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  • 1179651.
    Zhu, Lin
    KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Structural Biotechnology.
    Structural studies of HDL and applications of EM on membrane proteins2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    A large number of proteins interact with biological membranes, either integrated in the membrane (PepTSo2), embedded on a membrane surface (5-lipoxygenase) or encircling a cutout of lipid bilayer (apolipoprotein1 (apoA-I). They function as transporters, receptors or biocatalysts in cellular processes like inflammation or cholesterol transport which are touched upon here. Malfunction of specific membrane proteins are the cause for several diseases or disorders.

    Knowledge of protein structure supports understanding of its mechanism of function. Here, transmission electron microscopy (TEM) was used for structure determination. To obtain structure information to high resolution for membrane proteins, normally surrounded by lipids, demands specific methods and materials for stabilization. Stabilized in detergent the structure of the bacterial transporter PepTSo2 was shown to form a tetramer even bound to substrate. However, with a protein based stabilizer, Salipro, the structure of PepTSo2 could be determined to high resolution.

    High density lipoprotein (HDL) in blood plasma, involved in the removal of cholesterol from peripheral tissues, have a central role in cardiovascular function, metabolic syndrome and diabetes.

    The HDL-particle is composed of two copies of ApoA1 and around hundred lipid molecules. From TEM data, for the first time the clearly discoidal shape could be shown by 3-dimendional reconstructions. These were used for modelling the ApoA1 protein dimer by a "biased fitting" procedure. The results indicate how ApoA1 folds around a lipid bilayer in a disc-shaped structure.

    Modified HDL called nanodiscs were here used to show the Ca2+ dependent binding of 5-lipoxygenase on the nanodisc bilayer and thereby increased production of the inflammatory mediator leukotrieneA4. Dimerization of 5-lipoxygenase inactivates these functions.

  • 1179652.
    Zhu, Lin
    KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Structural Biotechnology.
    Structural Studies of High Density Lipoprotein by Electron Microscopy and Flexible FittingManuscript (preprint) (Other academic)
  • 1179653.
    Zhu, Lin
    et al.
    KTH, School of Technology and Health (STH), Medical Engineering, Structural Biotechnology. Karolinska Institutet, Sweden.
    Petrlova, J.
    Gysbers, P.
    Hebert, Hans
    KTH, School of Technology and Health (STH), Medical Engineering, Structural Biotechnology. Karolinska Institutet, Sweden.
    Wallin, S.
    Jegerschöld, Caroline
    KTH, School of Technology and Health (STH). Karolinska Institutet, Sweden.
    Lagerstedt, J. O.
    Structures of apolipoprotein A-I in high density lipoprotein generated by electron microscopy and biased simulations2017In: Biochimica et Biophysica Acta - General Subjects, ISSN 0304-4165, E-ISSN 1872-8006, Vol. 1861, no 11, p. 2726-2738Article in journal (Refereed)
    Abstract [en]

    Background: Apolipoprotein A-I (apoA-I) in high-density lipoprotein (HDL) is a key protein for the transport of cholesterol from the vascular wall to the liver. The formation and structure of nascent HDL, composed of apoA-I and phospholipids, is critical to this process. Methods: The HDL was assembled in vitro from apoA-I, cholesterol and 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) at a 1:4:50 molar ratio. The structure of HDL was investigated in vitreous samples, frozen at cryogenic temperatures, as well as in negatively stained samples by transmission electron microscopy. Low resolution electron density maps were next used as restraints in biased Monte Carlo simulations of apolipoprotein A-I dimers, with an initial structure derived from atomic resolution X-ray structures. Results: Two final apoA-I structure models for the full-length structure of apoA-I dimer in the lipid bound conformation were generated, showing a nearly circular, flat particle with an uneven particle thickness. Conclusions: The generated structures provide evidence for the discoidal, antiparallel arrangement of apoA-I in nascent HDL, and propose two preferred conformations of the flexible N-termini.

  • 1179654.
    Zhu, Ling
    et al.
    University of Oxford, UK ; The Pirbright Institute, UK.
    Wang, Xiangxi
    Chinese Academy of Science, China.
    Ren, Jingshan
    University of Oxford, UK.
    Porta, Claudine
    University of Oxford, UK ; The Pirbright Institute, UK.
    Wenham, Hannah
    The Pirbright Institute, UK.
    Ekström, Jens-Ola
    Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences.
    Panjwani, Anusha
    The Pirbright Institute, UK.
    Knowles, Nick J.
    The Pirbright Institute, UK.
    Kotecha, Abhay
    University of Oxford, UK.
    Siebert, C. Alistair
    University of Oxford, UK.
    Lindberg, A. Michael
    Linnaeus University, Faculty of Health and Life Sciences, Department of Chemistry and Biomedical Sciences.
    Fry, Elizabeth E.
    University of Oxford, UK.
    Rao, Zihe
    Chinese Academy of Science, China ; Tsinghua University, China.
    Tuthill, Tobias J.
    The Pirbright Institute, UK.
    Stuart, David I.
    University of Oxford, UK ; Harwell Science and Innovation Campus, UK.
    Structure of Ljungan virus provides insight into genome packaging of this picornavirus2015In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 6, article id 8316Article in journal (Refereed)
    Abstract [en]

    Picornaviruses are responsible for a range of human and animal diseases, but how their RNA genome is packaged remains poorly understood. A particularly poorly studied group within this family are those that lack the internal coat protein, VP4. Here we report the atomic structure of one such virus, Ljungan virus, the type member of the genus Parechovirus B, which has been linked to diabetes and myocarditis in humans. The 3.78-angstrom resolution cryo-electron microscopy structure shows remarkable features, including an extended VP1 C terminus, forming a major protuberance on the outer surface of the virus, and a basic motif at the N terminus of VP3, binding to which orders some 12% of the viral genome. This apparently charge-driven RNA attachment suggests that this branch of the picornaviruses uses a different mechanism of genome encapsidation, perhaps explored early in the evolution of picornaviruses.

  • 1179655. Zhu, Liping
    et al.
    Zhen, Xiaolin
    Wang, Junbo
    Lü, Houyuan
    Xie, Manping
    Kitagawa, Hiroyki
    Possnert, Göran
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Ion Physics.
    A similar to 30,000-year record of environmental changes inferred from Lake Chen Co, Southern Tibet2009In: Journal of Paleolimnology, ISSN 0921-2728, E-ISSN 1573-0417, Vol. 42, no 3, p. 343-358Article in journal (Refereed)
    Abstract [en]

    Climatic and environmental changes since the last glacial period are important to our understanding of global environmental change. There   are few records from Southern Tibet, one of the most climatically   sensitive areas on earth. Here we present a study of the lake sediments   (TC1 core) from Lake Chen Co, Southern Tibet. Two sediment cores were   drilled using a hydraulic borer in Terrace 1 of Lake Chen Co. AMS C-14   dating of the sediments showed that the sequence spanned > 30,000   years. Analyses of present lake hydrology indicated that glacier melt   water is very important to maintaining the lake level. Sediment   variables such as grain size, TOC, TN, C/N, Fe/Mn, CaCO3, and pollen   were analyzed. Warm and moderately humid conditions dominated during   the interval 30,000-26,500 cal year BP. From 26,500 to 20,000 cal year   BP, chemical variables and pollen assemblages indicate a cold/dry   environment, and pollen amounts and assemblages suggest a decline in   vegetation. From 20,000 to 18,000 cal year BP, the environment shifted   from cold/dry to warm/humid and vegetation rebounded. The environment   transitioned to cold/humid during 16,500-10,500 cal year BP, with a   cold/dry event around 14,500 cal year BP. After 10,500 cal year BP, the   environment in this region tended to be warm/dry, but exhibited three   stages. From 10,500 to 9,000 cal year BP, there was a short warm/humid   period, but a shift to cold/dry conditions occurred around 9,000 cal   year BP. Thereafter, from 9,000 to 6,000 cal year BP, there was a   change from cold/dry to warm/humid conditions, with the warmest period   around 6,000 cal year BP. After 6,000 cal year BP, the environment   cooled rapidly, but then displayed a warming trend. Chemical variables   indicate that a relatively warm/dry event occurred around 5,500-5,000   cal year BP, which is supported by time-lagged pollen assemblages   around 4,800 cal year BP. Our lake sediment sequence exhibits   environmental changes since 30,000 cal year BP, and most features agree   with records from the Greenland GISP2 ice core and with other sequences   from the Tibetan Plateau. This indicates that environmental changes   inferred from Lake Chen Co, Southern Tibet were globally significant.

  • 1179656.
    Zhu, Li-wei
    et al.
    Research Institute Of Highway, Ministry of Transport, China.
    Zhang, Zhi-yong
    Research Institute Of Highway, Ministry of Transport, China.
    Fault Diagnosis On The Highway Surveillance And Control System Based On Petri Net Model2013In: Proceedings of the 16th International Conference Road Safety on Four Continents: Beijing, China. 15-17 May 2013, Linköping: Statens väg- och transportforskningsinstitut, 2013Conference paper (Other academic)
    Abstract [en]

    Highway Surveillance and Control System (HSCS) is the critical system to improving the traffic safety and efficiency of highway. In this paper, the fault diagnosis model of HSCS based on Petri Net Model is provided in line with the composition, fault types and features of HSCS, and subsequently the fault diagnostic algorithm is given. In the end of this paper, the fault diagnosis of Microwave Vehicle Detector (MVD) in HSCS is presented to verifying the proposed fault diagnosis model and algorithm.

  • 1179657. Zhu, M
    et al.
    Ahlberg, Per E
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Faculty of Science and Technology, Biology, Department of Physiology and Developmental Biology. Evolutionär organismbiologi.
    The origin of the internal nostril of tetrapods2004In: Nature, Vol. 432, p. 94-97Article in journal (Other scientific)
  • 1179658. Zhu, M.
    et al.
    Ahlberg, Per E.
    Natural History Museum of London .
    Zhao, W.
    Jia , L.
    First Devonian tetrapod from Asia2002In: Nature, ISSN 0028-0836, E-ISSN 1476-4687, Vol. 420, p. 760-761Article in journal (Refereed)
  • 1179659. Zhu, M. -M
    et al.
    Zhao, P. -H
    Chen, Y. -L
    Bai, X. -S
    Fuchs, Laszlo
    KTH, School of Engineering Sciences (SCI), Mechanics.
    The vorticity field of acoustic modulated free jets2012In: Kung Cheng Je Wu Li Hsueh Pao/Journal of Engineering Thermophysics, ISSN 0253-231X, Vol. 33, no 10, p. 1811-1814Article in journal (Refereed)
    Abstract [en]

    The motivation of this paper is to investigate the effects of acoustic modulation on the structures of free jet. Large eddy simulation is performed on three dimensional free jet of Re number 2200 with multigrid method. Comparisons of the vorticity fields are made between the unmodulated jet and perturbed jets with different modulation frequencies. When the modulation frequency is near the preferred mode of the natural jet, the flow field changes significantly. The azimuthal vorticity rolls up into large vortex rings, and the jet spreads more widely. When the modulation frequency is about the twice of the preferred mode, vortex pairing happens and the subharmonic wave becomes dominant. The flow fields are almost the same as the natural jet when the modula-tion frequency is much higher than the preferred mode. The distribution of streamwise vorticity is examined for the modulated jet near the preferred mode, and agrees qualitatively with the experiments.

  • 1179660. Zhu, M. Y.
    et al.
    Sichen, Du
    KTH, Superseded Departments, Materials Science and Engineering.
    Modelling study of slag foaming phenomenon2000In: Steel research, ISSN 0177-4832, Vol. 71, no 3, p. 76-82Article in journal (Refereed)
    Abstract [en]

    A one-dimensional model based on mass and momentum conservations has been developed to predict the heights of foams caused by gas injection. In the development of the model, a dimensionless number, N-foam = u(s)[(3C(d))/(4d(b)g)](1/2) has been deduced to characterise the foaming behaviour. According to the model, an increase in this dimensionless number results in an increase In foaming height. The validity of the model has been experimentally examined using silicon oils. The experiments have also shown that foamings can be classified into two types, namely one-layer foaming and two-layer foaming. The former type results in much larger height than the latter.

  • 1179661. Zhu, M.
    et al.
    Yu, X.
    Ahlberg, Per E.
    Natural History Museum of London .
    A primitive sarcopterygian fish with an eyestalk.2001In: Nature, ISSN 0028-0836, E-ISSN 1476-4687, Vol. 410, p. 81-84Article in journal (Refereed)
  • 1179662.
    Zhu, Miaomiao
    Örebro University, Swedish Business School at Örebro University.
    Is East Asian economy more dependent on exports?: A panel data approach2008Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
  • 1179663.
    Zhu, Min
    Blekinge Institute of Technology, School of Planning and Media Design.
    Research and Application on Typology in the Historical District Renewal2011Independent thesis Advanced level (degree of Master (Two Years))Student thesis
    Abstract [en]

    As an important constituent part during the urban development, the historical district has very important historical and cultural values. At present, with the accelerate development of the whole city, the problem of how to preserve the historical environment and continue the historical essence while make the district adapt to the modern society at the same time became more and more seriously. Therefore, the topic about historical district renewal is well worth researching. This paper starts with issues standing in front of the historical district in the background of quick city booming and then points out the most important problem during the renewal process of historical district in China. After that, this paper introduces typology as a new perspective to solve the problem. The main theories and application methods are both researched in this paper. Based on the sum-up experiences from the example studies, the paper tries to research the concrete process of historical district renewal by using typology as tools, which is mainly from classification, type abstraction and construction to type embodiment. And some basic ways of typology application would be summarized after the case study. These theoretical tools and example experiences are all taken into the case study for practice.

  • 1179664. Zhu, Min
    et al.
    Ahlberg, Per E.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Physiology and Developmental Biology, Evolutionary Organism Biology.
    The origin of the internal nostril of tetrapods2004In: Nature, ISSN 0028-0836, E-ISSN 1476-4687, Vol. 432, no 7013, p. 94-97Article in journal (Refereed)
  • 1179665.
    Zhu, Min
    et al.
    Chinese Acad Sci, Inst Vertebrate Paleontol & Paleoanthropol, Key Lab Vertebrate Evolut & Human Origins, POB 643, Beijing 100044, Peoples R China.;Univ Chinese Acad Sci, Coll Earth Sci, Beijing 100049, Peoples R China..
    Ahlberg, Per E.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Evolution and Developmental Biology.
    Pan, Zhaohui
    Chinese Acad Sci, Inst Vertebrate Paleontol & Paleoanthropol, Key Lab Vertebrate Evolut & Human Origins, POB 643, Beijing 100044, Peoples R China.;Univ Chinese Acad Sci, Coll Earth Sci, Beijing 100049, Peoples R China..
    Zhu, Youan
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Evolution and Developmental Biology.
    Qiao, Tuo
    Chinese Acad Sci, Inst Vertebrate Paleontol & Paleoanthropol, Key Lab Vertebrate Evolut & Human Origins, POB 643, Beijing 100044, Peoples R China..
    Zhao, Wenjin
    Chinese Acad Sci, Inst Vertebrate Paleontol & Paleoanthropol, Key Lab Vertebrate Evolut & Human Origins, POB 643, Beijing 100044, Peoples R China..
    Jia, Liantao
    Chinese Acad Sci, Inst Vertebrate Paleontol & Paleoanthropol, Key Lab Vertebrate Evolut & Human Origins, POB 643, Beijing 100044, Peoples R China..
    Lu, Jing
    Chinese Acad Sci, Inst Vertebrate Paleontol & Paleoanthropol, Key Lab Vertebrate Evolut & Human Origins, POB 643, Beijing 100044, Peoples R China..
    A Silurian maxillate placoderm illuminates jaw evolution2016In: Science, ISSN 0036-8075, E-ISSN 1095-9203, Vol. 354, no 6310, p. 334-336Article in journal (Refereed)
    Abstract [en]

    The discovery of Entelognathus revealed the presence of maxilla, premaxilla, and dentary, supposedly diagnostic osteichthyan bones, in a Silurian placoderm. However, the relationship between these marginal jaw bones and the gnathal plates of conventional placoderms, thought to represent the inner dental arcade, remains uncertain. Here we report a second Silurian maxillate placoderm, which bridges the gnathal and maxillate conditions. We propose that the maxilla, premaxilla, and dentary are homologous to the gnathal plates of placoderms and that all belong to the same dental arcade. The gnathal-maxillate transformation occurred concurrently in upper and lower jaws, predating the addition of infradentary bones to the lower jaw.

  • 1179666.
    Zhu, Min
    et al.
    Chinese Acad Sci, Inst Vertebrate Paleontol & Paleoanthropol, Key Lab Vertebrate Evolut & Human Origins, POB 643, Beijing 100044, Peoples R China.;Univ Chinese Acad Sci, Coll Earth Sci, Beijing 100049, Peoples R China..
    Ahlberg, Per E.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Evolution and Developmental Biology.
    Zhao, Wen-Jin
    Chinese Acad Sci, Inst Vertebrate Paleontol & Paleoanthropol, Key Lab Vertebrate Evolut & Human Origins, POB 643, Beijing 100044, Peoples R China.;Univ Chinese Acad Sci, Coll Earth Sci, Beijing 100049, Peoples R China..
    Jia, Lian-Tao
    Chinese Acad Sci, Inst Vertebrate Paleontol & Paleoanthropol, Key Lab Vertebrate Evolut & Human Origins, POB 643, Beijing 100044, Peoples R China..
    A Devonian tetrapod-like fish reveals substantial parallelism in stem tetrapod evolution2017In: Nature Ecology & Evolution, E-ISSN 2397-334X, Vol. 1, no 10, p. 1470-1476Article in journal (Refereed)
    Abstract [en]

    The fossils assigned to the tetrapod stem group document the evolution of terrestrial vertebrates from lobe-finned fishes. During the past 18 years the phylogenetic structure of this stem group has remained remarkably stable, even when accommodating new discoveries such as the earliest known stem tetrapod Tungsenia and the elpistostegid (fish-tetrapod intermediate) Tiktaalik. Here we present a large lobe-finned fish from the Late Devonian period of China that disrupts this stability. It combines characteristics of rhizodont fishes (supposedly a basal branch in the stem group, distant from tetrapods) with derived elpistostegid-like and tetrapod-like characters. This melange of characters may reflect either detailed convergence between rhizodonts and elpistostegids plus tetrapods, under a phylogenetic scenario deduced from Bayesian inference analysis, or a previously unrecognized close relationship between these groups, as supported by maximum parsimony analysis. In either case, the overall result reveals a substantial increase in homoplasy in the tetrapod stem group. It also suggest that ecological diversity and biogeographical provinciality in the tetrapod stem group have been underestimated.

  • 1179667. Zhu, Min
    et al.
    Yu, Xiaobo
    Ahlberg, Per Erik
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Evolution and Developmental Biology.
    Choo, Brian
    Lu, Jing
    Qiao, Tuo
    Qu, Qingming
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Evolution and Developmental Biology.
    Zhao, Wenjin
    Jia, Liantao
    Blom, Henning
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Evolution and Developmental Biology.
    Zhu, You'an
    A Silurian placoderm with osteichthyan-like marginal jaw bones2013In: Nature, ISSN 0028-0836, E-ISSN 1476-4687, Vol. 502, no 7470, p. 188-+Article in journal (Refereed)
    Abstract [en]

    The gnathostome (jawed vertebrate) crown group comprises two extant clades with contrasting character complements. Notably, Chondrichthyes (cartilaginous fish) lack the large dermal bones that characterize Osteichthyes (bony fish and tetrapods). The polarities of these differences, and the morphology of the last common ancestor of crown gnathostomes, are the subject of continuing debate. Here we describe a three-dimensionally preserved 419-million-year-old placoderm fish from the Silurian of China that represents the first stem gnathostome with dermal marginal jaw bones (premaxilla, maxilla and dentary), features previously restricted to Osteichthyes. A phylogenetic analysis places the new form near the top of the gnathostome stem group but does not fully resolve its relationships to other placoderms. The analysis also assigns all acanthodians to the chondrichthyan stem group. These results suggest that the last common ancestor of Chondrichthyes and Osteichthyes had a macromeric dermal skeleton, and provide a new framework for studying crown gnathostome divergence.

  • 1179668. Zhu, Min
    et al.
    Yu, Xiaobo
    Choo, Brian
    Qu, Qingming
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Evolution and Developmental Biology.
    Jia, Liantao
    Zhao, Wenjin
    Qiao, Tuo
    Lu, Jing
    Fossil Fishes from China Provide First Evidence of Dermal Pelvic Girdles in Osteichthyans2012In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 7, no 4, p. e35103-Article in journal (Refereed)
    Abstract [en]

    Background: The pectoral and pelvic girdles support paired fins and limbs, and have transformed significantly in the diversification of gnathostomes or jawed vertebrates (including osteichthyans, chondrichthyans, acanthodians and placoderms). For instance, changes in the pectoral and pelvic girdles accompanied the transition of fins to limbs as some osteichthyans (a clade that contains the vast majority of vertebrates - bony fishes and tetrapods) ventured from aquatic to terrestrial environments. The fossil record shows that the pectoral girdles of early osteichthyans (e. g., Lophosteus, Andreolepis, Psarolepis and Guiyu) retained part of the primitive gnathostome pectoral girdle condition with spines and/or other dermal components. However, very little is known about the condition of the pelvic girdle in the earliest osteichthyans. Living osteichthyans, like chondrichthyans (cartilaginous fishes), have exclusively endoskeletal pelvic girdles, while dermal pelvic girdle components (plates and/or spines) have so far been found only in some extinct placoderms and acanthodians. Consequently, whether the pectoral and pelvic girdles are primitively similar in osteichthyans cannot be adequately evaluated, and phylogeny-based inferences regarding the primitive pelvic girdle condition in osteichthyans cannot be tested against available fossil evidence.

    Methodology/Principal Findings: Here we report the first discovery of spine-bearing dermal pelvic girdles in early osteichthyans, based on a new articulated specimen of Guiyu oneiros from the Late Ludlow (Silurian) Kuanti Formation, Yunnan, as well as a re-examination of the previously described holotype. We also describe disarticulated pelvic girdles of Psarolepis romeri from the Lochkovian (Early Devonian) Xitun Formation, Yunnan, which resemble the previously reported pectoral girdles in having integrated dermal and endoskeletal components with polybasal fin articulation.

    Conclusions/Significance: The new findings reveal hitherto unknown similarity in pectoral and pelvic girdles among early osteichthyans, and provide critical information for studying the evolution of pelvic girdles in osteichthyans and other gnathostomes.

  • 1179669.
    Zhu, Minggu
    et al.
    So Medical University.
    Yuan, Haifeng
    So Medical University.
    Guo, Wen
    So Medical University.
    Li, Xinyan
    So Medical University.
    Jin, Lin
    So Medical University.
    Brunk, Ulf
    Linköping University, Department of Medical and Health Sciences, Pharmacology. Linköping University, Faculty of Health Sciences.
    Han, Jiahuai
    Xiamen University.
    Zhao, Ming
    So Medical University.
    Liu, Yawei
    So Medical University.
    Dietary Mustard Seeds (Sinapis alba Linn) Suppress 1,2-Dimethylhydrazine-Induced Immuno-Imbalance and Colonic Carcinogenesis in Rats2012In: Nutrition and Cancer, ISSN 0163-5581, E-ISSN 1532-7914, Vol. 64, no 3, p. 464-472Article in journal (Refereed)
    Abstract [en]

    In a Wistar rat model, prolonged supplementation of mustard seed (MS) to the diet significantly ameliorates the induction of colorectal carcinomas by 1,2-dimethylhydrazine (DMH). The expression of the splenocyte major histocompatibility complex class I (MHCI) was found significantly enhanced, whereas that of the major histocompatibility complex class II (MHCII) was significantly decreased. Compared to that of control animals, the proportion of spleenic B- and dendritic cells (DC) was amplified in the MS group. The expressions of MHCI, as well as that of MHCII, were increased in DC cells; whereas in B cells, MHCI expression was augmented but that of MHCII moderately decreased. The percentages of CD8+CD28+ and CD4+CD28+ cells were increased in the MS group, while the CD4+CD25+Foxp3+ subset was depressed. Plasma analysis showed that DMH-exposure induced amplified amounts of interleukin (IL)-4, IL-5, IL-10, and transforming growth factor-beta, whereas MS feeding counteracted this effect but enhanced IL-2,IL12p70,IL21, TNF-alpha, and interferon-gamma. In the SW480 colon adenocarcinoma cell-line, the cytotoxicity of spleenic T-cells from MS-fed animals was significantly increased. In the DMH-exposed rats, the expression of perforin in the spleenic T-cells was dramatically decreased, whereas MS abolished this depression. In summary, dietary MS suppresses DMH-induced immuno-imbalance as well as colon carcinogenesis in rats.

  • 1179670.
    Zhu, Mingjie
    et al.
    Växjö University, Faculty of Mathematics/Science/Technology, School of Mathematics and Systems Engineering.
    Liu, Qinghua
    Växjö University, Faculty of Mathematics/Science/Technology, School of Mathematics and Systems Engineering.
    XAP Integration2006Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Abstract

    This bachelor thesis will present the XAP tool integration project. Apart from presenting the survey of

    integration techniques that includes integration models and case tool models, we have conducted a

    comparison of these models. Then we reason about their applicability in the XAP setting. We apply this

    survey into the XAP tool integration project – integrate three tools in one IDE on data level. In this IDE,

    the user can create a new project and use these three tools freely in the new created project. The

    database among them is shared.

  • 1179671.
    Zhu, Mingzhao
    et al.
    Stockholm University, Faculty of Science, Department of Organic Chemistry.
    Jalalian, Nazli
    Stockholm University, Faculty of Science, Department of Organic Chemistry.
    Olofsson, Berit
    Stockholm University, Faculty of Science, Department of Organic Chemistry.
    One-pot synthesis of diaryliodonium salts using toluenesulfonic acid - a fast entry to electron-rich diaryliodonium tosylates and triflates2008In: Synlett: Accounts and Rapid Communications in Synthetic Organic Chemistry, ISSN 0936-5214, E-ISSN 1437-2096, no 4, p. 592-596Article in journal (Refereed)
    Abstract [en]

    A direct synthesis of symmetric and unsymmetric electron-rich diaryliodonium salts is described. The use of MCPBA and toluenesulfonic acid delivers diaryliodonium tosylates in high yields. An in situ anion exchange has also been developed, giving access to the corresponding triflate salts.

  • 1179672.
    Zhu, Mingzhao
    et al.
    Stockholm University, Faculty of Science, Department of Organic Chemistry.
    Lin, Shuangzheng
    Stockholm University, Faculty of Science, Department of Organic Chemistry.
    Zhao, Gui-Ling
    Stockholm University, Faculty of Science, Department of Organic Chemistry.
    Sun, Junliang
    Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK).
    Córdova, Armando
    Stockholm University, Faculty of Science, Department of Organic Chemistry.
    Organocatalytic diastereoselective dibromination of alkenes2010In: Tetrahedron Letters, ISSN 0040-4039, E-ISSN 1359-8562, Vol. 51, no 20, p. 2708-2712Article in journal (Refereed)
    Abstract [en]

    A highly diastereoselective pyrrolidine-promoted dibromination of alkenes by combination of NBS and succinimide is presented. The pyrrolidine-mediated dibromination of alkenes is higly anti-selective and gives the corresponding products in moderate to high yields and up to >25:1 dr.

  • 1179673. Zhu, Mingzhao
    et al.
    Shuangzheng, Lin
    Zhao, Gui-Ling
    Sun, Junliang
    Córdova, Armando
    Mid Sweden University, Faculty of Science, Technology and Media, Department of Natural Sciences, Engineering and Mathematics.
    Organocatalytic diasteroselective dibromination of alkenes2010In: Tetrahedron Letters, ISSN 0040-4039, E-ISSN 1359-8562, Vol. 51, p. 2708-2712Article in journal (Refereed)
    Abstract [en]

    A highly diastereoselective pyrrolidine-promoted dibromination of alkenes by combination of NBS and succinimide is presented. The pyrrolidine-mediated dibromination of alkenes is higly anti-selective and gives the corresponding products in moderate to high yields and up to >25:1 dr.

  • 1179674.
    Zhu, Mingzhu
    et al.
    Peking University, Peoples R China.
    Du, Junbao
    Peking University, Peoples R China; Minist Educ, Peoples R China.
    Chen, Siyao
    Peking University, Peoples R China.
    Dong Liu, Angie
    Holmberg, Lukas
    Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Medicine and Health Sciences.
    Chen, Yonghong
    Peking University, Peoples R China.
    Zhang, Chunyu
    Peking University, Peoples R China.
    Tang, Chaoshu
    Minist Educ, Peoples R China; Peking University, Peoples R China.
    Jin, Hongfang
    Peking University, Peoples R China.
    L-Cystathionine Inhibits the Mitochondria-Mediated Macrophage Apoptosis Induced by Oxidized Low Density Lipoprotein2014In: International Journal of Molecular Sciences, ISSN 1422-0067, E-ISSN 1422-0067, Vol. 15, no 12, p. 23059-23073Article in journal (Refereed)
    Abstract [en]

    This study was designed to investigate the regulatory role of L-cystathionine in human macrophage apoptosis induced by oxidized low density lipoprotein (ox-LDL) and its possible mechanisms. THP-1 cells were induced with phorbol 12-myristate 13-acetate (PMA) and differentiated into macrophages. Macrophages were incubated with ox-LDL after pretreatment with L-cystathionine. Superoxide anion, apoptosis, mitochondrial membrane potential, and mitochondrial permeability transition pore (MPTP) opening were examined. Caspase-9 activities and expression of cleaved caspase-3 were measured. The results showed that compared with control group, ox-LDL treatment significantly promoted superoxide anion generation, release of cytochrome c (cytc) from mitochondrion into cytoplasm, caspase-9 activities, cleavage of caspase-3, and cell apoptosis, in addition to reduced mitochondrial membrane potential as well as increased MPTP opening. However, 0.3 and 1.0 mmol/L L-cystathionine significantly reduced superoxide anion generation, increased mitochondrial membrane potential, and markedly decreased MPTP opening in ox-LDL + L-cystathionine macrophages. Moreover, compared to ox-LDL treated-cells, release of cytc from mitochondrion into cytoplasm, caspase-9 activities, cleavage of caspase-3, and apoptosis levels in L-cystathionine pretreated cells were profoundly attenuated. Taken together, our results suggested that L-cystathionine could antagonize mitochondria-mediated human macrophage apoptosis induced by ox-LDL via inhibition of cytc release and caspase activation.

  • 1179675.
    Zhu, Mingzhu
    et al.
    Peking University, Peoples R China.
    Du, Junbao
    Peking University, Peoples R China; Minist Educ, Peoples R China; Peking University, Peoples R China.
    Dong Liu, Angie
    Linköping University, Department of Medical and Health Sciences. Linköping University, Faculty of Medicine and Health Sciences.
    Holmberg, Lukas
    Linköping University, Department of Medical and Health Sciences. Linköping University, Faculty of Medicine and Health Sciences.
    Chen, Selena Y.
    University of Calif San Diego, CA 92093 USA.
    Bu, Dingfang
    Peking University, Peoples R China.
    Tang, Chaoshu
    Minist Educ, Peoples R China; Peking University, Peoples R China.
    Jin, Hongfang
    Peking University, Peoples R China.
    L-cystathionine inhibits oxidized low density lipoprotein-induced THP-1-derived macrophage inflammatory cytokine monocyte chemoattractant protein-1 generation via the NF-kappa B pathway2015In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 5, no 10453Article in journal (Refereed)
    Abstract [en]

    This study aimed to explore whether and how L-cystathionine had any regulatory effect on the inflammatory response in THP-1-derived macrophages cultured in vitro under oxidized low-density lipoprotein (ox-LDL) stimulation. The human monocyte line THP-1 cell was cultured in vitro and differentiated into macrophages after 24 hours of PMA induction. Macrophages were pretreated with L-cystathionine and then treated with ox-LDL. The results showed that compared with the controls, ox-LDL stimulation significantly upregulated the expression of THP-1-derived macrophage MCP-1 by enhancing NF-kappa B p65 phosphorylation, nuclear translocation and DNA binding with the MCP-1 promoter. Compared with the ox-LDL group, 0.3 mmol/L and 1.0 mmol/L L-cystathionine significantly inhibited the expression of THP-1-derived macrophage MCP-1. Mechanistically, 0.3 mmol/L and 1.0 mmol/L L-cystathionine suppressed phosphorylation and nuclear translocation of the NF-kappa B p65 protein, as well as the DNA binding activity and DNA binding level of NF-kappa B with the MCP-1 promoter, which resulted in a reduced THP-1-derived macrophage MCP-1 generation. This study suggests that L-cystathionine could inhibit the expression of MCP-1 in THP-1-derived macrophages induced by ox-LDL via inhibition of NF-kappa B p65 phosphorylation, nuclear translocation, and binding of the MCP-1 promoter sequence after entry into the nucleus.

  • 1179676.
    Zhu, Mingzhu
    et al.
    Peking University of First Hospital, Peoples R China .
    Du, Junbao
    Peking University of First Hospital, Peoples R China Minist Educ, Peoples R China .
    Dong Liu, Angie
    Linköping University, Department of Medical and Health Sciences. Linköping University, Faculty of Health Sciences.
    Holmberg, Lukas
    Linköping University, Department of Medical and Health Sciences. Linköping University, Faculty of Health Sciences.
    Tang, Chaoshu
    Minist Educ, Peoples R China Peking University, Peoples R China .
    Jin, Hongfang
    Peking University of First Hospital, Peoples R China .
    Effect of endogenous sulfur dioxide in regulating cardiovascular oxidative stress2014In: Histology and Histopathology, ISSN 0213-3911, E-ISSN 1699-5848, Vol. 29, no 9, p. 1107-1111Article, review/survey (Refereed)
    Abstract [en]

    In the middle of the 1980s, nitric oxide received extensive attention because of its significant effects in life science. Then, carbon monoxide and hydrogen sulfide were discovered to be gasotransmitters playing important roles in regulating cellular homeostasis. As a common air pollutant, sulfur dioxide (SO2) can cause great harm to the human body by producing free radicals, which causes oxidative damage to various organs. Recently, endogenous SO2 was found to be produced in the cardiovascular system and might be a bioactive molecule regulating the physiological activities including cardiovascular oxidative stress.

  • 1179677.
    Zhu, Minpeng
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Division of Computing Science. Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Computing Science.
    Scalable Queries over Log Database Collections2016Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    In industrial settings, machines such as trucks, hydraulic pumps, etc. are widely distributed at different geographic locations where sensors on machines produce large volumes of data. The data produced is stored locally in autonomous databases called log databases. The collection of log databases is dynamically changing when new sites are dynamically added or removed from the federation.

    In this application context, an efficient way to search and analyze passed behavior of products in use is desired. To enable scalable queries over collections of distributed and autonomous log databases we developed the FLOQ (Fused LOg database Query processor) system, which provides a global view of the working status of all machines on the sites through a meta-database integrating the dynamic log database collection. A particular challenge in this scenario is a scalable way to process numerical queries that identify anomalies by joining data from the meta-database with data selected from the collection of distributed and autonomous log databases. The Thesis describes the architecture of FLOQ. In particular different strategies to execute numerical queries over log database collections are investigated. FLOQ allows both the meta-database and the log databases to be stored in multiple formats using different kinds of data managers. FLOQ provides general and extensible mechanisms for efficient processing of queries over different kinds of distributed data sources.

  • 1179678.
    Zhu, Minpeng
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Computing Science.
    Mahmood, Khalid
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Computing Science.
    Risch, Tore
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Computing Science.
    Scalable queries over log database collections2015In: Data Science, Springer, 2015, p. 173-185Conference paper (Refereed)
  • 1179679. Zhu, Minpeng
    et al.
    Risch, Tore
    Querying Combined Cloud-Based and Relational Databases2011Conference paper (Refereed)
    Abstract [en]

    An increasing amount of data is stored in cloud repositories, which provide high availability, accessibility, and scalability. However, for security reasons enterprises often need to store the core proprietary data in their own relational databases, while common data to be widely available can be stored in a cloud data repository. For example, the subsidiaries of a global enterprise are located in different geographic places where each subsidiary is likely to maintain its own local database. In such a scenario, data integration among the local databases and the cloud-based data is inevitable. We have developed a system called BigIntegrator to enable general queries that combine data in cloud-based data stores with relational databases. We present the design and working principle of the system. A scenario of querying data from both kinds of data sources is used as illustration. The system is general and extensible to integrate data from different kinds of data sources. A particular challenge being addressed is the limited query capabilities of cloud data stores. BigIntegrator utilizes knowledge of those limitations to produce efficient query execution.

  • 1179680. Zhu, Minpeng
    et al.
    Stefanova, Silvia
    Truong, Thanh
    Risch, Tore
    Scalable Numerical SPARQL Queries over Relational Databases2014Conference paper (Refereed)
    Abstract [en]

    We present an approach for scalable processing of SPARQL queries to RDF views of numerical data stored in relational databases (RDBs). Such queries include numerical expressions, inequalities, comparisons, etc. inside FILTERs. We call such FILTERs numerical expressions and the queries - numerical SPARQL queries. For scalable execution of numerical SPARQL queries over RDBs, numerical operators should be pushed into SQL rather than executing the filters as post-processing outside the RDB; otherwise the query execution is slowed down, since a lot of data is transported from the RDB server and furthermore indexes on the server are not utilized. The NUMTranslator algorithm converts numerical expressions in numerical SPARQL queries into corresponding SQL expressions. We show that NUMTranslator improves substantially the scalability of SPARQL queries based on a benchmark that analyses numerical logs stored in an RDB. We compared the performance of our approach with the performance of other systems processing SPARQL queries to RDF views of RDBs and show that NUMTranslator improves substantially the scalability of numerical queries compared to the other systems’ approaches.

  • 1179681.
    Zhu, Minying
    Örebro University, Örebro University School of Business.
    Calibration and the two stage Heckman procedure2012Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    The calibration approach is a very general approach to reduce the sampling error and the nonresponse error in sample surveys. Nonresponse in sample surveys can be considered as a kind of sample selection problem. In the econometric literature, the Heckman two-stage procedure is suggested for handling sample selection problem in regression analysis. In this study, we mainly describe the calibration approach, the GREG estimator and the Heckman two-stage model. On the basis of the calibration techniques, we make use of the GREG estimator and the Heckman two-stage procedure to deal with the nonresponse problem, respectively. Via a simulation study, the two kinds of estimators are compared with each other, regarding variance and bias, and ratio of MSE.

  • 1179682. Zhu, M-Y
    et al.
    Jones, T
    Sichen, Du
    KTH, School of Industrial Engineering and Management (ITM), Materials Science and Engineering, Micro-Modelling.
    Modelling study of slag foaming by chemical reactio2001In: Scandinavian journal of metallurgy, ISSN 0371-0459, E-ISSN 1600-0692, Vol. 30, p. 51-56Article in journal (Refereed)
  • 1179683.
    Zhu, Nali
    et al.
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
    Li, An
    School of Public Health, University of Illinois at Chicago, Chicago, United States.
    Wang, Thanh
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
    Wang, Pu
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
    Qu, Guangbo
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
    Ruan, Ting
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
    Fu, Jianjie
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
    Yuan, Bo
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
    Zeng, Lixi
    Graduate University of Chinese Academy of Sciences, Beijing, China.
    Wang, Yawei
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
    Jiang, Guibin
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
    Tris(2,3-dibromopropyl) isocyanurate, hexabromocyclododecanes, and polybrominated diphenyl ethers in mollusks from Chinese Bohai Sea.2012In: Environmental Science and Technology, ISSN 0013-936X, E-ISSN 1520-5851, Vol. 46, no 13, p. 7174-7181Article in journal (Refereed)
    Abstract [en]

    A novel brominated flame retardant (BFR), tris(2,3-dibromopropyl) isocyanurate (TBC), as well as hexabromocyclododecanes (HBCDs) and polybrominated diphenyl ethers (PBDEs), were analyzed in 11 species of mollusks collected from nine coastal cities around the Chinese Bohai Sea in 2009 and 2010. The detection frequencies were 100%, 99%, and 77% for PBDEs, HBCDs, and TBC, respectively. Concentrations of ∑HBCDs ranged from below detection limit (nd) to 28.8 ng g(-1) on a dry weight (dw) basis, followed by ∑(12)PBDE (0.01-20.4 ng g(-1) dw) and TBC (nd-12.1 ng g(-1) dw). Statistically significant linear correlations were found among the three BFRs. Positive correlations were found between BFRs concentrations and lipid content in mollusks. The concentrations tend to decrease with increasing trophic levels of the mollusks, implying trophic dilution rather than biomagnifications of the BFRs in the aquatic food chains of the sampling area. Among the 11 mollusks species, Mytilus edulis showed higher bioaccumulation capability than others and was therefore considered to be an appropriate bioindicator of contamination by the BFRs in the Chinese Bohai Sea, in agreement with its previous selection for the biomonitoring of organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs). A dramatic decrease in PBDE concentrations in mollusks of the area was found for the time period from 2003 to 2010, with a half-life of only 2.3 ± 1.7 years, reflecting a rapid response of mollusks to the change in pollution of the marine environment.

  • 1179684.
    Zhu, Nali
    et al.
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
    Schramm, Karl-Werner
    Molecular EXposomics (MEX), Helmholtz Zentrum München Center for Environmental Health, Germany; Wissenschaftszentrum Weihenstephan für Ernährung, Landnutzung und Umwelt, Department für Biowissenschaften, Technical University of Munich (TUM), Freising, Germany.
    Wang, Thanh
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
    Henkelmann, Bernhard
    Molecular EXposomics (MEX), Helmholtz Zentrum München Center for Environmental Health, Germany.
    Fu, Jianjie
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
    Gao, Yan
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
    Wang, Yawei
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China; Molecular EXposomics (MEX), Helmholtz Zentrum München Center for Environmental Health, Germany.
    Jiang, Guibin
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
    Lichen, moss and soil in resolving the occurrence of semi-volatile organic compounds on the southeastern Tibetan Plateau, China2015In: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 518, p. 328-336Article in journal (Refereed)
    Abstract [en]

    This study investigated a wide range of semi-volatile organic compounds (SVOCs), including 28 persistent organochlorine pesticides (OCPs), 18 polychlorinated biphenyls (PCBs), 13 polybrominated diphenyl ethers (PBDEs), and 3 hexabromocyclododecane (HBCD) congeners in lichen, moss and soil collected from the southeastern Tibetan Plateau, China. This allows research provides insight into elevation gradient distributions and possible cold trapping effects of SVOCs in this high mountain area, and compares lichens and mosses as air passive samplers for indicating SVOC occurrences. DDTs, endosulfans, HCHs and hexachlorobenzene predominated in all of the samples. Source analysis indicted that there were fresh inputs of DDTs and HCHs in the sampling region. Lichens and mosses shared commonalities in revealing the profiles and levels of SVOCs based on their lipid-content-normalized concentrations. The concentrations of 12 OCPs and 14 PCBs in lichens were significantly linearly correlated with altitudes, whereas the correlations for mosses and soil with altitudes were insignificant. Both a frequency distribution diagram and the Mountain Contamination Potential Model indicated that SVOCs with specific values of log K-OA (8-11) and log K-WA (2-4) had relative high mountain contamination potential on the Tibetan Plateau.

  • 1179685.
    Zhu, Nali
    et al.
    Research Center for Eco-Environmental Sciences, State Key Laboratory of Environmental Chemistry and Ecotoxicology, Chinese Academy of Sciences, Beijing, Peoples R. China.
    Schramm, Karl-Werner
    Mol EXpos MEX, Deutsches Forschungszentrum für Gesundheit und UmweltMol EXpos MEX, Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), Neuherberg, Germany; Weihenstephan für Ernährung und Landnutzung, Department für Biowissenschaften, Wissenschaftszentrum, Technische Universität München, Freising, Germany.
    Wang, Thanh
    Research Center for Eco-Environmental Sciences, State Key Laboratory of Environmental Chemistry and Ecotoxicology, Chinese Academy of Sciences, Beijing, Peoples R. China.
    Henkelmann, Bernhard
    Mol EXpos MEX, Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), Neuherberg, Germany.
    Zheng, Xiaoyan
    Research Center for Eco-Environmental Sciences, State Key Laboratory of Environmental Chemistry and Ecotoxicology, Chinese Academy of Sciences, Beijing, Peoples R. China; China National Environmental Monitoring Center, Beijing, Peoples R. China.
    Fu, Jianjie
    Research Center for Eco-Environmental Sciences, State Key Laboratory of Environmental Chemistry and Ecotoxicology, Chinese Academy of Sciences, Beijing, Peoples R. China.
    Gao, Yan
    Research Center for Eco-Environmental Sciences, State Key Laboratory of Environmental Chemistry and Ecotoxicology, Chinese Academy of Sciences, Beijing, Peoples R. China.
    Wang, Yawei
    Research Center for Eco-Environmental Sciences, State Key Laboratory of Environmental Chemistry and Ecotoxicology, Chinese Academy of Sciences, Beijing, Peoples R. China; Mol EXpos MEX, Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), Neuherberg, Germany.
    Jiang, Guibin
    Research Center for Eco-Environmental Sciences, State Key Laboratory of Environmental Chemistry and Ecotoxicology, Chinese Academy of Sciences, Beijing, Peoples R. China.
    Environmental fate and behavior of persistent organic pollutants in Shergyla Mountain, southeast of the Tibetan Plateau of China2014In: Environmental Pollution, ISSN 0269-7491, E-ISSN 1873-6424, Vol. 191, p. 166-174Article in journal (Refereed)
    Abstract [en]

    Pristine mountains are ideal settings to study transport and behavior of persistent organic pollutants (POPs) along gradients of climate and land cover. The present work investigated the concentrations and patterns of 28 organochlorine pesticides (OCPs), 25 polychlorinated biphenyl (PCBs), 13 polybrominated diphenyl ethers (PBDEs), and 3 hexabromocyclododecane (HBCDs) isomers in the air of the Shergyla Mountain, southeastern Tibetan Plateau. Endosulfan І, hexachlorobenzene, pentachlorobenzene, hexachlorocyclohexanes and dichlorodibenzotrichloroethane and its degradation products (DDTs) were the predominant compounds while PBDEs and HBCDs showed the lowest background concentrations. Most of the target POPs had significantly higher concentrations in summer than those in winter. Increasing trends of the concentrations of DDTs and endosulfan were found with increasing altitude on the western slope in the Shergyla Mountain. Potential forest filter effect was observed based on the lower air concentrations of the target POPs in the forest than the ones out of the forest.

  • 1179686.
    Zhu, Nanhao
    et al.
    CETC Group, GCI Science and Technology Co.
    Vasilakos, Athanasios
    Luleå University of Technology, Department of Computer Science, Electrical and Space Engineering, Computer Science.
    A generic framework for energy evaluation on wireless sensor networks2016In: Wireless networks, ISSN 1022-0038, E-ISSN 1572-8196, Vol. 22, no 4, p. 1199-1220Article in journal (Refereed)
    Abstract [en]

    Due to reliance on batteries, energy consumption has always been of significant concern for sensor node networks. This work presents the design and implementation of a house-build experimental platform, named Energy Management System for Wireless Sensor Networks (EMrise) for the energy management and exploration on wireless sensor networks. Consisting of three parts, the SystemC-based simulation environment of EMrise enables the HW/SW co-simulation for energy evaluation on heterogeneous sensor networks. The hardware platform of EMrise is further designed to facilitate the realistic energy consumption measurement and calibration as well as accurate energy exploration. In the meantime, a generic genetic algorithm based optimization framework of EMrise is also implemented to automatically, quickly and intelligently fine tune hundreds of possible solutions for the given task to find the best suitable energy-aware tradeoffs

  • 1179687.
    Zhu, Nanhao
    et al.
    CETC Group, GCI Science and Technology Co.
    Vasilakos, Athanasios
    Luleå University of Technology, Department of Computer Science, Electrical and Space Engineering, Computer Science.
    EMrise: An Energy Management Platform for WSNs/WBANs2016In: Energy Management in Wireless Cellular and Ad-hoc Networks, Encyclopedia of Global Archaeology/Springer Verlag, 2016, p. 367-395Chapter in book (Refereed)
    Abstract [en]

    Due to reliance on batteries, energy consumption has always been of significant concern for sensor node networks. This work presents the design and implementation of a house-build experimental platform, named EMrise (Energy Management System for Wireless Sensor Networks) for the energy management and exploration on wireless sensor networks. Consisting of three parts, the SystemC-based simulation environment of EMrise enables the HW/SW co-simulation for energy evaluation on heterogeneous sensor networks. The hardware platform of EMrise is further designed to facilitate the realistic energy consumption measurement and calibration as well as accurate energy exploration. In the meantime, a generic GA (genetic algorithm) based optimization framework of EMrise is also implemented to automatically, quickly and intelligently fine tune hundreds of possible solutions for the given task to find the best suitable energy-aware tradeoffs.

  • 1179688.
    Zhu, Ning
    KTH, School of Information and Communication Technology (ICT), Microelectronics and Applied Physics, MAP.
    Design, Fabrication and Characterization of Planar Lightwave Circuits Based on Silicon Nanowire Platform2009Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Optical devices based on Planar Lightwave Circuit (PLC) technology have well been studied due to their inherited advantages from Integrated Circuits (IC), such as: small size, high reliability, mass production and potential integration with microelectronics. Among all the materials, silicon nanowire platform gains more and more interest. The large refractive index difference between core and cladding allows tremendous reduction of the component size. This thesis studies theoretically and experimentally some integrated optical devices based on silicon nanophotonic platform, including echelle grating demultiplexers and photonic crystals.

    Some of the numerical methods are introduced first. Scalar integral diffraction method is efficient for calculating the diffraction efficiency of gratings. Beam propagation method and finite-difference time-domain method are also introduced, for simulating the light propagation along the devices.

    The fabrication technology and characterization methods are described. The fabrication steps involve: plasma assisted film deposition, E-beam lithography, RIE-etching. All these steps are proceeded under cleanroom environment. The characterization is mainly based on two methods: end-fire coupling and vertical grating coupling. The grating coupler is more efficient compared with the butt-coupling between fiber and nanowires, but is worse solution for final packaging.

    Two types of components have been realized and characterized with the above technology. The echelle grating demultiplexer is one of the key components in WDM networks. A method for increasing the diffraction efficiency based on total internal reflection is applied, and a significant improvement of the diffraction efficiency of more than 3dB is achieved. A novel cross-order echelle grating-based triplexer, a bidirectional transceiver for application in the Passive Optical Networks (PON), has been designed and fabricated, which can multi/demultiplex three channels located at 1310nm, 1490nm and 1550nm. Polarization dependence issue of echelle grating demultiplexers has been studied. Two polarization compensation schemes have been proposed, which are for the first time polarization insensitive designs of echelle grating demultiplexers based on silicon nanowire platform.

    Photonic crystal devices are also addressed in the thesis. There has been little research on the photonic crystal cavity based on pillar type. A silicon pillar type photonic crystal cavity has been fabricated with the measured Q value as high as about 104, and with an extremely high sensitivity for the changing of the background material or the effective diameter of the pillars. This kind of structure has the advantage on sensing applications compared to the air-hole type structure.

  • 1179689.
    Zhu, Ning
    et al.
    KTH, School of Information and Communication Technology (ICT), Centres, Zhejiang-KTH Joint Research Center of Photonics, JORCEP.
    Dai, Daoxin
    KTH, School of Information and Communication Technology (ICT), Centres, Zhejiang-KTH Joint Research Center of Photonics, JORCEP.
    He, Sailing
    KTH, School of Information and Communication Technology (ICT), Centres, Zhejiang-KTH Joint Research Center of Photonics, JORCEP.
    A hybrid modeling for the theoretical analysis of reflections in a multimode-interference coupler based on silicon-on-insulator nanowires2008In: Optics Communications, ISSN 0030-4018, E-ISSN 1873-0310, Vol. 281, no 11, p. 3099-3104Article in journal (Refereed)
    Abstract [en]

    A hybrid method combining the three-dimensional (3D) beam propagation method (BPM) and a 3D finite-difference time-domain (FDTD) method is presented for the simulation of multimode-interference (MMI) couplers based on silicon-on-insulator (SOI) nanowires. This hybrid method makes it possible to have a robust analysis for the reflection properties while avoiding a time-consumed computation with a simplex 3D-FDTD simulation. The reflected power is sensitive to both the length and the width of the MMI coupler and thus one should choose the optimal values for good self-imaging. Furthermore, the reflection could be reduced by introducing tapers between the MMI section and the access waveguides.

  • 1179690.
    Zhu, Ning
    et al.
    E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China.;E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China..
    Li, Xin
    KTH, School of Biotechnology (BIO), Theoretical Chemistry and Biology.
    Wang, Yuan
    Chinese Acad Sci, Key Lab Photochem Convers & Optoelect Mat, Tech Inst Phys & Chem, Beijing 100190, Peoples R China..
    Ma, Xiang
    E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China.;E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China..
    Photo-responsive chiral cyclic molecular switches based on stiff stilbene2016In: Dyes and pigments, ISSN 0143-7208, E-ISSN 1873-3743, Vol. 125, p. 259-265Article in journal (Refereed)
    Abstract [en]

    Two novel photo-responsive chiral cyclic molecular switches constituted of stiff stilbene and binaphthyl moieties connected through alkyl chains of different length were fabricated. The cyclization synthetic strategy employed herein made it convenient to obtain the pure Z isomers rather than Z/E isomer mixtures. The detailed photo-switching behaviors of target compounds were studied by the UV-Vis absorption and circular dichroism spectra in dichloromethane. The twist angles of the binaphthyl of the switches were able to be reversibly modulated by Z/E isomerization of stiff stilbene unit under alternative UV light stimuli and influenced by the length of alkyl chain to some extent.

  • 1179691.
    Zhu, Ning
    et al.
    KTH, School of Information and Communication Technology (ICT), Microelectronics and Applied Physics, MAP. KTH, School of Information and Communication Technology (ICT), Centres, Zhejiang-KTH Joint Research Center of Photonics, JORCEP.
    Song, Jun
    KTH, School of Information and Communication Technology (ICT), Centres, Zhejiang-KTH Joint Research Center of Photonics, JORCEP.
    Wosinski, Lech
    KTH, School of Information and Communication Technology (ICT), Microelectronics and Information Technology, IMIT. KTH, School of Information and Communication Technology (ICT), Centres, Kista Photonics Research Center, KPRC.
    He, Sailing
    KTH, School of Electrical Engineering (EES), Electromagnetic Engineering. KTH, School of Information and Communication Technology (ICT), Centres, Zhejiang-KTH Joint Research Center of Photonics, JORCEP.
    Cross-Order Echelle Grating Triplexer Based on Amorphous Silicon Nanowire Platform2008In: 2008 7TH INTERNATIONAL CONFERENCE ON THE OPTICAL INTERNET (COIN), NEW YORK: IEEE , 2008, p. 37-38Conference paper (Refereed)
    Abstract [en]

    We present fabrication and measurement results of an ultracompact silicon-on-insulator-based echelle-grating triplexer, which uses different diffraction orders to cover a large spectral range from 1.3 mu m to 1.5 mu m, with a footprint of 150 mu m x 200 mu m.

  • 1179692.
    Zhu, Ning
    et al.
    KTH, School of Information and Communication Technology (ICT), Microelectronics and Applied Physics, MAP. KTH, School of Information and Communication Technology (ICT), Centres, Zhejiang-KTH Joint Research Center of Photonics, JORCEP.
    Song, Jun
    KTH, School of Information and Communication Technology (ICT), Microelectronics and Applied Physics, MAP. KTH, School of Information and Communication Technology (ICT), Centres, Zhejiang-KTH Joint Research Center of Photonics, JORCEP.
    Wosinski, Lech
    KTH, School of Information and Communication Technology (ICT), Microelectronics and Applied Physics, MAP. KTH, School of Information and Communication Technology (ICT), Centres, Zhejiang-KTH Joint Research Center of Photonics, JORCEP.
    He, Sailing
    KTH, School of Information and Communication Technology (ICT), Microelectronics and Applied Physics, MAP. KTH, School of Information and Communication Technology (ICT), Centres, Zhejiang-KTH Joint Research Center of Photonics, JORCEP.
    Design of a polarization-insensitive echelle grating demultiplexer based on silicon nanophotonic wires2008In: IEEE Photonics Technology Letters, ISSN 1041-1135, E-ISSN 1941-0174, Vol. 20, no 9-12, p. 860-862Article in journal (Refereed)
    Abstract [en]

    A polarization-insensitive design of an echelle grating (or etched diffraction grating) demultiplexer based on silicon nanowires is proposed in the present letter, by introducing a polarization compensation area in its free propagation region. The polarization-dependent wavelength shift of the present device has been compensated at the whole spectral range. For a design with nine channels and 10-nm channel spacing, when the wavelength shift at the central channel 1550 nm is. completely compensated, the wavelength shifts of the two edge channels are only 0.14 and 0.15 nm, which are acceptable.

  • 1179693.
    Zhu, Ning
    et al.
    KTH, School of Information and Communication Technology (ICT), Microelectronics and Applied Physics, MAP.
    Song, Jun
    KTH, School of Information and Communication Technology (ICT), Microelectronics and Applied Physics, MAP.
    Wosinski, Lech
    KTH, School of Information and Communication Technology (ICT), Microelectronics and Applied Physics, MAP.
    He, Sailing
    KTH, School of Information and Communication Technology (ICT), Microelectronics and Applied Physics, MAP.
    Etched diffraction grating demultiplexers based on amorphous silicon nanowire platform2008In: 2008 Asia Optical Fiber Communication and Optoelectronic Exposition and Conference, AOE 2008, 2008Conference paper (Refereed)
    Abstract [en]

    We present some theoretical and experimental results of Etched Diffraction Grating demultiplexer based on amorphous silicon nanowire platform, including issues with polarization sensitivity, diffraction efficiency and an application to triplexer.

  • 1179694.
    Zhu, Ning
    et al.
    KTH, School of Information and Communication Technology (ICT), Microelectronics and Applied Physics, MAP.
    Song, Jun
    KTH, School of Information and Communication Technology (ICT), Microelectronics and Applied Physics, MAP.
    Wosinski, Lech
    KTH, School of Information and Communication Technology (ICT), Centres, Kista Photonics Research Center, KPRC.
    He, Sailing
    KTH, School of Electrical Engineering (EES).
    Total internal reflection type echelle grating demultiplexer based on amorphous silicon nanowire platform2008In: Proceedings of SPIE - The International Society for Optical Engineering, Hangzhou, 2008, Vol. 7134Conference paper (Refereed)
    Abstract [en]

    In this paper we present measurement results of an ultracompact echelle-grating demultiplexer based on silicon-on-insulator nanowire platform, in which we introduced a total internal reflection design of the grating facets to improve the diffraction efficiency. An average increase of the diffraction efficiency with 3.7dB is observed for the 3 channels compared to a normal design.

  • 1179695.
    Zhu, Ning
    et al.
    KTH, School of Information and Communication Technology (ICT), Microelectronics and Applied Physics, MAP.
    Song, Jun
    KTH, School of Information and Communication Technology (ICT), Centres, Kista Photonics Research Center, KPRC.
    Wosinski, Lech
    KTH, School of Information and Communication Technology (ICT), Microelectronics and Applied Physics, MAP.
    He, Sailing
    KTH, School of Electrical Engineering (EES), Electromagnetic Engineering.
    Thylén, Lars
    KTH, School of Information and Communication Technology (ICT), Optics and Photonics.
    Experimental demonstration of a cross-order echelle grating triplexer based on an amorphous silicon nanowire platform2009In: Optics Letters, ISSN 0146-9592, E-ISSN 1539-4794, Vol. 34, no 3, p. 383-385Article in journal (Refereed)
    Abstract [en]

    We present the design, fabrication, and characterization of an ultracompact silicon-on-insulator-based echelle grating triplexer. It is based on the cross-order design, which utilizes different diffraction orders to cover a large spectral range from 1.3 to 1.5 mu m with three channels located at 1310, 1490, and 1550 nm and with a footprint of 150 mu m X 130 mu m.

  • 1179696.
    Zhu, Ning
    et al.
    KTH, School of Information and Communication Technology (ICT), Microelectronics and Applied Physics, MAP. KTH, School of Information and Communication Technology (ICT), Centres, Zhejiang-KTH Joint Research Center of Photonics, JORCEP.
    Wang, Zhechao
    KTH, School of Information and Communication Technology (ICT), Microelectronics and Applied Physics, MAP. KTH, School of Information and Communication Technology (ICT), Centres, Zhejiang-KTH Joint Research Center of Photonics, JORCEP.
    Wosinski, Lech
    KTH, School of Information and Communication Technology (ICT), Microelectronics and Applied Physics, MAP. KTH, School of Information and Communication Technology (ICT), Centres, Zhejiang-KTH Joint Research Center of Photonics, JORCEP.
    He, Sailing
    KTH, School of Information and Communication Technology (ICT), Microelectronics and Applied Physics, MAP.
    Bragg grating-assisted optical triplexer using two silicon nanowire-based directional couplers2009In: 2009 Asia Communications and Photonics Conference and Exhibition, ACP 2009, 2009, p. 5377094-Conference paper (Refereed)
    Abstract [en]

    A triplexer based on silicon nanophotonic wire structure consisting of two Bragg grating-assisted directional couplers is proposed. The device has low loss, low crosstalk, and a footprint of only 210 x40 μm, The 1-dB bandwidth for the three channels located at 1310, 1490 and 1550 nm are 110, 20, and 20 nm, respectively.

  • 1179697.
    Zhu, Peter
    Linköping University, Department of Science and Technology.
    Deblurring Algorithms for Out-of-focus Infrared Images2010Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    An image that has been subject to the out-of-focus phenomenon has reducedsharpness, contrast and level of detail depending on the amount of defocus. Torestore out-of-focused images is a complex task due to the information loss thatoccurs. However there exist many restoration algorithms that attempt to revertthis defocus by estimating a noise model and utilizing the point spread function.The purpose of this thesis, proposed by FLIR Systems, was to find a robustalgorithm that can restore focus and from the customer’s perspective be userfriendly. The thesis includes three implemented algorithms that have been com-pared to MATLABs built-in. Three image series were used to evaluate the limitsand performance of each algorithm, based on deblurring quality, implementationcomplexity, computation time and usability.Results show that the Alternating Direction Method for total variation de-convolution proposed by Tao et al. [29] together with its the modified discretecosines transform version restores the defocused images with the highest qual-ity. These two algorithms include features such as, fast computational time, fewparameters to tune and a powerful noise reduction.

  • 1179698.
    Zhu, Q.
    et al.
    Laboratory of Physics and Nanostructures, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland.
    Ganière, J. D.
    Laboratory of Quantum Optoelectronics, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland.
    He, Z. B.
    Laboratory of Physics and Nanostructures, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland.
    Karlsson, K Fredrik
    Laboratory of Physics and Nanostructures, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland.
    Byszewski, M.
    Laboratory of Physics and Nanostructures, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland.
    Pelucchi, E.
    Laboratory of Physics and Nanostructures, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland.
    Rudra, A.
    Laboratory of Physics and Nanostructures, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland.
    Kapon, E.
    Laboratory of Physics and Nanostructures, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland.
    Pyramidal GaAs/AlzGa1-zAs quantum wire/dot systems with controlled heterostructure potential2010In: Phys. Rev. B, Vol. 82, article id 165315Article in journal (Refereed)
    Abstract [en]

    The structural and optical properties of controlled-heterostructure-potential, low-dimensional GaAs/AlGaAs nanostructures self-formed during organometallic chemical vapor deposition in tetrahedral pyramids etched in (111)B-GaAs substrates, are investigated using electron microscopy, cathodoluminescence, photoluminescence (PL), photon correlation spectroscopy, and theoretical modeling. Quantum wires/dots with AlGaAs cores with growth-controlled dimensions are formed, with a system of well-defined, low-dimensional nanostructure barriers around them. Transitions between carrier states confined in the AlGaAs quantum wires and dots are identified in the PL spectra, with features in good agreement with model calculations. Emission of single-photons and bunched-photon pairs is observed using temporal photon correlation spectroscopy. This self-formed nanostructure system provides new ways for shaping low-dimensional quantum structures and their heterostructure environment.

  • 1179699. Zhu, Q.
    et al.
    Karlsson, Fredrik
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Materials Science .
    Byszewski, M.
    Rudra, A.
    Pelucchi, E.
    He, Z.
    Kapon, E.
    Hybridization of electron and hole states in pyramidal quantum dot molecules2008In: The 5th International Conerence on Semiconductor Quantum Dots QD2008,2008, 2008Conference paper (Other academic)
  • 1179700.
    Zhu, Q.
    et al.
    Ecole Polytechnique Fédérale de Lausanne .
    Karlsson, Fredrik
    Ecole Polytechnique Fédérale de Lausanne .
    Pelucchi, E.
    Ecole Polytechnique Fédérale de Lausanne .
    Kapon, E.
    Ecole Polytechnique Fédérale de Lausanne .
    Transition from Two-Dimensional to Three-Dimensional Quantum Confinement in Semiconductor Quantum Wires/Quantum Dots2007In: Nano letters (Print), ISSN 1530-6984, E-ISSN 1530-6992, Vol. 7, no 8, p. 2227-2233Article in journal (Refereed)
    Abstract [en]

    We report the photoluminescence (PL) and polarization-resolved PL characteristics of a novel GaAs/AlGaAs quantum wire/dot semiconductor system, realized by metalorganic vapor-phase epitaxy of site-controlled, self-assembled nanostructures in inverted tetrahedral pyramids. By systematically changing the length of the quantum wires, we implement a continuous transition between the regimes of two-dimensional and three-dimensional quantum confinement. The two main evidences for this transition are observed experimentally and confirmed theoretically: (i) strongly blue-shifted ground-state emission, accompanied by increase separation of ground and excited transition energies; and (ii) change in the orientation of the main axis of linear polarization of the photoluminescence, from parallel to perpendicular with respect to the wire axis. This latter effect, whose origin is shown to be purely due to quantum confinement and valence band mixing, sets in at wire lengths of only 30 nm.

23591235922359323594235952359623597 1179651 - 1179700 of 1209146
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