and disability among children and adolescents. The findings presented here show that these are underused and give guidance to policy makers in countries where more attention is needed.

  • 188.
    Lannergård, Anders
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Infectious Diseases.
    Friman, Göran
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Infectious Diseases.
    Ewald, Uwe
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.
    Lind, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    Larsson, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry.
    Serum amyloid A (SAA) protein and high-sensitivity C-reactive protein (hsCRP) in healthy newborn infants and healthy young through elderly adults2005In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 94, no 9, p. 1198-1202Article in journal (Refereed)
    Abstract [en]

    AIM:

    To determine the levels of serum amyloid A (SAA) protein and high-sensitivity C-reactive protein (hsCRP) in different age groups.

    METHODS:

    Serum samples from 70 healthy newborn infants, 80 blood donors and 81 healthy elderly individuals were analysed using a nephelometric method. The 231 samples were grouped as follows: 35 umbilical cords, 35 newborns, 48 young adults, 28 middle-aged adults, and 85 elderly adults.

    RESULTS:

    Serum levels of both SAA and hsCRP were lower in umbilical cords than in the newborns and young, middle-aged and elderly adults (p<0.0001). The SAA and hsCRP levels were comparable in newborns, and young and middle-age adults, but higher in elderly adults (p<0.0001-0.03). SAA (r2=0.159, p<0.0001) and hsCRP (r2=0.059, p<0.0001) were positively correlated with age and to each other (r2=0.385, p<0.0001).

    CONCLUSION:

    Serum levels of SAA and hsCRP in umbilical cord blood are close to the detection limit and lower than in the other age groups investigated. The elderly have generally higher levels than the younger age groups, which require higher decision levels in inflammatory diseases, including infections. In newborns and young and middle-aged adults, the lower decision levels of 10 mg/l for SAA and 5 mg/l for CRP are suggested.

  • 189. Larssen, Pia
    et al.
    Wik, Lotta
    Uppsala University, Science for Life Laboratory, SciLifeLab.
    Czarnewski, Paulo
    Eldh, Maria
    Löf, Liza
    Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology.
    Ronquist, Göran
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
    Dubois, Louise
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
    Freyhult, Eva
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cancer Pharmacology and Computational Medicine. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Gallant, Caroline
    Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology.
    Oelrich, Johan
    Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Molecular tools.
    Larsson, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
    Ronquist, Gunnar
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
    Villablanca, Eduardo
    Landegren, Ulf
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Gabrielsson, Susanne
    Kamali-Moghaddam, Masood
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Tracing Cellular Origin of Human Exosomes Using Multiplex Proximity Extension Assay2017In: Molecular & cellular proteomics (online), ISSN 1535-9476, E-ISSN 1535-9484, Vol. 16, no 3, p. 502-511Article in journal (Refereed)
    Abstract [en]

    Extracellular vesicles (EVs) are membrane-coated objects such as exosomes and microvesicles, released by many cell-types. Their presence in body fluids and the variable surface composition and content render them attractive potential biomarkers. The ability to determine their cellular origin could greatly move the field forward. We used multiplex proximity extension assays (PEA) to identify with high specificity and sensitivity the protein profiles of exosomes of different origins, including seven cell lines and two different body fluids. By comparing cells and exosomes, we successfully identified the cells originating the exosomes. Furthermore, by principal component analysis of protein patterns human milk EVs and prostasomes released from prostate acinar cells clustered with cell lines from breast and prostate tissues, respectively. Milk exosomes uniquely expressed CXCL5, MIA and KLK6, while prostasomes carried NKX31, GSTP1 and SRC, highlighting that EVs originating from different origins express distinct proteins. In conclusion, PEA provides a powerful protein screening tool in exosome research, for purposes of identifying the cell source of exosomes, or new biomarkers in diseases such as cancer and inflammation.

