Endre søk
Begrens søket
123 1 - 50 of 104
RefereraExporteraLink til resultatlisten
Permanent link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Treff pr side
  • 5
  • 10
  • 20
  • 50
  • 100
  • 250
Sortering
  • Standard (Relevans)
  • Forfatter A-Ø
  • Forfatter Ø-A
  • Tittel A-Ø
  • Tittel Ø-A
  • Type publikasjon A-Ø
  • Type publikasjon Ø-A
  • Eldste først
  • Nyeste først
  • Skapad (Eldste først)
  • Skapad (Nyeste først)
  • Senast uppdaterad (Eldste først)
  • Senast uppdaterad (Nyeste først)
  • Disputationsdatum (tidligste først)
  • Disputationsdatum (siste først)
  • Standard (Relevans)
  • Forfatter A-Ø
  • Forfatter Ø-A
  • Tittel A-Ø
  • Tittel Ø-A
  • Type publikasjon A-Ø
  • Type publikasjon Ø-A
  • Eldste først
  • Nyeste først
  • Skapad (Eldste først)
  • Skapad (Nyeste først)
  • Senast uppdaterad (Eldste først)
  • Senast uppdaterad (Nyeste først)
  • Disputationsdatum (tidligste først)
  • Disputationsdatum (siste først)
Merk
Maxantalet träffar du kan exportera från sökgränssnittet är 250. Vid större uttag använd dig av utsökningar.
  • 1.
    Abdelhamid, Hani
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK).
    Wilk-Kozubek, Magdalena
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK).
    Ahmed, M. El-Zohry
    Valiente, Alejandro
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Bermejo-Gomez, Antonio
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Martín-Matute, Belén
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Mudring, Anja-Verena
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK).
    Zou, Xiaodong
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK).
    Luminescence Properties for a Family of Highly Stable Lanthanide Metal-Organic FrameworksManuskript (preprint) (Annet vitenskapelig)
  • 2.
    Adrian Meredith, Jenny
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Björklund, Catarina
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Adolfsson, Hans
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Edlund, Michael
    Jansson, Katarina
    Lindberg, Jimmy
    Vrang, Lotta
    Hallberg, Anders
    Institutionen för läkemedelskemi, Uppsala universitet.
    Rosenquist, Åsa
    Samuelsson, Bertil
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Design and Synthesis of BACE-1 Inhibitors Containing a New Hydroxyethylene (HE) Scaffold: Potent activities in a cellular assayManuskript (Annet vitenskapelig)
    Abstract [en]

    In a preceding report from our group we disclosed the development of a novel HE transition state isostere with a difluorophenoxymethyl side chain in the P1 position and a methoxy group in the P1’ position furnishing highly potent inhibitors of BACE-1 (i.e. lead compound 1), which moreover exhibit very promising selectivity over cathepsin D. In a continuation of this work with the aim at improving on the cell-based activity and pharmacokinetic properties, we have further developed the SAR for the P1 side chain of inhibitor 1 whereby the P1 side chain oxygen has been substituted for an amine, a carbon or a bond. The chemistry developed for the previous HE inhibitor structure 1 has now been extended to readily accommodate the introduction of new P1 side chains into this new HE scaffold. These modifications have given rise to several highly potent inhibitors where the most potent displayed a BACE-1 Ki value of 0.2 nM and a cell-based Aβ40 IC50 value of 9 nM. Thus, regarding the enzyme inhibition in the cell assay a more than 600-fold improvement compared to compound 1 was achieved via minor structural alterations.

  • 3.
    Ahlsten, Nanna
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Bermejo-Gómez, Antonio
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Martín-Matute, Belén
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Synthesis of α-chlorinated ketones and aldehydes: Iridium-catalyzed tandem 1,3-H shift/chlorination of allylic alcoholsManuskript (preprint) (Annet vitenskapelig)
  • 4.
    Anderlund, Magnus F.
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Högblom, Joakim
    Shi, Wei
    Huang, Ping
    Eriksson, Lars
    Weihe, Högni
    Styring, Stenbjörn
    Åkermark, Björn
    Magnuson, Ann
    Synthesis, Structure and Redox Chemistry of a Dinuclear Manganese Complex with a Novel Unsymmetric N5O2 LigandManuskript (Annet vitenskapelig)
  • 5.
    Angles d'Ortoli, Thibault
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Mobarak, Hani
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Ståhle, Jonas
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Hamark, Christoffer
    Fontana, Carolina
    Engström, Olof
    Apostolica, Patricia
    Widmalm, Göran
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Complete 1H and 13C NMR chemical shift assignments of mono- to tetrasaccharides as basis for NMR chemical shift predictions of oligo- and polysaccharides using the computer program CASPERManuskript (preprint) (Annet vitenskapelig)
  • 6.
    Ayesa, Susana
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Maltseva, Tatiana
    Rakos, Laszlo
    Hamelink, Elisabeth
    Classon, Björn
    Samuelsson, Bertil
    Investigation of Allylic Alcohols in the P1 Position of Inhibitors of Hepatitis C Virus NS3 ProteaseManuskript (Annet vitenskapelig)
  • 7.
    Bartholomeyzik, Teresa
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Investigation of Selectivity in Palladium-Catalyzed Oxidative Arylating Carbocyclization of Allenynes.Manuskript (preprint) (Annet vitenskapelig)
  • 8.
    Bartholomeyzik, Teresa
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Pendrill, Robert
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Jiang, Tuo
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Widmalm, Göran
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Bäckvall, Jan-E.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Complex Kinetics in a Palladium(II)-Catalyzed Oxidative Carbocyclization: Untangling of Competing Pathways, Pre-Catalyst Activation, and Product MixturesManuskript (preprint) (Annet vitenskapelig)
  • 9.
    Bermejo-Gómez, Antonio
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Ahlsten, Nanna
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Martín-Matute, Belén
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Synthesis of 4,5-disubstituted 2-amino-1,3-thiazoles from α,β-unsaturated ketones: Preparation of 5-Benzyl-4-methyl-1,3-thiazol-2-amine hydrochlorideManuskript (preprint) (Annet vitenskapelig)
  • 10. Bogár, Krisztián
    et al.
    Krumlinde, Patrik
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Bäckvall, Jan-Erling
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Hydrogenized Wilkinson´s Catalyst for Transfer Hydrogenation of Carbonyl CompoundsManuskript (preprint) (Annet vitenskapelig)
    Abstract [en]

    Combining the advantages of homogeneous and heterogeneous catalysis is possible by heterogenization of homogeneous transition metal complexes based on a grafting/anchoring technique. Wilkinson’s catalyst ((RhCl(PPh3)3) immobilized on common silica showed high activity and selectivity in transfer hydrogenation reactions of different carbonyl compounds in isopropanol. Reactions conducted at reflux in isopropanol afforded the corresponding carbinols in high yields in short reaction times. The heterogeneous feature of the catalyst allows easy recovery and efficient reuse in the same reaction up to 5 times without loss of catalytic activity.

  • 11.
    Bogár, Krisztián
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Martín-Matute, B.
    Bäckvall, Jan-E.
    Large Scale Metalloenzymatic Dynamic Kinetic Resolution of (rac)-1-PhenylethanolManuskript (Annet vitenskapelig)
  • 12. Borgström, Magnus
    et al.
    Shaikh, Nizamuddin
    Johansson, Olof
    Anderlund, Magnus F.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Styring, Stenbjörn
    Åkermark, Björn
    Magnuson, Ann
    Hammarström, Leif
    Light Induced Magnanese Oxidation and Long-lived Charge Separation in a Mn2II,II-RuII-acceptor triadManuskript (Annet vitenskapelig)
  • 13.
    Bunrit, Anon
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Srifa, Pemikar
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Dahlstrand, Christian
    Huang, Genping
    Biswas, Srijit
    Himo, Fahmi
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Watile, Rahul
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Samec, Joseph
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    H3PO2-Catalyzed Intramolecular Stereospecific Substitution of the Hydroxyl Group in Stereogenic Secondary Alcohols by N-, O-, and S-centered Nucleophiles to Generate HeterocyclesManuskript (preprint) (Annet vitenskapelig)
    Abstract [en]

    The direct intramolecular stereospecific substitution of the hydroxyl group in stereogenic secondary alcohols was successfully accomplished by phosphinic acid catalysis. The hydroxyl group was displaced by O-, S-, and N-centered nucleophiles to provide enantioenriched five- and six-membered heterocycles in good to excellent yields and high enantiospecificity with water as the only by product. Mechanistic studies using both experiments and calculations have been performed. Rate order determination shows first-order dependences in catalyst, internal nucleophile, and electrophile concentrations, however, independence on external nucleophile and electrophile. Furthermore, phosphinic acid does not promote SN1 reactivity. Computational studies support a bifunctional role of the phosphinic acid in which activations of both nucleofuge and nucleophile occur in a bridging SN2-type transition state. 

  • 14.
    Bunrit, Anon
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Watile, Rahul
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Lagerspets, Emi
    Lanekoff, Ingela
    Biswas, Srijit
    Repo, Timo
    Samec, Joseph
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Iron (III)-Catalyzed Intramolecular Stereospecific Substitution of the OH Group in Stereogenic Secondary and Tertiary AlcoholsManuskript (preprint) (Annet vitenskapelig)
    Abstract [en]

    We herein report a Fe(OTf)3-catalyzed stereospecific substitution of the hydroxyl (OH) group in secondary and tertiary alcohols by N-, and O-centered nucleophiles to generate synthetically precious enantioenriched pyrrolidines, tetrahydrofuran, 1,2,3,4-tetra-hydroquinolines, and chromanes. The substitution of the OH group in benzylic, allylic, and aliphatic alcohols proceed with high yields and high degree of enantiospecificity to give saturated five- and six-membered heterocyclic products and water as the only by-product. Mechanistic studies revealed that the intramolecular substitution reaction proceeds through an SN2 reaction with secondary alcohols and an SN1 reaction, comprising a tight ion pair, with tertiary alcohols giving products with inversion of configuration at the stereogenic carbon in both cases. The iron interacts with both nucleofile and nucloefuge, where the latter leads to a controlled carbon−oxygen (C–O) bond cleavage. The procedure opens up new atom efficient technique for catalytic stereospecific reactions that allow easily accessible stereogenic secondary and tertiary alcohols to be considered as substrates in substitution reactions. 

  • 15.
    Carson, Fabian
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK).
    Martínez-Castro, Elisa
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Marcos, Rocío
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    González Miera, Greco
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Jansson, Kjell
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK).
    Zou, Xiaodong
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK).
    Martín-Matute, Belén
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Introduction of an N-heterocyclic Carbene Iridium Complex into a Zirconium Metal–Organic Framework for CatalysisManuskript (preprint) (Annet vitenskapelig)
  • 16.
    Colas, Kilian
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Vieira Dias dos Santos, Ana Catarina
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Mendoza, Abraham
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    One-pot Synthesis of Ketones from Aliphatic Carboxylic Acids Using Grignard Reagents and an in situ generated turbo-Hauser BaseManuskript (preprint) (Annet vitenskapelig)
  • 17.
    Colas, Kilian
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Vieira Dias dos Santos, Ana Catarina
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Mendoza, Abraham
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Synthesis of Ketones from Carboxylic Acids Using Grignard Reagents and turbo-Hauser BasesManuskript (preprint) (Annet vitenskapelig)
  • 18. Cumpstey, Ian
    et al.
    Frigell, jens
    Pershagen, Elias
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Alonzi, D.S.
    Butters, T.D.
    N-linked neodisaccharides: Synthesis facilitated by the enhanced reactivity of allylic electrophiles, and glycosidase inhibitory activityManuskript (preprint) (Annet vitenskapelig)
    Abstract [en]

    Neodisaccharides consisting of two monosaccharides linked by a bridging nitrogen atom have been synthesised. Converting one of the monosaccharide coupling components into an unsaturated derivative enhances its electrophilicity at the allylic position, facilitating coupling reactions. Mitsunobu coupling between nosylamides and 2,3-unsaturated 4-alcohols gave the 4-amino pseudodisaccharides with inversion of configuration as single regio- and diastereoisomers. A palladium catalysed coupling between an amine and a 2,3-unsaturated 4-trichloroacetimidate gave a 2-amino pseudodisaccharide as the major product along with other minor products. Derivatisation of the C=C double bond in pseudodisaccharides allowed the formation of Man(N4–6)Glc and Man(N4–6)Man neodisaccharides. The inhibitory activity of some N-linked neodisaccharides against the enzyme α-Glucosidase II is reported.

  • 19.
    Cumpstey, Ian
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Ramstadius, Clinton
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Borbas, Katalin Eszter
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Alonzi, Dominic
    Oxford University.
    Butters, Terry
    Oxford University.
    Coupling reactions of valienol C-1 electrophiles for valienamine pseudodisaccharide synthesis: synthesis and α-Glucosidase II inhibitory activity of pseudodisaccharides relevant to N-glycan biosynthesisManuskript (preprint) (Annet vitenskapelig)
  • 20.
    Daver, Henrik
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Algarra, Andrés G.
    Rebek, Jr., Julius
    Harvey, Jeremy N.
    Himo, Fahmi
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Toward Accurate Quantum Chemical Modeling of Water-Soluble Self-Assembled CapsulesManuskript (preprint) (Annet vitenskapelig)
  • 21.
    Dziedzic, Pawel
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Zhao, Gui-ling
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Córdova, Armando
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Practical amino acid-catalyzed asymmetric synthesis pf protected α-hydroxy-amino aldehydes and acidsManuskript (preprint) (Annet vitenskapelig)
  • 22.
    Edin, Michaela
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Martín-Matute, Belén
    Bäckvall, Jan-E.
    Dynamic kinetic asymmetric transformation of 1,2-diols: an enantioselective synthesis of syn-1,2-diacetatesManuskript (Annet vitenskapelig)
  • 23.
    Eklund, Robert
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Lycknert, Kristina
    Söderman, Peter
    Widmalm, Göran
    Söderman,
    A conformational dynamics study of a-L-Rhap-(1-->2)[a-L-Rhap-(1-->3)]-a-L-Rhap-OMe in solution by NMR experiments and molecular simulationsManuskript (Annet vitenskapelig)
  • 24.
    Erbing, Elis
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Selective C-H Iodination of Benzamides and Weinreb Amides through Iridium and Acid CatalysisManuskript (preprint) (Annet vitenskapelig)
  • 25.
    Eriksson, Kristofer
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Verho, Oscar
    Nyholm, Leif
    Oscarsson, Sven
    Bäckvall, Jan Erling
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Electrochemical Preparation of Dispersed Gold Nanoparticles Supported in the Pores of Siliceous Mesocellular Foam: An Efficient Catalyst for Cycloisomerization of 4-Alkynoic Acids to LactonesManuskript (preprint) (Annet vitenskapelig)
    Abstract [en]

    A versatile approach for the production of dispersed thiol-stabilized gold nanoparticles in the pores of siliceous mesocellular foam (MCF) is described and the thiol-stabilized gold nanoparticles were found to catalyze the cyclization of 4-pentynoic acids to lactones. The reported method is based on an electrochemical oxidation of a gold substrate generating oxidative Au(III) species which give rise to a surface-confined redox reaction yielding MCF supported Au(I)-thiolates. By reducing the MCF-S-Au(I) complex with sodium borohydride thiol-stabilized gold nanoparticles were obtained which were characterized with Transmission Electron Microscopy (TEM). The nanoparticles were found to be in the size of 1-8 nm. Inductive Coupled Plasma (ICP) analysis indicated an Au loading of 3 % (w/w) on the MCF. Further 0.5 mol% of the MCF-S-Au(0) solids were used to catalyze the cyclization reaction of 4-alkynoic acid under mild conditions with high selectivity (> 99%).

  • 26.
    Fontana, Carolina
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Holst, Otto
    Moriyón, Ignacio
    Widmalm, Göran
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Structural studies of the rough lipopolysaccharides of Brucella melitensis mutants affected in the biosynthesis of the core and O-antigen polysaccharideManuskript (preprint) (Annet vitenskapelig)
  • 27.
    Fransson, Ann-Britt L.
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Leijondahl, Karin
    Bäckvall, Jan-Erling
    Highly Efficient Ru-catalyzed Transfer Hydrogenation/Hydrogenation Procedure for 1,3-Cycloalkandiols using Controlled Microwave HeatingManuskript (Annet vitenskapelig)
  • 28.
    Frigell, Jens
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Cumpstey, Ian
    Carbasugar analogues of galactofuranose: α-O-linked derivativesManuskript (preprint) (Annet vitenskapelig)
    Abstract [en]

    Using an indirect method, we have synthesised α-linked carbasugar analogues of galactofuranosides for the first time. Opening of a β-talo configured carbasugar 1,2-epoxide by alcohol nucleophiles under Lewis acidic conditions proceeded with very good regioselectivity to give α-talo configured C-1-substituted ethers with OH-2 free. Inversion of configuration at OH-2 by an oxidation–reduction sequence gave the α-galacto configured carbahexofuranose C-1 ethers. A carbadisaccharide corresponding to the Galf(α1→3)Manp substructure from Apodus deciduus galactomannan was synthesised to exemplify the method.

  • 29.
    Frigell, Jens
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Eriksson, Lars
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK).
    Cumpstey, Ian
    Carbasugar analogues of galactofuranosides: β-O-linked derivativesManuskript (preprint) (Annet vitenskapelig)
    Abstract [en]

    A selectively protected carbasugar analogue of β-galactofuranose was synthesised from glucose using ring-closing metathesis as the key step. The carbasugar was converted into an α-galacto configured 1,2-epoxide, which was an effective electrophile in Lewis acid catalysed coupling reactions with alcohols. The epoxide was opened with regioselective attack at C-1 to give β-galacto configured C-1 ethers. Using carbohydrates as nucleophiles, we synthesised a number of pseudodisaccharides.

  • 30.
    Frigell, Jens
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Pearcey, J.A.
    Lowary, T.
    Cumpstey, Ian
    Carbasugar Analogues of Galactofuranose: Pseudodisaccharide Mimics of Fragments of Mycobacterial ArabinogalactanManuskript (preprint) (Annet vitenskapelig)
    Abstract [en]

    A partially protected carbasugar analogue of β-galactofuranose was converted into an α-galacto configured 1,2-epoxide, which was was opened by alcohols under Lewis acid catalysis with regioselective attack at C-1 to give β-galacto configured C-1 ethers. Using OH-5 and OH-6 carbagalactofuranose derivatives as nucleophiles, we synthesised pseudodisaccharide analogues of substructures of the arabinogalactan from M. tuberculosis. The dicarba analogue of the disaccharide Galf(β1→5)Galf was found to moderately inhibit the action of GlfT2 galactofuranosyl transferase from M. tuberculosis.

  • 31.
    Fryxelius, Jacob
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Anderlund, Magnus
    Xu, Yunhua
    Huang, Ping
    Magnuson, Ann
    Sun, Licheng
    Åkermark, Björn
    A Tetranuclear Mn Dimer of DimersManuskript (Annet vitenskapelig)
  • 32.
    Gemma, Emiliano
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Lahmann, Martina
    Oscarson, Stefan
    Synthesis of monodeoxy analogues of the trisaccharide α-D-Glcp-(1→3)-α-D-Manp-(1→2)-α-D-ManpManuskript (Annet vitenskapelig)
  • 33.
    Gustafson, Karl P. J.
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Guðmundsson, Arnar
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Bajnóczi, Éva
    Ning, Yuan
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK).
    Persson, Ingmar
    Bäckvall, Jan-Erling
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    In-Situ Structure Determination of a Ruthenium Racemization Catalyst and its Activated Intermediates using X-ray Absorption SpectroscopyManuskript (preprint) (Annet vitenskapelig)
  • 34.
    Gustafson, Karl P. J.
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Görbe, Tamás
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    de Gonzalo Calvo, Gonzalo
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Yuan, Ning
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK).
    Schreiber, Cynthia
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Shchukarev, Andrey
    Tai, Cheuk-Wai
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK).
    Persson, Ingmar
    Bäckvall, Jan-Erling
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Application and further structure elucidation of Pd(0)-CalB CLEA biohybrid catalyst- Chemoenzymatic dynamic kinetic resolution of primary benzylic aminesManuskript (preprint) (Annet vitenskapelig)
  • 35.
    Guðmundsson, Arnar
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Gustafson, Karl P. J.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Khanh Mai, Binh
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Hobiger, Viola
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Yang, Bin
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Himo, Fahmi
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Bäckvall, Jan-Erling
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Iron Catalyzed Cyclization of N-protected a-Allenic Amines to 2,3-dihydropyrrolesManuskript (preprint) (Annet vitenskapelig)
  • 36.
    Görbe, Tamás
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Löfgren, Johanna
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Oschmann, Michael
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    S. Humble, Maria
    Bäckvall, Jan-Erling
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Transesterification of tert-Alcohols by Engineered Candida antarctica Lipase AManuskript (preprint) (Annet vitenskapelig)
  • 37.
    Hamark, Christoffer
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Berntsson, Ronnie Per-Arne
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för biokemi och biofysik.
    Gustafsson, Robert
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för biokemi och biofysik.
    Svensson, Linda M.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för biokemi och biofysik.
    Stenmark, Pål
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för biokemi och biofysik.
    Widmalm, Göran
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Recognition of Ganglioside Receptors by Botulinum Neurotoxin AManuskript (preprint) (Annet vitenskapelig)
  • 38.
    Johansson, Olof
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Lomoth, Reiner
    Sun, Licheng
    Åkermark, Björn
    Linkage Isomerism in a Bistridentate Ruthenium(II) ComplexManuskript (Annet vitenskapelig)
  • 39.
    Johansson, Tommy
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Stawinski, Jacek
    Synthesis of a Nucleotide Unit for the Incorporation of a Terminal 5'-pyridylphosphonate Moiety into OligonucleotidesManuskript (Annet vitenskapelig)
  • 40.
    Johansson, Tommy
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Stawinski, Jacek
    Towards Nucleotide Analogues with Metal Complexing Proprties. Synthesis of Dinucleoside Terpyridyl- and BipyridylphosphonatesManuskript (Annet vitenskapelig)
  • 41.
    Jonsson, Hanna
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Säwén, Elin
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Widmalm, Göran
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Studies on the conformational flexibility of α-L-Rhap-(1→2)-α-L-Rhap-OMe using molecular simulation and 13C-site-specific labeling: a model for a commonly occurring disaccharide in bacterial polysaccharidesManuskript (preprint) (Annet vitenskapelig)
    Abstract [en]

