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  • 4801.
    Sandberg, Erik
    et al.
    Linköping University, Department of Management and Engineering, Logistics & Quality Management. Linköping University, Faculty of Science & Engineering.
    Jafari, Hamid
    Jönköping University, Jönköping, Sweden.
    A systematic review of retail supply chain responsiveness2016Conference paper (Other academic)
  • 4802.
    Sandberg, Erik
    et al.
    Linköping University, Department of Management and Engineering, Logistics & Quality Management. Linköping University, Faculty of Science & Engineering.
    Jafari, Hamid
    Department of Industrial Engineering & Management, Jönköping University, Jönköping, Sweden.
    Retail supply chain responsiveness - A systematic literature review and future research agenda2016In: NOFOMA 2016 - Proceedings of the 28th Annual Nordic Logistics Research Network Conference, Turku, Finland: University of Turku / Turku School of Economics , 2016, p. 719-721Conference paper (Other academic)
  • 4803.
    Sandberg, Erik
    et al.
    Linköping University, Department of Management and Engineering, Logistics & Quality Management. Linköping University, Faculty of Science & Engineering.
    Mena, Carlos
    Cranfield University.
    Exploring strategic strengths and weaknesses of retail purchasing groups2015In: International Review of Retail Distribution & Consumer Research, ISSN 0959-3969, E-ISSN 1466-4402, Vol. 25, no 3, p. 276-297Article in journal (Refereed)
    Abstract [en]

    Retail purchasing groups consist of small, independent, specialised stores that join together and collaborate on purchasing and other areas. In comparison to large-scale corporate retail chains, often labelled mega-retailers, retail purchasing groups are based on collaborative external integration between a central unit and the independent, local dealers. The overall purpose of this research is to explore the specific characteristics that underscore a retail purchasing group. The paper has two research questions: (1) What are the strengths and weaknesses of a supply chain structure based on external integration?, and (2) In what areas is the purchasing groups’ ownership structure particularly advantageous in comparison to the mega-retailers’ vertically integrated organisations? This exploratory research is empirically grounded in a case study of two Swedish purchasing groups. The paper argues that under certain market conditions, a decentralised supply chain, which relies on collaborative external relationships, can provide a competitive alternative to a more traditional centralised structure.  The paper elaborate three areas where the structure is particularly advantageous: (1) service-based competition in an industry otherwise focused on cost leadership, (2) in-depth understanding of local conditions and presence, and (3) the ability to incorporate entrepreneurial strengths and innovations in the supply chain.

  • 4804.
    Sandberg, Erik
    et al.
    Linköping University, Department of Management and Engineering, Logistics & Quality Management. Linköping University, Faculty of Science & Engineering.
    Pal, Rudrajeet
    University of Borås, Sweden.
    Dynamic capabilities in the used clothing supply chain2017In: Proceedings of the 22nd International Symposium on Logistics (ISL 2017): Data Driven Supply Chains / [ed] K.S. Pawar, A. Potter and A. Lisec, Centre for Concurrent Enterprise, Nottingham University Business School, Jubilee Campus, Wollaton Road Nottingham, NG8 1BB, UK , 2017, p. 730-737Conference paper (Refereed)
    Abstract [en]

    The purpose of this paper is to identify the dynamic capabilities present - and the ones missing - in used clothing supply chains. Such capabilities ensure ability to cope with the rapidly changing conditions in the used clothing supply chain, by creating, modifying and renewing the existing resource base. Particular empirical focus in the paper is given to fashion retailers and charities operating on the Swedish market. Based on the dynamic capabilities classes of sensing, seizing and reconfiguring, empirical data exemplify contemporary dynamic capabilities present among these actors. Theory on dynamic capabilities has to a very limited extent been applied in a reverse supply chain setting. The used clothing supply chain offers an interesting case for the exploration of the dynamic capabilities needed in such a reverse supply chain environment

  • 4805.
    Sandberg, Erik
    et al.
    Linköping University, Department of Management and Engineering, Logistics & Quality Management. Linköping University, Faculty of Science & Engineering.
    Pal, Rudrajeet
    Department of Business Administration and Textile Management, University of Borås.
    Hemilä, Jukka
    VTT Technical Research Centre of Finland Limited.
    Exploring value creation and appropriation in the reverse clothing supply chain2018In: International Journal of Logistics Management, ISSN 0957-4093, E-ISSN 1758-6550, Vol. 29, no 1, p. 90-109Article in journal (Refereed)
    Abstract [en]

    Purpose – The purpose of this paper is to explore the processes of value creation and appropriation among companies in a reverse clothing supply chain. Design/methodology/approach – This research is based on an inductive case study approach at fashion retailers, charity organisations, commercial recyclers, and specialised sorting companies involved in take-back schemes for used clothes in the reverse clothing supply chain.

    Findings – Value creation and appropriation processes are illustrated for different members of the reverse clothing supply chain. Results of different types of value and value co-creation explain the relatively high degree of collaboration among members in the “beginning” of the reverse supply chain. Here, collaboration outmanoeuvres the traditional value appropriation mechanism of price negotiation.

    Research limitations/implications – This research does not cover all tiers in this global industry, and practices among different regions may hamper the generalisability of the findings presented. Practical implications – This research allows a comprehensive picture of the members in the reverse clothing supply chain and outlines some of the major processes involved, decisive for value creation, and appropriation.

    Originality/value – The research draws upon the value concept and combines processes of value creation and appropriation in one, single empirical study. By doing that, the research disseminates the reverse clothing supply chain in a new way and facilitates improved understanding of the structure and rationales for members taking part in it. 

  • 4806.
    Sandberg, Mats
    et al.
    Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, Faculty of Science & Engineering. Acreo Swedish ICT, Norrköping, Sweden; .
    Tordera, Daniel
    Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, Faculty of Science & Engineering.
    Granberg, Hjalmar
    Innventia AB, Stockholm, Sweden.
    Sawatdee, Anurak
    Acreo Swedish ICT, Norrköping, Sweden.
    Dedic, Dina
    Innventia AB, Stockholm, Sweden.
    Berggren, Magnus
    Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, Faculty of Science & Engineering.
    Jonsson, Magnus P
    Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, Faculty of Science & Engineering.
    Photoconductive zinc oxide-composite paper by pilot paper machine manufacturing2016In: Flexible and printed electronics, ISSN 2058-8585, Vol. 1, no 4, article id 044003Article in journal (Refereed)
    Abstract [en]

    Smartmaterials can be used for awide variety of applications, including sensing and energy harvesting.Implementation of smartmaterials in large area devices requires scalablemanufacturing. The use ofpaper-making techniques would offer an enormous production capacity, allowing for low-cost andlarge-scalemanufacturing. In thisworkwe present a successful pilot scale papermachinemanufacturingof functional composite papers (100mmin−1 with aweb width of 30 cm) based on cellulose fibres andcommercial tetrapodal zinc oxidemicrowhiskers (ZnO-Ts).Carbon electrodes could successfully beprinted on the paper to form complete electronic devices where the paper itself is the active material.Thisenabled development of aZnO-composite paper photosensor,where we characterized its stability,sensitivity and speed. The devices show excellent photosensing properties over awide range of lightirradiances (0.01–1Sun), including short response times (∼10 s) and long-term stability. Under simulatedsunlight and a bias voltage of 1 V, small (0.5 cm2) two-probe interdigitated photosensor devices provided12 μAphotocurrent.Under the same conditions, four-probe measurements of the composite papershowed a sheet resistance of 6.9·107Ω/sq. Four-probe measurements also demonstrated that the paperconductivity varies linearlywith light irradiance. To the best of ourknowledge, this is the first example ofpilot paper machine production of an optoelectronic paper, demonstrating the potential for large-scalepapermanufacturing of active smart paper from low-cost industrial bulk materials.

  • 4807.
    Sandewall, Erik
    Linköping University, Department of Computer and Information Science, Artificial Intelligence and Intergrated Computer systems. Linköping University, Faculty of Science & Engineering.
    Samtal om Sveriges nation2015Book (Other (popular science, discussion, etc.))
    Abstract [sv]

    Demokratin ifrågasätts i dagens värld genom att auktoritära och fundamentalistiska ideologier av flera slag förs fram som alternativ. De tillämpas i praktiken i ett flertal länder, men de sprids också genom aktiv propaganda. Den här boken utgår från föreställningen att detta utgör en utmaning även för vårt land, och den föreslår framförallt två åtgärder för att möta den utmaningen.

    Ett förslag är att precisera samhällets demokratiska grundsatser och att komplettera dem med några ytterligare punkter, såsom följande. En princip om assimilationsfrihet formuleras, alltså en rättighet att byta etnisk, religiös eller politisk tillhörighet om man vill, och samtidigt förstås en rättighet att bevara den man har. I boken föreslås utvidgat skydd för dessa rättigheter. Likaså införs begreppet religionism, alltså hävdandet att en viss religion är överlägsen andra och är förutbestämd att ta över, och det föreslås att religionism ska likställas med rasism.

    Det andra huvudförslaget är att betrakta nationen som bäraren av detta utvidgade demokratibegrepp, men då handlar det om nationen i en annan bemärkelse än vad dagens `nationalister' föreställer sig. Boken anknyter till skillnaden mellan etnisk och samhällelig nationalism (`civic nationalism' på engelska). I den förra sökerman göra en etnisk grupp till en nation, i den senare ses nationen som fundamentet för staten och samhället, och som den samlande faktorn för alla medborgare som ansluter sig till det demokratiska samhällets principer.

    Boken hävdar också att en kunskap om Sveriges historia ur politisk och religiös synpunkt är viktig för att kunna relatera till de främmande ideologierna och för attförstå hur vår samhällsmodell förhåller sig till deras.

  • 4808.
    Sandin Bülow, Kersti
    Linköping University, Department of Management and Engineering, Carl Malmsten - furniture studies. Linköping University, Faculty of Science & Engineering.
    Josef Franks rum: arkitekten som rumsgestaltare2016In: Carl Malmsten Furniture Studies: Josef Frank : studenter och lärare vid Carl Malmsten Furniture Studies utforskar Josef Frank / [ed] Chandra Ahlsell, Johan Knutsson, Maria Leijonhielm, Kersti Sandin Bülow, Lidingö: Carl Malmsten Furniture Studies , 2016, p. 32-41Chapter in book (Other (popular science, discussion, etc.))
  • 4809.
    Sandin, Jörgen
    Linköping University, Department of Management and Engineering, Project Innovations and Entrepreneurship. Linköping University, Faculty of Science & Engineering.
    Procuring industrial service solutions, Exploring enablers for co-creating value2015In: 7TH INDUSTRIAL PRODUCT-SERVICE SYSTEMS CONFERENCE - IPSS, INDUSTRY TRANSFORMATION FOR SUSTAINABILITY AND BUSINESS, ELSEVIER SCIENCE BV , 2015, Vol. 30, p. 7-12Conference paper (Refereed)
    Abstract [en]

    Optimizing complex hardware and services into service solutions may significantly reduce the total product life-cycle cost for a customer. Research regarding the customers perspective is still scarce, however. Hence, the purpose of this paper is to explore value perceptions among buyers of industrial service solutions developed for complex product platforms. The study is based on the experiences of one commercial and three governmental customers procuring service solutions for aviation products. As could be expected, direct financial benefits in the form of cost reduction were an important motive for the studied organizations. In reality, however, it turned out to be difficult to verify if these goals had been fulfilled. This may be seen both as an indicator of the complexity of the business, and the lack of clear baseline data, when the new service provider entered the field. Still, the customers were satisfied with the partnership, with several of them eager to learn from the provider, even if the learning process was painful. During the procurement process itself the quality and richness of the relationship with the new partner was important for signaling capability. End-users, however, seemed to be under-used and not sufficiently involved in the relationship during this process. The results also show that continuous proposals for improvements from the service provider are highly valued among customers. (C) 2015 The Authors. Published by Elsevier B.V.

