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  • 1.
    Lidman, Martin
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
    Micro Scale Synthesis of Tritium LabeledIsoallopregnanolone for Use in RIA-analysis2010Självständigt arbete på avancerad nivå (masterexamen), 20 poäng / 30 hpStudentuppsats (Examensarbete)
    Abstract [en]

    In this thesis it was shown that Isoallopregnanolone can be synthesized from

    Allopregnanolone by the Mitsunobu reaction as well as by oxidation with o-iodoxybenzoic

    acid (IBX) with subsequent reduction with NaBH

    4. It was shown that the oxidation with

    subsequent reduction was a better method for synthesis in microgram scale. The oxidationreduction

    method was carried out in microgram scale on tritium labeled Allopregnanolone

    (Pregnane-3α-ol-20one, 5α[9,11,12-

    3H(N)] to produce the corresponding tritium labeled

    Isoallopregnanolone. The possibility of synthesizing Tetrahydrodeoxycorticosterone

    (THDOC) from Allopregnanolone in microgram scale was examined. Formation of a

    silylenol ether analog of Allopregnanolone and subsequent oxidation with m-CPBA was

    examined as a method to synthesizing THDOC. The synthesis of THDOC by this procedure

    was found not to be efficient enough to be used in microgram scale

  • 2.
    Thinprakong, Chorpure
    Linköpings universitet. Linköpings universitet, Institutionen för fysik, kemi och biologi, Biomolekylär och Organisk Elektronik.
    Excitation transfer between conjugated polyelectrolytes and triplet emitter confined in protein nanowires2010Självständigt arbete på avancerad nivå (masterexamen), 20 poäng / 30 hpStudentuppsats (Examensarbete)
    Abstract [en]

    Phosphorescent metal complexes can be incorporated into amyloid-like fibrils, and these fibrils can be decorated with conjugated polyelectrolytes (CPEs). In this study, fac-tris[2-phenylpyridinato-C2,N]irdium(III) complexes [Ir(piq)3] were used as the phosphorescence emitter and Sodium-poly(3-thiophene acetic acid) (PTAA-Na) compounds were used as CPEs. Herein we study the energy transfer processes between the iridium complexes and the CPEs. To investigate these mechanisms, the analysis of the emission quenching and time-resolved measurements were done. Our measurements show that energy can be transfered from singlet state of PTAA to the singlet state of Ir(piq)3. Moreover, incorporation of iridium into amyloid fibrils decreases the importance of energy transfer by the Dexter mechanism. Finally we propose a geometry of interaction to explain the obtained results.

  • 3.
    Trupina, Snjezana
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Organisk Kemi. Linköpings universitet, Institutionen för fysik, kemi och biologi.
    Synthesis of Metalloporphyrins with Oligothiophenes as Probes for Amyloid Diseases2010Självständigt arbete på avancerad nivå (masterexamen), 30 poäng / 45 hpStudentuppsats (Examensarbete)
    Abstract [en]

    Abnormal aggregation of misfolded proteins is related to numerous neurodegenerative diseases, which include Alzheimer’s, Parkinson’s disease and prion diseases. Luminescent conjugated probes (LCPs) have been used as dyes for these supramolecular assemblies termed amyloid fibrils. To these probes, metalloporphyrin (MP) derivates have been attached to achieve new spectroscopic properties, which will allow for new ways to study protein aggregation diseases.

    In this thesis the synthesis of two different LCPs anchored porphyrin derivates are described. The LCPs are synthesized from 3-thiopheneacetic acid and additional thiophene units are added with the use of Suzuki cross coupling reaction. The porphyrin is synthesized from pyrrol, benzaldehyde and methyl-4- formylbenzoate in a condensation reaction. In the first target molecule (TM) the porphyrin and thiophene are coupled with a spacer and the second one is a direct coupling between the two compounds.

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