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  • 1167001.
    Zhang, Lanlan
    KTH, School of Biotechnology (BIO).
    Induced changes in dehydrin gene expression in pine seeds and seedlings2013Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
  • 1167002.
    Zhang, Lanlan
    KTH, School of Biotechnology (BIO).
    Induced changes in dehydrin gene expression in pine sees and seedlings2013Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
  • 1167003.
    Zhang, Laura Hanbing
    et al.
    Stockholm University, Faculty of Social Sciences, School of Business.
    Dahlin, Helena
    Stockholm University, Faculty of Social Sciences, School of Business.
    Mobilmarknadsföring: - Om konsumenters attityder till en potentiell marknadsföringskanal2006Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Denna kandidatuppsats syftar till att studera konsumenters inställning till mobilmarknads-föring och därmed potentialen hos denna nya marknadsföringskanal. För att erhålla en djupare förståelse för detta ämnesområde studerades tidigare forskningsrapporter inom mobilmarknadsföring, aktuella branschrapporter, samt litteratur inom konsumentbeteende och marknadsföring. En kvantitativ studie i form av en webbenkätundersökning genomfördes för att samla in relevant data. Resultaten tyder på att det från konsumenters sida finns ett visst intresse av att denna marknadsföringskanal vidareutvecklas, dock under förutsättningen att kanalen inte missbrukas genom av konsumenterna accepterad frekvens och innehåll av reklamutskick. Åldersgruppen upp till 20 år framstår som mest mottaglig för mobilmarknadsföring. Inställningen till reklam via SMS och MMS var generellt sett likartade. Undersökningen visar även att majoriteten av konsumenterna skulle bli mer positivt inställda till mobilmarknadsföring ifall sådana åtgärder skapade ett mervärde för konsumenten.

  • 1167004.
    Zhang, Le
    KTH, School of Chemical Science and Engineering (CHE).
    Large Scale Production of Polylactide Microspheres for Controlled Drug Delivery2012Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Spray drying is presented as an efficient technique to manufacture spherical polylactide particles in large scale for use in controlled drug delivery applications. Poly (L-lactide) (PLLA) was synthesized by ring-opening polymerization and PLLA microspheres were produced by spray drying. The PLLA microspheres were morphologically characterized by SEM and the release profile of drug loaded in the microspheres were analyzed by UV-VIS. The morphology of PLLA microspheres was significantly influenced by solvent, molecular weight, and the operating settings of the instrument.

    PLLA particles loaded with diclofenac sodium and caffeine were produced using the 10,000 and 20,000 g/mol molecular weight PLLAs and the previously determined operating conditions. The morphologies of particles loaded with drug were influenced by solvent type. The drug encapsulation efficiency of caffeine was much higher than that of diclofenac sodium.

    The release rate was affected by the type of drug loaded and the particle morphology. Particles of small size released drug faster because of larger surface area and particles with a rough surface and high porosity also demonstrated an increased drug release rate. All loaded diclofenac sodium was released from the particles after 400 hours whereas only 30-50% of the loaded caffeine was released during the same time period.

  • 1167005.
    Zhang, Lechen
    Örebro University, Swedish Business School at Örebro University.
    Is Corporate CIO Role Model Applicable to Government CIO?: An Empirical Study of U.S. and U.K.2010Independent thesis Advanced level (degree of Master (One Year)), 15 credits / 22,5 HE creditsStudent thesis
  • 1167006.
    Zhang, Lechen
    et al.
    Stockholm University, Faculty of Social Sciences, Department of Computer and Systems Sciences.
    Nouri, Jalal
    Stockholm University, Faculty of Social Sciences, Department of Computer and Systems Sciences.
    A systematic review of learning and teaching with tablets2018In: 14th International Conference: Mobile Learning 2018: Proceedings / [ed] Inmaculada Arnedillo Sanchez, Pedro Isaias, Luis Rodrigues, IADIS Press, 2018, p. 79-88Conference paper (Refereed)
    Abstract [en]

    Due to the increased popularity of tablets in schools, this systematic review examines the literature on tablet-mediated learning attempting to identify how tablets support the emergence of new teaching and learning practices as well as the transformation of existing ones in primary and secondary schools. 39 studies were selected using predefined selection criteria, most of which concern natural sciences, math and language. The result identified 10 themes of pedagogical teaching and learning practices that are supported by tablets in schools, namely: augmented and virtual learning, collaborative learning, communication, documentation, feedback and assessment, game-based learning, individualized learning, inquiry-based learning, mobile learning, and multimodal learning. The identified themes of practices support and interact with each other to serve learning and teaching purposes.

  • 1167007.
    Zhang, Lechen
    et al.
    Stockholm University, Faculty of Social Sciences, Department of Computer and Systems Sciences.
    Nouri, Jalal
    Stockholm University, Faculty of Social Sciences, Department of Computer and Systems Sciences.
    Norén, Eva
    Stockholm University, Faculty of Science, Department of Mathematics and Science Education.
    Reviewing Teaching Approaches For Programming Through Scratch In Compulsory Education2018In: Clute International Conferences: Proceedings, The Clute Institute , 2018, article id 255Conference paper (Refereed)
    Abstract [en]

    As the popularity of “Computational Thinking” expands in the education realm, more and more studies have been conducted to investigate the effect of using visual programming languages, such as Scratch, to teach computational thinking. This paper provides an overview of the teaching strategies that were implemented in research studies that aimed at fostering computational thinking through Scratch in compulsory education. To do this, we examined 46 empirical studies. The analysis of these studies has led to the identification of two approaches in teaching programming through Scratch: student-centered and mixed-instruction teaching approaches. In the paper, we present different enactments of the two broad teaching strategies and discuss the implications of these.

  • 1167008.
    Zhang, Lei
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Physical Chemistry.
    Exploring Electron Transfer Dynamics of Novel Dye Sensitized Photocathodes: Towards Solar Cells and Solar Fuels2016Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The design of dyes for NiO-based dye-sensitized solar cells (DSSCs) has drawn attention owing to their potential applications in photocatalysis and because they are indispensable for the development of tandem dye-sensitized solar cells. The understanding of the electron transfer mechanisms and dynamics is beneficial to guide further dye design and further improve the performance of photocathode in solar cells and solar fuel devices.

    Time-resolved spectroscopy techniques, especially femtosecond and nanosecond transient absorption spectroscopy, supply sufficient resolution to get insights into the charge transfer processes in p-type dye sensitized solar cell and solar fuel devices. In paper I-V, several kinds of novel organic “push-pull” and inorganic charge transfer dyes for sensitization of p-type NiO, were systematically investigated by time-resolved spectroscopy, and photo-induced charge transfer dynamics of the organic/inorganic dyes were summarized. The excited state and reduced state intermediates were investigated in solution phase as references to confirm the charge injection and recombination on the NiO surface. The charge recombination kinetics is remarkably heterogeneous in some cases occurring on time scales spanning at least six orders of magnitude even for the same dye.

    In this thesis, we also proposed a novel concept of solid state p-type dye sensitized solar cells (p-ssDSSCs) for the first time (paper VI), using an organic dye P1 as sensitizer on mesoporous NiO and phenyl-C61-butyric acid methyl ester (PCBM) as electron conductor. Femtosecond and nanosecond transient absorption spectroscopy gave evidence for sub-ps hole injection from excited P1 to NiO, followed by electron transfer from P1●- to PCBM. The p-ssDSSCs device showed an impressive 620 mV open circuit photovoltage.

    Chapter 6 (paper VII) covers the study of electron transfer mechanisms in a covalently linked dye-catalyst (PB-2) sensitized NiO photocathode, towards hydrogen producing solar fuel devices. Hole injection from excited dye (PB-2*) into NiO VB takes place on dual time scales, and the reduced PB-2 (PB-2●-) formed then donates an electron to the catalyst unit.  The subsequent regeneration efficiency of PB-2 by the catalyst unit (the efficiency of catalyst reduction) is determined to ca. 70%.

  • 1167009.
    Zhang, Lei
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology.
    How Vingåkers Energetic Science Park Can Help to Strengthen Vingåker's Competitiveness2009Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Sweden and the world now face an economic crisis that is likely to accelerate the structural transformation of Sweden. Vingåker is a town in the middle of Sweden. It has ambitions to create a sustainable society by working together with enterprises and universities to develop new knowledge and technologies through the use of information technology.

    How can Vingåker become a city of world renown? There are three basic key factors - technology, talented people and education. These three factors are inseparable: the good education trains people to become talented people, these talents in turn create better technology, and the better technology achieves the best continuous interests. The Vingåker Energetic Science Park (VESP) is set up to achieve above objectives.

    By building a brand that stands for VESP is one of main idea’s to promote Vingåker. Since the Internet is the best tool to the future, for promoting the brand of Vingåker, a network platform has to be set up. The website of VESP enhanced the connection and collaboration among community, companies and universities near Vingåker region. Considering long term development of this project, promotion internationally is a key to its success. VESP is a platform that leads Vingåker to the international market and explores future opportunities.

    Field studies have been carried out on the first stage of the thesis, which include participative observation, interviews and questionnaires directed at persons at factories, companies, schools, and town hall of the community management. The results of the surveys have been analyzed and the market has been investigated. The brand has been designed and the strategies have been developed. Then the webpage of VESP was built at www.vesp.se by interaction and interface design. After usability testing, the webpage has been improved and the web promotion researched.

  • 1167010.
    Zhang, Lei
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology.
    Molecular Regulation of Vascular Abnormalization and Its Role in Glioma2015Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Glioblastoma, grade IV glioma, is the one of the deadliest cancers, with a median survival of only 12-15 months despite aggressive treatment including surgery, chemotherapy and radiation. One hallmark of glioblastoma is the morphological and functional abnormalization of tumor blood vessels. The molecular mechanisms involved in this process and their functional and pathological implications are not yet fully understood. Indentification of molecular mechanisms that underlie vascular abnormalization in GBM is necessary to develop efficient treatment regimens for normalizing vascular function.

    By analyzing the RNA-content of laser microdissected vessels from human biobank specimens using affymetrix microarray analysis, we found that the abnormal glioblastoma vessels have a distinct gene expression signature. We found 95 genes which were differentially expressed in grade IV glioma vessels as compared to vessels in low grade tumors and control brain. 78 of which were up-regulated while 17 were down-regulated. Many of these genes are regulated by VEGFA or TGFβ signaling. In addition, we show a significant increase in Smad signaling complexes in the vasculature of human glioblastoma in situ, suggesting that TGFβ signaling may play important role in vessel abnormalization.

    CD93 is a single-pass transmembrane glycoprotein, which we found to be up-regulated in high grade glioma. Vascular expression of CD93 correlates to tumor grade in human glioma. Moreover, high grade glioma patients with high CD93 expression in the vasculature are associate with poor prognosis. We found that knocking down CD93 in endothelial cells with siRNA clearly impaired endothelial cell adhesion, migration and tube formation due to defects in cytoskeletal rearrangement. In addition, tumor growth was severely delayed in the CD93-/- mice.

    Pleiotrophin, a multi-functional heparin-binding growth factor, promotes glioma growth in several ways. Here, we identify pleiotrophin as a driver of vascular abnormalization in glioma. We found that high pleiotrophin expression correlates with poor survival of patients with astrocytomas. Pleiotrophin overexpression in orthotopic GL261 gliomas increases microvessel density, enhances tumour growth and decreases survival. Vessels in pleiotrophin-expressing gliomas are poorly perfused and display a high degree of abnormality, coinciding with elevated levels of vascular endothelial growth factor (VEGF) deposited in direct proximity to the vasculature. In addition to its role in vessel abnormalization, pleiotrophin enhanced PDGF-B-induced gliomagenesis. Taken together, our results indicate that PTN has an important role in glioma initiation and establishment of the characteristic abnormal tumor vasculature in glioblastoma, identifying PTN as a potential target for therapy.

  • 1167011.
    Zhang, Lei
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Physical Chemistry.
    Boschloo, Gerrit
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Physical Chemistry.
    Hammarström, Leif
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Physical Chemistry.
    Tian, Haining
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Physical Chemistry.
    Solid state p-type dye-sensitized solar cells: concept, experiment and mechanism2016In: Physical Chemistry, Chemical Physics - PCCP, ISSN 1463-9076, E-ISSN 1463-9084, Vol. 18, no 7, p. 5080-5085Article in journal (Refereed)
    Abstract [en]

    Solid state p-type dye-sensitized solar cells (p-ssDSCs) have been proposed and fabricated for the first time, using the organic dye P1 as the sensitizer on mesoporous NiO and phenyl-C61-butyric acid methyl ester (PCBM) as the electron conductor. The p-ssDSC has shown an impressive open circuit photovoltage of 620 mV. Femtosecond and nanosecond transient absorption spectroscopy has given evidence for sub-ps hole injection from the excited P1 to NiO, followed by electron transfer from P1˙ to PCBM.

  • 1167012.
    Zhang, Lei
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Dimberg, Anna
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Vascular Biology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Pleiotrophin is a driver of vascular abnormalization in glioblastoma2016In: Molecular & Cellular Oncology, ISSN 2372-3556, Vol. 3, no 6, article id e1141087Article in journal (Refereed)
    Abstract [en]

    In a recent report by Zhang et al., pleiotrophin (PTN) was demonstrated to enhance glioma growth by promoting vascular abnormalization. PTN stimulates glioma vessels through anaplastic lymphoma kinase (Alk)-mediated perivascular deposition of vascular endothelial growth factor (VEGF). Targeting of Alk or VEGF signaling normalizes tumor vessels in PTN-expressing tumors.

  • 1167013.
    Zhang, Lei
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Physical Chemistry.
    Favereau, Ludovic
    Université de Nantes, France.
    Farre, Yoann
    Université de Nantes, France.
    Maufroy, Antoine
    Université de Nantes, France.
    Pellegrin, Yann
    Université de Nantes, France.
    Blart, Errol
    Université de Nantes, France.
    Hissler, Muriel
    Inst Sci Chim Rennes, France.
    Jacquemin, Denis
    Université de Nantes; Institut Universitaire de France.
    Odobel, Fabrice
    Université de Nantes, France.
    Hammarström, Leif
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Physical Chemistry.
    Molecular-structure control of electron transferdynamics of push–pull porphyrins as sensitizers forNiO based dye sensitized solar cells2016In: RSC Advances, ISSN 2046-2069, E-ISSN 2046-2069, Vol. 6, no 81, p. 77184-77194Article in journal (Refereed)
    Abstract [en]

    Porphyrin dyes were synthesized for use in p-type (NiO) dye sensitized solar cells based on different designprinciples. One porphyrin was designed with a significant charge transfer character in the excited statebecause of push–pull effects of the substituents. Another porphyrin had instead an appended NDIacceptor group (NDI ¼ naphthalene diimide). The dyes were characterized by spectroscopic,electrochemical and DFT methods. Solar cells based on sensitized, meso-porous NiO showed ratherpoor performance compared to other organic dyes, but with a clear improvement for the dye with theNDI acceptor. Ultrafast transient absorption spectroscopy and nanosecond laser photolysis showed thathole injection into NiO was followed by unusually rapid charge recombination, predominantly ona 50–100 ps time scale, which is likely the main reason for the poor photovoltaic performance. Againthe porphyrin with the NDI group showed a more long-lived charge separation that should lead to betterdye regeneration in a solar cell, which can explain its better photovoltaic performance.

  • 1167014.
    Zhang, Lei
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Physical Chemistry.
    Favereau, Ludovic
    Farre, Yoann
    Mijangos, Edgar
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Physical Chemistry.
    Pellegrin, Yann
    Blart, Errol
    Odobel, Fabrice
    Hammarström, Leif
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Physical Chemistry.
    Ultrafast and slow charge recombination dynamics of diketopyrrolopyrrole–NiO dye sensitized solar cells2016In: Physical Chemistry, Chemical Physics - PCCP, ISSN 1463-9076, E-ISSN 1463-9084, Vol. 18, p. 18515-18527Article in journal (Refereed)
    Abstract [en]

    In a photophysical study, two diketopyrrolopyrrole (DPP)-based sensitizers functionalized with4-thiophenecarboxylic acid as an anchoring group and a bromo (DPPBr) or dicyanovinyl (DPPCN2)group, and a dyad consisting of a DPP unit linked to a naphthalenediimide group (DPP–NDI), wereinvestigated both in solution and grafted on mesoporous NiO films. Femtosecond transient absorptionmeasurements indicate that ultrafast hole injection occurred predominantly on a timescale of B200 fs,whereas the subsequent charge recombination occurred on a surprisingly wide range of timescales,from tens of ps to tens of ms; this kinetic heterogeneity is much greater than is typically observed fordye-sensitized TiO2 or ZnO. Also, in contrast to what is typically observed for dye-sensitized TiO2, therewas no significant dependence on the excitation power of the recombination kinetics, which can beexplained by the hole density being comparatively higher near the valence band of NiO beforeexcitation. The additional acceptor group in DPP–NDI provided a rapid electron shift and stabilizedcharge separation up to the ms timescale. This enabled efficient (B95%) regeneration of NDI bya CoIII(dtb)3 electrolyte (dtb = 4,40-di-tert-butyl-2,20-bipyridine), according to transient absorptionmeasurements. The regeneration of DPPBr and DPPCN2 by CoIII(dtb)3 was instead inefficient, as mostrecombination for these dyes occurred on the sub-ns timescale. The transient spectroscopy data thuscorroborated the trend of the published photovoltaic properties of dye-sensitized solar cells (DSSCs)based on these dyes on mesoporous NiO, and show the potential of a design strategy with a secondaryacceptor bound to the dye. The study identifies rapid initial recombination between the dye and NiO asthe main obstacle to obtaining high efficiencies in NiO-based DSSCs; these recombination componentsmay be overlooked when studies are conducted using only methods with ns resolution or slower.

  • 1167015. Zhang, Lei
    et al.
    Fu, Di
    Liu, Jiangchuan
    Ngai, Edith C.-H.
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Computer Systems.
    Zhu, Wenwu
    On energy-efficient offloading in mobile cloud for real-time video applications2017In: IEEE transactions on circuits and systems for video technology (Print), ISSN 1051-8215, E-ISSN 1558-2205, Vol. 27, no 1, p. 170-181Article in journal (Refereed)
  • 1167016. Zhang, Lei
    et al.
    Hao, Jiaming
    Ye, Huapeng
    Yeo, Swee Ping
    Qiu, Min
    Zouhdi, Said
    KTH, School of Information and Communication Technology (ICT).
    Qiu, Cheng-Wei
    Theoretical realization of robust broadband transparency in ultrathin seamless nanostructures by dual blackbodies for near infrared light2013In: Nanoscale, ISSN 2040-3364, E-ISSN 2040-3372, Vol. 5, no 8, p. 3373-3379Article in journal (Refereed)
    Abstract [en]

    We propose a counter-intuitive mechanism of constructing an ultrathin broadband transparent device with two perfect blackbodies. By introducing hybridization of plasmon modes, resonant modes with different symmetries coexist in this system. A broadband transmission spectrum in the near infrared regime is achieved through controlling their coupling strengths, which is governed by the thickness of high refractive index layer. Meanwhile, the transparency bandwidth is found to be tunable in a large range by varying the geometric dimension. More significantly, from the point view of applications, the proposed method of achieving broadband transparency can perfectly tolerate the misalignment and asymmetry of periodic nanoparticles on the top and bottom, which is empowered by the unique dual of coupling-in and coupling-out processes within the pair of blackbodies. Moreover, roughness has little influence on its transmission performance. According to the coupled mode theory, the distinguished transmittance performance is physically interpreted by the radiative decay rate of the entire system. In addition to the feature of uniquely robust broadband transparency, such a ultrathin seamless nanostructure ( in the presence of a uniform silver layer) also provides polarization-independent and angle-independent operations. Therefore, it may power up a wide spectrum of exciting applications in thin film protection, touch screen techniques, absorber-emitter transformation, etc.

