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  • 1.
    Arnoldsson, Göran
    Umeå University, Faculty of Social Sciences, Statistics.
    Generalised Linear Models and Optimal Design1994Licentiate thesis, monograph (Other academic)
  • 2.
    Arnoldsson, Göran
    Umeå University, Faculty of Social Sciences, Statistics.
    Optimal Design for Inference in Generalized Linear Models1997Doctoral thesis, monograph (Other academic)
  • 3.
    Arnoldsson, Göran
    Umeå University, Faculty of Social Sciences, Statistics.
    Optimal designs for beta-binomial logistic regression models2003In: Journal of Applied Statistics, Vol. 30, no 8, p. 939-951Article in journal (Refereed)
  • 4.
    Arnoldsson, Göran
    Umeå University, Faculty of Social Sciences, Statistics.
    Visualisering av kvantitativ information: Grafik och regression2007In: Qvartilen, ISSN 0283-3654, Vol. 22, no 4Article in journal (Other academic)
  • 5.
    Berhe, Leakemariam
    et al.
    Wondo Genet College of Forestry and Natural Resources, Hawassa University, Awassa, Ethiopia.
    Arnoldsson, Göran
    Umeå University, Faculty of Social Sciences, Department of Statistics.
    Ds-optimal designs for Kozak's tree taper model2011In: Journal of Applied Statistics, ISSN 0266-4763, E-ISSN 1360-0532, Vol. 38, no 5, p. 1087-1102Article in journal (Refereed)
    Abstract [en]

    In this work, we study Ds-optimal design for Kozak's tree taper model. The approximate Ds-optimal designs are found invariant to tree size and hence create a ground to construct a general replication-free Ds-optimal design. Even though the designs are found not to be dependent on the parameter value p of the Kozak's model, they are sensitive to the stimes1 subset parameter vector values of the model. The 12 points replication-free design (with 91% efficiency) suggested in this study is believed to reduce cost and time for data collection and more importantly to precisely estimate the subset parameters of interest.

  • 6.
    Berhe, Leakemariam
    et al.
    Umeå University, Faculty of Social Sciences, Statistics.
    Arnoldsson, Göran
    Umeå University, Faculty of Social Sciences, Statistics.
    Tree taper models for Cupressus lusitanica plantations in Ethiopia2008In: Southern Forests: a Journal of Forest Science, Vol. 70, no 3, p. 193-203Article in journal (Refereed)
  • 7. Sellstrom, J
    et al.
    Guldbrandsson, E
    Bremberg, K
    Hjern, S
    Arnoldsson, Göran
    Umeå University, Faculty of Social Sciences, Statistics.
    Association between childhood community safety interventions and hospital injury records: A multilevel study2003In: Journal of Epidemiology and Community Health, Vol. 57, p. 724-729Article in journal (Refereed)
  • 8.
    Sellström, E.
    et al.
    Department of Health Sciences, Mid Sweden University, Östersund, Sweden.
    O’Campo, P.
    Centre for Research on Inner City Health,The Li Ka Shing Knowledge Institute of St.Michael’s Hospital, Toronto, Canada.
    Muntaner, C.
    Faculty of Nursing, Department of Psychiatry and Public Health Sciences, University of Toronto,Toronto,Canada.
    Arnoldsson, Göran
    Umeå University, Faculty of Social Sciences, Department of Statistics.
    Hjern, A.
    Department of Women’s and Children’s Health, Uppsala university, Uppsala, Sweden .
    Hospital admissions of young persons for illicit drug use or abuse: does neighborhood of residence matter?2011In: Health and Place, ISSN 1353-8292, E-ISSN 1873-2054, Vol. 17, no 2, p. 551-557Article in journal (Refereed)
    Abstract [en]

    Adolescence constitutes a period of risk for drug use and drug use disorders. Previous research, largely focused on individual risk factors, has failed to include neighborhood structure in the study of determinants of youth drug use or abuse. A cohort of 76,693 adolescents ages 13–15 from 586 urban neighborhoods in Sweden were followed up for 12 years, from age 16 to age 28. Multilevel modeling was used to analyze neighborhood variations in hospital admissions due to illicit drug use or abuse. We found a variation of 8% by neighborhood economic status and the risk of being admitted to hospital increased 73% in low-compared to high-income neighborhoods. Our results suggest that neighborhood of residence in adolescence plays a significant role in predicting future health-related behaviors and that the need for drug abuse interventions at a neighborhood level is compelling.

  • 9.
    Sellström, Eva
    et al.
    Department of Health Sciences, MidSweden University, Östersund, Sweden.
    Arnoldsson, Göran
    Umeå University, Faculty of Social Sciences, Department of Statistics.
    Alricsson, Marie
    The Vårdal Institute, The Swedish Institute for Health Sciences, Lund University, Lund, Sweden.
    Hjern, Anders
    Centre for Epidemiology, Swedish National Board on Health and Welfare, Stockholm, Sweden.
    Obesity prevalence in a cohort of women in early pregnancy from a neighbourhood perspective2009In: BMC Pregnancy and Childbirth, ISSN 1471-2393, E-ISSN 1471-2393, Vol. 9, p. 37-Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: The evidence of an association between neighbourhood deprivation and overweight is established for different populations. However no previous studies on neighbourhood variations in obesity in pregnant women were found. In this study we aimed to determine whether obesity during early pregnancy varied by neighbourhood economic status. METHODS: A register based study on 94,323 primiparous pregnant women in 586 Swedish neighbourhoods during the years 1992-2001. Multilevel technique was used to regress obesity prevalence on socioeconomic individual-level variables and the neighbourhood economic status. Five hundred and eighty-six neighbourhoods in the three major cities of Sweden, Stockholm, Göteborg and Malmö, during 1992-2001, were included. The majority of neighbourhoods had a population of 4 00010 000 inhabitants. RESULTS: Seven per cent of the variation in obesity prevalence was at the neighbourhood level and the odds of being obese were almost doubled in poor areas. CONCLUSION: Our findings supports a community approach in the prevention of obesity in general and thus also in pregnant women.

  • 10.
    Sellström, Eva
    et al.
    Department of Health Sciences, MidSweden University.
    Arnoldsson, Göran
    Department of Health Sciences, MidSweden University.
    Bremberg, Sven
    Department of Health Sciences, MidSweden University.
    Hjern, Anders
    Department of Health Sciences, MidSweden University.
    The neighbourhood they live in: Does it matter to women's smoking habits during pregnancy?2008In: Health and Place, ISSN 1353-8292, E-ISSN 1873-2054, Vol. 14, no 2, p. 155-166Article in journal (Refereed)
    Abstract [en]

    Although the health risk of socioeconomic disadvantage over the life-course is fairly established, the mechanisms are less studied. One candidate pathway is long-term dysregulation of cortisol. This study assesses whether socioeconomic trajectories from adolescence to adulthood influences the regulation of cortisol in mid-adulthood, and further investigates the importance of adolescence as a critical period and of accumulation of socioeconomic disadvantage. Participants were drawn from a 27-year prospective cohort study (n = 732, 68% of the original cohort). Information on socioeconomic status (SES) was collected at the ages of 16 (based on parental occupation), 21, 30 and 43 (based on own occupation) years, and at 43 years participants collected one-day salivary cortisol samples at awakening, after 15 min, before lunch and at bedtime. We found that the cortisol awakening response (CAR) differed with respect to SES trajectory; those with stable low or early low/upwardly mobile SES tended to display higher CAR than those with early high/downwardly mobile, highly mobile or stable high trajectories. Further analyses revealed that early low SES was related to higher CAR, and in women low SES was related to lower bedtimecortisol, independently of later SES and potential confounders. We found no support for a linear effect of accumulation of socioeconomic disadvantage. In conclusion, our study gives support for an independent effect of low socioeconomic status early in life, on the regulation of cortisol in adulthood.

  • 11.
    Werner, Mimmi
    et al.
    Umeå University, Faculty of Medicine, Department of Clinical Sciences, Otorhinolaryngology.
    Van De Water, Thomas R.
    Andersson, Therese
    Umeå University, Faculty of Medicine, Department of Clinical Sciences, Otorhinolaryngology.
    Arnoldsson, Göran
    Umeå University, Faculty of Social Sciences, Umeå School of Business and Economics (USBE), Statistics.
    Berggren, Diana
    Umeå University, Faculty of Medicine, Department of Clinical Sciences, Otorhinolaryngology.
    Morphological and morphometric characteristics of vestibular hair cells and support cells in long term cultures of rat utricle explants2012In: Hearing Research, ISSN 0378-5955, E-ISSN 1878-5891, Vol. 283, no 1-2, p. 107-116Article in journal (Refereed)
    Abstract [en]

    A method for long term culture of utricular macula explants is demonstrated to be stable and reproducible over a period of 28 days in vitro (DIV). This culture system for four-day-old rat utricular maculae is potentially suitable for studies of hair cell loss, repair and regeneration processes as they occur in post-natal mammalian inner ear sensory epithelia. The cellular events that occur within utricular macula hair cell epithelia during 28 days of culture are documented from serial sections. Vestibular hair cells (HCs) and supporting cells (SCs) were systematically counted using light microscopy (LM) and the assistance of morphometric computer software. Ultrastructural observations were made with transmission electron microscopy (TEM) for describing the changes in the fine detailed morphological characteristics that occurred in the explants related to time in vitro. After 2 DIV the density of HCs was 77%, at 21 DIV it was 69%, and at 28 DIV it was 52% of HCs present at explantation. Between 2 DIV and 28 DIV there was a 1.7% decrease of the vestibular macula HC density per DIV. The corresponding decrease of SC density within the utricular explants was less than 1% per DIV. The overall morphology of the epithelia, i.e. relationship of HCs to SCs, was well preserved during the first two weeks in culture. After this time a slight deterioration of the epithelia was observed and although type I and type II HCs were identified by TEM observations, these two HC types could no longer be distinguished from one another by LM observations. In preparations cultured for 21 DIV, SC nuclei were located more apical and further away from the basal membrane compared to their position in macula explants fixed immediately after dissection. The loss of cells that occurred was probably due to expulsion from the apical (i.e. luminal) surface of the sensory epithelia, but no lesions of the apical lining or ruptures of the basal membrane were observed. There were no significant changes in the volume of the vestibular HC comprising macular epithelium during the observation period of 28 DIV.

  • 12.
    Werner, Mimmi
    et al.
    Umeå University, Faculty of Medicine, Department of Clinical Sciences, Otorhinolaryngology.
    Van De Water, Thomas R.
    Hammarsten, Peter
    Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
    Arnoldsson, Göran
    Umeå University, Faculty of Social Sciences, Umeå School of Business and Economics (USBE), Statistics.
    Berggren, Diana
    Umeå University, Faculty of Medicine, Department of Clinical Sciences, Otorhinolaryngology.
    Morphological and morphometric characterization of direct transdifferentiation of support cells into hair cells in ototoxin-exposed neonatal utricular explants2015In: Hearing Research, ISSN 0378-5955, E-ISSN 1878-5891, Vol. 321, p. 1-11Article in journal (Refereed)
    Abstract [en]

    We have studied aminoglycoside-induced vestibular hair-cell renewal using long-term culture of utricular macula explants from 4-day-old rats. Explanted utricles were exposed to 1 mM of gentamicin for 48 h, during 2nd and 3rd days in vitro (DIV), and then recovering in unsupplemented medium. Utricles were harvested at specified time points from the 2nd through the 28th DIV. The cellular events that occurred within hair cell epithelia during the culture period were documented from serial sectioned specimens. Vestibular hair cells (HCs) and supporting cells (SCs) were systematically counted using light microscopy (LM) with the assistance of morphometric software. Ultrastructural observations were made from selected specimens with transmission electron microscopy (TEM). After 7 DIV, i.e. four days after gentamicin exposure, the density of HCs was 11% of the number of HCs observed in non-gentamicin-exposed control explants. At 28 DIV the HC density was 61% of the number of HCs observed in the control group explant specimens. Simultaneously with this increase in HCs there was a corresponding decline in the number of SCs within the epithelium. The proportion of HCs in relation to SCs increased significantly in the gentamicin-exposed explant group during the 5th to the 28th DIV period of culture. There were no significant differences in the volume estimations of the gentamicin-exposed and the control group explants during the observed period of culture. Morphological observations showed that gentamicin exposure induced extensive loss of HCs within the epithelial layer, which retained their intact apical and basal linings. At 7 to 14 DIV (i.e. 3-11 days after gentamicin exposure) a pseudostratified epithelium with multiple layers of disorganized cells was observed. At 21 DIV new HCs were observed that also possessed features resembling SCs. After 28 DIV a new luminal layer of HCs with several layers of SCs located more basally characterized the gentamicin-exposed epithelium. No mitoses were observed within the epithelial layer of any explants. Our conclusion is that direct transdifferentiation of SCs into HCs was the only process contributing to the renewal of HCs after gentamicin exposure in these explants of vestibular inner ear epithelia obtained from the labyrinths of 4-day-old rats.

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