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  • 1.
    Abtahi, Farhad
    et al.
    KTH, School of Technology and Health (STH), Medical Engineering, Medical sensors, signals and systems.
    Lu, Ke
    KTH, School of Technology and Health (STH), Medical Engineering, Medical sensors, signals and systems.
    Dizon, M
    KTH, School of Technology and Health (STH), Medical Engineering, Medical sensors, signals and systems.
    Johansson, M
    KTH-School of Technology and Health.
    Seoane, Fernando
    KTH, School of Technology and Health (STH), Medical Engineering, Medical sensors, signals and systems. Högskolan i Borås.
    Lindecrantz, Kaj
    KTH, School of Technology and Health (STH), Medical Engineering, Computer and Electronic Engineering. Högskolan i Borås, Akademin för vård, arbetsliv och välfärd.
    Evaluating Atrial Fibrillation Detection Algorithm based on Heart Rate Variability analysis2015In: Medicinteknikdagarna, Uppsala: Svensk förening för medicinsk teknik och fysik , 2015Conference paper (Refereed)
  • 2. Capese, Sabrina
    et al.
    Chiessi, E.
    Cavalli, R.
    Giustetto, P.
    Grishenkov, Dmitry
    KTH, School of Technology and Health (STH), Medical Engineering, Medical Imaging.
    Paradossi, Gaio
    Diapartimento di Chimica, Università di Roma Tor Vergata.
    A general strategy for the obtainment of biodegradable polymer shelled microbubbles as theranostic device2013Conference paper (Refereed)
    Abstract [en]

    Introduction

    Fabrication of multifunctional ultrasound contrast agents (UCAs) has been addressed by many research groups.1,2 Recently a poly(vinyl alcohol) shelled microbubble 3 has shown a remarkable chemical and physical stability and versatility for the surface functionalization, leading to a platform for multimodality imaging (ultrasounds, magnetic resonance, single photon emission computer tomography) and targeting inflammation and tumours4. In this contribution we present a new strategy for the synthesis of UCAs precursors in the form of vesicles with a biodegradable crosslinked polymer shell.

    Methods

    Deposition of methacryloyl-derivative of hydrophilic and biodegradable polymers as dextran (DexMA50) or hyaluronic acid (HAMA30) on a lipid vesicle with a liquid perfluoropentane core, 5,6 followed by a photopolymerization of the methacrylate moiety allows the obtainment of polymer shelled vesicles.

    Results

    Lipid shelled vesicles with a perfluorocarbon (PFC) core (Figure 1a) undergo an acoustic droplet vaporization (ADV),7 upon ultrasounds (US) irradiation, transforming such particles into ultrasound effective microbubbles (Fig 1b). The process is reversible as the US are switched off (Fig 1c). In the “microbubble” state, i.e. during US irradiation, the system is echogenic at low mechanical index, allowing their use as UCAs. In this contribution we show that additional functions can be implemented into the microbubbles. For example, we demonstrated the possibility to obtain shells with a thermoreversible behaviour.

    Conclusions

    This new class of polymer shelled vesicles/microbubbles entails features desired in a potential theranostic microdevice.

  • 3. Debevec, T
    et al.
    Amon, M
    Keramidas, Michail E.
    KTH, School of Technology and Health (STH), Environmental Physiology (Closed 20130701).
    Kounalakis, S.N.
    Mekjavic, I.B.
    Hematological responses to two different intermittent hypoxic training regimens2009Conference paper (Refereed)
    Abstract [en]

    "Hypoxic training has been reported to enhance athletes’ altitude and sea-level performance by augmenting oxygen carrying capacity of the blood, as a consequence of increases in hematocrit and hemoglobin concentrations. However the effect of intermittent hypoxic training on hematological responses remains unresolved."

    This study investigated the effect of two intermittent hypoxic training regimens on the response of hematological indices. Healthy male Ss (N = 27) were equally assigned to a control group, a live low-train high (LL-TH) group, or a intermittent hypoxic exposure group. Ss performed a one-hour submaximal endurance exercise on a cycle ergometer, five days per week for four weeks, at an intensity corresponding to 50% of normoxic peak power output for the control and intermittent hypoxic exposure groups, and to 50% of hypoxic peak power output for the LL-TH group. Thus, all groups trained at the same relative work rate. The absolute work rate during training was 18-20 W lower for the LL-TH group compared to the other two groups. All groups lived at an altitude of ~300 m above sea level. The control and intermittent hypoxic exposure groups also trained at this altitude, whereas the LL-TH group trained in a hypoxic chamber, breathing a hypoxic mixture (FIO2=12%). In addition to the daily exercise training, the intermittent hypoxic exposure group also inspired a hypoxic gas mixture at rest, and prior to the cycle ergometry. The intermittent hypoxic training comprised breathing a hypoxic mixture during seven phases. Each phase consisted of five minutes of breathing a hypoxic mixture, followed by three minutes of breathing a normoxic gas mixture. Prior to, during, at the end, and 10 days after the training period, blood samples were taken from all Ss in order to measure hemoglobin, hematocrit, erythrocytes, ferritin, and transferrin concentrations.

    No significant differences were observed between groups in any measured hematological variables. Similarly, no significant differences were found within groups at the different testing periods.

    Implication. Although it has been reported that both LL-TH and intermittent hypoxic exposure protocols provide hematological benefits, that was not confirmed by this study. The tested protocols did not induce any changes in the measured hematological variables; therefore no improvements of the oxygen carrying capacity of the blood should be expected following this type of hypoxic training.

  • 4.
    Gennser, Mikael
    et al.
    KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Environmental Physiology.
    Blogg, L
    Venous gas bubble load after trimix dives using electronic closed circuit rebreathers2014Conference paper (Refereed)
  • 5.
    Grönkvist, Mikael
    et al.
    KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Environmental Physiology.
    Ciuha, U
    Eiken, Ola
    KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Environmental Physiology.
    Mekjavic, I.B.
    The effect of ambient humidity on performance during simulated desert patrols2014Conference paper (Refereed)
  • 6.
    Ho, Johnson
    et al.
    KTH, School of Technology and Health (STH), Neuronic Engineering.
    Kleiven, Svein
    KTH, School of Technology and Health (STH), Neuronic Engineering.
    Investigation of the Dynamic Response Contribution of Vasculature in a 3D Finite Element Head Model2006Conference paper (Refereed)
  • 7. Jaki Mekjavic, P.
    et al.
    Lenassi, E.
    Eiken, Ola
    KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Environmental Physiology. KTH, School of Technology and Health (STH), Centres, Swedish Aerospace Physiology Centre, SAPC.
    Mekjavic, I.B.
    The effect of acute hypercapnia during hypoxic bedrest and confinement on the retina2014Conference paper (Refereed)
  • 8.
    Janerot Sjöberg, Birgitta
    et al.
    CLINTEC, Department of Medical Imaging and Technology, Karolinska Institute.
    Gonon, Adrian
    tutet (KI), Dept of Medicine.
    Grishenkov, Dmitry
    KTH, School of Technology and Health (STH), Medical Engineering, Medical Imaging. Karolinska Institutet (KI), CLINTEC – Division of Medical Imaging and Technology.
    In Search of the Optimal Ultrasound Heart Perfusion Imaging Platform2013Conference paper (Refereed)
  • 9.
    Keramidas, Michail E.
    et al.
    KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Environmental Physiology.
    Amon, M.
    Debevec, T.
    Simunic, B.
    Pisot, R.
    Di Prampero, PE
    Mekjavic, I.B.
    Endurance respiratory muscle training: Does it affect performance in normoxia and hypoxia?2007Conference paper (Refereed)
  • 10. Kounalakis, S.N.
    et al.
    Keramidas, Michail E.
    KTH, School of Technology and Health (STH), Environmental Physiology (Closed 20130701).
    Biolo, G.
    Di Prampero, P.E.
    Narici, M.
    Pisot, R
    Eiken, Ola
    Mekjavic, I.B.
    Thermoregulatory responses to cold water immersion following 35 days of horizontal bed-rest2007Conference paper (Refereed)
  • 11. McDonnell, A.C.
    et al.
    Golemis, A
    Eiken, Ola
    KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Environmental Physiology. KTH, School of Technology and Health (STH), Centres, Swedish Aerospace Physiology Centre, SAPC.
    Mekjavic, I.B.
    PlanHab: Comparison of the circadian rythm of proximal-distal temperature gradient observed during exposures to normobaric and hypobaric hypoxia2014Conference paper (Refereed)
  • 12. Mekjavic, I.B.
    et al.
    Ciuha, U
    Grönkvist, Mikael
    KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Environmental Physiology.
    Eiken, Ola
    KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Environmental Physiology.
    The physiological strain index does not predict heat exhaustion2014Conference paper (Refereed)
  • 13. Mekjavic, I.B.
    et al.
    Dolenc-Groselj, L
    Morrison, S.A.
    Mirnik, D
    Korsic, S
    Eiken, Ola
    KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Environmental Physiology. KTH, School of Technology and Health (STH), Centres, Swedish Aerospace Physiology Centre, SAPC.
    PlanHab: Sleep and respiration during 21-day hypoxic bedrest2014Conference paper (Refereed)
  • 14. Mekjavic, I.B.
    et al.
    McDonnel, A
    Eiken, Ola
    KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Environmental Physiology. KTH, School of Technology and Health (STH), Centres, Swedish Aerospace Physiology Centre, SAPC.
    PlanHab: Circadian rythm of proximal-distal temperature gradient during 21-day hypoxic bedrest2014Conference paper (Refereed)
  • 15. Mekjavic, I.B.
    et al.
    Pattyn, N
    Mairesse, O
    Cortoos, A
    Collet, G
    Fernandez, H.T.
    MacDonald-Nethercott, E
    Morrison, S.A.
    Dolenc-Groselj, L
    Eiken, Ola
    KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Environmental Physiology. KTH, School of Technology and Health (STH), Centres, Swedish Aerospace Physiology Centre, SAPC.
    Sleep and performance during the winter months in Antarctica2014Conference paper (Refereed)
  • 16. Purhonen, P
    et al.
    Thomsen, K
    Koeck, Philip J. B.
    Maunsbach, AB
    Hebert, Hans
    KTH, School of Technology and Health (STH), Structural Biotechnology.
    Three-dimensional structure of renal Na,K-ATPase as determined by cryo-electron microscopy2007Conference paper (Refereed)
  • 17. Ros, Axel
    et al.
    Shamoun, Sanny
    KTH, School of Technology and Health (STH), Health Systems Engineering, Systems Safety and Management.
    Cook, Richard
    KTH, School of Technology and Health (STH), Health Systems Engineering, Systems Safety and Management.
    A FRAM (Functional Resonance Analysis Method) analysis of labour-and-delivery: Locating risk in a complex system2014Conference paper (Refereed)
    Abstract [en]

    Although outcomes in labour-and-delivery are generally good, the danger of rare catastrophic events is always present. Two fetal deaths in the labour-and-delivery suite in Jönköping had been analysed with root cause analysis (RCA). Those RCA’s did not identify common causes and RCA-derived countermeasures seemed narrowly reactive and insufficiently robust. The variable, unpredictable workload and high stakes found in a labour-and-delivery suite creates critical dependencies, and vulnerabilities that vary over time. The potential for resonance etween these dependencies is a systemic problem that is missed by RCA. In general RCA  does not lead to a deeper understanding of how systems function and how systems usually  works to prevent catastrophic outcomes. RCA might therefore not work as a system improvement tool. The aim of this study was to explore if a FRAM analysis could give better nderstanding of circumstances important for patient safety in labour-and-delivery not evident from previous RCA’s.

  • 18. Salvadego, Desy
    et al.
    Keramidas, Michail E.
    KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Environmental Physiology.
    Kölegård, Roger
    KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Environmental Physiology.
    Mavelli, Irene
    Eiken, Ola
    KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Environmental Physiology.
    Mekjavic, Igor B.
    Grassi, Bruno
    Prolonged exposure to hypoxia and microgravity: effects on skeletal muscle oxidative metabolism2015Conference paper (Refereed)
  • 19.
    Sampaio, José
    KTH, School of Technology and Health (STH), Ergonomics (Closed 20130701).
    LIGHT URBAN DESIGN STRATEGIES: THE CITIES' USERS AND URBAN SENSES: A QUALITATIVE APPROACH TO OUTDOOR URBAN PUBLIC SPACE LIGHTING2011In: “Proceedings of the 27th Session of the CIE”  / [ed] CIE, Vienna: CIE Central Bureau. 1201-1207, 2011Conference paper (Refereed)
  • 20.
    Seoane, Fernando
    et al.
    KTH, School of Technology and Health (STH), Medical Engineering, Medical sensors, signals and systems. Högskolan i Borås, Akademin för vård, arbetsliv och välfärd.
    Soroudi, Azadeh
    Högskolan i Borås, Sverige.
    Abtahi, Farhad
    KTH, School of Technology and Health (STH), Medical Engineering.
    Lu, Ke
    KTH, School of Technology and Health (STH), Medical Engineering.
    Skrifvars, Mikael
    Högskolan i Borås, Sverige.
    Printed Electronics Enabling a Textile-friendly Interconnection between Wearable Measurement Instrumentation & Sensorized Garments2016Conference paper (Refereed)
  • 21. Stavrou, Nektarios
    et al.
    Keramidas, Michail E.
    KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Environmental Physiology.
    Kounalakis, Stylianos
    Eiken, Ola
    KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Environmental Physiology.
    Mekjavic, Igor
    Maximal exercise in hypoxia leads to a profounder negative emotional state2014Conference paper (Refereed)
  • 22.
    Szucs, Stefan
    et al.
    Göteborgs Universitet.
    Dellve, Lotta
    KTH, School of Technology and Health (STH), Health Systems Engineering, Ergonomics.
    Jutengren, Göran
    Högskolan Borås.
    Pathways of reorganization, leadership and long-term sickness absence due to mental diagnosis among local government public sector employees in Sweden 1998-20122014In: 7th European Public Health Conference, 19-22 November 2014, Glasgow, Scotland: Conference Programme, 2014Conference paper (Refereed)
    Abstract [en]

    The aim is to study local variation in long-term sickness absence due to mental diagnosis among local government public sector employees during a fifteen year period (1998-2012) and its relation to reported larger reorganizations of local government public services in the periods of 2000-2004, 2006-2008 and 2010-2012. Longitudinal cluster analysis of ecological data is performed on the incidence of 90 days or longer sickness absence including new disability pensions each year between 1998 and 2012, generating clusters of municipalities with lower and higher incidence of sickness absence across the period studied. Aggregate data from surveys performed in 2004, 2008 and 2012 with the leading political, administrative and union representatives in all of the 290 municipal level local governments in Sweden on organizational change are used in logistic regression analysis to elucidate whether there are significant effects of different types of organizational change and leadership during the reorganization on mental sickness rates across time. The analysis is performed with control for organizational complexity of larger cities (residential cities and those with over 50.000 inhabitants), population size generally, and municipality unemployment levels. The results indicate statistically significant effects of both organizational changes reported 2004, 2008 and 2012, as well as leadership reported in 2012, on top of the impact of large scale organizational complexity. Large scale organizational complexity, as well as general organizational change pressure and mandatory management of work place meetings all tend to increase the probability for long-term sickness absence due to mental diagnosis. In contrast, organizational change guided by specific characteristics with regard to implementation within an organizational field (social care in 2008), as well as specific leadership by targeted manager-employee communication, tends to significantly reduce long-term sickness absence. These findings suggest two alternative pathways of reducing mental stress leading to long-term sickness absence for local governments during large scale reorganization: implementation within an organizational field, and managerial work-place policies based on personalized leadership communication.

1 - 22 of 22
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