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  • 1. Adams, Charleen
    et al.
    Richmond, Rebecca C
    Santos Ferreira, Diana L
    Spiller, Wes
    Tan, Vanessa Y
    Zheng, Jie
    Wurtz, Peter
    Donovan, Jenny L
    Hamdy, Freddie C
    Neal, David E
    Lane, J Athene
    Davey Smith, George
    Relton, Caroline L
    Eeles, Rosalind A
    Henderson, Brian E
    Haiman, Christopher A
    Kote-Jarai, Zsofia
    Schumacher, Fredrick R
    Amin Al Olama, Ali
    Benlloch, Sara
    Muir, Kenneth
    Berndt, Sonja I
    Conti, David V
    Wiklund, Fredrik
    Chanock, Stephen J
    Gapstur, Susan M
    Stevens, Victoria L
    Tangen, Catherine M
    Batra, Jyotsna
    Clements, Judith A
    Grönberg, Henrik
    Pashayan, Nora
    Schleutker, Johanna
    Albanes, Demetrius
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    West, Catharine M L
    Mucci, Lorelei A
    Cancel-Tassin, Geraldine
    Koutros, Stella
    Sørensen, Karina D
    Maehle, Lovise
    Travis, Ruth C
    Hamilton, Robert
    Ingles, Sue Ann
    Rosenstein, Barry S
    Lu, Yong-Jie
    Giles, Graham G
    Kibel, Adam S
    Vega, Ana
    Kogevinas, Manolis
    Penney, Kathryn L
    Park, Jong Y
    Stanford, Janet L
    Cybulski, Cezary
    Nordestgaard, Borge G
    Brenner, Hermann
    Maier, Christiane
    Kim, Jeri
    John, Esther M
    Teixeira, Manuel R
    Neuhausen, Susan L
    DeRuyck, Kim
    Razack, Azad
    Newcomb, Lisa F
    Lessel, Davor
    Kaneva, Radka P
    Usmani, Nawaid
    Claessens, Frank
    Townsend, Paul
    Gago Dominguez, Manuela
    Roobol, Monique J
    Menegaux, Florence
    Khaw, Kay-Tee
    Cannon-Albright, Lisa A
    Pandha, Hardev
    Thibodeau, Stephen N
    Martin, Richard M
    Circulating Metabolic Biomarkers of Screen-Detected Prostate Cancer in the ProtecT Study.2018In: Cancer Epidemiology, Biomarkers and Prevention, ISSN 1055-9965, E-ISSN 1538-7755, article id cebp.0079.2018Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Whether associations between circulating metabolites and prostate cancer are causal is unknown. We report on the largest study of metabolites and prostate cancer (2,291 cases and 2,661 controls) and appraise causality for a subset of the prostate cancer-metabolite associations using two-sample Mendelian randomization (MR).

    MATERIALS AND METHODS: The case-control portion of the study was conducted in nine UK centres with men aged 50-69 years who underwent prostate-specific antigen (PSA) screening for prostate cancer within the Prostate testing for cancer and Treatment (ProtecT) trial. Two data sources were used to appraise causality: a genome-wide association study (GWAS) of metabolites in 24,925 participants and a GWAS of prostate cancer in 44,825 cases and 27,904 controls within the Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL) consortium.

    RESULTS: Thirty-five metabolites were strongly associated with prostate cancer (p <0.0014, multiple-testing threshold). These fell into four classes: i) lipids and lipoprotein subclass characteristics (total cholesterol and ratios, cholesterol esters and ratios, free cholesterol and ratios, phospholipids and ratios, and triglyceride ratios); ii) fatty acids and ratios; iii) amino acids; iv) and fluid balance. Fourteen top metabolites were proxied by genetic variables, but MR indicated these were not causal.

    CONCLUSIONS: We identified 35 circulating metabolites associated with prostate cancer presence, but found no evidence of causality for those 14 testable with MR. Thus, the 14 MR-tested metabolites are unlikely to be mechanistically important in prostate cancer risk.

    IMPACT: The metabolome provides a promising set of biomarkers that may aid prostate cancer classification.

  • 2. Bellavia, A
    et al.
    Larsson, S C
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Fish consumption and all-cause mortality in a cohort of Swedish men and women.2017In: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 281, no 1, p. 86-95Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Epidemiological studies of fish consumption and all-cause mortality have provided inconsistent results.

    OBJECTIVE: We examined the dose-response association between fish consumption and mortality from all causes in a large population-based cohort of Swedish men and women.

    METHODS: The study included 72 522 participants (33 973 women and 38 549 men), aged 45-83 years, from the Swedish Mammography Cohort and the Cohort of Swedish Men. Information on fish consumption was obtained through a self-administered questionnaire in 1997. Participants were followed for 17 years (1 January 1998 to 31 December 2014), and data on death and causes of death were ascertained through linkage to the Swedish Cause of Death Register. We used Cox proportional hazard regression to estimate hazard ratios (HRs) of death. Fish consumption was evaluated as a continuous predictor, flexibly modelled with restricted cubic splines to assess potential nonlinear associations.

    RESULTS: During follow-up, 16 730 deaths (7168 women and 9562 men) were recorded. The dose-response association between fish consumption and all-cause mortality was U-shaped. Compared with the median fish consumption (women: 25.0; men: 30.5 g day-1 ), lower levels of consumption were progressively associated with higher mortality risk up to 25% for women [HR 1.25; 95% confidence interval (CI): 1.11, 1.40] and 19% for men (HR 1.19; 95% CI: 1.07, 1.32) with no reported consumption. Increasingly higher levels of fish consumption were associated with higher mortality risk only amongst women, with a 39% higher mortality risk amongst women reporting the highest level of fish consumption (80 g day-1 ; HR 1.39; 95% CI: 1.15, 1.68).

    CONCLUSION: These results indicate a U-shaped association between fish consumption and all-cause mortality, particularly amongst women.

  • 3.
    Benetou, V.
    et al.
    Univ Athens, WHO Collaborating Ctr Nutr & Hlth, Unit Nutr Epidemiol & Nutr Publ Hlth, Dept Hyg Epidemiol & Med Stat,Sch Med, 75 Mikras Asias St, Athens 11527, Greece.
    Orfanos, P.
    Hellen Hlth Fdn, Athens, Greece;Univ Athens, WHO Collaborating Ctr Nutr & Hlth, Unit Nutr Epidemiol & Nutr Publ Hlth, Dept Hyg Epidemiol & Med Stat,Sch Med, 75 Mikras Asias St, Athens 11527, Greece.
    Feskanich, D.
    Harvard Med Sch, Boston, MA USA;Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.
    Michaëlsson, Karl
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Pettersson-Kymmer, U.
    Umea Univ, Dept Pharmacol & Clin Neurosci, Umea, Sweden;Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden.
    Byberg, Liisa
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Eriksson, S.
    Umea Univ, Dept Community Med, Umea, Sweden.
    Grodstein, F.
    Harvard Med Sch, Boston, MA USA;Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics. Karolinska Inst, Inst Environm Med, Div Nutr Epidemiol, Stockholm, Sweden.
    Jankovic, N.
    Wageningen Univ, Div Human Nutr, Wageningen, Netherlands;Univ Duisburg Essen, Inst Med Informat Biometry & Epidemiol, Ctr Clin Epidemiol, Fac Med, Essen, Germany.
    de Groot, L. C. P. G. M.
    Wageningen Univ, Div Human Nutr, Wageningen, Netherlands.
    Boffetta, P.
    Icahn Sch Med Mt Sinai, Inst Translat Epidemiol, New York, NY 10029 USA;Icahn Sch Med Mt Sinai, Tisch Canc Inst, New York, NY 10029 USA.
    Trichopoulou, A.
    Hellen Hlth Fdn, Athens, Greece.
    Mediterranean diet and hip fracture incidence among older adults: the CHANCES project2018In: Osteoporosis International, ISSN 0937-941X, E-ISSN 1433-2965, Vol. 29, no 7, p. 1591-1599Article in journal (Refereed)
    Abstract [en]

    The association between adherence to Mediterranean diet (MD) and hip fracture incidence is not yet established. In a diverse population of elderly, increased adherence to MD was associated with lower hip fracture incidence. Except preventing major chronic diseases, adhering to MD might have additional benefits in lowering hip fracture risk. Hip fractures constitute a major public health problem among older adults. Latest evidence links adherence to Mediterranean diet (MD) with reduced hip fracture risk, but still more research is needed to elucidate this relationship. The potential association of adherence to MD with hip fracture incidence was explored among older adults. A total of 140,775 adults (116,176 women, 24,599 men) 60 years and older, from five cohorts from Europe and the USA, were followed-up for 1,896,219 person-years experiencing 5454 hip fractures. Diet was assessed at baseline by validated, cohort-specific, food-frequency questionnaires, and hip fractures were ascertained through patient registers or telephone interviews/questionnaires. Adherence to MD was evaluated by a scoring system on a 10-point scale modified to be applied also to non-Mediterranean populations. In order to evaluate the association between MD and hip fracture incidence, cohort-specific hazard ratios (HR), adjusted for potential confounders, were estimated using Cox proportional-hazards regression and pooled estimates were subsequently derived implementing random-effects meta-analysis. A two-point increase in the score was associated with a significant 4% decrease in hip fracture risk (pooled adjusted HR 0.96; 95% confidence interval (95% CI) 0.92-0.99, p(heterogeneity) = 0.446). In categorical analyses, hip fracture risk was lower among men and women with moderate (HR 0.93; 95% CI 0.87-0.99) and high (HR 0.94; 95% CI 0.87-1.01) adherence to the score compared with those with low adherence. In this large sample of older adults from Europe and the USA, increased adherence to MD was associated with lower hip fracture incidence.

  • 4.
    Bien, Stephanie A.
    et al.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Su, Yu-Ru
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Conti, David V.
    Univ Southern Calif, USC Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA;Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Harrison, Tabitha A.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Qu, Conghui
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Guo, Xingyi
    Vanderbilt Univ, Sch Med, Div Epidemiol, Nashville, TN 37232 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Lu, Yingchang
    Vanderbilt Univ, Sch Med, Div Epidemiol, Nashville, TN 37232 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Albanes, Demetrius
    NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Auer, Paul L.
    Univ Wisconsin, Joseph J Zilber Sch Publ Hlth, Milwaukee, WI 53205 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Banbury, Barbara L.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Berndt, Sonja I.
    NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Bezieau, Stephane
    CHU Hotel Dieu, F-44093 Nantes, France;CHU Nantes, Serv Genet Med, F-44093 Nantes, France;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Brenner, Hermann
    German Canc Res Ctr, Div Clin Epidemiol & Aging Res, D-69120 Heidelberg, Germany;German Canc Res Ctr, Div Prevent Oncol, D-69120 Heidelberg, Germany;Natl Ctr Tumor Dis NCT, D-69120 Heidelberg, Germany;German Canc Consortium DKTK, D-69120 Heidelberg, Germany;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Buchanan, Daniel D.
    Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Parkville, Vic 3010, Australia;Univ Melbourne, Dept Pathol, Colorectal Oncogen Grp, Melbourne, Vic 3010, Australia;Royal Melbourne Hosp, Genet Med & Familial Canc Ctr, Parkville, Vic 3010, Australia;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Caan, Bette J.
    Kaiser Permanente Med Care Program Northern Calif, Div Res, Oakland, CA 94612 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Campbell, Peter T.
    Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Carlson, Christopher S.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Chan, Andrew T.
    Harvard Med Sch, Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02114 USA;Brigham & Womens Hosp, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA;Harvard Med Sch, Boston, MA 02115 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Chang-Claude, Jenny
    German Canc Res Ctr, Div Canc Epidemiol, Unit Genet Epidemiol, D-69120 Heidelberg, Germany;Univ Canc Ctr Hamburg, Univ Med Ctr Hamburg, Genet Tumour Epidemiol Grp, D-20246 Hamburg, Germany;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Chen, Sai
    Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Connolly, Charles M.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Easton, Douglas F.
    Univ Cambridge, Dept Publ Hlth, Cambridge, England;Univ Cambridge, Primary Care Sch Clin Med, Cambridge, England;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Feskens, Edith J. M.
    Wageningen Univ & Res, Div Human Nutr, Wageningen, Netherlands;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Gallinger, Steven
    Univ Toronto, Lunenfeld Tanenbaum Res Inst, Mt Sinai Hosp, Toronto, ON ON 1X5, Canada;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Giles, Graham G.
    Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Parkville, Vic 3010, Australia;Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic 3004, Australia;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Gunter, Marc J.
    Aarhus Univ, Sect Epidemiol, Dept Publ Hlth, Aarhus, Denmark;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Hampe, Jochen
    Univ Hosp Dresden, Med Dept 1, TU Dresden, D-01307 Dresden, Germany;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Huyghe, Jeroen R.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Hoffmeister, Michael
    German Canc Res Ctr, Div Clin Epidemiol & Aging Res, D-69120 Heidelberg, Germany;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Hudson, Thomas J.
    Ontario Inst Canc Res, Toronto, ON, Canada;AbbVie Inc, 1500 Seaport Blvd, Redwood City, CA 94063 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Jacobs, Eric J.
    Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Jenkins, Mark A.
    Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Parkville, Vic 3010, Australia;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Kampman, Ellen
    Wageningen Univ & Res, Div Human Nutr, Wageningen, Netherlands;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Kang, Hyun Min
    Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Kuehn, Tilman
    German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Kury, Sebastien
    CHU Hotel Dieu, F-44093 Nantes, France;CHU Nantes, Serv Genet Med, F-44093 Nantes, France;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Lejbkowicz, Flavio
    Natl Israeli Canc Control Ctr, Clalit Hlth Serv, IL-34361 Haifa, Israel;Carmel Hosp, Dept Community Med & Epidemiol, IL-34361 Haifa, Israel;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Le Marchand, Loic
    Univ Hawaii, Canc Ctr, Honolulu, HI 96813 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Milne, Roger L.
    Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Parkville, Vic 3010, Australia;Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic 3004, Australia;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Li, Li
    Case Western Reserve Univ, Dept Family Med & Community Hlth, Cleveland, OH 44106 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Li, Christopher I.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Lindblom, Annika
    Karolinska Univ, Hosp Solna, Dept Clin Genet, S-17177 Stockholm, Sweden;Karolinska Inst Solna, Dept Mol Med & Surg, S-17177 Stockholm, Sweden;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Lindor, Noralane M.
    Mayo Clin Arizona, Dept Hlth Sci Res, Scottsdale, AZ 85259 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Martin, Vicente
    Univ Leon, Biomed Inst IBIOMED, Leon, Spain;CIBER Epidemiol & Salud Publ CIBERESP, Madrid 28029, Spain;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    McNeil, Caroline E.
    Univ Southern Calif, USC Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Melas, Marilena
    Univ Southern Calif, USC Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Moreno, Victor
    CIBER Epidemiol & Salud Publ CIBERESP, Madrid 28029, Spain;Bellvitge Biomed Res Inst IDIBELL, Catalan Inst Oncol, Barcelona 08028, Spain;Univ Barcelona, E-08007 Barcelona, Spain;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Newcomb, Polly A.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Offit, Kenneth
    Mem Sloan Kettering Canc Ctr, Clin Genet Serv, Dept Med, New York, NY 10065 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Pharaoh, Paul D. P.
    Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge CB2 1TN, England;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Potter, John D.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Qu, Chenxu
    Univ Southern Calif, USC Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Riboli, Elio
    Imperial Coll London, Sch Publ Hlth, London, England;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Rennert, Gad
    Natl Israeli Canc Control Ctr, Clalit Hlth Serv, IL-34361 Haifa, Israel;Carmel Hosp, Dept Community Med & Epidemiol, IL-34361 Haifa, Israel;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Sala, Nuria
    Catalan Inst Oncol IDIBELL, Canc Epidemiol Res Program, Unit Nutr & Canc, Barcelona 08908, Spain;Catalan Inst Oncol IDIBELL, Mol Epidemiol Grp, Translat Res Lab, Barcelona 08908, Spain;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Schafmayer, Clemens
    Univ Hosp Schleswig Holstein, Dept Gen & Thorac Surg, Campus Kiel, D-24118 Kiel, Germany;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Scacheri, Peter C.
    Case Western Reserve Univ, Dept Genet & Genome Sci, Cleveland, OH 44106 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Schmit, Stephanie L.
    H Lee Moffitt Canc Ctr & Res Inst Inc, Dept Canc Epidemiol, Tampa, FL 33612 USA;H Lee Moffitt Canc Ctr & Res Inst Inc, Dept Gastrointestinal Oncol, Tampa, FL 33612 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Severi, Gianluca
    Inst Cancerol Gustave Roussy, Ctr Res Epidemiol & Populat Hlth, Villejuif, France;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Slattery, Martha L.
    Univ Utah, Dept Internal Med, Salt Lake City, UT 84112 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Smith, Joshua D.
    Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Trichopoulou, Antonia
    Hellen Hlth Fdn, 13 Kaisareias & Alexandroupoleos, Athens 11527, Greece;Univ Athens, WHO Collaborating Ctr Nutr & Hlth, Unit Nutrit Epidemiol & Nutr Publ Hlth, Dept Hyg Epidemiol & Med Stat,Med Sch, Mikras Asias 11527, Greece;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Tumino, Rosario
    Azienda Sanit Prov Ragusa, Dept Prevent, Affiliat Canc Registry, Ragusa, Italy;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Ulrich, Cornelia M.
    Huntsman Canc Inst, Populat Sci, Salt Lake City, UT 84112 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    van Duijnhoven, Franzel J. B.
    Wageningen Univ & Res, Div Human Nutr, Wageningen, Netherlands;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Van Guelpen, Bethany
    Umea Univ, Dept Med Biosci, Pathol, Umea, Sweden;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Weinstein, Stephanie J.
    NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    White, Emily
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics. Karolinska Inst Solna, Inst Environm Med, S-17177 Stockholm, Sweden;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Woods, Michael O.
    Mem Univ Newfoundland, Fac Med, Discipline Genet, St John, NF A1B 3V6, Canada;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Wu, Anna H.
    Univ Southern Calif, USC Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA;Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Abecasis, Goncalo R.
    Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Casey, Graham
    Inst Cancerol Gustave Roussy, Ctr Res Epidemiol & Populat Hlth, Villejuif, France;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Nickerson, Deborah A.
    Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Gruber, Stephen B.
    Univ Southern Calif, USC Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Hsu, Li
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Zheng, Wei
    Vanderbilt Univ, Sch Med, Div Epidemiol, Nashville, TN 37232 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA;Vanderbilt Univ, Vanderbilt Ingram Canc Ctr, Nashville, TN 37232 USA.
    Peters, Ulrike
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA;Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.
    Genetic variant predictors of gene expression provide new insight into risk of colorectal cancer2019In: Human Genetics, ISSN 0340-6717, E-ISSN 1432-1203, Vol. 138, no 4, p. 307-326Article in journal (Refereed)
    Abstract [en]

    Genome-wide association studies have reported 56 independently associated colorectal cancer (CRC) risk variants, most of which are non-coding and believed to exert their effects by modulating gene expression. The computational method PrediXcan uses cis-regulatory variant predictors to impute expression and perform gene-level association tests in GWAS without directly measured transcriptomes. In this study, we used reference datasets from colon (n=169) and whole blood (n=922) transcriptomes to test CRC association with genetically determined expression levels in a genome-wide analysis of 12,186 cases and 14,718 controls. Three novel associations were discovered from colon transverse models at FDR0.2 and further evaluated in an independent replication including 32,825 cases and 39,933 controls. After adjusting for multiple comparisons, we found statistically significant associations using colon transcriptome models with TRIM4 (discovery P=2.2x10(-4), replication P=0.01), and PYGL (discovery P=2.3x10(-4), replication P=6.7x10(-4)). Interestingly, both genes encode proteins that influence redox homeostasis and are related to cellular metabolic reprogramming in tumors, implicating a novel CRC pathway linked to cell growth and proliferation. Defining CRC risk regions as one megabase up- and downstream of one of the 56 independent risk variants, we defined 44 non-overlapping CRC-risk regions. Among these risk regions, we identified genes associated with CRC (P<0.05) in 34/44 CRC-risk regions. Importantly, CRC association was found for two genes in the previously reported 2q25 locus, CXCR1 and CXCR2, which are potential cancer therapeutic targets. These findings provide strong candidate genes to prioritize for subsequent laboratory follow-up of GWAS loci. This study is the first to implement PrediXcan in a large colorectal cancer study and findings highlight the utility of integrating transcriptome data in GWAS for discovery of, and biological insight into, risk loci.

  • 5. Campbell, Peter T
    et al.
    Newton, Christina C
    Kitahara, Cari M
    Patel, Alpa V
    Hartge, Patricia
    Koshiol, Jill
    McGlynn, Katherine A
    Adami, Hans-Olov
    Berrington de González, Amy
    Beane Freeman, Laura E
    Bernstein, Leslie
    Buring, Julie E
    Freedman, Neal D
    Gao, Yu-Tang
    Giles, Graham G
    Gunter, Marc J
    Jenab, Mazda
    Liao, Linda M
    Milne, Roger L
    Robien, Kim
    Sandler, Dale P
    Schairer, Catherine
    Sesso, Howard D
    Shu, Xiao-Ou
    Weiderpass, Elisabete
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Xiang, Yong-Bing
    Zeleniuch-Jacquotte, Anne
    Zheng, Wei
    Gapstur, Susan M
    Body Size Indicators and Risk of Gallbladder Cancer: Pooled Analysis of Individual-Level Data from 19 Prospective Cohort Studies.2017In: Cancer Epidemiology, Biomarkers and Prevention, ISSN 1055-9965, E-ISSN 1538-7755, Vol. 26, no 4, p. 597-606Article in journal (Refereed)
    Abstract [en]

    Background: There are few established risk factors for gallbladder cancer beyond gallstones. Recent studies suggest a higher risk with high body mass index (BMI), an indicator of general heaviness, but evidence from other body size measures is lacking.Methods: Associations of adult BMI, young adult BMI, height, adult weight gain, waist circumference (WC), waist-height ratio (WHtR), hip circumference (HC), and waist-hip ratio (WHR) with gallbladder cancer risk were evaluated. Individual-level data from 1,878,801 participants in 19 prospective cohort studies (14 studies had circumference measures) were harmonized and included in this analysis. Multivariable Cox proportional hazards regression estimated hazard ratios (HR) and 95% confidence intervals (CI).Results: After enrollment, 567 gallbladder cancer cases were identified during 20.1 million person-years of observation, including 361 cases with WC measures. Higher adult BMI (per 5 kg/m2, HR: 1.24; 95% CI, 1.13-1.35), young adult BMI (per 5 kg/m2, HR: 1.12; 95% CI, 1.00-1.26), adult weight gain (per 5 kg, HR: 1.07; 95% CI, 1.02-1.12), height (per 5 cm, HR: 1.10; 95% CI, 1.03-1.17), WC (per 5 cm, HR: 1.09; 95% CI, 1.02-1.17), WHtR (per 0.1 unit, HR: 1.24; 95% CI, 1.00-1.54), and HC (per 5 cm, HR: 1.13; 95% CI, 1.04-1.22), but not WHR (per 0.1 unit, HR: 1.03; 95% CI, 0.87-1.22), were associated with higher risks of gallbladder cancer, and results did not differ meaningfully by sex or other demographic/lifestyle factors.Conclusions: These findings indicate that measures of overall and central excess body weight are associated with higher gallbladder cancer risks.Impact: Excess body weight is an important, and potentially preventable, gallbladder cancer risk factor. Cancer Epidemiol Biomarkers Prev; 26(4); 597-606. ©2017 AACR.

  • 6. Carrasquilla, Germán D
    et al.
    Frumento, Paolo
    Berglund, Anita
    Borgfeldt, Christer
    Bottai, Matteo
    Chiavenna, Chiara
    Eliasson, Mats
    Engström, Gunnar
    Hallmans, Göran
    Jansson, Jan-Håkan
    Magnusson, Patrik K
    Nilsson, Peter M
    Pedersen, Nancy L
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Leander, Karin
    Postmenopausal hormone therapy and risk of stroke: A pooled analysis of data from population-based cohort studies.2017In: PLoS Medicine, ISSN 1549-1277, E-ISSN 1549-1676, Vol. 14, no 11, article id e1002445Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Recent research indicates a favourable influence of postmenopausal hormone therapy (HT) if initiated early, but not late, on subclinical atherosclerosis. However, the clinical relevance of timing of HT initiation for hard end points such as stroke remains to be determined. Further, no previous research has considered the timing of initiation of HT in relation to haemorrhagic stroke risk. The importance of the route of administration, type, active ingredient, and duration of HT for stroke risk is also unclear. We aimed to assess the association between HT and risk of stroke, considering the timing of initiation, route of administration, type, active ingredient, and duration of HT.

    METHODS AND FINDINGS: Data on HT use reported by the participants in 5 population-based Swedish cohort studies, with baseline investigations performed during the period 1987-2002, were combined in this observational study. In total, 88,914 postmenopausal women who reported data on HT use and had no previous cardiovascular disease diagnosis were included. Incident events of stroke (ischaemic, haemorrhagic, or unspecified) and haemorrhagic stroke were identified from national population registers. Laplace regression was employed to assess crude and multivariable-adjusted associations between HT and stroke risk by estimating percentile differences (PDs) with 95% confidence intervals (CIs). The fifth and first PDs were calculated for stroke and haemorrhagic stroke, respectively. Crude models were adjusted for age at baseline only. The final adjusted models included age at baseline, level of education, smoking status, body mass index, level of physical activity, and age at menopause onset. Additional variables evaluated for potential confounding were type of menopause, parity, use of oral contraceptives, alcohol consumption, hypertension, dyslipidaemia, diabetes, family history of cardiovascular disease, and cohort. During a median follow-up of 14.3 years, 6,371 first-time stroke events were recorded; of these, 1,080 were haemorrhagic. Following multivariable adjustment, early initiation (<5 years since menopause onset) of HT was associated with a longer stroke-free period than never use (fifth PD, 1.00 years; 95% CI 0.42 to 1.57), but there was no significant extension to the time period free of haemorrhagic stroke (first PD, 1.52 years; 95% CI -0.32 to 3.37). When considering timing as a continuous variable, the stroke-free and the haemorrhagic stroke-free periods were maximal if HT was initiated approximately 0-5 years from the onset of menopause. If single conjugated equine oestrogen HT was used, late initiation of HT was associated with a shorter stroke-free (fifth PD, -4.41 years; 95% CI -7.14 to -1.68) and haemorrhagic stroke-free (first PD, -9.51 years; 95% CI -12.77 to -6.24) period than never use. Combined HT when initiated late was significantly associated with a shorter haemorrhagic stroke-free period (first PD, -1.97 years; 95% CI -3.81 to -0.13), but not with a shorter stroke-free period (fifth PD, -1.21 years; 95% CI -3.11 to 0.68) than never use. Given the observational nature of this study, the possibility of uncontrolled confounding cannot be excluded. Further, immortal time bias, also related to the observational design, cannot be ruled out.

    CONCLUSIONS: When initiated early in relation to menopause onset, HT was not associated with increased risk of incident stroke, regardless of the route of administration, type of HT, active ingredient, and duration. Generally, these findings held also for haemorrhagic stroke. Our results suggest that the initiation of HT 0-5 years after menopause onset, as compared to never use, is associated with a decreased risk of stroke and haemorrhagic stroke. Late initiation was associated with elevated risks of stroke and haemorrhagic stroke when conjugated equine oestrogen was used as single therapy. Late initiation of combined HT was associated with haemorrhagic stroke risk.

  • 7. Crippa, Alessio
    et al.
    Larsson, Susanna C
    Discacciati, Andrea
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Orsini, Nicola
    Red and processed meat consumption and risk of bladder cancer: a dose-response meta-analysis of epidemiological studies.2018In: European Journal of Nutrition, ISSN 1436-6207, E-ISSN 1436-6215, Vol. 57, no 2, p. 689-701Article in journal (Refereed)
    Abstract [en]

    BACKGROUND/OBJECTIVES: Several epidemiological studies have analyzed the associations between red and processed meat and bladder cancer risk but the shape and strength of the associations are still unclear. Therefore, we conducted a dose-response meta-analysis to quantify the potential association between red and processed meat and bladder cancer risk.

    METHODS: Relevant studies were identified by searching the PubMed database through January 2016 and reviewing the reference lists of the retrieved articles. Results were combined using random-effects models.

    RESULTS: Five cohort studies with 3262 cases and 1,038,787 participants and 8 cases-control studies with 7009 cases and 27,240 participants met the inclusion criteria. Red meat was linearly associated with bladder cancer risk in case-control studies, with a pooled RR of 1.51 (95% confidence interval (CI) 1.13, 2.02) for every 100 g increase per day, while no association was observed among cohort studies (P heterogeneity across study design = 0.02). Based on both case-control and cohort studies, the pooled relative risk (RR) for every 50 g increase of processed meat per day was 1.20 (95% CI 1.06, 1.37) (P heterogeneity across study design = 0.22).

    CONCLUSIONS: This meta-analysis suggests that processed meat may be positively associated with bladder cancer risk. A positive association between red meat and risk of bladder cancer was observed only in case-control studies, while no association was observe in prospective studies.

  • 8. Dadaev, Tokhir
    et al.
    Saunders, Edward J
    Newcombe, Paul J
    Anokian, Ezequiel
    Leongamornlert, Daniel A
    Brook, Mark N
    Cieza-Borrella, Clara
    Mijuskovic, Martina
    Wakerell, Sarah
    Olama, Ali Amin Al
    Schumacher, Fredrick R
    Berndt, Sonja I
    Benlloch, Sara
    Ahmed, Mahbubl
    Goh, Chee
    Sheng, Xin
    Zhang, Zhuo
    Muir, Kenneth
    Govindasami, Koveela
    Lophatananon, Artitaya
    Stevens, Victoria L
    Gapstur, Susan M
    Carter, Brian D
    Tangen, Catherine M
    Goodman, Phyllis
    Thompson, Ian M
    Batra, Jyotsna
    Chambers, Suzanne
    Moya, Leire
    Clements, Judith
    Horvath, Lisa
    Tilley, Wayne
    Risbridger, Gail
    Gronberg, Henrik
    Aly, Markus
    Nordström, Tobias
    Pharoah, Paul
    Pashayan, Nora
    Schleutker, Johanna
    Tammela, Teuvo L J
    Sipeky, Csilla
    Auvinen, Anssi
    Albanes, Demetrius
    Weinstein, Stephanie
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Hakansson, Niclas
    West, Catharine
    Dunning, Alison M
    Burnet, Neil
    Mucci, Lorelei
    Giovannucci, Edward
    Andriole, Gerald
    Cussenot, Olivier
    Cancel-Tassin, Géraldine
    Koutros, Stella
    Freeman, Laura E Beane
    Sorensen, Karina Dalsgaard
    Orntoft, Torben Falck
    Borre, Michael
    Maehle, Lovise
    Grindedal, Eli Marie
    Neal, David E
    Donovan, Jenny L
    Hamdy, Freddie C
    Martin, Richard M
    Travis, Ruth C
    Key, Tim J
    Hamilton, Robert J
    Fleshner, Neil E
    Finelli, Antonio
    Ingles, Sue Ann
    Stern, Mariana C
    Rosenstein, Barry
    Kerns, Sarah
    Ostrer, Harry
    Lu, Yong-Jie
    Zhang, Hong-Wei
    Feng, Ninghan
    Mao, Xueying
    Guo, Xin
    Wang, Guomin
    Sun, Zan
    Giles, Graham G
    Southey, Melissa C
    MacInnis, Robert J
    FitzGerald, Liesel M
    Kibel, Adam S
    Drake, Bettina F
    Vega, Ana
    Gómez-Caamaño, Antonio
    Fachal, Laura
    Szulkin, Robert
    Eklund, Martin
    Kogevinas, Manolis
    Llorca, Javier
    Castaño-Vinyals, Gemma
    Penney, Kathryn L
    Stampfer, Meir
    Park, Jong Y
    Sellers, Thomas A
    Lin, Hui-Yi
    Stanford, Janet L
    Cybulski, Cezary
    Wokolorczyk, Dominika
    Lubinski, Jan
    Ostrander, Elaine A
    Geybels, Milan S
    Nordestgaard, Børge G
    Nielsen, Sune F
    Weisher, Maren
    Bisbjerg, Rasmus
    Røder, Martin Andreas
    Iversen, Peter
    Brenner, Hermann
    Cuk, Katarina
    Holleczek, Bernd
    Maier, Christiane
    Luedeke, Manuel
    Schnoeller, Thomas
    Kim, Jeri
    Logothetis, Christopher J
    John, Esther M
    Teixeira, Manuel R
    Paulo, Paula
    Cardoso, Marta
    Neuhausen, Susan L
    Steele, Linda
    Ding, Yuan Chun
    De Ruyck, Kim
    De Meerleer, Gert
    Ost, Piet
    Razack, Azad
    Lim, Jasmine
    Teo, Soo-Hwang
    Lin, Daniel W
    Newcomb, Lisa F
    Lessel, Davor
    Gamulin, Marija
    Kulis, Tomislav
    Kaneva, Radka
    Usmani, Nawaid
    Slavov, Chavdar
    Mitev, Vanio
    Parliament, Matthew
    Singhal, Sandeep
    Claessens, Frank
    Joniau, Steven
    Van den Broeck, Thomas
    Larkin, Samantha
    Townsend, Paul A
    Aukim-Hastie, Claire
    Gago-Dominguez, Manuela
    Castelao, Jose Esteban
    Martinez, Maria Elena
    Roobol, Monique J
    Jenster, Guido
    van Schaik, Ron H N
    Menegaux, Florence
    Truong, Thérèse
    Koudou, Yves Akoli
    Xu, Jianfeng
    Khaw, Kay-Tee
    Cannon-Albright, Lisa
    Pandha, Hardev
    Michael, Agnieszka
    Kierzek, Andrzej
    Thibodeau, Stephen N
    McDonnell, Shannon K
    Schaid, Daniel J
    Lindstrom, Sara
    Turman, Constance
    Ma, Jing
    Hunter, David J
    Riboli, Elio
    Siddiq, Afshan
    Canzian, Federico
    Kolonel, Laurence N
    Le Marchand, Loic
    Hoover, Robert N
    Machiela, Mitchell J
    Kraft, Peter
    Freedman, Matthew
    Wiklund, Fredrik
    Chanock, Stephen
    Henderson, Brian E
    Easton, Douglas F
    Haiman, Christopher A
    Eeles, Rosalind A
    Conti, David V
    Kote-Jarai, Zsofia
    Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants.2018In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 9, no 1, article id 2256Article in journal (Refereed)
    Abstract [en]

    Prostate cancer is a polygenic disease with a large heritable component. A number of common, low-penetrance prostate cancer risk loci have been identified through GWAS. Here we apply the Bayesian multivariate variable selection algorithm JAM to fine-map 84 prostate cancer susceptibility loci, using summary data from a large European ancestry meta-analysis. We observe evidence for multiple independent signals at 12 regions and 99 risk signals overall. Only 15 original GWAS tag SNPs remain among the catalogue of candidate variants identified; the remainder are replaced by more likely candidates. Biological annotation of our credible set of variants indicates significant enrichment within promoter and enhancer elements, and transcription factor-binding sites, including AR, ERG and FOXA1. In 40 regions at least one variant is colocalised with an eQTL in prostate cancer tissue. The refined set of candidate variants substantially increase the proportion of familial relative risk explained by these known susceptibility regions, which highlights the importance of fine-mapping studies and has implications for clinical risk profiling.

  • 9. Donat-Vargas, Carolina
    et al.
    Berglund, Marika
    Glynn, Anders
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Åkesson, Agneta
    Dietary polychlorinated biphenyls, long-chain n-3 polyunsaturated fatty acids and incidence of malignant melanoma.2017In: European Journal of Cancer, ISSN 0959-8049, E-ISSN 1879-0852, Vol. 72, p. 137-143, article id S0959-8049(16)32594-1Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: For malignant melanoma, other risk factors aside from sun exposure have been hardly explored. Polychlorinated biphenyls (PCBs)-mainly from fatty fish- may affect melanogenesis and promote melanoma progression, while long-chain n-3 polyunsaturated fatty acids seem to exert antineoplastic actions in melanoma cells.

    OBJECTIVES: We aimed to assess the association of validated estimates of dietary PCB exposure as well as the intake of eicosapentaenoic acid and docosahexaenoic acid (EPA-DHA), accounting for sun habits and skin type, with the risk of malignant melanoma in middle-aged and elderly women.

    METHODS: We included 20,785 women at baseline in 2009 from the prospective population-based Swedish Mammography Cohort. Validated estimates of dietary PCB exposure and EPA-DHA intake were obtained via a food frequency questionnaire. Incident melanoma cases were ascertained through register-linkage.

    RESULTS: During 4.5 years of follow-up, we ascertained 67 incident cases of melanoma. After multivariable adjustments, exposure to dietary PCBs was associated with four-fold increased risk of malignant melanoma (hazard ratio [HR], 4.0 [95% confidence interval {CI}, 1.2-13; P for trend = 0.02]), while EPA-DHA intake was associated with 80% lower risk (HR, 0.2 [95% CI, 0.1-0.8; P for trend = 0.03]), comparing the highest exposure tertiles with the lowest.

    CONCLUSION: While we found a direct association between dietary PCB exposure and risk of melanoma, EPA-DHA intake showed to have a substantial protective association. Question of benefits and risk from fish consumption is very relevant and further prospective studies in the general population verifying these findings are warranted.

  • 10. Downer, Mary K
    et al.
    Batista, Julie L
    Mucci, Lorelei A
    Stampfer, Meir J
    Epstein, Mara Meyer
    Håkansson, Niclas
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Johansson, Jan-Erik
    Andrén, Ove
    Fall, Katja
    Andersson, Sven-Olof
    Dairy intake in relation to prostate cancer survival.2017In: International Journal of Cancer, ISSN 0020-7136, E-ISSN 1097-0215, Vol. 140, no 9, p. 2060-2069Article in journal (Refereed)
    Abstract [en]

    Dairy intake has been associated with increased risk of advanced prostate cancer. Two US cohort studies reported increased prostate cancer-specific mortality with increased high-fat milk intake. We examined whether dairy and related nutrient intake were associated with prostate cancer progression in a Swedish patient population with high dairy consumption. We prospectively followed 525 men with newly diagnosed prostate cancer (diagnosed 1989-1994). We identified and confirmed deaths through February 2011 (n = 222 prostate cancer-specific, n = 268 from other causes). Cox proportional hazards regression was used to calculate hazard ratios (HR) and 95% confidence intervals (CI) for the associations between food or nutrient intake and prostate cancer-specific death. On average, patients consumed 5.0 servings/day of total dairy products at diagnosis. In the whole population, high-fat milk intake was not associated with prostate cancer-specific death (95% CI: 0.78, 2.10; p-trend = 0.32; multivariate-adjusted model). However, among patients diagnosed with localized prostate cancer, compared to men who consumed <1 servings/day of high-fat milk, those who drank ≥3 servings/day had an increased hazard of prostate cancer mortality (HR = 6.10; 95% CI: 2.14, 17.37; p-trend = 0.004; multivariate-adjusted model). Low-fat milk intake was associated with a borderline reduction in prostate cancer death among patients with localized prostate cancer. These associations were not observed among patients diagnosed with advanced stage prostate cancer. Our data suggest a positive association between high-fat milk intake and prostate cancer progression among patients diagnosed with localized prostate cancer. Further studies are warranted to investigate this association and elucidate the mechanisms by which high-fat milk intake may promote prostate cancer progression.