  • 4810.
    Sandin, Jörgen
    et al.
    Linköping University, Department of Management and Engineering, Project Innovations and Entrepreneurship. Linköping University, Faculty of Science & Engineering.
    Berggren, Christian
    Linköping University, Department of Management and Engineering, Project Innovations and Entrepreneurship. Linköping University, Faculty of Science & Engineering.
    A simplified service engineering approach used by an industrial service solutions provider2015In: 7TH INDUSTRIAL PRODUCT-SERVICE SYSTEMS CONFERENCE - IPSS, INDUSTRY TRANSFORMATION FOR SUSTAINABILITY AND BUSINESS, ELSEVIER SCIENCE BV , 2015, Vol. 30, p. 30-35Conference paper (Refereed)
    Abstract [en]

    This paper shows how a provider of complex hardware with long operation times makes use of a structured methods approach to develop maintenance, repair and overhaul services and improve its service solutions. Service engineering is a methodical approach for the design of service offerings, and can be described by using the dimensions outcome, structure, process and management. So far, little is known about how firms implement such approaches. On the basis of a longitudinal case study within a large, product-based, high-technology business corporation, the paper shows that the use of a simplified service engineering model may be effective in supporting both the development and the maintenance of a comprehensive service business. More specifically, the case suggests the following factors to be important for success: A systematically applied engineering method, the presence of dedicated service champions, an ability to articulate and formalize new service roles, and deep technical knowledge of the involved hardware. (C) 2015 The Authors. Published by Elsevier B.V

  • 4811.
    Sandin, Linnea
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Medicine and Health Sciences.
    Bergkvist, Liza
    Linköping University, Faculty of Science & Engineering. Linköping University, Department of Physics, Chemistry and Biology, Chemistry.
    Nath, Sangeeta
    Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Medicine and Health Sciences.
    Kielkopf, Claudia
    Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Medicine and Health Sciences.
    Janefjord, Camilla
    Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences.
    Helmfors, Linda
    Linköping University, Department of Physics, Chemistry and Biology, Chemistry. Linköping University, Faculty of Science & Engineering.
    Zetterberg, Henrik
    Clinical Neurochemistry Laboratory, Department of Neuroscience and Physiology, Sahlgrenska University Hospital, Mölndal, Sweden / UCL Institute of Neurology, London, UK.
    Blennow, Kaj
    Clinical Neurochemistry Laboratory, Department of Neuroscience and Physiology, Sahlgrenska University Hospital, Mölndal, Sweden.
    Li, Hongyun
    Illawarra Health and Medical Research Institute, University of Wollongong, Australia.
    Nilsberth, Camilla
    Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Local Health Care Services in Central Östergötland, Department of Acute Internal Medicine and Geriatrics.
    Garner, Brett
    Illawarra Health and Medical Research Institute, University of Wollongong, Australia / School of Biological Sciences, University of Wollongong, Australia.
    Brorsson, Ann-Christin
    Linköping University, Department of Physics, Chemistry and Biology, Chemistry. Linköping University, Faculty of Science & Engineering.
    Kågedal, Katarina
    Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Medicine and Health Sciences.
    Beneficial effects of increased lysozyme levels in Alzheimer’s disease modelled in Drosophila melanogaster2016In: The FEBS Journal, ISSN 1742-464X, E-ISSN 1742-4658, Vol. 283, no 19, p. 3508-3522Article in journal (Refereed)
    Abstract [en]

    Genetic polymorphisms of immune genes that associate with higher risk to develop Alzheimer’s disease (AD) have led to an increased research interest on the involvement of the immune system in AD pathogenesis. A link between amyloid pathology and immune gene expression was suggested in a genome-wide gene expression study of transgenic amyloid mouse models. In this study, the gene expression of lysozyme, a major player in the innate immune system, was found to be increased in a comparable pattern as the amyloid pathology developed in transgenic mouse models of AD. A similar pattern was seen at protein levels of lysozyme in human AD brain and CSF, but this lysozyme pattern was not seen in a tau transgenic mouse model. Lysozyme was demonstrated to be beneficial for different Drosophila melanogaster models of AD. In flies that expressed Aβ1-42 or AβPP together with BACE1 in the eyes, the rough eye phenotype indicative of toxicity was completely rescued by coexpression of lysozyme. In Drosophila flies bearing the Aβ1-42 variant with the Arctic gene mutation, lysozyme increased the fly survival and decreased locomotor dysfunction dose dependently. An interaction between lysozyme and Aβ1-42 in the Drosophila eye was discovered. We propose that the increased levels of lysozyme, seen in mouse models of AD and in human AD cases, were triggered by Aβ1-42 and caused a beneficial effect by binding of lysozyme to toxic species of Aβ1-42, which prevented these from exerting their toxic effects. These results emphasize the possibility of lysozyme as biomarker and therapeutic target for AD.

  • 4812.
    Sandström, Annelie
    et al.
    aDepartment of Plant Ecology and Evolution, Evolutionary Biology Centre, Uppsala University, Norbyvägen 18D, SE-752 36 Uppsala, Sweden.
    Svensson, Brita M.
    aDepartment of Plant Ecology and Evolution, Evolutionary Biology Centre, Uppsala University, Norbyvägen 18D, SE-752 36 Uppsala, Sweden.
    Milberg, Per
    Linköping University, Department of Physics, Chemistry and Biology, Biology. Linköping University, Faculty of Science & Engineering.
    An example of how to build conservation evidence from case studies:Fire and raking to enhance Pulsatilla vernalis populations2017In: Journal for Nature Conservation, ISSN 1617-1381, E-ISSN 1618-1093, Vol. 36, p. 58-64Article in journal (Refereed)
    Abstract [en]

    tCan data collected by practitioners during practical conservation work be used as decision support? Tofind out, we used unpublished data from attempts to enhance populations of the vascular plant Pulsatillavernalis in Sweden. About half of the 50 located cases had generated data useful for meta-analysis. Wecould show that burning had a positive effect while mechanical disturbance had negligible effects onnumber of plants in short-term follow-ups. Furthermore, we suggest that follow-up variables related toflowering are inferior for monitoring intervention success as flowering varies greatly between years. Inthe broader context, our example shows that simple records from practical conservation work can be arich source of information. It was also obvious that there is great potential for more useful evidence bymaking just small improvements in field protocols, documentation, and archiving. Finally, we suggestthat biologists and researchers need to develop an appreciation of "different levels of evidence", and thatin circumstances where we lack relevant experiments or observational studies, case studies might beuseful for improving interventions.

    The full text will be freely available from 2019-02-10 11:25
  • 4813.
    Sandsveden, Daniel
    Linköping University, Department of Electrical Engineering, Computer Vision. Linköping University, Faculty of Science & Engineering.
    Evaluation of Random Forests for Detection and Localization of Cattle Eyes2015Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    In a time when cattle herds grow continually larger the need for automatic methods to detect diseases is ever increasing. One possible method to discover diseases is to use thermal images and automatic head and eye detectors. In this thesis an eye detector and a head detector is implemented using the Random Forests classifier. During the implementation the classifier is evaluated using three different descriptors: Histogram of Oriented Gradients, Local Binary Patterns, and a descriptor based on pixel differences. An alternative classifier, the Support Vector Machine, is also evaluated for comparison against Random Forests.

    The thesis results show that Histogram of Oriented Gradients performs well as a description of cattle heads, while Local Binary Patterns performs well as a description of cattle eyes. The provided descriptor performs almost equally well in both cases. The results also show that Random Forests performs approximately as good as the Support Vector Machine, when the Support Vector Machine is paired with Local Binary Patterns for both heads and eyes.

    Finally the thesis results indicate that it is easier to detect and locate cattle heads than it is to detect and locate cattle eyes. For eyes, combining a head detector and an eye detector is shown to give a better result than only using an eye detector. In this combination heads are first detected in images, followed by using the eye detector in areas classified as heads.

  • 4814.
    Sandvik, Fredrik
    et al.
    Linköping University, Department of Electrical Engineering, Computer Engineering. Linköping University, Faculty of Science & Engineering.
    Tingstam, Olle
    Linköping University, Department of Electrical Engineering, Computer Engineering. Linköping University, Faculty of Science & Engineering.
    Design and Prototyping of a Scalable Contactor Platform Adapted to State-of-the-Art Functions2015Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    The goal of the thesis is to investigate and propose a new design for a contactor platform, both in terms of hardware and embedded software, which incorporates support to implement new state-of-the-art functions. The platform must support a wide range of contactors from basic ones with only core functions to advanced contactors using modern microcontrollers to provide efficient, quick and reliable operation.

     

    Further, a significant focus of the thesis is on the interaction between electrical engineering and computer engineering. The electronics needs to interact seamlessly with a microcontroller running a versatile software to provide industry-leading performance. To achieve this, the software and hardware is evaluated with focus to develop an optimal platform.

     

    The proposed embedded software uses development techniques rarely used in embedded applications such as UML code generation, compile-time initiation of objects and an object-oriented design, while maintaining the performance of traditional embedded programming. The thesis also provides suggestions to hardware changes to further improve to the contactor’s operation.

  • 4815.
    Sandén, Louise
    et al.
    Linköping University, Department of Management and Engineering, Quality Technology and Management.
    Chowdhury, Tanima
    Linköping University, Department of Management and Engineering, Quality Technology and Management. Linköping University, Faculty of Science & Engineering.
    Analytics for Management: En modell som beskriver framtagandet av ett beslutsunderlag där rätt mätetal visualiseras på rätt sätt utifrån en formulerad strategi2015Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    In existing theory, strategic management and process measurements are commonly treated separately even though the importance of connecting them is also mentioned. However, a comprehensive model or theory that combines strategic management and process measurement fully and describes how the implementation should be done in practice has not been found in literature. Thereby, the aim of the thesis Analytics for Management (AFM) is to develop a model that describes how to develop the right Key Performance Indicators (KPIs) based on corporate strategy and visualize them correctly in order to describe process performance. This results in a decision-making tool that combines strategic management and process measurement to be used by management.

    The model was initially developed through theoretical studies that resulted in a conceptual model. Thereafter, the conceptual model was tested through case studies at three companies with different organizational structure and size. By combining the theories and the results from the field studies the AFM model was finalized.

    The AFM model consists of three phases, where the first phase involves strategy decomposition and goal formulation. This is done by a stepwise decomposition of the strategy through strategic objectives and a strategy map, formulation of critical success factors finally resulting in tactical objectives. In the second phase, KPIs are developed by generating preliminary KPIs based on the tactical goals and then mapping them. KPI mapping is used to distinguish between different types of KPIs resulting in identification of Key Performance Outcomes (KPO) that describe the process performance and Key Performance Drivers (KPD) affecting the outcome that the KPOs represent. The KPDs drive the results of the organization, and should therefore be used for monitoring and controlling the business. When the KPI mapping has been completed the KPIs that will be used for measurement are chosen.

    In the final phase, measurement preparations are done through a data collection plan. Thereafter measurements are performed and compiled in order to visualize KPIs correctly. As the KPOs and KPDs should be used for different purposes they should also be visualized differently. KPOs should be visualized through simple charts in a scorecard that the management should use as a first step for monitoring. Then, in order to find the cause of the KPOs and be able to improve them, a controlcard should be used. The KPDs are compiled in the controlcard through control charts, which show variation in processes, and enables early detection of changes and process control. The AFM model thereby, through the use of a scorecard and a controlcard, results in a decision-making tool where the right KPIs are visualized correctly.

    The results from the field studies and the different characteristics of the companies have proven a high level of generalizability of the model. Furthermore, the AFM model addresses highly important and pressing issues involving strategic management and process measurement, which all types of companies need to consider in daily operations. The AFM model aims to make it easier for organizations to act energetically and proactive through the decision-making tool. In conclusion, the AFM model enables a uniform use of metrics aligned with the strategy, in order to monitor and control process performance.

  • 4816. Sanga, M.
    et al.
    Norén, L.
    Lindsten, H.
    Rådström, P.
    Ansell, Ricky
    Linköping University, Department of Physics, Chemistry and Biology, Biology. Linköping University, Faculty of Science & Engineering.
    Hedman, J.
    A panel of PCR-inhibitory reference materials for quality evaluation of multiplex STR analysis kits: -2015In: Abstracts ISFG, 2015, p. 226-Conference paper (Refereed)
    Abstract [en]

    PCR inhibition is a key challenge in forensic DNA analysis. Substances interfering with the amplification of PCR products can lower the success rate of Short Tandem Repeat (STR) analysis or generate ambiguous DNA profiles.

    For forensic DNA laboratories it is therefore vital to have knowledge about how common inhibitory substances affect their STR analysis system. We have developed a broad-range panel of standardized PCR-inhibitory reference materials (RMs), representing the heterogeneous stains found at crime scenes. The panel, including solutions prepared from for example cigarette paper,

    chewing gum, moist snuff and humic acid, is a tool for quality evaluation of STR systems. We applied the RMs to challenge PowerPlex® ESX 16 Fast System (ESX Fast). Although ESX Fast tolerated high levels of some inhibitors, several RMs caused problems in different ways. Humic acid had a specific negative effect on amelogenin amplification, moist snuff hindered amplification of longer fragments, and chewing gum caused generally lowered allele peak heights. These different effects may provide information regarding the mechanisms of inhibition. For instance, our results indicate that one effect of humic acid on ESX Fast analysis is chelation of Mg2+ ions, thus altering the melting temperatures of the primers. In the developmental validation of STR systems, a limited evaluation of PCR inhibition involving only a few substances is generally performed. Applying a broad panel of RMs will ensure that a wider range of inhibitory substances from crime scene samples are included, giving a better understanding of inhibitor tolerance and effects.

     

  • 4817.
    Sanga, Malin
    et al.
    Swedish National Forensic Centre, Linköping, Sweden.
    Boiso, Lina
    Swedish National Forensic Centre, Linköping, Sweden.
    Lindsten, Harwati
    Swedish National Forensic Centre, Linköping, Sweden.
    Rådström, Peter
    Applied Microbiology, Department of Chemistry, Lund University, Lund, Sweden.
    Ansell, Ricky
    Linköping University, Department of Physics, Chemistry and Biology, Biology. Linköping University, Faculty of Science & Engineering. Swedish National Forensic Centre, Linköping, Sweden.
    Hedman, Johannes
    Swedish National Forensic Centre, Linköping, Sweden; Applied Microbiology, Department of Chemistry, Lund University, Lund, Sweden.
    A panel of PCR-inhibitory reference materials for quality evaluation of multiplex STR analysis kits2015In: Forensic Science International: Genetics Supplement Series, ISSN 1875-1768, E-ISSN 1875-175X, Vol. 5, p. e317-319Article in journal (Refereed)
    Abstract [en]

    PCR inhibition is a critical parameter in forensic DNA analysis. Substances interfering with amplification of short tandem repeats (STRs) may generate partial and/or ambiguous DNA profiles. We present a strategy for developing a broad panel of PCR-inhibitory reference materials (RMs), representing common casework samples. Our panel, including solutions prepared from for example cigarettes, chewing gum and soil, is a tool for in-house validation and lot testing of STR systems. PowerPlex ESX 16 Fast System tolerated high levels of some RMs, but several substances caused amplification problems. Humic acid had a negative effect on amelogenin, moist snuff hindered amplification of longer fragments, and chewing gum caused generally lowered allele peak heights. Applying a broad panel of RMs ensures that a wide range of inhibitory substances are tested, giving an improved understanding of inhibitor tolerance and effects.

  • 4818.
    Sangiovanni, Davide
    Linköping University, Department of Physics, Chemistry and Biology, Theoretical Physics. Linköping University, Faculty of Science & Engineering. Ruhr Univ Bochum, Germany.
    Inherent toughness and fracture mechanisms of refractory transition-metal nitrides via density-functional molecular dynamics2018In: Acta Materialia, ISSN 1359-6454, E-ISSN 1873-2453, Vol. 151, p. 11-20Article in journal (Refereed)
    Abstract [en]

    Hard refractory transition-metal nitrides possess unique combinations of outstanding mechanical and physical properties, but are typically brittle. Recent experimental results demonstrated that single-crystal NaCI-structure (B1) V0.5Mo0.5N pseudobinary solid solutions are both hard (similar to 20 GPa) and ductile; that is, they exhibit toughness, which is unusual for ceramics. However, key atomic-scale mechanisms underlying this inherent toughness are unknown. Here, I carry out density-functional ab initio molecular dynamics (AIMD) simulations at room temperature to identify atomistic processes and associated changes in the electronic structure which control strength, plasticity, and fracture in V0.5Mo0.5N, as well as reference B1 TiN, subject to amp;lt;001amp;gt; and amp;lt;110amp;gt; tensile deformation. AIMD simulations reveal that V0.5Mo0.5N is considerably tougher than TiN owing to its ability to (i) isotropically redistribute mechanical stresses within the elastic regime, (ii) dissipate the accumulated strain energy by activating local structural transformations beyond the yield point. In direct contrast, TiN breaks in brittle manner when applied stresses reach its tensile strength. Charge transfer maps show that the adaptive mechanical response of V0.5Mo0.5N originates from highly populated d-d metallic-states, which allow for counterbalancing the destabilization induced via tensile deformation by enabling formation of new chemical bonds. The high ionic character and electron-localization in TiN precludes the possibility of modifying bonding geometries to accommodate the accumulated stresses, thus suddenly causing materials fracture for relatively low strain values. 

    The full text will be freely available from 2020-03-26 17:47
  • 4819.
    Sangiovanni, Davide Giuseppe
    Linköping University, Department of Physics, Chemistry and Biology, Theoretical Physics. Linköping University, Faculty of Science & Engineering.
    Copper adatom, admolecule transport, and island nucleation on TiN(0 0 1) via ab initio molecular dynamics2018In: Applied Surface Science, ISSN 0169-4332, E-ISSN 1873-5584, Vol. 50, p. 180-189Article in journal (Refereed)
    Abstract [en]

    Density-functional ab initio molecular dynamics (AIMD) simulations are carried out to determine Cu adatom and admolecule transport properties as a function of temperature, as well as atomistic processes leading to formation of Cu/TiN(0 0 1) islands at 350 K. At very low temperatures T ≤ 200 K, Cu adatoms (Cuad) migrate among favored fourfold-hollow surface sites by passing across atop-Ti metastable positions. For increasing temperatures, however, Cuad transport becomes progressively more isotropic, and switches continuously from normal- to super-diffusive with mean-square displacement dependencies on time that alternate between linear and exponential. Despite that, the Cuad diffusivity D can be expressed by a fairly Arrhenius-like behavior D(T) = 8.26(×2±1) × 10−4 cm2 s−1exp[(−0.04 ± 0.01 eV)/(kBT)] over the entire investigated temperature range (100 ≤ T ≤ 1000 K). AIMD simulations also reveal that the condensation of Cu adatoms into Cux>1 adspecies is kinetically hindered by long-range (>5.5 Å) adatom/adatom repulsion. During Cu island nucleation, all Cu atoms occupy atop-N positions indicating favored Cu(0 0 1)/TiN(0 0 1) epitaxial growth. Nevertheless, Cu agglomerates formed by five, or more, atoms tend to arrange in 3D structures, which maximize intracluster bonds while minimizing film/substrate interactions. Results here presented provide insights for understanding the properties of weakly-interacting metal/substrate interface systems in general.

    The full text will be freely available from 2020-04-22 11:26
  • 4820.
    Sangiovanni, Davide
    et al.
    Linköping University, Department of Physics, Chemistry and Biology, Theoretical Physics. Linköping University, Faculty of Science & Engineering.
    Hellman, Olle
    Linköping University, Department of Physics, Chemistry and Biology, Theoretical Physics. Linköping University, Faculty of Science & Engineering.
    Alling, Björn
    Linköping University, Department of Physics, Chemistry and Biology, Thin Film Physics. Linköping University, Faculty of Science & Engineering. Max Planck Institute Eisenforsch GmbH, Germany.
    Abrikosov, Igor
    Linköping University, Department of Physics, Chemistry and Biology, Theoretical Physics. Linköping University, Faculty of Science & Engineering. National University of Science and Technology MISIS, Russia; Tomsk State University, Russia.
    Efficient and accurate determination of lattice-vacancy diffusion coefficients via non equilibrium ab initio molecular dynamics2016In: PHYSICAL REVIEW B, ISSN 2469-9950, Vol. 93, no 9, p. 094305-Article in journal (Refereed)
    Abstract [en]

    We revisit the color-diffusion algorithm [Aeberhard et al., Phys. Rev. Lett. 108, 095901 (2012)] in non equilibrium ab initio molecular dynamics (NE-AIMD) and propose a simple efficient approach for the estimation of monovacancy jump rates in crystalline solids at temperatures well below melting. Color-diffusion applied to monovacancy migration entails that one lattice atom (colored atom) is accelerated toward the neighboring defect site by an external constant force F. Considering bcc molybdenum between 1000 and 2800 K as a model system, NE-AIMD results show that the colored-atom jump rate k(NE) increases exponentially with the force intensity F, up to F values far beyond the linear-fitting regime employed previously. Using a simple model, we derive an analytical expression which reproduces the observed k(NE)(F) dependence on F. Equilibrium rates extrapolated by NE-AIMD results are in excellent agreement with those of unconstrained dynamics. The gain in computational efficiency achieved with our approach increases rapidly with decreasing temperatures and reaches a factor of 4 orders of magnitude at the lowest temperature considered in the present study.

  • 4821.
    Sangiovanni, Davide
    et al.
    Linköping University, Department of Physics, Chemistry and Biology, Theoretical Physics. Linköping University, Faculty of Science & Engineering.
    Hultman, Lars
    Linköping University, Department of Physics, Chemistry and Biology, Thin Film Physics. Linköping University, Faculty of Science & Engineering.
    Chirita, Valeriu
    Linköping University, Department of Physics, Chemistry and Biology, Thin Film Physics. Linköping University, Faculty of Science & Engineering.
    Petrov, Ivan
    Linköping University, Department of Physics, Chemistry and Biology, Thin Film Physics. Linköping University, Faculty of Science & Engineering. University of Illinois, USA.
    Greene, Joseph E
    Linköping University, Department of Physics, Chemistry and Biology, Thin Film Physics. Linköping University, Faculty of Science & Engineering. University of Illinois, USA.
    Effects of phase stability, lattice ordering, and electron density on plastic deformation in cubic TiWN pseudobinary transition-metal nitride alloys2016In: Acta Materialia, ISSN 1359-6454, E-ISSN 1873-2453, Vol. 103, p. 823-835Article in journal (Refereed)
    Abstract [en]

    We carry out density functional theory calculations to compare the energetics of layer glide, as well as stress vs. strain curves, for cubic Ti0.5W0.5N pseudobinary alloys and reference B1-structure TiN. Irrespective of the degree of ordering on the metal sublattice, the hardness and stiffness of Ti0.5W0.5, as estimated by stress strain results and resistance to layer glide, are comparable to that of the parent binary TiN, while ductility is considerably enhanced. After an initial elastic response to an applied load, the pseudobinary alloy deforms plastically, thus releasing accumulated mechanical stress. In contrast, stress continues to increase linearly with strain in TiN. Layer glide in Ti0.5W0.5N is promoted by a high valence-electron concentration which enables the formation of strong metallic bonds within the slip direction upon deformation. [1111-oriented Ti0.5W0.5N layers characterized by high local metal-sublattice ordering exhibit low resistance to slip along < 110 > directions due to energetically favored formation of (111) hexagonal stacking faults. This is consistent with the positive formation energy of < 111 >-ordered Tio.5W0.5N with respect to mixing of cubic-BI TiN and hexagonal WC-structure WN. In the cubic pseudobinary alloy, slip occurs parallel, as well as orthogonal, to the resolved applied stress at the interface between layers with the lowest friction. We suggest that analogous structural metastability (mixing cubic and hexagonal TM nitride binary phases) and electronic (high valence electron concentration) effects are responsible for the enhanced toughness recently demonstrated experimentally for cubic single-crystal pseudobinary V0.5W0.5N and V0.5MocoN epitaxial layers. (c) 2015 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

  • 4822.
    Sangiovanni, Davide
    et al.
    Linköping University, Department of Physics, Chemistry and Biology, Theoretical Physics. Linköping University, Faculty of Science & Engineering. Ruhr University of Bochum, Germany.
    Mei, A. B.
    University of Illinois, IL 61801 USA; Cornell University, NY 14853 USA.
    Edström, Daniel
    Linköping University, Department of Physics, Chemistry and Biology, Thin Film Physics. Linköping University, Faculty of Science & Engineering.
    Hultman, Lars
    Linköping University, Department of Physics, Chemistry and Biology, Thin Film Physics. Linköping University, Faculty of Science & Engineering.
    Chirita, Valeriu
    Linköping University, Department of Physics, Chemistry and Biology, Thin Film Physics. Linköping University, Faculty of Science & Engineering.
    Petrov, Ivan
    Linköping University, Department of Physics, Chemistry and Biology, Thin Film Physics. Linköping University, Faculty of Science & Engineering. University of Illinois, USA.
    Greene, Joseph E
    Linköping University, Department of Physics, Chemistry and Biology, Thin Film Physics. Linköping University, Faculty of Science & Engineering. University of Illinois, USA.
    Effects of surface vibrations on interlayer mass transport: Ab initio molecular dynamics investigation of Ti adatom descent pathways and rates from TiN/TiN(001) islands2018In: Physical Review B, ISSN 2469-9950, E-ISSN 2469-9969, Vol. 97, no 3, article id 035406Article in journal (Refereed)
    Abstract [en]

    We carried out density-functional ab initio molecular dynamics (AIMD) simulations of Ti adatom (Ti-ad ) migration on, and descent from, square TiN(100) epitaxial islands on TiN(001) at temperatures (T) ranging from 1200 to 2400 K. Adatom-descent energy barriers determined via ab initio nudged-elastic-band calculations at 0 Kelvin suggest that Ti interlayer transport on TiN(001) occurs essentially exclusively via direct hopping onto a lower layer. However, AIMD simulations reveal comparable rates for Ti-ad descent via direct hopping vs push-out/exchange with a Ti island-edge atom for T amp;gt;= 1500 K. We demonstrate that this effect is due to surface vibrations, which yield considerably lower activation energies at finite temperatures by significantly modifying the adatom push-out/exchange reaction pathway.

  • 4823.
    Sangiovanni, Davide
    et al.
    Linköping University, Department of Physics, Chemistry and Biology, Theoretical Physics. Linköping University, Faculty of Science & Engineering.
    Mei, A. B.
    University of Illinois, IL 61801 USA.
    Hultman, Lars
    Linköping University, Department of Physics, Chemistry and Biology, Thin Film Physics. Linköping University, Faculty of Science & Engineering.
    Chirita, Valeriu
    Linköping University, Department of Physics, Chemistry and Biology, Thin Film Physics. Linköping University, Faculty of Science & Engineering.
    Petrov, Ivan
    Linköping University, Department of Physics, Chemistry and Biology, Thin Film Physics. Linköping University, Faculty of Science & Engineering. University of Illinois, IL 61801 USA.
    Greene, Joseph E
    Linköping University, Department of Physics, Chemistry and Biology, Thin Film Physics. Linköping University, Faculty of Science & Engineering. University of Illinois, IL 61801 USA; University of Illinois, IL 61801 USA.
    Ab Initio Molecular Dynamics Simulations of Nitrogen/VN(001) Surface Reactions: Vacancy-Catalyzed N-2 Dissociative Chemisorption, N Adatom Migration, and N-2 Desorption2016In: The Journal of Physical Chemistry C, ISSN 1932-7447, E-ISSN 1932-7455, Vol. 120, no 23, p. 12503-12516Article in journal (Refereed)
    Abstract [en]

    We use density-functional ab initio molecular dynamics to investigate the kinetics of N/VN(001) surface reactions at temperatures ranging from 1600 to 2300 K. N adatoms (N-ad) on VN(001) favor epitaxial atop-V positions and diffuse among them by transiting through 4-fold hollow (FFH) sites, at which they are surrounded by two V and two N surface atoms. After several atop-V -amp;gt; FFH -amp;gt; atop-V jumps, isolated N adatoms bond strongly with an underlying N surface (N-surf) atom. Frequent N-ad/N-surf pair exchange reactions lead to N-2 desorption, which results in the formation of an anion surface vacancy. N vacancies rapidly migrate via in-plane (110) jumps and act as efficient catalysts for the dissociative chemisorption of incident N-2 molecules. During exposure of VN(001) to incident atomic N gas atoms, N-ad/N-ad recombination and desorption is never observed, despite a continuously high N monomer surface coverage. Instead, N-2 desorption is always initiated by a N adatom removing a N surface atom or by energetic N gas atoms colliding with N-ad or N-surf atoms. Similarities and differences between: N/VN(001) vs. previous N/TiN(001) results, discussed on the basis of temperature-dependent ab initio electronic structures and chemical bonding, provide insights for controlling the reactivity of NaCl-structure transition-metal nitride (001) surfaces via electron-concentration tuning.

  • 4824.
    Sangiovanni, Davide
    et al.
    Linköping University, Department of Physics, Chemistry and Biology, Theoretical Physics. Linköping University, Faculty of Science & Engineering.
    Tasnadi, Ferenc
    Linköping University, Department of Physics, Chemistry and Biology, Theoretical Physics. Linköping University, Faculty of Science & Engineering.
    Hultman, Lars
    Linköping University, Department of Physics, Chemistry and Biology, Thin Film Physics. Linköping University, Faculty of Science & Engineering.
    Petrov, Ivan
    Linköping University, Department of Physics, Chemistry and Biology, Thin Film Physics. Linköping University, Faculty of Science & Engineering. University of Illinois, USA.
    Greene, Joseph E
    Linköping University, Department of Physics, Chemistry and Biology, Thin Film Physics. Linköping University, Faculty of Science & Engineering. University of Illinois, USA.
    Chirita, Valeriu
    Linköping University, Department of Physics, Chemistry and Biology, Thin Film Physics. Linköping University, Faculty of Science & Engineering.
    N and Ti adatom dynamics on stoichiometric polar TiN(111) surfaces2016In: Surface Science, ISSN 0039-6028, E-ISSN 1879-2758, Vol. 649, p. 72-79Article in journal (Refereed)
    Abstract [en]

    We use molecular dynamics (MD) based on the modified embedded atom method (MEAM) to determine diffusion coefficients and migration pathways for Ti and N adatoms (Ti-ad and N-ad) on TiN(111). The reliability of the classical model-potential is verified by comparison with density functional theory (DFT) results at 0 K. MD simulations carried out at temperatures between 600 and 1800 K show that both Ti-ad and N-ad favor fcc surface sites and migrate among them by passing through metastable hcp positions. We find that N-ad species are considerably more mobile than Ti-ad on TiN(111); contrary to our previous results on TiN(001). In addition, we show that lattice vibrations at finite temperatures strongly modify the potential energy landscape and result in smaller adatom migration energies, E-a = 1.03 for Ti-ad and 0.61 eV for N-ad, compared to 0 K values E-aOK = 1.55 (Ti-ad) and 0.79 eV (N-ad). We also demonstrate that the inclusion of dipole corrections, neglected in previous DFT calculations, is necessary in order to obtain the correct formation energies for polar surfaces such as TiN(111). (C) 2016 Elsevier B.V. All rights reserved.

  • 4825.
    Sani, Negar
    Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, Faculty of Science & Engineering.
    Addressability and GHz Operation in Flexible Electronics2016Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The discovery of conductive polymers in 1977 opened up a whole new path for flexible electronics. Conducting polymers and organic semiconductors are carbon rich compounds that are able to conduct charges while flexed and are compatible with low-cost and large-scale processes including printing and coating techniques. The conducting polymer has aided the rapidly expanding field of flexible electronics, leading to many new applications such as electronic skin, RFID tags, smart labels, flexible displays, implantable medical devices, and flexible sensors.

    However, there are several remaining challenges in the production and implementation of flexible electronic materials and devices. The  conductivity of organic conductors and semiconductors is still orders of magnitude lower compared to their inorganic counterparts. In addition, non-flexible inorganic semiconductors still remain the materials of choice for high frequency applications; since the charge carrier mobility and thus operational speed of the organic materials are limited. Therefore, there remains a high demand to combine the high frequency operation of inorganic semiconductors with the flexible fabrication methods of organic systems for future electronics.

    In addition to the challenges in the choice of materials in flexible electronics, the upscaling of the flexible devices and implementing them in circuits can also be complicated. Lack of non-linearity is an issue that arises when flexible devices with linear behavior need to be incorporated in an array or matrix form. Non-linearity is important for applications such as displays and memory arrays, where the devices are arranged as matrix cells addressed by their row and column number. If the behavior of cells in the matrix is linear, addressing each cell affects the adjacent cells. Therefore, inducing non-linearity and, consequently, addressability in such linear devices is the first step before scaling up into matrix schemes.

    In this work, non-linear organic/inorganic hybrid devices are produced to overcome the limitations mentioned above and leverage the advantages of both organic and inorganic materials. Two novel methods are developed to incorporate non-flexible inorganic semiconductors into ultra-high frequency (UHF) flexible devices. In the first method, Si is ground into a powder with micrometer-sized particles and printed through standard screen printing. For the first time, allprinted flexible diodes operating in the GHz range are produced. The energy harvesting application of the printed diodes is demonstrated in a flexible circuit coupling an antenna and the display to the diode.

    A second and simpler room-temperature method based on lamination was later developed, which further improves device performance and operational frequency. For the first time, a flexible semiconducting composite film consisting of Si micro-particles, glycerol, and nano-fibrillated cellulose is produced and used as the semiconducting layer of the UHF diode.

    The diodes fabricated through both mentioned processes are demonstrated in energy harvesting applications in the GHz range; however, they can also serve as rectifiers or non-linear elements in any other flexible and UHF circuit.

    Furthermore, a new approach is developed to induce non-linearity and hence addressability in linear devices in order to make their implementation in flexible matrix form feasible. This is accomplished by depositing a ferroelectric layer on a device electrode and thus controlling charge transfer through the electrode. The electrode current becomes limited to the charge displacement current established in the ferroelectric layer during polarization. Thus, the current does not follow the voltage linearly and non-linearity is induced in the device. The polarization voltage is dictated by the thickness of the ferroelectric layer. Therefore, the switching voltage of the device can be tuned by adjusting the ferroelectric layer thickness. In this work, the organic ferroelectric poly(vinylidene fluoride-co-trifluoroethylene) (P(VDF-TrFE)) is used due to its distinctive properties such as stability, high polarizability and simple processability. The polarization of P(VDF-TrFE) through an electrolyte and an electrophoretic liquid is investigated. In addition, a simple model is presented in order to understand the field and potential distribution, and the ferroelectric polarization, in the P(VDF-TrFE)-electrolyte contact. The induction of non-linearity through P(VDF-TrFE) is successfully demonstrated in novel addressable and bistable devices and memory elements such as non-linear electrophoretic display cells, organic ferroelectrochromic displays (FeOECDs), and ferroelectrochemical organic transistors (FeOECTs).

  • 4826.
    Sankoh, Supannee
    et al.
    Linköping University, Department of Physics, Chemistry and Biology, Biosensors and Bioelectronics. Linköping University, Faculty of Science & Engineering. Prince Songkla University, Thailand.
    Vagin, Mikhail
    Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, Faculty of Science & Engineering.
    Sekretareva, Alina
    Linköping University, Faculty of Science & Engineering. Linköping University, Department of Physics, Chemistry and Biology, Biosensors and Bioelectronics. Stanford University, CA 94305 USA.
    Thavarungkul, Panote
    Prince Songkla University, Thailand.
    Kanatharana, Proespichaya
    Prince Songkla University, Thailand.
    Mak, Wing Cheung
    Linköping University, Department of Physics, Chemistry and Biology, Biosensors and Bioelectronics. Linköping University, Faculty of Science & Engineering.
    Colloid electrochemistry of conducting polymer: towards potential-induced in-situ drug release2017In: Electrochimica Acta, ISSN 0013-4686, E-ISSN 1873-3859, Vol. 228, p. 407-412Article in journal (Refereed)
    Abstract [en]

    Over the past decades, controlled drug delivery system remains as one of the most important area in medicine for various diseases. We have developed a new electrochemically controlled drug release system by combining colloid electrochemistry and electro-responsive microcapsules. The pulsed electrode potential modulation led to the appearance of two processes available for the time-resolved registration in colloid microenvironment: change of the electronic charge of microparticles (from 0.5 ms to 0.1 s) followed by the drug release associated with ionic equilibration (1-10 s). The dynamic electrochemical measurements allow the distinction of drug release associated With ionic relaxation and the change of electronic charge of conducting polymer colloid microparticles. The amount of released drug (methylene blue) could be controlled by modulating the applied potential. Our study demonstrated a surface-potential driven controlled drug release of dispersion of conducting polymer carrier at the electrode interfaces, while the bulk colloids dispersion away from the electrode remains as a reservoir to improve the efficiency of localized drug release. The developed new methodology creates a model platform for the investigations of surface potential-induced in-situ electrochemical drug release mechanism. (C) 2017 Elsevier Ltd. All rights reserved.

    The full text will be freely available from 2019-01-08 11:51
  • 4827.
    Santangelo, M. F.
    et al.
    CNR, Italy.
    Libertino, S.
    CNR, Italy.
    Turner, Anthony
    Linköping University, Department of Physics, Chemistry and Biology, Sensor and Actuator Systems. Linköping University, Faculty of Science & Engineering.
    Filippini, Daniel
    Linköping University, Department of Physics, Chemistry and Biology, Sensor and Actuator Systems. Linköping University, Faculty of Science & Engineering.
    Mak, Wing Cheung
    Linköping University, Department of Physics, Chemistry and Biology, Sensor and Actuator Systems. Linköping University, Faculty of Science & Engineering.
    Integrating printed microfluidics with silicon photomultipliers for miniaturised and highly sensitive ATP bioluminescence detection2018In: Biosensors & bioelectronics, ISSN 0956-5663, E-ISSN 1873-4235, Vol. 99, p. 464-470Article in journal (Refereed)
    Abstract [en]

    Bioluminescence has been widely used for important biosensing applications such as the measurement of adenosine triphosphate (ATP), the energy unit in biological systems and an indicator of vital processes. The current technology for detection is mainly based on large equipment such as readers and imaging systems, which require intensive and time-consuming procedures. A miniaturised bioluminescence sensing system, which would allow sensitive and continuous monitoring of ATP, with an integrated and low-cost disposable microfluidic chamber for handling of biological samples, is highly desirable. Here, we report the design, fabrication and testing of 3D printed microfluidics chips coupled with silicon photomultipliers (SiPMs) for high sensitive real-time ATP detection. The 3D microfluidic chip reduces reactant consumption and facilitates solution delivery close to the SiPM to increase the detection efficiency. Our system detects ATP with a limit of detection (LoD) of 8 nM and an analytical dynamic range between 15 nM and 1 mu M, showing a stability error of 3%, and a reproducibility error below of 20%. We demonstrate the dynamic monitoring of ATP in a continuous flow system exhibiting a fast response time, similar to 4 s, and a full recovery to the baseline level within 17 s. Moreover, the SiPM-based bioluminescence sensing system shows a similar analytical dynamic range for ATP detection to that of a full-size PerkinElmer laboratory luminescence reader.

    The full text will be freely available from 2019-07-27 14:51
  • 4828.
    Santini, Marina
    et al.
    RISE SICS East Linköping, Sweden.
    Jönsson, Arne
    Linköping University, Department of Computer and Information Science, Human-Centered systems. Linköping University, Faculty of Arts and Sciences. RISE SICS East Linköping, Sweden.
    Nyström, Mikael
    Linköping University, Department of Biomedical Engineering. Linköping University, Faculty of Science & Engineering.
    Alireza, Marjan
    Örebro University, Örebro, Sweden.
    A Web Corpus for eCare: Collection, Lay Annotation and Learning - First Results2017Conference paper (Refereed)
    Abstract [en]

    In this position paper, we put forward two claims: 1) it is possible to design a dynamic and extensible corpus without running the risk of getting into scalability problems; 2) it is possible to devise noise-resistant Language Technology applications without affecting performance. To support our claims, we describe the design, construction and limitations of a very specialized medical web corpus, called eCare_Sv_01, and we present two experiments on lay-specialized text classification. eCare_Sv_01 is a small corpus of web documents written in Swedish. The corpus contains documents about chronic diseases. The sublanguage used in each document has been labelled as “lay” or “specialized” by a lay annotator. The corpus is designed as a flexible text resource, where additional medical documents will be appended over time. Experiments show that the lay-specialized labels assigned by the lay annotator are reliably learned by standard classifiers. More specifically, Experiment 1 shows that scalability is not an issue when increasing the size of the datasets to be learned from 156 up to 801 documents. Experiment 2 shows that lay-specialized labels can be learned regardless of the large amount of disturbing factors, such as machine translated documents or low-quality texts that are numerous in the corpus

  • 4829.
    Santos, Javier
    et al.
    Linköping University, Department of Computer and Information Science. Linköping University, Faculty of Science & Engineering.
    Nadjm-Tehrani, Simin
    Linköping University, Department of Computer and Information Science, Software and Systems. Linköping University, Faculty of Science & Engineering.
    Prem Bianzino, Aruna
    Linköping University, Department of Computer and Information Science, Software and Systems. Linköping University, The Institute of Technology.
    Monkey Gamer: Automatic profiling of Android games2014In: International Conference on Mobile Computing, Applications and Services (MobiCASE), IEEE conference proceedings, 2014, p. 1-8Conference paper (Refereed)
    Abstract [en]

    Creation of smartphone applications has undergone a massive explosion in recent years and there is an urgent need for evaluation of their resource efficiency, trustworthiness and reliability. A large proportion of these apps are going to be within the gaming area. In this paper we classify game apps on the basis of their development process, their I/O process and their interaction level. We present Monkey Gamer, a software to automatically play a large class of Android games and collect execution traces, based on a state machine to partially describe the game structure and interactions. A significant similarity is shown when comparing the results obtained by the Monkey Gamer and by human players, for three of the most popular Android games. We evaluate the performance of the Monkey Gamer by comparing the traces it generates with traces created when humans play the games, and find significant similarity in the trace sets.

  • 4830.
    Santos, Tiago
    et al.
    UNINOVA Institute, Portugal.
    Ribeiro, Luis
    Linköping University, Department of Management and Engineering, Manufacturing Engineering. Linköping University, Faculty of Science & Engineering.
    Dionisio Rocha, Andre
    UNINOVA Institute, Portugal.
    Barata, Jose
    UNINOVA Institute, Portugal.
    A system reconfiguration architecture for hybrid automation systems based in agents and programmable logic controllers2016In: 2016 IEEE 14TH INTERNATIONAL CONFERENCE ON INDUSTRIAL INFORMATICS (INDIN), IEEE , 2016, p. 98-103Conference paper (Refereed)
    Abstract [en]

    As web related technologies continue to find their way into production related activities, their true potential can only be explored with a shop floor that is cyber-physically agile. This means the ability to quickly reconfigure a production system during production changeovers while significantly reducing setup times and non value-adding activities keeping the overall performance of the control system. Currently, system reconfiguration in mainly supported by reprogramming. However, reprogramming of large complex systems is often a time consuming and risky activity since it has a non negligible potential for introducing errors which normally result in long debugging times. In this context, this paper details an agent-based system architecture that enables quick system reconfiguration and minimizes the reprogramming effort. For this purpose a production system is abstracted as a multiagent system that dynamically interacts with a native, programmable-logic-controller-based control system and is able to re-parametrize it. The focus on re-parametrization means that the native system can still operate in the absence of the agent system which improves the overall robustness of the solution, using readily available equipment and enables its integration with legacy systems.

  • 4831.
    Sarakinos, Kostas
    et al.
    Linköping University, Department of Physics, Chemistry and Biology, Nanoscale engineering. Linköping University, Faculty of Science & Engineering.
    Greczynski, Grzegorz
    Linköping University, Department of Physics, Chemistry and Biology, Thin Film Physics. Linköping University, Faculty of Science & Engineering.
    Elofsson, Viktor
    Linköping University, Department of Physics, Chemistry and Biology, Nanoscale engineering. Linköping University, Faculty of Science & Engineering.
    Magnfält, Daniel
    Linköping University, Department of Physics, Chemistry and Biology. Linköping University, Faculty of Science & Engineering.
    Högberg, Hans
    Linköping University, Department of Physics, Chemistry and Biology, Thin Film Physics. Linköping University, Faculty of Science & Engineering.
    Alling, Björn
    Linköping University, Department of Physics, Chemistry and Biology, Thin Film Physics. Linköping University, Faculty of Science & Engineering. Max Planck Institute Eisenforsch GmbH, Germany.
    Theoretical and experimental study of metastable solid solutions and phase stability within the immiscible Ag-Mo binary system2016In: Journal of Applied Physics, ISSN 0021-8979, E-ISSN 1089-7550, Vol. 119, no 9, p. 095303-Article in journal (Refereed)
    Abstract [en]

    Metastable solid solutions are phases that are synthesized far from thermodynamic equilibrium and offer a versatile route to design materials with tailor-made functionalities. One of the most investigated classes of metastable solid solutions with widespread technological implications is vapor deposited ternary transition metal ceramic thin films (i.e., nitrides, carbides, and borides). The vapor-based synthesis of these ceramic phases involves complex and difficult to control chemical interactions of the vapor species with the growing film surface, which often makes the fundamental understanding of the composition-properties relations a challenging task. Hence, in the present study, we investigate the phase stability within an immiscible binary thin film system that offers a simpler synthesis chemistry, i.e., the Ag-Mo system. We employ magnetron co-sputtering to grow Ag1-xMox thin films over the entire composition range along with x-ray probes to investigate the films structure and bonding properties. Concurrently, we use density functional theory calculations to predict phase stability and determine the effect of chemical composition on the lattice volume and the electronic properties of Ag-Mo solid solutions. Our combined theoretical and experimental data show that Mo-rich films (x >= similar to 0.54) form bcc Mo-Ag metastable solid solutions. Furthermore, for Ag-rich compositions (x <= similar to 0.21), our data can be interpreted as Mo not being dissolved in the Ag fcc lattice. All in all, our data show an asymmetry with regards to the mutual solubility of Ag and Mo in the two crystal structures, i.e., Ag has a larger propensity for dissolving in the bcc-Mo lattice as compared to Mo in the fcc-Ag lattice. We explain these findings in light of isostructural short-range clustering that induces energy difference between the two (fcc and bcc) metastable phases. We also suggest that the phase stability can be explained by the larger atomic mobility of Ag atoms as compared to that of Mo. The mechanisms suggested herein may be of relevance for explaining phase stability data in a number of metastable alloys, such as ternary transition metal-aluminum-nitride systems. (C) 2016 AIP Publishing LLC.

  • 4832.
    Sarrafchi, Amir
    et al.
    Linköping University, Department of Physics, Chemistry and Biology, Biology. Linköping University, Faculty of Science & Engineering.
    Laska, Matthias
    Linköping University, Department of Physics, Chemistry and Biology, Biology. Linköping University, Faculty of Science & Engineering.
    Olfactory Sensitivity for the Mammalian Blood Odor Component Trans-4,5-epoxy-(E)-2-decenal in CD-1 Mice.2017In: Perception, ISSN 0301-0066, E-ISSN 1468-4233, Vol. 46, no 3-4, p. 333-342Article in journal (Refereed)
    Abstract [en]

    Using a conditioning paradigm and an automated olfactometer, we investigated the olfactory sensitivity of CD-1 mice for the mammalian blood odor component trans-4,5-epoxy-(E)-2-decenal. We found that two of the animals significantly discriminated concentrations down to 3.0 ppt (parts per trillion) from the solvent, and three animals even successfully detected dilutions as low as 0.3 ppt. Intraspecific comparisons between the olfactory detection thresholds obtained here with those obtained in earlier studies with other odorants show that mice are extraordinarily sensitive to this blood odor component. Interspecific comparisons of olfactory detection thresholds show that human subjects are even more sensitive to trans-4,5-epoxy-(E)-2-decenal than the mice tested here. Both intra- and inter-specific comparisons suggest that neither neuroanatomical properties such as the size of the olfactory epithelium, the total number of olfactory receptor neurons, or the size of olfactory brain structures, nor genetic properties such as the number of functional olfactory receptor genes or the proportion of functional relative to the total number of olfactory receptor genes allow us to reliably predict a species' olfactory sensitivity. In contrast, the results support the notion that the behavioral relevance of an odorant rather than neuroanatomical or genetic properties may determine a species' olfactory sensitivity.

  • 4833.
    Sarri, Gianluca
    et al.
    Queen's University Belfast, BT7 1NN, Belfast, United Kingdom.
    Dieckmann, Mark Eric
    Linköping University, Department of Science and Technology, Media and Information Technology. Linköping University, Faculty of Science & Engineering.
    Kourakis, Ioannis
    Queen's University Belfast, BT7 1NN, Belfast, United Kingdom.
    Di Piazza, Antonio
    Max Planck Institute for Nuclear Physics, Heidelberg, Germany.
    Reville, Brian
    Queen's University Belfast, BT7 1NN, Belfast, United Kingdom.
    Keitel, Christian
    Max-Planck-Institut für Kernphysik, Saupfercheckweg 1, 69117 Heidelberg, Germany .
    Zepf, Matt
    Queen's University Belfast, BT7 1NN, Belfast, United Kingdom.
    Overview of laser-driven generation of electron–positron beams2015In: Journal of Plasma Physics, ISSN 0022-3778, E-ISSN 1469-7807, Vol. 81, no 04, p. 1-14, article id 455810401Article in journal (Refereed)
    Abstract [en]

    Electron–positron (e–p) plasmas are widely thought to be emitted, in the form of ultra-relativistic winds or collimated jets, by some of the most energetic or powerful objects in the Universe, such as black-holes, pulsars, and quasars. These phenomena represent an unmatched astrophysical laboratory to test physics at its limit and, given their immense distance from Earth (some even farther than several billion light years), they also provide a unique window on the very early stages of our Universe. However, due to such gigantic distances, their properties are only inferred from the indirect interpretation of their radiative signatures and from matching numerical models: their generation mechanism and dynamics still pose complicated enigmas to the scientific community. Small-scale reproductions in the laboratory would represent a fundamental step towards a deeper understanding of this exotic state of matter. Here we present recent experimental results concerning the laser-driven production of ultra-relativistic e–p beams. In particular, we focus on the possibility of generating beams that present charge neutrality and that allow for collective effects in their dynamics, necessary ingredients for the testing pair-plasma physics in the laboratory. A brief discussion of the analytical and numerical modelling of the dynamics of these plasmas is also presented in order to provide a summary of the novel plasma physics that can be accessed with these objects. Finally, general considerations on the scalability of laboratory plasmas up to astrophysical scenarios are given.

  • 4834.
    Satti Nour, Eiman
    Linköping University, Department of Science and Technology. Linköping University, Faculty of Science & Engineering.
    Development of Zinc Oxide Piezoelectric Nanogenerators for Low Frequency Applications2016Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Energy harvesting using piezoelectric nanomaterials provides an opportunity for advancement towards self-powered systems. Self-powered systems are a new emerging technology, which allows the use of a system or a device that perform a function without the need for external power source like for example, a battery or any other type of source. This technology can for example use harvested energy from sources around us such as ambient mechanical vibrations, noise, and human movement, etc. and convert it to electric energy using the piezoelectric effect. For nanoscale devices, the size of traditional batteries is not suitable and will lead to loss of the concept of “nano”. This is due to the large size and the relatively large magnitude of the delivered power from traditional sources. The development of a nanogenerator (NG) to convert energy from the environment into electric energy would facilitate the development of some self-powered systems relying on nano- devices.

    The main objective of this thesis is to fabricate a piezoelectric Zinc Oxide (ZnO) NGs for low frequency (˂ 100 Hz) energy harvesting applications. For that, different types of NGs based on ZnO nanostructures have been carefully developed, and studied for testing under different kinds of low frequency mechanical deformations. Well aligned ZnO nanowires (NWs) possessing high piezoelectric coefficient were synthesized on flexible substrates using the low temperature hydrothermal route. These ZnO NWs were then used in different configurations to demonstrate different low frequency energy harvesting devices.

    Using piezoelectric ZnO NWs, we started with the fabrication of sandwiched NG for hand writing enabled energy harvesting device based on a thin silver layer coated paper substrate. Such device configurations can be used for the development of electronic programmable smart paper. Further, we developed this NG to work as a triggered sensor for wireless system using foot-step pressure. These studies demonstrate the feasibility of using ZnO NWs piezoelectric NG as a low-frequency self-powered sensor, with potential applications in wireless sensor networks. After that, we investigated and fabricated a sensor on PEDOT: PSS plastic substrate either by one side growth technique or by using double sided growth. For the first growth technique, the fabricated NG has been used as a sensor for acceleration system; while the fabricated NG by the second technique has worked as anisotropic directional sensor. This fabricated configurations showed stability for sensing and can be used in surveillance, security, and auto-mobil applications. In addition to that, we investigated the fabrication of a sandwiched NG on plastic substrates. Finally, we demonstrated that doping ZnO NWs with extrinsic element (such as Ag) will lead to the reduction of the piezoelectric effect due to the loss of crystal symmetry. A brief summary into future opportunities and challenges are also presented in the last chapter of this thesis.

  • 4835.
    Savas, Berkant
    et al.
    Linköping University, Department of Science and Technology, Communications and Transport Systems. Linköping University, Faculty of Science & Engineering.
    Dhillon, Inderjit S.
    University of Texas Austin, USA.
    CLUSTERED MATRIX APPROXIMATION2016In: SIAM Journal on Matrix Analysis and Applications, ISSN 0895-4798, E-ISSN 1095-7162, Vol. 37, no 4, p. 1531-1555Article in journal (Refereed)
    Abstract [en]

    In this paper we develop a novel clustered matrix approximation framework, first showing the motivation behind our research. The proposed methods are particularly well suited for problems with large scale sparse matrices that represent graphs and/or bipartite graphs from information science applications. Our framework and resulting approximations have a number of benefits: (1) the approximations preserve important structure that is present in the original matrix; (2) the approximations contain both global-scale and local-scale information; (3) the procedure is efficient both in computational speed and memory usage; and (4) the resulting approximations are considerably more accurate with less memory usage than truncated SVD approximations, which are optimal with respect to rank. The framework is also quite flexible as it may be modified in various ways to fit the needs of a particular application. In the paper we also derive a probabilistic approach that uses randomness to compute a clustered matrix approximation within the developed framework. We further prove deterministic and probabilistic bounds of the resulting approximation error. Finally, in a series of experiments we evaluate, analyze, and discuss various aspects of the proposed framework. In particular, all the benefits we claim for the clustered matrix approximation are clearly illustrated using real-world and large scale data.

  • 4836.
    Savic, Vladimir
    et al.
    Linköping University, Department of Electrical Engineering, Communication Systems. Linköping University, Faculty of Science & Engineering.
    Larsson, Erik G.
    Linköping University, Department of Electrical Engineering, Communication Systems. Linköping University, Faculty of Science & Engineering.
    Experimental Study of Indoor Tracking Using UWB Measurements and Particle Filtering2016In: 2016 IEEE 17TH INTERNATIONAL WORKSHOP ON SIGNAL PROCESSING ADVANCES IN WIRELESS COMMUNICATIONS (SPAWC), IEEE , 2016Conference paper (Refereed)
    Abstract [en]

    Target tracking with ultra-wideband (UWB) signals in indoor environments is a challenging problem due to the presence of multipath and non-line-of-sight conditions (NLOS). A solution to this problem is to use particle filtering (PF), which is able to handle both nonlinear models and non-Gaussian uncertainties that typically appear in the presence of NLOS. In this paper, we compare four different PF variants, that differ in terms of how  NLOS measurements are handled. According to our experimental results, based on the measurements from a basement tunnel,    multiple features from the UWB impulse response should be used, and  the ranging likelihood function should make use of both LOS and NLOS measurements. Standard time-of-arrival (TOA) based methods, even with NLOS rejection, are not good enough. Instead we advocate TOA-based algorithms that can actively mitigate errors due to NLOS.

  • 4837.
    Savic, Vladimir
    et al.
    Linköping University, Department of Electrical Engineering, Communication Systems. Linköping University, Faculty of Science & Engineering.
    Larsson, Erik G.
    Linköping University, Department of Electrical Engineering, Communication Systems. Linköping University, Faculty of Science & Engineering.
    Fingerprinting-Based Positioning in Distributed Massive MIMO Systems2015In: Proc. of IEEE 82nd Vehicular Technology Conference (VTC2015-Fall), Sept. 2015., Institute of Electrical and Electronics Engineers (IEEE), 2015Conference paper (Refereed)
    Abstract [en]

    Location awareness in wireless networks may enable many applications such as emergency services, autonomous driving and geographic routing. Although there are many available positioning techniques, none of them is adapted to work with massive multiple-in-multiple-out (MIMO) systems, which represent a leading 5G technology candidate. In this paper, we discuss possible solutions for positioning of mobile stations using a vector of signals at the base station, equipped with many antennas distributed over deployment area. Our main proposal is to use fingerprinting techniques based on a vector of received signal strengths. This kind of methods are able to work in highly-cluttered multipath environments, and require just one base station, in contrast to standard range-based and angle-based techniques. We also provide a solution for fingerprinting-based positioning based on Gaussian process regression, and discuss main applications and challenges.

  • 4838.
    Savic, Vladimir
    et al.
    Linköping University, Department of Electrical Engineering, Communication Systems. Linköping University, Faculty of Science & Engineering.
    Larsson, Erik G.
    Linköping University, Department of Electrical Engineering, Communication Systems. Linköping University, Faculty of Science & Engineering.
    Ferrer-Coll, Javier
    University of Gavle, Sweden.
    Stenumgaard, Peter
    Linköping University, Department of Electrical Engineering, Communication Systems. Linköping University, Faculty of Science & Engineering. Swedish Defense Research Agency (FOI), Linköping, Sweden.
    Kernel Methods for Accurate UWB-Based Ranging with Reduced Complexity2016In: IEEE Transactions on Wireless Communications, ISSN 1536-1276, E-ISSN 1558-2248, Vol. 15, no 3, p. 1783-1793Article in journal (Refereed)
    Abstract [en]

    Accurate and robust positioning in multipath environments can enable many applications, such as search-and-rescue and asset tracking. For this problem, ultra-wideband (UWB) technology can provide the most accurate range estimates, which are required for range-based positioning. However, UWB still faces a problem with non-line-of-sight (NLOS) measurements, in which the range estimates based on time-of-arrival (TOA) will typically be positively biased. There are many techniques that address this problem, mainly based on NLOS identification and NLOS error mitigation algorithms. However, these techniques do not exploit all available information in the UWB channel impulse response. Kernel-based machine learning methods, such as Gaussian Process Regression (GPR), are able to make use of all information, but they may be too complex in their original form. In this paper, we propose novel ranging methods based on kernel principal component analysis (kPCA), in which the selected channel parameters are projected onto a nonlinear orthogonal high-dimensional space, and a subset of these projections is then used as an input for ranging. We evaluate the proposed methods using real UWB measurements obtained in a basement tunnel, and found that one of the proposed methods is able to outperform state-of-the-art, even if little training samples are available.

  • 4839.
    Savitchi, Luminita
    et al.
    Linköping University, Department of Science and Technology. Linköping University, The Institute of Technology.
    Vahlberg, Cecilia
    Linköping University, Department of Physics, Chemistry and Biology, Molecular Surface Physics and Nano Science. Linköping University, Faculty of Science & Engineering.
    Petoral, Rodrigo Jr
    Linköping University, Department of Physics, Chemistry and Biology, Molecular Surface Physics and Nano Science. Linköping University, Faculty of Science & Engineering.
    Uvdal, Kajsa
    Linköping University, Department of Physics, Chemistry and Biology, Molecular Surface Physics and Nano Science. Linköping University, Faculty of Science & Engineering.
    Mixed monolayers to promote G-protein adsorption: α2A- Adrenergic receptor-derived peptides coadsorbed with formyl-terminated oligopeptides2007In: Langmuir, ISSN 0743-7463, E-ISSN 1520-5827, Vol. 23, no 16, p. 8474-8479Article in journal (Refereed)
    Abstract [en]

    Pure and mixed monolayers of a synthetic peptide, GPR-i3n, derived from the third intracellular loop of the α2 adrenergic receptor and a shorter inactive oligopeptide, N-formyl-(Gly)3-(Cys) (called 3GC), were prepared on gold surfaces. The mixing ratio of the GPR-i3n and 3GC was used to control G-protein binding capability. The GPR-i3n peptide is specially designed for bovine G-protein selectivity and has been proven to have high affinity to G-proteins [Vahlberg, C.; Petoral, R. M., Jr.; Lindell, C.; Broo, K.; Uvdal, K. Langmuir 2006, 22 (17), 7260−7264]. Pure 3GC monolayers show very low protein adsorption capability. In this study, 3GC is chosen as a coadsorbent, with the aim to induce molecular conformational changes during monolayer formation to enhance G-protein adsorption. A full characterization of the mixed monolayers was done. The monolayer thickness and the mass-related surface coverage for both GPR-i3n and 3GC were investigated using radio labeling. The GPR-i3n was labeled by 125I-targeting tyrosine, and the activity was measured by using radioimmunoassay (RIA). The formation and chemical composition of GPR-i3n and 3GC monolayers were investigated using X-ray photoelectron spectroscopy, and it is shown that both GPR-i3n and 3GC bind chemically to the gold surface. The interaction between the mixed monolayers and G-proteins was investigated by means of real-time surface plasmon resonance. There is a higher protein binding capacity to the monolayer when the GPR-i3n peptide is intermixed with the 3GC coadsorbent, despite the fact that the 3GC itself has a very low G-protein binding capability. This supports a molecular reorientation at the surface, while 3GC is intermixed with GPR-i3n.

  • 4840.
    Savitski, Dzmitry
    et al.
    TU Ilmenau, Germany.
    Ivanov, Valentin
    TU Ilmenau, Germany.
    Schleinin, Dmitrij
    TU Ilmenau, Germany.
    Puetz, Thomas
    Lucas Varity GmbH, Germany.
    Lee, Chih Feng
    Linköping University, Department of Electrical Engineering, Vehicular Systems. Linköping University, Faculty of Science & Engineering.
    Advanced Control Functions Of Decoupled Electro-Hydraulic Brake System2016In: 2016 IEEE 14TH INTERNATIONAL WORKSHOP ON ADVANCED MOTION CONTROL (AMC), IEEE , 2016, p. 310-317Conference paper (Refereed)
    Abstract [en]

    The paper presents results of analytical and experimental investigations on advanced control functions of decoupled electro-hydraulic brake system. These functions address continuous wheel slip control, variation of the brake pedal feel, and brake judder compensation. The performed study demonstrates that the electro-hydraulic brake system has improved performance by relevant criteria of safety and driving comfort both for conventional and electric vehicles.

  • 4841.
    Savoyant, A.
    et al.
    Aix Marseille University, France.
    Alnoor, Hatim
    Linköping University, Department of Science and Technology. Linköping University, Faculty of Science & Engineering.
    Bertaina, S.
    Aix Marseille University, France.
    Nur, Omer
    Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, Faculty of Science & Engineering.
    Willander, Magnus
    Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, Faculty of Science & Engineering.
    EPR investigation of pure and Co-doped ZnO oriented nanocrystals2017In: NANOTECHNOLOGY, ISSN 0957-4484, Vol. 28, no 3, article id 035705Article in journal (Refereed)
    Abstract [en]

    Pure and cobalt-doped zinc oxide aligned nanorods have been grown by the low-temperature (90 degrees C) aqueous chemical method on amorphous ZnO seed layer, deposited on a sapphire substrate. High crystallinity of these objects is demonstrated by the electron paramagnetic resonance investigation at liquid helium temperature. The successful incorporation of Co2+ ions in substitution of Zn2+ ones in the ZnO matrix has also been confirmed. A drastic reduction of intrinsic ZnO nanorods core defects is observed in the Co-doped samples, which enhances the structural quality of the NRs. The quantification of substitutional Co2+ ions in the ZnO matrix is achieved by comparison with a reference sample. The findings in this study indicate the potential of using the low-temperature aqueous chemical approach for synthesizing material for spintronics applications.

  • 4842.
    Savoyant, A.
    et al.
    Aix Marseille University, France.
    Alnoor, Hatim
    Linköping University, Department of Science and Technology. Linköping University, Faculty of Science & Engineering.
    Pilone, O.
    Aix Marseille University, France.
    Nur, Omer
    Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, Faculty of Science & Engineering.
    Willander, Magnus
    Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, Faculty of Science & Engineering.
    Core-defect reduction in ZnO nanorods by cobalt incorporation2017In: Nanotechnology, ISSN 0957-4484, E-ISSN 1361-6528, Vol. 28, no 28, article id 285705Article in journal (Refereed)
    Abstract [en]

    Zinc oxide (ZnO) nanorods grown by the low-temperature (90 degrees C) aqueous chemical method with different cobalt concentration within the synthesis solution (from 0% to 15%), are studied by electron paramagnetic resonance (EPR), just above the liquid helium temperature. The anisotropic spectra of substitutional Co2+ reveal a high crystalline quality and orientation of the NRs, as well as the probable presence of a secondary disordered phase of ZnO: Co. The analysis of the EPR spectra indicates that the disappearance of the paramagnetic native core-defect (CD) at g similar to 1.96 is correlated with the apparition of the Co2+ ions lines, suggesting a gradual neutralization of the former by the latter. We show that only a little amount of cobalt in the synthesis solution (about 0.2%) is necessary to suppress almost all these paramagnetic CDs. This gives insight in the experimentally observed improvement of the crystal quality of diluted ZnO: Co nanorods, as well as into the control of paramagnetic defects in ZnO nanostructures.

  • 4843.
    Savvidis, Charalampos
    et al.
    Linköping University, Faculty of Science & Engineering. Linköping University, Department of Electrical Engineering, Vehicular Systems.
    Geng, Zeyang
    Linköping University, Department of Electrical Engineering. Linköping University, Faculty of Science & Engineering.
    Onboard Impedance Diagnostics Method of Li-ion Traction Batteries using Pseudo-Random Binary Sequence2015Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Environmental and economic reasons have lead automotive companies towards the direction of EVs and HEVs. Stricter emission legislations along with the consumer needs for more cost-efficient and environmental friendly vehicles have increased immensely the amount of hybrid and electric vehicles available in the market. It is essential though for Li-ion batteries, the main propulsion force of EVs and HEVs, to be able to read the battery characteristics in a high accuracy manner, predict life expectancy and behaviour and act accordingly. The following thesis constitutes a concept study of a battery diagnostics method. The method is based on the notion of a pseudo-random binary signal used as the current input and from its voltage response, the impedance is used for the estimation of parameters such as the state of charge and more. The feasibility of the PRBS method at a battery cell has been examined through various tests, both in an experimental manner at the lab but also in a simulation manner. The method is compared for validation against the electrochemical impedance spectroscopy method which is being used as a reference. For both the experimental and the simulation examinations, the PRBS method has been validated and proven to work. No matter the change in the parameters of the system, the method behaves in a similar manner as in the reference EIS method.

    The level of detail in the research and the performed experiments is what makes the significance of the results of high importance. The method in all ways has been proven to work in the concept study and based on the findings, if implemented on an EV’s or HEV’s electric drive line and the same functionality is observed, be used as a diagnostics method of the battery of the vehicle.

  • 4844.
    Sazonov, R. V.
    et al.
    Tomsk Polytech University, Russia.
    Kholodnaya, G. E.
    Tomsk Polytech University, Russia.
    Ponomarev, D. V.
    Tomsk Polytech University, Russia.
    Zhirkov, Igor
    Linköping University, Department of Physics, Chemistry and Biology, Thin Film Physics. Linköping University, Faculty of Science & Engineering.
    Pulsed plasma chemical synthesis of carbon-containing titanium oxide-based composite2017In: Fullerenes, nanotubes, and carbon nanostructures (Print), ISSN 1536-383X, E-ISSN 1536-4046, Vol. 25, no 9, p. 526-530Article in journal (Refereed)
    Abstract [en]

    The carbon-containing titanium oxide-based composite was first obtained using a pulsed plasma chemical method. The composite was obtained from the following reagents: TiCl4, CH4, and O-2. The physical and chemical properties of the TixCyOz composite powders were studied (morphology, chemical, elemental and phase composition). The presence of spherical particles and the cubic and prismatic particles were typical for the synthesised carbon-containing titanium oxide-based composites. The large particles are observed (the average size exceeds 150nm) and smaller particles (the average size is 15-30nm). The presence of the dense layer of amorphous carbon (10-15nm thick) around particles is typical for the composites. The peak with a maximum of 1080cm(-1) is registered in IR absorption spectrum of the TixCyOz synthesised composite. The presence of IR radiation in this region of the spectrum is typical for the deformation of atomic oscillations in the Ti-O-C bond, which indicates that carbon and titanium in the composite are bound through oxygen. The content of the defined amount of titanium carbide has not been detected.

  • 4845.
    Schall, Anna P.
    et al.
    Haverford Coll, PA 19041 USA.
    Iavicoli, Patrizia
    CSIC, Spain.
    John Qi, Zhengling
    University of Penn, PA 19104 USA.
    Menko, Julien
    Haverford Coll, PA 19041 USA.
    Lu, Ye
    University of Penn, PA 19104 USA.
    Linares, Mathieu
    Linköping University, Department of Physics, Chemistry and Biology, Theoretical Chemistry. Linköping University, Faculty of Science & Engineering.
    de Paula, Julio C.
    Lewis and Clark Coll, OR 97219 USA.
    Amabilino, David B.
    CSIC, Spain.
    Johnson, A. T.
    University of Penn, PA 19104 USA.
    Smith, Walter F.
    Haverford Coll, PA 19041 USA.
    Photoconductivity of Nanofilaments That are Self-Assembled from a Porphyrin with Long Alkyl-Chain Substituents2015In: The Journal of Physical Chemistry C, ISSN 1932-7447, E-ISSN 1932-7455, Vol. 119, no 46, p. 26154-26163Article in journal (Refereed)
    Abstract [en]

    Photoelectronically active nanostructures that are Self-assembled from organic rnolecules hold the prortu se of tailored functionality.with simple and inexpensive production. Comparison of nanoWires assembled from related componnds can give important insightS into the details of self-assembly and the,conduction meehanisms. We report the photoconductivity of nanofibers that are self-assembled from a porphyrin With long alkyl substituents. In contrast to previously studied porphyrin nanowires, the photoconductivity increases as atthospheric O-2 is increased. This can be explained-using the same model aS used in the previous studies, by assuming a different, line-up of the bands of the nanofilaments. with the electrode Fermi level. However, this model does not explain our observation that-at O-2 concentrations above 1%, the conduction increases with continued- illunation; this may be due to photoactivation of shallow O-2 adsorption sites. The overall conduction level is low even at high O-2 Concentration, because the alkyl substituents form an insulating sheath around the rianofibers. Such inSulation could be valuable in applications where it would prevent cross-talk between signal S darried in different nanofilaments. Schottky barriers at the interface between- organic nanostructures and electrodes strongly affect conduction and photoconduction, and are strongly influenced by atmospheric gases such, as O-2.

  • 4846.
    Schamai, Wladimir
    et al.
    Airbus Group Innovations, Germany.
    Buffoni, Lena
    Linköping University, Department of Computer and Information Science, Software and Systems. Linköping University, Faculty of Science & Engineering.
    Albarello, Nicolas
    Airbus Group Innovations, France.
    Fontes De Miranda, Pablo
    Airbus Group Innovations, France.
    Fritzson, Peter
    Linköping University, Department of Computer and Information Science, Software and Systems. Linköping University, Faculty of Science & Engineering.
    An Aeronautic Case Study for Requirement Formalization and Automated Model Composition in Modelica2015In: Proceedings of the 11th International Modelica Conference, Versailles, France, September 21-23, 2015 / [ed] Peter Fritzson, Hilding Elmqvist, Linköping: Linköping University Electronic Press, 2015, p. 911-920, article id 99Conference paper (Refereed)
    Abstract [en]

    Building complex systems from models that have been developed separately without modifying existing code is a challenging task faced on a regular basis in multiple contexts including design verification. To address this issue an approach has been developed for automating dynamic system model composition by defining the minimum set of information that is necessary to the composition process. In this paper a design and implementation of this approach for standard Modelica is presented in the context of an application case study – the verification of a new design for spoiler activation against requirements.

  • 4847.
    Scharis, Inger
    et al.
    Linköping University, Department of Physics, Chemistry and Biology, Biology. Linköping University, Faculty of Science & Engineering.
    Amundin, Mats
    Linköping University, Department of Physics, Chemistry and Biology, Biology. Linköping University, Faculty of Science & Engineering. Kolmarden Wildlife Park, Sweden.
    Cross-fostering in gray wolves (Canis lupus lupus)2015In: Zoo Biology, ISSN 0733-3188, E-ISSN 1098-2361, Vol. 34, no 3, p. 217-222Article in journal (Refereed)
    Abstract [en]

    Cross-fostering in canids, with captive-bred pups introduced into endangered wild populations, might aid conservation efforts by increasing genetic diversity and lowering the risk of inbreeding depression. The gray wolf (Canis lupus lupus) population in Scandinavia suffers from severe inbreeding due to a narrow genetic base and geographical isolation. This study aimed at evaluating the method to cross-foster wolf pups from zoo-born to zoo-born litters. The following was assessed: female initial acceptance of foster pups, growth rate in relation to age difference between foster pups and pups in recipient litters and survival over the first 33 weeks. The study included four litters added by two foster pups in each. The age differences between the foster pups and the recipient litters were 2-8 days. After augmentation, all four females accepted the foster pups, demonstrated by her moving the entire litter to a new den site. Growth rate was dependent on the age difference of the pups in the foster litters, with a considerably slower growth rate in the 8 days younger pups. However, these pups later appeared to be at no disadvantage. Foster pups had a higher survival rate than females pups, however, the causes of death were probably not kin or non-kin related. The results indicate that cross-fostering works in gray wolves and that this might be a plausible way to increase genetic variation in the wild population.

  • 4848.
    Scharis, Inger
    et al.
    Linköping University, Faculty of Science & Engineering. Linköping University, Department of Physics, Chemistry and Biology.
    Rasmussen, Gregory S. A.
    Painted Dog Conservation, Hwange National Park, PO Box 72, Dete, Zimbabwe.
    Laska, Matthias
    Linköping University, Department of Physics, Chemistry and Biology, Biology. Linköping University, Faculty of Science & Engineering.
    Using morphometrics to quantitatively differentiateAfrican wild dog footprints from domestic dogfootprints – a pilot study2016In: African Journal of Ecology, ISSN 0141-6707, E-ISSN 1365-2028, Vol. 54, no 1Article in journal (Refereed)
    Abstract [en]

    Reliable population estimation and species inventories areimportant for wildlife conservation, but such estimationsare often difficult due to unreliable identification of thespecies in question. Furthermore, for predator conflictresolution, it is essential to be able to reliably identify thepredator. This study presents a new method to quantitativelydistinguish African wild dog (Lycaon pictus) footprintsfrom feral domestic dog (Canis lupus familiaris)footprints. Footprint photographs were digitally processedusing Photoshop and the NIH image processing softwareImageJ, and total pad area and angles between thecentroids of the backpad and the digits of the paw weremeasured. Pad angles showed statistically significantdifferences between the two species and, with the exceptionthat there was no significant difference in pad areabetween African wild dog females and domestic dog males,total pad areas were also diagnostic. Consequently, thecombination of total pad area and the angle betweenbackpad and digits are useful discriminators to reliablyidentify the species from an unknown footprint.

  • 4849.
    Schedin, Staffan
    et al.
    Umeå universitet.
    Hassan, Osama
    Linköping University, Department of Science and Technology, Communications and Transport Systems. Linköping University, Faculty of Science & Engineering.
    WORK INTEGRATED LEARNING MODEL IN RELATION TO CDIO STANDARDS2016In: Journal of Applied Research in Higher Education, ISSN 2050-7003, E-ISSN 1758-1184, ISSN 2050-7003, Vol. 8, no 3, p. 278-286Article in journal (Refereed)
    Abstract [en]

    In this paper, it is attempted to develop a model of work integrated learning for undergraduate engineering students in relation to the international CDIO-initiative1 standard 7 (Integrated Learning Experiences) and 8 (Active Learning). The model is based on an organized collaboration with a number of industrial partners in the surrounding geographic region. As a part of the collaboration, each participating student is guaranteed an internship at a chosen company during two summer periods. In the model, company based projects are integrated with some of the study program courses.Moreover, the participating students are given a possibility to perform their final thesis at the chosen company. The evaluation of the model shows that that the company based projects promote interdisciplinary learning as well as fostering system building skills and personal communication skills. Moreover, the developed learning model supports the expected learning outcomes, especially with regards to interpersonal skills, teamwork and communication. Moreover, it is discussed the roleof cultural- social perspective and peer-learning in enhancing the developed learning model from apedagogical point of view.

  • 4850.
    Schlauer, Christian
    et al.
    Linköping University, Department of Management and Engineering, Engineering Materials. Linköping University, Faculty of Science & Engineering.
    Simonsson, Kjell
    Linköping University, Department of Management and Engineering, Solid Mechanics. Linköping University, Faculty of Science & Engineering.
    Moverare, Johan
    Linköping University, Department of Management and Engineering, Engineering Materials. Linköping University, Faculty of Science & Engineering.
    The effect of machining on residual stresses and low cycle fatigue life of Inconel 718 gas turbine discs2002Report (Other academic)
949596979899100 4801 - 4850 of 6066
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