  • 1167017.
    Zhang, Lei
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Vascular Biology. Uppsala University, Science for Life Laboratory, SciLifeLab. Shaanxi Normal Univ, Natl Engn Lab Resource Developing Endangered Chin, Coll Life Sci, Key Lab, Minist Educ Med Plant Resource & Nat Phar, Xian, Shaanxi, Peoples R China.
    He, Liqun
    Tianjin Med Univ Gen Hosp, Key Lab Postneuroinjury Neurorepair & Regenerat C, Tianjin Neurol Inst, Dept Neurosurg, Minist Educ & Tianjin City, Tianjin, Peoples R China.
    Lugano, Roberta
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Vascular Biology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Roodakker, Kenney Roy
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neurology.
    Bergqvist, Michael
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Research and Development, Gävleborg. Umeå Univ Hosp, Dept Radiat Sci & Oncol, Umeå, Sweden.
    Smits, Anja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neurology.
    Dimberg, Anna
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Vascular Biology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    IDH mutation status is associated with distinct vascular gene expression signatures in lower-grade gliomas2018In: Neuro-Oncology, ISSN 1522-8517, E-ISSN 1523-5866, Vol. 20, no 11, p. 1505-1516Article in journal (Refereed)
    Abstract [en]

    Background: Vascular gene expression patterns in lower-grade gliomas (LGGs; diffuse World Health Organization [WHO] grades II–III gliomas) have not been thoroughly investigated. The aim of this study was to molecularly characterize LGG vessels and determine if tumor isocitrate dehydrogenase (IDH) mutation status affects vascular phenotype.

    Methods: Gene expression was analyzed using an in-house dataset derived from microdissected vessels and total tumor samples from human glioma in combination with expression data from 289 LGG samples available in the database of The Cancer Genome Atlas. Vascular protein expression was examined by immunohistochemistry in human brain tumor tissue microarrays (TMAs) representing WHO grades II–IV gliomas and nonmalignant brain samples. Regulation of gene expression was examined in primary endothelial cells in vitro.

    Results: Gene expression analysis of WHO grade II glioma indicated an intermediate stage of vascular abnormality, less severe than that of glioblastoma vessels but distinct from normal vessels. Enhanced expression of laminin subunit alpha 4 (LAMA4) and angiopoietin 2 (ANGPT2) in WHO grade II glioma was confirmed by staining of human TMAs. IDH wild-type LGGs displayed a specific angiogenic gene expression signature, including upregulation of ANGPT2 and serpin family H (SERPINH1), connected to enhanced endothelial cell migration and matrix remodeling. Transcription factor analysis indicated increased transforming growth factor beta (TGFβ) and hypoxia signaling in IDH wild-type LGGs. A subset of genes specifically induced in IDH wild-type LGG vessels was upregulated by stimulation of endothelial cells with TGFβ2, vascular endothelial growth factor, or cobalt chloride in vitro.

    Conclusion: IDH wild-type LGG vessels are molecularly distinct from the vasculature of IDH-mutated LGGs. TGFβ and hypoxia-related signaling pathways may be potential targets for anti-angiogenic therapy of IDH wild-type LGG.

  • 1167018. Zhang, Lei
    et al.
    Kundu, Soumi
    Feenstra, Tjerk
    Li, Xiujuan
    Jin, Chuan
    Elsir, Tamador
    Ohlin, K. Elisabet
    Yu, Di
    Olofsson, Tommie
    Olsson, Anna-Karin
    Pontén, Fredrik
    Magnusson, Peetra U.
    Forsberg Nilsson, Karin
    Essand, Magnus
    Smits, Anja
    Dieterich, Lothar C.
    Dimberg, Anna
    Pleiotrophin promotes vascular abnormalization in glioma and correlates withpoor survival in human astrocytomasArticle in journal (Other academic)
  • 1167019.
    Zhang, Lei
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Vascular Biology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Kundu, Soumi
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Neuro-Oncology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Feenstra, Tjerk
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Li, Xiujuan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Jin, Chuan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Laaniste, Liisi
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    El Hassan, Tamador Elsir Abu
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neurology.
    Ohlin, K Elisabet
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Vascular Biology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Yu, Di
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Olofsson, Tommie
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Olsson, Anna-Karin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Pontén, Fredrik
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Molecular and Morphological Pathology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Magnusson, Peetra U
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Forsberg, Karin Nilsson
    Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Neuro-Oncology.
    Essand, Magnus
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Smits, Anja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neurology.
    Dieterich, Lothar C
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Dimberg, Anna
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Vascular Biology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Pleiotrophin promotes vascular abnormalization in gliomas and correlates with poor survival in patients with astrocytomas.2015In: Science Signaling, ISSN 1945-0877, E-ISSN 1937-9145, Vol. 8, no 406Article in journal (Refereed)
    Abstract [en]

    Glioblastomas are aggressive astrocytomas characterized by endothelial cell proliferation and abnormal vasculature, which can cause brain edema and increase patient morbidity. We identified the heparin-binding cytokine pleiotrophin as a driver of vascular abnormalization in glioma. Pleiotrophin abundance was greater in high-grade human astrocytomas and correlated with poor survival. Anaplastic lymphoma kinase (ALK), which is a receptor that is activated by pleiotrophin, was present in mural cells associated with abnormal vessels. Orthotopically implanted gliomas formed from GL261 cells that were engineered to produce pleiotrophin showed increased microvessel density and enhanced tumor growth compared with gliomas formed from control GL261 cells. The survival of mice with pleiotrophin-producing gliomas was shorter than that of mice with gliomas that did not produce pleiotrophin. Vessels in pleiotrophin-producing gliomas were poorly perfused and abnormal, a phenotype that was associated with increased deposition of vascular endothelial growth factor (VEGF) in direct proximity to the vasculature. The growth of pleiotrophin-producing GL261 gliomas was inhibited by treatment with the ALK inhibitor crizotinib, the ALK inhibitor ceritinib, or the VEGF receptor inhibitor cediranib, whereas control GL261 tumors did not respond to either inhibitor. Our findings link pleiotrophin abundance in gliomas with survival in humans and mice, and show that pleiotrophin promotes glioma progression through increased VEGF deposition and vascular abnormalization.

  • 1167020.
    Zhang, Lei
    et al.
    Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Vascular Biology.
    Laaniste, Liisi
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology. Uppsala University, Science for Life Laboratory, SciLifeLab. Imperial Coll, Fac Med, Div Brain Sci, London, England..
    Jiang, Yiwen
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Neuro-Oncology. Uppsala University, Science for Life Laboratory, SciLifeLab. Karolinska Inst, Dept Mol Biochem & Biophys, Solna, Sweden..
    Alafuzoff, Irina
    Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical and experimental pathology.
    Uhrbom, Lene
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Neuro-Oncology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Dimberg, Anna
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Vascular Biology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Pleiotrophin enhances PDGFB-induced gliomagenesis through increased proliferation of neural progenitor cells2016In: OncoTarget, ISSN 1949-2553, E-ISSN 1949-2553, Vol. 7, no 49, p. 80382-80390Article in journal (Refereed)
    Abstract [en]

    Pleiotrophin (PTN) augments tumor growth by increasing proliferation of tumor cells and promoting vascular abnormalization, but its role in early gliomagenesis has not been evaluated. Through analysis of publically available datasets, we demonstrate that increased PTN mRNA expression is associated with amplification of chromosome 7, identified as one of the earliest steps in glioblastoma development. To elucidate the role of PTN in tumor initiation we employed the RCAS/tv-a model that allows glioma induction by RCAS-virus mediated expression of oncogenes in neural progenitor cells. Intracranial injection of RCAS-PTN did not induce glioma formation when administrated alone, but significantly enhanced RCAS-platelet derived growth factor (PDGF) B-induced gliomagenesis. PTN co-treatment augmented PDGFBinduced Akt activation in neural progenitor cells in vitro, and enhanced neural sphere size associated with increased proliferation. Our data indicates that PTN expression is associated with chromosome 7 gain, and that PTN enhances PDGFB-induced gliomagenesis by stimulating proliferation of neural progenitor cells.

  • 1167021. Zhang, Lei
    et al.
    Laaniste, Liisi
    Jiang, Yiwen
    Uhrbom, Lene
    Dimberg, Anna
    Pleiotrophin enhances PDGF-B-induced gliomagenesis and promotesangiogenesis in high-grade tumors in mouse experimental gliomaManuscript (preprint) (Other academic)
  • 1167022. Zhang, Lei
    et al.
    Qiao, Qing
    Laatikainen, Tiina
    Söderberg, Stefan
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine.
    Jousilahti, Pekka
    Onat, Altan
    Nilsson, Peter
    Tuomilehto, Jaakko
    The impact of dyslipidaemia on incidence of coronary heart disease in Finns and Swedes with different categories of glucose tolerance2011In: Diabetes Research and Clinical Practice, ISSN 0168-8227, E-ISSN 1872-8227, Vol. 91, no 3, p. 406-412Article in journal (Refereed)
    Abstract [en]

    Background: The association of dyslipidaemia with incidence of coronary heart disease (CHD) has not been well studied in people with different glucose categories.

    Methods: Data from six population-based prospective studies in Finland and Sweden, with 4818 men and 4269 women aged 25–89 years who were free of CHD and without a prior history of diabetes at baseline, were jointly analysed. Multivariate-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for CHD incidence were estimated.