  • 190.
    Larsson, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry.
    Author response to: Reference values for clinical chemistry tests during normal pregnancy2008In: British Journal of Obstetrics and Gynecology, ISSN 1470-0328, E-ISSN 1471-0528, Vol. 115, no 13, p. 1716-1717Article in journal (Refereed)
  • 191.
    Larsson, Anders
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Medical Sciences. klinisk kemi.
    Autoantikroppstest – även intressant prognostisk markör för prostatacancer.2006In: Läkartidningen, Vol. 103, no 30, p. 2211-Article in journal (Refereed)
  • 192.
    Larsson, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
    Blood pressure and chronic kidney disease progression in a multi-racial cohort: the Multi-Ethnic Study of Atherosclerosis2013In: Journal of Human Hypertension, ISSN 0950-9240, E-ISSN 1476-5527, Vol. 27, no 7, p. 403-404Article in journal (Refereed)
  • 193.
    Larsson, Anders
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Medical Sciences. klinisk kemi.
    Cystatin C: an emerging glomerular filtration rate marker.2005In: Scand J Clin Lab Invest, ISSN 0036-5513, Vol. 65, no 2, p. 89-91Article in journal (Refereed)
  • 194.
    Larsson, Anders
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Medical Sciences. klinisk kemi.
    Cystatin C. En bra glomerulär filtrationsmarkör men även en intressant riskmarkör2004In: Klinisk Biokemi i Norden, Vol. 16, p. 24-26Article in journal (Other (popular scientific, debate etc.))
  • 195.
    Larsson, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry.
    Reference values for clinical chemistry tests during normal pregnancy: Author's reply2008In: British Journal of Obstetrics and Gynecology, ISSN 1470-0328, E-ISSN 1471-0528, Vol. 115, no 12, p. 1580-1581Article in journal (Refereed)
  • 196.
    Larsson, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry.
    What can we learn from studies on regional differences in the utilization of laboratory tests?2011In: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 116, no 4, p. 225-226Article in journal (Refereed)
  • 197.
    Larsson, Anders
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry.
    Breimer, Lars
    laboratoriemedicinska kliniken, Universitetssjukhuset Örebro.
    Anpassa utredningen av diabetes hos patienter med invandrarbakgrund.2018In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 115, p. FFIZ-Article in journal (Refereed)
  • 198.
    Larsson, Anders
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry.
    Breimer, Lars
    Örebro Universitet.
    Anpassa utredningen av diabetes hos patienter med invandrarbakgrund.2018In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 115, p. FFIZ-FFIZArticle in journal (Refereed)
  • 199.
    Larsson, Anders
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry.
    Breimer, Lars
    Örebro Universiet.
    Bra att läkare inte stirrar sig blinda på HbA1c2019In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 116, p. FIEW-Article in journal (Other academic)
  • 200.
    Larsson, Anders
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    Carlsson, Lena
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    Axelsson, John
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    Low diurnal variability of apolipoprotein A1, apolipoprotein B and apolipoprotein B/apolipoprotein A1 ratio during normal sleep and after an acute shift of sleep2008In: Clinical Biochemistry, ISSN 0009-9120, E-ISSN 1873-2933, Vol. 41, no 10-11, p. 859-862Article in journal (Refereed)
    Abstract [en]

    OBJECTIVE: The aim of this study was to study the diurnal variation of the cardiovascular risk markers apolipoprotein A1 and B and apo B/apo A1 ratio. DESIGN AND METHODS: We have studied the diurnal variation of apolipoprotein A1, apolipoprotein B and apo B/apo A1 ratio during night sleep and the day sleep conditions in seven healthy volunteers (age 22-32 yr). Samples were collected every hour to evaluate the effect of different sampling times on the test results. RESULTS: The lowest diurnal coefficient of variation (CV) was observed for the apo B/apo A1 ratio, which usually was below 2% but also apolipoprotein A1, apolipoprotein B showed low CV. There were no significant differences between nightsleep and daysleep for any of the studied markers. CONCLUSION: Even if there was a diurnal variation for these markers, the variation was very low. Thus, sampling does not have to be restricted to certain times of the day.

1234567 151 - 200 of 415
CiteExportLink to result list
Permanent link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf