Endre søk
Begrens søket
1 - 2 of 2
RefereraExporteraLink til resultatlisten
Permanent link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Treff pr side
  • 5
  • 10
  • 20
  • 50
  • 100
  • 250
Sortering
  • Standard (Relevans)
  • Forfatter A-Ø
  • Forfatter Ø-A
  • Tittel A-Ø
  • Tittel Ø-A
  • Type publikasjon A-Ø
  • Type publikasjon Ø-A
  • Eldste først
  • Nyeste først
  • Skapad (Eldste først)
  • Skapad (Nyeste først)
  • Senast uppdaterad (Eldste først)
  • Senast uppdaterad (Nyeste først)
  • Disputationsdatum (tidligste først)
  • Disputationsdatum (siste først)
  • Standard (Relevans)
  • Forfatter A-Ø
  • Forfatter Ø-A
  • Tittel A-Ø
  • Tittel Ø-A
  • Type publikasjon A-Ø
  • Type publikasjon Ø-A
  • Eldste først
  • Nyeste først
  • Skapad (Eldste først)
  • Skapad (Nyeste først)
  • Senast uppdaterad (Eldste først)
  • Senast uppdaterad (Nyeste først)
  • Disputationsdatum (tidligste først)
  • Disputationsdatum (siste først)
Merk
Maxantalet träffar du kan exportera från sökgränssnittet är 250. Vid större uttag använd dig av utsökningar.
  • 1.
    Kjellberg, Alexandra
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Studies of oligosaccharides and carbon-13 enriched bacterial polysaccharides using NMR spectroscopy and computer simulations1998Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    The conformation and dynamics of the trisaccharide methyl β-D-Glcp-(1--> 2)[β-D-Glcp-(1 --> 3)] α-D-Manp and its constituent disaccharides methyl β-D-Glcp-(1 --> 2) α-D-Manp and methyl β-D-Glcp-(1 --> 3) α-D-Manp have been studied using computer simulations and NMR spectroscopy. The computer simulations applied were Metropolis Monte Carlo simulations employing the HSEA force field and Langevin dynamics simulations using the PARM22 and CHEAT95 force fileds. The NMR methods used were measurement of long-range heteronuclear coupling constants across the glycosidic linkages, measurement of carbon-13 nuclear relaxation rates for the determination of dynamical parameters according the Lipari-Szabo "model free" approach and measurements of homonuclear NOE and TROE cross relaxation rates for the determination of proton-proton distances. Experimental data were then compared to the corresponding parameters extracted from the various computer simulations.

    Studies of the carbon-13 labelled O-polysaccharides from Escherichia coli O25 and O91 have also been performed. 13C-13C TOCSY experiments, with the spin-lock on the carbon-13 nuclei, were applied to sugar residues of different geometries. This circumvented the problem of hampered magnetisation transfer encountered in residues with 3JHH < 2Hz when the spin-lock is applied on the protons.The carbon-13 labelling was also used to demonstrate the biosynthesis of one of the substituents in the Escherichia coli O91 O-polysaccharide.

  • 2.
    Ruda, Katinka
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Synthesis of inositol phosphoglycans and analogues thereof1998Doktoravhandling, med artikler (Annet vitenskapelig)
    Abstract [en]

    This thesis describes the synthesis of inositol phosphoglycans (IPG) corresponding to glycosyl-phosphatidylinositol (GPI) anchors found on the cell surface of the parasite Leishmania. Synthesis of an IPG which is a putative second messenger for insulin, and of analogues thereof is also discussed.

    The IPG structures synthesized contain mono-, tri-, and hexasaccharides linked to an inositol phosphate. Analogues of the putative second messenger contain glucosamine, instead of myo-inositol phosphate, coupled to either phosphorylated D-mannose or phosphorylated L-fucose. The synthetic work involved the development of procedures for obtaining optically pure myo-inositol-glucosamine derivatives, the formation of phosphomono- and diesters (both cyclic and acyclic) and oligosaccharide synthesis.

1 - 2 of 2
RefereraExporteraLink til resultatlisten
Permanent link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf