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  • 1.
    Abtahi, Farhad
    et al.
    KTH, School of Technology and Health (STH). Karolinska Institute, Sweden.
    Anund, A.
    Fors, C.
    Seoane, Fernando
    KTH, School of Technology and Health (STH), Medical Engineering, Computer and Electronic Engineering. Karolinska Institute, Sweden.
    Lindecrantz, Kaj
    KTH, School of Technology and Health (STH), Medical Engineering, Computer and Electronic Engineering. Karolinska Institute, Sweden.
    Association of drivers’ sleepiness with heart rate variability: A pilot study with drivers on real roads2017In: EMBEC & NBC 2017, Springer, 2017, Vol. 65, p. 149-152Conference paper (Refereed)
    Abstract [en]

    Vehicle crashes lead to huge economic and social consequences, and one non-negligible cause of accident is driver sleepiness. Driver sleepiness analysis based on the monitoring of vehicle acceleration, steering and deviation from the road or physiological and behavioral monitoring of the driver, e.g., monitoring of yawning, head pose, eye blinks and eye closures, electroencephalogram, electrooculogram, electromyogram and electrocardiogram (ECG), have been used as a part of sleepiness alert systems. Heart rate variability (HRV) is a potential method for monitoring of driver sleepiness. Despite previous positive reports from the use of HRV for sleepiness detection, results are often inconsistent between studies. In this work, we have re-evaluated the feasibility of using HRV for detecting drivers’ sleepiness during real road driving. A database consists of ECG measurements from 10 drivers, driving during morning, afternoon and night sessions on real road were used. Drivers have reported their average sleepiness level by using the Karolinska sleepiness scale once every five minutes. Statistical analysis was performed to evaluate the potential of HRV indexes to distinguish between alert, first signs of sleepiness and severe sleepiness states. The results suggest that individual subjects show different reactions to sleepiness, which produces an individual change in HRV indicators. The results motivate future work for more personalized approaches in sleepiness detection.

  • 2. Abtahi, Farhad
    et al.
    Forsman, Mikael
    Diaz-Olivazrez, Jose A.
    KTH, School of Technology and Health (STH).
    Yang, Liyun
    KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Ergonomics.
    Lu, Ke
    KTH, School of Technology and Health (STH).
    Eklund, Jörgen
    KTH, School of Technology and Health (STH).
    Lindecrantz, Kaj
    KTH, School of Technology and Health (STH).
    Seoane, Fernando
    Teriö, Heikki
    Mediavilla Martinez, Cesar
    Aso, Santiago
    Tiemann, Christian
    Big Data & Wearable Sensors Ensuring Safety and Health @Work2017In: GLOBAL HEALTH 2017, The Sixth International Conference on Global Health Challenges, 2017Conference paper (Refereed)
    Abstract [en]

    —Work-related injuries and disorders constitute a major burden and cost for employers, society in general and workers in particular. We@Work is a project that aims to develop an integrated solution for promoting and supporting a safe and healthy working life by combining wearable technologies, Big Data analytics, ergonomics, and information and communication technologies. The We@Work solution aims to support the worker and employer to ensure a healthy working life through pervasive monitoring for early warnings, prompt detection of capacity-loss and accurate risk assessments at workplace as well as self-management of a healthy working life. A multiservice platform will allow unobtrusive data collection at workplaces. Big Data analytics will provide real-time information useful to prevent work injuries and support healthy working life

  • 3. Ahmed, Mona
    et al.
    Cerroni, Barbara
    Razuvaev, Anton
    Härmark, Johan
    KTH, School of Technology and Health (STH).
    Paradossi, Gaio
    Caidahl, Kenneth
    Gustafsson, Bjorn
    Cellular Uptake of Plain and SPION-Modified Microbubbles for Potential Use in Molecular Imaging2017In: Cellular and Molecular Bioengineering, ISSN 1865-5025, E-ISSN 1865-5033, Vol. 10, no 6, p. 537-548Article in journal (Refereed)
    Abstract [en]

    Both diagnostic ultrasound (US) and magnetic resonance imaging (MRI) accuracy can be improved by using contrast enhancement. For US gas-filled microbubbles (MBs) or silica nanoparticles (SiNPs), and for MRI superparamagnetic or paramagnetic agents, contribute to this. However, interactions of MBs with the vascular wall and cells are not fully known for all contrast media. We studied the in vitro interactions between three types of non-targeted air-filled MBs with a polyvinyl-alcohol shell and murine macrophages or endothelial cells. The three MB types were plain MBs and two types that were labelled (internally and externally) with superparamagnetic iron oxide nanoparticles (SPIONs) for US/MRI bimodality. Cells were incubated with MBs and imaged by microscopy to evaluate uptake and adhesion. Interactions were quantified and the MB internalization was confirmed by fluorescence quenching of non-internalized MBs. Macrophages internalized each MB type within different time frames: plain MBs 6 h, externally labelled MBs 25 min and internally labelled MBs 2 h. An average of 0.14 externally labelled MBs per cell were internalized after 30 min and 1.34 after 2 h; which was 113% more MBs than the number of internalized internally labelled MBs. The macrophages engulfed these three differently modified new MBs at various rate, whereas endothelial cells did not engulf MBs. Polyvinyl-alcohol MBs are not taken up by endothelial cells. The MB uptake by macrophages is promoted by SPION labelling, in particular external such, which may be important for macrophage targeting.

  • 4. Ahmed, Zara
    et al.
    Benque, David
    Berezin, Sergey
    Dahl, Anna Caroline E.
    KTH, School of Technology and Health (STH), Centres, Centre for Technology in Medicine and Health, CTMH.
    Fisher, Jasmin
    Hall, Benjamin A.
    Ishtiaq, Samin
    Nanavati, Jay
    Piterman, Nir
    Riechert, Maik
    Skoblov, Nikita
    Bringing LTL Model Checking to Biologists2017In: VMCAI 2017: Verification, Model Checking, and Abstract Interpretation / [ed] Bouajjani, A Monniaux, D, Springer, 2017, Vol. 10145, p. 1-13Conference paper (Refereed)
    Abstract [en]

    The BioModelAnalyzer (BMA) is a web based tool for the development of discrete models of biological systems. Through a graphical user interface, it allows rapid development of complex models of gene and protein interaction networks and stability analysis without requiring users to be proficient computer programmers. Whilst stability is a useful specification for testing many systems, testing temporal specifications in BMA presently requires the user to perform simulations. Here we describe the LTL module, which includes a graphical and natural language interfaces to testing LTL queries. The graphical interface allows for graphical construction of the queries and presents results visually in keeping with the current style of BMA. The Natural language interface complements the graphical interface by allowing a gentler introduction to formal logic and exposing educational resources.

  • 5.
    Akay, Altug
    KTH, School of Technology and Health (STH), Health Systems Engineering, Systems Safety and Management.
    A Novel Method to Intelligently Mine Social Media to Assess Consumer Sentiment of Pharmaceutical Drugs2017Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    This thesis focuses on the development of novel data mining techniques that convert user interactions in social media networks into readable data that would benefit users, companies, and governments. The readable data can either warn of dangerous side effects of pharmaceutical drugs or improve intervention strategies. A weighted model enabled us to represent user activity in the network, that allowed us to reflect user sentiment of a pharmaceutical drug and/or service. The result is an accurate representation of user sentiment. This approach, when modified for specific diseases, drugs, and services, can enable rapid user feedback that can be converted into rapid responses from consumers to industry and government to withdraw possibly dangerous drugs and services from the market or improve said drugs and services.

    Our approach monitors social media networks in real-time, enabling government and industry to rapidly respond to consumer sentiment of pharmaceutical drugs and services.

  • 6.
    Alaei, Zohreh
    KTH, School of Technology and Health (STH).
    Molecular Dynamics Simulations of Axonal Membrane in Traumatic Brain Injury2017Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    The following project presents in silico investigation of axonal damage in Diffuse Axonal Injury (DAI). When axons face a shear force, orientation of the lipids in the axonal membrane gets disrupted. Depending on the value of the force, a tensile strain causes the axons to get partially or fully deformed and in some cases a pore forms in the membrane. Using Molecular Dynamic (MD) simulation and a coarse grain model, a series of bilayers with various bilayer structure (single bilayer, parallel bilayer and cylindrical bilayer) and similar composition to biological axonal membrane were simulated. This was initially done to investigate the strain rate dependency of the bilayers, and their viscoelastic ability on returning to their original shape from their deformed forms. To achieve this, various deformation velocities were applied to the bilayers reaching 20% strain and relaxing the bilayer after. Additionally, the bilayers were deformed further until they reached a pore. It was found that the bilayers can almost recover from their deformed forms to their original length when they were deformed at 20% strain level. In conjunction, no correlation between the deformation velocity and lipid deformation was observed. Further, it was found that bilayers with different lipid percentage to axonal bilayer has different strain values for water penetration and for pore formation. The strain value for cylindrical bilayer was found very high compared to the strain values found in vitro. The strain for pore formation of parallel and single bilayer was found to be around 80% to 90% and for water penetration was found to be 70% for single bilayer and 50% for parallel bilayer. A slight difference in strain for pore formation between single and parallel bilayer was found which showed the bilayer structure can play a role in simulation results. The effect of the length in the simulations results was also observed where shorter bilayers showed lower strain for pore formation compared to longer bilayers. 

  • 7.
    Al-Battat, Ahmed
    et al.
    KTH, School of Technology and Health (STH), Medical Engineering, Computer and Electronic Engineering.
    Anwer, Noora
    KTH, School of Technology and Health (STH), Medical Engineering, Computer and Electronic Engineering.
    Utvärdering utifrån ett mjukvaruutveckling perspektiv av ramverk för SharePoint2017Independent thesis Basic level (university diploma), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The functionality was tested by two different tests, which showed that the product is suitable for usage in the intranet within a company or an organization, there are great benefits from using intranet as a tool for sharing of information. A good intranet contributes to a better flow of information and effective cooperation. SharePoint is a platform for intranet with interactive features, it makes the job easier for staff and even the company. The framework Omnia is a solution designed for Microsoft SharePoint 2013.This essay evaluates how Omnia acts as a framework and what the product is suitable for. Omnia framework evaluates carefully and is an independent assessment carried during this essay. The evaluation is based on scientific studies which are based on the qualitative and quantitative research methodology. The evaluator's main areas are based on system performance, scalability, architecture and functionality. A test prototype develops during the process in the form of an employee vacation request application by the development framework Omnia.The framework Omnia is considered to be suitable for the development of interactive web-based applications for SharePoint. The architecture for the system meets the requirements for scalable systems because it is based on the tier architecture. The system also has good performance but it needs to be improved if the number of users exceeds one thousand. The functionality of this product is quite suitable for the system's usage.

  • 8.
    Andersson, Andreas
    KTH, School of Technology and Health (STH), Medical Engineering, Computer and Electronic Engineering.
    Spirometri med en smarttelefon: Utveckling av en app för att mäta rotationshastigheten till en spirometerprototyp för smarttelefoner2017Independent thesis Basic level (university diploma), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The goal with this bachelor thesis was to develop an application with an algorithm to measure the rotation speed of a prototype, as a low-cost solution for measuring spirometry with a smartphone. In a pilot study it was investigated how a smartphone can be used to measure health and what algorithms there are to detect motion in videos. After the pilot study an app with the function to record a video by using the camera of a smartphone and then use an algorithm to detect the rotation speed in the spirometry-prototype’s turbine was developed. To make it work it is important that the rotation speed is low enough so it does not exceed half of the cameras fps. Therefore, to capture the rotation speed of the spirometry-prototype’s turbine the rotation needs to be limited and a smartphone with a camera with at least 120 fps is required.The result of this work is an algorithm that can measure the rotation speed in the spirometry prototype turbine. The algorithm is detecting the peaks in a PPG. To minimize the computation time and to increase the accuracy the algorithm analyses the colour intensity over a ROI in every frame. There is great potential to use this algorithm to further develop this alternative method of measuring spirometry.

  • 9.
    Andersson, Elin
    et al.
    KTH, School of Technology and Health (STH).
    Filipsson, Emma
    KTH, School of Technology and Health (STH).
    Upphandling av medicintekniska produkter inom sjukvården i Sverige2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Since 1994, the Public Procurement Act has undergone changes aimed to improve the procurement process and promoting innovation. In order to promote innovation there are a number of government agencies that offer financial assistance, especially to small business with innovative ideas. Despite these efforts, newly established small businesses have difficulties entering the market.

    The study investigates whether changes have been made in the public procurement of medical devices with regard to price and quality prioritization. The priority criteria is presented by the contracting authority as percentage in the allocation criteria. The study is limited to in vitro diagnostic products contracting in Swedish healthcare between the years 2009 and 2015. All tenders, companies that apply for participation in procurement, were analyzed based on sales, number of employees and year of establishment with the purpose of evaluating differences between winning tenders and other tenders.

    The result shows that prioritization has been increasingly on price rather than the quality. Regarding the winning tenders the study shows that larger, more established companies dominates the market. Noteworthy is that this dominance has increased over theses last years. The increase may be due to a spiral effect that is created when winning tenders get an increased economic power. 

  • 10. Andersson, Marlene
    et al.
    Jia, Qiupin
    Abella, Ana
    Lee, Xiau-Yeen
    Landreh, Michael
    Purhonen, Pasi
    KTH, School of Technology and Health (STH).
    Hebert, Hans
    KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Structural Biotechnology.
    Tenje, Maria
    Robinson, Carol V.
    Meng, Qing
    Plaza, Gustavo R.
    Johansson, Jan
    Rising, Anna
    Biomimetic spinning of artificial spider silk from a chimeric minispidroin2017In: Nature Chemical Biology, ISSN 1552-4450, E-ISSN 1552-4469, Vol. 13, no 3, p. 262-+Article in journal (Refereed)
    Abstract [en]

    Herein we present a chimeric recombinant spider silk protein (spidroin) whose aqueous solubility equals that of native spider silk dope and a spinning device that is based solely on aqueous buffers, shear forces and lowered pH. The process recapitulates the complex molecular mechanisms that dictate native spider silk spinning and is highly efficient; spidroin from one liter of bacterial shake-flask culture is enough to spin a kilometer of the hitherto toughest as-spun artificial spider silk fiber.

  • 11.
    Andersson, Olle
    KTH, School of Technology and Health (STH).
    Characterization of an On-chip Photonic Waveguide gas Sensor2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Gas sensing in medical applications requiresmall, precise and sensitive sensors. This projecthas developed a laboratory setup for characterisationof a waveguide-based gas sensor for carbon dioxide andmethane working in the mid-IR range of 2 - 10 μm. Thissetup utilizes an IR-camera to image the waveguideswhen a mid-IR laser is coupled into them. Along thelaboratory work, a program for optimisation of waveguidelength has been made and a study of on-marketmedical carbon dioxide sensors has been done. Thelaboratory setup shows potential for good measurementof waveguide losses, but several problems was identifiedwith the measurement methods currently used. Fromthe sensor study, the standard performance for currentsensors is presented as well as areas where gas sensorscould be improved. Size, speed and accuracy were someof the characteristics a waveguide-based sensor couldimprove on and open up for new sensor application in,for example, hand-held medical devices.

  • 12.
    Andreasson, Jörgen
    et al.
    KTH, School of Technology and Health (STH), Health Systems Engineering, Ergonomics.
    Ahlstrom, Linda
    Eriksson, Andrea
    KTH, School of Technology and Health (STH), Health Systems Engineering, Ergonomics.
    Dellve, Lotta
    KTH, School of Technology and Health (STH), Health Systems Engineering, Ergonomics.
    The importance of healthcare managers’ organizational preconditions and support resources for their appraisal of planned change and its outcomes2017In: Journal of Hospital Administration, ISSN 1927-6990, E-ISSN 1927-7008, Vol. 6, no 1Article in journal (Refereed)
    Abstract [en]

    Background: Healthcare managers are expected to lead and manage planned organizational change intended to improve healthcare process quality. However, their complex working conditions offer limited decision control, and healthcare managers often feel ill prepared and inadequately supported to perform their duties. Healthcare managers have previously described their need for organizational support, but we lack knowledge of the preconditions and resources that help managers implement planned change.Methods: This prospective cohort study examined healthcare managers at three Swedish hospitals implementing lean production and two Swedish hospitals implementing their own improvement model. Questionnaire data from 2012, 2103, and 2014 were used in following up. We used t-tests and a linear mixed model design in analysing the data.Results: Healthcare managers who perceived strong support from managers, employees, colleagues, and the organization and managers with the longest managerial experience had the least negative appraisal of change. Managers who perceived strong support from employees, management, and the organizational structure perceived higher levels of healthcare process quality.Conclusions: Long managerial experience and strong support from managers, employees, and the organization are important formanagers’ appraisal of, work on, and successful implementation of planned change. Top management must therefore ensure that the healthcare managers have sufficient managerial experience and support before they delegate to them the responsibility to implement planned change.

  • 13.
    Araya, Cristian
    et al.
    KTH, School of Technology and Health (STH), Medical Engineering, Computer and Electronic Engineering.
    Singh, Manjinder
    KTH, School of Technology and Health (STH), Medical Engineering, Computer and Electronic Engineering.
    Web API protocol and security analysis2017Independent thesis Basic level (university diploma), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    There is problem that every company has its own customer portal. This problem can be solved by creating a platform that gathers all customers’ portals in one place. For such platform, it is required a web API protocol that is fast, secure and has capacity for many users. Consequently, a survey of various web API protocols has been made by testing their performance and security.

    The task was to find out which web API protocol offered high security as well as high performance in terms of response time both at low and high load. This included an investigation of previous work to find out if certain protocols could be ruled out. During the work, the platform’s backend was also developed, which needed to implement chosen web API protocols that would later be tested. The performed tests measured the APIs’ connection time and their response time with and without load. The results were analyzed and showed that the protocols had both pros and cons. Finally, a protocol was chosen that was suitable for the platform because it offered high security and fast connection. In addition, the server was not affected negatively by the number of connections. Reactive REST was the web API protocol chosen for this platform.

  • 14.
    B. Kumar, Ramakrishnan
    et al.
    Karolinska institutet, Sverige.
    Zhu, Lin
    KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Structural Biotechnology.
    Hebert, Hans
    KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Structural Biotechnology. Karolinska institutet, Sverige.
    Jegerschöld, Caroline
    Karolinska institutet, Sverige.
    Method to Visualize and Analyze Membrane Interacting Proteins by Transmission Electron Microscopy2017In: Journal of Visualized Experiments, ISSN 1940-087X, E-ISSN 1940-087X, no 121, article id e55148Article in journal (Refereed)
    Abstract [en]

    Monotopic proteins exert their function when attached to a membrane surface, and such interactions depend on the specific lipid composition and on the availability of enough area to perform the function. Nanodiscs are used to provide a membrane surface of controlled size and lipid content. In the absence of bound extrinsic proteins, sodium phosphotungstate-stained nanodiscs appear as stacks of coins when viewed from the side by transmission electron microscopy (TEM). This protocol is therefore designed to intentionally promote stacking; consequently, the prevention of stacking can be interpreted as the binding of the membrane-binding protein to the nanodisc. In a further step, the TEM images of the protein-nanodisc complexes can be processed with standard single-particle methods to yield low-resolution structures as a basis for higher resolution cryoEM work. Furthermore, the nanodiscs provide samples suitable for either TEM or non-denaturing gel electrophoresis. To illustrate the method, Ca2+-induced binding of 5-lipoxygenase on nanodiscs is presented.

  • 15.
    Bennati, Paolo
    et al.
    KTH, School of Technology and Health (STH), Medical Engineering.
    Dasu, A.
    Colarieti-Tosti, Massimiliano
    KTH, School of Technology and Health (STH), Medical Engineering, Medical Imaging.
    Lönn, Gustaf
    KTH, School of Technology and Health (STH), Medical Engineering.
    Larsson, David
    KTH, School of Technology and Health (STH), Medical Engineering, Medical Imaging.
    Fabbri, A.
    Galasso, M.
    Cinti, M. N.
    Pellegrini, R.
    Pani, R.
    Preliminary study of a new gamma imager for on-line proton range monitoring during proton radiotherapy2017In: Journal of Instrumentation, ISSN 1748-0221, E-ISSN 1748-0221, Vol. 12, no 5, article id C05009Article in journal (Refereed)
    Abstract [en]

    We designed and tested new concept imaging devices, based on a thin scintillating crystal, aimed at the online monitoring of the range of protons in tissue during proton radiotherapy. The proposed crystal can guarantee better spatial resolution and lower sensitivity with respect to a thicker one, at the cost of a coarser energy resolution. Two different samples of thin crystals were coupled to a position sensitive photo multiplier tube read out by 64 independent channels electronics. The detector was equipped with a knife-edge Lead collimator that defined a reasonable field of view of about 10 cm in the target. Geant4 Monte Carlo simulations were used to optimize the design of the experimental setup and assess the accuracy of the results. Experimental measurements were carried out at the Skandion Clinic, the recently opened proton beam facility in Uppsala, Sweden. PMMA and water phantoms studies were performed with a first prototype based on a round 6.0 mm thick Cry019 crystal and with a second detector based on a thinner 5 × 5 cm2, 2.0 mm thick LFS crystal. Phantoms were irradiated with mono-energetic proton beams whose energy was in the range between 110 and 160 MeV. According with the simulations and the experimental data, the detector based on LFS crystal seems able to identify the peak of prompt-gamma radiation and its results are in fair agreement with the expected shift of the proton range as a function of energy. The count rate remains one of the most critical limitations of our system, which was able to cope with only about 20% of the clinical dose rate. Nevertheless, we are confident that our study might provide the basis for developing a new full-functional system.

  • 16.
    Bjering, Beatrice
    et al.
    KTH, School of Technology and Health (STH).
    Forss, Elin
    KTH, School of Technology and Health (STH).
    Videoanalys av sekvenser i ishockey där en tackling resulterat i hjärnskakning2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    There is a major issue with concussion within contact sports and one of these sports is ice hockey. Concussions have a negative effect on health and repeated concussions, which often occur in ice hockey, can force players to retire early. Since it is such a major problem that can result in serious consequences, a better understanding within the field is needed. This report has focused on speeds right before a player was tackled as well as the players contact body parts. The information was collected by analyzing 10 video clips where a tackle took place that resulted in a concussion. The video clips were analyzed using the software SkillSpector, where 3D speeds were collected for both the attacking and the injured players. The contact body parts were also identified during the analysis. The results were compared to a reference group from an earlier bachelor degree project where tackles that did not result in a concussion were analyzed. The conclusion from this project is that the speeds for the players in the interest group were proven to have a significantly higher mean speed than the players from the earlier project. Furthermore, the results indicate that the tackled players speed can have a larger impact on the outcome of the tackle than the speed of the attacking player. From the results in this project it is shown that, of the tackles that could lead to a concussion, shoulder to jaw was the most common combination.

  • 17. Blogg, S. Lesley
    et al.
    Mollerlokken, Andreas
    Gennser, Mikael
    KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Environmental Physiology.
    Observed decompression sickness and venous bubbles following 18-msw dive profiles using RN Table 112017In: Undersea & Hyperbaric Medicine, ISSN 1066-2936, Vol. 44, no 3, p. 211-219Article in journal (Refereed)
    Abstract [en]

    The venous bubble load in the body after diving may be used to infer risk of decompression sickness (DCS). Retrospective analysis of post-dive bubbling and DCS was made on seven studies. Each of these investigated interventions, using an 18 meters of sea water (msw) air dive profile from Royal Navy Table 11 (Mod Air Table), equivalent to the Norwegian Air tables. A recent neurological DCS case suggested this table was not safe as thought. Two-hundred and twenty (220) man-dives were completed on this profile. Bubble measurements were made following 219 man-dives, using Doppler or 2D ultrasound measurements made on the Kisman-Masurel and Eftedal-Brubakk scales, respectively. The overall median grade was KM/EB 0.5 and the overall median maximum grade was KM/EB 2. Two cases of transient shoulder discomfort ("niggles") were observed (0.9% (95% CL 0.1% 3.3%)) and were treated with surface oxygen. One dive, for which no bubble measurements were made, resulted in a neurological DCS treated with hyperbaric oxygen. The DCS risk of this profile is below that predicted by models, and comparison of the cumulative incidence of DCS of these data to the large dataset compiled by DCIEM [1, 2], show that the incidence is lower than might be expected.

  • 18. Blogg, SL
    et al.
    Møllerløkken, A
    Gennser, Mikael
    KTH, School of Technology and Health (STH), Environmental Physiology.
    Response: car wrecks and caution: a lament on getting the facts straight in scientific reporting.2017In: Undersea Hyperb Med, Vol. 44, p. 492-494Article in journal (Other (popular science, discussion, etc.))
  • 19. Blystad, Ida
    et al.
    Warntjes, J. B. Marcel
    Smedby, Örjan
    KTH, School of Technology and Health (STH), Medical Engineering, Medical Image Processing and Visualization. Linköping University, Sweden.
    Lundberg, Peter
    Larsson, Elna-Marie
    Tisell, Anders
    Quantitative MRI for analysis of peritumoral edema in malignant gliomas2017In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 12, no 5, article id e0177135Article in journal (Refereed)
    Abstract [en]

    Background and purpose Damage to the blood-brain barrier with subsequent contrast enhancement is a hallmark of glioblastoma. Non-enhancing tumor invasion into the peritumoral edema is, however, not usually visible on conventional magnetic resonance imaging. New quantitative techniques using relaxometry offer additional information about tissue properties. The aim of this study was to evaluate longitudinal relaxation R-1, transverse relaxation R-2, and proton density in the peritumoral edema in a group of patients with malignant glioma before surgery to assess whether relaxometry can detect changes not visible on conventional images. Methods In a prospective study, 24 patients with suspected malignant glioma were examined before surgery. A standard MRI protocol was used with the addition of a quantitative MR method (MAGIC), which measured R-1, R-2, and proton density. The diagnosis of malignant glioma was confirmed after biopsy/surgery. In 19 patients synthetic MR images were then created from the MAGIC scan, and ROIs were placed in the peritumoral edema to obtain the quantitative values. Dynamic susceptibility contrast perfusion was used to obtain cerebral blood volume (rCBV) data of the peritumoral edema. Voxel-based statistical analysis was performed using a mixed linear model. Results R-1, R-2, and rCBV decrease with increasing distance from the contrast-enhancing part of the tumor. There is a significant increase in R1 gradient after contrast agent injection (P<.0001). There is a heterogeneous pattern of relaxation values in the peritumoral edema adjacent to the contrast-enhancing part of the tumor. Conclusion Quantitative analysis with relaxometry of peritumoral edema in malignant gliomas detects tissue changes not visualized on conventional MR images. The finding of decreasing R-1 and R-2 means shorter relaxation times closer to the tumor, which could reflect tumor invasion into the peritumoral edema. However, these findings need to be validated in the future.

  • 20. Bora, Kangkana
    et al.
    Chowdhury, Manish
    KTH, School of Technology and Health (STH).
    Mahanta, Lipi B.
    Kundu, Malay Kumar
    Das, Anup Kumar
    Automated classification of Pap smear images to detect cervical dysplasia2017In: Computer Methods and Programs in Biomedicine, ISSN 0169-2607, E-ISSN 1872-7565, Vol. 138, p. 31-47Article in journal (Refereed)
    Abstract [en]

    Background and objectives: The present study proposes an intelligent system for automatic categorization of Pap smear images to detect cervical dysplasia, which has been an open problem ongoing for last five decades. Methods: The classification technique is based on shape, texture and color features. It classifies the cervical dysplasia into two-level (normal and abnormal) and three-level (Negative for Intraepithelial Lesion or Malignancy, Low-grade Squamous Intraepithelial Lesion and High-grade Squamous Intraepithelial Lesion) classes reflecting the established Bethesda system of classification used for diagnosis of cancerous or precancerous lesion of cervix. The system is evaluated on two generated databases obtained from two diagnostic centers, one containing 1610 single cervical cells and the other 1320 complete smear level images. The main objective of this database generation is to categorize the images according to the Bethesda system of classification both of which require lots of training and expertise. The system is also trained and tested on the benchmark Herlev University database which is publicly available. In this contribution a new segmentation technique has also been proposed for extracting shape features. Ripplet Type I transform, Histogram first order statistics and Gray Level Co-occurrence Matrix have been used for color and texture features respectively. To improve classification results, ensemble method is used, which integrates the decision of three classifiers. Assessments are performed using 5 fold cross validation. Results: Extended experiments reveal that the proposed system can successfully classify Pap smear images performing significantly better when compared with other existing methods. Conclusion: This type of automated cancer classifier will be of particular help in early detection of cancer.

  • 21.
    Borromeo, Reenalyn
    et al.
    KTH, School of Technology and Health (STH).
    Emil, Olsson
    KTH, School of Technology and Health (STH).
    Utvärdering av kompensationsmetoder för virvelströmmar i magnetisk resonanstomografi med bSSFP2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Den mest etablerade metoden för hjärtavbildning med MRI kallas bSSFP. Denna baseras på att signalen hålls i ett jämviktstillstånd genom noggrann balansering av magnetiska gradientfält. Vid avbildning av objekt i rörelse med hög temporal upplösning sker snabba skiftningar av gradienterna som inducerar virvelströmmar i magnetkamerans ledande komponenter och i patienten. Virvelströmmarna som skapas stör det homogena statiska fältet som krävs för avbildning med bSSFP och leder till artefakter vid avbildning.

    Det finns därför ett intresse i att kompensera för virvelströmmarnas påverkan vid avbildning. I detta arbete utvärderas tre befintliga kompensationsmetoder: ”Tiny Golden Angle”, ”Double Averaging” och ”Through Slice Equlibriation”. Respektive metod tillåter olika parameterval. Målet med detta arbete är att avgöra vilken, eller vilka, kombinationer av metoderna som ger bäst kompensation för virvelströmmar utan att påverka bildernas kliniska värde. Undersökningen baserades på att kombinera olika metoder samt parametervärden hos respektive metod och applicera detta vid avbildning av ett fantom. Sedan gjordes en kvantitativ analys av fantombilderna och baserat på fantomstudien skedde ett urval av kombinationer för hjärtavbildning av en frivillig testperson. En visuell bedömning gjordes sedan på hjärtbilderna.

    Resultatet tydde på att individuell applicering av metoderna kompenserade för virvelströmmar, men även att vissa kombinationer av dessa bidrog med förbättrad bildkvalitet. Samtliga bilder bedömdes vara av klinisk kvalitet och resultatet av detta arbete öppnar möjligheten för en klinisk valideringsstudie.

  • 22. Bramberg, Elisabeth Bjork
    et al.
    Nyman, Teresia
    KTH, School of Technology and Health (STH), Health Systems Engineering, Ergonomics. Unit of Intervention and Implementation Research for Worker Health, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Medical Sciences, Occupational and Environmental Medicine, Uppsala University, Uppsala, Sweden.
    Kwak, Lydia
    Alipour, Akbar
    Bergstrom, Gunnar
    Elinder, Liselotte Schafer
    Hermansson, Ulric
    Jensen, Irene
    Development of evidence-based practice in occupational health services in Sweden: a 3-year follow-up of attitudes, barriers and facilitators2017In: International Archives of Occupational and Environmental Health, ISSN 0340-0131, E-ISSN 1432-1246, Vol. 90, no 4, p. 335-348Article in journal (Refereed)
    Abstract [en]

    The Swedish government initiated an investigation of how to secure and develop the competence of the occupational health services. The primary aim of the present study was to investigate whether the development of evidence-based practice (EBP) in the Swedish occupational health services in relation to attitudes, knowledge and use improved during the first 3 years of the government's initiative. The study has a mixed methods design combining questionnaires and interviews with data collection at baseline and at 3-year follow-up. The response rate was 66% at baseline and 63% at follow-up. The results show that practitioners' knowledge of EBP was moderate at baseline and improved at follow-up (p = 0.002; 95% CI 0.01; 0.21). Practitioners experienced lower levels of organizational and managerial support for EBP at follow-up (p < 0.001; 95% CI 0.18; 0.38). The results revealed that managers viewed responsibility for implementing EBP as a matter for individual practitioners rather than as an organizational issue. Occupational health service managers and practitioners are generally positive to EBP. However, the findings emphasize the need to educate managers in how to support EBP at the organizational level by creating an infrastructure for EBP in the OHS.

  • 23.
    Buizza, Giulia
    KTH, School of Technology and Health (STH).
    Classifying patients' response to tumour treatment from PET/CT data: a machine learning approach2017Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Early assessment of tumour response has lately acquired big interest in the medical field, given the possibility to modify treatments during their delivery. Radiomics aims to quantitatively describe images in radiology by automatically extracting a large number of image features. In this context, PET/CT (Positron Emission Tomography/Computed Tomography) images are of great interest since they encode functional and anatomical information, respectively. In order to assess the patients' responses from many image features appropriate methods should be applied. Machine learning offers different procedures that can deal with this, possibly high dimensional, problem.

    The main objective of this work was to develop a method to classify lung cancer patients as responding or not to chemoradiation treatment, relying on repeated PET/CT images. Patients were divided in two groups, based on the type of chemoradiation treatment they underwent (sequential or concurrent radiation therapy with respect to chemotherapy), but image features were extracted using the same procedure. Support vector machines performed classification using features from the Radiomics field, mostly describing tumour texture, or from handcrafted features, which described image intensity changes as a function of tumour depth. Classification performance was described by the area under the curve (AUC) of ROC (Receiving Operator Characteristic) curves after leave-one-out cross-validation. For sequential patients, 0.98 was the best AUC obtained, while for concurrent patients 0.93 was the best one. Handcrafted features were comparable to those from Radiomics and from previous studies, as for classification results. Also, features from PET alone and CT alone were found to be suitable for the task, entailing a performance better than random.

  • 24.
    Callerström, Emma
    KTH, School of Technology and Health (STH).
    Clinicians' demands on monitoring support in an Intensive Care Unit: A pilot study, at Capio S:t Görans Hospital2017Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Patients treated at intensive care units (ICUs) are failing in one or several organs and requireappropriate monitoring and treatment in order to maintain a meaningful life. Today clinicians inintensive care units (ICUs) manage a large amount of data generated from monitoring devices.The monitoring parameters can either be noted down manually on a monitoring sheet or, for some parameters, transferred automatically to storage. In both cases the information is stored withthe aim to support clinicians throughout the intensive care and be easily accessible. Patient datamanagement systems (PDMSs) facilitate ICUs to retrieve and integrate data. Before managinga new configuration of patient data system, it is required that the ICU makes careful analysis ofwhat data desired to be registered. This pilot study provides knowledge of how the monitoringis performed in an Intensive Care Unit in an emergency hospital in Stockholm.The aim of this thesis project was to collect data about what the clinicians require and whatequipment they use today for monitoring. Requirement elicitation is a technique to collectrequirements. Methods used to collect data were active observations and qualitative interviews.Patterns have been found about what the assistant nurses, nurses and physicians’ require of systems supporting the clinician’s with monitoring parameters. Assistant nurses would like tobe released from tasks of taking notes manually. They also question the need for atomized datacollection since they are present observing the patient bed-side. Nurses describe a demanding burden of care and no more activities increasing that burden of care is required. Physicians require support in order to see how an intervention leads to a certain result for individual patients.The results also show that there is information about decision support but no easy way to applythem, better than the ones used today. Clinicians state that there is a need to be able to evaluatethe clinical work with the help of monitoring parameters. The results provide knowledge about which areas the clinicians needs are not supported enough by the exciting tools.To conclude results show that depending on what profession and experience the clinicians have the demands on monitoring support di↵ers. Monitoring at the ICU is performed while observing individual patients, parameters from medical devices, results from medical tests and physical examinations. Information from all these sources is considered by the clinicians and is desired to be supported accordingly before clinicians commit to action resulting in certain treatment,diagnosis and/or care.

  • 25.
    Callert Jakobsson, Helene
    KTH, School of Technology and Health (STH), Health Systems Engineering, Ergonomics.
    Rätt från början: Att verka för användbara och tillgängliga lokaler inom hälso- och sjukvård2017Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Abstract

    Occupational injuries are a problem in healthcare in Sweden. Both occupational accidents and most of all occupational diseases caused by great physical workloads constitute a large proportion of work related musculoskeletal disorders (MSD) of healthcare professionals. The aim of the study was to explore and describe the work process in the design teams of the building design process. The main focus was the building design process of health care buildings and the design teams where ergonomists and safety engineers are asked to participate. The purpose was to create a knowledge base consisting of this study and an appendix with methods and relevant literature. Eight people with different professions were interview. All of them had a good hold on the building design processes and on hospital architecture issues. Among them there were two ergonomists and two safety engineers. The result indicates that ergonomists and safety engineers were those who possessed the knowledge of working environment factors such as ergonomics in the building design processes. The methodology was to follow the agreed plan for the building design process established by the project Manager. Moreover the role of the ergonomists and safety engineers in the design team was to coach and supervise particularly the healthcare professionals. The main approach was to create a good dialogue and conversation and to keep a solution-oriented approach in the design team. Furthermore the most important method was to visualize drawings of Architects which made it possible for the healthcare workers to be able to audit the drawings correctly. This procedure gave the healthcare professionals a decision-making support which helped them to make well-reasoned decisions about their future work environment. The conclusion indicates that ergonomists and safety engineers are important because of their unique knowledge of working environment, especially ergonomics. Ergonomists and safety engineers need to be involved in the early phases of the building design process in order to be able to influence the design of new workspaces. The participation of these two professions in the design team may also benefit the healthcare workers with a future work environment which is largely designed according to their requirements and needs and will probably help to prevent MSDs. In the future there is a need for a specific education just for the ergonomists and the safety engineers participating in the building design process of healthcare buildings. There are great opportunities for them to develop their role towards a more prominent one in the building design process.

    Keywords: Ergonomists, safety engineers, building design process, health care architecture, methods, procedures

  • 26.
    Charalampidis, Vasileios
    KTH, School of Technology and Health (STH).
    Real-Time Monitoring System of Sedentary Behavior with Android Wear and Cloud Computing: An office case study2017Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Nowadays, prolonged sitting among office workers is a widespread problem, which is highly related to several health problems. Many proposals have been reported and evaluated to address this issue. However, motivating and engaging workers to change health behavior to a healthier working life is still a challenge.

    In this project, a specific application has been deployed for real-time monitoring and alerting office workers for prolonged sitting. The proposed system consists of three distinct parts: The first one is an android smartwatch, which was used to collect sensor data e.g., accelerometer and gyro data, with a custom android wear app. The second one is an android application, which was developed to act as a gateway for receiving the smartwatch’s data and sending them to IBM Bluemix cloud with MQTT protocol. The final part is a Node-Red cloud application, which was deployed for storing, analyzing and processing of the sensor data for activity detection i.e., sitting or walking/standing. The main purpose of the last one was to return relevant feedback to the user, while combining elements from gaming contexts (gamification methods), for motivating and engaging office workers to a healthier behavior.

    The system was firstly tested for defining appropriate accelerometer thresholds to five participants (control group), and then evaluated with five different participants (treatment group), in order to analyze its reliability for prolonged sitting detection. The results showed a good precession for the detection. No confusing between sitting and walking/standing was noticed. Communication, storage and analysis of the data was successfully done, while the push notifications to the participants, for alerting or rewarding them, were always accurate and delivered on time. Every useful information was presented to the user to a web-based dashboard accessed through a smartphone, tablet or a PC.    

    The proposed system can easily be implemented at a real-life scenario with office workers. Certainly, there is a lot space for improvement, considering mostly the type of data registered at the system, the method for sitting detection, and the user interface for presenting relevant information.

  • 27.
    Chen, Fengnong
    et al.
    KTH, School of Technology and Health (STH). College of Life Information Science & Instrument Engineering, Hangzhou Dianzi University, Hangzhou 310018, China.
    Chen, Pulan
    Muhammed, Hamed Hamid
    KTH, School of Technology and Health (STH).
    Zhang, Juan
    Intravoxel Incoherent Motion Diffusion for Identification of Breast Malignant and Benign Tumors Using Chemometrics2017In: BioMed Research International, ISSN 2314-6133, E-ISSN 2314-6141, article id 3845409Article in journal (Refereed)
    Abstract [en]

    Theaim of the paper is to identify the breast malignant and benign lesions using the features of apparent diffusion coefficient (ADC), perfusion fraction f, pseudodiffusion coefficient D*, and true diffusion coefficient D from intravoxel incoherent motion (IVIM). There are 69 malignant cases (including 9 early malignant cases) and 35 benign breast cases who underwent diffusion-weighted MRI at 3.0 T with 8 b-values (0 similar to 1000 s/mm(2)). ADC and IVIM parameters were determined in lesions. The early malignant cases are used as advanced malignant and benign tumors, respectively, so as to assess the effectiveness on the result. A predictive model was constructed using Support VectorMachine Binary Classification (SVMBC, also known Support VectorMachine Discriminant Analysis (SVMDA)) and Partial Least Squares Discriminant Analysis (PLSDA) and compared the difference between them both. The.. value and ADC provide accurate identification of malignant lesions with.. = 300, if early malignant tumor was considered as advanced malignant (cancer). The classification accuracy is 93.5% for cross-validation using SVMBC with ADC and tissue diffusivity only. The sensitivity and specificity are 100% and 87.0%, respectively, r(2) (cv) = 0.8163, and root mean square error of cross-validation (RMSECV) is 0.043. ADC and IVIM provide quantitative measurement of tissue diffusivity for cellularity and are helpful with the method of SVMBC, getting comprehensive and complementary information for differentiation between benign and malignant breast lesions.

  • 28. Chen, Gefei
    et al.
    Abelein, Axel
    Nilsson, Harriet E.
    KTH, School of Technology and Health (STH), Medical Engineering, Structural Biotechnology.
    Leppert, Axel
    Andrade-Talavera, Yuniesky
    Tambaro, Simone
    Hemmingsson, Lovisa
    Roshan, Firoz
    Landreh, Michael
    Biverstal, Henrik
    Koeck, Philip J. B.
    KTH, School of Technology and Health (STH), Medical Engineering, Structural Biotechnology.
    Presto, Jenny
    Hebert, Hans
    Fisahn, Andre
    Johansson, Jan
    Bri2 BRICHOS client specificity and chaperone activity are governed by assembly state2017In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 8, article id 2081Article in journal (Refereed)
    Abstract [en]

    . Protein misfolding and aggregation is increasingly being recognized as a cause of disease. In Alzheimer's disease the amyloid-beta peptide (A beta) misfolds into neurotoxic oligomers and assembles into amyloid fibrils. The Bri2 protein associated with Familial British and Danish dementias contains a BRICHOS domain, which reduces A beta fibrillization as well as neurotoxicity in vitro and in a Drosophila model, but also rescues proteins from irreversible nonfibrillar aggregation. How these different activities are mediated is not known. Here we show that Bri2 BRICHOS monomers potently prevent neuronal network toxicity of A beta, while dimers strongly suppress A beta fibril formation. The dimers assemble into high-molecular-weight oligomers with an apparent two-fold symmetry, which are efficient inhibitors of non-fibrillar protein aggregation. These results indicate that Bri2 BRICHOS affects qualitatively different aspects of protein misfolding and toxicity via different quaternary structures, suggesting a means to generate molecular chaperone diversity.

  • 29. Chowdhury, Helena H
    et al.
    Velebit, Jelena
    Mekjavic, Igor B
    Eiken, Ola
    KTH, School of Technology and Health (STH), Environmental Physiology. KTH, School of Technology and Health (STH), Centres, Swedish Aerospace Physiology Centre, SAPC.
    Kreft, Marko
    Zorec, Robert
    Systemic Hypoxia Increases the Expression of DPP4 in Preadipocytes of Healthy Human Participants2017In: Experimental and clinical endocrinology & diabetes, ISSN 0947-7349, E-ISSN 1439-3646Article in journal (Refereed)
    Abstract [en]

    Dipeptidyl peptidase 4 (DPP4) is a transmembrane glycoprotein involved in protein degradation. Due to its action on incretins, which increase insulin secretion, DPP4 is considered a therapeutic target for type 2 diabetes. Here we have studied the role of single and combined effects of hypoxia and inactivity on the expression of DPP4 in human adipose tissue of 12 adult normal-weight males. Fat biopsies were obtained at baseline and after each of three experimental campaigns. The results revealed that in isolated human preadipocytes the expression of DPP4 was significantly increased by exposure of participants to hypoxia. Physical inactivity per se had no apparent effect on the DPP4 expression. It is concluded that DPP4 may be a marker to monitor indirectly tissue hypoxia, as occurs in obese subjects.

  • 30.
    Chowdhury, Manish
    et al.
    KTH, School of Technology and Health (STH).
    Jörgens, Daniel
    KTH, School of Technology and Health (STH), Medical Engineering, Medical Image Processing and Visualization.
    Wang, Chunliang
    KTH, School of Technology and Health (STH), Medical Engineering, Medical Image Processing and Visualization. KTH, School of Technology and Health (STH), Medical Engineering, Medical Imaging.
    Smedby, Örjan
    KTH, School of Technology and Health (STH), Medical Engineering, Medical Image Processing and Visualization.
    Moreno, Rodrigo
    KTH, School of Technology and Health (STH), Medical Engineering, Medical Image Processing and Visualization.
    Segmentation of Cortical Bone using Fast Level Sets2017In: MEDICAL IMAGING 2017: IMAGE PROCESSING / [ed] Styner, MA Angelini, ED, SPIE - International Society for Optical Engineering, 2017, article id UNSP 1013327Conference paper (Refereed)
    Abstract [en]

    Cortical bone plays a big role in the mechanical competence of bone. The analysis of cortical bone requires accurate segmentation methods. Level set methods are usually in the state-of-the-art for segmenting medical images. However, traditional implementations of this method are computationally expensive. This drawback was recently tackled through the so-called coherent propagation extension of the classical algorithm which has decreased computation times dramatically. In this study, we assess the potential of this technique for segmenting cortical bone in interactive time in 3D images acquired through High Resolution peripheral Quantitative Computed Tomography (HR-pQCT). The obtained segmentations are used to estimate cortical thickness and cortical porosity of the investigated images. Cortical thickness and Cortical porosity is computed using sphere fitting and mathematical morphological operations respectively. Qualitative comparison between the segmentations of our proposed algorithm and a previously published approach on six images volumes reveals superior smoothness properties of the level set approach. While the proposed method yields similar results to previous approaches in regions where the boundary between trabecular and cortical bone is well defined, it yields more stable segmentations in challenging regions. This results in more stable estimation of parameters of cortical bone. The proposed technique takes few seconds to compute, which makes it suitable for clinical settings.

  • 31.
    Chowdhury, Manish
    et al.
    KTH, School of Technology and Health (STH).
    Klintström, Benjamin
    KTH, School of Technology and Health (STH). Linköping University, Sweden.
    Klintström, E.
    Smedby, Örjan
    KTH, School of Technology and Health (STH), Medical Engineering, Medical Image Processing and Visualization. Linköping University, Sweden.
    Moreno, Rodrigo
    KTH, School of Technology and Health (STH), Medical Engineering, Medical Image Processing and Visualization.
    Granulometry-based trabecular bone segmentation2017In: 20th Scandinavian Conference on Image Analysis, SCIA 2017, Springer, 2017, Vol. 10270, p. 100-108Conference paper (Refereed)
    Abstract [en]

    The accuracy of the analyses for studying the three dimensional trabecular bone microstructure rely on the quality of the segmentation between trabecular bone and bone marrow. Such segmentation is challenging for images from computed tomography modalities that can be used in vivo due to their low contrast and resolution. For this purpose, we propose in this paper a granulometry-based segmentation method. In a first step, the trabecular thickness is estimated by using the granulometry in gray scale, which is generated by applying the opening morphological operation with ball-shaped structuring elements of different diameters. This process mimics the traditional sphere-fitting method used for estimating trabecular thickness in segmented images. The residual obtained after computing the granulometry is compared to the original gray scale value in order to obtain a measurement of how likely a voxel belongs to trabecular bone. A threshold is applied to obtain the final segmentation. Six histomorphometric parameters were computed on 14 segmented bone specimens imaged with cone-beam computed tomography (CBCT), considering micro-computed tomography (micro-CT) as the ground truth. Otsu’s thresholding and Automated Region Growing (ARG) segmentation methods were used for comparison. For three parameters (Tb.N, Tb.Th and BV/TV), the proposed segmentation algorithm yielded the highest correlations with micro-CT, while for the remaining three (Tb.Nd, Tb.Tm and Tb.Sp), its performance was comparable to ARG. The method also yielded the strongest average correlation (0.89). When Tb.Th was computed directly from the gray scale images, the correlation was superior to the binary-based methods. The results suggest that the proposed algorithm can be used for studying trabecular bone in vivo through CBCT.

  • 32. Cinti, M. N.
    et al.
    Scafe, R.
    Bennati, Paolo
    KTH, School of Technology and Health (STH), Medical Engineering.
    Lo Meo, S.
    Frantellizzi, V.
    Pellegrini, R.
    De Vincentis, G.
    Sacco, D.
    Fabbri, A.
    Pani, R.
    Innovative LuYAP:Ce array for PET imaging2017In: Journal of Instrumentation, ISSN 1748-0221, E-ISSN 1748-0221, Vol. 12, no 3, article id C03069Article in journal (Refereed)
    Abstract [en]

    We present an imaging characterization of a 10 x 10 LuYAP array (2 x 2 x 10 mm3 pixels) with an innovative dielectric coating insulation (0.015 mm thick), in view of its possible use in a gamma camera for imaging positron emission tomography (PET) or in similar applications, e.g. as γ-prompt detector in hadron therapy. The particular assembly of this array was realized in order to obtain a packing fraction of 98%, improving detection efficiency and light collection. For imaging purpose, the array has been coupled with a selected Hamamatsu H10966-100 Multi Anode Photomultiplier read out by a customized 64 independent channels electronics. This tube presents a superbialkali photocathode with 38% of quantum efficiency, permitting to enhance energy resolution and consequently image quality. A pixel identification of about 0.5 mm at 662 keV was obtained, highlighting the potentiality of this detector in PET applications.

  • 33.
    Corné, Josefine
    et al.
    KTH, School of Technology and Health (STH).
    Ullvin, Amanda
    KTH, School of Technology and Health (STH).
    Prediktiv analys i vården: Hur kan maskininlärningstekniker användas för att prognostisera vårdflöden?2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    This project was performed in cooperation with Siemens Healthineers. The project aimed to investigate possibilities to forecast healthcare processes by investigating how big data and machine learning can be used for predictive analytics. The project consisted of two separate case studies. Based on data from previous MRI examinations the aim was to investigate if it is possible to predict duration of MRI examinations and identify potential no show patients. The case studies were performed with the programming language R and three machine learning methods were used to develop predictive models for each case study. The results from the case studies indicate that with a greater amount of data of better quality it would be possible to predict duration of MRI examinations and potential no show patients. The conclusion is that these types of predictive models can be used to forecast healthcare processes. This could contribute to increased effectivity and reduced waiting time in healthcare.

  • 34.
    Cruz Nunez, Paulo
    et al.
    KTH, School of Technology and Health (STH).
    Sorcini, Emil
    Utvekling av ett nytt roterande fantom: Vid extrakorporeal strålbehandling av lokalt avancerat sarkom i skelett2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Extrakorporeal strålbehandling av skelettsarkom är en variant av strålbehandling där en del av en patients skelett opereras ut från kroppen. Skelettsegmentet transporteras sedan vidare till ett annat behandlingsrum där den bestrålas inuti ett fantom m.h.a. en linjäraccelerator. Detta sker medan patienten är nedsövd. Efter bestrålningen kan skelettsegmentet opereras tillbaka in till patienten. På Karolinska Universitetssjukhuset i Solna görs denna strålbehandling med en metod som kräver relativt lång bestrålningstid. Detta beror på fantomets kubiska form. Ju närmare ett fantom är strålkällan desto mindre stråltid behövs. Vid det kubiska fantomet används två strålfält, ett framför och ett bakom fantomet. Det här betyder att ifall fantomets position förs närmare strålkällan, så måste den föras tillbaka lika mycket åt andra hållet efter första strålfältet. Detta gör att det blir opraktiskt samt att man inte vinner någon tid. Målet med detta projekt var att skapa ett fantom som kan förflyttas så nära strålkällan som möjligt för att minska så mycket stråltid som möjligt. Detta kommer i sin tur minska den totala behandlingstiden. Genom att skapa ett roterande cylinderformat fantom som inte är riktningsberoende, så kunde fantomet förflyttas 25 cm närmare (från 95 cm till 70 cm), jämfört med det kubiska fantomets avstånd till strålkällan. Cylinderfantomet var gjord av akrylplast och en rotationsanordning konstruerades för att rotera fantomet. Vinkelhastigheten på rotationsanordningen sattes till 15 varv/minut. Det kubiska och cylindriska fantomet jämfördes genom simuleringar. Det visade sig att bägges stråldosfördelning var likvärdiga. Bestrålningstiden kunde förkortas ner från 640 sekunder till 340 sekunder utan att negativt påverka dosfördelningen jämfört med tidigare metod.

  • 35. Cui, Zhao Ying
    et al.
    Famaey, Nele
    Depreitere, Bart
    Ivens, Jan
    Kleiven, Svein
    KTH, School of Technology and Health (STH), Medical Engineering, Neuronic Engineering.
    Vander Sloten, Jos
    On the assessment of bridging vein rupture associated acute subdural hematoma through finite element analysis2017In: Computer Methods in Biomechanics and Biomedical Engineering, ISSN 1025-5842, E-ISSN 1476-8259, Vol. 20, no 5, p. 530-539Article in journal (Refereed)
    Abstract [en]

    Acute subdural hematoma (ASDH) is a type of intracranial haemorrhage following head impact, with high mortality rates. Bridging vein (BV) rupture is a major cause of ASDH, which is why a biofidelic representation of BVs in finite element (FE) head models is essential for the successful prediction of ASDH. We investigated the mechanical behavior of BVs in the KTH FE head model. First, a sensitivity study quantified the effect of loading conditions and mechanical properties on BV strain. It was found that the peak rotational velocity and acceleration and pulse duration have a pronounced effect on the BV strains. Both Young's modulus and diameter are also negatively correlated with the BV strains. A normalized multiple linear regression model using Young's modulus, outer diameter and peak rotational velocity to predict the BV strain yields an adjusted -value of 0.81. Secondly, cadaver head impact experiments were simulated with varying sets of mechanical properties, upon which the amount of successful BV rupture predictions was evaluated. The success rate fluctuated between 67 and 75%. To further increase the predictive capability of FE head models w.r.t. BV rupture, future work should be directed towards improvement of the BV representation, both geometrically and mechanically.

  • 36.
    Danell Lindström, Emma
    et al.
    KTH, School of Technology and Health (STH).
    El-Ghorayeb, Graziella
    KTH, School of Technology and Health (STH).
    Evaluation of Impact Loading Rates Dependency on Prescale Pressure Film2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Migraine is the third most common medical condition in the world. Xiaogai Li have a hypothesis that implies that a hit to the head when first sensing the aura symptoms will stop the migraine attack. An investigation was made to ensure that the blow does not cause a head injury. The prescale pressure film from Fujifilm is a sensor that measures pressure and the pressure distribution. It is supplied with charts to determine the pressure when purchased. The pressure film was used to measure the reached loading impact from the blow. The new chart for the pressure film would in that case be used to create simulations to study the potential brain damage a hit to the head can result in.

    This paper examines whether loading rates has an influence on a prescale pressure film from Fujifilm, in order to create new pressure charts if such dependency is found. The testing was made with the help of a loading machine where the desired force could be set. The results showed a lower color density in the test results when comparing with the provided charts. The reason for this is unknown, although it could be a consequence of the environmental conditions that the pressure film was held in. The conclusion made by studying the results was that no loading rate dependency exists.

  • 37. Daudi, Morice
    et al.
    Baalsrud Hauge, Jannicke
    KTH, School of Technology and Health (STH), Health Systems Engineering.
    Thoben, Klaus-Dieter
    A Trust Framework for Agents' Interactions in Collaborative Logistics2017In: DYNAMICS IN LOGISTICS, LDIC 2016, Springer, 2017, p. 53-63Conference paper (Refereed)
    Abstract [en]

    Trust is an essential factor for successful resource sharing in logistics. To build and sustain trust among collaborating partners in logistics requires, amongst others, conceptualizing on various aspects constituting underlying mistrusts. The conception is achieved by setting up a framework describing trust-based collaborative interactions of these partnering entities, referred to as agents. This research establishes a trust framework addressing agents' trustworthy interactions and thus aims at overcoming a knowledge gap identified in the literature. The framework depicts trust-based interactions concentrating to sharing of vehicle capacities. The trust framework is conceived on a foundation of theoretical body of knowledge in the literature. It engages knowledge on collaborative networks, logistics and transportation, agent behavior as well as trust. This research contributes by identifying key agents together with their roles, characteristics, tasks, information exchange as well as perceptions; all of which linked to agent trust. The framework is reusable in many ways, including formal conception of models aspiring to empirically investigate trust amongst agents sharing logistics resources. It also provides more understanding to practitioners, especially on issues relating to compromising differences resulting from agent's perspectives.

  • 38.
    Dellve, Lotta
    et al.
    KTH, School of Technology and Health (STH), Health Systems Engineering, Ergonomics.
    Eriksson, Andrea
    KTH, School of Technology and Health (STH), Health Systems Engineering, Ergonomics.
    Health-Promoting Managerial Work: A Theoretical Framework for a Leadership Program that Supports Knowledge and Capability to Craft Sustainable Work Practices in Daily Practice and During Organizational Change2017In: Societies, ISSN 1090-9389, E-ISSN 2075-4698, Vol. 7, no 2, article id 12Article in journal (Refereed)
    Abstract [en]

    The aim of this article is to describe a theoretical framework, i.e., theoretical underpinnings and pedagogical principles, for leadership programs that support managers' evidence-based knowledge of health-promoting psychosocial work conditions, as well as their capability to apply, adapt, and craft sustainable managerial work practices. First, the theoretical framing is introduced, i.e., a system theory that integrates key work conditions with a practical perspective on managerial work and organization. Second, pedagogical principles and measures for leaders' training in integrated handling across system levels are described. Last, we present summarized results from an intervention study applying the theoretical framework and pedagogical principles. The complexity of interactions among different factors in a work system, and the variety in possible implementation approaches, presents challenges for the capability of managers to craft sustainable and health-promoting conditions, as well as the evaluation of the program components. Nevertheless, the evaluation reveals the strength of the program, in providing holistic and context-sensitive approaches for how to train and apply an integrative approach for improving the work environment.

  • 39.
    Eiken, Ola
    et al.
    KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Environmental Physiology.
    Keramidas, Michail E.
    KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Environmental Physiology.
    Taylor, Nigel A S
    Grönkvist, Mikael
    KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Environmental Physiology.
    Intraocular pressure and cerebral oxygenation during prolonged headward acceleration2017In: European Journal of Applied Physiology, ISSN 1439-6319, E-ISSN 1439-6327, Vol. 117, no 1, p. 61-72Article in journal (Refereed)
    Abstract [en]

    Supra-tolerance head-to-foot directed gravitoinertial load (+Gz) typically induces a sequence of symptoms/signs, including loss of: peripheral vision-central vision-consciousness. The risk of unconsciousness is greater when anti-G-garment failure occurs after prolonged rather than brief exposures, presumably because, in the former condition, mental signs are not consistently preceded by impaired vision. The aims were to investigate if prolonged exposure to moderately elevated +Gz reduces intraocular pressure (IOP; i.e., improves provisions for retinal perfusion), or the cerebral anoxia reserve. Subjects were exposed to 4-min +Gz plateaux either at 2 and 3 G (n = 10), or at 4 and 5 G (n = 12). Measurements included eye-level mean arterial pressure (MAP), oxygenation of the cerebral frontal cortex, and at 2 and 3 G, IOP. IOP was similar at 1 (14.1 +/- 1.6 mmHg), 2 (14.0 +/- 1.6 mmHg), and 3 G (14.0 +/- 1.6 mmHg). During the G exposures, MAP exhibited an initial prompt drop followed by a partial recovery, end-exposure values being reduced by ae<currency>30 mmHg. Cerebral oxygenation showed a similar initial drop, but without recovery, and was followed by either a plateau or a further slight decrement to a minimum of about -14 mu M. Gz loading did not affect IOP. That cerebral oxygenation remained suppressed throughout these G exposures, despite a concomitant partial recovery of MAP, suggests that the increased risk of unconsciousness upon G-garment failure after prolonged +Gz exposure is due to reduced cerebral anoxia reserve.

  • 40.
    Eklund, Jörgen
    KTH, School of Technology and Health (STH), Health Systems Engineering, Ergonomics. Helix, LiU.
    Keynote: The hidden relationship between ergonomics and quality2017In: 48th Annual Conference of the Association of Canadian Ergonomists, 2017Conference paper (Refereed)
    Abstract [en]

    SUMMATIVE STATEMENT 

    There is strong evidence that insufficient ergonomics cause quality deficiencies in production. Despite this, it has not yet been accepted that ergonomics is an important production factor. Reasons for this situation and possible actions are discussed.

     

    PROBLEM STATEMENT 

    The scientific literature reports many examples of relationships between ergonomics and quality. However, this knowledge has not been sufficiently systematized for ergonomics to become generally accepted as a production factor.

     

    RESEARCH OBJECTIVE

    The objective of this paper is to summarize different perspectives on the relationship between ergonomics and quality, and to discuss the formation of this knowledge on a generalized level.

     

    RESULTS

    There is a large number of studies and reviews that have identified strong relationships between the quality performance of individuals and different ergonomics aspects such as light, noise, vibration, ventilation, climate, cognition and physical ergonomics. Further, there are also a large number of studies that have identified a relationship between ergonomics and quality output for the organization in different production settings. There are also examples when causality has been shown. All together, this evidence point to that good ergonomics is a precondition for quality performance, in other words an important production factor.

     

    DISCUSSION

    The strong relationship between ergonomics and quality might be accepted within the ergonomics discipline, but not as a production factor and not in working life. TQM and Lean address quality and some aspects of work design as important production factors. There are many reasons why it is not generally recognized that ergonomics is an important production factor. Some of them might be that the research literature is not explicit on this point, the ergonomics knowledge is not spread to the production discipline, and that ergonomics is seen an additional luxury for the employees, provided when the economy of the organization is sufficiently strong. Still another reason might be that there are also examples of how ergonomics improvements can be shown to be unprofitable for the organization.

     

    CONCLUSIONS  

    A large number of research studies show strong evidence that insufficient ergonomics cause quality deficiencies in production, both on an individual and on an organizational level, confirming that ergonomics is a production factor. It is a problem that this knowledge is not formed, disseminated and accepted by production engineers and managers.

     

  • 41.
    Eklund, Jörgen
    KTH, School of Technology and Health (STH), Health Systems Engineering, Ergonomics. Helix, LiU.
    Lean in retail – implementation in stores2017In: / [ed] Anna-Lisa Osvalder, Mikael Blomé, Hajnalka Bodnar, Lund, 2017Conference paper (Refereed)
    Abstract [en]

    Background and purpose

    Lean has been implemented to varying degrees in different organizations and in different branches. Mass-producing manufacturing industries were early in this respect, and later followed by e.g. healthcare, authorities and municipalities. Presently, some stores are implementing Lean-inspired working methods. The purpose of this paper is to identify different ways of working with and implementing Lean in stores.

     

    Methods

    The methods used were case studies in 9 stores. The stores were visited and data were collected through observation of working methods and artefacts in the stores, interviews were conducted with employees and managers, and a questionnaire was answered by a sample of those working in the stores. Finally, documents were collected and photographs were taken.

     

    Results

    A few stores worked according to some the principles of Lean, and other stores had implemented some of the Lean tools. Other stores had statements of the values for the organization on display. Continuous improvement and 5S were two commonly used tools. Visualisation by using whiteboards and KPIs were also applied in several stores, and daily meetings between the store manager and the employees were also taking place in a few stores. Waste reduction has been used for a long time in stores handling fresh food, as well as substantial work in order to improve the logistics. These are aspects that Lean include, but were present in the stores before Lean was introduced.

     

    Discussion with practical implications

    Few examples of a long-term Lean tradition exist. Disseminating good examples that are also good for the work environment of the employees could support a more holistic way of working with Lean and improve working conditions in the future.

     

    Conclusions

    The use of Lean in stores is under development, and several stores have started to introduce Lean-inspired working methods, such as Continuous improvement, 5S, customer orientation, visualization, daily whiteboard meetings and waste reduction.

     

  • 42.
    Ekman, Jonas
    KTH, School of Technology and Health (STH), Medical Engineering, Computer and Electronic Engineering.
    Evaluation of HCI models to control a network system through a graphical user interface2017Independent thesis Basic level (university diploma), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    SAAB has a project under development for a network system with connected nodes, where the nodes are both information consumer and producer of different communication types. A node is an equipment or an object that are used by the army e.g. it can be a soldier, military hospital or an UAV. The nodes function as a part of a mission e.g. a mission can be Defend Gotland. The aim of this project is that the user will rank different missions from the one with the highest priority to the lowest. This will affect the network in a way that the communication between the nodes at the mission with the highest rank will be prioritised over the communication between the underlying missions. A user can via the GUI rank the missions, and then set the associated settings for them. Via the GUI the user should be able to work at three different levels. The first is to plan upcoming missions. The second one is in real time see if the system delivers the desired conditions. The last one is to simulate if the system can deliver the desired conditions.

    This thesis investigated various HCI models that could be used to create a GUI, to reduce the risk of a user configuring the system incorrectly. The study showed that there are no HCI models that take account for misconfigurations, and therefore a new model was created. The new model was used and evaluated by creating a prototype of a GUI for SAAB’s project and was tested on a potential user. The test showed that the new model reduced the risk of misconfigurations.

  • 43.
    Eliasson, Kristina
    KTH, School of Technology and Health (STH), Health Systems Engineering, Ergonomics.
    Occupational health services in the prevention of musculoskeletal disorders: Processes, tools and organizational aspects2017Licentiate thesis, comprehensive summary (Other academic)
    Abstract [en]

    Work-related musculoskeletal disorders are associated with high costs and it is essential to prevent them. Occupational Health Services(OHS) provide expert services regarding work environment, health and rehabilitation of work related disorders. Risk assessments of the work environment can be an initial step for preventive measures, and ergonomists can be assigned by clients to assess exposures in the work environment. For such assignments different tools can be used. The aim of this thesis was to explore prerequisites, processes and practices of OHS consultants in Sweden within the domain of primary prevention of work-related musculoskeletal disorders. This was explored through the work of ergonomists in their role of assessing ergonomics risks. The research methodology was both quantitative and qualitative. Data collection includes a web questionnaire, semi-structured interviews and inter- and intra-observer reliability tests. The results shows that ergonomics risk assessments were most commonly initiated reactively and a systematic work methodology for the risk assessment process was often lacking. Swedish ergonomists used only a few standardized tools for risk assessment. The Ergonomics provision from the Swedish Work Environment Authority, AFS-98, was widely used, but other observation-based tools were used far less often. Ergonomics risks were often assessed solely by means of observation, based on ergonomists’ knowledge and experience. The results also pointed to that that the reliability was not acceptable when risk assessment was performed without any standardized tool. Furthermore, the results point to that support from the OHS organizations is an important prerequisite for ergonomists to work with primary prevention. Further, opportunities for specialization within a specific industry sector seem to facilitate ergonomic interventions. It is also important to have close relationships with clients and to make them aware about ergonomists competence. Conclusively, this thesis identifies a numbers of areas in which OHS must develop to improve primary preventive services regarding work environment.