  • 11.
    Dörk, Thilo
    et al.
    Hannover Med Sch, Gynaecol Res Unit, Hannover, Germany.
    Peterlongo, Paolo
    IFOM FIRC Inst Mol Oncol, Genome Diagnost Program, Milan, Italy.
    Mannermaa, Arto
    Univ Eastern Finland, Translat Canc Res Area, Kuopio, Finland;Univ Eastern Finland, Inst Clin Med Pathol & Forens Med, Kuopio, Finland;Kuopio Univ Hosp, Imaging Ctr, Dept Clin Pathol, Kuopio, Finland.
    Bolla, Manjeet K.
    Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England.
    Wang, Qin
    Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England.
    Dennis, Joe
    Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England.
    Ahearn, Thomas
    NCI, Div Canc Epidemiol & Genet, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA.
    Andrulis, Irene L.
    Lunenfeld Tanenbaum Res Inst Mt Sinai Hosp, Fred A Litwin Ctr Canc Genet, Toronto, ON, Canada;Univ Toronto, Dept Mol Genet, Toronto, ON, Canada.
    Anton-Culver, Hoda
    Univ Calif Irvine, Dept Epidemiol, Genet Epidemiol Res Inst, Irvine, CA USA.
    Arndt, Volker
    German Canc Res Ctr, Div Clin Epidemiol & Aging Res, C070, Heidelberg, Germany.
    Aronson, Kristan J.
    Queens Univ, Dept Publ Hlth Sci, Kingston, ON, Canada;Queens Univ, Canc Res Inst, Kingston, ON, Canada.
    Augustinsson, Annelie
    Lund Univ, Dept Canc Epidemiol, Clin Sci, Lund, Sweden.
    Freeman, Laura E. Beane
    NCI, Div Canc Epidemiol & Genet, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA.
    Beckmann, Matthias W.
    Friedrich Alexander Univ Erlangen Nuremberg, Univ Hosp Erlangen, Comprehens Canc Ctr ER EMN, Dept Gynecol & Obstet, Erlangen, Germany.
    Beeghly-Fadiel, Alicia
    Vanderbilt Univ, Sch Med, Vanderbilt Ingram Canc Ctr, Div Epidemiol,Dept Med,Vanderbilt Epidemiol Ctr, Nashville, TN 37212 USA.
    Behrens, Sabine
    German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany.
    Bermisheva, Marina
    Russian Acad Sci, Ufa Fed Res Ctr, Inst Biochem & Genet, Ufa, Russia.
    Blomqvist, Carl
    Univ Helsinki, Helsinki Univ Hosp, Dept Oncol, Helsinki, Finland;Orebro Univ Hosp, Dept Oncol, Orebro, Sweden.
    Bogdanova, Natalia, V
    Hannover Med Sch, Gynaecol Res Unit, Hannover, Germany;Hannover Med Sch, Dept Radiat Oncol, Hannover, Germany;NN Alexandrov Res Inst Oncol & Med Radiol, Minsk, BELARUS.
    Bojesen, Stig E.
    Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Copenhagen Gen Populat Study, Herlev, Denmark;Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Dept Clin Biochem, Herlev, Denmark;Univ Copenhagen, Fac Hlth & Med Sci, Copenhagen, Denmark.
    Brauch, Hiltrud
    Dr Margarete Fischer Bosch Inst Clin Pharmacol, Stuttgart, Germany;German Canc Res Ctr, German Canc Consortium DKTK, Heidelberg, Germany;Univ Tubingen, iFIT Cluster Excellence, Tubingen, Germany.
    Brenner, Hermann
    German Canc Res Ctr, Div Clin Epidemiol & Aging Res, C070, Heidelberg, Germany;German Canc Res Ctr, German Canc Consortium DKTK, Heidelberg, Germany;German Canc Res Ctr, Div Prevent Oncol, Heidelberg, Germany;Natl Ctr Tumor Dis NCT, Heidelberg, Germany.
    Burwinkel, Barbara
    German Canc Res Ctr, Mol Epidemiol Grp, C080, Heidelberg, Germany;Heidelberg Univ, Univ Womens Clin Heidelberg, Mol Biol Breast Canc, Heidelberg, Germany.
    Canzian, Federico
    German Canc Res Ctr, Genom Epidemiol Grp, Heidelberg, Germany.
    Chan, Tsun L.
    Canc Genet Ctr, Hong Kong Hereditary Breast Canc Family Registry, Happy Valley, Hong Kong, Peoples R China;Hong Kong Sanat & Hosp, Dept Pathol, Happy Valley, Hong Kong, Peoples R China.
    Chang-Claude, Jenny
    German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany;Univ Med Ctr Hamburg Eppendorf, UCCH, Canc Epidemiol Grp, Hamburg, Germany.
    Chanock, Stephen J.
    NCI, Div Canc Epidemiol & Genet, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA.
    Choi, Ji-Yeob
    Seoul Natl Univ, Dept Biomed Sci, Grad Sch, Seoul, South Korea;Seoul Natl Univ, Canc Res Inst, Seoul, South Korea.
    Christiansen, Hans
    Hannover Med Sch, Dept Radiat Oncol, Hannover, Germany.
    Clarke, Christine L.
    Univ Sydney, Westmead Inst Med Res, Sydney, NSW, Australia.
    Couch, Fergus J.
    Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA.
    Czene, Kamila
    Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
    Daly, Mary B.
    Fox Chase Canc Ctr, Dept Clin Genet, 7701 Burholme Ave, Philadelphia, PA 19111 USA.
    dos-Santos-Silva, Isabel
    London Sch Hyg & Trop Med, Dept Noncommunicable Dis Epidemiol, London, England.
    Dwek, Miriam
    Univ Westminster, Fac Sci & Technol, Dept Biomed Sci, London, England.
    Eccles, Diana M.
    Univ Southampton, Canc SciencesAcad Unit, Fac Med, Southampton, Hants, England.
    Ekici, Arif B.
    Friedrich Alexander Univ Erlangen Nuremberg, Univ Hosp Erlangen, Comprehens Canc Ctr Erlangen EMN, Inst Human Genet, Erlangen, Germany.
    Eriksson, Mikael
    Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
    Evans, D. Gareth
    Univ Manchester, Manchester Acad Hlth Sci Ctr, Fac Biol, Sch Biol Sci,Div Evolut & Genom Sci, Manchester, Lancs, England;Manchester Univ Hosp NHS Fdn Trust, St Marys Hosp, Manchester Acad Hlth Sci Ctr, Manchester Ctr Genom Med, Manchester, Lancs, England.
    Fasching, Peter A.
    Friedrich Alexander Univ Erlangen Nuremberg, Univ Hosp Erlangen, Comprehens Canc Ctr ER EMN, Dept Gynecol & Obstet, Erlangen, Germany;Univ Calif Los Angeles, Dept Med, David Geffen Sch Med, Div Hematol & Oncol, Los Angeles, CA 90024 USA.
    Figueroa, Jonine
    NCI, Div Canc Epidemiol & Genet, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA;Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Med Sch, Edinburgh, Midlothian, Scotland;Canc Res UK Edinburgh Ctr, Edinburgh, Midlothian, Scotland.
    Flyger, Henrik
    Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Dept Breast Surg, Herlev, Denmark.
    Fritschisl, Lin
    Curtin Univ, Sch Publ Hlth, Perth, WA, Australia.
    Gabrielson, Marike
    Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
    Gago-Dominguez, Manuela
    Complejo Hosp Univ Santiago, SERGAS, Inst Invest Sanitaria Santiago de Compostela IDIS, Genom Med Grp,Galician Fdn Genom Med, Santiago De Compostela, Spain;Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA.
    Gao, Chi
    Harvard TH Chan Sch Publ Hlth, Program Genet Epidemiol & Stat Genet, Boston, MA USA;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.
    Gapstur, Susan M.
    Amer Canc Soc, Behav & Epidemiol Res Grp, Atlanta, GA 30329 USA.
    Garcia-Closas, Montserrat
    NCI, Div Canc Epidemiol & Genet, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA;Inst Canc Res, Div Genet & Epidemiol, London, England.
    Garcia-Saenz, Jose A.
    Ctr Invest Biomed Red Canc CIBERONC, Inst Invest Sanitaria San Carlos IdISSC, Hosp Clin San Carlos, Med Oncol Dept, Madrid, Spain.
    Gaudet, Mia M.
    Amer Canc Soc, Behav & Epidemiol Res Grp, Atlanta, GA 30329 USA.
    Giles, Graham G.
    Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia;Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia;Monash Univ, Dept Epidemiol & Prevent Med, Melbourne, Vic, Australia.
    Goldberg, Mark S.
    McGill Univ, Dept Med, Montreal, PQ, Canada;McGill Univ, Royal Victoria Hosp, Div Clin Epidemiol, Montreal, PQ, Canada.
    Goldgar, David E.
    Univ Utah, Sch Med, Huntsman Canc Inst, Dept Dermatol, Salt Lake City, UT USA.
    Guenel, Pascal
    Univ Paris Sud, Univ Paris Saclay, INSERM, Canc & Environm Grp,Ctr Res Epidemiol & Populat H, Villejuif, France.
    Haeberle, Lothar
    Friedrich Alexander Univ Erlangen Nuremberg, Comprehens Canc Ctr Erlangen EMN, Univ Hosp Erlangen, Dept Gynaecol & Obstet, Erlangen, Germany.
    Haiman, Christopher A.
    Univ Southern Calif, Dept Prevent Med, Keck Sch Med, Los Angeles, CA USA.
    Hakansson, Niclas
    Karolinska Inst, Inst Environm Med, Stockholm, Sweden.
    Hall, Per
    Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden;Soder Sjukhuset, Dept Oncol, Stockholm, Sweden.
    Hamann, Ute
    German Canc Res Ctr, Mol Genet Breast Canc, Heidelberg, Germany.
    Hartman, Mikael
    Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore;Natl Univ Hlth Syst, Dept Surg, Singapore, Singapore.
    Hauke, Jan
    Univ Cologne, Fac Med, Ctr Familial Breast & Ovarian Canc, Cologne, Germany;Univ Cologne, Univ Hosp Cologne, Cologne, Germany;Univ Cologne, Fac Med, CMMC, Cologne, Germany;Univ Cologne, Fac Med, CIO, Cologne, Germany.
    Hein, Alexander
    Friedrich Alexander Univ Erlangen Nuremberg, Univ Hosp Erlangen, Comprehens Canc Ctr ER EMN, Dept Gynecol & Obstet, Erlangen, Germany.
    Hillemanns, Peter
    Hannover Med Sch, Gynaecol Res Unit, Hannover, Germany.
    Hogervorst, Frans B. L.
    Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Family Canc Clin, Amsterdam, Netherlands.
    Hooning, Maartje J.
    Erasmus MC Canc Inst, Dept Med Oncol, Family Canc Clin, Rotterdam, Netherlands.
    Hopper, John L.
    Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia.
    Howell, Tony
    Univ Manchester, Div Canc Sci, Manchester, Lancs, England.
    Huo, Dezheng
    Univ Chicago, Ctr Clin Canc Genet, Chicago, IL 60637 USA.
    Ito, Hidemi
    Aichi Canc Ctr Res Inst, Div Canc Epidemiol & Prevent, Nagoya, Aichi, Japan;Nagoya Univ, Div Canc Epidemiol, Grad Sch Med, Nagoya, Aichi, Japan.
    Iwasaki, Motoki
    Natl Canc Ctr, Ctr Publ Hlth Sci, Div Epidemiol, Tokyo, Japan.
    Jakubowska, Anna
    Pomeranian Med Univ, Dept Genet & Pathol, Szczecin, Poland;Pomeranian Med Univ, Lab Mol Biol & Genet Diagnost, Szczecin, Poland.
    Janni, Wolfgang
    Univ Hosp Ulm, Dept Gynaecol & Obstet, Ulm, Germany.
    John, Esther M.
    Stanford Univ, Sch Med, Stanford Canc Inst, Div Oncol,Dept Med, Stanford, CA USA.
    Jung, Audrey
    German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany.
    Kaaks, Rudolf
    German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany.
    Kang, Daehee
    Seoul Natl Univ, Dept Biomed Sci, Grad Sch, Seoul, South Korea;Seoul Natl Univ, Canc Res Inst, Seoul, South Korea;Seoul Natl Univ, Dept Prevent Med, Coll Med, Seoul, South Korea.
    Kapoor, Pooja Middha
    German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany;Heidelberg Univ, Fac Med, Heidelberg, Germany.
    Khusnutdinova, Elza
    Russian Acad Sci, Ufa Fed Res Ctr, Inst Biochem & Genet, Ufa, Russia;Bashkir State Univ, Dept Genet & Fundamental Med, Ufa, Russia.
    Kim, Sung-Won
    Daer St Marys Hosp, Dept Surg, Seoul, South Korea.
    Kitahara, Cari M.
    NCI, Radiat Epidemiol Branch, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
    Koutros, Stella
    NCI, Div Canc Epidemiol & Genet, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA.
    Kraft, Peter
    Harvard TH Chan Sch Publ Hlth, Program Genet Epidemiol & Stat Genet, Boston, MA USA;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.
    Kristensen, Vessela N.
    Oslo Univ Hosp, Radiumhosp, Inst Canc Res, Dept Canc Genet, Oslo, Norway;Univ Oslo, Fac Med, Inst Clin Med, Oslo, Norway.
    Kwon, Ava
    Canc Genet Ctr, Hong Kong Hereditary Breast Canc Family Registry, Happy Valley, Hong Kong, Peoples R China;Univ Hong Kong, Dept Surg, Pok Fu Lam, Hong Kong, Peoples R China;Hong Kong Sanat & Hosp, Dept Surg, Happy Valley, Hong Kong, Peoples R China.
    Lambrechts, Diether
    VIB, VIB Ctr Canc Biol, Leuven, Belgium;Univ Leuven, Dept Human Genet, Lab Translat Genet, Leuven, Belgium.
    Le Marchand, Loic
    Univ Hawaii, Epidemiol Program, Canc Ctr, Honolulu, HI 96822 USA.
    Li, Jingmei
    Genome Inst Singapore, Human Genet Div, Singapore, Singapore.
    Lindstrom, Sara
    Univ Washington, Dept Epidemiol, Sch Publ Hlth, Seattle, WA 98195 USA;Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.
    Linet, Martha
    NCI, Radiat Epidemiol Branch, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
    Lo, Wing-Yee
    Dr Margarete Fischer Bosch Inst Clin Pharmacol, Stuttgart, Germany;Univ Tubingen, Tubingen, Germany.
    Long, Jirong
    Vanderbilt Univ, Sch Med, Vanderbilt Ingram Canc Ctr, Div Epidemiol,Dept Med,Vanderbilt Epidemiol Ctr, Nashville, TN 37212 USA.
    Lophatananon, Artitaya
    Univ Manchester, Fac Biol Med & Hlth, Sch Hlth Sci, Div Populat Hlth,Hlth Serv Res & Primary Care, Manchester, Lancs, England.
    Lubinski, Jan
    Pomeranian Med Univ, Dept Genet & Pathol, Szczecin, Poland.
    Manoochehri, Mehdi
    German Canc Res Ctr, Mol Genet Breast Canc, Heidelberg, Germany.
    Manoukian, Siranoush
    Fdn IRCCS Ist Nazl Tumori Milano, Dept Med Oncol & Hematol, Unit Med Genet, Milan, Italy.
    Margolin, Sara
    Soder Sjukhuset, Dept Oncol, Stockholm, Sweden;Karolinska Inst, Sodersjukhuset, Dept Clin Sci & Educ, Stockholm, Sweden.
    Martinez, Elena
    Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA;Univ Calif San Diego, Dept Family Med & Publ Hlth, La Jolla, CA 92093 USA.
    Matsuo, Keitaro
    Aichi Canc Ctr Res Inst, Div Canc Epidemiol & Prevent, Nagoya, Aichi, Japan;Nagoya Univ, Div Canc Epidemiol, Grad Sch Med, Nagoya, Aichi, Japan.
    Mavroudis, Dimitris
    Univ Hosp Heraklion, Dept Med Oncol, Iraklion, Greece.
    Meindl, Alfons
    Ludwig Maximilian Univ Munich, Dept Gynecol & Obstet, Munich, Germany.
    Menon, Usha
    UCL, Inst Clin Trials & Methodol, MRC Clin Trials Unit, London, England.
    Milne, Roger L.
    Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia;Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia;Monash Univ, Sch Clin Sci, Precis Med, Monash Hlth, Clayton, Vic, Australia.
    Taib, Nur Aishah Mohd
    Univ Malaya, UM Canc Res Inst, Breast Canc Res Unit, Med Ctr, Kuala Lumpur, Malaysia.
    Muir, Kenneth
    Univ Warwick, Warwick Med Sch, Div Hlth Sci, Coventry, W Midlands, England;Univ Manchester, Fac Biol Med & Hlth, Sch Hlth Sci, Div Populat Hlth,Hlth Serv Res & Primary Care, Manchester, Lancs, England.
    Mulligan, Anna Marie
    Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada;Univ Hlth Network, Lab Med Program, Toronto, ON, Canada.
    Neuhausen, Susan L.
    City Hope Natl Med Ctr, Dept Populat Sci, Beckman Res Inst, Duarte, CA USA.
    Nevanlinna, Heli
    Univ Helsinki, Helsinki Univ Hosp, Dept Obstet & Gynecol, Helsinki, Finland.
    Neven, Patrick
    Univ Hosp Leuven, Leuven Multidisciplinary Breast Ctr, Leuven Canc Inst, Dept OfOncol, Leuven, Belgium.
    Newman, William G.
    Univ Manchester, Manchester Acad Hlth Sci Ctr, Fac Biol, Sch Biol Sci,Div Evolut & Genom Sci, Manchester, Lancs, England;Manchester Univ Hosp NHS Fdn Trust, St Marys Hosp, Manchester Acad Hlth Sci Ctr, Manchester Ctr Genom Med, Manchester, Lancs, England.
    Offit, Kenneth
    Mem Sloan Kettering Canc Ctr, Clin Genet Res Lab, Dept Canc Biol & Genet, 1275 York Ave, New York, NY 10021 USA;Mem Sloan Kettering Canc Ctr, Dept Med, Clin Genet Serv, 1275 York Ave, New York, NY 10021 USA.
    Olopade, Olufunmilayo, I
    Univ Chicago, Ctr Clin Canc Genet, Chicago, IL 60637 USA.
    Olshan, Andrew F.
    Univ North Carolina Chapel Hill, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA;Univ North Carolina Chapel Hill, UNC Lineberger Comprehens Canc Ctr, Chapel Hill, NC USA.
    Olson, Janet E.
    Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA.
    Olsson, Hakan
    Lund Univ, Dept Canc Epidemiol, Clin Sci, Lund, Sweden.
    Park, Sue K.
    Seoul Natl Univ, Dept Biomed Sci, Grad Sch, Seoul, South Korea;Seoul Natl Univ, Canc Res Inst, Seoul, South Korea;Seoul Natl Univ, Dept Prevent Med, Coll Med, Seoul, South Korea.
    Park-Simon, Tjoung-Won
    Hannover Med Sch, Gynaecol Res Unit, Hannover, Germany.
    Peto, Julian
    London Sch Hyg & Trop Med, Dept Noncommunicable Dis Epidemiol, London, England.
    Plaseska-Karanfilska, Dijana
    Macedonian Acad Sci & Arts, Res Ctr Genet Engn & Biotechnol Georgi D Efremov, Skopje, Macedonia.
    Pohl-Rescigno, Esther
    Univ Cologne, Fac Med, Ctr Familial Breast & Ovarian Canc, Cologne, Germany;Univ Cologne, Univ Hosp Cologne, Cologne, Germany;Univ Cologne, Fac Med, CMMC, Cologne, Germany;Univ Cologne, Fac Med, CIO, Cologne, Germany.
    Presneau, Nadege
    Univ Westminster, Fac Sci & Technol, Dept Biomed Sci, London, England.
    Rack, Brigitte
    Univ Hosp Ulm, Dept Gynaecol & Obstet, Ulm, Germany.
    Radice, Paolo
    Fdn IRCCS Ist Nazl Tumori INT, Dept Res, Unit Mol Bases Genet Risk & Genet Testing, Milan, Italy.
    Rashid, Muhammad U.
    German Canc Res Ctr, Mol Genet Breast Canc, Heidelberg, Germany;Shaukat Khanum Mem Canc Hosp & Res Ctr SKMCH & RC, Dept Basic Sci, Lahore, Pakistan.
    Rennert, Gad
    Carmel Hosp, Clalit Natl Canc Control Ctr, Haifa, Israel;Technion Fac Med, Haifa, Israel.
    Rennert, Hedy S.
    Carmel Hosp, Clalit Natl Canc Control Ctr, Haifa, Israel;Technion Fac Med, Haifa, Israel.
    Romero, Atocha
    Hosp Univ Puerta Hierro, Med Oncol Dept, Madrid, Spain.
    Ruebner, Matthias
    Friedrich Alexander Univ Erlangen Nuremberg, Comprehens Canc Ctr Erlangen EMN, Univ Hosp Erlangen, Dept Gynaecol & Obstet, Erlangen, Germany.
    Saloustros, Emmanouil
    Univ Hosp Larissa, Dept Oncol, Larisa, Greece.
    Schmidt, Marjanka K.
    Antoni von Leeuwenhoek Hosp, Div Mol Pathol, Netherlands Canc Inst, Amsterdam, Netherlands;Antoni von Leeuwenhoek Hosp, Div Psychosocial Res & Epidemiol, Netherlands Canc Inst, Amsterdam, Netherlands.
    Schmutzler, Rita K.
    Univ Cologne, Fac Med, Ctr Familial Breast & Ovarian Canc, Cologne, Germany;Univ Cologne, Univ Hosp Cologne, Cologne, Germany;Univ Cologne, Fac Med, CMMC, Cologne, Germany;Univ Cologne, Fac Med, CIO, Cologne, Germany.
    Schneider, Michael O.
    Friedrich Alexander Univ Erlangen Nuremberg, Comprehens Canc Ctr Erlangen EMN, Univ Hosp Erlangen, Dept Gynaecol & Obstet, Erlangen, Germany.
    Schoemaker, Minouk J.
    Inst Canc Res, Div Genet & Epidemiol, London, England.
    Scott, Christopher
    Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA.
    Shen, Chen-Yang
    Acad Sinica, Inst Biomed Sci, Taipei, Taiwan;China Med Univ, Sch Publ Hlth, Taichung, Taiwan.
    Shu, Xiao-Ou
    Vanderbilt Univ, Sch Med, Vanderbilt Ingram Canc Ctr, Div Epidemiol,Dept Med,Vanderbilt Epidemiol Ctr, Nashville, TN 37212 USA.
    Simard, Jacques
    Univ Laval, CHU Quebec, Res Ctr, Genom Ctr, Quebec City, PQ, Canada.
    Slager, Susan
    Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA.
    Smichkoska, Snezhana
    Ss Cyril & Methodius Univ Skopje, Med Fac, Univ Clin Radiotherapy & Oncol, Skopje, Macedonia.
    Southey, Melissa C.
    Monash Univ, Sch Clin Sci, Precis Med, Monash Hlth, Clayton, Vic, Australia;Univ Melbourne, Dept Clin Pathol, Melbourne, Vic, Australia.
    Spinelli, John J.
    BC Canc, Populat Oncol, Vancouver, BC, Canada;Univ British Columbia, Sch Populat & Publ Hlth, Vancouver, BC, Canada.
    Stone, Jennifer
    Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia;Curtin Univ, Curtin UWA Ctr Genet Origins Hlth & Dis, Perth, WA, Australia;Univ Western Australia, Perth, WA, Australia.
    Surowy, Harald
    German Canc Res Ctr, Mol Epidemiol Grp, C080, Heidelberg, Germany;Heidelberg Univ, Univ Womens Clin Heidelberg, Mol Biol Breast Canc, Heidelberg, Germany.
    Swerdlow, Anthony J.
    Inst Canc Res, Div Genet & Epidemiol, London, England;Inst Canc Res, Div Breast Canc Res, London, England.
    Tamimi, Rulla M.
    Harvard TH Chan Sch Publ Hlth, Program Genet Epidemiol & Stat Genet, Boston, MA USA;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA;Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA;Harvard Med Sch, Boston, MA 02115 USA.
    Tapper, William J.
    Univ Southampton, Fac Med, Southampton, Hants, England.
    Teo, Soo H.
    Univ Malaya, UM Canc Res Inst, Breast Canc Res Unit, Med Ctr, Kuala Lumpur, Malaysia;Canc Res Malaysia, Subang Jaya, Selangor, Malaysia.
    Terry, Mary Beth
    Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY USA.
    Toland, Amanda E.
    Ohio State Univ, Dept Canc Biol & Genet, Columbus, OH 43210 USA.
    Tollenaar, Rob A. E. M.
    Leiden Univ, Dept Surg, Med Ctr, Leiden, Netherlands.
    Torres, Diana
    German Canc Res Ctr, Mol Genet Breast Canc, Heidelberg, Germany;Pontificia Univ Javeriana, Inst Human Genet, Bogota, Colombia.
    Torres-Mejia, Gabriela
    Natl Inst Publ Hlth, Ctr Populat Hlth Res, Mexico City, DF, Mexico.
    Troester, Melissa A.
    Univ North Carolina Chapel Hill, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA;Univ North Carolina Chapel Hill, UNC Lineberger Comprehens Canc Ctr, Chapel Hill, NC USA.
    Truong, Therese
    Univ Paris Sud, Univ Paris Saclay, INSERM, Canc & Environm Grp,Ctr Res Epidemiol & Populat H, Villejuif, France.
    Tsugane, Shoichiro
    Natl Canc Ctr, Ctr Publ Hlth Sci, Tokyo, Japan.
    Untch, Michael
    Helios Clin Berlin Buch, Dept Gynecol & Obstet, Berlin, Germany.
    Vachon, Celine M.
    Mayo Clin, Div Epidemiol, Dept Hlth Sci Res, Rochester, MN USA.
    van den Ouweland, Ans M. W.
    Erasmus MC, Dept Clin Genet, Rotterdam, Netherlands.
    van Veen, Elke M.
    Univ Manchester, Manchester Acad Hlth Sci Ctr, Fac Biol, Sch Biol Sci,Div Evolut & Genom Sci, Manchester, Lancs, England;Manchester Univ Hosp NHS Fdn Trust, St Marys Hosp, Manchester Acad Hlth Sci Ctr, Manchester Ctr Genom Med, Manchester, Lancs, England.
    Vijai, Joseph
    Mem Sloan Kettering Canc Ctr, Clin Genet Res Lab, Dept Canc Biol & Genet, 1275 York Ave, New York, NY 10021 USA;Mem Sloan Kettering Canc Ctr, Dept Med, Clin Genet Serv, 1275 York Ave, New York, NY 10021 USA.
    Wendt, Camilla
    Karolinska Inst, Sodersjukhuset, Dept Clin Sci & Educ, Stockholm, Sweden.
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics. Karolinska Inst, Inst Environm Med, Stockholm, Sweden.
    Yu, Jyh-Cherng
    Triserv Gen Hosp, Natl Def Med Ctr, Dept Surg, Taipei, Taiwan.
    Zheng, Wei
    Vanderbilt Univ, Sch Med, Vanderbilt Ingram Canc Ctr, Div Epidemiol,Dept Med,Vanderbilt Epidemiol Ctr, Nashville, TN 37212 USA.
    Ziogas, Argyrios
    Univ Calif Irvine, Dept Epidemiol, Genet Epidemiol Res Inst, Irvine, CA USA.
    Ziv, Elad
    Univ Calif San Francisco, UCSF Helen Diller Family Comprehens Canc Ctr, Inst Human Genet, Dept Med, San Francisco, CA 94143 USA.
    Dunning, Alison M.
    Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Oncol, Cambridge, England.
    Pharoah, Paul D. P.
    Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England;Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Oncol, Cambridge, England.
    Schindler, Detlev
    Univ Wurzburg, Bioctr, Inst Human Genet, Wurzburg, Germany.
    Devilee, Peter
    Leiden Univ, Dept Pathol, Med Ctr, Leiden, Netherlands;Leiden Univ, Dept Human Genet, Med Ctr, Leiden, Netherlands.
    Easton, Douglas F.
    Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England;Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Oncol, Cambridge, England.
    Balleine, Rosemary
    Pathol West ICPMR, Sydney, NSW, Australia.
    Baxter, Robert
    Univ Sydney, Royal North Shore Hosp, Kollig Inst Med Res, Sydney, NSW, Australia.
    Braye, Stephen
    John Hunter Hosp, Pathol North, Newcastle, NSW, Australia.
    Carpenter, Jane
    Univ Sydney, Westmead Inst Med Res, Sydney, NSW, Australia.
    Dahlstrom, Jane
    Canberra Hosp, Dept Anat Pathol, ACT Pathol, Canberra, ACT, Australia;Australian Natl Univ, ANU Med Sch, Canberra, ACT, Australia.
    Forbes, John
    Univ Newcastle, Dept Surg Oncol, Calvary Mater Newcastle Hosp, Australian New Zealand Breast Canc Trials Grp, Newcastle, NSW, Australia;Univ Newcastle, Sch Med & Publ Hlth, Newcastle, NSW, Australia.
    Lee, C. Soon
    Univ Western Sydney, Sch Sci & Hlth, Sydney, NSW, Australia.
    Marsh, Deborah
    Univ Sydney, Royal North Shore Hosp, Kolling Inst Med Res, Hormones & Canc Grp, Sydney, NSW, Australia.
    Morey, Adrienne
    Syd Path St Vincents Hosp, Sydney, NSW, Australia.
    Pathmanathan, Nirmala
    Westmead Hosp, Westmead Breast Canc Inst, Dept Tissue Pathol & Diagnost Oncol, Pathol West, Sydney, NSW, Australia.
    Scott, Rodney
    Hunter Med Res Inst, Ctr Informat Based Med, Newcastle, NSW, Australia;Univ Newcastle, Fac Hlth, Prior Res Ctr Canc, Sch Biomed Sci & Pharm, Newcastle, NSW, Australia.
    Simpson, Peter
    Univ Queensland, UQ Ctr Clin Res & Sch Med, Brisbane, Qld, Australia.
    Spigelman, Allan
    St Vincents Hosp, Kinghorn Canc Ctr, Hereditary Canc Clin, Sydney, NSW, Australia.
    Wilcken, Nicholas
    Westmead Hosp, Crown Princess Mary Canc Ctr, Sydney, NSW, Australia;Univ Sydney, Sydney Med Sch Westmead, Sydney, NSW, Australia.
    Yip, Desmond
    Australian Natl Univ, ANU Med Sch, Canberra, ACT, Australia;Canberra Hosp, Dept Med Oncol, Canberra, ACT, Australia.
    Zeps, Nikolajs
    St John God Perth Northern Hosp, Perth, WA, Australia.
    Borresen-Dale, Anne-Lise
    Oslo Univ Hosp, Radiumhosp, Inst Canc Res, Dept Canc Genet, Oslo, Norway;Univ Oslo, Fac Med, Inst Clin Med, Oslo, Norway.
    Alnaes, Grethe I. Grenaker
    Oslo Univ Hosp, Radiumhosp, Inst Canc Res, Dept Canc Genet, Oslo, Norway.
    Sahlberg, Kristine K.
    Oslo Univ Hosp, Radiumhosp, Inst Canc Res, Dept Canc Genet, Oslo, Norway;Vestre Viken Hosp, Dept Res, Drammen, Norway;Oslo Univ Hosp, Breast Canc Res Consortium, Oslo, Norway.
    Ottestad, Lars
    Oslo Univ Hosp, Radiumhosp, Inst Canc Res, Dept Canc Genet, Oslo, Norway.
    Karesen, Rolf
    Univ Oslo, Fac Med, Inst Clin Med, Oslo, Norway;Oslo Univ Hosp Ulleval, Div Surg Canc & Transplantat Med, Dept Canc, Sect Breast & Endocrine Surg, Oslo, Norway.
    Schlichting, Ellen
    Oslo Univ Hosp Ulleval, Div Surg Canc & Transplantat Med, Dept Canc, Sect Breast & Endocrine Surg, Oslo, Norway.
    Holmen, Marit Muri
    Oslo Univ Hosp, Dept Radiol & Nucl Med, Oslo, Norway.
    Sauer, Toril
    Univ Oslo, Fac Med, Inst Clin Med, Oslo, Norway;Akershus Univ Hosp, Dept Pathol, Lorenskog, Norway.
    Haakensen, Vilde
    Oslo Univ Hosp, Radiumhosp, Inst Canc Res, Dept Canc Genet, Oslo, Norway.
    Engebraten, Olav
    Univ Oslo, Fac Med, Inst Clin Med, Oslo, Norway;Oslo Univ Hosp, Inst Canc Res, Dept Tumor Biol, Oslo, Norway;Oslo Univ Hosp, Dept Oncol, Div Surg Canc & Transplantat Med, Radiumhosp, Oslo, Norway.
    Naume, Bjorn
    Univ Oslo, Fac Med, Inst Clin Med, Oslo, Norway;Oslo Univ Hosp, Dept Oncol, Div Surg Canc & Transplantat Med, Radiumhosp, Oslo, Norway.
    Fossa, Alexander
    Oslo Univ Hosp, Dept Oncol, Div Surg Canc & Transplantat Med, Radiumhosp, Oslo, Norway;Oslo Univ Hosp, Natl Advisory Unit Late Effects Canc Treatment, Radiumhosp, Oslo, Norway.
    Kiserud, Cecile E.
    Oslo Univ Hosp, Dept Oncol, Div Surg Canc & Transplantat Med, Radiumhosp, Oslo, Norway;Oslo Univ Hosp, Natl Advisory Unit Late Effects Canc Treatment, Radiumhosp, Oslo, Norway.
    Reinertsen, Kristin, V
    Oslo Univ Hosp, Dept Oncol, Div Surg Canc & Transplantat Med, Radiumhosp, Oslo, Norway;Oslo Univ Hosp, Natl Advisory Unit Late Effects Canc Treatment, Radiumhosp, Oslo, Norway.
    Helland, Aslaug
    Oslo Univ Hosp, Radiumhosp, Inst Canc Res, Dept Canc Genet, Oslo, Norway;Oslo Univ Hosp, Dept Oncol, Div Surg Canc & Transplantat Med, Radiumhosp, Oslo, Norway.
    Riis, Margit
    Oslo Univ Hosp Ulleval, Div Surg Canc & Transplantat Med, Dept Canc, Sect Breast & Endocrine Surg, Oslo, Norway.
    Geisler, Juergen
    Univ Oslo, Fac Med, Inst Clin Med, Oslo, Norway;Akershus Univ Hosp, Dept Oncol, Lorenskog, Norway.
    Two truncating variants in FANCC and breast cancer risk2019In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 9, article id 12524Article in journal (Refereed)
    Abstract [en]

