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  • 1167751.
    Yideti, Tatek Fekadu
    KTH, School of Architecture and the Built Environment (ABE), Transport Science, Highway and Railway Engineering.
    Performance model for unbound grnular materials pavements2012Licentiate thesis, comprehensive summary (Other academic)
    Abstract [en]

    Recently, there has been growing interest on the behaviour of unbound granular material in road base layers. Researchers have studied that the design of a new pavement and prediction of service life need proper characterization of unbound granular materials, which is one of the requirements for a new mechanistic design method in flexible pavement.

    Adequate knowledge of the strength and deformation characteristics of unbound layer in pavements is a prerequisite for proper thickness design, residual life determination, and overall economic optimization of the pavement structure. The current knowledge concerning the granular materials employed in pavement structures is limited. In addition, to date, no general framework has been established to explain satisfactorily the behaviour of unbound granular materials under the complex repeated loading which they experience.

    In this study, a conceptual method, packing theory-based model is introduced; this framework evaluates the stability and performance of granular materials based on their packing arrangement. In the framework two basic aggregate structures named as Primary Structure (PS), and Secondary Structure (SS). The Primary Structure (PS) is a range of interactive grain sizes that forms the network of unbound granular materials. The Secondary Structure (SS) includes granular materials smaller than the primary structure. The Secondary Structures fill the gaps between the particles in the Primary Structure and larger particles essentially float in the skeleton.

    In this particular packing theory-based model; the Primary Structure porosity, the average contact points (coordination number) of Primary Structure, and a new parameter named Disruption Potential are the key parameters that determine whether or not a particular gradation results in a suitable aggregate structure.

    Parameters mentioned above play major role in the aggregate skeleton to perform well in terms of resistance to permanent deformation as well as load carrying capacity (resilient modulus). The skeleton of the materials must be composed of both coarse enough and a limited amount of fine granular materials to effectively resist deformation and carry traffic loads.

  • 1167752.
    Yideti, Tatek Fekadu
    et al.
    KTH, School of Architecture and the Built Environment (ABE), Transport Science, Highway and Railway Engineering.
    Birgisson, Björn
    KTH, School of Architecture and the Built Environment (ABE), Transport Science, Highway and Railway Engineering.
    Jelagin, Denis
    KTH, School of Architecture and the Built Environment (ABE), Transport Science, Highway and Railway Engineering.
    A new moisture distribution model for unbound granular materialsIn: Geotechnique, ISSN 0016-8505, E-ISSN 1751-7656Article in journal (Other academic)
    Abstract [en]

    The presence of waterin the unbound granular materials significantly influences the mechanicalperformance of the material. The ability to estimate the soil watercharacteristic curve (SWCC) is crucial thus to determine the effect themoisture has on the mechanical behaviour of granular materials. In this paper,an analytical moisture distribution model is proposed. A packing theory-based framework to evaluateperformance of unbound granular materials reported previously by the authorsallows identifying the two basic components of the unbound granular materialsskeleton: primary structure (PS) - a range of interactive coarse grain sizes thatforms the main load carrying network in granular materials and secondarystructure (SS) - a range of grain sizes smaller than the PS providing stabilityto the aggregate skeleton. In the new moisture distribution model presented inthis paper, moisture wasconsidered to be stored as meniscus water between SS particles and water thatfilled in small voids.The volume of meniscus water between SS particles and the measured matricsuction values are the two key parameters in the model. In order to validatethe model predicted results are then compared with measuredmatric suction of granite granular materials with different gradations. Theresults showed that the model developed is capable of predicting theexperimentally measured matric suction values for a range of gradations. 

  • 1167753.
    Yideti, Tatek Fekadu
    et al.
    KTH, School of Architecture and the Built Environment (ABE), Transport Science, Highway and Railway Engineering.
    Birgisson, Björn
    KTH, School of Architecture and the Built Environment (ABE), Transport Science, Highway and Railway Engineering.
    Jelagin, Denis
    KTH, School of Architecture and the Built Environment (ABE), Transport Science, Highway and Railway Engineering.
    Influence of aggregate packing structure on California bearing ratio values of unbound granular materials2014In: International Journal on Road Materials and Pavement Design, ISSN 1468-0629, E-ISSN 2164-7402, Vol. 15, no 1, p. 102-113Article in journal (Refereed)
    Abstract [en]

    Over the past several decades, California bearing ratio (CBR) value has been used in many countries for empirical pavement designs and still many countries are using it for unbound granular materials strength measurement and as input to their pavement design chart. Furthermore, CBR value of unbound granular material is frequently correlated with its fundamental mechanical properties such as resilient modulus, which in turn is often used as an input to a mechanistic pavement design procedure. In the present study, the effect the aggregate packing has on the CBR values of unbound materials is investigated. A packing theory-based framework that allows to identify the load-carrying part of the aggregate skeleton is presented. Aggregate packing parameters controlling the CBR performance of the unbound materials are introduced and evaluated with the experimentally measured CBR values of 20 unbound granular materials found in the literature. It is shown that the CBR values of granular materials are to a great extent controlled by the packing characteristics of their load-carrying skeleton.

  • 1167754.
    Yideti, Tatek Fekadu
    et al.
    KTH, School of Architecture and the Built Environment (ABE), Transport Science, Highway and Railway Engineering.
    Birgisson, Björn
    KTH, School of Architecture and the Built Environment (ABE), Transport Science, Highway and Railway Engineering.
    Jelagin, Denis
    KTH, School of Architecture and the Built Environment (ABE), Transport Science, Highway and Railway Engineering.
    Guarin, Alvaro
    KTH, School of Architecture and the Built Environment (ABE), Transport Science, Highway and Railway Engineering.
    Packing theory-based framework for evaluating resilient modulus of unbound granular materials2014In: The international journal of pavement engineering, ISSN 1029-8436, E-ISSN 1477-268X, Vol. 15, no 8, p. 689-697Article in journal (Refereed)
    Abstract [en]

    Enhancing the quality of granular layers is fundamental to optimise the structural performance of the pavements. The objective of this study is to investigate whether previously developed packing theory-based aggregate parameters can evaluate the resilient modulus of unbound granular materials. In this study, 19 differently graded unbound granular materials from two countries (USA and Sweden) were evaluated. This study validated both porosity of primary structure (PS) and contact points per particle (coordination number) as key parameters for evaluating the resilient modulus of unbound granular materials. This study showed that decreasing the PS porosity - higher coordination number - calculated based on the proposed gradation model, yields higher resilient modulus. Good correlation was observed between the proposed packing parameters and resilient modulus of several types of aggregates. The packing theory-based framework successfully recognised granular materials that exhibited poor performance in terms of resilient modulus.

  • 1167755.
    Yideti, Tatek Fekadu
    et al.
    KTH, School of Architecture and the Built Environment (ABE), Transport Science, Highway and Railway Engineering.
    Birgisson, Björn
    KTH, School of Architecture and the Built Environment (ABE), Transport Science, Highway and Railway Engineering.
    Jelagin, Denis
    KTH, School of Architecture and the Built Environment (ABE), Transport Science, Highway and Railway Engineering.
    Guarin, Alvaro
    KTH, School of Architecture and the Built Environment (ABE), Transport Science, Highway and Railway Engineering.
    Packing theory-based framework to evaluate permanent deformation of unbound granular materials2013In: The international journal of pavement engineering, ISSN 1029-8436, E-ISSN 1477-268X, Vol. 14, no 3, p. 309-320Article in journal (Refereed)
    Abstract [en]

    Permanent deformation of unbound granular materials plays an essential role in the long-term performance of a pavement structure. Stability of unbound granular materials is defined by the particle-to-particle contact of the system, the particle size distribution and the packing arrangement. This paper presents a gradation model based on packing theory to evaluate permanent deformation of unbound granular materials. The framework was evaluated by using 10 unbound granular materials from different countries. The disruption potential, which determines the ability of secondary structure (SS) to disrupt the primary structure (PS), is introduced. This study also identified the amount of PS and SS that may eventually be used as a design parameter for permanent deformation of unbound road layers. The evaluation of the model regarding permanent deformation behaviour of granular materials is found to compare favourably with experimental results.

  • 1167756.
    Yideti, Tatek Fekadu
    et al.
    KTH, School of Architecture and the Built Environment (ABE), Transport Science, Highway and Railway Engineering.
    Dawson, Andrew
    The University of Nottingham.
    Birgisson, Björn
    KTH, School of Architecture and the Built Environment (ABE), Transport Science, Highway and Railway Engineering.
    Implementation of Shakedown and Packing theories for Unbound Granular materialsIn: Construction and Building Materials, ISSN 0950-0618, E-ISSN 1879-0526Article in journal (Other academic)
    Abstract [en]

    The shakedown theory is a tool to characterize the state of the structural system of an unbound granular material that is subjected to repeated loading when its response has become resilient in nature and no further accumulation of plastic strain occurs. This paper demonstrates the application of both shakedown and packing theories to characterize permanent deformation behaviour of unbound aggregate materials. Ranges of shakedown phenomenon (Ranges A, B and C) for some selected unbound materials have first been investigated based on their permanent strain responses. The disruption potential (DP) of the primary structure (PS) of the aggregate assemblage has then been determined for each grain size distribution based on a packing theory model. The DP was found to characterize satisfactorily the three types of shakedown ranges. A sensitivity analysis has also been done on DP values by changing the dry density and specific gravity, revealing the importance of these characteristics for shakedown. Further, a finite element analysis was performed to determine the shakedown limit load as a mean stress and a dimensionless shakedown load. The analysis was simulated using the Mohr-coulomb yield criteria for a three-dimensional cylindrical sample. From this study the DP value was found to compare favorably with the predicted mean stress and dimensionless shakedown load.

     

  • 1167757.
    Yideti, Tatek
    et al.
    KTH, School of Architecture and the Built Environment (ABE), Transport Science.
    Jelagin, Denis
    KTH, School of Engineering Sciences (SCI), Solid Mechanics (Dept.), Solid Mechanics (Div.). KTH, School of Architecture and the Built Environment (ABE), Civil and Architectural Engineering, Building Materials.
    Birgisson, Björn
    KTH, School of Architecture and the Built Environment (ABE), Transport Science.
    Moisture Distribution Model to Predict Matric Suction in Unbound Granular Materials as a Function of Fines Content2016In: TRB 95th Annual Meeting Compendium of Papers, 2016Conference paper (Refereed)
    Abstract [en]

    The existence of water in the layers of unbound road aggregates significantly influences the performance of pavement structure. Thus, the ability to estimate volumetric water content and its capillary effect is very important. Several models have been suggested to link the matric suction of unbound materials to their water retention properties. In this paper, an analytical moisture distribution model is proposed by using packing theory-based framework for unbound granular materials. The framework was previously developed by the authors of this paper and identifies two basic components of unbound granular materials skeleton: primary structure (PS) - a range of interactive coarse grain sizes that forms the main load-carrying network in granular materials and secondary structure (SS) - a range of grain sizes smaller than the PS providing stability to the aggregate skeleton. In the new moisture model, water was considered to be stored as both menisci water between SS particles and water that fully filled in very small voids. In order to validate the model, predicted results are compared with measured matric suction of a granite material with different gradations. The results showed that the model is capable of predicting the experimentally measured matric suction values for a range of gradations.

  • 1167758.
    Yien Tan, Hong
    et al.
    University of Malaya, Malaysia.
    Kong Yong, Yean
    University of Malaya, Malaysia.
    Shankar, Esaki M.
    University of Malaya, Malaysia; University of Malaya, Malaysia.
    Paukovics, Geza
    Macfarlane Burnet Institute Medical Research and Public Heatlh, Australia.
    Ellegård, Rada
    Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences.
    Larsson, Marie
    Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences.
    Kamarulzaman, Adeeba
    University of Malaya, Malaysia.
    French, Martyn A.
    University of Western Australia, Australia; Royal Perth Hospital, Australia.
    Crowe, Suzanne M.
    Macfarlane Burnet Institute Medical Research and Public Heatlh, Australia; Alfred Hospital, Australia; Monash University, Australia.
    Aberrant Inflammasome Activation Characterizes Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome2016In: Journal of Immunology, ISSN 0022-1767, E-ISSN 1550-6606, Vol. 196, no 10, p. 4052-4063Article in journal (Refereed)
    Abstract [en]

    Tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) complicates combination antiretroviral therapy (cART) in up to 25% of patients with HIV/TB coinfection. Monocytes and IL-18, a signature cytokine of inflammasome activation, are implicated in TB-IRIS pathogenesis. In this study, we investigated inflammasome activation both pre- and post-cART in TB-IRIS patients. HIV/TB patients exhibited higher proportions of monocytes expressing activated caspase-1 (casp1) pre-cART, compared with HIV patients without TB, and patients who developed TB-IRIS exhibited the greatest increase in casp1 expression. CD64(+) monocytes were a marker of increased casp1 expression. Furthermore, IL-1 beta, another marker of inflammasome activation, was also elevated during TB-IRIS. TB-IRIS patients also exhibited greater upregulation of NLRP3 and AIM2 inflammasome mRNA, compared with controls. Analysis of plasma mitochondrial DNA levels showed that TB-IRIS patients experienced greater cell death, especially pre-cART. Plasma NO levels were lower both pre- and post-cART in TB-IRIS patients, providing evidence of inadequate inflammasome regulation. Plasma IL-18 levels pre-cART correlated inversely with NO levels but positively with monocyte casp1 expression and mitochondrial DNA levels, and expression of IL-18R alpha on CD4(+) T cells and NK cells was higher in TB-IRIS patients, providing evidence that IL-18 is a marker of inflammasome activation. We propose that inflammasome activation in monocytes/macrophages of HIV/TB patients increases with ineffective T cell-dependent activation of monocytes/macrophages, priming them for an excessive inflammatory response after cART is commenced, which is greatest in patients with TB-IRIS.

  • 1167759.
    Yifan, Wang
    et al.
    University of Gävle, Faculty of Engineering and Sustainable Development, Department of Industrial Development, IT and Land Management.
    Yizhang, Huang
    University of Gävle, Faculty of Engineering and Sustainable Development, Department of Building, Energy and Environmental Engineering.
    Urban Wind and Thermal Environment Simulation - A Case Study of Gävle, Sweden2013Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    As urbanization and industrialization progressed during the last decades, Urban Heat Island (UHI) has become a major environmental issue to many cities around the world. The effect of UHI differs from area to area due to varying urban scale, population density, construction of urban surface layer, the level of industrialization and type of climate. Researchers have made great efforts in investigating various approaches to Urban Heat Island studies. Monitoring technologies have been widely used in this field, especially Geographic Information System (GIS) and remote sensing technology. Computational Fluid Dynamics (CFD) simulations are also actively applied in wind engineering, which can provide details of air flow over urban areas. The combined application of these technologies can provide the monitoring and simulation of urban wind corridor and thermal environment that can produce relevant information at a lesser time.A research using GIS, remote sensing technology and CFD simulation was done in this project to obtain a holistic view of the urban thermal environment and wind flow for Gävle City. With GIS and remote sensing the thermal image of the city was presented. The temperature data, which were collected from MODIS satellite were transferred and processed by ArcGIS and Global Mapper. The wind flow above the city was simulated through constructing geometric and mathematical model with OpenFOAM. The outcomes of the modeling and simulation identified that the temperature in the city center could possibly reach 35℃ during summers, which can cause the Urban Heat Island to form. Ventilation was also poorer in the city centre, and neither the river nor the green area in the southwest could help ventilate the city. The study result also suggested that certain sites in the city had relatively high wind flow for urban wind turbines to work.This study had used method of Urban Heat Island study with remote sensing and CFD technologies. The model produced from simulation could also be used to further study Gävle city's thermal and wind environment to produce more accurate results.

  • 1167760.
    Yifan, Zheng
    KTH, School of Engineering Sciences (SCI), Physics.
    Research on a material discrimination method by cosmic ray muon tomography2018Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
  • 1167761.
    Yifang, Ban
    et al.
    KTH, School of Architecture and the Built Environment (ABE), Urban Planning and Environment, Geoinformatics.
    Gong, Peng
    Tsinghua University.
    Gini, Chandra
    Global land cover mapping using earth observation satellite data: recent progresses and challenges2015In: ISPRS journal of photogrammetry and remote sensing (Print), ISSN 0924-2716, E-ISSN 1872-8235, Vol. 103, no 1, p. 1-6Article in journal (Refereed)
  • 1167762.
    Yifei, Li
    et al.
    Halmstad University, School of Information Science, Computer and Electrical Engineering (IDE), Halmstad Embedded and Intelligent Systems Research (EIS).
    Lin, Ge
    Halmstad University, School of Information Science, Computer and Electrical Engineering (IDE), Halmstad Embedded and Intelligent Systems Research (EIS).
    Non-Isotropic Planar Motion Planning for Sailboat Navigation2013Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    The purpose of the thesis was to explore the possibilities of using a Level-Set method to design a time-optimal path planar of a subject to direction-dependent maximum velocities. A promising application for such a planning approach lies in sailboat navigation planning, because of the dynamic ocean waves, current, wind and the characteristics of a sailboat. In the thesis, we developed an IOS application to simulate such scenario as environment properties with wind, static obstacles and the sailboat mapped into direction-dependent velocities in different locations of the environment.  Considering the wind is the main power for the sailboat, a wind speed generation function was created, based on different locations. The Level-Set method is widely used in image processing because of its various advantages, for instance, the ability to deal with topology change and stability. It also can be applied in path planning, in which the process of the Level-Set method can be considered as a continuous wave front propagating with a speed from the start location. A grid-based map was used to represent the environment. While the wave front was crossing the cell on the grid, a time was recorded for every cell, following the negative gradient direction of such crossing time, and then an optimal path could be found. In addition, we used the Narrow Band method to speed up the calculation of processing the level set equation. Finally, this report gives the results of the experiments of static obstacle avoidance, wind effects and smooth path planning.

  • 1167763. Yifei, Shi
    Design and construction of control system for a ball-shaped robot2010Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    The aim of this thesis work is to design and construct a control system for a ball-shaped robot, the Thistle, to meet the dened functional requirements. The control system, which includes two parts: hardware and software, realizes the planned architecture and performs required tasks. In the hardware part, two DC motors are applied as actuators. Additionally, various sensors including encoders, accelerometers, gyros which are used to detect the attitude of the robot and inner status of the robot are investigated carefully. One on board computer (Gumstix Overo Fire) is used as a controller to integrate the functions of actuators and sensors. Then wireless communication between operator and robot is established in order to send some simple test commands to the on board computer by WLAN to prove that every part could work and well coordinate with each other. In addition to this electronics work, mechanical work is also involved. Considering the frangibility of the on board computer, accuracy of the measurement from the sensors and the robustness of the whole system, the method to install components on the robot should be taken into account. In the software part, the development environment for cross complying is built based on OpenEmbedded. In robot, a simple embedded system based on the Gumstix COM is developed under Linux. As the controller of the robot, this on board computer is responsible for receiving data from sensors, send command to actuators and also communicate with the operator through WLAN.

  • 1167764.
    Yifter, Lilly
    Ersta Sköndal Bräcke University College, Department of Health Care Sciences.
    Patienter med aggressivt beteende och en förklaringsmodell om vad som kan trigga igång aggressivitet: En Integrativ litteraturöversikt2017Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Background: The care environment within psychiatric inpatient care has been described to create different emotions and is characterized as a hard environment where patients sometimes are treated against their will and can be exposed to coercive measures and restrictions. Aggressiveness is common at these wards and is considered a problem. There is a knowledge gap when it comes to patients and situations that increase the risk for aggressiveness in the context of psychiatric inpatient care.

    Aim: To identify characteristic features of aggressive patients and to identify aspects that effects situations where threats and violence has occurred in psychiatric inpatient care and to synthesise an explanatory model.

    Method: An integrative literature overview containing both qualitative and quantitative articles. The data were analysed using Whittemore and Knafl’s (2005) working procedure.

    Results: The result generated in three main themes and ten subthemes. Following three main themes were identified: the patient as a trigger, the care environment as a trigger and the staff as a trigger.

    Discussion: The method is discussed in relation to these concepts: trustworthiness, dependability, confirmability and transferability. The results are discussed with support of previous research and in relation to Phil Barker's theory the Tidal model.

  • 1167765.
    Yifter Lindgren, Emanuel
    Umeå University, Faculty of Science and Technology, Department of Computing Science.
    En studie om styrkor och svagheter hos sudokulösande algoritmer2014Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Sudoku is a popular game of logic in the form of a puzzle. Sudoku puzzles are printed daily in Swedish newspapers. The challenge of solving these puzzles have inspired many programmers to develop Sudokusolving algorithms. These algorithms use different approaches in order to quickly and efficiently solve the puzzles. One such approach is the use of logical strategies initially developed for human players. The purpose of this project is to benchmark and compare different approaches and algorithms. The results of the benchmarks is then used to evaluate the strength and weaknesses of each algorithm. The benchmark is performed with 12000 Sudoku puzzles of varying difficulty. The study shows that Dancing Links is the best performing algorithm in general. Dancing Links excels in each comparison criteria, one of which is solving speed. An algorithm that does not impress is Backtracking. The algorithm consistently takes the most time to solve a puzzle. The solving speed of the algorithm also varies greatly depending on the number of clues in the puzzle. This makes the algorithm less suitable for applications were solving speed is of concern. Only the strategy-based algorithm fails to solve all the puzzles. However the algorithm did manage to solve the easier puzzles and is consistently faster than Backtracking. A trend was observed where the algorithm’s speed was negatively affected by an increasing difficulty.

  • 1167766.
    Yigit, Mert
    Blekinge Institute of Technology, School of Management.
    Organizational Ambidexterity: Balancing Exploitation and Exploration in Organizations2013Independent thesis Advanced level (degree of Master (Two Years))Student thesis
    Abstract [en]

    Purpose: This paper aims to investigate necessity of ambidexterity for organizations. The main interest of this thesis is to investigate why organizations should be ambidextrous and how organizations can reach ambidexterity under the pressure of limited resources and competitive market condition. Findings: This thesis explored relations and tensions between exploitation and exploration in organizational and individual aspects. Findings in the research show that communication skill of the subunits in the case company need to be strengthened. Subunits need to be independent from each other. However, they should be aware of other subunits’ actions. In this sense, there is need for strong information flow between all units in the case company. Participation of employees and teamwork should be promoted by leaders. This thesis suggests that establishing special subunits for explorative activities would not only leverage explorative processes in the organizations but it would also leverage exploitative activities. This issue causes time management and scheduling problem for the employees and also individuals are distracted by focusing on conflicting dimensions such as explorative and exploitative tasks. Behavioral integrity is one of the most important subjects. Behavioral integrity is the key factor to provide consistency between subunits. Independent subunits with common vision lead firms to ambidexterity. Implications: The implications of this study contribute to achievement of organizational ambidexterity in companies. This thesis was started with introduction to importance of ambidexterity, organizational ambidexterity, exploration and exploitation in case of long and short term organizational performance in sight of knowledge based and managerial perspective. It also explored relations and tensions between these dimensions such as exploration and exploitation in terms of organizational and individual aspects, contextual and structural ambidexterity, social support and performance management, dynamic and ambidextrous capabilities with implication of case study research.

  • 1167767.
    YIJIA, LI
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Informatics and Media.
    Is social media a fortune or misfortune? —The art film’s dilemma and breakthrough.2018Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    In China, Weibo is a social software that almost everyone uses. Weibo does not only provide an arena for users to share their experiences with friends but also offers a platform for companies to promote their products. From 2014, the distributors of the films began to use Weibo as one of their main marketing tools. Nevertheless, from the same time, Chinese art films have begun to decline, and the most direct manifestation is the downturn in the box office. At the coincidence of the two time points, the decline of art films and the Weibo seems to be linked. However, there are still a handful of art films which achieved great success on Weibo in this 3-year period. In these cases, Weibo seems to be a fortune for these art films. The first part of this study is devoted to exploring what has changed in the ways to Weibo users’ get information and communicate about films, especially art films from 2014 to 2017 by social media logic. The second part analyzes a successful case and tries to find out how the distributors of the art films could use Weibo as an online marketing tool to conduct online marketing activities by combing the social media logic with the marketing strategy for non-mainstream culture products. This study used a combination of qualitative research and quantitative research. After analyzing the collected data, it is indicated that during the three years, Weibo users have changed a lot in obtaining movie information and communicating art movies which might have an impact on Weibo users discussing art films and purchasing tickets. Weibo can also be utilized by art films distributors using idiosyncratic marketing approach than ordinary method to attract audience's attention.

  • 1167768.
    Yijun, Ding
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Informatics and Media.
    The aura of the artwork in the digitalization age: An experimental study based on Benjamin and Baudrillard2017Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    This thesis explores how the aura of the artworks changes in the age of digital reproduction through the empirical experiments conducted in Uppsala Konstmuseum. By employing the definition of the aura given by Benjamin in The work of art in the age of the mechanical reproduction and The arcade project, this thesis conceptualizes the “aura” into eight dimensions and then operationalizes the eight dimensions in order to find whether audience’s evaluation of the artwork changes when they are given different stimulus in the control experiment. From the control experiment, the quantitative data will be obtained from a questionnaire and non-participant observation. The qualitative data will be obtained from the interviews. By also applying the simulacra theory of Baudrillard to the analysis part, this thesis finds that there exists a small difference in the perception of the aura between the people who see a digital copy and who see a real painting. The aura still has its power. However, such power is really weak, as many dimensions of the aura have been weakened by the digital simulacra. Through this study, I suggest the museums to take cautious steps to digitalize their artworks though there is no evidence that virtual museums can replace real museums. 

  • 1167769.
    Yika Tuesta, Alberto Stavros
    KTH, School of Electrical Engineering (EES), Micro and Nanosystems.
    Dielectrophoresis (DEP) and electrowetting (EWOD) as Anti-fouling processes for antibacterial surfaces2014Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Today the medical field is struggling to decrease bacteria biofilm formation which leads to infection. Also, biomedical devices sterilization has not changed over a long period of time which has resulted in high costs for hospitals healthcare managements. The objective of this project is to investigate electro-dynamic effects by surface energy manipulation as potential methods for preventing bacteria biofilm growing on medical devices.

    Based on electrokinetic environments two different methods were tested: rejection bacteria dielectrophoretic forces feasibility by numerical simulations; and electrowetting-on -dielectric by the fabrication of golden interdigitated electrodes on silicon glass substrates covered by a Teflon layer.

    In the first experiment, numerical simulations of gold electrodes in buffer solution and frequencies were carried out to determine the forces required to reject bacteria. In the second experiment, interdigitated gold electrodes coated with a dielectric Teflon layer, were characterized in terms of breakdown voltage, dielectric adhesion and contact angle in terms of applied voltage. Finally the effect of EWOD on bacterial adhesion was tested.

    The project resulted in promising simulation results for bacteria rejection using dielectrophoresis due to the wide range of frequency that rejects the modelled bacteria. However, practical experiments such as electrowetting-on-dielectric must verify this at incubation times larger than 24 hours in spite of the Teflon non-adhesive properties.

  • 1167770.
    Yilda, Sandra
    et al.
    University of Borås, Faculty of Librarianship, Information, Education and IT.
    Yonadam, Nenwi Jeems
    University of Borås, Faculty of Librarianship, Information, Education and IT.
    Högläsning: En intervjustudie om högläsning i förskolan2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Sammanfattning

    I denna studie undersöks högläsning i förskolan utifrån ett pedagogperspektiv. Vi tar vår utgångspunkt i tidigare forskning som visar att högläsning är betydelsefull ur flera aspekter.

    Syftet med detta examensarbete är att undersöka hur pedagogerna planerar och använder sig av högläsning i förskolan samt hur de upplever att högläsningen fungerar. Vi har använt oss utav den kvalitativa metoden och genomfört intervjuer med fem pedagoger om högläsning. Det gav oss möjlighet att ta del av deras olika erfarenheter och lyfta fram dem.

    Resultatet av vår studie visar att de intervjuade pedagogerna har olika syften kring högläsningen på förskolan, som ökat ordförråd, språkutveckling och vila. De har också tankar om att skapa nyfikenhet och bokvana hos barnen. Pedagogerna planerar för högläsning varje dag men det kommer även oplanerade tillfällen. Högläsningsstunderna upplever pedagogerna som lustfyllda och lärorika. Dessutom använder de högläsning som en grund för samtal med barnen.

  • 1167771.
    Yildirim, Ahmet
    et al.
    Siirt Univ, Dept Phys, TR-56100 Siirt, Turkey.
    Wassenaar, Tsjerk A.
    Univ Groningen, Groningen Biomol Sci & Biotechnol Inst, NL-9747 AG Groningen, Netherlands;Univ Groningen, Zernike Inst Adv Mat, NL-9747 AG Groningen, Netherlands.
    Van der Spoel, David
    Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Computational Biology and Bioinformatics.
    Statistical efficiency of methods for computing free energy of hydration2018In: Journal of Chemical Physics, ISSN 0021-9606, E-ISSN 1089-7690, Vol. 149, no 14, article id 144111Article in journal (Refereed)
    Abstract [en]

    The hydration free energy (HFE) is a critical property for predicting and understanding chemical and biological processes in aqueous solution. There are a number of computational methods to derive HFE, generally classified into the equilibrium or non-equilibrium methods, based on the type of calculations used. In the present study, we compute the hydration free energies of 34 small, neutral, organic molecules with experimental HFE between + 2 and 16 kcal/mol. The one-sided non-equilibrium methods Jarzynski Forward (JF) and Backward (JB), the two-sided non-equilibrium methods Jarzynski mean based on the average of JF and JB, Crooks Gaussian Intersection (CGI), and the Bennett Acceptance Ratio (BAR) are compared to the estimates from the two-sided equilibrium method Multistate Bennett Acceptance Ratio (MBAR), which is considered as the reference method for HFE calculations, and experimental data from the literature. Our results show that the estimated hydration free energies from all the methods are consistent with MBAR results, and all methods provide a mean absolute error of similar to 0.8 kcal/mol and root mean square error of similar to 1 kcal for the 34 organic molecules studied. In addition, the results show that one-sided methods JF and JB result in systematic deviations that cannot be corrected entirely. The statistical efficiency epsilon of the different methods can be expressed as the one over the simulation time times the average variance in the HFE. From such an analysis, we conclude that epsilon(MBAR) > epsilon(BAR) approximate to epsilon(CGI) > epsilon(JX), where JX is any of the Jarzynski methods. In other words, the non-equilibrium methods tested here for the prediction of HFE have lower computational efficiency than the MBAR method. 

  • 1167772.
    Yildirim, Ahmet
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Computational Biology and Bioinformatics. Siirt Univ, Fac Sci & Art, Dept Phys, TR-56100 Siirt, Turkey..
    Zhang, Jin
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Computational Biology and Bioinformatics. Zhejiang Univ, Dept Chem, Hangzhou 310027, Peoples R China..
    Manzetti, Sergio
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Computational Biology and Bioinformatics.
    van der Spoel, David
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Computational Biology and Bioinformatics.
    Binding of Pollutants to Biomolecules: A Simulation Study2016In: Chemical Research in Toxicology, ISSN 0893-228X, E-ISSN 1520-5010, Vol. 29, no 10, p. 1679-1688Article in journal (Refereed)
    Abstract [en]

    A number of cases around the world have been reported where animals were found dead or dying with symptoms resembling a thiamine (vitamin B) deficiency, and for some of these, a link to pollutants has been suggested. Here, we investigate whether biomolecules involved in thiamin binding and transport could be blocked by a range of different pollutants. We used in silico docking of five compound classes (25 compounds in total) to each of five targets (prion protein, ECF-type ABC transporter, thi-box riboswitch receptor, thiamin pyrophosphokinase, and YKoF protein) and subsequently performed molecular dynamics (MD) simulations to assess the stability of the complexes. The compound classes were thiamin analogues (control), pesticides, veterinary medicines, polychlorinated biphenyls, and dioxins, all of which are prevalent in the environment to some extent. A few anthropogenic compounds were found to bind the ECF-type ABC transporter, but none binds stably to prion protein. For the riboswitch, most compounds remained in their binding pockets during 50 ns of MD simulation, indicating that RNA provides a promiscuous binding site. In both YKoF and thiamin pyrophosphokinase (TPK), most compounds remain tightly bound. However, TPK biomolecules undergo pollutant-induced conformational changes. Although most compounds are found to bind to some of these targets, a larger data set is needed along with more quantitative methods like free energy perturbation calculations before firm conclusions can be drawn. This study is in part a test bed for large-scale quantitative computational screening of interactions between biological entities and pollutant molecules.

  • 1167773.
    Yildirim, Frida
    et al.
    Mälardalen University, School of Health, Care and Social Welfare.
    Qurioz Villalobos, Valeska
    Mälardalen University, School of Health, Care and Social Welfare.
    Upplevelser av delaktighet: I vården utifrån patientperspektiv2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Background: Having a communication with the caregiver gives the patient an option to participate. It is of importance that the relationship between the two is built on trust due to the needs and wishing of patients fulfils. Aim: The purpose of the thesis is to describe patient’s experiences of participation in care. Method: Twelve articles have been analysed in accordance with a systematic literature study by a descriptive synthesis. Result: A relationship built in confidence was created when the patients were prioritized by the caregivers. Another important attribute is being responsive, since the patients feels appreciated in relation with the caregivers. By being open and responsive the confidence increases which leads to a decrease in anxiety for the patients. When a suitable environment is created it entails that the patients feel the motivation for participation. Conclusion: The experience of participation is based on the patient's perspective. The relationship to participation is built on the basis of trust and motivation from the caregivers. It is important that the caregiver is responsive at every care opportunity to satisfy the needs.  The caregivers pay attention to each patient's needs leads to increased participation

  • 1167774. Yildirim, H. C.
    et al.
    Marquis, Gary
    KTH, School of Engineering Sciences (SCI), Aeronautical and Vehicle Engineering, Lightweight Structures.
    Notch stress analyses of high-frequency mechanical impact-improved welds by using rho(f) = 1 mm and rho(f) = rho + 1 mm approaches2014In: Fatigue & Fracture of Engineering Materials & Structures, ISSN 8756-758X, E-ISSN 1460-2695, Vol. 37, no 5, p. 561-569Article in journal (Refereed)
    Abstract [en]

    This paper presents further assessments of the previously reported round-robin fatigue data obtained from high-frequency mechanical impact (HFMI)-improved longitudinal welds. A detailed statistical analyses of geometry measurements of HFMI-treated weld toe profiles are presented. The fatigue analyses based on notch stress as defined by the International Institute of Welding are performed using the finite element method. Notch stresses are assessed based on both the fictitious weld toe radius and the addition of measured actual notch radius to the fictitious radius. While no large differences are observed between the results of methods, the former one is found to be more practical and faster to implement from the end-user point of view.

  • 1167775. Yildirim, H. C.
    et al.
    Marquis, Gary
    KTH, School of Engineering Sciences (SCI), Aeronautical and Vehicle Engineering, Lightweight Structures. Aalto University, Finland .
    Sonsino, C. M.
    Lightweight potential of welded high-strength steel joints from S700 under constant and variable amplitude loading by high-frequency mechanical impact (HFMI) treatment2015In: Procedia Engineering, 2015, no C, p. 467-475Conference paper (Refereed)
    Abstract [en]

    Investigations with longitudinal stiffeners of the steel grade S700 under fully-reversed, constant amplitude loading and under variable amplitude loading with a straight-line spectrum show impressive fatigue strength improvement by high-frequency mechanical impact (HFMI) treatment. However, the degree of improvement was for variable amplitude loading lower when compared to constant amplitude loading due to local plasticity which occurs during larger load levels and consequently reduces the beneficial compressive residual stresses. Apart from the HFMI-treatment, the exceedance of constant amplitude loading (Woehler-lines) by variable amplitude loading (Gassner-lines) offers further lightweight potential, despite the lower degree of improvement by HFMI under spectrum loading.

  • 1167776. Yildirim, Halid Can
    et al.
    Leitner, Martin
    Marquis, Gary B.
    KTH, School of Engineering Sciences (SCI), Aeronautical and Vehicle Engineering, Lightweight Structures. Department of Applied Mechanics, School of Engineering, Aalto University, Aalto, Finland.
    Stoschka, Michael
    Barsoum, Zuheir
    KTH, School of Engineering Sciences (SCI), Aeronautical and Vehicle Engineering, Lightweight Structures. Department of Aerospace Engineering, Khalifa University of Science, Technology and Research (KUSTAR), P.O. Box: 127788, Abu Dhabi, United Arab Emirates.
    Application studies for fatigue strength improvement of welded structures by high-frequency mechanical impact (HFMI) treatment2016In: Engineering structures, ISSN 0141-0296, E-ISSN 1873-7323, Vol. 106, p. 422-435Article in journal (Refereed)
    Abstract [en]

    In 2013, a new guideline for the design of high-frequency mechanical impact (HFMI) treatment was drafted. The proposed design curves were made based on the fatigue data of axially-loaded welded joints which were manufactured from high-strength steels. All the S-N curves were shown to be conservative with respect to the existing fatigue data for laboratory-scale specimens of longitudinal, transverse, and butt welds. In reality, structures in civil, offshore, mechanical engineering and ship industries generally include large-scale and more complicated components rather than laboratory-scale specimens. Therefore, this paper firstly presents the validation of design proposals by considering fatigue data sets for large-scale welded structures. In total, 62 fatigue data points for bridge, crane and beam-like components are reported, in which the yield strength varies from 250 to 725 MPa, and stress ratio varies from -1 to 0.56. Validations are then extended also for cover plates by performing fatigue tests of 23 weld details both in as-welded and HFMI-treated cases for the use of crane industry. Both the extracted and obtained fatigue data are found to be in good agreement with the previously-proposed design guidelines for nominal and effective notch stress assessment.

  • 1167777. Yildirim, Halid Can
    et al.
    Marquis, Gary B.
    KTH, School of Engineering Sciences (SCI), Aeronautical and Vehicle Engineering, Lightweight Structures.
    A round robin study of high-frequency mechanical impact (HFMI)-treated welded joints subjected to variable amplitude loading2013In: Welding in the World, ISSN 0043-2288, E-ISSN 1878-6669, Vol. 57, no 3, p. 437-447Article in journal (Refereed)
    Abstract [en]

    High-frequency mechanical impact (HFMI) treatment has been significantly developed as a reliable, effective and user-friendly method for post-weld fatigue strength improvement technique for welded structures. The development of an International Institute of Welding best practice guideline for implementing HFMI has been hindered by the lack of directly comparable experimental data for numerous HFMI methods. In this study, nominally identical longitudinal attachments in high-strength steel were manufactured in one welding workshop and distributed to four HFMI equipment manufacturers for treatment. Specimens were fatigue tested on a machine using identical variable amplitude loading histories. HFMI groove measurements were done for each specimen and X-ray diffraction-based residual stress measurements were performed on 10 specimens. The HFMI groove dimensions and the residual stress states showed similarity in general, however small changes were observed. Experimental results indicate that all of the HFMI-improved welds from the HFMI equipment manufacturers satisfied the previously proposed characteristic S-N line based on both the yield strength and the specimen geometry. Results of the study are valuable and promising with respect to the development of a future guideline. The goal of the study has not been to compare treatments, so specific data points are not associated specific HFMI equipment manufacturers.

  • 1167778. Yildirim, Halid Can
    et al.
    Marquis, Gary B.
    KTH, School of Engineering Sciences (SCI), Aeronautical and Vehicle Engineering, Lightweight Structures.
    Fatigue design of axially-loaded high frequency mechanical impact treated welds by the effective notch stress method2014In: Materials and Design, ISSN 0261-3069, Vol. 58, p. 543-550Article in journal (Refereed)
    Abstract [en]

    The effective notch stress method (ENS) as defined by the International Institute of Welding is widely used by design engineers to assess the fatigue strength of welded components. This paper provides a comprehensive evaluation of published data for welded joints improved by high frequency mechanical impact (HFMI) treatment. The goal is to verify already-known fatigue classes for the ENS with the available axially-loaded fatigue data. In total, 280 experimental test results obtained from longitudinal, cruciform and butt welds subject to stress ratio of R = 0.1 axial loading are evaluated. Notch stress concentration factors (K-n) for each joint geometry are analysed based on the finite element method. Calculated K-n and reported nominal stress values are used to determine local stresses. Fatigue strength assessment of the all available data is performed by the previously-proposed and verified correction procedure for yield strength (f(y)). A formerly-defined minimum K-n values as a function of f(y) is used for butt welds. The already-known fatigue classes are found to be conservative with respect to available fatigue test data.

  • 1167779. Yildirim, Halid Can
    et al.
    Marquis, Gary B.
    KTH, School of Engineering Sciences (SCI), Aeronautical and Vehicle Engineering, Lightweight Structures. Aalto University, Finland.
    Barsoum, Zuheir
    KTH, School of Engineering Sciences (SCI), Aeronautical and Vehicle Engineering, Lightweight Structures.
    Fatigue assessment of high frequency mechanical impact (HFMI)-improved fillet welds by local approaches2013In: International Journal of Fatigue, ISSN 0142-1123, E-ISSN 1879-3452, Vol. 52, p. 57-67Article in journal (Refereed)
    Abstract [en]

    Local fatigue assessment methods like the structural hot spot stress and effective notch stress methods as defined by the International Institute of Welding are widely used by design engineers and researchers to assess the fatigue strength of welded components. This paper provides a comprehensive evaluation of published data for welded joints which had been improved using high frequency mechanical impact (HFMI) treatment. All of the published data for HFMI-treated welds are presented in terms of nominal stress. The goal of the current paper is to establish local fatigue assessment procedures for improved fillet welds. In total, 160 published experimental results for longitudinal and cruciform welds subjected to R = 0.1 axial loading are evaluated. Local stress quantities for each joint were assessed based on the finite element analyses and reported nominal stress values. A correction procedure for yield strength that was previously verified for nominal stress-based fatigue assessment is also applied to the local stress methods studied in this paper. For both the structural hot spot stress and effective notch stress methods, sets of characteristic fatigue strength curves as functions of yield strength are proposed and verified. The structural hot spot stress method includes one set of fatigue strength curves for load-carrying welds and a second set for non-load carrying welds. The effective notch stress method includes a single set of curves for all welds. All of the design curves proposed in this study are conservative with respect to available fatigue test data.

  • 1167780. Yildirim, H.C.
    et al.
    Marquis, Gary
    KTH, School of Engineering Sciences (SCI), Aeronautical and Vehicle Engineering, Lightweight Structures. Department of Applied Mechanics, Aalto University, Finland.
    Fatigue data of High-Frequency Mechanical Impact (HFMI) improved welded joints subjected to overloads2015In: Analysis and Design of Marine Structures: Proceedings of the 5th International Conference on Marine Structures, MARSTRUCT 2015, 2015, p. 317-322Conference paper (Refereed)
    Abstract [en]

    In the past decade, High Frequency Mechanical Impact (HFMI) has significantly developed as a reliable, effective and user-friendly method for post-weld fatigue strength improvement technique for welded steel structures. The evaluation and features of developing guideline within the International Institute of Welding (IIW) for the design of structures improved using HFMI is briefly discussed. So far, the extra fatigue strength benefit for HFMI-treated high strength steels has been mostly shown for constant amplitude loading. This paper reports 68 available HFMI-improved welds subjected to overloads or pre-fatigue loads at various loading conditions prior to fatigue testing. These loading conditions are often seen for marine structures.

  • 1167781.
    Yildirim, Håkan H.
    Södertörn University, School of Life Sciences. Karolinska Institutet.
    Structural diversity of the lipid A and core oligosaccharide moieties of the lipopolysaccharides from nontypeable and serotype f Haemophilus influenzae2005Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    This thesis describes structural studies of the oligosaccharide and lipid A moieties of lipopolysaccharides (LPSs) isolated from disease-causing Haemophilus influenzae strains. The nontypeable strains were clinical isolates from the middle ear of children suffering from otitis media and the serotype f strains had been collected from three adults with respiratory tract infections. The LPS molecules are situated on the cell wall of H. influenzae strains and they play a very important role in colonization, infection, evasion of host immune system and inflammatory response. Previous studies have implicated the heterogeneous repertoire of LPS structures within a strain and mimicry of human cell wall structures to be involved in the diseasecausing behavior of this organism. Structural analysis of the oligosaccharide moieties with advanced applications of nuclear magnetic resonance (NMR) and various electrospray ionization mass spectrometry (ESI-MS) techniques revealed novel structural features in each of the investigated strains. All of the strains displayed a very complex mixture of LPS structures that differed between and within the pathogens. Moreover, all of the strains had the capacity to express mimics of human glycolipids. The genetic basis for LPS biosynthesis for H. influenzae is established for the strain of which the complete genome has been determined. In this thesis the function of the genes involved in the biosynthesis of LPS was investigated in a nontypeable strain by using the combination of genetic engineering and structural analysis. The synergy of genomics and analytical carbohydrate chemistry led to the identification of novel structural epitopes, and furthermore, enabled us to identify a new function for one of these genes. The most recent structural study of lipid A from H. influenzae was conducted in 1988 on a mutant strain. The results of that study established the presence of only one lipid A structure. in this thesis we investigated lipid A from both nontypeable and serotype wild type strains by performing tandem ESI-MS and the results confirmed earlier findings but also evidenced other lipid A structures previously not associated with H. influenzae. Moreover, all of the strains exhibited a heterogeneous population of lipid A molecules.

  • 1167782.
    Yildirim, Håkan H.
    et al.
    Södertörn University, School of Life Sciences. Karolinska Institutet.
    Hood, D W
    University of Oxford, John Radcliffe Hostpital, Oxford, UK.
    Moxon, E R
    University of Oxford, John Radcliffe Hostpital, Oxford, UK.
    Schweda, Elke K. H.
    Södertörn University, School of Life Sciences. Karolinska Institutet.
    Structural analysis of lipopolysaccharides from Haemophilus influenzae serotype f - Structural diversity observed in three strains2003In: European Journal of Biochemistry, ISSN 0014-2956, E-ISSN 1432-1033, Vol. 270, no 15, p. 3153-3167Article in journal (Refereed)
    Abstract [en]

    Structural elucidation of the lipopolysaccharide (LPS) from three serotype f Haemophilus influenzae clinical isolates RM6255, RM7290 and RM6252 has been achieved using NMR spectroscopy techniques and ESI-MS on O-deacylated LPS and core oligosaccharide material (OS) as well as ESI-MSn on permethylated dephosphorylated OS. This is the first study to report structural details on LPS from serotype f strains. We found that the LPSs of all strains were highly heterogeneous mixtures of glycoforms expressing the common H. influenzae structural element l-alpha-d-Hepp -(1-->2)-[P Etn-->6]-l-alpha-d-Hepp -(1-->3)-[beta-d-Glcp -(1-->4)]-l-alpha-d-Hepp -(1-->5)-[PP Etn-->4]-alpha-Kdo-(2-->6)-lipid A with variable length of OS chains linked to each of the heptoses. The terminal heptose (HepIII) in RM6255 is substituted at the O-3 position by a beta-d-Glcp residue whereas HepIII in strains RM7290 and RM6252 is substituted at O-2 by the globoside unit (alpha-d-Galp -(1-->4)-beta-d-Galp -(1-->4)-beta-d-Glc) or truncated versions thereof. The central heptose (HepII) is substituted by an alpha-d-Galp -(1-->4)-beta-d-Galp -(1-->4)-beta-d-Glcp -(1-->4)-alpha-d-Glcp unit in RM7290 and RM6252 or truncated versions thereof. Strain RM6255 does not express galactose in its LPS and only shows a cellobiose unit elongating from HepII (beta-d-Glcp -(1-->4)-alpha-d-Glcp ). ESI-MSn on dephosphorylated and permethylated OS provided information on the existence of additional minor isomeric glycoforms.

  • 1167783.
    Yildirim, Håkan H.
    et al.
    Södertörn University, School of Life Sciences. Karolinska Institutet.
    Li, J J
    National Research Council of Canada, Ottawa, Canada.
    Richards, J C
    National Research Council of Canada, Ottawa, Canada.
    Hood, D W
    John Radcliffe Hospital, Oxford, UK.
    Moxon, E R
    John Radcliffe Hospital, Oxford, UK.
    Schweda, Elke K. H.
    Södertörn University, School of Life Sciences. Karolinska Institutet.
    An alternate pattern for globoside oligosaccharide expression in Haemophilus influenzae lipopolysaccharide: Structural diversity in nontypeable strain 11242005In: Biochemistry, ISSN 0006-2960, E-ISSN 1520-4995, Vol. 44, no 13, p. 5207-5224Article in journal (Refereed)
    Abstract [en]

    Common structural motifs of Haemophilus influenzae lipopolysaccharide (LPS) are globotetraose [beta-D-GalpNAc-(1 -> 3)-alpha-D-Galp-(1 -> 4)-beta-D-Galp-(1 -> 4)-beta-D-Glcp] and its truncated versions globoside [alpha-D-Galp-(1 -> 4)-beta-D-Galp-(1 -> 4)-beta-D-Glcp] and lactose [beta-D-Galp-(1 -> 4)-beta-D-Glcp] linked to the tenninal heptose (HepIII) of the triheptosyl inner-core moiety L-alpha-D-Hepp-(1 -> 2)-[PEA -> 6]-L-alpha-D-Hepp-(1 -> 3)L-alpha-D-Hepp-(1 -> 5)-[PPEA -> 4]-alpha-Kdo-(2 -> 6)-lipid A. We report here structural studies of LPS from nontypeable H. influenzae strain 1124 expressing these motifs linked to both the proximal heptose (HepI) and HepIII at the same time. This novel finding was obtained by structural studies of LPS using NMR techniques and electrospray ionization mass spectrometry (ESI-MS) on O-deacylated LPS and core oligosaccharide material (OS) as well as ESI-MSn on permethylated dephosphorylated OS. The use of defined mutants allowed us to confirm structures unambiguously and understand better the biosynthesis of each of the globotetraose units. We found that lgtC is involved in the expression of beta-D-Galp-(1 -> 4)-beta-D-Galp in both extensions, whereas lic2A directs only the expression Of beta-D-Ga1p-(1 -> 4)-beta-D-Glcp when linked to HepIII. The LPS of NTHi strain 1124 contained sialylated glycoforms that were identified by CE-ESI-MS/MS. A common sialylated structure in H. influenzae LPS is sialyllactose linked to HepIII. This structure exists in strain 1124. However, results for the lpsA mutant indicate that sialyllactose extends from HepI as well, a molecular environment for sialyllactose in H. influenzae that has not been reported previously. In addition, the LPS was found to carry phosphoryleholine, O-linked glycine, and a third PEA group which was linked to O3 of HepIII.

  • 1167784.
    Yildirim, Håkan H
    et al.
    Södertörn University, School of Life Sciences. Karolinska institutet.
    Li, J J
    National Research Council, Ottawa, Canada.
    Richards, J C
    National Research Council, Ottawa, Canada.
    Hood, D W
    John Radcliffe Hospital, Oxford, UK.
    Moxon, E R
    John Radcliffe Hospital, Oxford, UK.
    Schweda, Elke K H
    Södertörn University, School of Life Sciences. Karolinska Institutet.
    Complex O-acetylation in non-typeable Haemophilus influenzae lipopolysaccharide: evidence for a novel site of O-acetylation2005In: Carbohydrate Research, ISSN 0008-6215, E-ISSN 1873-426X, Vol. 340, no 17, p. 2598-2611Article in journal (Refereed)
    Abstract [en]

    The structure of the lipopolysaccharide (LPS) of non-typeable Haemophilus influenzae strain 723 has been elucidated using NMR spectroscopy and electrospray ionization mass spectrometry (ESI-MS) on O-deacylated LPS and core oligosaccharide material (OS), as well as ESI-MSn on permethylated dephosphorylated OS. It was found that the LPS contains the common structural element of H. influenzae, L-alpha-D-Hepp-(1 -> 2)-[PEtn -> 6]-L-alpha-D-Hepp-(1 -> 3)-[beta-D-Glcp-(1 -> 4)]-L-alpha-D-Hepp-(1 -> 5)-[PPEtn -> 4]-alpha-Kdo-(2 -> 6)-Lipid A, in which the beta-D-Glcp residue (GlcI) is substituted by phosphocholine at O-6 and the distal heptose residue (HepIII) by PEW at O-3, respectively. In a subpopulation of glycoforms O-2 of HepIII was substituted by beta-D-Galp-(1 -> 4)-beta-D-Glcp-(1 -> or beta-D-Glcp-(1 ->. Considerable heterogeneity of the LPS was due to the extent of substitution by O-acetyl groups (Ac) and ester-linked glycine of the core oligosaccharide. The location for glycine was found to be at Kdo. Prominent acetylation sites were found to be at GlcI, HepIII, and the proximal heptose (HepI) residue of the triheptosyl moiety. Moreover, GlcI was acetylated at O-3 and/or O-4 and HepI was acetylated at O-2 as evidenced by capillary electrophoresis ESI-MS" in combination with NMR analyses. This is the first study to show that an acetyl group can substitute HepI of the inner-core region of H. influenzae LPS.

  • 1167785.
    Yildirim, Julia
    et al.
    Södertörn University College, School of Business Studies.
    Atto, Rand
    Södertörn University College, School of Business Studies.
    Revisorers anmälningsskyldighet vid misstanke om brott: Hur har lagändringen sedan år 1999 påverkat revisorerna?2009Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 1167786.
    Yildirim, Kani
    Mid Sweden University, Faculty of Science, Technology and Media, Department of Information Systems and Technology.
    Optimization algorithm selection for object detection and segmentation with Mask R-CNN2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Deep learning is a field within machine learning that has grown in popularity. It is used in areas such as: image classification, speech recognition, market price predictions, object detection and much more. The main objective of this study has been to, on the requests of a company, train a model using deep learning to be able to classify and produce masks of objects of interest within images. A comparison of different optimization algorithms was done in order to identify the optimal one for the task at hand. Pixel-wise annotations of the objects were produced in order to train the model. By altering the code of Matterports implementation of Mask R-CNN to train on the dataset (of images) provided by HIAB, the goals were achieved. The optimization algorithm best suited for the conditions of this study was concluded to be AdaGrad. This was concluded based on the mean value of the total loss for each optimization algorithm. In future work, the dataset would preferably be larger in order to increase the predictive quality of the model.

  • 1167787.
    YILDIRIM, Nazlı Irmak
    Linnaeus University, Faculty of Science and Engineering, School of Computer Science, Physics and Mathematics.
    How fractions are introduced in compulsory school: A comparative study of Grade 6 textbooks in Turkey and Sweden2012Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Abstract

     

    The purpose of this study is to provide a detailed description of the way fractions are processed in Turkish and Swedish mathematics textbooks. For our investigation of textbooks, we used several theoretical notions  such us different ways of understanding fractions (part-whole, ratio, measure, quotient, decimal and operator), representations (treatment, conversion), making distinctions between routine tasks and problems, classifying contexts of examples and problems in terms of real-life situations, semi-realities, and pure mathematics, and about texts narrative and paradigmatic styles.

     

    Through our analyses of these three textbooks, we have come to a result that shows similarities and differences among the textbooks, regarding the topics included and their sequencing, how the concept of fractions is represented in exercises and examples.

    The findings are emphasized with figures, tables and diagrams that illustrate the similarities and differences between mathematics textbooks inTurkeyinSwedenas well as the textbooks’ development in Turkey.

  • 1167788.
    YILDIRIM, NURSEDA
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences.
    TIME SERIES MODELLING FOR WIND POWER PREDICTION AND CONTROL: CLUSTERING AND ASSOCIATION RULES OF DATA MINING FOR CFD AND TIME SERIES DATA OF POWER RAMPS2014Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
  • 1167789.
    Yildirim, Nurseda
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Electricity.
    Uzunoglu, Bahri
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Electricity.
    Association Rules for Clustering Algorithms for Data Mining of Temporal Power Ramp Balance2015In: Cyberworlds, 2015 IEEE, 2015, p. 224-228Conference paper (Refereed)
    Abstract [en]

    Power ramp estimation is utmost importance for wind power plants which will be the focus of this paper. Power ramps are caused by intermittent supply of wind power generation. This is an important problem in the power system that needs to keep the load and generation at balance at all times while any unbalance leads to price volatility, grid security issues that can create power stability problems that leads to financial losses. In this study, K-means clustering and association rules of apriori algorithm are implemented to analyze and predict wind power ramp occurrences based on 10 minutes temporal SCADA data of power from records of Ayyildiz wind farm. Power ramps are computed from this data. Five wind turbines with no dissimilarity measure in space were clustered based on temporal data. The power ramp data are analyzed by the K-means algorithm for calculation of their cluster means and cluster labels. Association rules of data mining algorithm were employed to analyze temporal ramp occurrences between wind turbines. Each turbine impact on the other turbines were analyzed as different transactions at each time step. Operational rules based on these transactions are discovered by an apriori association rule algorithm for operation room decision making. Discovery of association rules from an apriori algorithm can help with decision making for power system operator.

  • 1167790.
    Yildirim, Nurseda
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Electricity.
    Uzunoglu, Bahri
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Electricity. Florida State Univ, Dept Math, Tallahassee, FL 32310 USA..
    Data Mining via Association Rules for Power Ramps Detected by Clustering or Optimization2016In: Transactions on Computational Science XXVIII: Special Issue on Cyberworlds and Cybersecurity / [ed] Gavrilova, ML; Tan, CJK; Sourin, A, Springer Berlin/Heidelberg, 2016, p. 163-176Conference paper (Refereed)
    Abstract [en]

    Power ramp estimation has wide ranging implications for wind power plants and power systems which will be the focus of this paper. Power ramps are large swings in power generation within a short time window. This is an important problem in the power system that needs to maintain the load and generation at balance at all times. Any unbalance in the power system leads to price volatility, grid security issues that can create power stability problems that leads to financial losses. In addition, power ramps decrease the lifetime of turbine and increase the operation and maintenance expenses. In this study, power ramps are detected by data mining and optimization. For detection and prediction of power ramps, data mining K means clustering approach and optimisation scoring function approach are implemented [1]. Finally association rules of data mining algorithm is employed to analyze temporal ramp occurrences between wind turbines for both clustering and optimization approaches. Each turbine impact on the other turbines are analyzed as different transactions at each time step. Operational rules based on these transactions are discovered by an Apriori association rule algorithm for operation room decision making. Discovery of association rules from an Apriori algorithm will serve the power system operator for decision making.

  • 1167791.
    Yildirim, Nurseda
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Electricity.
    Uzunoglu, Bahri
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Electricity.
    Spatial Clustering for Temporal Power Ramp Balance and Wind Power Estimation2015In: Green Technologies Conference (GreenTech), 2015 Seventh Annual IEEE, 2015, p. 214-220Conference paper (Refereed)
    Abstract [en]

    Power estimation and power ramp estimation is of crucial importance in renewable energy applications especially for wind power plants that is going to be the focus of this study. Intermittent supply of wind power generation can cause power ramps which are sudden change of power production in time. This is an important problem in power system that aims to keep the load and generation balance. Unbalance in the system can lead to price volatility and grid security issues that will create power stability problems and financial losses. Herein a spatial clustering methodology for improving spatio-temporal relations are investigated to improve wind power estimation and power ramp estimation. To validate the data with the model that will be used in clustering analysis, spatial results of Computational Fluid Dynamics (CFD) tool simulations are employed to test suggested methodology in space. CFD results generate the input data for space clustering process. Via the CFD generated spatial information, the relationship between spatial clustering to wind power ramp rate characteristics of wind Turbines are introduced for the spatio-temporal power and power ramp rate relations. Spatial relations for power ramp characteristics of each node in wind resource map is introduced. In space scales, K-means algorithm is used to create spatial Power Ramp Rate (PRR) based clusters to define most related clusters in space so that impact of each spatial cluster can be introduced.

  • 1167792.
    Yildirim, Siho
    et al.
    KTH, School of Architecture and the Built Environment (ABE), Civil and Architectural Engineering, Building Technology and Design.
    Rashid, Omar
    KTH, School of Architecture and the Built Environment (ABE), Civil and Architectural Engineering, Building Technology and Design.
    Effektivisering av teknikhusens grundläggningar längs järnvägar: Ett arbete som behandlar behovet om att effektivisera standarden för grundläggningen av ett teknikhus.2017Independent thesis Basic level (university diploma), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Trafikverket is responsible for one of Sweden’s largest infrastructure project, namely replacing the current signal system along the countries railway to ERTMS. With the replacement of the signal system comes the need to replace 1 500 equipment shelters. The task is to analyze costs for the equipment shelter’s current foundation standard and try to find cheaper solutions. The work is mainly executed by analyzing alternative materials and foundations, but also manufacturing, installation, logistics, impacting loads and geology. One of the goals is to reduce the current costs of the project, and the main task is to find a new foundation standard that Trafikverket can use for future equipment shelters. The most common foundation types for equipment shelters turned out to be crawling spaces and plinth foundations out of sheet-metal and concrete. The report also presents ground screws, which is a new idea for equipment shelters. The report’s conclusion is that ground screws are the cheapest and most flexible foundation for equipment shelters. Even sheet-metal frames, which are a more common option today, proved to be a more economical choice than the current standard. The total saving turned out to be near 34 million SEK with ground screws and therefore one of the objectives has been achieved. The main goal of possibly finding a new standard, however, requires future investigations by Trafikverket before it can be determined possible.

    A recommendation to Trafikverket is to further investigate the price of foreign suppliers’ ground screws and determine if the installation is to be carried out on its own. For further studies, a detailed cost analysis of cantilevered houses and transports is recommended.

  • 1167793.
    Yildirim, Tugay
    et al.
    Karlstad University, Faculty of Arts and Social Sciences (starting 2013), Karlstad Business School (from 2013).
    Rohlin, Oscar
    Karlstad University, Faculty of Arts and Social Sciences (starting 2013), Karlstad Business School (from 2013).
    Prestationsmätningars roll i revisionsbyråer: En kvalitativ studie utifrån revisorers perspektiv2018Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Abstract

    Management control system is meaningful for corporations.  It aims to define overall company-goals and develops strategies that eases the achievement of these goals. The purpose of the strategies is to create desirable performances through guidance of employees. The strategy and performance evaluation are correlated since both creates desirable performances. This is achieved through performance evaluation as it monitors and examines employees’ performances. 

    Prior research highlights performance evaluation through corporations' perspective, but does not present a connection between performance evaluation and its effects on auditors. Although, it has been established some effects of parts within performance evaluation. Due to that the research has been based on corporations' perspective, it becomes interesting to study the subject through auditors’ perspective. Performance evaluation is used in a wide variety within the large audit firms, thus relevant to study. 

    The purpose of the thesis is to create a broader understanding of which role performance evaluation has in audit firms. This has been studied through observations of how performance evaluation is executed and which effects it has on auditors. The thesis’s research-strategy is qualitative, though empirical data has been generated through interviews with eleven auditors. 

    All of the researched audit firms include overall company-goals, individual goalsetting, time budgets, feedback and monetary incentives in the process of execution of performance evaluation. This study presents which effects performance evaluation has on auditors. Positive effects of performance evaluation are increased performances and motivation. This increment is based on increased self-efficacy, clear expectations and guidelines, and active participation during goal-setting and feedback processes. The negative effects of performance evaluation are based on the work procedure that is created by the management tool, in terms of time pressure, stress and pressure regarding acquisition of customers. 

  • 1167794.
    Yildirim, Yeserin
    et al.
    Linnaeus University, Faculty of Health and Life Sciences, Department of Biology and Environmental Science. Massey Univ, New Zealand.
    Anderson, Marti J.
    Massey Univ, New Zealand.
    Hansson, Bengt
    Lund University.
    Patel, Selina
    Univ Auckland, New Zealand.
    Millar, Craig D.
    Univ Auckland, New Zealand.
    Rainey, Paul B.
    Massey Univ, New Zealand;Max Planck Inst Evolutionary Biol, Germany;PSL Res Univ, France.
    Genetic structure of the grey side-gilled sea slug (Pleurobranchaea maculata) in coastal waters of New Zealand2018In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 13, no 8, article id e0202197Article in journal (Refereed)
    Abstract [en]

    Pleurobranchaea maculata is a rarely studied species of the Heterobranchia found throughout the south and western Pacific-and recently recorded in Argentina-whose population genetic structure is unknown. Interest in the species was sparked in New Zealand following a series of dog deaths caused by ingestions of slugs containing high levels of the neurotoxin tetrodotoxin. Here we describe the genetic structure and demographic history of P. maculata populations from five principle locations in New Zealand based on extensive analyses of 12 microsatellite loci and the COI and CytB regions of mitochondrial DNA (mtDNA). Microsatellite data showed significant differentiation between northern and southern populations with population structure being associated with previously described regional variations in tetrodotoxin concentrations. However, mtDNA sequence data did not support such structure, revealing a star-shaped haplotype network with estimates of expansion time suggesting a population expansion in the Pleistocene era. Inclusion of publicly available mtDNA sequence sea slugs from Argentina did not alter the star-shaped network. We interpret our data as indicative of a single founding population that fragmented following geographical changes that brought about the present day north-south divide in New Zealand waters. Lack of evidence of cryptic species supports data indicating that differences in toxicity of individuals among regions are a consequence of differences in diet.

  • 1167795.
    Yildirim, Yeserin
    et al.
    Linnaeus University, Faculty of Health and Life Sciences, Department of Biology and Environmental Science.
    Tinnert, Jon
    Linnaeus University, Faculty of Health and Life Sciences, Department of Biology and Environmental Science.
    Forsman, Anders
    Linnaeus University, Faculty of Health and Life Sciences, Department of Biology and Environmental Science.
    Contrasting patterns of neutral and functional genetic diversity in stable and disturbed environments2018In: Ecology and Evolution, ISSN 2045-7758, E-ISSN 2045-7758, Vol. 8, no 23, p. 12073-12089Article in journal (Refereed)
    Abstract [en]

    Genetic structure among and diversity within natural populations is influenced by acombination of ecological and evolutionary processes. These processes can differentlyinfluence neutral and functional genetic diversity and also vary according toenvironmental settings. To investigate the roles of interacting processes as drivers ofpopulation‐level genetic diversity in the wild, we compared neutral and functionalstructure and diversity between 20 Tetrix undulata pygmy grasshopper populations indisturbed and stable habitats. Genetic differentiation was evident among the differentpopulations, but there was no genetic separation between stable and disturbedenvironments. The incidence of long‐winged phenotypes was higher in disturbedhabitats, indicating that these populations were recently established by flight‐capablecolonizers. Color morph diversity and dispersion of outlier genetic diversity, estimatedusing AFLP markers, were higher in disturbed than in stable environments,likely reflecting that color polymorphism and variation in other functionally importanttraits increase establishment success. Neutral genetic diversity estimated usingAFLP markers was lower in disturbed habitats, indicating stronger eroding effects onneutral diversity of genetic drift associated with founding events in disturbed comparedto stable habitats. Functional diversity and neutral diversity were negativelycorrelated across populations, highlighting the utility of outlier loci in genetics studiesand reinforcing that estimates of genetic diversity based on neutral markers donot infer evolutionary potential and the ability of populations and species to copewith environmental change.

  • 1167796.
    Yildirimdemir, Oytun
    KTH, School of Industrial Engineering and Management (ITM), Production Engineering.
    Utformning av Distributionsflöde samt returflöde av defekta produkter i Turkiet: En fallstudie på företaget Axis Communications AB2015Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Axis is one of the world's largest providers of network based surveillance cameras with partners in 179 countries. Axis has over the past years experienced a deterioration of sales growth in the Turkish market despite forecasts showing high market potential. In mean time Axis´s distributor and retailer have expressed dissatisfaction with Axis´s processes for import and handling of faulty units. Therefore the research was designed to map the processes for importation into Turkey and process for faulty units handling, to get an objective view of the situation and suggest potential improvements. Mapping of Axis's processes in Turkey has been done and based on Just--‐In--‐Time and Supply Chain Management literature the research has found potential non--‐value adding activities. Axis has been recommended to introduce new performance measurement points to be able to follow up and improve the importation and faulty units handling in Turkey, and eventually eliminate these non--‐value adding activities. Suggested measurements: • Ratio between the value of goods shipped and administrative costs for its imports. • The lead--‐time for the distributor to replace a faulty unit from its first encounter with customer. With help of these measurements initiatives can easier be taken and action be made to improve the situation. Some suggestions for improvements are:

    • Consolidation of shipments, see Figure 7 and 8 (p. 19), for low ratio on value goods and administrative expenses . •

    Delivery of import documents directly to the distributor in parallel with the shipment of the goods to avoid delays at customs.

    Keep a limited inventory for replacement of defective products for quick replacement.

  • 1167797.
    Yildirimman, Reha
    et al.
    Max Planck Inst Mol Genet, Dept Vertebrate Genom, D-14195 Berlin, Germany .
    Brolén, Gabriella
    Cellartis AB, SE-41346 Gothenburg, Sweden .
    Vilardell, Mireia
    Max Planck Inst Mol Genet, Dept Vertebrate Genom, D-14195 Berlin, Germany .
    Eriksson, Gustav
    Cellartis AB, SE-41346 Gothenburg, Sweden .
    Synnergren, Jane
    University of Skövde, School of Life Sciences.
    Gmuender, Hans
    Genedata AG, CH-4053 Basel, Switzerland .
    Kamburov, Atanas
    Max Planck Inst Mol Genet, Dept Vertebrate Genom, D-14195 Berlin, Germany .
    Ingelman-Sundberg, Magnus
    Karolinska Inst, Dept Physiol & Pharmacol, Pharmacogenet Sect, S-17177 Stockholm, Sweden .
    Castell, Jose
    Univ Valencia, Fac Med, Dept Biochem & Mol Biol, E-46009 Valencia, Spain / Univ Hosp La Fe Valencia, Unit Expt Hepatol, E-46009 Valencia, Spain .
    Lahoz, Agustin
    Univ Hosp La Fe Valencia, Unit Expt Hepatol, E-46009 Valencia, Spain .
    Kleinjans, Jos
    Maastricht Univ, Dept Toxicogen, NL-6229 ER Maastricht, Netherlands.
    van Delft, Joost
    Maastricht Univ, Dept Toxicogen, NL-6229 ER Maastricht, Netherlands.
    Bjorquist, Petter
    Cellartis AB, SE-41346 Gothenburg, Sweden .
    Herwig, Ralf
    Max Planck Inst Mol Genet, Dept Vertebrate Genom, D-14195 Berlin, Germany .
    Human Embryonic Stem Cell Derived Hepatocyte-Like Cells as a Tool for In Vitro Hazard Assessment of Chemical Carcinogenicity2011In: Toxicological Sciences, ISSN 1096-6080, E-ISSN 1096-0929, Vol. 124, no 2, p. 278-290Article in journal (Refereed)
    Abstract [en]

    Hepatocyte-like cells derived from the differentiation of human embryonic stem cells (hES-Hep) have potential to provide a human relevant in vitro test system in which to evaluate the carcinogenic hazard of chemicals. In this study, we have investigated this potential using a panel of 15 chemicals classified as noncarcinogens, genotoxic carcinogens, and nongenotoxic carcinogens and measured whole-genome transcriptome responses with gene expression microarrays. We applied an ANOVA model that identified 592 genes highly discriminative for the panel of chemicals. Supervised classification with these genes achieved a cross-validation accuracy of > 95%. Moreover, the expression of the response genes in hES-Hep was strongly correlated with that in human primary hepatocytes cultured in vitro. In order to infer mechanistic information on the consequences of chemical exposure in hES-Hep, we developed a computational method that measures the responses of biochemical pathways to the panel of treatments and showed that these responses were discriminative for the three toxicity classes and linked to carcinogenesis through p53, mitogen-activated protein kinases, and apoptosis pathway modules. It could further be shown that the discrimination of toxicity classes was improved when analyzing the microarray data at the pathway level. In summary, our results demonstrate, for the first time, the potential of human embryonic stem cell--derived hepatic cells as an in vitro model for hazard assessment of chemical carcinogenesis, although it should be noted that more compounds are needed to test the robustness of the assay.

  • 1167798.
    Yildirim-Yayilgan, Sule
    et al.
    NTNU, Norway.
    Du, Yang
    NTNU, Norway.
    Dalipi, Fisnik
    NTNU, Norway.
    Jeppesen, Jonas C.
    A New Ski Injury Registration System Architecture Using Mobile Applications to Enhance Skiing Safety2016In: International Journal of Interactive Mobile Technologies (iJIM), ISSN 1865-7923, E-ISSN 1865-7923, Vol. 10, no 4Article in journal (Refereed)
    Abstract [en]

    Mobile apps play an increasingly important role in healthcare institutions by enhancing the quality of healthcare services. Their role in sport injury prevention is also instrumental. In this article, we propose a system architecture for ski injury registration using mobile apps. Our work follows the idea of integrating and using mHealth apps to manage skiing injuries and to provide higher healthcare service quality and faster availability of data. With this work, we aim to greatly simplify the information workflow between the ski patrollers and the medical centers. Having the right information in the right place and on the right time for the injured person, the ski patroller then delivers to the medical centers that information in a format that is easy to analyze by the medical personnel and be prepared for possible interventions. To develop the mobile interfaces for the ski patrollers, nurses and doctors, we employ user-centered design. The overall system features and implementation are also explained and described in this paper. For evaluation purposes of our proposed system architecture, we have conducted a traditional user test of the ski patroller system in collaboration with the ski patrollers in the ski resort of Trysil in Norway. Moreover, a heuristic evaluation with four evaluators is also conducted. The traditional test had two-evaluation points and based on the results of the tests, we obtained implications for enhancing the design of mobile interfaces for the proposed architecture.

  • 1167799. Yildis, Adnan
    et al.
    Zeyfang, Florian
    Making Public: MFA 20102010Collection (editor) (Other (popular science, discussion, etc.))
  • 1167800.
    Yildiz, Ahmet Bahadir
    et al.
    KTH, School of Industrial Engineering and Management (ITM), Materials Science and Engineering.
    Weidow, Jonathan
    Chalmers Univ Technol, Dept Phys, SE-41296 Gothenburg, Sweden..
    Ryukhtin, Vasyl
    Nucl Phys Inst, Cp 130, Husinec Rez 25068, Czech Republic..
    Norgren, Susanne
    Sandvik, SE-12680 Stockholm, Sweden.;Uppsala Univ, Dept Engn Sci, Appl Mat Sci, SE-75121 Uppsala, Sweden..
    Wahnström, Göran
    Chalmers Univ Technol, Dept Phys, SE-41296 Gothenburg, Sweden..
    Hedström, Peter
    KTH, School of Industrial Engineering and Management (ITM), Materials Science and Engineering.
    Very-small angle neutron scattering study on grain coarsening inhibition by V-doping of WC-Co composites2019In: Scripta Materialia, ISSN 1359-6462, E-ISSN 1872-8456, Vol. 173, p. 106-109Article in journal (Refereed)
    Abstract [en]

    The mechanical properties of cemented carbides can be tuned by controlling WC grain coarsening and the simultaneous growth of the binder pocket size during the sintering. So far, bulk studies considering this phenomenon are scarce, but here, we report the first very-small angle neutron scattering (VSANS) study on cemented carbides. VSANS is supplemented with electron backscatter diffraction (EBSD) and the microstructural refinement by increasing V-doping (0, 0.02, 022, and 0.76 wt%) is quantified. The capability of VSANS as a non-destructive bulk probe for cemented carbides is shown, paving way for forthcoming in-situ studies.

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