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  • 301.
    Asad, Sara
    et al.
    Linköping University, Department of Computer and Information Science. Linköping University, Faculty of Science & Engineering.
    Calmfors, Tomas
    Linköping University, Department of Computer and Information Science. Linköping University, Faculty of Science & Engineering.
    Forzelius, Magnus
    Linköping University, Department of Computer and Information Science. Linköping University, Faculty of Science & Engineering.
    Fransson, Ellen
    Linköping University, Department of Computer and Information Science. Linköping University, Faculty of Science & Engineering.
    Granath, Vilhelm
    Linköping University, Department of Computer and Information Science. Linköping University, Faculty of Science & Engineering.
    Johansson, Axel
    Linköping University, Department of Computer and Information Science. Linköping University, Faculty of Science & Engineering.
    Karlsson, Lisa
    Linköping University, Department of Computer and Information Science. Linköping University, Faculty of Science & Engineering.
    Werdin, Andreas
    Linköping University, Department of Computer and Information Science. Linköping University, Faculty of Science & Engineering.
    Pralinbutiken: Erfarenheter från utvecklingen av en webbapplikation2015Independent thesis Basic level (degree of Bachelor), 12 credits / 18 HE creditsStudent thesis
    Abstract [en]

    This report describes the process of developing an e-shop for self-composed boxes

    of chocolate pralines, Pralinbutiken, based on agile development methodology. The work has been carried out by a team of eight students at Linköping University.

    The team came up with the idea and concept to Pralinbutiken. The report addresses the experiences of the development process, working methods and regarding the team. Further are technical issues and solutions raised during the project presented and discussed.

    The goal of Pralinbutiken is to offer a self-composed box of pralines tailored after the customers' own allergies and preferences.

    Thanks to Ejes Chocolate, Pralinaskar.se and Dark Passion for your contribution with pictures of products to the e-shop. 

  • 302.
    Asada, Satoshi
    et al.
    Department of Electronic Science and Engineering, Kyoto University, Katsura, Nishikyo, Kyoto, Japan.
    Kimoto, Tsunenobu
    Department of Electronic Science and Engineering, Kyoto University, Katsura, Nishikyo, Kyoto, Japan.
    Ivanov, Ivan Gueorguiev
    Linköping University, Department of Physics, Chemistry and Biology, Semiconductor Materials. Linköping University, Faculty of Science & Engineering.
    Calibration on wide-ranging aluminum doping concentrations by photoluminescence in high-quality uncompensated p-type 4H-SiC2017In: Applied Physics Letters, ISSN 0003-6951, E-ISSN 1077-3118, Vol. 111, no 7, article id 072101Article in journal (Refereed)
    Abstract [en]

    Previous work has shown that the concentration of shallow dopants in a semiconductor can be estimated from the photoluminescence (PL) spectrum by comparing the intensity of the bound-to-the- dopant exciton emission to that of the free exciton. In this work, we study the low-temperature PL of high-quality uncompensated Al-doped p-type 4H-SiC and propose algorithms for determining the Al-doping concentration using the ratio of the Al-bound to free-exciton emission. We use three different cryogenic temperatures (2, 41, and 79 K) in order to cover the Al-doping range from mid 10(14) cm(-3) up to 10(18) cm(-3). The Al-bound exciton no-phonon lines and the strongest free-exciton replica are used as a measure of the bound-and free-exciton emissions at a given temperature, and clear linear relationships are obtained between their ratio and the Al-concentration at 2, 41, and 79 K. Since nitrogen is a common unintentional donor dopant in SiC, we also discuss the criteria allowing one to determine from the PL spectra whether a sample can be considered as uncompensated or not. Thus, the low-temperature PL provides a convenient non-destructive tool for the evaluation of the Al concentration in 4H-SiC, which probes the concentration locally and, therefore, can also be used for mapping the doping homogeneity. Published by AIP Publishing.

  • 303.
    Aschebrock, Thilo
    et al.
    University of Bayreuth, Germany.
    Armiento, Rickard
    Linköping University, Department of Physics, Chemistry and Biology, Theoretical Physics. Linköping University, Faculty of Science & Engineering.
    Kuemmel, Stephan
    University of Bayreuth, Germany.
    Challenges for semilocal density functionals with asymptotically nonvanishing potentials2017In: Physical Review B, ISSN 2469-9950, E-ISSN 2469-9969, Vol. 96, no 7, article id 075140Article in journal (Refereed)
    Abstract [en]

    The Becke-Johnson model potential [A. D. Becke and E. R. Johnson, J. Chem. Phys. 124, 221101 ( 2006)] and the potential of the AK13 functional [R. Armiento and S. Kummel, Phys. Rev. Lett. 111, 036402 ( 2013)] have been shown to mimic features of the exact Kohn-Sham exchange potential, such as step structures that are associated with shell closings and particle-number changes. A key element in the construction of these functionals is that the potential has a limiting value far outside a finite system that is a system-dependent constant rather than zero. We discuss a set of anomalous features in these functionals that are closely connected to the nonvanishing asymptotic potential. The findings constitute a formidable challenge for the future development of semilocal functionals based on the concept of a nonvanishing asymptotic constant.

  • 304.
    Aschebrock, Thilo
    et al.
    University of Bayreuth, Germany.
    Armiento, Rickard
    Linköping University, Department of Physics, Chemistry and Biology, Theoretical Physics. Linköping University, Faculty of Science & Engineering.
    Kuemmel, Stephan
    University of Bayreuth, Germany.
    Orbital nodal surfaces: Topological challenges for density functionals2017In: Physical Review B, ISSN 2469-9950, E-ISSN 2469-9969, Vol. 95, no 24, article id 245118Article in journal (Refereed)
    Abstract [en]

    Nodal surfaces of orbitals, in particular of the highest occupied one, play a special role in Kohn-Sham density-functional theory. The exact Kohn-Sham exchange potential, for example, shows a protruding ridge along such nodal surfaces, leading to the counterintuitive feature of a potential that goes to different asymptotic limits in different directions. We show here that nodal surfaces can heavily affect the potential of semilocal density-functional approximations. For the functional derivatives of the Armiento-Kummel (AK13) [Phys. Rev. Lett. 111, 036402 (2013)] and Becke88 [Phys. Rev. A 38, 3098 (1988)] energy functionals, i.e., the corresponding semilocal exchange potentials, as well as the Becke-Johnson [J. Chem. Phys. 124, 221101 (2006)] and van Leeuwen-Baerends (LB94) [Phys. Rev. A 49, 2421 (1994)] model potentials, we explicitly demonstrate exponential divergences in the vicinity of nodal surfaces. We further point out that many other semilocal potentials have similar features. Such divergences pose a challenge for the convergence of numerical solutions of the Kohn-Sham equations. We prove that for exchange functionals of the generalized gradient approximation (GGA) form, enforcing correct asymptotic behavior of the potential or energy density necessarily leads to irregular behavior on or near orbital nodal surfaces. We formulate constraints on the GGA exchange enhancement factor for avoiding such divergences.

  • 305.
    Asekritova, Irina
    et al.
    Linköping University, Department of Mathematics, Mathematics and Applied Mathematics. Linköping University, Faculty of Science & Engineering.
    Karlovich, Yuri
    University of Autonoma Estado Morelos, Mexico.
    Kruglyak, Natan
    Linköping University, Department of Mathematics, Mathematics and Applied Mathematics. Linköping University, Faculty of Science & Engineering.
    One-sided invertibility of discrete operators and their applications2018In: Aequationes Mathematicae, ISSN 0001-9054, E-ISSN 1420-8903, Vol. 92, no 1, p. 39-73Article in journal (Refereed)
    Abstract [en]

    For p is an element of [1, infinity], we establish criteria for the one-sided invertibility of binomial discrete difference operators A = aI - bV on the space l(p) = l(p)(Z), where a, b is an element of l(infinity), I is the identity operator and the isometric shift operator V is given on functions f. lp by (Vf)(n) = f (n+ 1) for all n is an element of Z. Applying these criteria, we obtain criteria for the one-sided invertibility of binomial functional operators A = aI - bU(alpha) on the Lebesgue space L-p(R+) for every p is an element of [1, infinity], where a, b is an element of L-infinity (R+), a is an orientation-preserving bi-Lipschitz homeomorphism of [0, +infinity] onto itself with only two fixed points 0 and infinity, and U-alpha is the isometric weighted shift operator on L-p(R+) given by U(alpha)f = (alpha)(1/p)(f circle alpha). Applications of binomial discrete operators to interpolation theory are given.

  • 306.
    Asekritova, Irina
    et al.
    Linköping University, Department of Mathematics, Mathematics and Applied Mathematics. Linköping University, Faculty of Science & Engineering.
    Kruglyak, Natan
    Linköping University, Department of Mathematics, Mathematics and Applied Mathematics. Linköping University, Faculty of Science & Engineering.
    Mastylo, Mieczyslaw
    University of Poznan, Poland.
    Interpolation of Fredholm Operators2016In: Advances in Mathematics, ISSN 0001-8708, E-ISSN 1090-2082, Vol. 295, p. 421-496Article in journal (Refereed)
  • 307.
    Asghar, Adeel
    et al.
    Linköping University, Department of Computer and Information Science, Software and Systems. Linköping University, Faculty of Science & Engineering.
    Pfeiffer, Andreas
    DLR Institute of System Dynamic and Control, Wessling, Tyskland.
    Palanisamy, Arunkumar
    Linköping University, Department of Computer and Information Science, Software and Systems. Linköping University, Faculty of Science & Engineering.
    Mengist, Alachew
    Linköping University, Department of Computer and Information Science, Software and Systems. Linköping University, Faculty of Science & Engineering.
    Sjölund, Martin
    Linköping University, Department of Computer and Information Science, Software and Systems. Linköping University, Faculty of Science & Engineering.
    Pop, Adrian
    Linköping University, Department of Computer and Information Science, Software and Systems. Linköping University, Faculty of Science & Engineering.
    Fritzson, Peter
    Linköping University, Department of Computer and Information Science, Software and Systems. Linköping University, Faculty of Science & Engineering.
    Automatic Regression Testing of Simulation Models and Concept for Simulation of Connected FMUs in PySimulator2015In: Proceedings of the 11th International Modelica Conference: Versailles, France, September 21-23, 2015 / [ed] Peter Fritzson, Hilding Elmqvist, Linköping, 2015, p. 671-679Conference paper (Refereed)
    Abstract [en]

    The Modelica and FMI tool ecosystem is growing each year with new tools and methods becoming available. The open Modelica standard promises portability but it is important to ensure that a certain model behaves the same in different Modelica tools or in a different version of the same tool. It is also very important (for model evolution) to check that a new version of the same model produces comparable results. Finally, it is desirable to verify that a model exported in FMU form from a Modelica tool gives exactly the same results as the original model. This paper presents a framework for automatic regression testing as part of PySimulator which provides an efficient and concise way of testing if a model or a range of models behaves in the same way in several tools or versions of a tool by checking that the results produced are essentially identical. The FMI standard has been adopted by many tool vendors and is growing in popularity each year. This paper proposes a concept for building and simulating a system made from connected FMUs generated by different tools. The FMUs for Co-Simulation can be connected together using a GUI. The system model built graphically in this way can be saved for later use or simulated directly inside PySimulator. Active development is going on to support simulation of connected FMUs for Model Exchange.

  • 308.
    Asgharian Bourkheili, Ehsan
    Linköping University, Department of Management and Engineering, Industrial Economics. Linköping University, Faculty of Science & Engineering.
    Performance in Franchise Systems: The Franchisee Perspective2015Doctoral thesis, monograph (Other academic)
    Abstract [en]

    During the last decades, franchising as an organizational form has received a lot of attention from researchers and practitioners alike. While many studies have examined various aspects of franchising from the franchisor's perspective, little research has taken the franchisee’s perspective. Therefore, given the importance of franchisees in a franchise system, the lack of research about consequences from the franchisee's perspective, and that many of the previous studies have taken a top-bottom view, this research concentrated on the franchisee's performance. This study focused on business format franchising in the restaurant industry in two countries, Iran and Sweden.

    In this study, the three perspectives of entrepreneurship, strategic management, and marketing were used to study the franchisee’s performance. Moreover, the resourcebased view, relational view, and relational exchange theory have been used to find the influential factors in a franchisee’s performance. Therefore, by considering franchising as a mutual relationship and examining the influential factors in a franchisee's performance, the related factors of both the franchisor and franchisee, as well as the relationship between them, were examined.

    According to the franchisee’s related factors, the franchisor's related factors, and the relationship and environmental factors, 12 main hypotheses and 9 sub-hypotheses were developed. In total, 191 usable questionnaires from Sweden and Iran, comprising a response rate of 22 percent, were returned from the franchisees. In this study, confirmatory factor analysis was used to test the construct measurement; to test the hypothesis, hierarchical multiple regression analysis was performed. Moreover, the Chow test was conducted to integrate the data from these two countries.

    A primary contribution of this study is taking a bottom-top view in franchising research. This study also provided a detailed and holistic view about the consequences of franchising for franchisees. Moreover, this study, offers important contributions toward understanding entrepreneurial activities, as a controversial issue, in franchising outlets.

    The results provide interesting insights into the franchisee’s performance. While the franchisees’ related factors of absorptive capacity, Kirznerian entrepreneurial orientation, and social capital positively affected their performance, Schumpeterian entrepreneurial orientation and human capital did not affect their performance. Moreover, the franchisor’s related factors of system profitability, brand reputation, advertisement and providing raw material had a positive influence on the performance. However, training did not cause a difference in the franchisee’s performance. All relationship factors also positively affected the performance, and conflict and satisfaction mediated the relationship between trust and performance. Finally, the implications of this study and suggestions for further contributions in this stream of research are discussed.

  • 309.
    Ashaduzzaman, Md
    et al.
    Linköping University, Department of Physics, Chemistry and Biology, Biosensors and Bioelectronics. Linköping University, Faculty of Science & Engineering. University of Dhaka, Bangladesh.
    Anto Antony, Aswathi
    Linköping University, Department of Physics, Chemistry and Biology, Biosensors and Bioelectronics. Linköping University, Faculty of Science & Engineering.
    Murugan, N. Arul
    Royal Institute Technology, Sweden.
    Deshpande, Swapneel R.
    Linköping University, Department of Physics, Chemistry and Biology, Biosensors and Bioelectronics. Linköping University, Faculty of Science & Engineering.
    Turner, Anthony
    Linköping University, Department of Physics, Chemistry and Biology, Biosensors and Bioelectronics. Linköping University, Faculty of Science & Engineering.
    Tiwari, Ashutosh
    Linköping University, Department of Physics, Chemistry and Biology, Biosensors and Bioelectronics. Linköping University, Faculty of Science & Engineering. Tekidag AB, UCS, S-58330 Linkoping, Sweden.
    Studies on an on/off-switchable immunosensor for troponin T2015In: Biosensors & bioelectronics, ISSN 0956-5663, E-ISSN 1873-4235, Vol. 73, p. 100-107Article in journal (Refereed)
    Abstract [en]

    Regeneration is a key goal in the design of immunosensors. In this study, we report the temperature-regulated interaction of N-isopropylacrylamide (PNIPAAm) functionalised cardiac troponin T (cTnT) with anti-cTnT. Covalently bonded PNIPAAm on an anti-cTnT bioelectrode showed on/off-switchability, regeneration capacity and temperature triggered sensitivity for cTnT. Above the lower critical solution temperature (LCST), PNIPAAm provides a liphophilic microenvironment with specific volume reduction at the bioelectrode surface, making available binding space for cTnT, and facilitating analyte recognition. Computational studies provide details about the structural changes occurring at the electrode above and below the LCST. Furthermore, free energies associated with the binding of cTnT with PNIPAAm at 25 (Delta G(coil)=-6.0 Kcal/mole) and 37 degrees C (Delta G(globular)=-41.0 kcal/mole) were calculated to elucidate the interaction and stability of the antigen-antibody complex. The responsiveness of such assemblies opens the way for miniaturised, smart immuno-technologies with built-in programmable interactions of antigen-antibody upon receiving stimuli.

  • 310.
    Ashaduzzaman, Md.
    et al.
    Linköping University, Department of Physics, Chemistry and Biology, Biosensors and Bioelectronics. Linköping University, Faculty of Science & Engineering. UCS, Institute Adv Mat, Teknikringen 4A,Mjardevi Science Pk, SE-58330 Linkoping, Sweden.
    Deshpande, Swapneel R.
    Linköping University, Department of Physics, Chemistry and Biology, Biosensors and Bioelectronics. Linköping University, Faculty of Science & Engineering. UCS, Institute Adv Mat, Teknikringen 4A,Mjardevi Science Pk, SE-58330 Linkoping, Sweden.
    Arul Murugan, N.
    Royal Institute Technology, Sweden.
    Kumar Mishra, Yogendra
    University of Kiel, Germany.
    Turner, Anthony
    Linköping University, Department of Physics, Chemistry and Biology, Biosensors and Bioelectronics. Linköping University, Faculty of Science & Engineering.
    Tiwari, Ashutosh
    Linköping University, Department of Physics, Chemistry and Biology. Linköping University, Faculty of Science & Engineering. UCS, Institute Adv Mat, Teknikringen 4A,Mjardevi Science Pk, SE-58330 Linkoping, Sweden; Vinoba Bhave Research Institute, India.
    On/off-switchable LSPR nano-immunoassay for troponin-T2017In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 7, article id 44027Article in journal (Refereed)
    Abstract [en]

    Regeneration of immunosensors is a longstanding challenge. We have developed a re-usable troponin-T (TnT) immunoassay based on localised surface plasmon resonance (LSPR) at gold nanorods (GNR). Thermosensitive poly(N-isopropylacrylamide) (PNIPAAM) was functionalised with anti-TnT to control the affinity interaction with TnT. The LSPR was extremely sensitive to the dielectric constant of the surrounding medium as modulated by antigen binding after 20 min incubation at 37 degrees C. Computational modelling incorporating molecular docking, molecular dynamics and free energy calculations was used to elucidate the interactions between the various subsystems namely, IgG-antibody (c. f., anti-TnT), PNIPAAM and/or TnT. This study demonstrates a remarkable temperature dependent immuno-interaction due to changes in the PNIPAAM secondary structures, i.e., globular and coil, at above or below the lower critical solution temperature (LCST). A series of concentrations of TnT were measured by correlating the lambda(LSPR) shift with relative changes in extinction intensity at the distinct plasmonic maximum (i. e., 832 nm). The magnitude of the red shift in lambda(LSPR) was nearly linear with increasing concentration of TnT, over the range 7.6 x 10(-15) to 9.1 x 10(-4) g/mL. The LSPR based nano-immunoassay could be simply regenerated by switching the polymer conformation and creating a gradient of microenvironments between the two states with a modest change in temperature.

  • 311. Ashaduzzaman, Md
    et al.
    Parlak, Onur
    Linköping University, Department of Physics, Chemistry and Biology, Biosensors and Bioelectronics. Linköping University, Faculty of Science & Engineering.
    Turner, Anthony
    Linköping University, Department of Physics, Chemistry and Biology, Biosensors and Bioelectronics. Linköping University, Faculty of Science & Engineering.
    Tiwari, Ashutosh
    Linköping University, Department of Physics, Chemistry and Biology, Biosensors and Bioelectronics. Linköping University, Faculty of Science & Engineering.
    Fabrication of on/off-switchable enzymatic bioreactor for smart bioelectronics.2015In: Sweden-Japan Seminar on Nanomaterials and Nanotechnology – SJS-Nano, Linköping, Sweden, 10-11 March 2015., Japan Society for the Promotion of Science (JSPS), Stockholm , 2015, p. 36-37Conference paper (Refereed)
  • 312.
    Asif, Muhammad H.
    et al.
    COMSATS Institute Informat Technology, Pakistan; Acromed Invest AB, Sweden.
    Danielsson, Bengt
    Acromed Invest AB, Sweden.
    Willander, Magnus
    Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, Faculty of Science & Engineering.
    ZnO Nanostructure-Based Intracellular Sensor2015In: Sensors, ISSN 1424-8220, E-ISSN 1424-8220, Vol. 15, no 5, p. 11787-11804Article, review/survey (Refereed)
    Abstract [en]

    Recently ZnO has attracted much interest because of its usefulness for intracellular measurements of biochemical species by using its semiconducting, electrochemical, catalytic properties and for being biosafe and biocompatible. ZnO thus has a wide range of applications in optoelectronics, intracellular nanosensors, transducers, energy conversion and medical sciences. This review relates specifically to intracellular electrochemical (glucose and free metal ion) biosensors based on functionalized zinc oxide nanowires/nanorods. For intracellular measurements, the ZnO nanowires/nanorods were grown on the tip of a borosilicate glass capillary (0.7 mu m in diameter) and functionalized with membranes or enzymes to produce intracellular selective metal ion or glucose sensors. Successful intracellular measurements were carried out using ZnO nanowires/nanorods grown on small tips for glucose and free metal ions using two types of cells, human fat cells and frog oocytes. The sensors in this study were used to detect real-time changes of metal ions and glucose across human fat cells and frog cells using changes in the electrochemical potential at the interface of the intracellular micro-environment. Such devices are helpful in explaining various intracellular processes involving ions and glucose.

  • 313.
    Askari Ghotbabadi, Sadegh
    et al.
    Linköping University, Department of Physics, Chemistry and Biology, Plasma and Coating Physics. Linköping University, Faculty of Science & Engineering. University of Ulster, North Ireland.
    Ul Haq, Atta
    University of Ulster, North Ireland.
    Macias-Montero, Manuel
    University of Ulster, North Ireland.
    Levchenko, Igor
    Queensland University of Technology, Australia.
    Yu, Fengjiao
    University of St Andrews, Scotland.
    Zhou, Wuzong
    University of St Andrews, Scotland.
    (Ken) Ostrikov, Kostya
    Queensland University of Technology, Australia; Queensland University of Technology, Australia; CSIRO, Australia.
    Maguire, Paul
    University of Ulster, North Ireland.
    Svrcek, Vladimir
    National Institute Adv Ind Science and Technology, Japan.
    Mariotti, Davide
    University of Ulster, North Ireland.
    Ultra-small photoluminescent silicon-carbide nanocrystals by atmospheric-pressure plasmas2016In: Nanoscale, ISSN 2040-3364, E-ISSN 2040-3372, Vol. 8, no 39, p. 17141-17149Article in journal (Refereed)
    Abstract [en]

    Highly size-controllable synthesis of free-standing perfectly crystalline silicon carbide nanocrystals has been achieved for the first time through a plasma-based bottom-up process. This low-cost, scalable, ligand-free atmospheric pressure technique allows fabrication of ultra-small (down to 1.5 nm) nanocrystals with very low level of surface contamination, leading to fundamental insights into optical properties of the nanocrystals. This is also confirmed by their exceptional photoluminescence emission yield enhanced by more than 5 times by reducing the nanocrystals sizes in the range of 1-5 nm, which is attributed to quantum confinement in ultra-small nanocrystals. This method is potentially scalable and readily extendable to a wide range of other classes of materials. Moreover, this ligand-free process can produce colloidal nanocrystals by direct deposition into liquid, onto biological materials or onto the substrate of choice to form nanocrystal films. Our simple but efficient approach based on non-equilibrium plasma environment is a response to the need of most efficient bottom-up processes in nanosynthesis and nanotechnology.

  • 314.
    Askenberger, Erik
    Linköping University, Department of Computer and Information Science. Linköping University, Faculty of Science & Engineering.
    Hur är relationen mellan kommunikationen i en crowdfundingkampanj och dess utfall? En studie av glassprojekt i USA på kickstarter.2015Independent thesis Basic level (degree of Bachelor), 10,5 credits / 16 HE creditsStudent thesis
    Abstract [en]

    In this study previous research on the factors that contributed to successful crowdfunding campaigns have been compiled and a survey carried out on successful ice cream projects from kickstarter.com. Crowdfunding is a relative new way of collecting investment money; this is done by asking the public for small donation to raise a big amount and by that achieve the campaign goal. Communication in a crowdfunding campaign seems to have tremendous impact on a project’s success, and the conclusion from previous studies is that a project must be of high quality to do well. The result of the Ice Cream Projects analyzed indicated that the number of project updates correlates to the result. Video length does not correlate with the results and is not a measure of the campaign's quality. The number of private Facebook friends the creator of the project has affects campaign performance. The likely explanation is that the majority of donations is from friends and family, and these donations may be an indication to others that the project is serious and thus attracts the more donations.

  • 315.
    Asklund Andersson, Alexandra
    Linköping University, Department of Computer and Information Science. Linköping University, Faculty of Science & Engineering.
    Digitala spel och dyslexi2015Independent thesis Basic level (degree of Bachelor), 10,5 credits / 16 HE creditsStudent thesis
    Abstract [en]

    In the modern world there is a great emphasis on the individuals ability to partake in written information; however, as there is between 5% and 8% of the Swedish population that suffers from a learning disability, this can quickly become a problem. The fact that Dyslexia is hard to detect early on adds to the burden of those affected and can even lead to low self-esteem and failing motivation to study.

     

    Therefore, there is a need for new screening tools that can detect dyslexia early, an idea centered on a game for such a tool is what this study has chosen to focus on. The viability of such a game has been tried through a series of 16 qualitative interviews and 15 benchmarking analyses. The author makes the case for the requirement specification such a game based screening tool will have, what must be considered in its development, and how kids reflect upon games.

     

    The requirement specification presented in the results serves not only as a basis for a screening tool but also gives valuable insight into the opinions of children on the topic of gaming and provides the more practical suggestions for the tool itself.

  • 316.
    Asp, Filip
    et al.
    Linköping University, Department of Computer and Information Science. Linköping University, Faculty of Science & Engineering.
    Krispinsson, Tobias
    Linköping University, Department of Computer and Information Science. Linköping University, Faculty of Science & Engineering.
    Distributed certificates in ad hoc networks2015Independent thesis Basic level (degree of Bachelor), 10,5 credits / 16 HE creditsStudent thesis
    Abstract [en]

    In this report an ad hoc system is defined with the capabilities to validate the integrity ofevery node in the network without a third party, as long as every node has possession of acertificate. The system is developed to function in an ad hoc network with many externalthreats. The main target group would be the military and first responders. There are manydifferent problems with such a network, and many parts have been researched, but few fullsystems have been developed. This report defines a hierarchical system where nodes cancommunicate in an encrypted way, with the help of certificates. In a military situation therisk for compromised nodes must be considered. Therefore, the system can both detectand handle compromised nodes by revocation certificates. The proposed system is alsodetecting and handling partitions. The system has been put together by first making aliterature study to find existing solutions to different problems, then making a synthesisof those solutions. We also came up with new solutions where the three cornerstones ofsecurity: availability, confidentiality and integrity were in focus. To make the solutionmore trustworthy a risk analysis on the resulting system was made, which defined theweak points of the system.

  • 317.
    Asplund, Mikael
    Linköping University, Department of Computer and Information Science, Software and Systems. Linköping University, Faculty of Science & Engineering.
    Model-based Membership Verification in Vehicular Platoons2015In: Proceedings: 2015 45th Annual IEEE/IFIP International Conference on Dependable Systems and Networks Workshops , IEEE Computer Society, 2015, p. 125-132Conference paper (Refereed)
    Abstract [en]

    Cooperative vehicular systems have the potentialto significantly increase traffic efficiency and safety. However,they also raise the question of to what extent information thatis received from other vehicles can be trusted. In this paperwe present a novel approach for increasing the trustworthinessof cooperative driving through a model-based approach forverifying membership views in vehicular platoons. We define aformal model for platoon membership, cooperative awarenessclaims, and membership verification mechanisms. With the helpof a satisfiability solver, we are able to quantitatively analysethe impact of different system parameters on the verifiability ofreceived information. Our results demonstrate the importance ofcross validating received messages, as well as the surprising diffi-culty in establishing correct membership views despite powerfulverification mechanisms.

  • 318.
    Asplund, Mikael
    et al.
    Linköping University, Department of Computer and Information Science. Linköping University, Faculty of Science & Engineering.
    Lövhall, Jakob
    Linköping University, Department of Computer and Information Science, Software and Systems. Linköping University, Faculty of Science & Engineering.
    Villani, Emilia
    Auronatics Institute of Technology, Brazil.
    Specification, Implementation and Verification of Dynamic Group Membership for Vehicle Coordination2017In: Dependable Computing (PRDC), 2017 IEEE 22nd Pacific Rim International Symposium on, IEEE, 2017, p. 321-328Conference paper (Refereed)
    Abstract [en]

    New advanced traffic management solutions with fully or semi-autonomous vehicles that communicate over a wireless interface to coordinate their driving decisions create new challenges in distributed computing. In this paper we address the problem of dynamic group membership in three stages. First, we propose three criteria to specify correctness and performance of the group views created by such algorithms in terms of soundness, completeness and freshness. Second, we develop a group membership protocol tailored for vehicular coordination. Finally, we show through simulation and model-based verification that the protocol does indeed meet the criteria and provide at least 95% perfect group membership views under as adverse conditions as 70% packet loss or very high churn rate.

  • 319.
    Asplund, Mikael
    et al.
    Linköping University, Department of Computer and Information Science, Software and Systems. Linköping University, Faculty of Science & Engineering.
    Nadjm-Tehrani, Simin
    Linköping University, Department of Computer and Information Science, Software and Systems. Linköping University, Faculty of Science & Engineering.
    Attitudes and Perceptions of IoT Security in Critical Societal Services2016In: IEEE Access, E-ISSN 2169-3536, Vol. 4, p. 2130-2138Article in journal (Refereed)
    Abstract [en]

    A quiet revolution that impacts several sectors, ranging over transport, home automation, energy, industrial control, and health services is undergoing with addition of new networked devices leading to enhanced services. In this paper, we aim to identify information security requirements that are common over several (vertical) sectors, and in particular, ones that impact critical societal services, namely, the energy, water, and health management systems. We present the results of an interview-based study where actors in these sectors were asked about their perceptions and attitudes on the security of Internet of Things (IoT). We set these perceptions and attitudes in context through a literature review of IoT security, and relate to current challenges in this area. This paper demonstrates that despite an overall optimistic view on IoT in critical societal services, there is a lack of consensus on risks related to IoT security.

  • 320.
    Asratian, Armen
    et al.
    Linköping University, Department of Mathematics, Mathematics and Applied Mathematics. Linköping University, Faculty of Science & Engineering.
    Casselgren, Carl Johan
    Linköping University, Department of Mathematics, Mathematics and Applied Mathematics. Linköping University, Faculty of Science & Engineering. University of Southern Denmark, Denmark.
    Solution of Vizings Problem on Interchanges for the case of Graphs with Maximum Degree 4 and Related Results2016In: Journal of Graph Theory, ISSN 0364-9024, E-ISSN 1097-0118, Vol. 82, no 4, p. 350-373Article in journal (Refereed)
    Abstract [en]

    Let G be a Class 1 graph with maximum degree 4 and let t amp;gt;= 5 be an integer. We show that any proper t-edge coloring of G can be transformed to any proper 4-edge coloring of G using only transformations on 2-colored subgraphs (so-called interchanges). This settles the smallest previously unsolved case of a well-known problem of Vizing on interchanges, posed in 1965. Using our result we give an affirmative answer to a question of Mohar for two classes of graphs: we show that all proper 5-edge colorings of a Class 1 graph with maximum degree 4 are Kempe equivalent, that is, can be transformed to each other by interchanges, and that all proper 7-edge colorings of a Class 2 graph with maximum degree 5 are Kempe equivalent. (C) 2015 Wiley Periodicals, Inc.

  • 321.
    Asratian, Armen
    et al.
    Linköping University, Department of Mathematics, Mathematics and Applied Mathematics. Linköping University, Faculty of Science & Engineering.
    Casselgren, Carl Johan
    Linköping University, Department of Mathematics, Mathematics and Applied Mathematics. Linköping University, Faculty of Science & Engineering.
    Petrosyan, Petros A.
    Yerevan State University, Armenia; National Academic Science, Armenia.
    Some results on cyclic interval edge colorings of graphs2018In: Journal of Graph Theory, ISSN 0364-9024, E-ISSN 1097-0118, Vol. 87, no 2, p. 239-252Article in journal (Refereed)
    Abstract [en]

    A proper edge coloring of a graph G with colors 1,2,,t is called a cyclic interval t-coloring if for each vertex v of G the edges incident to v are colored by consecutive colors, under the condition that color 1 is considered as consecutive to color t. We prove that a bipartite graph G of even maximum degree (G)4 admits a cyclic interval (G)-coloring if for every vertex v the degree dG(v) satisfies either dG(v)(G)-2 or dG(v)2. We also prove that every Eulerian bipartite graph G with maximum degree at most eight has a cyclic interval coloring. Some results are obtained for (a,b)-biregular graphs, that is, bipartite graphs with the vertices in one part all having degree a and the vertices in the other part all having degree b; it has been conjectured that all these have cyclic interval colorings. We show that all (4, 7)-biregular graphs as well as all (2r-2,2r)-biregular (r2) graphs have cyclic interval colorings. Finally, we prove that all complete multipartite graphs admit cyclic interval colorings; this proves a conjecture of Petrosyan and Mkhitaryan.

    The full text will be freely available from 2018-05-30 12:31
  • 322.
    Atakan, Aylin
    et al.
    Linköping University, Department of Physics, Chemistry and Biology, Nanostructured Materials. Linköping University, Faculty of Science & Engineering.
    Mäkie, Peter
    Linköping University, Department of Physics, Chemistry and Biology, Nanostructured Materials. Linköping University, Faculty of Science & Engineering.
    Söderlind, Fredrik
    Linköping University, Department of Physics, Chemistry and Biology, Chemistry. Linköping University, Faculty of Science & Engineering.
    Keraudy, Julien
    Linköping University, Department of Physics, Chemistry and Biology, Plasma and Coating Physics. Linköping University, Faculty of Science & Engineering.
    Björk, Emma
    Linköping University, Department of Physics, Chemistry and Biology, Nanostructured Materials. Linköping University, Faculty of Science & Engineering.
    Odén, Magnus
    Linköping University, Department of Physics, Chemistry and Biology, Nanostructured Materials. Linköping University, Faculty of Science & Engineering.
    Synthesis of a Cu-infiltrated Zr-doped SBA-15 catalyst for CO2 hydrogenation into methanol and dimethyl ethert2017In: Physical Chemistry, Chemical Physics - PCCP, ISSN 1463-9076, E-ISSN 1463-9084, Vol. 19, no 29, p. 19139-19149Article in journal (Refereed)
    Abstract [en]

    A catalytically active nanoassembly comprising Cu-nanoparticles grown on integrated and active supports (large pore Zr-doped mesoporous SBA-15 silica) has been synthesized and used to promote CO2 hydrogenation. The doped mesoporous material was synthesized using a sal-gel method, in which the pore size was tuned between 11 and 15 nm while maintaining a specific surface area of about 700 m(2) g (1). The subsequent Cu nanoparticle growth was achieved by an infiltration process involving attachment of different functional groups on the external and internal surfaces of the mesoporous structure such that 7-10 nm sized Cu nanoparticles grew preferentially inside the pores. Chemisorption showed improved absorption of both CO2 and H-2 for the assembly compared to pure SBA-15 and 15% of the total CO2 was converted to methanol and dimethyl ether at 250 degrees C and 33 bar.

  • 323.
    Atikuzzaman, Mohammad
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences.
    Alvarez-Rodriguez, Manuel
    Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences.
    Carrillo, Alejandro Vicente
    Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences.
    Johnsson, Martin
    Linköping University, Department of Physics, Chemistry and Biology, Biology. Linköping University, Faculty of Science & Engineering.
    Wright, Dominic
    Linköping University, Department of Physics, Chemistry and Biology, Biology. Linköping University, Faculty of Science & Engineering.
    Rodriguez-Martinez, Heriberto
    Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences.
    Conserved gene expression in sperm reservoirs between birds and mammals in response to mating.2017In: BMC Genomics, ISSN 1471-2164, E-ISSN 1471-2164, Vol. 18, no 1Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Spermatozoa are stored in the oviductal functional sperm reservoir in animals with internal fertilization, including zoologically distant classes such as pigs or poultry. They are held fertile in the reservoir for times ranging from a couple of days (in pigs), to several weeks (in chickens), before they are gradually released to fertilize the newly ovulated eggs. It is currently unknown whether females from these species share conserved mechanisms to tolerate such a lengthy presence of immunologically-foreign spermatozoa. Therefore, global gene expression was assessed using cDNA microarrays on tissue collected from the avian utero-vaginal junction (UVJ), and the porcine utero-tubal junction (UTJ) to determine expression changes after mating (entire semen deposition) or in vivo cloacal/cervical infusion of sperm-free seminal fluid (SF)/seminal plasma (SP).

    RESULTS: In chickens, mating changed the expression of 303 genes and SF-infusion changed the expression of 931 genes, as compared to controls, with 68 genes being common to both treatments. In pigs, mating or SP-infusion changed the expressions of 1,722 and 1,148 genes, respectively, as compared to controls, while 592 genes were common to both treatments. The differentially expressed genes were significantly enriched for GO categories related to immune system functions (35.72-fold enrichment). The top 200 differentially expressed genes of each treatment in each animal class were analysed for gene ontology. In both pig and chicken, an excess of genes affecting local immune defence were activated, though frequently these were down-regulated. Similar genes were found in both the chicken and pig, either involved in pH-regulation (SLC16A2, SLC4A9, SLC13A1, SLC35F1, ATP8B3, ATP13A3) or immune-modulation (IFIT5, IFI16, MMP27, ADAMTS3, MMP3, MMP12).

    CONCLUSION: Despite being phylogenetically distant, chicken and pig appear to share some gene functions for the preservation of viable spermatozoa in the female reservoirs.

  • 324.
    Atikuzzaman, Mohammad
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences.
    Alvarez-Rodriguez, Manuel
    Linköping University, Department of Clinical and Experimental Medicine, Division of Children's and Women's health. Linköping University, Faculty of Medicine and Health Sciences.
    Vicente Carrillo, Alejandro
    Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences.
    Johnsson, Martin
    Linköping University, Department of Physics, Chemistry and Biology, Biology. Linköping University, Faculty of Science & Engineering.
    Wright, Dominic
    Linköping University, Department of Physics, Chemistry and Biology, Biology. Linköping University, Faculty of Science & Engineering.
    Rodriguez-Martinez, Heriberto
    Linköping University, Department of Clinical and Experimental Medicine, Division of Children's and Women's health. Linköping University, Faculty of Medicine and Health Sciences.
    Correction: Conserved gene expression in sperm reservoirs between birds and mammals in response to mating (vol 18, 98, 2017)2017In: BMC Genomics, ISSN 1471-2164, E-ISSN 1471-2164, Vol. 18, article id 563Article in journal (Refereed)
    Abstract [en]

    n/a

  • 325.
    Atikuzzaman, Mohammad
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences.
    Bhai Mehta, Ratnesh
    Linköping University, Faculty of Medicine and Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science.
    Fogelholm, Jesper
    Linköping University, Department of Physics, Chemistry and Biology, Biology. Linköping University, Faculty of Science & Engineering.
    Wright, Dominic
    Linköping University, Department of Physics, Chemistry and Biology, Biology. Linköping University, Faculty of Science & Engineering.
    Rodriguez-Martinez, Heriberto
    Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences.
    Mating induces the expression of immune- and pH-regulatory genes in the utero-vaginal junction containing mucosal sperm-storage tubuli of hens2015In: Reproduction, Vol. 150, no 6, p. 473-483Article in journal (Refereed)
    Abstract [en]

    The female chicken, as with other species with internal fertilization, can tolerate the presence of spermatozoa within specialized sperm-storage tubuli (SST) located in the mucosa of the utero-vaginal junction (UVJ) for days or weeks, without eliciting an immune response. To determine if the oviduct alters its gene expression in response to sperm entry, segments from the oviduct (UVJ, uterus, isthmus, magnum and infundibulum) of mated and unmated (control) hens, derived from an advanced inter-cross line between Red Junglefowl and White Leghorn, were explored 24 h after mating using cDNA microarray analysis. Mating shifted the expression of fifteen genes in the UVJ (53.33% immune-modulatory and 20.00% pH-regulatory) and seven genes in the uterus, none of the genes in the latter segment overlapping the former (with the differentially expressed genes themselves being less related to immune-modulatory function). The other oviductal segments did not show any significant changes. These findings suggest sperm deposition causes a shift in expression in the UVJ (containing mucosal SST) and the uterus for genes involved in immune-modulatory and pH-regulatory functions, both relevant for sperm survival in the hen's oviduct.

  • 326.
    Atikuzzaman, Mohammad
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences.
    Sanz, Libia
    Instituto de Biomedicina de Valencia, CSIC, Valencia, Spain.
    Pla, Davinia
    Instituto de Biomedicina de Valencia, CSIC, Valencia, Spain.
    Alvarez-Rodriguez, Manuel
    Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences.
    Rubér, Marie
    Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences.
    Wright, Dominic
    Linköping University, Department of Physics, Chemistry and Biology, Biology. Linköping University, Faculty of Science & Engineering.
    Calvete, Juan J.
    Instituto de Biomedicina de Valencia, CSIC, Valencia, Spain.
    Rodriguez-Martinez, Heriberto
    Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences.
    Selection for higher fertility reflects in the seminal fluid proteome of modern domestic chicken2017In: Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics, ISSN 1744-117X, E-ISSN 1878-0407, Vol. 21, p. 27-40Article in journal (Refereed)
    Abstract [en]

    The high egg-laying capacity of the modern domestic chicken (i.e. White Leghorn, WL) has arisen from the low egg-laying ancestor Red Junglefowl (RJF) via continuous trait selection and breeding. To investigate whether this long-term selection impacted the seminal fluid (SF)-proteome, 2DE electrophoresis-based proteomic analyses and immunoassays were conducted to map SF-proteins/cytokines in RJF, WL and a 9th generation Advanced Intercross Line (AIL) of RJF/WL-L13, including individual SF (n = 4, from each RJF, WL and AIL groups) and pools of the SF from 15 males of each group, analyzed by 2DE to determine their degree of intra-group (AIL, WL, and RJF) variability using Principal Component Analysis (PCA); respectively an inter-breed comparative analysis of intergroup fold change of specific SF protein spots intensity between breeds. The PCA clearly highlighted a clear intra-group similarity among individual roosters as well as a clear inter-group variability (e.g. between RJF, WL and AIL) validating the use of pools to minimize confounding individual variation. Protein expression varied considerably for processes related to sperm motility, nutrition, transport and survival in the female, including signaling towards immunomodulation. The major conserved SF-proteins were serum albumin and ovotransferrin. Aspartate aminotransferase, annexin A5, arginosuccinate synthase, glutathione S-transferase 2 and l-lactate dehydrogenase-A were RJF-specific. Glyceraldehyde-3-phosphate dehydrogenase appeared specific to the WL-SF while angiotensin-converting enzyme, γ-enolase, coagulation factor IX, fibrinogen α-chain, hemoglobin subunit α-D, lysozyme C, phosphoglycerate kinase, Src-substrate protein p85, tubulins and thioredoxin were AIL-specific. The RJF-SF contained fewer immune system process proteins and lower amounts of the anti-inflammatory/immunomodulatory TGF-β2 compared to WL and AIL, which had low levels- or lacked pro-inflammatory CXCL10 compared to RJF. The seminal fluid proteome differs between ancestor and modern chicken, with a clear enrichment of proteins and peptides related to immune-modulation for sperm survival in the female and fertility.

  • 327.
    Atxabal, Ainhoa
    et al.
    CIC NanoGUNE, Spain.
    Braun, Slawomir
    Linköping University, Department of Physics, Chemistry and Biology, Surface Physics and Chemistry. Linköping University, Faculty of Science & Engineering.
    Arnold, Thorsten
    Technical University of Dresden, Germany.
    Sun, Xiangnan
    National Centre Nanosci and Technology, Peoples R China.
    Parui, Subir
    CIC NanoGUNE, Spain.
    Liu, Xianjie
    Linköping University, Department of Physics, Chemistry and Biology, Surface Physics and Chemistry. Linköping University, Faculty of Science & Engineering.
    Gozalvez, Cristian
    University of Basque Country UPV EHU, Spain.
    Llopis, Roger
    CIC NanoGUNE, Spain.
    Mateo-Alonso, Aurelio
    University of Basque Country UPV EHU, Spain; Basque Fdn Science, Spain.
    Casanova, Felix
    CIC NanoGUNE, Spain; Basque Fdn Science, Spain.
    Ortmann, Frank
    Technical University of Dresden, Germany.
    Fahlman, Mats
    Linköping University, Department of Physics, Chemistry and Biology, Surface Physics and Chemistry. Linköping University, Faculty of Science & Engineering.
    Hueso, Luis E.
    CIC NanoGUNE, Spain; Basque Fdn Science, Spain.
    Energy Level Alignment at Metal/Solution-Processed Organic Semiconductor Interfaces2017In: Advanced Materials, ISSN 0935-9648, E-ISSN 1521-4095, Vol. 29, no 19, article id 1606901Article in journal (Refereed)
    Abstract [en]

    Energy barriers between the metal Fermi energy and the molecular levels of organic semiconductor devoted to charge transport play a fundamental role in the performance of organic electronic devices. Typically, techniques such as electron photoemission spectroscopy, Kelvin probe measurements, and in-device hot-electron spectroscopy have been applied to study these interfacial energy barriers. However, so far there has not been any direct method available for the determination of energy barriers at metal interfaces with n-type polymeric semiconductors. This study measures and compares metal/solution-processed electron-transporting polymer interface energy barriers by in-device hot-electron spectroscopy and ultraviolet photoemission spectroscopy. It not only demonstrates in-device hot-electron spectroscopy as a direct and reliable technique for these studies but also brings it closer to technological applications by working ex situ under ambient conditions. Moreover, this study determines that the contamination layer coming from air exposure does not play any significant role on the energy barrier alignment for charge transport. The theoretical model developed for this work confirms all the experimental observations.

  • 328.
    Augusto Berrocal, Jose
    et al.
    Eindhoven University of Technology, Netherlands.
    Di Meo, Florent
    Linköping University, Department of Physics, Chemistry and Biology, Theoretical Chemistry. Linköping University, Faculty of Science & Engineering. University of Limoges, France.
    Garcia-Iglesias, Miguel
    Eindhoven University of Technology, Netherlands.
    Gosens, Ronald P. J.
    Eindhoven University of Technology, Netherlands.
    Meijer, E. W.
    Eindhoven University of Technology, Netherlands.
    Linares, Mathieu
    Linköping University, Department of Physics, Chemistry and Biology, Bioinformatics. Linköping University, Faculty of Science & Engineering.
    Palmans, Anja R. A.
    Eindhoven University of Technology, Netherlands.
    Consequences of conformational flexibility in hydrogen-bond-driven self-assembly processes2016In: Chemical Communications, ISSN 1359-7345, E-ISSN 1364-548X, Vol. 52, no 72, p. 10870-10873Article in journal (Refereed)
    Abstract [en]

    We report the synthesis and self-assembly of chiral, conformationally flexible C-3-symmetrical trisamides. A strong Cotton effect is observed for the supramolecular polymers in linear alkanes but not in cyclic alkanes. MD simulations suggest 2:1 conformations of the amides within the aggregates in both types of solvents, but a chiral bias in only linear alkanes.

  • 329.
    Avgouleas, Ioannis
    Linköping University, Department of Science and Technology, Communications and Transport Systems. Linköping University, Faculty of Science & Engineering.
    IoT Networking Resource Allocation and Cooperation2017Licentiate thesis, comprehensive summary (Other academic)
    Abstract [en]

    The Internet of Things (IoT) promises that "anything that can be connected, will be connected". It comprises of Information and Communication Technologies that interconnect billions of physical and visual things with some "basic" intelligence. The emerging IoT services will be able to react with minimal human intervention and further contribute to the big data era that requires real-time, ultrareliable, ubiquitous, scalable, and heterogeneous operation.

    This thesis is the result of our investigations on problems dealing with the evolution of such technologies. First, we explore the potential of using relay i.e., intermediate, nodes that assist users to transmit their packets in a a cellular network. Paper I provides insights into how adapting the cooperation of the relay's receiver and transmitter optimizes the network-wide throughput while the relay's queue stability is guaranteed.

    The next part of the thesis copes with the resource allocation of services on IoT devices equipped with multiple network interfaces. The resources are heterogeneous and can be split among dierent interfaces. Additionally, they are not interchangeable. In paper II, we develop optimization models for this resource allocation problem, prove the complexity of the models, and derive results that give intuition into the problems. Moreover, we propose algorithms that approximate the optimal solution and show under which circumstances this is possible.

    Finally, in paper III, we present a resource allocation problem specically for smart cities services. In comparison to the previous problem denition, resources are of one type but the IoT network device can oer capacities that vary over time. Furthermore, services have a tolerance regarding their preferred scheduling, namely, their allocation over time. We parametrize each service with a pricing function to indicate its tolerance to be served at the beginning of the scheduling window. We prove that the problem is computationally hard and provide numerical results to gain insight into how different pricing weight functions impact the allocations' distribution within the scheduling window.

  • 330.
    Avgouleas, Ioannis
    et al.
    Linköping University, Department of Science and Technology, Communications and Transport Systems. Linköping University, Faculty of Science & Engineering.
    Angelakis, Vangelis
    Linköping University, Department of Science and Technology, Communications and Transport Systems. Linköping University, Faculty of Science & Engineering.
    Pappas, Nikolaos
    Linköping University, Department of Science and Technology, Communications and Transport Systems. Linköping University, Faculty of Science & Engineering.
    Utilizing multiple full-duplex relays in wireless systems with multiple packet reception2014In: 2014 IEEE 19th International Workshop on Computer Aided Modeling and Design of Communication Links and Networks (CAMAD), 2014, p. 193-197Conference paper (Refereed)
    Abstract [en]

    Relay nodes with physical layer cooperation have been used extensively to assist users' transmissions in wireless networks. This network level cooperation has been lately been gaining popularity and analytical expressions of the performance of a network with up to two relay nodes exist in recent literature. In this work, we give simulation results outlining the potential network level benefits of using multiple full-duplex relay nodes. We examine configurations where multiple full-duplex transceivers offer consistent improvement and provide guidelines on using them different network conditions.

  • 331.
    Avgouleas, Ioannis
    et al.
    Linköping University, Department of Science and Technology, Communications and Transport Systems. Linköping University, Faculty of Science & Engineering.
    Pappas, Nikolaos
    Linköping University, Department of Science and Technology, Communications and Transport Systems. Linköping University, Faculty of Science & Engineering.
    Angelakis, Vangelis
    Linköping University, Department of Science and Technology, Communications and Transport Systems. Linköping University, Faculty of Science & Engineering.
    Cooperative Wireless Networking with Probabilistic On/Off Relaying2015In: 2015 IEEE 81ST VEHICULAR TECHNOLOGY CONFERENCE (VTC SPRING), IEEE , 2015Conference paper (Refereed)
    Abstract [en]

    In this work, we investigate the operation of energy efficient relay nodes assisting the transmission of packets from a number of users to a destination node. We study the impact of switching randomly a fraction of the relays on and off to the aggregate throughput, the average queue size and delay per packet of systems with relays transmitting in either Full-or Half-Duplex mode and under different channel transmissions characteristics. Furthermore, we prove analytically and illustrate via simulation means how these network metrics are affected.

  • 332.
    Avgouleas, Ioannis
    et al.
    Linköping University, Department of Science and Technology, Communications and Transport Systems. Linköping University, Faculty of Science & Engineering.
    Pappas, Nikolaos
    Linköping University, Department of Science and Technology, Communications and Transport Systems. Linköping University, Faculty of Science & Engineering.
    Angelakis, Vangelis
    Linköping University, Department of Science and Technology, Communications and Transport Systems. Linköping University, Faculty of Science & Engineering.
    Scheduling Services on an IoT Device Under Time-Weighted Pricing2017In: IEEE 28th Annual International Symposium on Personal, Indoor, and Mobile Radio Communications (PIMRC): Workshop on "Communications for Networked Smart Cities", IEEE conference proceedings, 2017Conference paper (Refereed)
    Abstract [en]

    The emerging vision of smart cities necessitates the use of Internet of Things (IoT) network devices to implement sustainable solutions that will improve the operations of urban areas. A massive amount of smart cities services may demand allocation of computational resources, such as processing power or storage, that IoT devices offer. Within this context, we present an IoT network device comprising interfaces with one specific computational resource available. The efficient utilization of available IoT resources would improve the Quality of Service (QoS) of the IoT network that serves the smart city. All resource allocations must be completed within a given scheduling window and every service is parametrized by a pricing weight function to indicate its tolerance to be served at the beginning of the scheduling window. We propose a mathematical optimization formulation to minimize the total cost of allocating all demands within the scheduling window considering the tolerance level of each service at the same time. Moreover, we prove that the problem is computationally hard and we provide numerical results to gain insight into the impact of different pricing weight functions on the allocations’ distribution within the scheduling window.

  • 333.
    Avgouleas, Ioannis
    et al.
    Linköping University, Department of Science and Technology, Communications and Transport Systems. Linköping University, Faculty of Science & Engineering.
    Pappas, Nikolaos
    Linköping University, Department of Science and Technology, Communications and Transport Systems. Linköping University, Faculty of Science & Engineering.
    Yuan, Di
    Linköping University, Department of Science and Technology, Communications and Transport Systems. Linköping University, Faculty of Science & Engineering.
    Angelakis, Vangelis
    Linköping University, Department of Science and Technology, Communications and Transport Systems. Linköping University, Faculty of Science & Engineering.
    Probabilistic Cooperation of a Full-Duplex Relay in Random Access Networks2017In: IEEE Access, E-ISSN 2169-3536, Vol. 5, p. 7394-7404Article in journal (Refereed)
    Abstract [en]

    In this paper, we analyze the probabilistic cooperation of a full-duplex relay in a multiuser random-access network. The relay is equipped with on/off modes for the receiver and the transmitter independently. These modes are modeled as probabilities by which the receiver and the transmitter are activated. We provide analytical expressions for the performance of the relay queue, such as arrival and service rates, stability conditions, and the average queue size. We optimize the relays operation setup to maximize the network-wide throughput while, simultaneously, we keep the relays queue stable and lower the relays receptions and transmissions. Furthermore, we study the effect of the SINR threshold and the self-interference coefficient on the per-user and network-wide throughput. For low SINR threshold, we show under which circumstances it is beneficial to switch off the relay completely, or switch off the relays receiver only.

  • 334.
    Ax, Christian
    et al.
    Handelshögskolan vid Göteborgs universitet, Göteborg.
    Cöster, Mathias
    Linköping University, Department of Management and Engineering, Industrial Economics. Linköping University, Faculty of Science & Engineering.
    Iveroth, Einar
    Företagsekonomiska institutionen, Uppsala universitet, Uppsala.
    Strategisk prissättning: sambandet mellan strategi, prismodeller och kostnadskalkyler2016In: Strategisk ekonomistyrning: med dialog i fokus / [ed] Fredrik Nilsson, Carl-Johan Petri, Alf Westelius, Lund: Studentlitteratur AB, 2016, p. 123-154Chapter in book (Other academic)
  • 335.
    Axell, Erik
    et al.
    Dept. of Robust Telecommunications, Swedish Defence Research Agency, Sweden .
    Larsson, Erik G
    Linköping University, Department of Electrical Engineering, Communication Systems. Linköping University, Faculty of Science & Engineering.
    Persson, Daniel
    Linköping University, Department of Electrical Engineering, Communication Systems. Linköping University, Faculty of Science & Engineering.
    GNSS spoofing detection using multiple mobile COTS receivers2015In: ICASSP, IEEE International Conference on Acoustics, Speech and Signal Processing - Proceedings, Institute of Electrical and Electronics Engineers (IEEE), 2015, p. 3192-3196Conference paper (Refereed)
    Abstract [en]

    In this paper we deal with spoofing detection in GNSS receivers. We derive the optimal genie detector when the true positions are perfectly known, and the observation errors are Gaussian, as a benchmark for other detectors. The system model considers three dimensional positions, and includes correlated errors. In addition, we propose several detectors that do not need any position knowledge, that outperform recently proposed detectors in many interesting cases.

  • 336.
    Axelsson, Emil
    et al.
    Linköping University, Department of Science and Technology, Media and Information Technology. Linköping University, Faculty of Science & Engineering.
    Costa, Jonathas
    NYU, NY 10003 USA.
    Silva, Claudio
    NYU, NY 10003 USA.
    Emmart, Carter
    Amer Museum Nat Hist, NY 10024 USA.
    Bock, Alexander
    Linköping University, Department of Science and Technology. Linköping University, Faculty of Science & Engineering.
    Ynnerman, Anders
    Linköping University, Department of Science and Technology, Media and Information Technology. Linköping University, Faculty of Science & Engineering. Linköping University, Center for Medical Image Science and Visualization (CMIV).
    Dynamic Scene Graph: Enabling Scaling, Positioning, and Navigation in the Universe2017In: Computer graphics forum (Print), ISSN 0167-7055, E-ISSN 1467-8659, Vol. 36, no 3, p. 459-468Article in journal (Refereed)
    Abstract [en]

    In this work, we address the challenge of seamlessly visualizing astronomical data exhibiting huge scale differences in distance, size, and resolution. One of the difficulties is accurate, fast, and dynamic positioning and navigation to enable scaling over orders of magnitude, far beyond the precision of floating point arithmetic. To this end we propose a method that utilizes a dynamically assigned frame of reference to provide the highest possible numerical precision for all salient objects in a scene graph. This makes it possible to smoothly navigate and interactively render, for example, surface structures on Mars and the Milky Way simultaneously. Our work is based on an analysis of tracking and quantification of the propagation of precision errors through the computer graphics pipeline using interval arithmetic. Furthermore, we identify sources of precision degradation, leading to incorrect object positions in screen-space and z-fighting. Our proposed method operates without near and far planes while maintaining high depth precision through the use of floating point depth buffers. By providing interoperability with order-independent transparency algorithms, direct volume rendering, and stereoscopy, our approach is well suited for scientific visualization. We provide the mathematical background, a thorough description of the method, and a reference implementation.

    The full text will be freely available from 2018-07-01 14:42
  • 337.
    Axin, Mikael
    Linköping University, Department of Management and Engineering, Fluid and Mechatronic Systems. Linköping University, Faculty of Science & Engineering.
    Mobile Working Hydraulic System Dynamics2015Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    This thesis deals with innovative working hydraulic systems for mobile machines. Flow control systems are studied as an alternative to load sensing. The fundamental difference is that the pump is controlled based on the operator’s command signals rather than feedback signals from the loads. This control approach enables higher energy efficiency and there is no load pressure feedback causing stability issues. Experimental results show a reduced pump pressure margin and energy saving potential for a wheel loader application.

    The damping contribution from the inlet and outlet orifice in directional valves is studied. Design rules are developed and verified by experiments.

    A novel system architecture is proposed where flow control, load sensing and open-centre are merged into a generalized system description. The proposed system is configurable and the operator can realize the characteristics of any of the standard systems without compromising energy efficiency. This can be done non-discretely on-the-fly. Experiments show that it is possible to avoid unnecessary energy losses while improving system response and increasing stability margins compared to load sensing. Static and dynamic differences between different control modes are also demonstrated experimentally.

  • 338.
    Azahar Ali, Md.
    et al.
    CSIR, India; Indian Institute Technology Hyderabad, India.
    Srivastava, Saurabh
    CSIR, India; Delhi Technology University, India.
    Agrawal, Ved V.
    CSIR, India.
    Willander, Magnus
    Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, Faculty of Science & Engineering.
    John, Renu
    Indian Institute Technology Hyderabad, India.
    Malhotra, Bansi D.
    Delhi Technology University, India.
    A biofunctionalized quantum dot-nickel oxide nanorod based smart platform for lipid detection2016In: Journal of materials chemistry. B, ISSN 2050-750X, E-ISSN 2050-7518, Vol. 4, no 15, p. 2706-2714Article in journal (Refereed)
    Abstract [en]

    A reagent-free, low-cost and sensitive immunosensor has been fabricated using anti-apolipoprotein B (AAB) conjugated L-cysteine in situ capped cadmium sulfide quantum dots (CysCdS QDs) bound to nickel oxide nanorods (nNiO) for detection of low density lipoprotein (LDL) molecules in human serum samples. The structural and morphological properties of AAB conjugated CysCdS QDs and nNiO have been investigated using electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy and UV-visible techniques. In this immunosensor, the synthesized NiO nanorods act as mediators that allow the direct electron transfer due to their channeling effect resulting in a mediator-free biosensor. This mediator-free CysCdS-NiO based immunosensor shows improved characteristics such as a good sensitivity of 32.08 mu A (mg dl(-1))(-1) cm(-2) compared to that based on nNiO (1.42 mA (mg dl(-1))(-1) cm(-2)) alone for detection of lipid (LDL) molecules over a wide concentration range, 5-120 mg dl(-1) (0.015-0.36 mu M). The kinetic analysis yields an association constant (K-a) of 3.24 kM(-1) s(-1), indicating that the antibody conjugated CysCdS-NiO platform has a strong affinity towards lipid molecules. The excellent electron transport properties of the CysCdS-NiO nanocomposite in this immunosensor reveal that it provides an efficient platform for routine quantification of LDL molecules in real samples.

  • 339.
    Aziz Abdulla, Parosh
    et al.
    Uppsala University, Sweden.
    Faouzi Atig, Mohamed
    Uppsala University, Sweden.
    Chen, Yu-Fang
    Academic Sinica, Taiwan.
    Holik, Lukas
    Brno University of Technology, Czech Republic.
    Rezine, Ahmed
    Linköping University, Department of Computer and Information Science, Software and Systems. Linköping University, Faculty of Science & Engineering.
    Rummer, Philipp
    Uppsala University, Sweden.
    Stenman, Jari
    Uppsala University, Sweden.
    Norn: An SMT Solver for String Constraints2015In: COMPUTER AIDED VERIFICATION, PT I / [ed] Kroening, Daniel, Păsăreanu, Corina S., SPRINGER-VERLAG BERLIN , 2015, Vol. 9206, p. 462-469Conference paper (Refereed)
    Abstract [en]

    We present version 1.0 of the Norn SMT solver for string constraints. Norn is a solver for an expressive constraint language, including word equations, length constraints, and regular membership queries. As a feature distinguishing Norn from other SMT solvers, Norn is a decision procedure under the assumption of a set of acyclicity conditions on word equations, without any restrictions on the use of regular membership.

  • 340.
    Aziz Abdulla, Parosh
    et al.
    Uppsala University, Sweden.
    Faouzi Atig, Mohamed
    Uppsala University, Sweden.
    Chen, Yu-Fang
    Academic Sinica, Taiwan.
    Phi Diep, Bui
    Uppsala University, Sweden.
    Holik, Lukas
    Brno University of Technology, Czech Republic.
    Rezine, Ahmed
    Linköping University, Department of Computer and Information Science, Software and Systems. Linköping University, Faculty of Science & Engineering.
    Rummer, Philipp
    Uppsala University, Sweden.
    Flatten and Conquer A Framework for Efficient Analysis of String Constraints2017In: ACM SIGPLAN NOTICES, ASSOC COMPUTING MACHINERY , 2017, Vol. 52, no 6, p. 602-617Conference paper (Refereed)
    Abstract [en]

    We describe a uniform and efficient framework for checking the satisfiability of a large class of string constraints. The framework is based on the observation that both satisfiability and unsatisfiability of common constraints can be demonstrated through witnesses with simple patterns. These patterns are captured using flat automata each of which consists of a sequence of simple loops. We build a Counter-Example Guided Abstraction Refinement (CEGAR) framework which contains both an under-and an over-approximation module. The flow of information between the modules allows to increase the precision in an automatic manner. We have implemented the framework as a tool and performed extensive experimentation that demonstrates both the generality and efficiency of our method.

  • 341.
    Aziz Abdulla, Parosh
    et al.
    Uppsala University, Sweden.
    Haziza, Frederic
    Uppsala University, Sweden.
    Holik, Lukas
    Uppsala University, Sweden; Brno University of Technology, Czech Republic.
    Jonsson, Bengt
    Uppsala University, Sweden.
    Rezine, Ahmed
    Linköping University, Department of Computer and Information Science, Software and Systems. Linköping University, Faculty of Science & Engineering.
    An integrated specification and verification technique for highly concurrent data structures for highly concurrent data structures2017In: International Journal on Software Tools for Technology Transfer (STTT), ISSN 1433-2779, E-ISSN 1433-2787, Vol. 19, no 5, p. 549-563Article in journal (Refereed)
    Abstract [en]

    We present a technique for automatically verifying safety properties of concurrent programs, in particular programs that rely on subtle dependencies of local states of different threads, such as lock-free implementations of stacks and queues in an environment without garbage collection. Our technique addresses the joint challenges of infinite-state specifications, an unbounded number of threads, and an unbounded heap managed by explicit memory allocation. Our technique builds on the automata-theoretic approach to model checking, in which a specification is given by an automaton that observes the execution of a program and accepts executions that violate the intended specification. We extend this approach by allowing specifications to be given by a class of infinite-state automata. We show how such automata can be used to specify queues, stacks, and other data structures, by extending a data-independence argument. For verification, we develop a shape analysis, which tracks correlations between pairs of threads, and a novel abstraction to make the analysis practical. We have implemented our method and used it to verify programs, some of which have not been verified by any other automatic method before.

  • 342.
    Azoidou, Eva
    et al.
    ABB Corporate Research, Västerås Sweden.
    Pang, Zhibo
    Corporate Research, ABB AB, Västerås Sweden.
    Liu, Yu
    Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, Faculty of Science & Engineering.
    Lan, Dapeng
    ABB Corporate Research Center Sweden, Västerås, Sweden.
    Bag, Gargi
    Industrial Communication, ABB,Västerås Sweden.
    Gong, Shaofang
    Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, Faculty of Science & Engineering.
    Battery Lifetime Modeling and Validation of Wireless Building Automation Devices in Thread2017In: IEEE Transactions on Industrial Informatics, ISSN 1551-3203, E-ISSN 1941-0050, no 99Article in journal (Refereed)
    Abstract [en]

    The need for energy efficiency in wireless communication is prevalent in all areas, but to an even greater extent in low-power and lossy networks (LLN) that rely on resource constrained devices. This article seeks to address the problem of modeling the battery lifetime of a duty-cycled node, participating in a wireless sensor network that is typically used in smart home and building applications. Modeling in MATLAB and experimentation with prototype testing are employed to predict and validate. Various scenarios including sleepy end devices in a wireless sensor network are modeled and validated. They range from variable wake-up frequency and packet payload transmission to increasing network contention with the addition of network load. A comprehensive analysis of the main factors contributing to wasteful energy usage is provided. It can be concluded that the model can estimate the battery lifetime under different testing scenarios with an error rate less than 5 %.

  • 343.
    Azzouzi, Sawsen
    et al.
    University of Sousse, Tunisia.
    Ben Ali, M
    University of Sousse, Tunisia.
    Abbas, M.N.
    Analytical Laboratory, National Research Center, Egypt.
    Bala, C
    University of Bucharest, Romania.
    Dridi, C
    University of Sousse, Tunisia.
    Errachid, A
    University of Lyon, France.
    Turner, Anthony
    Linköping University, Department of Physics, Chemistry and Biology, Biosensors and Bioelectronics. Linköping University, Faculty of Science & Engineering.
    Electrochemical detection of cancer biomarkers using nano-materials based sensors as early warning system of prostate cancer2016In: Cancer Diagnostics Symposium, Swedish Exhibition and Congres Centre, Gothenburg, Sweden, 28 May 2016, Elsevier, 2016Conference paper (Other academic)
  • 344.
    Azzouzi, Sawsen
    et al.
    Linköping University, Department of Physics, Chemistry and Biology, Biosensors and Bioelectronics. Linköping University, Faculty of Science & Engineering. University of sousse, Tunisia.
    Kor, Kalamodin
    Linköping University, Department of Physics, Chemistry and Biology, Biosensors and Bioelectronics. Linköping University, Faculty of Science & Engineering. Damghan University, Iran.
    Ben Ali, Mounir
    University of sousse, Tunisia.
    Turner, Anthony
    Linköping University, Department of Physics, Chemistry and Biology, Biosensors and Bioelectronics. Linköping University, Faculty of Science & Engineering.
    Mak, Wing Cheung
    Linköping University, Department of Physics, Chemistry and Biology, Biosensors and Bioelectronics. Linköping University, Faculty of Science & Engineering.
    Beni, Valerio
    Linköping University, Department of Physics, Chemistry and Biology, Biosensors and Bioelectronics. Linköping University, Faculty of Science & Engineering.
    A single probe based impedimetric biosensor for the label free, real time monitoring of microRNA-21 biomarker2016In: Biosensors 2016 – The World Congress on Biosensors, Gothenburg, Sweden, 25-27 May 2016, Elsevier, 2016Conference paper (Other academic)
  • 345.
    Azzouzi, Sawsen
    et al.
    Linköping University, Department of Physics, Chemistry and Biology, Biosensors and Bioelectronics. Linköping University, Faculty of Science & Engineering. University of Sousse, Tunisia.
    Mak, Wing Cheung
    Linköping University, Department of Physics, Chemistry and Biology, Biosensors and Bioelectronics. Linköping University, Faculty of Science & Engineering.
    Kor, Kamalodin
    Linköping University, Department of Physics, Chemistry and Biology, Biosensors and Bioelectronics. Linköping University, Faculty of Science & Engineering. Iranian National Institute Oceanog and Atmospher Science, Iran.
    Turner, Anthony
    Linköping University, Department of Physics, Chemistry and Biology, Biosensors and Bioelectronics. Linköping University, Faculty of Science & Engineering.
    Ben Ali, Mounir
    University of Sousse, Higher Institute of Applied Sciences and Technology of Sousse, GREENS-ISSAT, Cité Ettafala, 4003 Ibn Khaldoun Sousse, Tunisia.
    Beni, Valerio
    Linköping University, Department of Physics, Chemistry and Biology. Linköping University, Faculty of Science & Engineering. ACREO SWEDISH ICE AB, Sweden.
    An integrated dual functional recognition/amplification bio-label for the one-step impedimetric detection of Micro-RNA-212017In: Biosensors & bioelectronics, ISSN 0956-5663, E-ISSN 1873-4235, Vol. 92, p. 154-161Article in journal (Refereed)
    Abstract [en]

    Alteration in expression of miRNAs has been correlated with different cancer types, tumour stage and response to treatments. In this context, a structurally responsive oligonucleotide-based electrochemical impedimetric biosensor has been developed for the simple and sensitive detection of miRNA-21. A highly specific biotinylated DNA/LNA molecular beacon (MB) probe was conjugated with gold nanoparticles (AuNPs) to create an integrated, dual function bio-label (biotin-MB-AuNPs) for both biorecognition and signal generation. In the presence of target miRNA-21, hybridisation takes place resulting in the "activation" of the biotin-MB; this event makes the biotin group, which was previously "protected" by the steric hindrance of the MB stem-loop structure, accessible. The activated biotin-MB-AuNPs/miRNA complexes become available for capture, via supramolecular interaction, onto a nentravidin-modified electrode for electrochemical transduction. The binding event results in a decrease of the charge transfer resistance at the working electrode/electrolyte interface. The biosensor responded linearly in the range 1-1000 pM of miRNA-21, with a limit of detection of 0.3 pM, good reproducibility (Relative Standard deviation (RSD) =3.3%) and high selectivity over other miRNAs (i.e. miRNA221 and miRNA-205) sequences. Detection of miRNA-21 in spiked serum samples at clinically relevant levels (low pM range) was also demonstrated, thus illustrating the potential of the biosensor for point-of-care clinical applications. The proposed biosensor design, based on the combination of a neutravidin transducing surface and the dual-function biotin-MB-AuNPs bio-label, provides a simple and robust approach for detection of short-length nucleic acid targets, such as miRNAs.

    The full text will be freely available from 2019-02-10 10:23
  • 346.
    Azzouzi, Sawsen
    et al.
    University of Sousse, Tunisia.
    Patra, Hirak Kumar
    Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Medicine and Health Sciences.
    Ben Ali, Mounir
    University of Sousse, Tunisia.
    Nooredeen Abbas, Mohammed
    National Research Centre, Egypt.
    Dridi, Cherif
    Centre Research Microelect and Nanotechnol CRMN Sousse, Tunisia.
    Errachid, Abdelhamid
    University of Lyon 1, France.
    Turner, Anthony
    Linköping University, Department of Physics, Chemistry and Biology, Biosensors and Bioelectronics. Linköping University, Faculty of Science & Engineering.
    Citrate-selective electrochemical mu-sensor for early stage detection of prostate cancer2016In: Sensors and actuators. B, Chemical, ISSN 0925-4005, E-ISSN 1873-3077, Vol. 228, p. 335-346Article in journal (Refereed)
    Abstract [en]

    The extremely specialised anatomical function of citrate inside the prostate, make it one of the preferred biomarkers for early stage detection of prostate cancer. However, current detection methods are seriously limited due to the very low citrate concentrations that need to be measured in order to follow disease progression. In the present work, we report a novel citrate-selective-sensor based on iron (III) phthalocyanine chloride-C-monoamido-Poly-n-Butyl Acrylate (Fe(III)MAPcC1 P n BA) modified gold -electrodes for the electrochemical determination and estimation of the pathophysiological range of citrate. The newly synthesised ionophore has been structurally characterised using Fourier transform infrared (FTIR) and UV-vis spectroscopy. Contact angle measurements and atomic force microscopy (AFM) have been used to investigate the adhesion and morphological properties of the membrane. The developed citrate-selective-electrodes had a Nernstian sensitivity of-19.34 +/- 0.83 mV/decade with a detection limit of about 9 x 10-6M and a linear range from 4 x 10(-5)M to 10(-1) M, which covered the pathologically important clinical range. Electrochemical impedance spectroscopy (EIS) showed very high sensitivity with a lower Limit of detection 1.7 x 10(-9) M and linear detection range (10(-8)-10(-1) M), which is very important not only for the early-stage diagnosis and screening procedures, but also in mapping the stage of the cancer too. (C) 2016 Elsevier B.V. All rights reserved.

  • 347.
    Baas, Leenard
    et al.
    Linköping University, Department of Management and Engineering, Environmental Technology and Management. Linköping University, Faculty of Science & Engineering.
    Hjelm, Olof
    Linköping University, Department of Management and Engineering, Environmental Technology and Management. Linköping University, Faculty of Science & Engineering.
    Support your future today: enhancing sustainable transitions by experimenting at academic conferences2015In: Journal of Cleaner Production, ISSN 0959-6526, E-ISSN 1879-1786, Vol. 98, p. 1-7Article in journal (Refereed)
    Abstract [en]

    Major societal changes which challenge societal functions and actors activities are needed to enhance sustainable development. Thus sustainable transitions research emphasizes co-evolutionary approaches involving a multitude of actors including the business sector, the government, and academia. Academic research can catalyse sustainable transitions by critically analyse current societal trends to develop and disseminate new knowledge. At research conferences, researchers and practitioners meet to network and discuss recent research findings providing arenas for testing and evaluating ideas to enhance sustainable transitions. This however requires some modifications of the standard design of a research conference. Here we report learning outcomes from experimenting at the 18th international Greening of Industry Network conference during 21-24 October 2012 in Linkoping, Sweden. The conference was a combination of a traditional conference structure with different interactive elements such as sustainability jam-sessions to discuss future challenges of six companies and clusters of companies at their site. The intention of doing so was to enhance learning outcomes both for visiting conference delegates and among actors in the host region. This was perceived by the participants as an innovative approach fostering both problem solving and creation of new ideas. Four out of the six companies continued dialogues about sustainable production fields or bio-refineries with Linkoping University. In addition we introduce and summarize research findings presented at the conference which were further developed into research articles. The essence of these articles covers sustainable industry management; cleaner production; industrial ecology; cooperation between industry, governments and academics; dissemination of concepts and technologies; methods and tools for modelling and measuring of industrial symbiosis, CO2 performance and eco-efficiency.

  • 348.
    Baas, Leenard
    et al.
    Linköping University, Department of Management and Engineering, Environmental Technology and Management. Linköping University, Faculty of Science & Engineering.
    Mirata, Murat
    Linköping University, Department of Management and Engineering, Environmental Technology and Management. Linköping University, Faculty of Science & Engineering.
    Bio-resource production on the basis of Industrial Ecology in four European harbours, harbour cities and their region2015In: Économie Circulaire et Écosystémes Portuaires (Circular Economy and Port Ecosystems) / [ed] Yann Alix, Nicolas Mat, Juliette Cerceau, Paris: Foundation Sefacil , 2015, 1, p. 223-242Chapter in book (Refereed)
    Abstract [en]

    This chapter re ects the design and starting performance of the Symbiotic bio- Energy Port Integration with Cities by 2020 project (EPIC 2020). The EPIC 2020 project is coordinated by the city of Malmö and is performed in four harbour cities: Malmö in Sweden, Mantova in Italy, Navipe-Akarport in Greece, and Wismar (including Rostock) in Germany. A number of expert organisations and energy companies also take part in the project.

    The overall objectives of EPIC 2020 are to build operational and strategic capacity and know-how to promote ef cient use of available bioenergy resources, ef cient conversion technologies and interactions between different biomass supply chains. EPIC 2020 targets the untapped bioenergy resource potential of ports and port regions and the challenge of generating urban economic growth based on bioenergy resources. The project applies the industrial symbiosis approach to achieve its overall objectives.

    Ports provide crossing points between transport modes of goods and resources, with connections to hinterland and on-site industrial activities and a nearby urban setting. This means that ports, despite their limited areal footprint, have access to signi cant quantities of bio wastes, surrounding bioenergy resources, biomass from crossing supply chains and energy from intensive activities. The aim is to create platforms for the transformation of port areas to ef cient and carbon-neutral urban-integrated energy systems, where residual bio and energy resources and linear biomass supply chains are utilized as local and network resources.

    The EPIC 2020 project is halfway the 3-year performance framework. Re ection to primary results is provided. 

  • 349.
    Babu Moparthi, Satish
    et al.
    Aix Marseille University, France.
    Carlsson, Uno
    Linköping University, Department of Physics, Chemistry and Biology, Chemistry. Linköping University, Faculty of Science & Engineering.
    Vincentelli, Renaud
    University of Aix Marseille, France.
    Jonsson, Bengt-Harald
    Linköping University, Department of Physics, Chemistry and Biology, Chemistry. Linköping University, Faculty of Science & Engineering.
    Hammarström, Per
    Linköping University, Department of Physics, Chemistry and Biology, Chemistry. Linköping University, Faculty of Science & Engineering.
    Wenger, Jerome
    Aix Marseille University, France.
    Differential conformational modulations of MreB folding upon interactions with GroEL/ES and TRiC chaperonin components2016In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 6, no 28386Article in journal (Refereed)
    Abstract [en]

    Here, we study and compare the mechanisms of action of the GroEL/GroES and the TRiC chaperonin systems on MreB client protein variants extracted from E. coli. MreB is a homologue to actin in prokaryotes. Single-molecule fluorescence correlation spectroscopy (FCS) and time-resolved fluorescence polarization anisotropy report the binding interaction of folding MreB with GroEL, GroES and TRiC. Fluorescence resonance energy transfer (FRET) measurements on MreB variants quantified molecular distance changes occurring during conformational rearrangements within folding MreB bound to chaperonins. We observed that the MreB structure is rearranged by a binding-induced expansion mechanism in TRiC, GroEL and GroES. These results are quantitatively comparable to the structural rearrangements found during the interaction of beta-actin with GroEL and TRiC, indicating that the mechanism of chaperonins is conserved during evolution. The chaperonin-bound MreB is also significantly compacted after addition of AMP-PNP for both the GroEL/ES and TRiC systems. Most importantly, our results showed that GroES may act as an unfoldase by inducing a dramatic initial expansion of MreB (even more than for GroEL) implicating a role for MreB folding, allowing us to suggest a delivery mechanism for GroES to GroEL in prokaryotes.

  • 350.
    Babu Moparthi, Satish
    et al.
    Linköping University, Department of Physics, Chemistry and Biology, Chemistry. Linköping University, Faculty of Science & Engineering. Institut Fresnel, CNRS UMR 7249, Aix-Marseille Université, Marseille, France.
    Sjölander, Daniel
    Linköping University, Department of Physics, Chemistry and Biology, Chemistry. Linköping University, The Institute of Technology.
    Villebeck, Laila
    Linköping University, Department of Physics, Chemistry and Biology, Molecular Biotechnology. Linköping University, The Institute of Technology.
    Jonsson, Bengt-Harald
    Linköping University, Department of Physics, Chemistry and Biology, Chemistry. Linköping University, The Institute of Technology.
    Hammarström, Per
    Linköping University, Department of Physics, Chemistry and Biology, Chemistry. Linköping University, The Institute of Technology.
    Carlsson, Uno
    Linköping University, Department of Physics, Chemistry and Biology, Chemistry. Linköping University, The Institute of Technology.
    Transient conformational remodeling of folding proteins by GroES - Individually and in concert with GroEL2014In: Journal of chemical biology, ISSN 1864-6158, E-ISSN 1864-6166, Vol. 7, no 1, p. 1-15Article, review/survey (Refereed)
    Abstract [en]

    The commonly accepted dogma of the bacterial GroE chaperonin system entails protein folding mediated by cycles of several ATP-dependent sequential steps where GroEL interacts with the folding client protein. In contrast, we herein report GroES-mediated dynamic remodeling (expansion and compression) of two different protein substrates during folding: the endogenous substrate MreB and carbonic anhydrase (HCAII), a well-characterized protein folding model. GroES was also found to influence GroEL binding induced unfolding and compression of the client protein underlining the synergistic activity of both chaperonins, even in the absence of ATP. This previously unidentified activity by GroES should have important implications for understanding the chaperonin mechanism and cellular stress response. Our findings necessitate a revision of the GroEL/ES mechanism.

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