    Fanconi anemia (FA) is a genetically heterogeneous disorder with 22 disease-causing genes reported to date. In some FA genes, monoallelic mutations have been found to be associated with breast cancer risk, while the risk associations of others remain unknown. The gene for FA type C, FANCC, has been proposed as a breast cancer susceptibility gene based on epidemiological and sequencing studies. We used the Oncoarray project to genotype two truncating FANCC variants (p.R185X and p.R548X) in 64,760 breast cancer cases and 49,793 controls of European descent. FANCC mutations were observed in 25 cases (14 with p.R185X, 11 with p.R548X) and 26 controls (18 with p.R185X, 8 with p.R548X). There was no evidence of an association with the risk of breast cancer, neither overall (odds ratio 0.77, 95% CI 0.44-1.33, p = 0.4) nor by histology, hormone receptor status, age or family history. We conclude that the breast cancer risk association of these two FANCC variants, if any, is much smaller than for BRCA1, BRCA2 or PALB2 mutations. If this applies to all truncating variants in FANCC it would suggest there are differences between FA genes in their roles on breast cancer risk and demonstrates the merit of large consortia for clarifying risk associations of rare variants.

  • 12. Farvid, Maryam S
    et al.
    Stern, Mariana C
    Norat, Teresa
    Sasazuki, Shizuka
    Vineis, Paolo
    Weijenberg, Matty P
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Wu, Kana
    Stewart, Bernard W
    Cho, Eunyoung
    Consumption of red and processed meat and breast cancer incidence: A systematic review and meta-analysis of prospective studies.2018In: International Journal of Cancer, ISSN 0020-7136, E-ISSN 1097-0215, Vol. 143, no 11, p. 2787-2799Article in journal (Refereed)
    Abstract [en]

    = 44.4%). In addition, we identified two nested case-control studies evaluating the association between red meat and breast cancer stratified by N-acetyltransferase 2 acetylator genotype. We did not observe any association among those with either fast (per 25 g/day pooled odds ratio (OR), 1.18; 95%CI, 0.93-1.50) or slow N-acetyltransferase 2 acetylators (per 25 g/day pooled OR, 0.99; 95%CI, 0.91-1.08). In the prospective observational studies, high processed meat consumption was associated with increased breast cancer risk.

  • 13. Ferro, Ana
    et al.
    Morais, Samantha
    Rota, Matteo
    Pelucchi, Claudio
    Bertuccio, Paola
    Bonzi, Rossella
    Galeone, Carlotta
    Zhang, Zuo-Feng
    Matsuo, Keitaro
    Ito, Hidemi
    Hu, Jinfu
    Johnson, Kenneth C
    Yu, Guo-Pei
    Palli, Domenico
    Ferraroni, Monica
    Muscat, Joshua
    Malekzadeh, Reza
    Ye, Weimin
    Song, Huan
    Zaridze, David
    Maximovitch, Dmitry
    Aragonés, Nuria
    Castaño-Vinyals, Gemma
    Vioque, Jesus
    Navarrete-Muñoz, Eva M
    Pakseresht, Mohammadreza
    Pourfarzi, Farhad
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Orsini, Nicola
    Bellavia, Andrea
    Håkansson, Niclas
    Mu, Lina
    Pastorino, Roberta
    Kurtz, Robert C
    Derakhshan, Mohammad H
    Lagiou, Areti
    Lagiou, Pagona
    Boffetta, Paolo
    Boccia, Stefania
    Negri, Eva
    La Vecchia, Carlo
    Peleteiro, Bárbara
    Lunet, Nuno
    Tobacco smoking and gastric cancer:: meta-analyses of published data versus pooled analyses of individual participant data (StoP Project).2018In: European Journal of Cancer Prevention, ISSN 0959-8278, E-ISSN 1473-5709, Vol. 27, no 3, p. 197-204Article in journal (Refereed)
    Abstract [en]

    Tobacco smoking is one of the main risk factors for gastric cancer, but the magnitude of the association estimated by conventional systematic reviews and meta-analyses might be inaccurate, due to heterogeneous reporting of data and publication bias. We aimed to quantify the combined impact of publication-related biases, and heterogeneity in data analysis or presentation, in the summary estimates obtained from conventional meta-analyses. We compared results from individual participant data pooled-analyses, including the studies in the Stomach Cancer Pooling (StoP) Project, with conventional meta-analyses carried out using only data available in previously published reports from the same studies. From the 23 studies in the StoP Project, 20 had published reports with information on smoking and gastric cancer, but only six had specific data for gastric cardia cancer and seven had data on the daily number of cigarettes smoked. Compared to the results obtained with the StoP database, conventional meta-analyses overvalued the relation between ever smoking (summary odds ratios ranging from 7% higher for all studies to 22% higher for the risk of gastric cardia cancer) and yielded less precise summary estimates (SE ≤2.4 times higher). Additionally, funnel plot asymmetry and corresponding hypotheses tests were suggestive of publication bias. Conventional meta-analyses and individual participant data pooled-analyses reached similar conclusions on the direction of the association between smoking and gastric cancer. However, published data tended to overestimate the magnitude of the effects, possibly due to publication biases and limited the analyses by different levels of exposure or cancer subtypes.

  • 14.
    Ferro, Ana
    et al.
    Univ Porto, Inst Saude Publ, EPIUnit, Rua Taipas 135, P-4050600 Porto, Portugal.
    Morais, Samantha
    Univ Porto, Inst Saude Publ, EPIUnit, Rua Taipas 135, P-4050600 Porto, Portugal.
    Rota, Matteo
    Univ Milan, Dept Biomed & Clin Sci, Milan, Italy;Univ Milan, Dept Clin Sci & Community Hlth DISCCO, Milan, Italy.
    Pelucchi, Claudio
    Univ Milan, Dept Clin Sci & Community Hlth DISCCO, Milan, Italy.
    Bertuccio, Paola
    Univ Milan, Dept Clin Sci & Community Hlth DISCCO, Milan, Italy.
    Bonzi, Rossella
    Univ Milan, Dept Clin Sci & Community Hlth DISCCO, Milan, Italy.
    Galeone, Carlotta
    Univ Milan, Dept Clin Sci & Community Hlth DISCCO, Milan, Italy.
    Zhang, Zuo-Feng
    UCLA, Dept Epidemiol, Fielding Sch Publ Hlth, Los Angeles, CA USA;Jonsson Comprehens Canc Ctr, Los Angeles, CA 90034 USA.
    Matsuo, Keitaro
    Aichi Canc Ctr, Div Mol Med, Res Inst, Nagoya, Aichi, Japan.
    Ito, Hidemi
    Aichi Canc Ctr, Div Mol Med, Res Inst, Nagoya, Aichi, Japan.
    Hu, Jinfu
    Harbin Med Univ, Dept Epidemiol, Harbin, Heilongjiang, Peoples R China.
    Johnson, Kenneth C.
    Univ Ottawa, Fac Med, Sch Epidemiol Publ Hlth & Prevent Med, Ottawa, ON, Canada.
    Yu, Guo-Pei
    Peking Univ, Med Informat Ctr, Beijing, Peoples R China.
    Palli, Domenico
    ISPO, Canc Res & Prevent Inst, Mol & Nutr Epidemiol Unit, Florence, Italy.
    Ferraroni, Monica
    Univ Milan, Dept Clin Sci & Community Hlth DISCCO, Milan, Italy.
    Muscat, Joshua
    Penn State Univ, Coll Med, Penn State Hershey Med Ctr, Dept Publ Hlth Sci, Hershey, PA USA.
    Malekzadeh, Reza
    Univ Tehran Med Sci, Digest Dis Res Inst, Digest Oncol Res Ctr, Tehran, Iran.
    Ye, Weimin
    Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
    Song, Huan
    Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden;Univ Iceland, Fac Med, Ctr Publ Hlth Sci, Reykjavik, Iceland.
    Zaridze, David
    Russian NN Blokhin Canc Res Ctr, Dept Epidemiol & Prevent, Moscow, Russia.
    Maximovitch, Dmitry
    Russian NN Blokhin Canc Res Ctr, Dept Epidemiol & Prevent, Moscow, Russia.
    Fernandez de Larrea, Nerea
    Inst Salud Carlos III, Natl Ctr Epidemiol, Environm & Canc Epidemiol Unit, Madrid, Spain;CIBERESP, Madrid, Spain.
    Kogevinas, Manolis
    CIBERESP, Madrid, Spain;Ctr Res Environm Epidemiol CREAL, ISGlobal, Barcelona, Spain;Hosp del Mar, Med Res Inst, IMIM, Barcelona, Spain;UPF, Barcelona, Spain.
    Vioque, Jesus
    Miguel Hernandez Univ, Campus San Juan, Alicante, Spain;ISABIAL FISABIO Fdn, Campus San Juan, Alicante, Spain.
    Navarrete-Munoz, Eva M.
    Miguel Hernandez Univ, Campus San Juan, Alicante, Spain;ISABIAL FISABIO Fdn, Campus San Juan, Alicante, Spain.
    Pakseresht, Mohammadreza
    Univ Tehran Med Sci, Digest Dis Res Inst, Digest Oncol Res Ctr, Tehran, Iran;Univ Alberta, Dept Agr Food & Nutr Sci, Edmonton, AB, Canada;Univ Leeds, Ctr Epidemiol & Biostat, Nutr Epidemiol Grp, Leeds, W Yorkshire, England.
    Pourfarzi, Farhad
    Univ Tehran Med Sci, Digest Dis Res Inst, Digest Oncol Res Ctr, Tehran, Iran;Ardabil Univ Med Sci, Digest Dis Res Ctr, Ardebil, Iran.
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics. Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol, Stockholm, Sweden.
    Orsini, Nicola
    Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol, Stockholm, Sweden.
    Bellavia, Andrea
    Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol, Stockholm, Sweden.
    Håkansson, Niclas
    Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol, Stockholm, Sweden.
    Mu, Lina
    Univ Buffalo, Sch Publ Hlth & Hlth Profess, Dept Epidemiol & Environm Hlth, Buffalo, NY USA.
    Pastorino, Roberta
    Univ Cattolica Sacro Cuore, IRCCS Fdn Policlin Agostino Gemelli, Inst Publ Hlth, Sect Hyg, Lgo F Vito 1, I-00168 Rome, Italy.
    Kurtz, Robert C.
    Mem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA.
    Derakhshan, Mohammad H.
    Univ Tehran Med Sci, Digest Dis Res Inst, Digest Oncol Res Ctr, Tehran, Iran;Univ Glasgow, Inst Cardiovasc & Med Sci, Glasgow, Lanark, Scotland.
    Lagiou, Areti
    Athens Technol Educ Inst, Sch Hlth Profess, Dept Publ Hlth & Community Hlth, Athens, Greece.
    Lagiou, Pagona
    Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, Athens, Greece;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.
    Boffetta, Paolo
    Icahn Sch Med Mt Sinai, Tisch Canc Inst, New York, NY 10029 USA.
    Boccia, Stefania
    Univ Cattolica Sacro Cuore, IRCCS Fdn Policlin Agostino Gemelli, Inst Publ Hlth, Sect Hyg, Lgo F Vito 1, I-00168 Rome, Italy.
    Negri, Eva
    Univ Milan, Dept Biomed & Clin Sci, Milan, Italy.
    La Vecchia, Carlo
    Univ Milan, Dept Clin Sci & Community Hlth DISCCO, Milan, Italy.
    Peleteiro, Barbara
    Univ Porto, Inst Saude Publ, EPIUnit, Rua Taipas 135, P-4050600 Porto, Portugal;Univ Porto, Fac Med, Dept Ciencias Saude Publ & Forenses & Educ Med, Al Prof Hernani Monteiro, P-4200319 Porto, Portugal.
    Lunet, Nuno
    Univ Porto, Inst Saude Publ, EPIUnit, Rua Taipas 135, P-4050600 Porto, Portugal;Univ Porto, Fac Med, Dept Ciencias Saude Publ & Forenses & Educ Med, Al Prof Hernani Monteiro, P-4200319 Porto, Portugal.
    Alcohol intake and gastric cancer: Meta-analyses of published data versus individual participant data pooled analyses (StoP Project)2018In: Cancer Epidemiology, ISSN 1877-7821, E-ISSN 1877-783X, Vol. 54, p. 125-132Article in journal (Refereed)
    Abstract [en]

    Background: Individual participant data pooled analyses allow access to non-published data and statistical reanalyses based on more homogeneous criteria than meta-analyses based on systematic reviews. We quantified the impact of publication-related biases and heterogeneity in data analysis and presentation in summary estimates of the association between alcohol drinking and gastric cancer.

    Methods: We compared estimates obtained from conventional meta-analyses, using only data available in published reports from studies that take part in the Stomach Cancer Pooling (StoP) Project, with individual participant data pooled analyses including the same studies.

    Results: A total of 22 studies from the StoP Project assessed the relation between alcohol intake and gastric cancer, 19 had specific data for levels of consumption and 18 according to cancer location; published reports addressing these associations were available from 18, 5 and 5 studies, respectively. The summary odds ratios [OR, (95%CI)] estimate obtained with published data for drinkers vs. non-drinkers was 10% higher than the one obtained with individual StoP data [18 vs. 22 studies: 1.21 (1.07-1.36) vs. 1.10 (0.99-1.23)] and more heterogeneous (1(2): 63.6% vs 54.4%). In general, published data yielded less precise summary estimates (standard errors up to 2.6 times higher). Funnel plot analysis suggested publication bias.

    Conclusion: Meta-analyses of the association between alcohol drinking and gastric cancer tended to overestimate the magnitude of the effects, possibly due to publication bias. Additionally, individual participant data pooled analyses yielded more precise estimates for different levels of exposure or cancer subtypes.

  • 15. Gaudet, Mia M
    et al.
    Carter, Brian D
    Brinton, Louise A
    Falk, Roni T
    Gram, Inger T
    Luo, Juhua
    Milne, Roger L
    Nyante, Sarah J
    Weiderpass, Elisabete
    Beane Freeman, Laura E
    Sandler, Dale P
    Robien, Kim
    Anderson, Kristin E
    Giles, Graham G
    Chen, Wendy Y
    Feskanich, Diane
    Braaten, Tonje
    Isaacs, Claudine
    Butler, Lesley M
    Koh, Woon-Puay
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Adami, Hans-Olov
    White, Emily
    Margolis, Karen L
    Thun, Michael J
    Gapstur, Susan M
    Pooled analysis of active cigarette smoking and invasive breast cancer risk in 14 cohort studies.2017In: International Journal of Epidemiology, ISSN 0300-5771, E-ISSN 1464-3685, Vol. 46, no 3, p. 881-893Article in journal (Refereed)
    Abstract [en]

    Background: The 2014 US Surgeon General's report noted research gaps necessary to determine a causal relationship between active cigarette smoking and invasive breast cancer risk, including the role of alcohol consumption, timing of exposure, modification by menopausal status and heterogeneity by oestrogen receptor (ER) status.

    Methods: To address these issues, we pooled data from 14 cohort studies contributing 934 681 participants (36 060 invasive breast cancer cases). Cox proportional hazard regression models were used to calculate multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs).

    Results: Smoking duration before first birth was positively associated with risk ( P -value for trend = 2 × 10 -7 ) with the highest HR for initiation >10 years before first birth (HR = 1.18, CI 1.12-1.24). Effect modification by current alcohol consumption was evident for the association with smoking duration before first birth ( P -value=2×10 -4 ); compared with never-smoking non-drinkers, initiation >10 years before first birth was associated with risk in every category of alcohol intake, including non-drinkers (HR = 1.15, CI 1.04-1.28) and those who consumed at least three drinks per day (1.85, 1.55-2.21). Associations with smoking before first birth were limited to risk of ER+ breast cancer ( P -value for homogeneity=3×10 -3 ). Other smoking timing and duration characteristics were associated with risk even after controlling for alcohol, but were not associated with risk in non-drinkers. Effect modification by menopause was not evident.

    Conclusions: Smoking, particularly if initiated before first birth, was modestly associated with ER+ breast cancer risk that was not confounded by amount of adult alcohol intake. Possible links with breast cancer provide additional motivation for young women to not initiate smoking.

  • 16. Gaudet, Mia M
    et al.
    Gierach, Gretchen L
    Carter, Brian D
    Luo, Juhua
    Milne, Roger L
    Weiderpass, Elisabete
    Giles, Graham G
    Tamimi, Rulla M
    Eliassen, A Heather
    Rosner, Bernard
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Adami, Hans-Olov
    Margolis, Karen L
    Gapstur, Susan M
    Garcia-Closas, Montserrat
    Brinton, Louise A
    Pooled Analysis of Nine Cohorts Reveals Breast Cancer Risk Factors by Tumor Molecular Subtype.2018In: Cancer Research, ISSN 0008-5472, E-ISSN 1538-7445, Vol. 78, no 20, p. 6011-6021Article in journal (Refereed)
    Abstract [en]

    Various subtypes of breast cancer defined by estrogen receptor (ER), progesterone receptor (PR), and HER2 exhibit etiologic differences in reproductive factors, but associations with other risk factors are inconsistent. To clarify etiologic heterogeneity, we pooled data from nine cohort studies. Multivariable, joint Cox proportional hazards regression models were used to estimate HRs and 95% confidence intervals (CI) for molecular subtypes. Of 606,025 women, 11,741 invasive breast cancers with complete tissue markers developed during follow-up: 8,700 luminal A–like (ER+ or PR+/HER2), 1,368 luminal B–like (ER+ or PR+/HER2+), 521 HER2-enriched (ER/PR/HER2+), and 1,152 triple-negative (ER/PR/HER2) disease. Ever parous compared with never was associated with lower risk of luminal A–like (HR, 0.78; 95% CI, 0.73–0.83) and luminal B–like (HR, 0.74; 95% CI, 0.64–0.87) as well as a higher risk of triple-negative disease (HR, 1.23; 95% CI, 1.02–1.50; P value for overall tumor heterogeneity < 0.001). Direct associations with luminal-like, but not HER2-enriched or triple-negative, tumors were found for age at first birth, years between menarche and first birth, and age at menopause (P value for overall tumor heterogeneity < 0.001). Age-specific associations with baseline body mass index differed for risk of luminal A–like and triple-negative breast cancer (P value for tumor heterogeneity = 0.02). These results provide the strongest evidence for etiologic heterogeneity of breast cancer to date from prospective studies.

