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  • 1.
    Alfredsson, Maria
    Linköping University, Department of Physics, Chemistry and Biology, Chemistry.
    Synthesis and Characterization of Acrylfentanyl Metabolites2017Independent thesis Basic level (degree of Bachelor), 10,5 credits / 16 HE creditsStudent thesis
    Abstract [en]

    Acrylfentanyl is a synthetic opioid that has been widely used in the last year. To help in the fight against synthetic drugs two potential metabolites of acrylfentanyl, one monohydroxy and one dihydroxy were synthesized. These metabolites will hopefully later be implemented in the analytical methods for metabolites of acrylfentanyl in urine by the Swedish National Board of Forensic Medicine.

    To have metabolites for analysis are very important as they are the main target in drug testing.

    The method used to synthesize the metabolites is a five-step synthesis with an additional 6th step for the dihydroxy metabolite. The methods used in the synthesis includes protection of amine with tert-butyloxycarbonyl, reductive amination with sodium triaceto boronhydride, alkylation and demethylation with boron tribromide. The methods used produced good results with high yields in nearly all steps.

  • 2.
    Dollevoet, Kim
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Organic Chemistry.
    C-H activation of indoles catalyzed by a ruthenium-complex: Synthesis of 2-3-hexene-1-(pyrimidin-2-yl)1H-indole2013Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 3.
    Fällman, Tove
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC.
    Capturing of the carbonyl oxide intermediate in ozonolysis using aldehydes and ketones2014Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 4.
    Goy, Michel
    et al.
    KTH, School of Chemical Science and Engineering (CHE).
    Jakobsson, Catharina
    KTH, School of Chemical Science and Engineering (CHE).
    Kartläggning av allergiframkallande hårfärgningsämnen i toningar i Stockholm2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    En vanlig källa till kontakallergiskt eksem är sensibiliserande (allergiframkallande) kemikalier som finns i hårfärger. Permanenta hårfärger innehåller kraftiga allergener, men det saknas kartläggande forskning på toningar. För att ta reda på vilka allergener som ingår i toningar behöver dagens utbud kartläggas. Detta projekt har skett i Stockholm och innehållet i sex olika märken har kartlagts. Toningar och permanenta hårfärger skiljer sig åt genom att permanenta hårfärger polymeriseras i håret genom oxidation med väteperoxid. Toningar innehåller kromofora ämnen som fäster i håret, antingen genom diffusion eller adsorption. Totalt kunde tio kromofora ämnen med kända sensibiliserande egenskaper hittas i toningarna varav en möjlig cancerogen. I varje produkt fanns i snitt 0,4–2,4, och som mest tre, kända sensibiliserande kromofora ämnen. Hårfärger utan sensibiliserande färgämnen kunde hittas i alla kulörer utom svart och brun. Även sensibiliserande parfymämnen och konserveringsmedel kunde påvisas. Eftersom det finns hårfärger i de flesta kulörer utan sensibiliserande färgämnen bör dessa ämnen fasas ut.

  • 5.
    Willén, Daniel
    Linköping University, Department of Physics, Chemistry and Biology, Organic Chemistry. Linköping University, The Institute of Technology.
    Synthesis of azidoethyl 3,4,6-tri-O-acetyl-α-D-mannopyranoside for future bioconjugation in PET studies2013Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Positron emission tomography is a powerful imaging method capable of diagnosing and studyingdiseases at atomic levels. The following thesis involves the synthesis of a 2 -deoxy-2 -[18F]uoro-D-glucose derivative able to participate in click chemisty conjugation. The synthesis involves six stepswith D-mannopyranose as starting material; regioselective acetylation and protection of the hydroxylgroup on C-2 of the monosaccharide, glycosylation with 2-azidoethanol, removal of the selectiveprotecting group and substitution of the hydroxyl group on C-2 with uorine. The potential toconjugate the glycoside to other biomolecules and obtain PET data might have uses in diagnosticaland medicinal chemistry.

  • 6.
    Zetterström, Susanna
    Linköping University, Department of Physics, Chemistry and Biology, Organic Chemistry. Linköping University, The Institute of Technology.
    Isolation and synthesis of curcumin2012Independent thesis Basic level (degree of Bachelor), 10,5 credits / 16 HE creditsStudent thesis
    Abstract [en]

    The aim of this thesis was to evaluate pre-existing methods for isolation and synthesis of curcumin. Two different isolation methods were used, where only the extraction step differs from each other. To obtain pure curcumin, column chromatography was needed to separate the compound from its analogues. As for the isolation the synthesis was also carried out by two different methods, the first in a conventional way and the second one by using irradiation of microwaves.

    The result of the experiments shows that by comparing the effectiveness and expense of the methods, the synthesis would probably be the easiest way of obtaining pure compound. Because of the more straightforward method, without cumbersome separation steps from the curcumin analogues, the synthesis was a faster way of obtaining the compound and gave more pure curcumin than the isolation procedures from turmeric.

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