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  • 1. Ballo, Ahmed M.
    et al.
    Xia, Wei
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Palmquist, Anders
    Lindahl, Carl
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Emanuelsson, Lena
    Lausmaa, Jukka
    Engqvist, Håkan
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Thomsen, Peter
    Bone tissue reactions to biomimetic ion-substituted apatite surfaces on titanium implants2012In: Journal of the Royal Society Interface, ISSN 1742-5689, E-ISSN 1742-5662, Vol. 9, no 72, p. 1615-1624Article in journal (Refereed)
    Abstract [en]

    The aim of this study was to evaluate the bone tissue response to strontium-and silicon-substituted apatite (Sr-HA and Si-HA) modified titanium (Ti) implants. Sr-HA, Si-HA and HA were grown on thermally oxidized Ti implants by a biomimetic process. Oxidized implants were used as controls. Surface properties, i.e. chemical composition, surface thickness, morphology/pore characteristics, crystal structure and roughness, were characterized with various analytical techniques. The implants were inserted in rat tibiae and block biopsies were prepared for histology, histomorphometry and scanning electron microscopy analysis. Histologically, new bone formed on all implant surfaces. The bone was deposited directly onto the Sr-HA and Si-HA implants without any intervening soft tissue. The statistical analysis showed significant higher amount of bone-implant contact (BIC) for the Si-doped HA modification (P = 0.030), whereas significant higher bone area (BA) for the Sr-doped HA modification (P = 0.034), when compared with the non-doped HA modification. The differences were most pronounced at the early time point. The healing time had a significant impact for both BA and BIC (P < 0.001). The present results show that biomimetically prepared Si-HA and Sr-HA on Ti implants provided bioactivity and promoted early bone formation.

  • 2.
    Ballo, Ahmed
    et al.
    Gothenburg University.
    Xia, Wei
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Lindahl, Carl
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Emanuelsson, Lena
    Gothenburg University.
    Palmqvist, Anders
    Gothenburg University.
    Lausmaa, Jukka
    SP.
    Engqvist, Håkan
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Thomsen, Peter
    Gothenburg University.
    Early bone tissue responses to a slicon-substituted apatite/titanium dioxide coating on titanium implant2010Conference paper (Refereed)
  • 3.
    Ballo, Ahmed
    et al.
    Gothenburg University.
    Xia, Wei
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Lindahl, Carl
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Lausmaa, Jukka
    SP.
    Engqvist, Håkan
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Thomsen, Peter
    Gothenburg University.
    Bone responses to ions-substituted apatite/titanium dioxide coating on titanium implants2010Conference paper (Refereed)
  • 4.
    Lilja, Mirjam
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials.
    Lindahl, Carl
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Xia, Wei
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Engqvist, Håkan
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Strømme, Maria
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials.
    The effect of Si-doping on the release of antibiotic from hydroxyapatite coatings2013In: Journal of Biomaterials and Nanobiotechnology, ISSN 2158-7027, E-ISSN 2158-7043, Vol. 4, no 3, p. 237-241Article in journal (Refereed)
    Abstract [en]

    Herein, we show that incorporation of ions during biomimetic coating deposition may be utilized to tailor the drug loading capacity of hydroxyapatite (HA) coatings. Pure biomimetic HA (HA-B) and Si-doped equivalents (SiHA-B) where deposited by a biomimetic process onto titanium dioxide covered titanium substrates. The antibiotic Cephalothin was incorporated into the coatings by adsorptive loading and the release was studied in-vitro. SiHA-B coatings exhibited superior drug incorporation capacity compared to pure HA-B coatings, resulting in a drug release profile dominated by an initial 10 min burst effect while a more prolonged 10 hour release was observed from HA-B coatings. The results emphasize the possibility to impact the drug release kinetics from implant coatings by selective doping elements and the use of thin, biomimetic HA-coatings as drug delivery vehicles. Functionalizing metal implants with SiHA-B coatings presents an interesting strategy towards creating synergetic effects through ion- and antibiotic release and, hence, contributing both towards preventing post-surgical infections while at the same time enhancing the bone-bonding ability.

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  • 5.
    Lindahl, Carl
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Biomimetic Deposition of Hydroxyapatite on Titanium Implant Materials2012Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The clinical success of a bone-anchored implant is controlled by many factors such as implant shape, chemical composition, mechanical and surface properties. The surface properties (e.g. charge, wettability and roughness) are considered to be important parameters for the biological acceptance of the biomaterial, whereas the bulk properties control the biomechanical behaviour. For implants designed to be used in load-bearing applications in the skeletal system, the biomaterial should preferably integrate into bone tissue for a long lasting function. Lack of integration between the implant and bone increases the risk of micromotions, infections, soft tissue encapsulation, which all reduces the survival rate of the implant and makes revision surgery necessary. Coatings and surface modifications can be used to tailor properties of implant surfaces, and further improve the potential bone bonding and bone in-growth, compared to unmodified surfaces. A biomimetic method, developed by Kokubo, can be used to prepare a hydroxyapatite coating on to titanium substrates. The method is based on a solution based process where the compositions of the soaking medium and thus the formed coatings can be controlled. In this thesis, titanium (oxide) surfaces have been tailored via deposition of ion substituted hydroxyapatite coatings. Biologically relevant ions like strontium, silicon and fluoride were incorporated into apatite coatings. The substrates included well-defined rutile single crystals, as well as poly-crystalline titanium oxide surfaces and experimental Ti implants. The results showed that incorporation of substitute ions alters the morphology, crystallinity, composition and dissolution rates of apatite coatings. The in vivo effects of the ion substituted apatite coatings were also studied. The results showed that the ion substituted apatite coatings have good biocompatibility and can promote early bone formation.

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  • 6.
    Lindahl, Carl
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Borchardt, Per
    Department of Chemistry and Materials Technology, SP Technical Research Institute of Sweden.
    Lausmaa, Jukka
    Department of Chemistry and Materials Technology, SP Technical Research Institute of Sweden.
    Xia, Wei
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Engqvist, Håkan
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Studies of early growth mechanisms of hydroxyapatite on single crystalline rutile: a model system for bioactive surfaces2010In: Journal of materials science. Materials in medicine, ISSN 0957-4530, E-ISSN 1573-4838, Vol. 21, no 10, p. 2743-2749Article in journal (Refereed)
    Abstract [en]

    Previous studies have shown that crystalline titanium oxide is in vitro bioactive and that there are differences in the HA formation mechanism depending on the crystalline direction of the titanium oxide surface. In the present study, the early adsorption of calcium and phosphate ions on three different surface directions of the single-crystal rutile TiO2 substrate has been investigated. A crucial step in the nucleation of HA is believed to be the adsorption of Ca2+ and PO4 3− from phosphate buffer solutions. The (001), (100) and (110) single crystalline rutile surfaces were soaked in phosphate buffer saline solution for 10 min, 1 h and 24 h at 37°C. The surfaces were then analyzed using time-of-flight secondary ion mass spectrometry (TOF-SIMS) and X-ray photoelectron spectroscopy (XPS). The results show that the adsorption of Ca2+ and PO4 3− is faster on the (001) and (100) surfaces than on the (110) surface. This study also shows that TOF-SIMS can be used as a tool to better understand the adsorption of calcium and phosphate ions and the growth mechanism of HA. This knowledge could be used to tailor new bioactive surfaces for better biological reaction.

  • 7.
    Lindahl, Carl
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Engqvist, Håkan
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Xia, Wei
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Effect of strontium ions on the early formation of biomimetic apatite on single crystalline rutile2013In: Applied Surface Science, ISSN 0169-4332, E-ISSN 1873-5584, Vol. 266, p. 199-204Article in journal (Refereed)
    Abstract [en]

    Single crystalline rutile is a good model to investigate the growth mechanism of hydroxyapatite on bioactive Ti surfaces. Previous studies have shown the difference on different crystalline rutile faces in the early stage and during the growth of HAp crystals from simulated body fluids. It is known that the biological apatite crystal is an ion-substituted apatite. Ion substitution will influence the HAp crystal growth and morphology. In the present study, the effect of strontium ions on the adsorption of Ca and phosphate ions on three different faces of single crystalline rutile substrates has been investigated. The ion adsorption is the crucial step in the nucleation of HAp crystals on specific surfaces. Single crystalline rutile surfaces ((1 1 0), (1 0 0) and (0 0 1)) were soaked in phosphate buffer solutions containing calcium and strontium ions for different time periods. The results showed that the adsorption of Sr, Ca and P is faster on the (1 1 0) surface than on the (1 0 0) and (0 0 1) surfaces. Almost same amount of Sr ion was adsorbed on the surfaces compared to the adsorption of Ca ion. Strontium ion influenced the biological apatite formation in the early stage in this study.

  • 8.
    Lindahl, Carl
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Engqvist, Håkan
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Xia, Wei
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Influence of surface treatments on the bioactivity of Ti2013In: Biomaterials, ISSN 0142-9612, E-ISSN 1878-5905, Vol. 2013, p. 205601-Article in journal (Refereed)
    Abstract [en]

    Several techniques have been described to modify the surface of titanium to make it more bioactive. Heat treatment (HT) and sodium hydroxide treatment (NaOH) have been used and can change the crystallinity and surface chemistry of titanium implants. However, no studies have systemically focused on comparing these different methods and their effect on the bioactivity of Ti. Therefore, in this study, Ti substrates were systematically treated using HT, NaOH, and a combination of HT and NaOH. The Ti plates were heat treated at various temperatures, and the plates were subjected to HT followed by soaking in NaOH or first soaked in NaOH and then heat treated. The morphology, crystallinity, hardness, water contact angle, and surface energy of the samples were analyzed as well as the bioactivity after immersion in PBS. Morphology and crystallinity changed with increasing temperature. The difference was most pronounced for the 800°C treated samples. The water contact angle decreased, and the surface energy increased with increasing temperature and was highest for 800°C. The rutile surface showed faster hydroxyapatite formation. NaOH treatment of the HT Ti samples increased the surface energy and improved its bioactivity further. Also, HT of NaOH samples improved the bioactivity compared to only HT.

  • 9.
    Lindahl, Carl
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Pujari-Palmer, Shiuli
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Hoess, Andreas
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Ott, Marjam
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Engqvist, Håkan
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Xia, Wei
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    The influence of Sr content in calcium phosphate coatings2015In: Materials science & engineering. C, biomimetic materials, sensors and systems, ISSN 0928-4931, E-ISSN 1873-0191, Vol. 53, p. 322-330Article in journal (Refereed)
    Abstract [en]

    In this study calcium phosphate coatings with different amounts of strontium.(Sr) were prepared using a biomineralization method. The incorporation of Sr changed the composition and morphology of coatings from plate-like to sphere-like morphology. Dissolution testing indicated that the solubility of the coatings increased with increased Sr concentration. Evaluation of extracts (with Sr concentrations ranging from 0 to 237 mu g/mL) from the HA, 0.06Sr, 0.6Sr, and 12Sr coatings during in vitro cell cultures showed that Sr incorporation into coatings significantly enhanced the ALP activity in comparison to cells treated with control and HA eluted media. These findings show that calcium phosphate coatings could promote osteogenic differentiation even in a low amount of strontium. (C) 2015 Elsevier B.V. All rights reserved.

  • 10.
    Lindahl, Carl
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Xia, Wei
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Engqvist, Håkan
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Apatite coating co-doped with strontium and fluoride using a biomineralization method2012Conference paper (Refereed)
  • 11.
    Lindahl, Carl
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Xia, Wei
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Engqvist, Håkan
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Snis, Anders
    Arcam AB, Sweden.
    Lausmaa, Jukka
    Palmquist, Anders
    Department of Biomaterials, Sahlgrenska Academy at the University of Gothenburg, Gothenburg.
    Biomimetic calcium phosphate coating of additively manufactured porous CoCr implants2015In: Applied Surface Science, ISSN 0169-4332, E-ISSN 1873-5584, Vol. 353, p. 40-47Article in journal (Refereed)
    Abstract [en]

    The aim of this work was to study the feasibility to use a biomimetic method to prepare biomimetic hydroxyapatite (HA) coatings on CoCr substrates with short soaking times and to characterize the properties of such coatings. A second objective was to investigate if the coatings could be applied to porous CoCr implants manufactured by electron beam melting (EBM). The coating was prepared by immersing the pretreated CoCr substrates and EBM implants into the phosphate-buffered solution with Ca2+ in sealed plastic bottles, kept at 60 degrees C for 3 days. The formed coating was partially crystalline, slightly calcium deficient and composed of plate-like crystallites forming roundish flowers in the size range of 300-500 nm. Cross-section imaging showed a thickness of 300-500 nm. In addition, dissolution tests in Tris-HCl up to 28 days showed that a substantial amount of the coating had dissolved, however, undergoing only minor morphological changes. A uniform coating was formed within the porous network of the additive manufactured implants having similar thickness and morphology as for the flat samples. In conclusion, the present coating procedure allows coatings to be formed on CoCr and could be used for complex shaped, porous implants made by additive manufacturing.

  • 12.
    Lindahl, Carl
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Xia, Wei
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Lausmaa, Jukka
    BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Göteborg och Dept of Chemistry and Materials Technology, SP Technical Research Institute of Sweden, Borås.
    Borchardt, Per
    BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Göteborg och Dept of Chemistry and Materials Technology, SP Technical Research Institute of Sweden, Borås.
    Engqvist, Håkan
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Strontium and silicon co-doped apatite coating:: Preparation and as vehicles for ion delivery2012In: Journal of Biomaterials and Nanobiotechnology, ISSN 2158-7027, Vol. 3, no 3, p. 335-341Article in journal (Refereed)
  • 13.
    Lindahl, Carl
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Xia, Wei
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Lausmaa, Jukka
    Department of Chemistry and Materials Technology, SP Technical Research Institute of Sweden, Borås, Sweden .
    Borchardt, Per
    Department of Chemistry and Materials Technology, SP Technical Research Institute of Sweden, Borås, Sweden .
    Thomsen, Peter
    Institute for Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
    Engqvist, Håkan
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Co-substituted strontium and silicon apatite coatings for metallic implants2010In: Seventh SICOT/SIROT Annual International Conference, Gothenburg, Sweden, 2010., 2010Conference paper (Refereed)
  • 14.
    Lindahl, Carl
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Xia, Wei
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Lausmaa, Jukka
    Dept of Chemistry and Materials Technology, SP Technical Research Institute of Sweden, Borås.
    Engqvist, Håkan
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Incorporation of active ions into calcium phosphate coatings, their release behavior and mechanism2012In: Biomedical Materials, ISSN 1748-6041, E-ISSN 1748-605X, Vol. 7, no 4, p. 045018-Article in journal (Refereed)
    Abstract [en]

    The dissolution and release of active ions from ion-doped apatites is currently gaining interest due to indications of a beneficial biologic response. The release of ions from apatite coatings is important because it influences the biological effect of these types of materials. In this study the ion release from three different ion-doped apatite coatings (iHA coatings), SrCaP, SiHA and FHA, has been studied. The coatings were prepared by a mineralization method based on immersion in modified PBS solutions containing additions of Sr, Si or F. The kinetics of ion release from the iHA coatings were studied in two different media with and without calcium and phosphate ions (phosphate buffer saline solution (PBS) and Tris-HCl). The amount of cumulative release of Sr, Si and F ions from the iHA coatings was SrCaP > SiHA > FHA in Tris-HCl, which could be also be related to the solubility for these iHA coatings. According to analysis using the Korsmeyer-Peppas model, the release of ions from the coatings was in most cases controlled by a combination of Fickian diffusion and dissolution of the coatings. The morphologies of the iHA coatings were not markedly changed after immersion in Tris-HCl. In the phosphate buffer solution, there was a concurrent redeposition of new apatite crystals on the surface of all of the iHA coatings, which means there were both a dissolution and a remineralization process acting, ultimately controlling the ion release rate.

  • 15.
    Lindahl, Carl
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Xia, Wei
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Thomsen, Peter
    Institute for Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden .
    Lausmaa, Jukka
    Department of Chemistry and Materials Technology, SP Technical Research Institute of Sweden .
    Engqvist, Håkan
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Co-mineralization of fluoride substitued hydroxyapatite/TiO2 coating on Ti implants through a biomineralization process2009In: Scandinavian Society for Biomaterials (ScSB)  annual meeting 2009, Copenhagen, Denmark, 2009Conference paper (Refereed)
  • 16.
    Thorfve, Anna
    et al.
    University of Gothenburg.
    Lindahl, Carl
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Xia, Wei
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Igawa, Kazuyo
    University of Gothenburg.
    Emanuelsson, Lena
    Gothenburg University.
    Lindahl, Anders
    University of Gothenburg.
    Thomsen, Peter
    Gothenburg University.
    Engqvist, Håkan
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Palmqvist, Anders
    Gothenburg University.
    Tengvall, Pentti
    University of Gothenburg.
    Hydroxyapatite Coating with Li+ Affects the Wnt Signaling Pathway in vivo2013Conference paper (Refereed)
  • 17.
    Thorfve, Anna
    et al.
    University of Gothenburg.
    Lindahl, Carl
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Xia, Wei
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Igawa, Kazuyo
    Southern Tohoku General Hospital.
    Lindahl, Anders
    University of Gothenburg.
    Thomsen, Peter
    Gothenburg University.
    Palmqvist, Anders
    Gothenburg University.
    Tengvall, Pentti
    University of Gothenburg.
    Hydroxyapatite coating affects the Wnt signaling pathway during peri-implant healing in vivo2014In: Acta Biomaterialia, ISSN 1742-7061, E-ISSN 1878-7568, Vol. 10, no 3, p. 1451-1462Article in journal (Refereed)
    Abstract [en]

    Owing to its bio- and osteoconductivity, hydroxyapatite (HA) is a widely used implant material, but its osteogenic properties are only partly evaluated in vitro and in vivo. The present study focused on bone healing adjacent to HA-coated titanium (Ti) implants, with or without incorporated lithium ions (Li+). Special attention was given to the Wnt signaling pathway. The implants were inserted into rat tibia for 7 or 28 days and analyzed ex vivo, mainly by histomorphometry and quantitative real-time polymerase chain reaction (qPCR). HA-coated implants showed, irrespective of Li+ content, bone-implant contact (BIC) and removal torque values significantly higher than those of reference Ti. Further, the expression of OCN, CTSK, COL1A1, LRP5/6 and WISP1 was significantly higher in implant-adherent cells of HA-coated implants, with or without Li+. Significantly higher beta-catenin expression and significantly lower COL2A1 expression were observed in pen-implant bone cells from HA with 14 ng cm(-2) released Li+. Interestingly, Ti implants showed a significantly larger bone area (BA) in the threads than HA with 39 ng cm(-2) released Li+, but had a lower BIC than any HA-coated implant. This study shows that HA, with or without Li+, is a strong activator of the Wnt signaling pathway, and may to some degree explain its high bone induction capacity.

  • 18.
    Xia, Wei
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Ballo, Ahmed
    Gothenburg University.
    Lindahl, Carl
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Thomsen, Peter
    Gothenburg University.
    Lausmaa, Jukka
    SP.
    Engqvist, Håkan
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Biomimetic ion substituted hydroxyapatite coatings on titanium for orthopedic implants2010In: Seventh SICOT/SIROT Annual International Conference, 2010Conference paper (Refereed)
  • 19.
    Xia, Wei
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Lindahl, Carl
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Ballo, Ahmed
    Gothenburg University.
    Hoess, Andreas
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Pujari, Shiuli
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Lausmaa, Jukka
    SP.
    Thomsen, Peter
    Gothenburg University.
    Ott, Marjam
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Engqvist, Håkan
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Biological properties of ion substituted apatite coatings2013Conference paper (Refereed)
  • 20.
    Xia, Wei
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Lindahl, Carl
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Engqvist, Håkan
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Lausmaa, Jukka
    Department of Chemistry and Materials Technology, SP Technical Research Institute of Sweden .
    Thomsen, Peter
    Institute for Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden .
    Ion substituted hydroxyapatite coatings2009Patent (Other (popular science, discussion, etc.))
  • 21.
    Xia, Wei
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Lindahl, Carl
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Lausmaa, Jukka
    Borchardt, Per
    Ballo, Ahmed
    Thomsen, Peter
    Engqvist, Håkan
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Biomineralized strontium-substituted apatite/titanium dioxide coating on titanium surfaces2010In: Acta Biomaterialia, ISSN 1742-7061, Vol. 6, no 4, p. 1591-1600Article in journal (Refereed)
    Abstract [en]

    Bone mineral is a multi-substituted calcium phosphate. One of these ion substitutions, strontium, has been proven to increase bone strength and decrease bone resorption. Biomimetics is a potential way to prepare surfaces that provide a favorable bone tissue response, thus enhancing the fixation between bone and implants. Here we prepared double-layered strontium-substituted apatite and titanium dioxide coatings on titanium substrates via mimicking bone mineralization. Morphology, crystallinity, surface chemistry and composition of Sr-substituted coatings formed via biomimetic coating deposition on crystalline titanium oxide substrates were studied as functions of soaking temperature and time in phosphate buffer solutions with different Sr ion concentration. The morphology of the biomimetic apatite changed from plate-like for the pure HA to sphere-like for the Sr ion substituted. Surface analysis results showed that 10-33% of Ca ions in the apatite have been substituted by Sr ions, and that the Sr ions were chemically bonded with apatite and successfully incorporated into the structure of apatite.

  • 22.
    Xia, Wei
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Lindahl, Carl
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Lausmaa, Jukka
    Engqvist, Håkan
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Biomimetic Hydroxyapatite Deposition on Titanium Oxide Surfaces for Biomedical Application2011In: Advances in Biomimetics, INTECH , 2011Chapter in book (Refereed)
  • 23.
    Xia, Wei
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Lindahl, Carl
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Lausmaa, Jukka
    SP.
    Thomsen, Peter
    Gothenburg University.
    Engqvist, Håkan
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Biomimetic fluoride hydroxyapatite coating on dental implants2010In: Scandinavian Society for Biomaterials (ScSB)  annual meeting 2010 – Interfacing biology and materials, 2010Conference paper (Refereed)
  • 24.
    Xia, Wei
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Lindahl, Carl
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Palmqvist, Anders
    Gothenburg University.
    Engqvist, Håkan
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Apatite Coatings: Ion Substitution and Biological Properties2013In: Advanced in Bioceramics and Porous CeramicsArticle in journal (Refereed)
  • 25.
    Xia, Wei
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Lindahl, Carl
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Persson, Cecilia
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Thomsen, Peter
    Lausmaa, Jukka
    Engqvist, Håkan
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Changes of Surface Composition and Morphology after Incorporation of Ions into Biomimetic Apatite Coating2010In: Journal of Biomaterials and Nanobiotechnology, ISSN 2158-7027, E-ISSN 2158-7043, Vol. 1, no 1, p. 7-16Article in journal (Refereed)
  • 26.
    Xia, Wei
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Lindahl, Carl
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Thomsen, Peter
    Institute for Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden .
    Borchardt, Per
    Department of Chemistry and Materials Technology, SP Technical Research Institute of Sweden .
    Lausmaa, Jukka
    Department of Chemistry and Materials Technology, SP Technical Research Institute of Sweden .
    Engqvist, Håkan
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Co-mineralization of strontium substituted hydroxyapatite on polycrystalline rutile surface through a biomineralization process2009Conference paper (Refereed)
  • 27.
    Xia, Wei
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Lindahl, Carl
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Thomsen, Peter
    Institute for Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden .
    Borchardt, Per
    Department of Chemistry and Materials Technology, SP Technical Research Institute of Sweden .
    Lausmaa, Jukka
    Department of Chemistry and Materials Technology, SP Technical Research Institute of Sweden .
    Sjövall, Peter
    Department of Chemistry and Materials Technology, SP Technical Research Institute of Sweden .
    Engqvist, Håkan
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Biomimetic ion substituted apatite coating on titanium implants: surface composition and morphology control2009Conference paper (Refereed)
1 - 27 of 27
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