    Significance: These findings comprise the largest study of prospective data to date and contribute to the accumulating evidence that etiological heterogeneity exists in breast carcinogenesis. Cancer Res; 78(20); 6011–21. ©2018 AACR.

    .

  • 17. Gref, A
    et al.
    Rautiainen, S
    Gruzieva, O
    Håkansson, N
    Kull, I
    Pershagen, G
    Wickman, M
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Melén, E
    Bergström, A
    Dietary total antioxidant capacity in early school age and subsequent allergic disease.2017In: Clinical and Experimental Allergy, ISSN 0954-7894, E-ISSN 1365-2222, Vol. 47, no 6, p. 751-759Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Dietary antioxidant intake has been hypothesized to influence the development of allergic diseases; however, few prospective studies have investigated this association.

    OBJECTIVE: Our aim was to study the association between total antioxidant capacity (TAC) of the diet at age 8 years and the subsequent development of asthma, rhinitis and sensitization to inhalant allergens between 8 and 16 years, and to assess potential effect modification by known risk factors.

    METHODS: A total of 2359 children from the Swedish birth cohort BAMSE were included. Dietary TAC at age 8 years was estimated by combining information on the child's diet the past 12 months from a food frequency questionnaire with a database of common foods analysed with the oxygen radical absorbance capacity method. Classification of asthma and rhinitis was based on questionnaires, and serum IgE antibodies were measured at 8 and 16 years.

    RESULTS: A statistically significant inverse association was observed between TAC of the diet and incident sensitization to inhalant allergens (adjusted odds ratio: 0.73, 95% confidence interval: 0.55-0.97 for the third compared to the first tertile, P-value for trend = 0.031). Effect modification by traffic-related air pollution exposure was observed, with a stronger association between dietary TAC and sensitization among children with low traffic-related air pollution exposure (P-value for interaction = 0.029). There was no evidence for effect modification by GSTP1 or TNF genotypes, although these results should be interpreted with caution. No clear associations were observed between TAC and development of rhinitis or asthma, although a significant inverse association was observed for allergic asthma (ORadj 0.57, 95% CI 0.34-0.94).

    CONCLUSIONS AND CLINICAL RELEVANCE: Higher TAC of the diet in early school age may decrease the risk of developing sensitization to inhalant allergens from childhood to adolescence. These findings indicate that implementing an antioxidant-rich diet in childhood may contribute to the prevention of allergic disease.

  • 18.
    Huyghe, Jeroen R.
    et al.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.
    Bien, Stephanie A.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.
    Harrison, Tabitha A.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.
    Kang, Hyun Min
    Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA;Univ Michigan, Ctr Stat Genet, Ann Arbor, MI 48109 USA.
    Chen, Sai
    Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA;Univ Michigan, Ctr Stat Genet, Ann Arbor, MI 48109 USA.
    Schmit, Stephanie L.
    H Lee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, Tampa, FL USA.
    Conti, David V.
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, USC Norris Comprehens Canc Ctr, Los Angeles, CA USA.
    Qu, Conghui
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.
    Jeon, Jihyoun
    Univ Michigan, Dept Epidemiol, Ann Arbor, MI 48109 USA.
    Edlund, Christopher K.
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, USC Norris Comprehens Canc Ctr, Los Angeles, CA USA.
    Greenside, Peyton
    Stanford Univ, Biomed Informat Program, Stanford, CA 94305 USA.
    Wainberg, Michael
    Stanford Univ, Dept Comp Sci, Stanford, CA 94305 USA.
    Schumacher, Fredrick R.
    Case Western Reserve Univ, Dept Populat & Quantitat Hlth Sci, Cleveland, OH 44106 USA.
    Smith, Joshua D.
    Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA.
    Levine, David M.
    Univ Washington, Dept Biostat, Seattle, WA 98195 USA.
    Nelson, Sarah C.
    Univ Washington, Dept Biostat, Seattle, WA 98195 USA.
    Sinnott-Armstrong, Nasa A.
    Stanford Univ, Dept Genet, Stanford, CA 94305 USA.
    Albanes, Demetrius
    NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.
    Alonso, M. Henar
    Catalan Inst Oncol IDIBELL, Canc Prevent & Control Program, Barcelona, Spain;CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain;Univ Barcelona, Dept Clin Sci, Fac Med, Barcelona, Spain.
    Anderson, Kristin
    Univ Minnesota, Div Epidemiol & Community Hlth, Minneapolis, MN USA.
    Arnau-Collell, Coral
    Univ Barcelona, Dept Gastroenterol, Hosp Clin, Inst Invest Biomed August Pi & Sunyer IDIBAPS,Ctr, Barcelona, Spain.
    Arndt, Volker
    German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany.
    Bamia, Christina
    Hellen Hlth Fdn, Athens, Greece;Univ Athens, WHO Collaborating Ctr Nutr & Hlth, Unit Nutr Epidemiol & Nutr Publ Hlth, Dept Hyg Epidemiol & Med Stat,Sch Med, Athens, Greece.
    Banbury, Barbara L.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.
    Baron, John A.
    Univ N Carolina, Dept Med, Sch Med, Chapel Hill, NC 27515 USA.
    Berndt, Sonja I.
    NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.
    Bezieau, Stephane
    Ctr Hosp Univ CHU Nantes, Serv Genet Med, Nantes, France.
    Bishop, D. Timothy
    St Jamess Univ Leeds, Leeds Inst Med Res, Leeds, W Yorkshire, England.
    Boehm, Juergen
    Univ Utah, Huntsman Canc Inst, Salt Lake City, UT USA;Univ Utah, Dept Populat Hlth Sci, Salt Lake City, UT USA.
    Boeing, Heiner
    German Inst Human Nutr Potsdam Rehbrucke, Dept Epidemiol, Potsdam, Germany.
    Brenner, Hermann
    German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany;German Canc Res Ctr, Div Prevent Oncol, Heidelberg, Germany;Natl Ctr Tumor Dis NCT, Heidelberg, Germany;German Canc Res Ctr, German Canc Consortium DKTK, Heidelberg, Germany.
    Brezina, Stefanie
    Med Univ Vienna, Inst Canc Res, Dept Med 1, Vienna, Austria.
    Buch, Stephan
    Tech Univ Dresden, Dept Med 1, Univ Hosp Dresden, Dresden, Germany.
    Buchanan, Daniel D.
    Univ Melbourne, Colorectal Oncogen Grp, Dept Clin Pathol, Parkville, Vic, Australia;Univ Melbourne, Ctr Canc Res, Victorian Comprehens Canc Ctr, Parkville, Vic, Australia;Royal Melbourne Hosp, Genom Med & Family Canc Clin, Parkville, Vic, Australia.
    Burnett-Hartman, Andrea
    Kaiser Permanente Colorado, Inst Hlth Res, Denver, CO USA.
    Butterbach, Katja
    German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany.
    Caan, Bette J.
    Kaiser Permanente Med Care Program, Div Res, Oakland, CA 94611 USA.
    Campbell, Peter T.
    Amer Canc Soc, Behav & Epidemiol Res Grp, Atlanta, GA 30329 USA.
    Carlson, Christopher S.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA;Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA.
    Castellvi-Bel, Sergi
    Univ Barcelona, Dept Gastroenterol, Hosp Clin, Inst Invest Biomed August Pi & Sunyer IDIBAPS,Ctr, Barcelona, Spain.
    Chan, Andrew T.
    Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02114 USA;Harvard Med Sch, Boston, MA 02114 USA;Brigham & Womens Hosp, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA;Massachusetts Gen Hosp, Clin & Translat Epidemiol Unit, Boston, MA 02114 USA;Broad Inst Harvard & MIT, Cambridge, MA USA;Harvard Univ, Dept Epidemiol, Harvard TH Chan Sch Publ Hlth, Boston, MA 02115 USA;Harvard Univ, Dept Immunol & Infect Dis, Harvard TH Chan Sch Publ Hlth, Boston, MA 02115 USA.
    Chang-Claude, Jenny
    German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany;UCCH, Canc Epidemiol Grp, Univ Med Ctr Hamburg Eppendorf, Hamburg, Germany.
    Chanock, Stephen J.
    NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.
    Chirlaque, Maria-Dolores
    CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain;Murcia Univ, Dept Epidemiol, Reg Hlth Council, IMIB Arrixaca, Murcia, Spain.
    Cho, Sang Hee
    Chonnam Natl Univ Hosp, Dept Hematol Oncol, Hwasun, South Korea.
    Connolly, Charles M.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.
    Cross, Amanda J.
    Imperial Coll London, Dept Epidemiol & Biostat, London, England;Imperial Coll London, Dept Surg & Canc, London, England.
    Cuk, Katarina
    German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany.
    Curtis, Keith R.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.
    de la Chapelle, Albert
    Ohio State Univ, Dept Canc Biol & Genet, Columbus, OH 43210 USA;Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA.
    Doheny, Kimberly F.
    Johns Hopkins Univ, Inst Med Genet, CIDR, Baltimore, MD USA.
    Duggan, David
    City Hope Natl Med Ctr, Translat Genom Res Inst, Phoenix, AZ USA.
    Easton, Douglas F.
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England;Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Oncol, Cambridge, England.
    Elias, Sjoerd G.
    Univ Utrecht, Julius Ctr Hlth Sci & Primary Care, Univ Med Ctr Utrecht, Utrecht, Netherlands.
    Elliott, Faye
    St Jamess Univ Leeds, Leeds Inst Med Res, Leeds, W Yorkshire, England.
    English, Dallas R.
    Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia;Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic, Australia.
    Feskens, Edith J. M.
    Wageningen Univ & Res, Div Human Nutr & Hlth, Wageningen, Netherlands.
    Figueiredo, Jane C.
    Cedars Sinai Med Ctr, Dept Med, Samuel Oschin Comprehens Canc Inst, Los Angeles, CA 90048 USA;Univ Southern Calif, Dept Prevent Med, Keck Sch Med, Los Angeles, CA USA.
    Fischer, Rocky
    Univ Michigan, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA.
    FitzGerald, Liesel M.
    Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic, Australia;Univ Tasmania, Menzies Inst Med Res, Hobart, Tas, Australia.
    Forman, David
    WHO, Int Agcy Res Canc, Lyon, France.
    Gala, Manish
    Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02114 USA;Harvard Med Sch, Boston, MA 02114 USA;Massachusetts Gen Hosp, Clin & Translat Epidemiol Unit, Boston, MA 02114 USA.
    Gallinger, Steven
    Univ Toronto, Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Toronto, ON, Canada.
    Gauderman, W. James
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, USC Norris Comprehens Canc Ctr, Los Angeles, CA USA.
    Giles, Graham G.
    Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia;Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic, Australia.
    Gillanders, Elizabeth
    NCI, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA.
    Gong, Jian
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.
    Goodman, Phyllis J.
    Fred Hutchinson Canc Res Ctr, SWOG Stat Ctr, 1124 Columbia St, Seattle, WA 98104 USA.
    Grady, William M.
    Fred Hutchinson Canc Res Ctr, Div Clin Res, 1124 Columbia St, Seattle, WA 98104 USA.
    Grove, John S.
    Univ Hawaii, Canc Res Ctr, Honolulu, HI 96813 USA.
    Gsur, Andrea
    Med Univ Vienna, Inst Canc Res, Dept Med 1, Vienna, Austria.
    Gunter, Marc J.
    WHO, Nutr & Metab Sect, Int Agcy Res Canc, Lyon, France.
    Haile, Robert W.
    Stanford Univ, Dept Med, Div Oncol, Stanford, CA 94305 USA.
    Hampe, Jochen
    Tech Univ Dresden, Dept Med 1, Univ Hosp Dresden, Dresden, Germany.
    Hampel, Heather
    Ohio State Univ, Ctr Comprehens Canc, Div Human Genet, Dept Internal Med, Columbus, OH 43210 USA.
    Harlid, Sophia
    Umea Univ, Dept Radiat Sci, Oncol Unit, Umea, Sweden.
    Hayes, Richard B.
    NYU, Sch Med, Div Epidemiol, Dept Populat Hlth, New York, NY USA.
    Hofer, Philipp
    Med Univ Vienna, Inst Canc Res, Dept Med 1, Vienna, Austria.
    Hoffmeister, Michael
    German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany.
    Hopper, John L.
    Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia;Seoul Natl Univ, Dept Epidemiol, Sch Publ Hlth, Seoul, South Korea;Seoul Natl Univ, Inst Hlth & Environm, Seoul, South Korea.
    Hsu, Wan-Ling
    Univ Washington, Dept Biostat, Seattle, WA 98195 USA.
    Huang, Wen-Yi
    NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.
    Hudson, Thomas J.
    Ontario Inst Canc Res, Toronto, ON, Canada.
    Hunter, David J.
    Harvard Univ, Dept Epidemiol, Harvard TH Chan Sch Publ Hlth, Boston, MA 02115 USA;Univ Oxford, Nuffield Dept Populat Hlth, Oxford, England.
    Ibanez-Sanz, Gemma
    Catalan Inst Oncol IDIBELL, Canc Prevent & Control Program, Barcelona, Spain;Bellvitge Univ Hosp, Gastroenterol Dept, Barcelona, Spain;Bellvitge Biomed Res Inst IDIBELL, Colorectal Canc Grp, ONCOBELL Program, Barcelona, Spain.
    Idos, Gregory E.
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, USC Norris Comprehens Canc Ctr, Los Angeles, CA USA.
    Ingersoll, Roxann
    Johns Hopkins Univ, Inst Med Genet, CIDR, Baltimore, MD USA.
    Jackson, Rebecca D.
    Ohio State Univ, Dept Med, Div Endocrinol Diabet & Metab, Columbus, OH 43210 USA.
    Jacobs, Eric J.
    Amer Canc Soc, Behav & Epidemiol Res Grp, Atlanta, GA 30329 USA.
    Jenkins, Mark A.
    Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia.
    Joshi, Amit D.
    Harvard Med Sch, Boston, MA 02114 USA;Massachusetts Gen Hosp, Clin & Translat Epidemiol Unit, Boston, MA 02114 USA;Harvard Univ, Dept Epidemiol, Harvard TH Chan Sch Publ Hlth, Boston, MA 02115 USA.
    Joshu, Corinne E.
    Johns Hopkins Univ, Dept Epidemiol, Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA.
    Keku, Temitope O.
    Univ N Carolina, Ctr Gastrointestinal Biol & Dis, Chapel Hill, NC 27515 USA.
    Key, Timothy J.
    Univ Oxford, Canc Epidemiol Unit, Nuffield Dept Populat Hlth, Oxford, England.
    Kim, Hyeong Rok
    Chonnam Natl Univ, Dept Surg, Hwasun Hosp & Med Sch, Hwasun, South Korea.
    Kobayashi, Emiko
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.
    Kolonel, Laurence N.
    Univ Hawaii Manoa, Off Publ Hlth Studies, Honolulu, HI 96822 USA.
    Kooperberg, Charles
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.
    Kuehn, Tilman
    German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany.
    Kury, Sebastien
    Ctr Hosp Univ CHU Nantes, Serv Genet Med, Nantes, France.
    Kweon, Sun-Seog
    Chonnam Natl Univ, Sch Med, Dept Prevent Med, Gwangju, South Korea;Chonnam Natl Univ, Jeonnam Reg Canc Ctr, Hwasun Hosp, Hwasun, South Korea.
    Larsson, Susanna C.
    Karolinska Inst, Inst Environm Med, Stockholm, Sweden.
    Laurie, Cecelia A.
    Univ Washington, Dept Biostat, Seattle, WA 98195 USA.
    Le Marchand, Loic
    Univ Hawaii, Canc Res Ctr, Honolulu, HI 96813 USA.
    Leal, Suzanne M.
    Baylor Coll Med, Ctr Stat Genet, Dept Mol & Human Genet, Houston, TX 77030 USA.
    Lee, Soo Chin
    Natl Univ, Inst Canc, Dept Haematol Oncol, Singapore, Singapore;Natl Univ Singapore, Canc Sci Inst Singapore, Singapore, Singapore.
    Lejbkowicz, Flavio
    Carmel, Clalit Hlth Serv, Personalized Genom Serv, Haifa, Israel;Lady Davis Carmel Med Ctr, Dept Community Med & Epidemiol, Haifa, Israel;Clalit Natl Canc Control Ctr, Haifa, Israel.
    Lemire, Mathieu
    Ontario Inst Canc Res, Toronto, ON, Canada.
    Li, Christopher I.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.
    Li, Li
    Case Western Reserve Univ, Ctr Community Hlth Integrat, Cleveland, OH 44106 USA;Case Western Reserve Univ, Case Comprehens Canc Ctr, Cleveland, OH 44106 USA.
    Lieb, Wolfgang
    Christian Albrechts Univ Kiel, Inst Epidemiol, PopGen Biobank, Kiel, Germany.
    Lin, Yi
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.
    Lindblom, Annika
    Karolinska Univ Hosp, Dept Clin Genet, Stockholm, Sweden;Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.
    Lindor, Noralane M.
    Mayo Clin, Dept Hlth Sci Res, Scottsdale, AZ USA.
    Ling, Hua
    Johns Hopkins Univ, Inst Med Genet, CIDR, Baltimore, MD USA.
    Louie, Tin L.
    Univ Washington, Dept Biostat, Seattle, WA 98195 USA.
    Mannisto, Satu
    Natl Inst Hlth & Welf, Dept Publ Hlth Solut, Helsinki, Finland.
    Markowitz, Sanford D.
    Case Western Reserve Univ, Dept Med, Case Comprehens Canc Ctr, Cleveland, OH 44106 USA;Case Western Reserve Univ, Dept Genet, Case Comprehens Canc Ctr, Cleveland, OH 44106 USA;Univ Hosp Cleveland, Cleveland, OH 44106 USA.
    Martin, Vicente
    CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain;Univ Leon, Biomed Inst IBIOMED, Leon, Spain.
    Masala, Giovanna
    Inst Canc Res Prevent & Clin Network ISPRO, Canc Risk Factors & Life Style Epidemiol Unit, Florence, Italy.
    McNeil, Caroline E.
    Univ Southern Calif, USC Norris Comprehens Canc Ctr, Los Angeles, CA USA.
    Melas, Marilena
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, USC Norris Comprehens Canc Ctr, Los Angeles, CA USA.
    Milne, Roger L.
    Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia;Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic, Australia.
    Moreno, Lorena
    Univ Barcelona, Dept Gastroenterol, Hosp Clin, Inst Invest Biomed August Pi & Sunyer IDIBAPS,Ctr, Barcelona, Spain.
    Murphy, Neil
    WHO, Nutr & Metab Sect, Int Agcy Res Canc, Lyon, France.
    Myte, Robin
    Umea Univ, Dept Radiat Sci, Oncol Unit, Umea, Sweden.
    Naccarati, Alessio
    Czech Acad Sci, Dept Mol Biol Canc, Inst Expt Med, Prague, Czech Republic;IIGM, Turin, Italy.
    Newcomb, Polly A.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA;Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA.
    Offit, Kenneth
    Mem Sloan Kettering Canc Ctr, Dept Med, Clin Genet Serv, 1275 York Ave, New York, NY 10021 USA;Weill Cornell Med Coll, Dept Med, New York, NY USA.
    Ogino, Shuji
    Broad Inst Harvard & MIT, Cambridge, MA USA;Harvard Univ, Dept Epidemiol, Harvard TH Chan Sch Publ Hlth, Boston, MA 02115 USA;Harvard Med Sch, Program MPE Mol Pathol Epidemiol, Dept Pathol, Brigham & Womens Hosp, Boston, MA USA;Dana Farber Canc Inst, Dept Oncol Pathol, Boston, MA 02115 USA.
    Onland-Moret, N. Charlotte
    Univ Utrecht, Julius Ctr Hlth Sci & Primary Care, Univ Med Ctr Utrecht, Utrecht, Netherlands.
    Pardini, Barbara
    IIGM, Turin, Italy;Univ Turin, Dept Med Sci, Turin, Italy.
    Parfrey, Patrick S.
    Mem Univ, Clin Epidemiol Unit, Sch Med, St John, NF, Canada.
    Pearlman, Rachel
    Ohio State Univ, Ctr Comprehens Canc, Div Human Genet, Dept Internal Med, Columbus, OH 43210 USA.
    Perduca, Vittorio
    Univ Paris 05, Lab Math Appl MAP5, CNRS, UMR 8145, Paris, France;Univ Paris Saclay, CESP, INSERM, U1018,Fac Med,Univ Paris Sud,UVSQ,Gustave Roussy, Villejuif, France.
    Pharoah, Paul D. P.
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England.
    Pinchev, Mila
    Lady Davis Carmel Med Ctr, Dept Community Med & Epidemiol, Haifa, Israel.
    Platz, Elizabeth A.
    Johns Hopkins Univ, Dept Epidemiol, Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA.
    Prentice, Ross L.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.
    Pugh, Elizabeth
    Johns Hopkins Univ, Inst Med Genet, CIDR, Baltimore, MD USA.
    Raskin, Leon
    Vanderbilt Univ, Sch Med, Div Epidemiol, Vanderbilt Epidemiol Ctr, Nashville, TN 37212 USA.
    Rennert, Gad
    Lady Davis Carmel Med Ctr, Dept Community Med & Epidemiol, Haifa, Israel;Clalit Natl Canc Control Ctr, Haifa, Israel;Technion Israel Inst Technol, Ruth & Bruce Rappaport Fac Med, Haifa, Israel.
    Rennert, Hedy S.
    Lady Davis Carmel Med Ctr, Dept Community Med & Epidemiol, Haifa, Israel;Clalit Natl Canc Control Ctr, Haifa, Israel;Technion Israel Inst Technol, Ruth & Bruce Rappaport Fac Med, Haifa, Israel.
    Riboli, Elio
    Imperial Coll London, Sch Publ Hlth, London, England.
    Rodriguez-Barranco, Miguel
    CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain;Univ Granada, Escuela Andaluza Salud Publ, Inst Invest Biosanitaria Ibs GRANADA, Hosp Univ Granada, Granada, Spain.
    Romm, Jane
    Johns Hopkins Univ, Inst Med Genet, CIDR, Baltimore, MD USA.
    Sakoda, Lori C.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA;Kaiser Permanente Northern Calif, Div Res, Oakland, CA USA.
    Schafmayer, Clemens
    Univ Hosp Schleswig Holstein, Dept Gen & Thorac Surg, Campus Kiel, Kiel, Germany.
    Schoen, Robert E.
    Univ Pittsburgh, Med Ctr, Dept Med & Epidemiol, Pittsburgh, PA USA.
    Seminara, Daniela
    NCI, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA.
    Shah, Mitul
    Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Oncol, Cambridge, England.
    Shelford, Tameka
    Johns Hopkins Univ, Inst Med Genet, CIDR, Baltimore, MD USA.
    Shin, Min-Ho
    Chonnam Natl Univ, Sch Med, Dept Prevent Med, Gwangju, South Korea.
    Shulman, Katerina
    Hillel Yaffe Med Ctr, Oncol Unit, Hadera, Israel.
    Sieri, Sabina
    Fdn IRCCS Ist Nazl Tumori, Epidemiol & Prevent Unit, Milan, Italy.
    Slattery, Martha L.
    Univ Utah, Dept Internal Med, Salt Lake City, UT 84112 USA.
    Southey, Melissa C.
    Univ Melbourne, Genet Epidemiol Lab, Dept Pathol, Melbourne, Vic, Australia.
    Stadler, Zsofia K.
    Mem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA.
    Stegmaier, Christa
    Saarland Canc Registry, Saarbrucken, Germany.
    Su, Yu-Ru
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.
    Tangen, Catherine M.
    Fred Hutchinson Canc Res Ctr, SWOG Stat Ctr, 1124 Columbia St, Seattle, WA 98104 USA.
    Thibodeau, Stephen N.
    Mayo Clin, Div Lab Genet, Dept Lab Med & Pathol, Rochester, MN USA.
    Thomas, Duncan C.
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, USC Norris Comprehens Canc Ctr, Los Angeles, CA USA.
    Thomas, Sushma S.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.
    Toland, Amanda E.
    Ohio State Univ, Ctr Comprehens Canc, Dept Canc Biol & Genet, Columbus, OH 43210 USA;Ohio State Univ, Ctr Comprehens Canc, Dept Internal Med, Columbus, OH 43210 USA.
    Trichopoulou, Antonia
    Hellen Hlth Fdn, Athens, Greece;Univ Athens, WHO Collaborating Ctr Nutr & Hlth, Unit Nutr Epidemiol & Nutr Publ Hlth, Dept Hyg Epidemiol & Med Stat,Sch Med, Athens, Greece.
    Ulrich, Cornelia M.
    Univ Utah, Huntsman Canc Inst, Salt Lake City, UT USA;Univ Utah, Dept Populat Hlth Sci, Salt Lake City, UT USA.
    Van den Berg, David J.
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, USC Norris Comprehens Canc Ctr, Los Angeles, CA USA.
    van Duijnhoven, Franzel J. B.
    Wageningen Univ & Res, Div Human Nutr & Hlth, Wageningen, Netherlands.
    Van Guelpen, Bethany
    Umea Univ, Dept Radiat Sci, Oncol Unit, Umea, Sweden.
    van Kranen, Henk
    Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands.
    Vijai, Joseph
    Mem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA.
    Visvanathan, Kala
    Johns Hopkins Univ, Dept Epidemiol, Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA.
    Vodicka, Pavel
    Czech Acad Sci, Dept Mol Biol Canc, Inst Expt Med, Prague, Czech Republic;Charles Univ Prague, Inst Biol & Med Genet, Fac Med 1, Prague, Czech Republic;Charles Univ Prague, Fac Med, Plzen, Czech Republic;Charles Univ Prague, Biomed Ctr Pilsen, Plzen, Czech Republic.
    Vodickova, Ludmila
    Czech Acad Sci, Dept Mol Biol Canc, Inst Expt Med, Prague, Czech Republic;Charles Univ Prague, Inst Biol & Med Genet, Fac Med 1, Prague, Czech Republic;Charles Univ Prague, Fac Med, Plzen, Czech Republic;Charles Univ Prague, Biomed Ctr Pilsen, Plzen, Czech Republic.
    Vymetalkova, Veronika
    Czech Acad Sci, Dept Mol Biol Canc, Inst Expt Med, Prague, Czech Republic;Charles Univ Prague, Inst Biol & Med Genet, Fac Med 1, Prague, Czech Republic;Charles Univ Prague, Fac Med, Plzen, Czech Republic;Charles Univ Prague, Biomed Ctr Pilsen, Plzen, Czech Republic.
    Weigl, Korbinian
    German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany;German Canc Res Ctr, German Canc Consortium DKTK, Heidelberg, Germany;Heidelberg Univ, Med Fac, Heidelberg, Germany.
    Weinstein, Stephanie J.
    NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.
    White, Emily
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.
    Win, Aung Ko
    Royal Melbourne Hosp, Genom Med & Family Canc Clin, Parkville, Vic, Australia;Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia.
    Wolf, C. Roland
    Univ Dundee, Sch Med, Dundee, Scotland.
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics. Karolinska Inst, Inst Environm Med, Stockholm, Sweden.
    Woods, Michael O.
    Mem Univ Newfoundland, Discipline Genet, St John, NF, Canada.
    Wu, Anna H.
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, USC Norris Comprehens Canc Ctr, Los Angeles, CA USA.
    Zaidi, Syed H.
    Ontario Inst Canc Res, Toronto, ON, Canada.
    Zanke, Brent W.
    Univ Toronto, Div Hematol, Toronto, ON, Canada.
    Zhang, Qing
    Fred Hutchinson Canc Res Ctr, Genom Shared Resource, 1124 Columbia St, Seattle, WA 98104 USA.
    Zheng, Wei
    Vanderbilt Univ, Sch Med, Div Epidemiol, Dept Med,Vanderbilt Ingram Canc Ctr,Vanderbilt Ep, Nashville, TN 37212 USA.
    Scacheri, Peter C.
    Case Western Reserve Univ, Sch Med, Dept Genet & Genome Sci, Case Comprehens Canc Ctr, Cleveland, OH USA.
    Potter, John D.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.
    Bassik, Michael C.
    Stanford Univ, Dept Genet, Stanford, CA 94305 USA.
    Kundaje, Anshul
    Stanford Univ, Dept Comp Sci, Stanford, CA 94305 USA;Stanford Univ, Dept Genet, Stanford, CA 94305 USA.
    Casey, Graham
    Univ Virginia, Ctr Publ Hlth Genom, Charlottesville, VA USA.
    Moreno, Victor
    Catalan Inst Oncol IDIBELL, Canc Prevent & Control Program, Barcelona, Spain;CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain;Univ Barcelona, Dept Clin Sci, Fac Med, Barcelona, Spain;Bellvitge Biomed Res Inst IDIBELL, Colorectal Canc Grp, ONCOBELL Program, Barcelona, Spain.
    Abecasis, Goncalo R.
    Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA;Univ Michigan, Ctr Stat Genet, Ann Arbor, MI 48109 USA.
    Nickerson, Deborah A.
    Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA.
    Gruber, Stephen B.
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, USC Norris Comprehens Canc Ctr, Los Angeles, CA USA.
    Hsu, Li
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA;Univ Washington, Dept Biostat, Seattle, WA 98195 USA.
    Peters, Ulrike
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA;Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA.
    Discovery of common and rare genetic risk variants for colorectal cancer2019In: Nature Genetics, ISSN 1061-4036, E-ISSN 1546-1718, Vol. 51, no 1, p. 76-87Article in journal (Refereed)
    Abstract [en]

    To further dissect the genetic architecture of colorectal cancer (CRC), we performed whole-genome sequencing of 1,439 cases and 720 controls, imputed discovered sequence variants and Haplotype Reference Consortium panel variants into genome-wide association study data, and tested for association in 34,869 cases and 29,051 controls. Findings were followed up in an additional 23,262 cases and 38,296 controls. We discovered a strongly protective 0.3% frequency variant signal at CHD1. In a combined meta-analysis of 125,478 individuals, we identified 40 new independent signals at P < 5 x 10(-8), bringing the number of known independent signals for CRC to similar to 100. New signals implicate lower-frequency variants, Kruppel-like factors, Hedgehog signaling, Hippo-YAP signaling, long noncoding RNAs and somatic drivers, and support a role for immune function. Heritability analyses suggest that CRC risk is highly polygenic, and larger, more comprehensive studies enabling rare variant analysis will improve understanding of biology underlying this risk and influence personalized screening strategies and drug development.

  • 19.
    Jiang, Xia
    et al.
    Harvard TH Chan Sch Publ Hlth, Program Genet Epidemiol & Stat Genet, 677 Huntington Ave, Boston, MA 02115 USA;Karolinska Inst, Inst Environm Med, Unit Cardiovasc Epidemiol, Nobels Vagen 13, S-17177 Stockholm, Sweden.
    Finucane, Hilary K.
    Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, 677 Huntington Ave, Boston, MA 02115 USA;Broad Inst MIT & Harvard, Program Med & Populat Genet, 75 Ames St, Cambridge, MA 02142 USA.
    Schumacher, Fredrick R.
    Case Western Reserve Univ, Dept Populat & Quantitat Hlth Sci, 10900 Eucid Ave, Cleveland, OH 44106 USA;Univ Hosp, Seidman Canc Ctr, Cleveland, OH 44106 USA.
    Schmit, Stephanie L.
    H Lee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, 12902 Magnolia Dr MRC CANCONT, Tampa, FL 33612 USA;H Lee Moffitt Canc Ctr & Res Inst, Dept Gastrointestinal Oncol, 12902 Magnolia Dr MRC CANCONT, Tampa, FL 33612 USA.
    Tyrer, Jonathan P.
    Univ Cambridge, Dept Oncol, Ctr Canc Genet Epidemiol, 2 Worts Causeway, Cambridge CB1 8RN, England.
    Han, Younghun
    Geisel Sch Med Dartmouth, Dept Biomed Data Sci, 1 Med Ctr Dr, Dartmouth, NS, Lebanon.
    Michailidou, Kyriaki
    Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, 2 Worts Causeway, Cambridge CB1 8RN, England;Cyprus Inst Neurol & Genet, Dept Elect Microscopy Mol Pathol, CY-1683 Nicosia, Cyprus.
    Lesseur, Corina
    Int Agcy Res Canc, Genet Epidemiol Grp, 150 Cours Albert Thomas, F-69008 Lyon, France;Int Agcy Res Canc, Sect Genet, 150 Cours Albert Thomas, F-69008 Lyon, France.
    Kuchenbaecker, Karoline B.
    UCL, Div Psychiat, Maple House,149 Tottenham Court Rd, London W1T 7NF, England;UCL, UCL Genet Inst, Gower St, London WC1E 6BT, England.
    Dennis, Joe
    Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, 2 Worts Causeway, Cambridge CB1 8RN, England.
    Conti, David V.
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Norris Comprehens Canc Ctr, Los Angeles, CA 48109 USA.
    Casey, Graham
    Univ Virginia, Publ Hlth Sci, POB 800717, Charlottesville, VI 80071 USA;Univ Virginia, Ctr Publ Hlth Genom, POB 800717, Charlottesville, VI 80071 USA.
    Gaudet, Mia M.
    Amer Canc Soc, Epidemiol Res Program, 250 Williams St NW, Atlanta, GA 30303 USA.
    Huyghe, Jeroen R.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1100 Fairview Ave N, Seattle, WA 98109 USA.
    Albanes, Demetrius
    NCI, Div Canc Epidemiol & Genet, 9609 Med Ctr Dr, Rockville, MD 20850 USA.
    Aldrich, Melinda C.
    Vanderbilt Univ, Div Epidemiol, Dept Thorac Surg, Med Ctr, 609 Oxford House, Nashville, TN 37232 USA.
    Andrew, Angeline S.
    Dartmouth Hitchcock Med Ctr, Dept Neurol, 7927 Rubin Bldg,Room 860,One Med Ctr Dr, Lebanon, NH 3756 USA.
    Andrulis, Irene L.
    Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Fred ALitwin Ctr Canc Genet, 600 Univ Ave, Toronto, ON M5G 1X5, Canada;Univ Toronto, Dept Mol Genet, 1 Kings Coll Circle, Toronto, ON M5S 1A8, Canada.
    Anton-Culver, Hoda
    Univ Calif Irvine, Genet Epidemiol Res Inst, Dept Epidemiol, 224 Irvine Hall, Irvine, CA 92617 USA.
    Antoniou, Antonis C.
    Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, 2 Worts Causeway, Cambridge CB1 8RN, England.
    Antonenkova, Natalia N.
    NNAlexandrov Res Inst Oncol & Med Radiol, Settlement Lesnoy 2, Minsk 223040, BELARUS.
    Arnold, Susanne M.
    Univ Kentucky, Markey Canc Ctr, 800 Rose St,Cc445, Lexington, KY 40508 USA.
    Aronson, Kristan J.
    Queens Univ, Dept Publ Hlth Sci, 10 Stuart St, Kingston, ON K7L 3N6, Canada;Queens Univ, Canc Res Inst, 10 Stuart St, Kingston, ON K7L 3N6, Canada.
    Arun, Banu K.
    Univ Texas MD Anderson Canc Ctr, Dept Breast Med Oncol, 1155 Pressler St, Houston, TX 77030 USA.
    Bandera, Elisa V.
    Rutgers Canc Inst New Jersey, Canc Prevent & Control Program, 195 Little Albany St,Room 5568, New Brunswick, NJ 08903 USA.
    Barkardottir, Rosa B.
    Landspitali Univ Hosp, Dept Pathol, IS-101 Reykjavik, Iceland;Univ Iceland, Fac Med, BMC Biomed Ctr, Vatnsmyrarvegi 16, IS-101 Reykjavik, Iceland.
    Barnes, Daniel R.
    Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, 2 Worts Causeway, Cambridge CB1 8RN, England.
    Batra, Jyotsna
    Australian Prostate Canc Res Ctr Qld, Translat Res Inst, 37 Kent St, Woolloongabba, Qld 4102, Australia;Queensland Univ Technol, Inst Hlth & Biomed Innovat, 60 Musk Ave, Kelvin Grove, Qld 4059, Australia;Queensland Univ Technol, Sch Biomed Sci, 60 Musk Ave, Kelvin Grove, Qld 4059, Australia.
    Beckmann, Matthias W.
    Friedrich Alexander Univ Erlangen Nuremberg, Univ Hosp Erlangen, Comprehens Canc Ctr Erlangen Nuremberg, Dept Gynecol & Obstet, Univ Str 21-23, D-91054 Erlangen, Germany.
    Benitez, Javier
    Spanish Natl Canc Res Ctr CNIO, Human Canc Genet Programme, Calle Melchor Fernandez Almagro 3, Madrid 28029, Spain;Biomed Network Rare Dis CIBERER, AvMonforte Lemos,3-5Pabellon 11Planta 0, Madrid 28029, Spain.
    Benlloch, Sara
    Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, 2 Worts Causeway, Cambridge CB1 8RN, England;Inst Canc Res, Div Genet & Epidemiol, 15 Cotswold Rd, Sutton SM2 5NG, Surrey, England.
    Berchuck, Andrew
    Duke Univ, Dept Obstet & Gynecol, Med Ctr, 25171 Morris Bldg, Durham, NC 27710 USA.
    Berndt, Sonja I.
    NCI, Div Canc Epidemiol & Genet, 9609 Med Ctr Dr, Rockville, MD 20850 USA.
    Bickeboeller, Heike
    Univ Med Ctr Goettingen, Dept Genet Epidemiol, Humboldtallee 32, D-37073 Gottingen, Germany.
    Bien, Stephanie A.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1100 Fairview Ave N, Seattle, WA 98109 USA;Univ Washington, Sch Publ Hlth, 1959 NE Pacific St,Hlth Sci Bldg,F-350, Seattle, WA 98195 USA.
    Blomqvist, Carl
    Univ Helsinki, Helsinki Univ Hosp, Dept Oncol, Haartmaninkatu 4, FIN-00290 Helsinki, Finland;Orebro Univ Hosp, Dept Oncol, S-70185 Orebro, Sweden.
    Boccia, Stefania
    Fdn Policlin Univ AGemelli IRCCS, I-00168 Rome, Italy;Univ Cattolica Sacro Cuore, I-00168 Rome, Italy.
    Bogdanova, Natalia V.
    NNAlexandrov Res Inst Oncol & Med Radiol, Settlement Lesnoy 2, Minsk 223040, BELARUS;Hannover Med Sch, Dept Radiat Oncol, Carl Neuberg Str 1, D-30625 Hannover, Germany;Hannover Med Sch, Gynaecol Res Unit, Carl Neuberg Str 1, D-30625 Hannover, Germany.
    Bojesen, Stig E.
    Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Copenhagen Gen Populat Study, Herlev Ringvej 75, DK-75 Herlev, Denmark;Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Dept Clin Biochem, Herlev Ringvej 75, DK-75 Herlev, Denmark;Univ Copenhagen, Fac Hlth & Med Sci, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.
    Bolla, Manjeet K.
    Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, 2 Worts Causeway, Cambridge CB1 8RN, England.
    Brauch, Hiltrud
    DrMargarete Fischer Bosch Inst Clin Pharmacol, Auerbachstr112, D-70376 Stuttgart, Germany;Univ Tubingen, Geschwister Scholl Pl, D-72074 Tubingen, Germany;German Canc Res Ctr, German Canc Consortium DKTK, Neuenheimer Feld 280, D-69120 Heidelberg, Germany.
    Brenner, Hermann
    German Canc Res Ctr, German Canc Consortium DKTK, Neuenheimer Feld 280, D-69120 Heidelberg, Germany;German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Neuenheimer Feld 280, D-69120 Heidelberg, Germany;German Canc Res Ctr, Div Prevent Oncol, Neuenheimer Feld 280, D-69120 Heidelberg, Germany;Natl Ctr Tumor Dis NCT, Neuenheimer Feld 280, D-69120 Heidelberg, Germany.
    Brenton, James D.
    Univ Cambridge, Canc Res UK Cambridge Inst, Li Ka Shing Ctr, Robinson Way, Cambridge CB2 0RE, England.
    Brook, Mark N.
    Inst Canc Res, Div Genet & Epidemiol, 15 Cotswold Rd, Sutton SM2 5NG, Surrey, England.
    Brunet, Joan
    CIBERONC, Catalan Inst Oncol, IDIBGI Inst Invest Biomed Girona, Genet Counseling Unit,Hereditary Canc Program, AvFranca S-N, Girona 17007, Spain.
    Brunnstrom, Hans
    Lund Univ, Clin Sci, Box 117, S-22100 Lund, Sweden;Dept Genet & Pathol, Div Lab Med, S-22185 Lund, Sweden.
    Buchanan, Daniel D.
    Univ Melbourne, Victorian Comprehens Canc Ctr, Ctr Canc Res, Parkville, Vic 3010, Australia;Univ Melbourne, Dept Clin Pathol, Colorectal Oncogen Grp, Parkville, Vic 3010, Australia;Royal Melbourne Hosp, Genom Med & Family Canc Clin, Parkville, Vic 3010, Australia.
    Burwinkel, Barbara
    Heidelberg Univ, Dept Obstet & Gynecol, Neuenheimer Feld 440, D-69120 Heidelberg, Germany;German Canc Res Ctr, Mol Epidemiol Grp, C080,Neuenheimer Feld 280, D-69120 Heidelberg, Germany.
    Butzow, Ralf
    Univ Helsinki, Dept Pathol, Biomed Helsinki 4th Floor,Haartmaninkatu 8, Helsinki 00029, Finland;Helsinki Univ Hosp, Biomed Helsinki 4th Floor,Haartmaninkatu 8, Helsinki 00029, Finland.
    Cadoni, Gabriella
    Fdn Policlin Univ AGemelli IRCCS, I-00168 Rome, Italy;Univ Cattolica Sacro Cuore, I-00168 Rome, Italy.
    Caldes, Trinidad
    Hosp Clin San Carlos, Inst Invest Sanitaria San Carlos IdISSC, Med Oncol Dept, Ctr Invest Biomed Red Canc CIBERONC, Calle Prof Martin Lagos, Madrid 28040, Spain.
    Caligo, Maria A.
    Univ Pisa, Dept Lab Med, Sect Genet Oncol, Via Roma 67, I-56126 Pisa, Italy;Univ Hosp Pisa, Via Roma 67, I-56126 Pisa, Italy.
    Campbell, Ian
    Peter MacCallum Canc Ctr, 305 Grattan St, Melbourne, Vic 3000, Australia;Univ Melbourne, Sir Peter MacCallum Dept Oncol, 305 Grattan St, Melbourne, Vic 3000, Australia.
    Campbell, Peter T.
    Amer Canc Soc, Epidemiol Res Program, 250 Williams St NW, Atlanta, GA 30303 USA.
    Cancel-Tassin, Geraldine
    Sorbonne Univ, Tenon Hosp, GRC N 5 ONCOTYPE URO, F-75020 Paris, France;Tenon Hosp, CeRePP, F-75020 Paris, France.
    Cannon-Albright, Lisa
    Univ Utah, Dept Med, Div Genet Epidemiol, Sch Med, Salt Lake City, UT 84112 USA;George EWahlen Dept Vet Affairs Med Ctr, Salt Lake City, UT 84112 USA.
    Campa, Daniele
    German Canc Res Ctr, Div Canc Epidemiol, Neuenheimer Feld 280, D-69120 Heidelberg, Germany;Univ Pisa, Dept Biol, I-56126 Pisa, Italy.
    Caporaso, Neil
    NCI, Div Canc Epidemiol & Genet, 9609 Med Ctr Dr, Rockville, MD 20850 USA.
    Carvalho, Andre L.
    Barretos Canc Hosp, Mol Oncol Res Ctr, Rua Antenor Duarte Villela 1331, BR-784400 Barretos, SP, Brazil;Barretos Canc Hosp, Head & Neck Surg Dept, Pio 12,1331 Antenor Duarte Villela St, BR-14784400 Barretos, SP, Brazil.
    Chan, Andrew T.
    Massachusetts Gen Hosp, Div Gastroenterol, 55 Fruit St, Boston, MA 02114 USA;Harvard Med Sch, Brigham & Womens Hosp, Channing Div Network Med, Dept Med, 181 Longwood Ave, Boston, MA 02115 USA.
    Chang-Claude, Jenny
    German Canc Res Ctr, Div Canc Epidemiol, Neuenheimer Feld 280, D-69120 Heidelberg, Germany;Univ Med Ctr Hamburg Eppendorf, UCCH, Canc Epidemiol Grp, Martinistr 52, D-20246 Hamburg, Germany.
    Chanock, Stephen J.
    NCI, Div Canc Epidemiol & Genet, 9609 Med Ctr Dr, Rockville, MD 20850 USA.
    Chen, Chu
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Program Epidemiol, 1100 Fairview Ave N, Seattle, WA 98109 USA.
    Christiani, David C.
    Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, 677 Huntington Ave, Boston, MA 02115 USA.
    Claes, Kathleen B. M.
    Univ Ghent, Ctr Med Genet, De Pintelaan 185, B-9000 Ghent, Belgium.
    Claessens, Frank
    Katholieke Univ Leuven, Dept Cellular & Mol Med, Mol Endocrinol Lab, B-3000 Leuven, Belgium.
    Clements, Judith
    Australian Prostate Canc Res Ctr Qld, Translat Res Inst, 37 Kent St, Woolloongabba, Qld 4102, Australia;Queensland Univ Technol, Inst Hlth & Biomed Innovat, 60 Musk Ave, Kelvin Grove, Qld 4059, Australia;Queensland Univ Technol, Sch Biomed Sci, 60 Musk Ave, Kelvin Grove, Qld 4059, Australia.
    Collee, J. Margriet
    Erasmus MC, Dept Clin Genet, Wytemaweg 80, NL-3015 CN Rotterdam, Netherlands.
    Correa, Marcia Cruz
    Univ Puerto Rico Med Sci Campus, San Juan, PR 00936 USA;Comprehens Canc Ctr, San Juan, PR 00936 USA.
    Couch, Fergus J.
    Mayo Clin, Dept Lab Med & Pathol, 200 First StSW, Rochester, MN 55905 USA.
    Cox, Angela
    Univ Sheffield, Sheffield Inst Nucle Acids SInFoNiA, Dept Oncol & Metab, Western Bank, Sheffield S10 2TN, S Yorkshire, England.
    Cunningham, Julie M.
    Mayo Clin, Dept Lab Med & Pathol, 200 First StSW, Rochester, MN 55905 USA.
    Cybulski, Cezary
    Pomeranian Med Univ, Dept Genet & Pathol, Int Hereditary Canc Ctr, ulUnii Lubelskiej 1, PL-71252 Szczecin, Poland.
    Czene, Kamila
    Karolinska Inst, Karolinska Univ Hosp, Dept Med Epidemiol & Biostat, S-17176 Stockholm, Sweden.
    Daly, Mary B.
    Fox Chase Canc Ctr, Dept Clin Genet, 333 Cottman Ave, Philadelphia, PA 19111 USA.
    defazio, Anna
    Univ Sydney, Westmead Inst Med Res, Ctr Canc Res, 176 Hawkesbury Rd, Sydney, NSW 2145, Australia;Westmead Hosp, Dept Gynaecol Oncol, Hawkesbury Rd & Darcy Rd, Sydney, NSW 2145, Australia.
    Devilee, Peter
    Leiden Univ Med Ctr, Dept Pathol, Albinusdreef 2, NL-2333 ZA Leiden, Netherlands;Leiden Univ Med Ctr, Dept Human Genet, Albinusdreef 2, NL-2333 ZA Leiden, Netherlands.
    Diez, Orland
    Univ Hosp Vall dHebron, Vall dHebron Inst Oncol VHIO, Clin & Mol Genet Area, Oncogenet Grp, Passeig Vall dHebron 119-129, Barcelona 08035, Spain.
    Gago-Dominguez, Manuela
    Complejo Hosp Univ Santiago, SERGAS, Inst Invest Sanitaria Santiago de Compostela IDIS, Genom Med Grp,Galician Fdn Genom Med, Travesia Choupana S-N, Santiago De Compostela 15706, Spain;Univ Calif San Diego, Moores Canc Ctr, 3855 Hlth Sci Dr, La Jolla, CA 92037 USA.
    Donovan, Jenny L.
    Univ Bristol, Sch Social & Community Med, Bristol BS8 1TH, Avon, England.
    Doerk, Thilo
    Duell, Eric J.
    ICO IDIBELL, Canc Epidemiol Res Program, Unit Nutr & Canc, AvGran Via 199-203, Barcelona 08908, Spain.
    Dunning, Alison M.
    Univ Cambridge, Dept Oncol, Ctr Canc Genet Epidemiol, 2 Worts Causeway, Cambridge CB1 8RN, England.
    Dwek, Miriam
    Univ Westminster, Fac Sci & Technol, Dept Biomed Sci, 309 Regent St, London W1B 2HW, England.
    Eccles, Diana M.
    Univ Southampton, Canc Sci Acad Unit, Fac Med, Tremona Rd, Southampton SO16 6YD, Hants, England.
    Edlund, Christopher K.
    Univ Southern Calif, Keck Sch Med, Dept Med, Los Angeles, CA 90033 USA.
    Edwards, Digna R. Velez
    Vanderbilt Univ, Med Ctr, Dept Obstet & Gynecol, Vanderbilt Epidemiol Ctr,Vanderbilt Genet Inst, 2525 West End Ave,Suite 600, Nashville, TN 37203 USA.
    Ellberg, Carolina