    Bacterial polysaccharides are comprised of a variety of monosaccharides, L-rhamnose (6-deoxy-Lmannose) being one of them. This sugar is often part of α-(1→2)- and/or α-(1→3)-linkages and wehave therefore studied the disaccharide α-L-Rhap-(1→2)-α-L-Rhap-OMe to obtain information onconformational preferences at this glycosidic linkage. The target disaccharide was synthesized with 13C site-specific labeling at C1' and at C2', i.e., in the terminal group. 2D 1H,13C-HSQC-HECADE and 1H,13C-J-HMBC NMR experiments, 1D 13C and 1H NMR spectra together with total line-shape analysis were used to extract conformationally dependent hetero- and homonuclear spin-spincoupling constants. This resulted in the determination of 2JC2',H1' , 3JC1',C1 , 3JC1',C3 , 3JC2',C2 , 2JC1',C2 ,1JC1',C2' , and 1JC1',H1' . These data together with previously determined JC,H and 1H,1H NOEs result in fourteen conformationally dependent NMR parameters that are available for analysis of glycosidiclinkage flexibility and conformational preferences. A molecular dynamics simulation of the disaccharide with explicit water molecules as solvent showed a major conformational state at ΦH =40° and ψH = –35°, consistent with experimental NMR data.

  • 42.
    Jonsson, Hanna
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Widmalm, Göran
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    NMR analysis of conformationally dependent nJCH and nJCC in the trisaccharide α-L-Rhap-(1→2)[α-L-Rhap-(1→3)]-α-L-Rhap-OMe and a site-specifically labeled isotopologue thereofManuskript (preprint) (Annet vitenskapelig)
    Abstract [en]

    An array of NMR spectroscopy experiments have been carried out to obtain conformationallydependent 1H,13C- and 13C,13C-spin-spin coupling constants in the trisaccharide a-L-Rhap-(1®2)[a-LRhap-(1®3)]-a-L-Rhap-OMe. The trisaccharide was synthesized with 13C site-specific labeling at C2'and C2'', i.e., in the rhamnosyl groups in order to alleviate 1H spectral overlap. Using both the naturalabundance compound and the 13C-labeled sample 2D 1H,13C-J-HMBC and 1H,13C-HSQC-HECADENMR experiments, total line-shape analysis of 1H NMR spectra and 1D 13C NMR experiments wereemployed to extract 3C,H J , 2C,H J , 3C,C J , and1C,C J . The 13C site-specific labeling facilitates straightforward determination of nC,C J as the splitting of the 13C natural abundance resonances. This studyresulted in seven conformationally dependent coupling constants for the trisaccharide and illustrates theuse of 13C site-specific labeling as a valuable tool that extends the 1D and 2D NMR methods in currentuse to attain both hetero- and homonuclear spin-spin coupling constants.

  • 43. Kang, Yu
    et al.
    Gohlke, Ulrich
    Engström, Olof
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Hamark, Christoffer
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Scheidt, Tom
    Heinemann, Udo
    Max-Delbrück-Centrum für Molekulare Medizin.
    Widmalm, Göran
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Lipowski, Reinhard
    Santer, Mark
    Barbirz, Stefanie
    Probing the conformational space of Shigella flexneri O‑antigen bound to the tailspike protein of bacteriophage Sf6 by X-ray crystallography, NMR, and Molecular DynamicsManuskript (preprint) (Annet vitenskapelig)
  • 44. Karlsson, Erik A.
    et al.
    Lee, Bao-Lin
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Liao, Rong-Zhen
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Åkermark, Torbjörn
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK).
    Kärkäs, Markus D.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Becerril, Valeria Saavedra
    Abrahamsson, Maria
    Siegbahn, Per E. M.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Zou, Xiaodong
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK).
    Åkermark, Björn
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Synthesis and electron transfer processes in a new family of coupled Mn2–Ru complexesManuskript (preprint) (Annet vitenskapelig)
  • 45.
    Kerdphon, Sutthichat
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Ponra, Sudipta
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Yang, Jianping
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Wu, Haibo
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Andersson, Pher G.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Iridium-Catalyzed Enantio- and Diastereoselective Hydrogenation of Acyclic Tetra-Substituted OlefinsManuskript (preprint) (Annet vitenskapelig)
  • 46.
    Krajangsri, Suppachai
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Wu, Haibo
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Liu, Jianguo
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Rabten, Wangchuk
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Andersson, Pher
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Chemoselective Iridium-catalysed Peterson olefination/Asymmetric Hydrogenation of beta-Hydroxy SilanedManuskript (preprint) (Annet vitenskapelig)
    Abstract [en]

    Herein we report the use of Ir-N,P catalysts for the asymmetric hydrogenation of β-hydroxy silanes via an in-situ generated olefin intermediate. The reaction proceeds via an acid catalysed Peterson olefination reaction and provides hydrogenated products in excellent ee’s of up to 99% accompanied with high isolated yields under mild reaction conditions and short reaction times. Modification of the reaction conditions provides a choice to hydrogenate either an olefin or a β-hydroxy silane in a chemo-selective manner leaving the other functionality unaffected in the product.

  • 47.
    Krajangsri, Suppachai
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Yang, Jianping
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Massaro, Luca
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Andersson, Pher
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Iridium-Catalysed Enantioselective Hydrogenation of Enamides2018Manuskript (preprint) (Annet vitenskapelig)
    Abstract [en]

    A variety of oxazolidinone-enamides were prepared and evaluated in this reaction. High yields, (up to 99%) and excellent ee, (up to 99%) were obtained.

  • 48.
    Kullberg, Martin
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Stawinski, Jacek
    Synthetic and 31P NMR studies on the preparation and oxidation of dinucleoside H-phosphonoselenoatesManuskript (Annet vitenskapelig)
  • 49.
    Kärkäs, Markus D.
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Laine, Tanja M.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Åkermark, Torbjörn
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK).
    Åkermark, Björn
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Molecular Single-site Ruthenium Complexes Containing a Basic Site: The Use of Structure-activity RelationshipsManuskript (preprint) (Annet vitenskapelig)
    Abstract [en]

    A series of single-site ruthenium(III) complexes (2a-d) were synthesized and characterized, and employed in the oxidation of H2O. A linear free-energy relationship study was conducted in order to establish a correlation between the electrochemical properties and the electronic parameters of the introduced substituents in complexes 2a-d.

  • 50.
    Landström, Jens
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Bergström, Maria
    Naturvetenskapliga institutionen, Högskolan i Kalmar.
    Hamark, Christoffer
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Ohlson, Sten
    Naturvetenskapliga institutionen, Högskolan i Kalmar.
    Widmalm, Göran
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Combining WAC, NMR and computer simulations in Lysozyme interaction studiesManuskript (Annet vitenskapelig)
123 1 - 50 of 104
RefereraExporteraLink til resultatlisten
Permanent link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf