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  • 1.
    Sjölin, Olof
    KTH, Skolan för kemivetenskap (CHE).
    Synthesis of Substituted Pyrrolidines2016Independent thesis Advanced level (degree of Master (Two Years)), 20 poäng / 30 hpOppgave
    Abstract [en]

    The task of medicinal chemists in a drug discoveryproject is to synthesize/design analogues to the screening hits, simultaneouslyincreasing target potency and optimizing the pharmacological properties.  This requires a wide selection of moleculesto be synthesized, where both synthetic feasibility and price of startingmaterials are of great importance. In this work, a synthetic pathway from cheapand readily available starting materials to highly modifiable 2,4-disubstitutedpyrrolidines is demonstrated. Previously reported procedures to similarpyrrolidines use expensive catalysts, requires harsh conditions and requiresnon-commercially available starting materials. The suggested pathway herein has demonstrated great possibility forvariation in the 4-position, including fluoro, difluoro, nitrile and alcoholfunctional groups. There are several areas in which the synthesis can beimproved and expanded upon. Improvements can be made by optimizing thedescribed reaction conditions and further expansion of possible modificationsin both 2- and 4-position could be explored.

  • 2.
    Starkholm, Allan
    KTH, Skolan för kemivetenskap (CHE).
    Synthesis of Water-Soluble Catalysts for Olefin Metathesis2016Independent thesis Advanced level (degree of Master (Two Years)), 20 poäng / 30 hpOppgave
    Abstract [en]

    The need of efficient and sustainable chemical processes in the field of organic chemistry is essential in order to meet the environmental demands that societies and industries require from us. One key chemical reaction that is widely used in industrial plants is olefin metathesis, a reaction that involves exchange and formation of C-C double bonds. It is a crucial reaction in polymerization reactions and as a means of connecting building blocks together. Consequently it is necessary to enable these reactions to work in aqueous media for increased sustainability and for applications in biochemistry. Carbenes are a class of compounds that constitute a crucial role as ligands in olefin metathesis catalysts. This project will aim to explore the water applicability of a certain category of carbenes, cyclic (alkyl)-(amino)carbenes (CAAC), which recently have caught attention due to their remarkable catalytic activity in organometallic catalysis. The CAAC based catalysis display high stability towards air and moisture, and thus making them attractive alternatives for industrial applications. Throughout the project, synthetic routes towards water soluble CAAC:s have been designed and investigated. Moreover, an approach of evaluating a CAAC-ruthenium catalyst in micellar solutions have been investigated and illustrated promising results regarding activity and stability.

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