  • 44.
    Eliasson, Kristina
    et al.
    KTH, School of Technology and Health (STH), Health Systems Engineering, Ergonomics.
    Palm, P.
    Nyman, Teresia
    KTH, School of Technology and Health (STH), Health Systems Engineering, Ergonomics.
    Forsman, M.
    Inter - and intra - observer reliability of risk assessment of repetitive work without an explicit method2017In: Applied Ergonomics, ISSN 0003-6870, E-ISSN 1872-9126, Vol. 62, p. 1-8Article in journal (Refereed)
    Abstract [en]

    A common way to conduct practical risk assessments is to observe a job and report the observed long term risks for musculoskeletal disorders. The aim of this study was to evaluate the inter- and intra-observer reliability of ergonomists' risk assessments without the support of an explicit risk assessment method. Twenty-one experienced ergonomists assessed the risk level (low, moderate, high risk) of eight upper body regions, as well as the global risk of 10 video recorded work tasks. Intra-observer reliability was assessed by having nine of the ergonomists repeat the procedure at least three weeks after the first assessment. The ergonomists made their risk assessment based on his/her experience and knowledge. The statistical parameters of reliability included proportional agreement, kappa, linearly weighted kappa, intraclass correlation and Kendall's coefficient of concordance. The average inter-observer proportional agreement of the global risk was 53% and the corresponding weighted kappa was 0.32, indicating fair reliability. The intra-observer agreement was 61% and 0.41. This study indicates that risk assessments of the upper body, without the use of an explicit observational method, have non-acceptable reliability. It is therefore recommended to use systematic risk assessment methods to a higher degree.

  • 45.
    Emilsson, Linnea
    et al.
    KTH, School of Technology and Health (STH).
    Tarasov, Yevgen
    KTH, School of Technology and Health (STH).
    Minimizing the Number of Electrodes for Epileptic Seizures Prediction2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Epilepsy is a neurological disorder affecting 1-2 % of the population in the world. People diagnosed with epilepsy are put at high risk of getting injured due to the unpredictable seizures caused by the disorder. Electroencephalography (EEG) in combination with machine learning can be used for prediction of an epileptic seizure. Therefore, a portable prediction device is of great interest with high emphasis for it to be user-friendly. One way to achieve this is by minimizing the number of electrodes placed on the scalp. This study examines the number of electrodes that provide sufficient information for prediction of a seizure. The highest prediction accuracy of 91 %, 97 % sensitivity and 85 % specificity was achieved with as few as 16 electrodes. Due to the limitation of the intracranial EEG recordings further testing must be performed on scalp EEG recordings to provide valid results.

  • 46.
    Emrani, Zahra
    et al.
    Medical Image and Signal Processing Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
    Karbalaie, Abdolamir
    KTH, School of Technology and Health (STH), Health Systems Engineering.
    Fatemi, Alimohammad
    Department of Rheumatology, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
    Etehad Tavakol, Mahnaz
    Medical Image and Signal Processing Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
    Erlandsson, Björn-Erik
    KTH, School of Technology and Health (STH), Health Systems Engineering.
    Capillary density: An important parameter in nailfold capillaroscopy2017In: Microvascular Research, ISSN 0026-2862, E-ISSN 1095-9319, Vol. 109, p. 7-18Article in journal (Refereed)
    Abstract [en]

    Nailfold capillaroscopy is one of the various noninvasive bioengineering methods used to investigate skin microcirculation. It is an effective examination for assessing microvascular changes in the peripheral circulation; hence it has a significant role for the diagnosis of Systemic sclerosis with the classic changes of giant capillaries as well as the decline in capillary density with capillary dropout. The decline in capillary density is one of microangiopathic features existing in connective tissue disease. It is detectable with nailfold capillaroscopy. This parameter is assessed by applying quantitative measurement. In this article, we reviewed a common method for calculating the capillary density and the relation between the number of capillaries as well as the existence of digital ulcers, pulmonary arterial hypertension, autoantibodies, scleroderma patterns and different scoring system.

  • 47.
    Eriksson, Andrea
    et al.
    KTH, School of Technology and Health (STH), Health Systems Engineering, Ergonomics.
    Orvik, Arne
    Strandmark, Margaretha
    Nordsteien, Anita
    Torp, Steffen
    Management and Leadership Approaches to Health Promotion and Sustainable Workplaces: A Scoping Review2017In: Societies, ISSN 1090-9389, E-ISSN 2075-4698, Vol. 7, no 2, article id 14Article, review/survey (Refereed)
    Abstract [en]

    Whole-system approaches linking workplace health promotion to the development of a sustainable working life have been advocated. The aim of this scoping review was to map out if and how whole-system approaches to workplace health promotion with a focus on management, leadership, and economic efficiency have been used in Nordic health promotion research. In addition, we wanted to investigate, in depth, if and how management and/or leadership approaches related to sustainable workplaces are addressed. Eighty-three articles were included in an analysis of the studies' aims and content, research design, and country. For a further in-depth qualitative content analysis we excluded 63 articles in which management and/or leadership were only one of several factors studied. In the in-depth analysis of the 20 remaining studies, four main categories connected to sustainable workplaces emerged: studies including a whole system understanding; studies examining success factors for the implementation of workplace health promotion; studies using sustainability for framing the study; and studies highlighting health risks with an explicit economic focus. Aspects of sustainability were, in most articles, only included for framing the importance of the studies, and only few studies addressed aspects of sustainable workplaces from the perspective of a whole-system approach. Implications from this scoping review are that future Nordic workplace health promotion research needs to integrate health promotion and economic efficiency to a greater extent, in order to contribute to societal effectiveness and sustainability.

  • 48. Ermund, Anna
    et al.
    Meiss, Lauren N.
    Rodriguez-Pineiro, Ana M.
    Baehr, Andrea
    Nilsson, Harriet E.
    KTH, School of Technology and Health (STH), Medical Engineering. Department of Medical Biochemistry, University of Gothenburg, SE-405 30 Gothenburg, Sweden; Department of Biosciences and Nutrition, Karolinska Institutet, and School of Technology and Health, KTH Royal Institute of Technology, Novum, SE-141 57 Huddinge, Sweden.
    Trillo-Muyo, Sergio
    Ridley, Caroline
    Thornton, David J.
    Wine, Jeffrey J.
    Hebert, Hans
    KTH, School of Technology and Health (STH), Medical Engineering, Structural Biotechnology. Department of Biosciences and Nutrition, Karolinska Institutet, and School of Technology and Health, KTH Royal Institute of Technology, Novum, SE-141 57 Huddinge, Sweden.
    Klymiuk, Nikolai
    Hansson, Gunnar C.
    The normal trachea is cleaned by MUC5B mucin bundles from the submucosal glands coated with the MUC5AC mucin2017In: Biochemical and Biophysical Research Communications - BBRC, ISSN 0006-291X, E-ISSN 1090-2104, Vol. 492, no 3, p. 331-337Article in journal (Refereed)
    Abstract [en]

    To understand the mucociliary clearance system, mucins were visualized by light, confocal and electron microscopy, and mucus was stained by Alcian blue and tracked by video microscopy on tracheal explants of newborn piglets. We observed long linear mucus bundles that appeared at the submucosal gland openings and were transported cephalically. The mucus bundles were shown by mass spectrometry and immunostaining to have a core made of MUC5B mucin and were coated with MUC5AC mucin produced by surface goblet cells. The transport speed of the bundles was slower than the airway surface liquid flow. We suggest that the goblet cell MUC5AC mucin anchors the mucus bundles and thus controls their transport. Normal clearance of the respiratory tree of pigs and humans, both rich in submucosal glands, is performed by thick and long mucus bundles. 

  • 49.
    Ernmark, Niklas
    KTH, School of Technology and Health (STH), Medical Engineering, Computer and Electronic Engineering.
    Utveckling av en CAN-adapter i ett sensorsystem för övervakning av däcktryck.: Development of a CAN-adapter in a sensor system for tire pressure monitoring.2017Independent thesis Basic level (university diploma), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    This report describes a degree project at the Royal Institute of Technology. The purpose was to create a unique system solution in which a CAN adapter card (Controller Area Network) was to be integrated with an air pressure monitoring system for heavy duty vehicles. The goal was to present measurement values ​​from valve sensors on a personal computer. The air pressure monitoring system is called J1939 - TPMS and is a finished product. J1939 - TPMS sends CAN-frames to a CAN-bus in J1939 format. These frames are to be read by the adapter card and presented on a terminal program on a personal computer. The job has been to investigate how the J1939 - TPMS system works in detail. The role of the J1939 protocol and its relationship with CAN has been clarified. Also, a detailed description of how J1939 frames are interpreted and how the measuring data TPMS is decoded is done. Principles for how a CAN node works has been clarified. Based on this, a CAN adapter card has been designed. The design has included component selection, design of electronics schema, design of computer cards and development of embedded software. The result was a ready-to-use CAN adapter card tested with J1939-TPMS. Requirements for the project were met. However, more work with the card will be needed to make it a finished product. The work was carried out at Motion Control in Västerås AB in cooperation with Transeco Däckservice (Transeco Tire Service).

  • 50.
    Ezzeddine, Kassem
    et al.
    KTH, School of Technology and Health (STH), Medical Engineering, Computer and Electronic Engineering.
    Oskarsson, Robert
    KTH, School of Technology and Health (STH), Medical Engineering, Computer and Electronic Engineering.
    Analys av kondensatorbatteriers tillkopplingsfenomen: Undersökning av de kopplingsfenomen som uppstår vid tillkoppling av kondensatorbatterier och deras påverkan på närliggande komponenter2017Independent thesis Basic level (university diploma), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Many electrical devices need reactive power to operate. Transmission of reactive power occupies a proportion of the available capacity in the power system and therefore capacitor banks are used near to the end user to generate reactive power. Thus, the reactive effect is generated and consumed in a separate part of the power system. Capacitor banks switching causes transients which may damage the surrounding components.

    Based on the real substation Stallbacka in Trollhättan, this study has analysed capacitor banks switching transients within the medium voltage level. The analysis has covered the size of these transients according to different conditions and scenarios. The result showed that the transients in this case never reached serious levels, thus there was no impact on the components. It is not clear whether the transients affect the power quality because there are no defined limits. 

    A calculation tool to the predicted transients was supposed to be created in the process. This calculation tool was never completed due to the unmanageable solution that was obtained.

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