    Results: 457 participants developed CHD during follow-up of 10 years. The multivariate adjusted HRs (95% CIs) for CHD incidence were 1.39 (1.08–1.80), 0.57 (0.39–0.84), 1.21 (1.07–1.37), 1.56 (1.21–2.01) and 1.74 (1.34–2.26), respectively, corresponding to a one unit increase in Z-scores of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), non-HDL-C and TC to HDL ratio, in people with newly diagnosed diabetes. The prediction was also significant in non-diabetic population except for TG in individuals with normoglycaemia and TG and HDL-C in those with isolated IFG.

    Conclusion: Adverse lipid profiles were related to increased CHD incidence in normoglycaemic, fasting hyperglycaemic and diabetic individuals, but not in people with IGT. The findings may imply considering different management strategies in people with fasting or post-load hyperglycaemia.

  • 1167023. Zhang, Lei
    et al.
    Qiao, Qing
    Tuomilehto, Jaakko
    Hammar, Niklas
    Ruotolo, Giacomo
    Stehouwer, Coen D A
    Heine, Robert J
    Eliasson, Mats
    Zethelius, Björn
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.
    The impact of dyslipidaemia on cardiovascular mortality in individuals without a prior history of diabetes in the DECODE Study2009In: Atherosclerosis, ISSN 0021-9150, E-ISSN 1879-1484, Vol. 206, no 1, p. 298-302Article in journal (Refereed)
    Abstract [en]

    OBJECTIVE: To evaluate the impact of dyslipidaemia on cardiovascular disease (CVD) mortality in relation to fasting (FPG) and 2-h (2hPG) plasma glucose levels in individuals without a prior history of diabetes. METHODS: Data from 14 European population-based prospective studies of 9132 men and 8631 women aged 25-89 years were jointly analysed. A total of 871 CVD deaths occurred during the average 10 years of follow-up. Subjects were classified into normoglycaemia, isolated fasting hyperglycaemia (IFH, FPG>/=6.10mmol/l and 2hPG<7.80mmol/l), isolated post-load hyperglycaemia (IPH, FPG<6.10mmol/l and 2hPG>/=7.80mmol/l) and combined fasting and post-load hyperglycaemia (CH, FPG>/=6.10mmol/l and 2hPG>/=7.80mmol/l). Multivariate-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for CVD mortality were estimated using Cox proportional hazard analysis. RESULTS: Multivariate-adjusted HRs (95% CIs) for high-density lipoprotein cholesterol (HDL-C) were 0.84 (0.75-0.94), 0.66 (0.48-0.92), 1.03 (0.84-1.27) and 0.67 (0.51-0.89) in individuals with normoglycaemia, IFH, IPH and CH, respectively. For total cholesterol (TC) to HDL-C ratio they were 1.14 (1.03-1.27), 1.44 (1.13-1.84), 0.94 (0.77-1.15) and 1.26 (1.05-1.50), respectively. HRs for TC and triglycerides (TG) were not significant in most of the glucose categories except for TG in those with CH [HR 1.12 (1.00-1.27)]. CONCLUSIONS: Low HDL-C and high TC/HDL-C increase CVD mortality in either diabetic or non-diabetic individuals defined based on the fasting glucose criteria, but not the 2-h criteria. TG is a significant CVD risk predictor only in the presence of combined hyperglycaemia or diabetes. The difference between fasting and post-load hyperglycaemia with regard to the lipid-CVD relation may suggest a different pathophysiology underlying these two prediabetic states.

  • 1167024. Zhang, Lei
    et al.
    Qiao, Qing
    Tuomilehto, Jaakko
    Hammar, Niklas
    Ruotolo, Giacomo
    Stehouwer, Coen D A
    Heine, Robert J
    Eliasson, Mats
    Umeå University, Faculty of Medicine, Public Health and Clinical Medicine, Medicine.
    Zethelius, Björn
    The impact of dyslipidaemia on cardiovascular mortality in individuals without a prior history of diabetes in the DECODE Study.2009In: Atherosclerosis, ISSN 0021-9150, E-ISSN 1879-1484, Vol. 206, no 1, p. 298-302Article in journal (Refereed)
    Abstract [en]

    OBJECTIVE: To evaluate the impact of dyslipidaemia on cardiovascular disease (CVD) mortality in relation to fasting (FPG) and 2-h (2hPG) plasma glucose levels in individuals without a prior history of diabetes. METHODS: Data from 14 European population-based prospective studies of 9132 men and 8631 women aged 25-89 years were jointly analysed. A total of 871 CVD deaths occurred during the average 10 years of follow-up. Subjects were classified into normoglycaemia, isolated fasting hyperglycaemia (IFH, FPG> or =6.10 mmol/l and 2hPG<7.80 mmol/l), isolated post-load hyperglycaemia (IPH, FPG<6.10 mmol/l and 2hPG> or =7.80 mmol/l) and combined fasting and post-load hyperglycaemia (CH, FPG> or =6.10 mmol/l and 2hPG> or =7.80 mmol/l). Multivariate-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for CVD mortality were estimated using Cox proportional hazard analysis. RESULTS: Multivariate-adjusted HRs (95% CIs) for high-density lipoprotein cholesterol (HDL-C) were 0.84 (0.75-0.94), 0.66 (0.48-0.92), 1.03 (0.84-1.27) and 0.67 (0.51-0.89) in individuals with normoglycaemia, IFH, IPH and CH, respectively. For total cholesterol (TC) to HDL-C ratio they were 1.14 (1.03-1.27), 1.44 (1.13-1.84), 0.94 (0.77-1.15) and 1.26 (1.05-1.50), respectively. HRs for TC and triglycerides (TG) were not significant in most of the glucose categories except for TG in those with CH [HR 1.12 (1.00-1.27)]. CONCLUSIONS: Low HDL-C and high TC/HDL-C increase CVD mortality in either diabetic or non-diabetic individuals defined based on the fasting glucose criteria, but not the 2-h criteria. TG is a significant CVD risk predictor only in the presence of combined hyperglycaemia or diabetes. The difference between fasting and post-load hyperglycaemia with regard to the lipid-CVD relation may suggest a different pathophysiology underlying these two prediabetic states.

  • 1167025.
    Zhang, Lei
    et al.
    Department of Public Health, University of Helsinki, FIN-00014 Helsinki, Finland.
    Qiao, Qing
    Department of Public Health, University of Helsinki, FIN-00014 Helsinki, Finland.
    Tuomilehto, Jaakko
    Department of Public Health, University of Helsinki, FIN-00014 Helsinki, Finland.
    Janus, Edward D
    Department of Medicine, University of Melbourne, Western Hospital, Footscray, VIC 3011, Australia.
    Lam, Tai Hing
    Department of Community Medicine, School of Public Health, University of Hong Kong, Hong Kong, China.
    Ramachandran, Ambady
    India Diabetes Research Foundation and Dr. A. Ramachandran’s Diabetes Hospitals, Egmore, Chennai 600 008, India.
    Mohan, Viswanathan
    Madras Diabetes Research Foundation and Dr. Mohan’s Diabetes Specialities Centre, Chennai 600 086, India.
    Stehouwer, Coen D A
    Department of Internal Medicine and Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, 6202 AZ Maastricht, The Netherlands.
    Dong, Yanhu
    Qingdao Endocrinology and Diabetes Hospital and Institute, 266071 Qingdao, China.
    Nakagami, Tomoko
    Diabetes Center, Tokyo Women’s Medical University School of Medicine, 162-8666 Tokyo, Japan.
    Onat, Altan
    Turkish Society of Cardiology, Istanbul University, Istanbul 34452, Turkey.
    Söderberg, Stefan
    Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine.
    Distinct ethnic differences in lipid profiles across glucose categories2010In: Journal of Clinical Endocrinology and Metabolism, ISSN 0021-972X, E-ISSN 1945-7197, Vol. 95, no 4, p. 1793-1801Article in journal (Refereed)
    Abstract [en]

    Context: Dyslipidemia coexists with hyperglycemia. However, little is known about the ethnic differences in lipid profiles at comparable glucose tolerance status.

    Objective: The aim was to study ethnic differences in lipid profiles stratified by glucose levels.

    Design and Setting: Data from 31 study cohorts of 12 countries, consisting of 24,760 men and 27,595 women aged 25–74 yr, were compared. The odds ratio for having dyslipidemia was estimated for each ethnic group stratified by glucose categories.

    Results: Compared with central and northern Europeans, multivariable adjusted odds ratios (95% confidence intervals) for having lower high-density lipoprotein-cholesterol were 4.74 (4.19–5.37), 5.05 (3.88–6.56), 3.07 (2.15–4.40), and 2.37 (1.67–3.35) in Asian Indian men, but 0.12 (0.09–0.16), 0.07 (0.04–0.13), 0.11 (0.07–0.20), and 0.16 (0.08–0.32) in Chinese men who had normoglycemia, prediabetes, and undiagnosed and diagnosed diabetes, respectively. Similar results were obtained for women. The prevalence of low high-density lipoprotein-cholesterol remained higher in Asian Indians (62.8% of the nondiabetic and 67.4% of the diabetic) than in central and northern Europeans (20.3 and 37.3%), Japanese (25.7 and 34.1%), or Qingdao Chinese (15.7 and 17.0%), even in individuals with low-density lipoprotein-cholesterol of less than 3 mmol/liter.

    Conclusion: There are distinct patterns of lipid profiles associated with ethnicity regardless of the glucose levels, suggesting that ethnic-specific strategies and guidelines on risk assessment and prevention of cardiovascular disease are required.

  • 1167026.
    ZHANG, LEI
    et al.
    Dalarna University, School of Technology and Business Studies, Economics.
    YOU, XI
    Dalarna University, School of Technology and Business Studies, Economics.
    The Choice of STIGA Table Tennis Blades: Evidence from China2010Independent thesis Basic level (degree of Bachelor)Student thesis
    Abstract [en]

    The purpose of this paper is to investigate how individuals with different characteristics make their choice-decisions when consuming STIGA table tennis blades, which are combinations of various attributes, such as price, control, attack, etc. It is expected that the general trend of choice behavior on this special commodity can be, at least to some extent, revealed. Data were collected using questionnaires sent to registered members of a table tennis club in China. The questionnaires included information and questions about individuals’ monthly income levels, ages, technique styles, etc. A multinomial logit model was then applied to analyze factors determining Chinese consumers’ choice behavior on STIGA table tennis blades. The results indicated that the main element influencing Chinese consumers’ choice of STIGA ping-pong blades was the technique style and other variables did not seem to influence the choice of table tennis blades. These results might be explained by the limited sample size as well as unmeasured and immeasurable factors. Thus, a more extensive research is needed to be conducted in the future.

  • 1167027.
    Zhang, Lei
    et al.
    Tianjin University, China.
    Zhang, Keqiang
    Ministry of Agriculture, China.
    Gao, Wenxuan
    Ministry of Agriculture, China.
    Zhai, Zhongwei
    Ministry of Agriculture, China.
    Liang, Junfeng
    Ministry of Agriculture, China.
    Du, Lianzhu
    Ministry of Agriculture, China.
    Feng, Xinmei
    RISE, SP – Sveriges Tekniska Forskningsinstitut, JTI Institutet för Jordbruks- och Miljöteknik.
    Influence of temperature and pH on methanogenic digestion in two-phase anaerobic co-digestion of pig manure with maize straw2016In: Journal of Residuals Science and Technology, ISSN 1544-8053, E-ISSN 2376-578X, Vol. 13, p. 27-32Article in journal (Refereed)
    Abstract [en]

    The objective of this work was to investigate the performance and archaeal community of methanogenic digester under different temperatures (35°C, 55°C) and pH values (6.5, 7.0, 7.5, 8.0 and 8.5) in two-phase anaerobic digestion of pig manure and maize straw. The specific CH4 yields decreased by 22.6%, 60.0% and 94.1% for pH 7.5, 8.0 and 8.5 compared with pH 7.0 (277 N mLg-1CODadd) at 35°C, and decreased by 31.6%, 70.9% and 95.0% compared with pH 7.0 (253 N mLg-1CODadd) at 55°C The methane productions of mesophilic digestion at five pH levels were 13.6%, 9.7%, 24.1%, 50.8% and 30.0% higher than that of thermophilic digestion. Terminal restriction fragment length polymorphism (T-RFLP) analyses combined with clone library indicated that Methanosaeta and Methanosarcina were the dominant genus at 35°C and 55°C, respectively, and the relative abundance decreased significantly with the pH increasing from 7.5 to 8.5.

  • 1167028.
    Zhang, Lei-Qing
    et al.
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Virology.
    Mei, Ya-Fang
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Virology.
    Wadell, Göran
    Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Virology.
    Human adenovirus serotypes 4 and 11 show higher binding affinity and infectivity for endothelial and carcinoma cell lines than serotype 52003In: Journal of General Virology, ISSN 0022-1317, E-ISSN 1465-2099, Vol. 84, no 3, p. 687-695Article in journal (Refereed)
    Abstract [en]

    Adenoviruses are promising vectors for human cancer gene therapy. However, the extensively used adenoviruses serotypes 2 and 5 (Ad2 and Ad5) from species C have a major disadvantage in being highly prevalent; thus, most adults have an immunity against the two viruses. Furthermore, the expression of coxsackievirus and adenovirus receptors for Ad2 and Ad5 varies in different cells. This study aims to identify adenovirus serotypes with specific tropism for endothelial cells and epithelial tumour cells. Comparison of the binding affinities of Ad31, Ad11, Ad5, Ad37, Ad4 and Ad41, belonging to species A-F, respectively, to established cell lines of hepatoma (HepG2), breast cancer (CAMA and MG7), prostatic cancer (DU145 and LNCaP) and laryngeal cancer (Hep2), as well as to endothelial cells (HMEC), was carried out by flow cytometric analysis. Ad11 from species B showed markedly higher binding affinity than Ad5 for the endothelial cell line and all carcinoma cell lines studied. Ad4 showed a specific binding affinity for hepatoma cells and laryneal carcinoma cells. The ability of Ad11, Ad4 and Ad5 to be expressed in hepatoma, breast cancer and endothelial cell lines was studied by immunostaining and (35)S-labelling of viral proteins in infected cells. Ad11 and Ad4 manifested a higher proportion of infected cells and a higher degree of hexon expression than Ad5.

  • 1167029.
    Zhang, Li
    Philosophy and History, KTH, School of Architecture and the Built Environment (ABE), Philosophy and History of Technology, Philosophy.
    Believability relations for select-direct sentential revision2017In: Studia Logica: An International Journal for Symbolic Logic, ISSN 0039-3215, E-ISSN 1572-8730, Vol. 105, no 1, p. 37-63Article in journal (Refereed)
    Abstract [en]

    A set of sentential revision operations can be generated in a select-direct way within a new framework for belief change named descriptor revision firstly introduced in Hansson [8]. In this paper, we adopt another constructive approach to these operations, based on a relation <= on sentences named believability relation. Intuitively,phi <= psi means that the subject is at least as prone to believe or accept phi as to believe or accept . We demonstrate that so called H-believability relations and basic believability relations, the second of which the is axiomatically characterized with a set of weak postulates, are faithful alternative models for two typical select-direct sentential revision operations. Then we investigate additional postulates on believability relations that correlate with properties of the generated revision operations. Finally, we show that traditional AGM revision operations can be reconstructed from a strengthened variant of the basic believability relation and there is a close connection between this relation and the standard epistemic entrenchment relation.

  • 1167030.
    Zhang, Li
    Philosophy and History, KTH, School of Architecture and the Built Environment (ABE), Philosophy and History of Technology, Philosophy.
    Choice revisionManuscript (preprint) (Other academic)
    Abstract [en]

    Choice revision is a sort of non-prioritized multiple revision, in which the agent partially accepts the new information represented by a set of sentences. We investigate the construction of choice revision based on a new approach to belief change called descriptor revision. We prove that each of two variants of choice revision based on such construction is axiomatically characterized with a set of plausible postulates, assuming that the object language is finite. Furthermore, we introduce an alternative modelling for choice revision, which is based on a type of relation on sets of sentences, named multiple believability relation. We show without assuming a finite language that choice revision constructed from such relations is axiomatically characterized with the same sets of postulates proposed for the choice revision based on descriptor revision, whenever the relations satisfy certain rationality conditions.

  • 1167031.
    Zhang, Li
    Philosophy and History, KTH, School of Architecture and the Built Environment (ABE), Philosophy and History of Technology, Philosophy.
    Choice revision on belief basesManuscript (preprint) (Other academic)
    Abstract [en]

    In this contribution we explore choice revision, a sort of belief change in which the new information is represented by a set of sentences and the agent could accept some of the sentences while rejecting the others. We propose a generalized version of expansion operation called partial expansion for developing models of choice revision. By using the partial expansion and two multiple contraction operations previously introduced in the literature, we construct two kinds of choice revision on belief bases. For each of them we propose a set of postulates and prove a partial or full representation theorem. Furthermore, we investigate the operations of making up one's mind derived from these two kinds of choice revision and also give the associated representation theorems.

  • 1167032.
    Zhang, Li
    Philosophy and History, KTH, School of Architecture and the Built Environment (ABE), Philosophy and History of Technology, Philosophy.
    On Non-Prioritized Multiple Belief Revision2018Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    This thesis investigates a sort of non-prioritized multiple revision, the operation of making up one's mind, and its generalization, the operation of choice revision. Making up one's mind about a sentence is a belief change that takes the agent to a belief state in which either the sentence or its negation is believed. In choice revision, the input information is represented by a set of sentences, and the agent should make a choice on which sentences to be accepted. Apart from being practically important, these operations are technically interesting since the standard approach of intersecting a set of optimal outcomes is not workable.

    Paper I provides a construction based on descriptor revision in which the operation of making up one's mind can be modelled in a ``select-direct'' way, which is different from the traditional ``select-and-intersect'' methodology employed in the AGM model. The article shows that this construction is axiomatically characterized with a set of plausible postulates, and investigates the additional postulates that correlate with properties of the construction.

    Paper II investigates a new modelling for sentential belief revision operations, which is based on a set of relations on sentences named believability relations. It demonstrates that two special kinds of such relations, i.e. H-believability relations and basic believability relations, are faithful alternative models of two typical sentential revision generated from descriptor revision. It also shows that traditional AGM revision operations can be reconstructed from a strengthened variant of the basic believability relation and there exists a close connection between this strengthened believability relation and the standard epistemic entrenchment relation.

    Paper III studies the constructions of choice revision based on descriptor revision and multiple believability relations, which extends the domain of believability relations from sentences to sets of sentences. It is shown that each of two variants of choice revision based on descriptor revision is axiomatically characterized with a set of plausible postulates, assuming that the object language is finite. Furthermore, without assuming a finite language, it is shown that choice revision constructed from multiple believability relations is axiomatically characterized with the same sets of postulates proposed for choice revision derived from descriptor revision, whenever these relations satisfy certain rationality conditions.

    Paper IV explores choice revision on belief bases. A generalized version of expansion operation called partial expansion is introduced for developing models of this kind of choice revision. Based on the partial expansion as well as two multiple contraction operations from the literature, two kinds of choice revision operators on belief bases are constructed. This paper proposes several postulates for such two operators and shows that they can be axiomatically characterized by such postulates. Furthermore, it investigates two kinds of making up one's mind operators generated from these two choice revision operators and presents the axiomatic characterizations of them.

  • 1167033.
    Zhang, Li
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Statistics.
    Wind Speed Modeling under the Assumption of the Weibull distribution2010Independent thesis Advanced level (degree of Master (Two Years)), 30 credits / 45 HE creditsStudent thesis
    Abstract [en]

    Wind power economy is considered to be and has become a very promising hope for the clean energy in the future. People tend to find the correct model under proper assumption to describe the attributes of wind speed at a certain location. In this paper, I try to explore the relation between horizontal wind speed and the corresponding height, using the data measured by a SODAR device, the AQS system and obtained from the day 17th Nov 2009 to 10th Jan 2010. Quadratic and cubic functions are chosen to fit the data and the model estimation will be under the assumption of the Normal or Weibull distribution. All the coefficient estimation of the model calculated by MLE or GLM method will be compared by Bootstrap t-test. In the end, I will use the Chi-square test to find which distribution fits the data better.

  • 1167034.
    Zhang, Li
    et al.
    Tsinghua Univ, Dept Construct Management, Hang Lung Ctr Real Estate, Beijing, Peoples R China..
    Chen, Jie
    Shanghai Univ Finance & Econ, Inst Real Estate Res, Shanghai, Peoples R China.;Shanghai Univ Finance & Econ, Sch Publ Econ & Adm, Shanghai, Peoples R China..
    Hao, Qianjin
    Fudan Univ, Dept Environm Sci & Engn, Shanghai, Peoples R China..
    Li, Chuan-Zhong
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Economics. Royal Swedish Acad Sci, Beijer Inst, Stockholm, Sweden..
    Measuring the NIMBY effect in urban China: the case of waste transfer stations in metropolis Shanghai2018In: Journal of Housing and the Built Environment, ISSN 1566-4910, E-ISSN 1573-7772, Vol. 33, no 1, p. 1-18Article in journal (Refereed)
    Abstract [en]

    China is experiencing fast urbanization and its urban citizens' growing concern for urban disamenity has imposed a serious challenge for the urban management. This paper assesses the impact of a typical environmental facility, namely waste transfer stations, on housing values in Shanghai, China. Through hedonic pricing models, we detect an inverted-U pattern of housing prices around the waste transfer stations in Shanghai, and the maximum influence distance is nearly 3 km. We also analyze how the disamenity impacts of waste transfer stations vary across locations and differ with their own characteristics. The possibility of neighborhood sorting is discussed, but we find it would not be a problem in this paper. In the conclusion section, we discuss the policy implications of our findings.

  • 1167035.
    Zhang, Li
    et al.
    KTH, School of Architecture and the Built Environment (ABE), Philosophy and History of Technology, Philosophy.
    Hansson, Sven Ove
    KTH, School of Architecture and the Built Environment (ABE), Philosophy and History of Technology, Philosophy.
    How to make up one's mind2015In: Logic journal of the IGPL (Print), ISSN 1367-0751, E-ISSN 1368-9894, Vol. 23, no 4, p. 705-717Article in journal (Refereed)
    Abstract [en]

    The operation of making up one's mind about a sentence phi is a belief change operation that takes the agent to a belief state in which either phi or phi is believed. Apart from being practically important, this operation is technically interesting since the standard approach of intersecting a set of optimal outcomes is not workable. A construction based on descriptor revision is provided in which the operation can be modelled. This construction is axiomatically characterized with a set of plausible postulates, and additional postulates that correlate with properties of the construction are investigated.

  • 1167036.
    Zhang, Li
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Structure and Molecular Biology.
    Jiang, Wangshu
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Structure and Molecular Biology.
    Nan, Jie
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology.
    Almqvist, Jonas
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Structure and Molecular Biology.
    Huang, Yafei
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology.
    The Escherichia coli CysZ is a pH dependent sulfate transporter that can be inhibited by sulfite2014In: Biochimica et Biophysica Acta - Biomembranes, ISSN 0005-2736, E-ISSN 1879-2642, Vol. 1838, no 7, p. 1809-1816Article in journal (Refereed)
    Abstract [en]

    The Escherichia coli inner membrane protein CysZ mediates the sulfate uptake subsequently utilized for the synthesis of sulfur-containing compounds in cells. Here we report the purification and functional characterization of CysZ. Using Isothermal Titration Calorimetry, we have observed interactions between CysZ and its putative substrate sulfate. Additional sulfur-containing compounds from the cysteine synthesis pathway have also been analyzed for their abilities to interact with CysZ. Our results suggest that CysZ is dedicated to a specific pathway that assimilates sulfate for the synthesis of cysteine. Sulfate uptake via CysZ into E. coil whole cells and proteoliposome offers direct evidence of CysZ being able to mediate sulfate uptake. In addition, the cysteine synthesis pathway intermediate sulfite can interact directly with CysZ with higher affinity than sulfate. The sulfate transport activity is inhibited in the presence of sulfite, suggesting the existence of a feedback inhibition mechanism in which sulfite regulates sulfate uptake by CysZ. Sulfate uptake assays performed at different extracellular pH and in the presence of a proton uncoupler indicate that this uptake is driven by the proton gradient. (C) 2014 Elsevier B.V. All rights reserved.

  • 1167037.
    Zhang, Li
    et al.
    University of Gävle, Faculty of Engineering and Sustainable Development, Department of Industrial Development, IT and Land Management.
    Kong, Yanjun
    University of Gävle, Faculty of Engineering and Sustainable Development, Department of Industrial Development, IT and Land Management.
    Outlining benefits and barriers for employing four types of information system in fourth-party logistics2014Independent thesis Advanced level (degree of Master (One Year)), 40 credits / 60 HE creditsStudent thesis
    Abstract [en]

    This paper examines the process of employing four kinds of information systems in fourth-party logistics. The paper mainly tries to answer research questions: what is fourth-party logistics and information systems; what are benefits and barriers for using four kinds of information systems (RFID, WMS, EDI, Electronic marketplace) with the help of fourth-party logistics; what are unique benefits and barriers for fourth-party logistics to employ the four kinds of information systems and how to overcome the difficulties. To answer the research question, qualitative case study approach was employed and two case companies were chosen. Information in literature review was collected from secondary data for example scientific paper. Information in findings was collected from interviews of people in charge of the project and internal reports.

     

    Definitions of fourth-party logistics and information system were reviewed in literature review. The differences between fourth-party logistics and third-party logistics were presented as well. In addition, categorization of various kinds of advanced information systems was also listed.

     

    Benefits and barriers organized from literature and case studies were gathered and compared in discussion. Two significant benefits were identified: opportunities to do businesses with leading companies and improved efficiency. Two main barriers are confusion of the concept of fourth-party logistics and terminology of information system and financial justification. There are different opinions between the two case companies, literature review and empirical data, and between different literature. The paper concluded that there are many benefits and barriers for employing the four kinds of information systems in fourth-party logistics, and the future development of it is promising.

  • 1167038.
    Zhang, Li
    et al.
    University of Gävle, Faculty of Engineering and Sustainable Development, Department of Industrial Development, IT and Land Management.
    Ren, Xi
    University of Gävle, Faculty of Engineering and Sustainable Development, Department of Industrial Development, IT and Land Management.
    A two-factor evaluation of bus delays based on GIS-T database and simulation2010Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    During the urbanization process, vehicles quantity increase with expansion in population. Under this situation, bus transportation system also suffers from bus delay. Bus delay could be caused by a series of factors, for instance, overload passengers, traffic jam, traffic accident and other unpredictable situations. Therefore, choosing crucial elements to efficiently evaluate bus delay is a complex problem in bus delay researches and operation management. The thesis propose an approach to evaluate and explain bus delay by two elements: traffic congestion and passengers’ waiting time. Those two elements would represent the action of external and internal factors on bus operation. This approach could be adaptive to explain the reasons for bus delays, thus to help the optimization of bus lines and give useful information for decision making of transportation company. To achieve the research aim, a GIS-T database was created by combining the GIS database and TIS database. Spatial data as well as attribute data are combined in the database to represent the crucial information for bus delay. Based on GIS-T the database, the impact of traffic congestion and passengers’ waiting time was calculated using the bus line simulation. By implementing the above steps, the main cause of bus delay was studied. A case study application of this method is narrated; focusing on optimize the bus system of Guiyang city, South China. Different methods are used to find out the problem of system and the reason for delay. Moreover, optimization suggestion is proposed according to result. Compared with other methods, the two-factor method has the advantage of locating the reason of delay for each station. The time performance is not superior to other methods. By comparing the situation of adjacent station, the proportion of traffic congestion and overload passenger in bus delay was determined. The two-factor method is applicable for other transit system in different cities which has similar structure as Guiyang. However, for cities with other structure, a feasibility should be made to select an appropriate model.

  • 1167039.
    Zhang, Li
    et al.
    Dalian Univ Technol, DUT KTH Joint Educ & Res Ctr Mol Devices, Inst Artificial Photosynth, State Key Lab Fine Chem, 2 Linggong Rd, Dalian 116024, Peoples R China..
    Yang, Xichuan
    Dalian Univ Technol, DUT KTH Joint Educ & Res Ctr Mol Devices, Inst Artificial Photosynth, State Key Lab Fine Chem, 2 Linggong Rd, Dalian 116024, Peoples R China..
    Wang, Weihan
    Dalian Univ Technol, DUT KTH Joint Educ & Res Ctr Mol Devices, Inst Artificial Photosynth, State Key Lab Fine Chem, 2 Linggong Rd, Dalian 116024, Peoples R China..
    Gurzadyan, Gagik G.
    Dalian Univ Technol, DUT KTH Joint Educ & Res Ctr Mol Devices, Inst Artificial Photosynth, State Key Lab Fine Chem, 2 Linggong Rd, Dalian 116024, Peoples R China..
    Li, Jiajia
    Dalian Univ Technol, DUT KTH Joint Educ & Res Ctr Mol Devices, Inst Artificial Photosynth, State Key Lab Fine Chem, 2 Linggong Rd, Dalian 116024, Peoples R China..
    Li, Xiaoxin
    Dalian Univ Technol, DUT KTH Joint Educ & Res Ctr Mol Devices, Inst Artificial Photosynth, State Key Lab Fine Chem, 2 Linggong Rd, Dalian 116024, Peoples R China..
    An, Jincheng
    Dalian Univ Technol, DUT KTH Joint Educ & Res Ctr Mol Devices, Inst Artificial Photosynth, State Key Lab Fine Chem, 2 Linggong Rd, Dalian 116024, Peoples R China..
    Yu, Ze
    Dalian Univ Technol, DUT KTH Joint Educ & Res Ctr Mol Devices, Inst Artificial Photosynth, State Key Lab Fine Chem, 2 Linggong Rd, Dalian 116024, Peoples R China..
    Wang, Haoxin
    Dalian Univ Technol, DUT KTH Joint Educ & Res Ctr Mol Devices, Inst Artificial Photosynth, State Key Lab Fine Chem, 2 Linggong Rd, Dalian 116024, Peoples R China..
    Cai, Bin
    Dalian Univ Technol, DUT KTH Joint Educ & Res Ctr Mol Devices, Inst Artificial Photosynth, State Key Lab Fine Chem, 2 Linggong Rd, Dalian 116024, Peoples R China..
    Hagfeldt, Anders
    Ecole Polytech Fed Lausanne, Lab Photomol Sci, Inst Chem Sci & Engn, CH-1015 Lausanne, Switzerland..
    Sun, Licheng
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Chemistry, Organic chemistry. Dalian Univ Technol, DUT KTH Joint Educ & Res Ctr Mol Devices, Inst Artificial Photosynth, State Key Lab Fine Chem, 2 Linggong Rd, Dalian 116024, Peoples R China.
    13.6% Efficient Organic Dye-Sensitized Solar Cells by Minimizing Energy Losses of the Excited State2019In: ACS ENERGY LETTERS, ISSN 2380-8195, Vol. 4, no 4, p. 943-951Article in journal (Refereed)
    Abstract [en]

    The electron-injection energy losses of dye-sensitized solar cells (DSSCs) are among the fundamental problems hindering their successful breakthrough application. Two triazatruxene (TAT)-based sensitizers, with one containing a flexible Z-type double bond and another a rigid single bond, coded as ZL001 and ZL003, respectively, have been synthesized and applied in DSSCs to probe the energy losses in the process of electron injection. Using time-resolved laser spectroscopic techniques in the kinetic study, ZL003 with the rigid single bond promotes much faster electron injection into the conductive band of TiO2 especially in the locally excited state (hot injection), which leads to higher electron density in TiO2 and a higher V-oc. The devices based on ZL003 exhibited a champion power conversion efficiency (PCE) of 13.6% with V-oc = 956 mV, J(sc) = 20.73 mA cm(-2), and FF = 68.5%, which are among the highest recorded results to date on single dye-sensitized DSSCs. An independent certified PCE of 12.4% has been obtained for devices based on ZL003.

  • 1167040.
    Zhang, Liang
    Linköping University, Department of Electrical Engineering, Automatic Control.
    Network Capacity, Coverage Estimation and Frequency Planning of 3GPP Long Term Evolution2010Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    The recent increase of mobile data usage and emergence of new applications such as Online Gaming, mobile TV, Web 2.0, Streaming Contents have greatly motivated the 3rd Generation Partnership Project (3GPP) to work on the Long Term Evolution (LTE). The LTE is the latest standard in the mobile network technology tree. It inherits and develops the GSM/EDGE and UMTS/HSPA network technologies and is a step toward the 4th generation (4G) of radio technologies designed to optimize the capacity and speed of 3G mobile communication networks. In this thesis, the LTE system capacity and coverage are investigated and a model is proposed on the base of the Release 8 of 3GPP LTE standards. After that, the frequency planning of LTE is also studied. The results cover the interference limited coverage calculation, the traffic capacity calculation and radio frequency assignment. The implementation is achieved on the WRAP software platform for the LTE Radio Planning.

  • 1167041.
    Zhang, Liang
    et al.
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Industrial Biotechnology. VINNOVA Competence Ctr Adv Bioprod Continuous Pro, AdBIOPRO, Stockholm, Sweden..
    Castan, Andreas
    GE Healthcare Biosci AB, Bjorkgatan 30, S-75184 Uppsala, Sweden..
    Stevenson, Joanne
    Cobra Biol AB, Stockholm, Sweden..
    Chatzissavidou, Nathalie
    Cobra Biol AB, Stockholm, Sweden..
    Vilaplana, Francisco
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Chemistry, Glycoscience.
    Chotteau, Veronique
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Industrial Biotechnology. VINNOVA Competence Ctr Adv Bioprod Continuous Pro, AdBIOPRO, Stockholm, Sweden..
    Combined effects of glycosylation precursors and lactate on the glycoprofile of IgG produced by CHO cells2019In: Journal of Biotechnology, ISSN 0168-1656, E-ISSN 1873-4863, Vol. 289, p. 71-79Article in journal (Refereed)
    Abstract [en]

    The glycosylation profile of therapeutic monoclonal antibodies (mAbs) is a crucial quality parameter for industrial Immunoglobulin G (IgG) production. Several alternative carbon sources, which function as glycosylation precursors, have been reported to impact the glycosylation pattern. Since the cells give priority to glucose uptake, the presence of this substrate can lower the effects of alternative sugars on the glycosylation. In order to get a better understanding of the influence of alternative sugars on the glycosylation and to investigate how they impact each other, combinations of mannose, fructose, galactose and fucose were fed to Chinese hamster ovary (CHO) cells in batch culture when the glucose became depleted and the lactate, accumulated in the culture, was used as carbon source. Feeding with a feed containing mannose or glucose decreased by 3-7% the percentage of high mannose glycans compared to a feed without mannose or glucose. Feeding with a feed containing galactose led to 8-20% increase of monogalactoglycans (G1) glycans and 2-6% rise of digalactoglycans (G2) glycans compared to feeding without galactose or glucose. The cells fed with fucose exhibited a significantly higher concentration of intracellular GDP-Fucose. This work indicates that a feeding strategy based on non-glucose sugars and potentially lactate, could be adopted to obtain a targeted glycosylation profile.

  • 1167042. Zhang, Liang
    et al.
    Fontana, Jacopo
    Bernhem, Kristoffer
    Nilsson, Linnéa
    KTH, School of Engineering Sciences (SCI), Applied Physics, Biophysics.
    Scott, Lena
    Blom, Hans
    KTH, School of Engineering Sciences (SCI), Applied Physics, Biophysics.
    Brismar, Hjalmar
    KTH, School of Engineering Sciences (SCI), Applied Physics, Biophysics.
    Aperia, Anita
    Ouabain intervenes early in the apoptotic process by preventing BAD activationManuscript (preprint) (Other academic)
  • 1167043.
    Zhang, Liang
    et al.
    Pennsylvania State University, USA.
    Khan, Gulab
    Aga Khan Education Service, Pakistan.
    Tahirsylaj, Armend
    Pennsylvania State University, USA.
    Student Performance, School Differentiation, and World Cultures: Evidence from PISA 20092015In: International Journal of Educational Development, ISSN 0738-0593, E-ISSN 1873-4871, Vol. 42, no May, p. 43-53Article in journal (Refereed)
    Abstract [en]

    PISA 2009 data were used to identify patterns of differences and similarities among PISA participating countries/economies. The concept of cultural clusters was used to show patterns of differences and similarities within and across country clusters in two indicators – average student performance and school differentiations (measured by proportion of variance in student test scores explained by schools). Results revealed striking similarities among countries within many cultural clusters, while significant dispersion was found in others, especially among Eastern Europe countries. Regression analyses indicated that cultural clusters explain the majority of variance in average student performance and school differentiations across countries, suggesting that culture is an important factor when comparing and contrasting different school systems.

  • 1167044. Zhang, Liang
    et al.
    Vinogradov, Nikolay
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Molecular and condensed matter physics.
    Preobrajenski, Alexei
    Butorin, Sergei
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Molecular and condensed matter physics.
    Zhu, Junfa
    Guo, Jinghua
    Probing substrate-induced perturbations on the band structure of graphene on Ni(111) by soft X-ray emission spectroscopy2013In: Chemical Physics Letters, ISSN 0009-2614, E-ISSN 1873-4448, Vol. 580, p. 43-47Article in journal (Refereed)
    Abstract [en]

    The influence of substrate-induced perturbations on the band structure of graphene has been investigated by soft X-ray emission spectroscopy (XES) for graphene on Ni(111). The band-dispersion features of graphene on Ni(111) are different from those of HOPG and 'quasi-freestanding' graphene (graphene/Cu) because of the strong interfacial interaction. By comparing the XES spectra excited with energy at the pi* resonance of HOPG, graphene/Cu and graphene/Ni in detail, we find that the spectral shape change can be directly related to the different electronic states hybridization strength of graphene on metal substrates, supplying a feasible way for investigating the graphene-metal bonding strength. 

  • 1167045. Zhang, Liang
    et al.
    Wang, Wujun
    KTH, School of Industrial Engineering and Management (ITM), Energy Technology.
    Yu, Zitao
    Fan, Liwu
    Hu, Yacai
    Ni, Yu
    Fan, Jianren
    Cen, Kefa
    An experimental investigation of a natural circulation heat pipe system applied to a parabolic trough solar collector steam generation system2012In: Solar Energy, ISSN 0038-092X, E-ISSN 1471-1257, Vol. 86, no 3, p. 911-919Article in journal (Refereed)
    Abstract [en]

    A U-type natural circulation heat pipe system is designed and applied to a parabolic trough solar collector for generating mid-temperature steam. Thermal performance of the heat pipe system is investigated experimentally. A detailed heat transfer analysis is performed on thermal behaviors of the system, especially the solar collector. The results show that the system can generate mid-temperature steam of a pressure up to 0.75 MPa. The thermal efficiency is found to be 38.52% at discharging pressure of 0.5 MPa during summer time.

  • 1167046. Zhang, Liang
    et al.
    Yu, Zitao
    Fan, Liwu
    Wang, Wujun
    KTH, School of Industrial Engineering and Management (ITM), Energy Technology, Heat and Power Technology.
    Chen, Huan
    Hu, Yacai
    Fan, Jianren
    Ni, Mingjiang
    Cen, Kefa
    An experimental investigation of the heat losses of a U-type solar heat pipe receiver of a parabolic trough collector-based natural circulation steam generation system2013In: Renewable energy, ISSN 0960-1481, E-ISSN 1879-0682, Vol. 57, p. 262-268Article in journal (Refereed)
    Abstract [en]

    The performance of a parabolic trough collector (PTC)-based steam generation system depends significantly on the heat losses of the solar receiver. This paper presents an experimental study of the heat losses of a double glazing vacuum U-type solar receiver mounted in a PTC natural circulation system for generating medium-temperature steam. Field experiments were performed to determine the overall heat losses of the receiver. Effects of wind, vacuum glass tube, radiation, and structural characteristics on the heat losses were analyzed. The thermal efficiency of the receiver was found to be 0.791 and 0.472 in calm and windy days, respectively, at a test temperature of about 100 degrees C, whereas the thermal efficiencies became 0.792 and 0.663, respectively, while taking the receiver element into consideration. The heat losses were increased from 0.183 to 0.255 kW per receiver for the two cases tested. It was shown that neither convection nor radiation heat losses may be negligible in the analysis of such U-type solar receivers.

  • 1167047.
    Zhang, Liangdong
    et al.
    Nanjing Tech Univ, Peoples R China.
    Jiang, Tao
    Nanjing Tech Univ, Peoples R China.
    Yi, Chang
    Nanjing Tech Univ, Peoples R China.
    Wu, Jiquan
    Linköping University, Department of Physics, Chemistry and Biology, Surface Physics and Chemistry. Linköping University, Faculty of Science & Engineering.
    Liu, Xiaoke
    Linköping University, Department of Physics, Chemistry and Biology, Biomolecular and Organic Electronics. Linköping University, Faculty of Science & Engineering.
    He, Yaron
    Nanjing Tech Univ, Peoples R China.
    Miao, Yanfeng
    Nanjing Tech Univ, Peoples R China.
    Zhang, Ya
    Nanjing Tech Univ, Peoples R China.
    Zhang, Huotian
    Linköping University, Department of Physics, Chemistry and Biology, Biomolecular and Organic Electronics. Linköping University, Faculty of Science & Engineering.
    Xie, Xinrui
    Zhejiang Univ, Peoples R China.
    Wang, Peng
    Zhejiang Univ, Peoples R China.
    Li, Renzhi
    Nanjing Tech Univ, Peoples R China; Nanjing Tech Univ, Peoples R China.
    Gao, Feng
    Linköping University, Department of Physics, Chemistry and Biology, Biomolecular and Organic Electronics. Linköping University, Faculty of Science & Engineering.
    Huang, Wei
    Nanjing Tech Univ, Peoples R China; Nanjing Tech Univ, Peoples R China; NPU, Peoples R China.
    Wang, Jianpu
    Nanjing Tech Univ, Peoples R China.
    Bright Free Exciton Electroluminescence from Mn-Doped Two-Dimensional Layered Perovskites2019In: Journal of Physical Chemistry Letters, ISSN 1948-7185, E-ISSN 1948-7185, Vol. 10, no 11, p. 3171-3175Article in journal (Refereed)
    Abstract [en]

    Two-dimensional (2D) perovskites incorporating hydrophobic organic spacer cations show improved film stability and morphology compared to their three-dimensional (3D) counterparts. However, 2D perovskites usually exhibit low photoluminescence quantum efficiency (PLQE) owing to strong exciton-phonon interaction at room temperature, which limits their efficiency in light-emitting diodes (LEDs). Here, we demonstrate that the device performance of 2D perovskite LEDs can be significantly enhanced by doping Mn(2+)in (benzimidazolium)(2)PbI4 2D perovskite films to suppress the exciton-phonon interaction. The distorted [PbI6](4-) octahedra by Mn-doping and the rigid benzimidazolium (BIZ) ring without branched chains in the 2D perovskite structure lead to improved crystallinity and rigidity of the perovskites, resulting in suppressed phonon-exciton interaction and enhanced PLQE. On the basis of this strategy, for the first time, we report yellow electroluminescence from free excitons in 2D (n = 1) perovskites with a maximum brightness of 225 cd m(-2) and a peak EQE of 0.045%.

  • 1167048.
    Zhang, Liangwei
    Luleå University of Technology, Department of Civil, Environmental and Natural Resources Engineering, Operation, Maintenance and Acoustics.
    An Approach of Big Data Analytics for Fault Detection2014In: Newsletter of European Safety and Reliability Association, p. 3-5Article in journal (Other (popular science, discussion, etc.))
  • 1167049.
    Zhang, Liangwei
    Luleå University of Technology, Department of Civil, Environmental and Natural Resources Engineering, Operation, Maintenance and Acoustics.
    Big Data Analytics for eMaintenance: Modeling of high-dimensional data streams2015Licentiate thesis, comprehensive summary (Other academic)
    Abstract [en]

    Big Data analytics has attracted intense interest from both academia and industry recently for its attempt to extract information, knowledge and wisdom from Big Data. In industry, with the development of sensor technology and Information & Communication Technologies (ICT), reams of high-dimensional data streams are being collected and curated by enterprises to support their decision-making. Fault detection from these data is one of the important applications in eMaintenance solutions with the aim of supporting maintenance decision-making. Early discovery of system faults may ensure the reliability and safety of industrial systems and reduce the risk of unplanned breakdowns. Both high dimensionality and the properties of data streams impose stringent challenges on fault detection applications. From the data modeling point of view, high dimensionality may cause the notorious “curse of dimensionality” and lead to the accuracy deterioration of fault detection algorithms. On the other hand, fast-flowing data streams require fault detection algorithms to have low computing complexity and give real-time or near real-time responses upon the arrival of new samples. Most existing fault detection models work on relatively low-dimensional spaces. Theoretical studies on high-dimensional fault detection mainly focus on detecting anomalies on subspace projections of the original space. However, these models are either arbitrary in selecting subspaces or computationally intensive. In considering the requirements of fast-flowing data streams, several strategies have been proposed to adapt existing fault detection models to online mode for them to be applicable in stream data mining. Nevertheless, few studies have simultaneously tackled the challenges associated with high dimensionality and data streams. In this research, an Angle-based Subspace Anomaly Detection (ABSAD) approach to fault detection from high-dimensional data is developed. Both analytical study and numerical illustration demonstrated the efficacy of the proposed ABSAD approach. Based on the sliding window strategy, the approach is further extended to an online mode with the aim of detecting faults from high-dimensional data streams. Experiments on synthetic datasets proved that the online ABSAD algorithm can be adaptive to the time-varying behavior of the monitored system, and hence applicable to dynamic fault detection.

  • 1167050.
    Zhang, Liangwei
    Luleå University of Technology, Department of Civil, Environmental and Natural Resources Engineering, Operation, Maintenance and Acoustics.
    Big Data Analytics for Fault Detection and its Application in Maintenance2016Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Big Data analytics has attracted intense interest recently for its attempt to extract information, knowledge and wisdom from Big Data. In industry, with the development of sensor technology and Information & Communication Technologies (ICT), reams of high-dimensional, streaming, and nonlinear data are being collected and curated to support decision-making. The detection of faults in these data is an important application in eMaintenance solutions, as it can facilitate maintenance decision-making. Early discovery of system faults may ensure the reliability and safety of industrial systems and reduce the risk of unplanned breakdowns.

    Complexities in the data, including high dimensionality, fast-flowing data streams, and high nonlinearity, impose stringent challenges on fault detection applications. From the data modelling perspective, high dimensionality may cause the notorious “curse of dimensionality” and lead to deterioration in the accuracy of fault detection algorithms. Fast-flowing data streams require algorithms to give real-time or near real-time responses upon the arrival of new samples. High nonlinearity requires fault detection approaches to have sufficiently expressive power and to avoid overfitting or underfitting problems.

    Most existing fault detection approaches work in relatively low-dimensional spaces. Theoretical studies on high-dimensional fault detection mainly focus on detecting anomalies on subspace projections. However, these models are either arbitrary in selecting subspaces or computationally intensive. To meet the requirements of fast-flowing data streams, several strategies have been proposed to adapt existing models to an online mode to make them applicable in stream data mining. But few studies have simultaneously tackled the challenges associated with high dimensionality and data streams. Existing nonlinear fault detection approaches cannot provide satisfactory performance in terms of smoothness, effectiveness, robustness and interpretability. New approaches are needed to address this issue.

    This research develops an Angle-based Subspace Anomaly Detection (ABSAD) approach to fault detection in high-dimensional data. The efficacy of the approach is demonstrated in analytical studies and numerical illustrations. Based on the sliding window strategy, the approach is extended to an online mode to detect faults in high-dimensional data streams. Experiments on synthetic datasets show the online extension can adapt to the time-varying behaviour of the monitored system and, hence, is applicable to dynamic fault detection. To deal with highly nonlinear data, the research proposes an Adaptive Kernel Density-based (Adaptive-KD) anomaly detection approach. Numerical illustrations show the approach’s superiority in terms of smoothness, effectiveness and robustness.

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