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  • 1. Amon, M
    et al.
    Keramidas, Michail E.
    Kounalakis, S
    Kölegård, Roger
    KTH, School of Technology and Health (STH), Environmental Physiology (Closed 20130701).
    Simpson, L
    MacDonald, I
    Eiken, Ola
    KTH, School of Technology and Health (STH), Environmental Physiology (Closed 20130701).
    Mekjavic, IB
    Effect of hypoxia on postprandial blood glucose and insulin response2011Conference paper (Refereed)
  • 2. Bali, TC
    et al.
    Kounalakis, SN
    Eiken, Ola
    KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Environmental Physiology. KTH, School of Technology and Health (STH), Centres, Swedish Aerospace Physiology Centre, SAPC.
    Mekjavic, IB
    PlanHab: The effects of 21-day hypoxic confinement and unloading/inactivity on regional body composition and muscle strength2015Conference paper (Refereed)
  • 3. Ciuha, U
    et al.
    Eiken, Ola
    KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Environmental Physiology. KTH, School of Technology and Health (STH), Centres, Swedish Aerospace Physiology Centre, SAPC.
    Mekjavic, IB
    PlanHab: Effects of normobaric hypoxic bed rest on behavioural temperature regulation2015Conference paper (Refereed)
  • 4. Ciuha, U
    et al.
    Grönkvist, Mikael
    KTH, School of Technology and Health (STH), Environmental Physiology.
    Mekjavic, I
    Kölegård, Roger
    KTH, School of Technology and Health (STH), Environmental Physiology.
    Pavlinič, D
    Eiken, Ola
    KTH, School of Technology and Health (STH), Environmental Physiology.
    Thermal strain in soldiers performing patrol missions in a desert climate: effect of two different cooling strategies2011Conference paper (Refereed)
  • 5. Debevec, T
    et al.
    Ehrström, S
    Pialoux, V
    Eiken, Ola
    KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Environmental Physiology. KTH, School of Technology and Health (STH), Centres, Swedish Aerospace Physiology Centre, SAPC.
    Mekjavic, IB
    Millet, GP
    FemHab: Prooxidant/antioxidant balance during and following a 10-day hypoxic bed rest2015Conference paper (Refereed)
    Abstract [en]

    Introduction:Inhabitants of the envisaged planetary habitats will be continuously exposed to reduced gravity and hypoxia. The combined effects of unloading and hypoxia on prooxidant/antioxidant balance are currently unknown.

    Methods:Healthy female participants underwent the following three, 10-day interventions: i) Normobaric normoxic bed-rest (NBR; n=11; FiO2=0.209) ii) Normobaric hypoxic ambulatory confinement (HAMB; n=9: FiO2~0.141), and iii) Normobaric hypoxic bed-rest (HBR; n=12; FiO2~0.141). Plasma oxidative stress [advanced oxidation protein products (AOPP) and nitrotyrosine], antioxidant markers [superoxide dismutase (SOD) and glutathione peroxidase (GPX)] and nitrites were determined before (Pre), during (Day 2, Day 6), immediately after (Post) and 24-hrs after (Post+1) each campaign.

    Results:Compared to Pre, the AOPP was only higher on Day 2, Day 6 and Post during the HBR and at Post during the NBR (P<0.05) while the nitrotyrosine was significantly reduced at Post+1 only during the HAMB (P<0.05). Higher levels of SOD were observed during the HAMB at Day 6 and Post+1whereas GPX was reduced at Day 6 and Post during the HBR. Nitrites were significantly higher at Post+1 in the HAMB both, compared to Pre and compared to HBR and NBR (P<0.05).

    Conclusion:These data suggest that the unloading-induced oxidative stress is exacerbated by exposure to simulated altitude of ~4000m. In addition, even habitual (low) physical activity, performed during hypoxic exposure, seems to blunt hypoxia-related oxidative stress via antioxidant system upregulation.

  • 6. Debevec, T
    et al.
    Simpson, EJ
    Eiken, Ola
    KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Environmental Physiology. KTH, School of Technology and Health (STH), Centres, Swedish Aerospace Physiology Centre, SAPC.
    Mekjavic, IB
    Macdonald, IA
    PlanHab: The individual and combined effects of inactivity and hypoxia on insulin resistance2015Conference paper (Refereed)
    Abstract [en]

    Inactivity is know to aggravate insulin resistance. The effects of hypoxia on insulin and glucose metabolism, on the other hand, are not completely understood.

  • 7. Dolenc Grošelj, L
    et al.
    Morrisson, SA
    Mirnik, D
    Korsic, S
    Eiken, Ola
    KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Environmental Physiology. KTH, School of Technology and Health (STH), Centres, Swedish Aerospace Physiology Centre, SAPC.
    Mekjavic, IB
    PlanHab: Periodic breathing during hypoxic bedrest2015Conference paper (Refereed)
  • 8.
    Eiken, Ola
    et al.
    KTH, School of Technology and Health (STH), Environmental Physiology.
    Danielsson, Ulf
    Hallberg, M
    Mekjavic, IB
    Babic, J
    Kounalakis, S
    Energy expenditure during simulated patrol in darkness2011Conference paper (Refereed)
  • 9.
    Eiken, Ola
    et al.
    KTH, School of Technology and Health (STH), Environmental Physiology.
    Mekjavic, IB
    Kounalakis, S
    Kölegård, Roger
    KTH, School of Technology and Health (STH), Environmental Physiology.
    Stiffness in leg arteries/arterioles is reduced by prolonged bedrest.2011Conference paper (Refereed)
  • 10.
    Gennser, Mikael
    et al.
    KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Environmental Physiology. KTH, School of Technology and Health (STH), Centres, Swedish Aerospace Physiology Centre, SAPC.
    Blogg, L
    Eiken, Ola
    KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Environmental Physiology. KTH, School of Technology and Health (STH), Centres, Swedish Aerospace Physiology Centre, SAPC.
    Jaki Mekjavic, P
    Mekjavic, IB
    Comparison of venous bubbles and tear film bubbles after decompression during a five week 6° head-down tilt bed rest2015Conference paper (Refereed)
  • 11.
    Gennser, Mikael
    et al.
    KTH, School of Technology and Health (STH), Environmental Physiology.
    Blogg, L.
    Eiken, Ola
    KTH, School of Technology and Health (STH), Environmental Physiology.
    Mekjavic, I.
    Comparison between mild dehydration and body temperature on decompression bubble formation2010Conference paper (Refereed)
  • 12.
    Grönkvist, Mikael
    et al.
    KTH, School of Technology and Health (STH), Environmental Physiology.
    Bergsten, Eddie
    KTH, School of Technology and Health (STH), Environmental Physiology.
    Eiken, Ola
    KTH, School of Technology and Health (STH), Environmental Physiology.
    Loss of pressure in the anti-G system at high G-loads2011Conference paper (Refereed)
  • 13.
    Grönkvist, Mikael
    et al.
    KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Environmental Physiology. KTH, School of Technology and Health (STH), Centres, Swedish Aerospace Physiology Centre, SAPC.
    Ciuha, U
    Mekjavic, IB
    Eiken, Ola
    KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Environmental Physiology. KTH, School of Technology and Health (STH), Centres, Swedish Aerospace Physiology Centre, SAPC.
    Värmebelastning i helikopter vid simulerat ökenuppdrag2015Conference paper (Refereed)
  • 14.
    Grönkvist, Mikael
    et al.
    KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Environmental Physiology. KTH, School of Technology and Health (STH), Centres, Swedish Aerospace Physiology Centre, SAPC.
    Keramidas, Michail
    KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Environmental Physiology. KTH, School of Technology and Health (STH), Centres, Swedish Aerospace Physiology Centre, SAPC.
    Eiken, Ola
    KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Environmental Physiology. KTH, School of Technology and Health (STH), Centres, Swedish Aerospace Physiology Centre, SAPC.
    Samverkan mellan anti-G-dräkt och övertryck i luftvägarna på cerebral syresättning vid långvarig G-belastning i huvud-fot riktning2015Conference paper (Refereed)
  • 15. Helena, C. H.
    et al.
    Jelena, V. M.
    Nataša, R.
    Vito, F.
    Mekjavic, I. B.
    Eiken, Ola
    KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Environmental Physiology.
    Robert, Z.
    A new approach to study properties of isolated preadipocytes following in vivo exposure to hypoxia2013In: Proceedings of Life in space for life on earth, 18-22 June 2012, Aberdeen, ESA Communications , 2013Conference paper (Refereed)
    Abstract [en]

    In the present study we developed a novel approach to study the properties of isolated human preadipocytes from subjects exposed to conditions of hypoxia equivalent to an altitude of 4000 m. By using confocal microscopy we studied the expression of dipeptidyl peptidase 4 (DPP4) in preadipocytes from adult normal-weight males. DPP4 is a transmembrane glycoprotein with enzymatic activity that cleaves Nterminal dipeptides from a diverse range of substrates. The activity of DPP4 is implicated in immune response as well as in glucose homeostasis. To gain insights into the pathophysiological role of DPP4 in insulin resistance we here explored DPP4 expression during prolonged exposure to hypoxia, an experimental model of obesity onset. We used here a rapid method to isolate cells from biopsies and immunolabelled them with antibodies. Then cells were prepared for the analysis with confocal microscopy. The results show that a prolonged exposure to hypoxic environment appears to increases the expression of DPP4 on preadipocytes.

  • 16. Jaki Mekjavic, P
    et al.
    Lenassi, E
    Eiken, Ola
    KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Environmental Physiology. KTH, School of Technology and Health (STH), Centres, Swedish Aerospace Physiology Centre, SAPC.
    Mekjavic, IB
    FemHab: The effect of acute hypercapnia during hypoxic bedrest on posterior eye structures in females2015Conference paper (Refereed)
  • 17. Keramidas, Michail E.
    et al.
    Kounalakis, S.
    Debevec, T.
    Norman, B.
    Gustafsson, T.
    Eiken, Ola
    KTH, School of Technology and Health (STH), Environmental Physiology (Closed 20130701).
    Mekjavic, I.
    The effect of acute normobaric hyperoxia on EPO concentration in healthy males2010Conference paper (Refereed)
  • 18. Keramidas, Michail E.
    et al.
    Norman, B.
    Gustafsson, T.
    Eiken, Ola
    KTH, School of Technology and Health (STH), Environmental Physiology (Closed 20130701).
    Mekjavic, I.B.
    Enhancement of erythropoiesis with normobaric hyperoxia: a promising treatment turns “anaemic”?2011Conference paper (Refereed)
  • 19.
    Kölegård, Roger
    et al.
    KTH, School of Technology and Health (STH), Environmental Physiology.
    Eiken, Ola
    KTH, School of Technology and Health (STH), Environmental Physiology.
    Betydelse av in vivo styvhet hos perifera blodkärl ur ett flygmedicinskt perspektiv2011Conference paper (Refereed)
  • 20.
    Kölegård, Roger
    et al.
    KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Environmental Physiology.
    Sundblad, Patrik
    KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Environmental Physiology.
    Grönkvist, Mikael
    KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Environmental Physiology.
    Eiken, Ola
    KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Environmental Physiology.
    Är det möjligt att uppskatta Gz-tolerans medelst ortostatisk prov?2015Conference paper (Refereed)
  • 21. MacDonnell, A.
    et al.
    Pavlinič, D.
    Ciuha, U.
    Kölegård, Roger
    KTH, School of Technology and Health (STH), Environmental Physiology.
    Eiken, Ola
    KTH, School of Technology and Health (STH), Environmental Physiology.
    Mekjavic, I.
    The correlation between the cold-induced vasodilatation response and toe skin temperature during winter hikes in the alps2011Conference paper (Refereed)
  • 22. McDonnell, A. C.
    et al.
    Mekjavic, I. B.
    Dolenc-Grošelj, L.
    Mekjavic, P. J.
    Eiken, Ola
    KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Environmental Physiology.
    Effect of hypoxia and bedrest on peripheral vasoconstriction2013In: Proceedings of Life in space for life on earth, 18-22 June 2012, Aberdeen, ESA Communications , 2013, 1-2 p.Conference paper (Refereed)
    Abstract [en]

    Future planetary habitats may expose astronauts to both microgravity and hypobaric hypoxia, both inducing a reduction in peripheral perfusion. Peripheral temperature changes have been linked to sleep onset and quality [5]. However, it is still unknown what effect combining hypoxia and bedrest has on this relationship. Eleven male participants underwent three 10-day campaigns in a randomized manner: 1) normobaric hypoxic ambulatory confinement (HAmb); 2) normobaric hypoxic bed rest (HBR); 3) normobaric normoxic bed rest (NBR). There was no change in skin temperature gradient between the calf and toes, an index of peripheral perfusion (ΔTc-t), over the 10-d period in the HAmb trial. However, there was a significant increase (p< 0.001) in daytime (9am-9pm) ΔTc-t on day 10 of the inactivity/unloading periods (HBR and NBR trials). This reduction in the perfusion of the toes during the daytime was augmented during the HBR trial compared to NBR (p< 0.001). Before and on day 10 of the interventions we conducted polysomnographic assessment, which revealed no changes in sleep onset and/or architecture. These data support the theory that circadian changes in temperature are functionally linked to sleepiness [1].

  • 23. McDonnell, A
    et al.
    Stavrou, N
    Eiken, Ola
    KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Environmental Physiology. KTH, School of Technology and Health (STH), Centres, Swedish Aerospace Physiology Centre, SAPC.
    Mekjavic, IB
    PlanHab: The effect of activity during hypoxic confinement on emotional state2015Conference paper (Refereed)
  • 24. McDonnell, AC
    et al.
    Eiken, Ola
    KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Environmental Physiology. KTH, School of Technology and Health (STH), Centres, Swedish Aerospace Physiology Centre, SAPC.
    Mekjavic, IB
    Peripheral Perfusion and Acute Mountain Sickness: Is There a Link?2015Conference paper (Refereed)
  • 25. McDonnell, AC
    et al.
    Stavrou, N
    Eiken, Ola
    KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Environmental Physiology. KTH, School of Technology and Health (STH), Centres, Swedish Aerospace Physiology Centre, SAPC.
    Mekjavic, IB
    The Effect of a Live-High/Train-High Regimen on Emotional State2015Conference paper (Refereed)
  • 26. Mekjavic, I.
    et al.
    Eiken, Ola
    KTH, School of Technology and Health (STH), Environmental Physiology.
    Blogg, L.
    Jaki Mekjavic, P.
    Gennser, Mikael
    KTH, School of Technology and Health (STH), Environmental Physiology.
    Mild dehydration per se does not increase the risk of decompression sickness2010Conference paper (Refereed)
  • 27. Mekjavic, IB
    et al.
    Bali, T
    McDonnell, AC
    Debevec, T
    Simpson, EJ
    MacDonald, IA
    Eiken, Ola
    KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Environmental Physiology. KTH, School of Technology and Health (STH), Centres, Swedish Aerospace Physiology Centre, SAPC.
    FemHab: Effects of 10-day planetary habitation simulation on body composition and resting energy expenditure in females2015Conference paper (Refereed)
  • 28. Mekjavic, I.B.
    et al.
    Keramidas, Michail E.
    Amon, M.
    Debevec, T.
    Eiken, Ola
    KTH, School of Technology and Health (STH), Environmental Physiology (Closed 20130701).
    Jaki-Mekjavic, P.
    Kounalakis, S.N.
    Evaluation of hypoxic training regimens2011Conference paper (Refereed)
  • 29. Mekjavic, IB
    et al.
    MacDonald, IA
    Chouker, A
    Rittweger, J
    Grassi, B
    Aliverti, A
    Biolo, G
    Eiken, Ola
    KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Environmental Physiology. KTH, School of Technology and Health (STH), Centres, Swedish Aerospace Physiology Centre, SAPC.
    The Planetary Habitat project2015Conference paper (Refereed)
  • 30.
    Nobel, Gerard
    et al.
    KTH, School of Technology and Health (STH), Environmental Physiology.
    Tribukait, Arne
    KTH, School of Technology and Health (STH), Environmental Physiology.
    Mekjavic, I.B.
    Eiken, Ola
    KTH, School of Technology and Health (STH), Environmental Physiology.
    Effects of motion sickness on thermoregulatory responses in a thermoneutral air environment2011Conference paper (Refereed)
  • 31. Petrič, M
    et al.
    Jakovljević, M
    Eiken, Ola
    KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Environmental Physiology. KTH, School of Technology and Health (STH), Centres, Swedish Aerospace Physiology Centre, SAPC.
    Mekjavic, IB
    FemHab: Effect of 10-day hypoxic bed rest on static balance in females2015Conference paper (Refereed)
  • 32. Potrc, M
    et al.
    Šuštar, M
    Jaki Mekjavic, P
    Hawlina, M
    Eiken, Ola
    KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Environmental Physiology. KTH, School of Technology and Health (STH), Centres, Swedish Aerospace Physiology Centre, SAPC.
    Mekjavic, IB
    FemHab: The effect of sustained bedrest and hypoxia on electroretinographic responses2015Conference paper (Refereed)
  • 33. Salvadego, D.
    et al.
    Keramidas, Michail E.
    Eiken, Ola
    KTH, School of Technology and Health (STH), Environmental Physiology (Closed 20130701).
    Mekjavic, I.B.
    Grassi, B.
    Effects of hypoxia and microgravity on skeletal muscle oxidative metabolism2011In: Italian Society of Space Biomedicine and Biotechnology (ISSBB), 2011Conference paper (Refereed)
  • 34. Stavrou, N. A.
    et al.
    McDonnell, A. C.
    Eiken, Ola
    KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Environmental Physiology.
    Mekjavic, I. B.
    Indices of psychological strain during hypoxic bedrest and confinement2013In: Proceedings of Life in space for life on earth, 18-22 June 2012, Aberdeen, European Space Agency , 2013Conference paper (Refereed)
    Abstract [en]

    Much attention has been devoted to the physiological changes that occur during bed rest. However, there has been a lack of focus on the psychological aspects per se. We investigated indices of psychological strain during three 10-d interventions, designed to assess the combined effects of inactivity/unloading and normobaric hypoxia on several physiological systems. Eleven male participants underwent three 10-d campaigns in a randomized manner: 1) normobaric hypoxic ambulatory confinement (HAMB), 2) normobaric hypoxic bed rest (HBR) and 3) normoxic bed rest (NBR). The most negative psychological profile appeared on BR10 of HBR and HAmb conditions (hypoxic conditions). Concomitantly a decrease in positive emotions was observed from BR-2 to BR10. Bed rest and exposure to hypoxic environments seems to exert a negative effect on person's psychological mood.

  • 35. Stavrou, NAM
    et al.
    Debevec, T
    Eiken, Ola
    KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Environmental Physiology. KTH, School of Technology and Health (STH), Centres, Swedish Aerospace Physiology Centre, SAPC.
    Mekjavic, IB
    PlanHab: Examining the effect of 21-day hypoxic bed rest and confinement on emotional state2015Conference paper (Refereed)
  • 36.
    Tribukait, Arne
    et al.
    KTH, School of Technology and Health (STH), Environmental Physiology.
    Eiken, Ola
    KTH, School of Technology and Health (STH), Environmental Physiology.
    Semicircular canal influence on the visually perceived eye level in pilots during centrifugation2011In: 82nd Annual Scientific Meeting of the Aerospace Medical Association, 2011Conference paper (Refereed)
  • 37.
    Tribukait, Arne
    et al.
    KTH, School of Technology and Health (STH), Environmental Physiology.
    Grönkvist, Mikael
    KTH, School of Technology and Health (STH), Environmental Physiology.
    Eiken, Ola
    KTH, School of Technology and Health (STH), Environmental Physiology.
    Betydelsen av flygerfarenhet för förmågan att uppfatta förändringar i pitch–position i gondolcentrifug/DFS2011In: Svenska Läkaresällskapets handlingar. Hygiea, 2011Conference paper (Refereed)
  • 38. Šarabon, N
    et al.
    Eiken, Ola
    KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Environmental Physiology. KTH, School of Technology and Health (STH), Centres, Swedish Aerospace Physiology Centre, SAPC.
    Mekjavic, IB
    Babič, J
    PlanHab: Effects of hypoxia and bed rest on postural stability2015Conference paper (Refereed)
  • 39. Šket, R
    et al.
    Treichel, N
    Debevec, T
    Eiken, Ola
    KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Environmental Physiology. KTH, School of Technology and Health (STH), Centres, Swedish Aerospace Physiology Centre, SAPC.
    Mekjavic, IB
    Schloter, M
    Stres, B
    PlanHab: Human intestinal microflora dynamics in normoxic and hypoxic bedrest studies2015Conference paper (Refereed)
1 - 39 of 39
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