    Lund Univ, Dept Canc Epidemiol, Clin Sci, Barngatan 4, S-22242 Lund, Sweden.
    Evans, D. Gareth
    Univ Manchester, Cent Manchester Univ Hosp NHS Fdn Trust, Manchester Ctr Genom Med, Div Evolut & Genom Sci,St Marys Hosp, Oxford Rd, Manchester M13 9WL, Lancs, England.
    Fasching, Peter A.
    Friedrich Alexander Univ Erlangen Nuremberg, Univ Hosp Erlangen, Comprehens Canc Ctr Erlangen Nuremberg, Dept Gynecol & Obstet, Univ Str 21-23, D-91054 Erlangen, Germany;Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Div Hematol & Oncol, 10833 Le Conte Ave, Los Angeles, CA 90095 USA.
    Ferris, Robert L.
    Univ Pittsburgh, UPMC Hillman Canc Ctr, Dept Otolaryngol, Canc Pavil,Suite 500,5150 Ctr Ave, Pittsburgh, PA 15232 USA.
    Liloglou, Triantafillos
    Univ Liverpool, Mol & Clin Canc Med, Roy Castle Lung Canc Res Programme, Inst Translat Med, Wiliam Duncan Bldg,6 West Derby St, Liverpool L69 3BX, Merseyside, England.
    Figueiredo, Jane C.
    Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, 8700 Beverly Blvd, Los Angeles, CA 90048 USA;Univ Southern Calif, Keck Sch Med, 1450 Biggy St, Los Angeles, CA 90033 USA.
    Fletcher, Olivia
    Int Agcy Res Canc, Genet Epidemiol Grp, 150 Cours Albert Thomas, F-69008 Lyon, France;Inst Canc Res, Breast Canc Now Toby Robins Res Ctr, 123 Old Brompton Rd, London SW7 3RP, England.
    Fortner, Renee T.
    German Canc Res Ctr, Div Canc Epidemiol, Neuenheimer Feld 280, D-69120 Heidelberg, Germany.
    Fostira, Florentia
    Natl Ctr Sci Res Demokritos, Mol Diagnost Lab, INRASTES, Neapoleos 10, Athens 15310, Greece.
    Franceschi, Silvia
    Int Agcy Res Canc, Sect Infect, 150 Cours Albert Thomas, F-69008 Lyon, France.
    Friedman, Eitan
    Chaim Sheba Med Ctr, Susanne Levy Gertner Oncogenet Unit, Emek HaEla St 1, IL-52621 Ramat Gan, Israel;Tel Aviv Univ, Sackler Fac Med, Haim Levanon 30, IL-69978 Ramat Aviv, Israel.
    Gallinger, Steven J.
    Mt Sinai Hosp, Dept Surg, 600 Univ Ave, Toronto, ON M5G 1X5, Canada;Samuel Lunenfeld Res Inst, 600 Univ Ave, Toronto, ON M5G 1X5, Canada;Univ Hlth Network Toronto Gen Hosp, 200 Elizabeth St, Toronto, ON M5G 2C4, Canada.
    Ganz, Patricia A.
    Univ Calif Los Angeles, Jonsson Comprehens Canc Ctr, Div Canc Prevent & Control Res, Sch Med, 650 Charles Young Dr South, Los Angeles, CA 90095 USA;Univ Calif Los Angeles, Jonsson Comprehens Canc Ctr, Div Canc Prevent & Control Res, Sch Publ Hlth, 650 Charles Young Dr South, Los Angeles, CA 90095 USA.
    Garber, Judy
    Dana Farber Canc Inst, Canc Risk & Prevent Clin, 450 Brookline Ave, Boston, MA 02215 USA.
    Garcia-Saenz, Jose A.
    Hosp Clin San Carlos, Inst Invest Sanitaria San Carlos IdISSC, Med Oncol Dept, Ctr Invest Biomed Red Canc CIBERONC, Calle Prof Martin Lagos, Madrid 28040, Spain.
    Gayther, Simon A.
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, 1975 Zonal Ave, Los Angeles, CA 90033 USA;Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, Ctr Canc Prevent & Translat Genom, Spielberg Bldg,8725 Alden Dr, Los Angeles, CA 90048 USA;Cedars Sinai Med Ctr, Dept Biomed Sci, Spielberg Bldg,8725 Alden Dr, Los Angeles, CA 90048 USA.
    Giles, Graham G.
    Canc Council Victoria, Canc Epidemiol & Intelligence Div, 615 St Kilda Rd, Melbourne, Vic 3004, Australia;Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Level 1,723 Swanston St, Melbourne, Vic 3010, Australia;Monash Univ, Dept Epidemiol & Prevent Med, Melbourne, Vic, Australia.
    Godwin, Andrew K.
    Univ Kansas, Dept Pathol & Lab Med, Med Ctr, 3901 Rainbow Blvd, Kansas City, KS 66160 USA.
    Goldberg, Mark S.
    Int Agcy Res Canc, Genet Epidemiol Grp, 150 Cours Albert Thomas, F-69008 Lyon, France;McGill Univ, Dept Med, 1001 Decarie Blvd, Montreal, PQ H4A 3J1, Canada;McGill Univ, Royal Victoria Hosp, Div Clin Epidemiol, 1001 Decarie Blvd, Montreal, PQ H4A 3J1, Canada.
    Goldgar, David E.
    Int Agcy Res Canc, Genet Epidemiol Grp, 150 Cours Albert Thomas, F-69008 Lyon, France;Univ Utah, Huntsman Canc Inst, Dept Dermatol, Sch Med, 2000 Circle Hope, Salt Lake City, UT 84112 USA.
    Goode, Ellen L.
    Int Agcy Res Canc, Genet Epidemiol Grp, 150 Cours Albert Thomas, F-69008 Lyon, France;Mayo Clin, Dept Hlth Sci Res, 200 First StSW, Rochester, MN 55905 USA.
    Goodman, Marc T.
    Int Agcy Res Canc, Genet Epidemiol Grp, 150 Cours Albert Thomas, F-69008 Lyon, France;Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, Canc Prevent & Control, 8700 Beverly Blvd,Room 1S37, Los Angeles, CA 90048 USA;Cedars Sinai Med Ctr, Dept Biomed Sci, Commun & Populat Hlth Res Inst, 8700 Beverly Blvd,Room 1S37, Los Angeles, CA 90048 USA.
    Goodman, Gary
    Int Agcy Res Canc, Genet Epidemiol Grp, 150 Cours Albert Thomas, F-69008 Lyon, France;Swedish Canc Inst, Div Publ Hlth Sci, 1221 Madison StSte 300, Seattle, WA 98109 USA.
    Grankvist, Kjell
    Int Agcy Res Canc, Genet Epidemiol Grp, 150 Cours Albert Thomas, F-69008 Lyon, France;Umea Univ, Unit Clin Chem, Dept Med Biosci, 6M Van 2, S-90185 Umea, Sweden.
    Greene, Mark H.
    Int Agcy Res Canc, Genet Epidemiol Grp, 150 Cours Albert Thomas, F-69008 Lyon, France;NCI, Clin Genet Branch, DCEG, 9609 Med Ctr Dr, Bethesda, MD 20850 USA.
    Gronberg, Henrik
    Karolinska Inst, Karolinska Univ Hosp, Dept Med Epidemiol & Biostat, S-17176 Stockholm, Sweden.
    Gronwald, Jacek
    Pomeranian Med Univ, Dept Genet & Pathol, Int Hereditary Canc Ctr, ulUnii Lubelskiej 1, PL-71252 Szczecin, Poland.
    Guenel, Pascal
    Int Agcy Res Canc, Genet Epidemiol Grp, 150 Cours Albert Thomas, F-69008 Lyon, France;Univ Paris Saclay, Univ Paris Sud, Ctr Res Epidemiol & Populat Hlth CESP, Canc & Environm Grp,INSERM, F-94805 Villejuif, France.
    Hakansson, Niclas
    Karolinska Inst, Div Nutr Epidemiol, Dept Environm Med, Nobels Vag 13, S-17177 Stockholm, Sweden.
    Hall, Per
    Karolinska Inst, Karolinska Univ Hosp, Dept Med Epidemiol & Biostat, S-17176 Stockholm, Sweden;Soder Sjukhuset, Dept Oncol, Sjukhusbacken 10, S-11883 Stockholm, Sweden.
    Hamann, Ute
    German Canc Res Ctr, Mol Genet Breast Canc, Neuenheimer Feld 580, D-69120 Heidelberg, Germany.
    Hamdy, Freddie C.
    Univ Oxford, John Radcliffe Hosp, Nuffield Dept Surg Sci, Fac Med Sci, Oxford OX1 2JD, England.
    Hamilton, Robert J.
    Princess Margaret Canc Ctr, Dept Surg Oncol, 610 Univ Ave, Toronto, ON M5G 2M9, Canada.
    Hampe, Jochen
    Tech Univ Dresden, Univ Hosp Dresden, Dept Internal Med 1, D-01307 Dresden, Germany.
    Haugen, Aage
    German Canc Res Ctr, Div Canc Epidemiol, Neuenheimer Feld 280, D-69120 Heidelberg, Germany;Natl Inst Occupat Hlth STAMI, Gydas Vei 8, N-0033 Oslo, Norway.
    Heitz, Florian
    DrHorst Schmidt Kliniken Wiesbaden, Dept Gynecol & Gynecol Oncol, Ludwig Erhard Str 100, D-65199 Wiesbaden, Germany;Knappschaft GmbH, Dept Gynecol & Gynecol Oncol, Kliniken Essen Mitte, EvangHuyssens Stiftung, Henricistr 92, D-45136 Essen, Germany.
    Herrero, Rolando
    Int Agcy Res Canc, Early Detect & Prevent Sect, 150 Cours Albert Thomas, F-69008 Lyon, France.
    Hillemanns, Peter
    Hoffmeister, Michael
    German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Neuenheimer Feld 280, D-69120 Heidelberg, Germany.
    Hogdall, Estrid
    Danish Canc Soc Res Ctr, Dept Virus Lifestyle & Genes, Strandboulevarden 49, DK-2100 Copenhagen, Denmark;Univ Copenhagen, Herlev Hosp, Dept Pathol, Mol Unit, Herlev Ringvej 75, DK-75 Herlev, Denmark.
    Hong, Yun-Chul
    Seoul Natl Univ, Coll Med, Prevent Med, 1 Gwanak Ro, Seoul 151742, South Korea.
    Hopper, John L.
    Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Level 1,723 Swanston St, Melbourne, Vic 3010, Australia.
    Houlston, Richard
    Inst Canc Res, German Res Ctr Environm Hlth, Ingolstadter Landstr1, Sutton SM2 5NG, Surrey, England.
    Hulick, Peter J.
    NorthShore Univ HealthSystem, Ctr Med Genet, Evanston, IL 1000 USA;Univ Chicago, Pritzker Sch Med, 924 E 57th St, Chicago, IL 60637 USA.
    Hunter, David J.
    Harvard TH Chan Sch Publ Hlth, Program Genet Epidemiol & Stat Genet, 677 Huntington Ave, Boston, MA 02115 USA.
    Huntsman, David G.
    BC Canc Agcy, Vancouver Gen Hosp, British Columbias Ovarian Canc Res OVCARE Program, 3427-600 West 10th Ave, Vancouver, BC V5Z 4E6, Canada;Univ British Columbia, 3427-600 West 10th Ave, Vancouver, BC V5Z 4E6, Canada;BC Canc Agcy Res Ctr, Dept Mol Oncol, 3427-600 West 10th Ave, Vancouver, BC V5Z 4E6, Canada.
    Idos, Gregory
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Norris Comprehens Canc Ctr, Los Angeles, CA 48109 USA.
    Imyanitov, Evgeny N.
    Univ British Columbia, Dept Pathol & Lab Med, 3427-600 West 10th Ave, Vancouver, BC V5Z 4E6, Canada;NNPetrov Inst Oncol, Leningradskaya Ul 68, St Petersburg 197758, Russia.
    Ingles, Sue Ann
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Norris Comprehens Canc Ctr, Los Angeles, CA 48109 USA.
    Isaacs, Claudine
    Georgetown Univ, Lombardi Comprehens Canc Ctr, 3800 Reservoir Rd, Washington, DC 20007 USA.
    Jakubowska, Anna
    Pomeranian Med Univ, Dept Genet & Pathol, Int Hereditary Canc Ctr, ulUnii Lubelskiej 1, PL-71252 Szczecin, Poland;Pomeranian Med Univ, Independent Lab Mol Biol & Genet Diagnost, Rybacka 1, PL-70204 Szczecin, Poland.
    James, Paul
    Univ Melbourne, Sir Peter MacCallum Dept Oncol, 305 Grattan St, Melbourne, Vic 3000, Australia;Peter MacCallum Canc Ctr, Parkville Familial Canc Ctr, 305 Grattan St, Melbourne, Vic 3000, Australia.
    Jenkins, Mark A.
    Univ Melbourne, Victorian Comprehens Canc Ctr, Ctr Canc Res, Parkville, Vic 3010, Australia;Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Level 1,723 Swanston St, Melbourne, Vic 3010, Australia.
    Johansson, Mattias
    Int Agcy Res Canc, Sect Genet, 150 Cours Albert Thomas, F-69008 Lyon, France.
    Johansson, Mikael
    Umea Univ, Dept Radiat Sci, 6M Van 2, S-90185 Umea, Sweden.
    John, Esther M.
    Stanford Univ, Sch Med, Div Oncol, Dept Med, 780 Welch Rd, Stanford, CA 94304 USA;Stanford Univ, Sch Med, Stanford Canc Inst, 780 Welch Rd, Stanford, CA 94304 USA.
    Joshi, Amit D.
    Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, 677 Huntington Ave, Boston, MA 02115 USA;Massachusetts Gen Hosp, Clin & Translat Epidemiol Unit, Boston, MA 02114 USA.
    Kaneva, Radka
    Med Univ Sofia, Fac Med, Dept Med Chem & Biochem, Mol Med Ctr, Sofia 1504, Bulgaria.
    Karlan, Beth Y.
    Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, Womens Canc Program, 8700 Beverly Blvd, Los Angeles, CA 90048 USA.
    Kelemen, Linda E.
    Med Univ South Carolina, Hollings Canc Ctr, 68 President St Bioengineering Bldg,MSC955, Charleston, SC 29425 USA;Med Univ South Carolina, Dept Publ Hlth Sci, 68 President St Bioengineering Bldg,MSC955, Charleston, SC 29425 USA.
    Kuhl, Tabea
    Univ Med Ctr Hamburg Eppendorf, UCCH, Canc Epidemiol, Martinistr 52, D-20246 Hamburg, Germany.
    Khaw, Kay-Tee
    Univ Cambridge, Dept Publ Hlth & Primary Care, Clin Gerontol, 2 Worts Causeway, Cambridge CB1 8RN, England.
    Khusnutdinova, Elza
    Bashkir State Univ, Dept Genet & Fundamental Med, ulZaki Validi 32, Ufa 450076, Russia;Russian Acad Sci, Inst Biochem & Genet, Ufa Sci Ctr, 71 Prosp Oktyabrya, Ufa 450054, Russia.
    Kibel, Adam S.
    Brigham & Womens Hosp, Div Urol Surg, Boston, MA USA.
    Kiemeney, Lambertus A.
    Radboud Univ Nijmegen, Radboud Inst Hlth Sci, Med Ctr, Geert Grooteplein 21, NL-6525 EZ Nijmegen, Netherlands.
    Kim, Jeri
    Univ Texas MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, 1155 Pressler St, Houston, TX 77030 USA.
    Kjaer, Susanne K.
    Danish Canc Soc Res Ctr, Dept Virus Lifestyle & Genes, Strandboulevarden 49, DK-2100 Copenhagen, Denmark;Univ Copenhagen, Dept Gynaecol, Rigshosp, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.
    Knight, Julia A.
    Sinai Hlth Syst, Lunenfeld Tanenbaum Res Inst, Prosserman Ctr Populat Hlth Res, 60 Murray St, Toronto, ON M5T 3L9, Canada;Univ Toronto, Dalla Lana Sch Publ Hlth, Div Epidemiol, 155 Coll St, Toronto, ON M5T 3M7, Canada.
    Kogevinas, Manolis
    Biomed Network Rare Dis CIBERER, AvMonforte Lemos,3-5Pabellon 11Planta 0, Madrid 28029, Spain;ISGlobal, Ctr Res Environm Epidemiol CREAL, Barcelona 08036, Spain;IMIM Hosp del Mar Res Inst, Barcelona 08003, Spain;UPF, Barcelona 08002, Spain.
    Kote-Jarai, Zsofia
    Inst Canc Res, Div Genet & Epidemiol, 15 Cotswold Rd, Sutton SM2 5NG, Surrey, England.
    Koutros, Stella
    NCI, Div Canc Epidemiol & Genet, Dept Hlth & Human Serv, NIH, 9609 Med Ctr Dr, Bethesda, MD 20892 USA.
    Kristensen, Vessela N.
    Oslo Univ Hosp, Inst Canc Res, Dept Canc Genet, Radiumhosp, Ullernchausseen 70, N-0379 Oslo, Norway;Univ Oslo, Fac Med, Inst Clin Med, Kirkeveien 166, N-0450 Oslo, Norway;Univ Oslo, Oslo Univ Hosp, Dept Clin Mol Biol, Kirkeveien 166, N-0450 Oslo, Norway.
    Kupryjanczyk, Jolanta
    Maria Sklodowska Curie Inst, Ctr Oncol, Dept Pathol & Lab Diagnost, Roentgena 5, PL-02781 Warsaw, Poland.
    Lacko, Martin
    Maastricht Univ, Med Ctr, Dept Otorhinolaryngol, Head & Neck Surg, PDebyelaan 25,POBox 5800, NL-6202 AZ Maastricht, Netherlands.
    Lam, Stephan
    British Columbia Canc Agcy, Dept Integrat Oncol, Room 10-111 675 West 10th Ave, Vancouver, BC V5Z 1L3, Canada.
    Lambrechts, Diether
    VIB, VIB Ctr Canc Biol, Herestr 49, B-3001 Leuven, Belgium;Univ Leuven, Dept Human Genet, Lab Translat Genet, Oude Markt 13, B-3000 Leuven, Belgium.
    Landi, Maria Teresa
    NCI, Integrat Tumor Epidemiol Branch, DCEG, 9609 Med Ctr Dr,Room SG 7E106, Rockville, MD 20850 USA.
    Lazarus, Philip
    Washington State Univ, Coll Pharm, PBS 431 POB 1495, Spokane, WA 99210 USA.
    Le, Nhu D.
    BC Canc Agcy, Canc Control Res, 675 West 10th Ave, Vancouver, BC V5Z 1L3, Canada.
    Lee, Eunjung
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, 1975 Zonal Ave, Los Angeles, CA 90033 USA.
    Lejbkowicz, Flavio
    Carmel Hosp, Clalit Natl Israeli Canc Control Ctr, Clalit Hlth Serv, 2 Horev St, IL-3436212 Haifa, Israel.
    Lenz, Heinz-Josef
    Univ Southern Calif, Keck Sch Med, Dept Med, Los Angeles, CA 90033 USA.
    Leslie, Goska
    Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, 2 Worts Causeway, Cambridge CB1 8RN, England.
    Lessel, Davor
    Univ Med Ctr Hamburg Eppendorf, Inst Human Genet, Martinistr 52, D-20246 Hamburg, Germany.
    Lester, Jenny
    Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, Womens Canc Program, 8700 Beverly Blvd, Los Angeles, CA 90048 USA.
    Levine, Douglas A.
    Mem Sloan Kettering Canc Ctr, Dept Surg, Gynecol Serv, 1275 York Ave, New York, NY 10065 USA;NYU Langone Med Ctr, Laura & Isaac Pearlmutter Canc Ctr, Gynecol Oncol, 240 East 38th St 19th Floor, New York, NY 10016 USA.
    Li, Li
    Case Western Reserve Univ, Mary Ann Swetland Ctr Environm Hlth, Dept Family Med & Community Hlth, Cleveland, OH 44106 USA;Inst Invest Sanitaria Santiago de Compostela IDIS, Serv Galego Saude SERGAS, Santiago De Compostela 15706, Spain.
    Li, Christopher I.
    Fred Hutchinson Canc Res Ctr, Translat Res Program, Seattle, WA 98109 USA.
    Lindblom, Annika
    Karolinska Inst, Karolinska Univ Hosp, Dept Mol Med & Surg, S-17176 Stockholm, Sweden.
    Lindor, Noralane M.
    Mayo Clin Arizona, Hlth Sci Res, 13400 EShea Blvd, Scottsdale, AZ 85259 USA.
    Liu, Geoffrey
    Princess Margaret Canc Ctr, Div Epidemiol, 610 Univ Ave, Toronto, ON M5G 2M9, Canada.
    Loupakis, Fotios
    Ist Oncol Veneto IRCCS, Dept Clin & Expt Oncol, Unit Oncol 1, I-35122 Padua, Italy.
    Lubinski, Jan
    Pomeranian Med Univ, Dept Genet & Pathol, Int Hereditary Canc Ctr, ulUnii Lubelskiej 1, PL-71252 Szczecin, Poland.
    Maehle, Lovise
    Oslo Univ Hosp, Dept Med Genet, Kirkeveien 166, N-0450 Oslo, Norway.
    Maier, Christiane
    Univ Hosp Ulm, Inst Human Genet, Prittwitzstr 43, D-89075 Ulm, Germany.
    Mannermaa, Arto
    Univ Eastern Finland, Translat Canc Res Area, Yliopistonranta 1, Kuopio 70210, Finland;Univ Eastern Finland, Inst Clin Med Pathol & Forens Med, KuopioYliopistonranta 1, Kuopio 70210, Finland;Kuopio Univ Hosp, Dept Clin Pathol, Imaging Ctr, Puijonlaaksontie 2, Kuopio 70210, Finland.
    Le Marchand, Loic
    Univ Hawaii, Program Epidemiol, Ctr Canc, 701 Ilalo St, Honolulu, HI 96813 USA.
    Margolin, Sara
    Karolinska Inst, Dept Clin Sci & Educ, Sodersjukhuset, S-17177 Stockholm, Sweden.
    May, Taymaa
    Univ Hlth Network, Div Gynecol Oncol, Princess Margaret Hosp, 610 Univ Ave,OPG Wing 6-811, Toronto, ON M5G 2M9, Canada.
    McGuffog, Lesley
    Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, 2 Worts Causeway, Cambridge CB1 8RN, England.
    Meindl, Alfons
    Int Agcy Res Canc, Genet Epidemiol Grp, 150 Cours Albert Thomas, F-69008 Lyon, France;Tech Univ Munich, Div Gynaecol & Obstet, Arcisstr 21, D-80333 Munich, Germany.
    Middha, Pooja
    German Canc Res Ctr, Div Canc Epidemiol, Neuenheimer Feld 280, D-69120 Heidelberg, Germany;Heidelberg Univ, Fac Med, Neuenheimer Feld 672, D-69120 Heidelberg, Germany.
    Miller, Austin
    Roswell Pk Canc Inst, Stat & Data Management Ctr, NRG Oncol, Elm & Carlton St, Buffalo, NY 14263 USA.
    Milne, Roger L.
    Canc Council Victoria, Canc Epidemiol & Intelligence Div, 615 St Kilda Rd, Melbourne, Vic 3004, Australia;Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Level 1,723 Swanston St, Melbourne, Vic 3010, Australia.
    MacInnis, Robert J.
    Canc Council Victoria, Canc Epidemiol & Intelligence Div, 615 St Kilda Rd, Melbourne, Vic 3004, Australia;Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Level 1,723 Swanston St, Melbourne, Vic 3010, Australia.
    Modugno, Francesmary
    Magee Womens Res Inst, Canc Res Ctr, Pittsburgh, PA 15213 USA;Hillman Canc Ctr, Pittsburgh, PA 15213 USA;Univ Pittsburgh, Sch Med, Dept Obstet Gynecol & Reprod Sci, Div Gynecol Oncol, 300 Halket St, Pittsburgh, PA 15213 USA.
    Montagna, Marco
    Veneto Inst Oncol IOV IRCCS, Immunol & Mol Oncol Unit, Via Gattamelata 64, I-35128 Padua, Italy.
    Moreno, Victor
    Consortium Biomed Res Epidemiol & Publ Hlth CIBER, Bellvitge Biomed Res Inst IDIBELL, Catalan Inst Oncol, Barcelona 08908, Spain;Univ Barcelona, Barcelona 08908, Spain.
    Moysich, Kirsten B.
    Roswell Pk Canc Inst, Div Canc Prevent & Control, Elm & Carlton St, Buffalo, NY 14263 USA.
    Mucci, Lorelei
    Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, 677 Huntington Ave, Boston, MA 02115 USA.
    Muir, Kenneth
    Univ Manchester, Div Populat Hlth Hlth Serv Res & Primary Care, Oxford Rd, Manchester M13 9PL, Lancs, England;Univ Warwick, Warwick Med Sch, Div Hlth Sci, Coventry CV4 7AL, W Midlands, England.
    Mulligan, Anna Marie
    Univ Toronto, Dept Lab Med & Pathobiol, 1 Kings Coll Circle, Toronto, ON M5S 1A8, Canada;Univ Hlth Network, Lab Med Program, 200 Elizabeth St, Toronto, ON M5G 2C4, Canada.
    Nathanson, Katherine L.
    Univ Penn, Perelman Sch Med, Abramson Canc Ctr, Dept Med, 3400 Civ Ctr Blvd, Philadelphia, PA 19104 USA.
    Neal, David E.
    Univ Cambridge, Canc Res UK Cambridge Inst, Li Ka Shing Ctr, Robinson Way, Cambridge CB2 0RE, England;Univ Oxford, John Radcliffe Hosp, Nuffield Dept Surg Sci, Fac Med Sci, Oxford OX1 2JD, England;Univ Cambridge, Addenbrookes Hosp, Dept Oncol, Cambridge CB1 8RN, England.
    Ness, Andrew R.
    Univ Bristol, NIHR Bristol Biomed Res Ctr Nutr Theme, Upper Maudlin St, Bristol BS2 8AE, Avon, England.
    Neuhausen, Susan L.
    Beckman Res Inst City Hope, Dept Populat Sci, 1500 E Duarte, Duarte, CA 91010 USA.
    Nevanlinna, Heli
    Univ Helsinki, Helsinki Univ Hosp, Dept Obstet & Gynecol, Haartmaninkatu 8, FIN-00290 Helsinki, Finland.
    Newcomb, Polly A.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1100 Fairview Ave N, Seattle, WA 98109 USA;Univ Washington, Sch Publ Hlth, 1959 NE Pacific St,Hlth Sci Bldg,F-350, Seattle, WA 98195 USA.
    Newcomb, Lisa F.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1100 Fairview Ave N, Seattle, WA 98109 USA;Univ Washington, Dept Urol, Seattle, WA 98195 USA.
    Nielsen, Finn Cilius
    Copenhagen Univ Hosp, Ctr Genom Med, Rigshosp, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.
    Nikitina-Zake, Liene
    Latvian Biomed Res & Study Ctr, Ratsupites Str 1, LV-1067 Riga, Latvia.
    Nordestgaard, Borge G.
    Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Copenhagen Gen Populat Study, Herlev Ringvej 75, DK-75 Herlev, Denmark;Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Dept Clin Biochem, Herlev Ringvej 75, DK-75 Herlev, Denmark;Univ Copenhagen, Fac Hlth & Med Sci, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.
    Nussbaum, Robert L.
    Univ Calif San Francisco, Canc Genet & Prevent Program, 1600 Div St, San Francisco, CA 94143 USA.
    Offit, Kenneth
    Mem Sloan Kettering Canc Ctr, Dept Canc Biol & Genet, Clin Genet Res Lab, 1275 York Ave, New York, NY 10065 USA;Mem Sloan Kettering Canc Ctr, Dept Med, Clin Genet Serv, 1275 York Ave, New York, NY 10065 USA.
    Olah, Edith
    Natl Inst Oncol, Dept Mol Genet, Rath Gyorgy u7-9, H-1122 Budapest, Hungary.
    Al Olama, Ali Amin
    Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, 2 Worts Causeway, Cambridge CB1 8RN, England;Univ Cambridge, Dept Clin Neurosci, Cambridge CB2 0QQ, England.
    Olopade, Olufunmilayo I.
    Univ Chicago, Ctr Clin Canc Genet, 5841S Maryland Ave, Chicago, IL 60637 USA.
    Olshan, Andrew F.
    Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, 135 Dauer Dr, Chapel Hill, NC 27599 USA;UNC Lineberger Comprehens Canc Ctr, 450 West Dr, Chapel Hill, NC 27599 USA.
    Olsson, Hakan
    Lund Univ, Dept Canc Epidemiol, Clin Sci, Barngatan 4, S-22242 Lund, Sweden.
    Osorio, Ana
    Spanish Natl Canc Res Ctr CNIO, Human Canc Genet Programme, Calle Melchor Fernandez Almagro 3, Madrid 28029, Spain;Biomed Network Rare Dis CIBERER, AvMonforte Lemos,3-5Pabellon 11Planta 0, Madrid 28029, Spain.
    Pandha, Hardev
    Univ Surrey, Guildford GU2 7XH, Surrey, England.
    Park, Jong Y.
    HLee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, 12902 Magnolia Dr, Tampa, FL 33612 USA.
    Pashayan, Nora
    UCL, Dept Appl Hlth Res, 1-19 Torrington Pl, London WC1E 6BT, England;Univ Cambridge, Dept Oncol, Strangeways Lab, Ctr Canc Genet Epidemiol, Cambridge CB1 8RN, England.
    Parsons, Michael T.
    QIMR Berghofer Med Res Inst, Dept Genet & Computat Biol, 300 Herston Rd, Brisbane, Qld 4006, Australia.
    Pejovic, Tanja
    Oregon Hlth & Sci Univ, Dept Obstet & Gynecol, 3181 SW Sam Jackson Pk Rd,L-466, Portland, OR 97239 USA;Oregon Hlth & Sci Univ, Knight Canc Inst, 3181 SW Sam Jackson Pk Rd,L-466, Portland, OR 97239 USA.
    Penney, Kathryn L.
    Harvard Med Sch, Brigham & Womens Hosp, Channing Div Network Med, Dept Med, 181 Longwood Ave, Boston, MA 02115 USA.
    Peters, Wilbert H. M.
    Radboud Univ Nijmegen, Med Ctr, Dept Gastroenterol, Geert Grooteplein Zuid 10,Internal BOBox 433, NL-6525 GA Nijmegen, Netherlands.
    Phelan, Catherine M.
    HLee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, 12902 Magnolia Dr, Tampa, FL 33612 USA.
    Phipps, Amanda I.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1100 Fairview Ave N, Seattle, WA 98109 USA;Univ Washington, Sch Publ Hlth, Dept Epidemiol, 1959 NE Pacific St, Seattle, WA 98195 USA.
    Plaseska-Karanfilska, Dijana
    Macedonian Acad Sci & Arts, Res Ctr Genet Engn & Biotechnol Georgi DEfremov, Blvd Krste Petkov Misirkov, Skopje 1000, Macedonia.
    Pring, Miranda
    Univ Bristol, Bristol Dent Sch, Lower Maudlin St, Bristol BS1 2LY, Avon, England.
    Prokofyeva, Darya
    Bashkir State Univ, Dept Genet & Fundamental Med, ulZaki Validi 32, Ufa 450076, Russia.
    Radice, Paolo
    INT, Fdn IRCCS, Dept Res, Unit Mol Bases Genet Risk & Genet Testing, Via Giacomo Venezian 1, I-20133 Milan, Italy.
    Stefansson, Kari
    Decode Genet, Sturlugata 8, IS-101 Reykjavik, Iceland.
    Ramus, Susan J.
    Univ NSW Sydney, Sch Womens & Childrens Hlth, Fac Med, 18 High St, Sydney, NSW 2052, Australia;Garvan Inst Med Res, Kinghorn Canc Ctr, 384 Victoria St, Sydney, NSW 2010, Australia.
    Raskin, Leon
    Vanderbilt Univ, Sch Med, Vanderbilt Ingram Canc Ctr, Div Epidemiol,Dept Med,Vanderbilt Epidemiol Ctr, 1161 21st Ave S D3300, Nashville, TN 37232 USA.
    Rennert, Gad
    Carmel Hosp, Clalit Natl Canc Control Ctr, 7 Michal St, IL-34362 Haifa, Israel;Technion Fac Med, 7 Michal St, IL-34362 Haifa, Israel.
    Rennert, Hedy S.
    Carmel Hosp, Clalit Natl Canc Control Ctr, 7 Michal St, IL-34362 Haifa, Israel;Technion Fac Med, 7 Michal St, IL-34362 Haifa, Israel.
    van Rensburg, Elizabeth J.
    Univ Pretoria, Dept Genet, Private Bag X323, ZA-0007 Arcadia, South Africa.
    Riggan, Marjorie J.
    Duke Univ, Dept Obstet & Gynecol, Med Ctr, 25171 Morris Bldg, Durham, NC 27710 USA.
    Risch, Harvey A.
    Yale Sch Publ Hlth, Dept Chron Dis Epidemiol, 60 Coll St, New Haven, CT 06510 USA.
    Risch, Angela
    Salzburg Univ, Dept Mol Biol, Canc Ctr Cluster Salzburg, PLUS, Billrothstr11, A-5020 Salzburg, Austria;DKFZ German Canc Res Ctr, Div Epigen & Canc Risk Factors, Neuenheimer Feld 280, D-69120 Heidelberg, Germany;German Ctr Lung Res DZL, TLRC H, D-69120 Heidelberg, Germany.
    Roobol, Monique J.
    Erasmus Univ, Med Ctr, Dept Urol, Wytemaweg 80, NL-3015 CN Rotterdam, Netherlands.
    Rosenstein, Barry S.
    Icahn Sch Med Mt Sinai, Dept Radiat Oncol, 1425 Madison Ave, New York, NY 10029 USA;Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, 1425 Madison Ave, New York, NY 10029 USA.
    Rossing, Mary Anne
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Program Epidemiol, 1100 Fairview Ave N, Seattle, WA 98109 USA;Univ Washington, Dept Epidemiol, M4 C308,1100 Fairview Ave N, Seattle, WA 98109 USA.
    De Ruyck, Kim
    Univ Ghent, Fac Med & Hlth Sci, Basic Med Sci, De Pintelaan 185, B-9000 Ghent, Belgium.
    Saloustros, Emmanouil
    Univ Hosp Heraklion, Hereditary Canc Clin, Iraklion 71110, Greece.
    Sandler, Dale P.
    NIEHS, Epidemiol Branch, NIH, 111TWAlexander Dr, Res Triangle Pk, NC 27709 USA.
    Sawyer, Elinor J.
    Kings Coll London, Guys Hosp, Guys Hosp Great Maze Pond, Res Oncol, London SE1 9RT, England.
    Schabath, Matthew B.
    HLee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, 12902 Magnolia Dr, Tampa, FL 33612 USA.
    Schleutker, Johanna
    Univ Turku, Inst Biomed, Turku 20014, Finland;Turku Univ Hosp, Dept Med Genet, Div Lab, Turku 20014, Finland;Univ Tampere, Fac Med & Life Sci, Prostate Canc Res Ctr, Tampere 33014, Finland;Univ Tampere, BioMediTech Inst, Tampere 33014, Finland.
    Schmidt, Marjanka K.
    Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Div Mol Pathol, Plesmanlaan 121, NL-1066 CX Amsterdam, Netherlands;Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Div Psychosocial Res & Epidemiol, Plesmanlaan 121, NL-1066 CX Amsterdam, Netherlands.
    Setiawan, V. Wendy
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, 1450 Biggy St, Los Angeles, CA 90033 USA.
    Shen, Hongbing
    Nanjing Med Univ, Collaborat Innovat Ctr Canc Personalized Med, Jiangsu Key Lab Canc Biomarkers Prevent & Treatme, Dept Epidemiol & Biostat,Sch Publ Hlth, 101 Longmian Ave, Nanjing 211166, Jiangsu, Peoples R China.
    Siegel, Erin M.
    H Lee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, 12902 Magnolia Dr MRC CANCONT, Tampa, FL 33612 USA.
    Sieh, Weiva
    Icahn Sch Med Mt Sinai, Dept Populat Hlth Sci & Policy, Dept Genet & Genom Sci, 1425 Madison Ave,2nd Floor, New York, NY 10029 USA.
    Singer, Christian F.
    Med Univ Vienna, Dept OB GYN, Waehringer Guertel 18-20, A-1090 Vienna, Austria;Med Univ Vienna, Ctr Comprehens Canc, Waehringer Guertel 18-20, A-1090 Vienna, Austria.
    Slattery, Martha L.
    Univ Utah, Dept Internal Med, Hlth Sci Ctr, 295 Chipeta Way, Salt Lake City, UT 84132 USA.
    Sorensen, Karina Dalsgaard
    Aarhus Univ Hosp, Dept Mol Med, DK-8200 Aarhus, Denmark;Aarhus Univ, Dept Clin Med, DK-8200 Aarhus, Denmark.
    Southey, Melissa C.
    Monash Univ, Sch Clin Sci, Precis Med, Monash Hlth, 246 Clayton Rd, Clayton, Vic 3168, Australia;Univ Melbourne, Dept Clin Pathol, Cnr Grattan St, Melbourne, Vic 3010, Australia;Royal Parade, Melbourne, Vic 3010, Australia.
    Spurdle, Amanda B.
    QIMR Berghofer Med Res Inst, Dept Genet & Computat Biol, 300 Herston Rd, Brisbane, Qld 4006, Australia.
    Stanford, Janet L.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1100 Fairview Ave N, Seattle, WA 98109 USA;Univ Washington, Sch Publ Hlth, Dept Epidemiol, 1959 NE Pacific St, Seattle, WA 98195 USA.
    Stevens, Victoria L.
    Amer Canc Soc, Epidemiol Res Program, 250 Williams St NW, Atlanta, GA 30303 USA.
    Stintzing, Sebastian
    Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Med 3, Marchioninistr15, D-81377 Munich, Germany.
    Stone, Jennifer
    Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Level 1,723 Swanston St, Melbourne, Vic 3010, Australia;Curtin Univ, Curtin UWA Ctr Genet Origins Hlth & Dis, 35 Stirling Hwy, Perth, WA 6000, Australia;Univ Western Australia, 35 Stirling Hwy, Perth, WA 6000, Australia.
    Sundfeldt, Karin
    Univ Gothenburg, Inst Clin Sci, Sahlgrenska Canc Ctr, Dept Obstet & Gynecol, Bla Straket 6, S-41345 Gothenburg, Sweden.
    Sutphen, Rebecca
    Univ S Florida, Coll Med, Epidemiol Ctr, 3650 Spectrum Blvd,Suite 100, Tampa, FL 33612 USA.
    Swerdlow, Anthony J.
    Inst Canc Res, Div Genet & Epidemiol, 15 Cotswold Rd, Sutton SM2 5NG, Surrey, England;Inst Canc Res, Div Breast Canc Res, London SW7 3RP, England.
    Tajara, Eloiza H.
    Sch Med Sao Jose do Rio Preto, Dept Mol Biol, Av Brig Faria Lima 5416 Vila Sao Pedro, BR-15090000 Sao Jose Do Rio Preto, SP, Brazil;Univ Sao Paulo, Inst Biosci, Dept Genet & Evolut Biol, Rua Matao 321, BR-05508090 Sao Paulo, SP, Brazil.
    Tangen, Catherine M.
    Fred Hutchinson Canc Res Ctr, SWOG Stat Ctr, Seattle, WA 98109 USA.
    Tardon, Adonina
    Univ Oviedo, Fac Med, Campus Cristo S-N, E-33006 Oviedo, Spain;CIBERESP, Campus Cristo S-N, Oviedo 33006, Spain.
    Taylor, Jack A.
    NIEHS, Epidemiol Branch, NIH, 111TWAlexander Dr, Res Triangle Pk, NC 27709 USA;NIEHS, Epigenet & Stem Cell Biol Lab, NIH, 111TWAlexander Dr, Res Triangle Pk, NC 27709 USA.
    Teare, M. Dawn
    Univ Sheffield, Sch Hlth & Related Res ScHARR, Med Stat Grp, Regent Court,30 Regent St, Sheffield S1 4DA, S Yorkshire, England.
    Teixeira, Manuel R.
    Portuguese Oncol Inst, Dept Genet, Rua DrAntonio Bernardino de Almeida 62, P-4220072 Porto, Portugal;Univ Porto, Biomed Sci Inst ICBAS, RJorge de Viterbo Ferreira 228, P-4050013 Porto, Portugal.
    Terry, Mary Beth
    Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, 722 West 168th St, New York, NY 10032 USA.
    Terry, Kathryn L.
    Brigham & Womens Hosp, Obstet & Gynecol Epidemiol Ctr, 221 Longwood Ave RFB 368, Boston, MA 02115 USA;Harvard THChan Sch Publ Hlth, 221 Longwood Ave RFB 368, Boston, MA 02115 USA.
    Thibodeau, Stephen N.
    Mayo Clin, Dept Lab Med & Pathol, 200 First StSW, Rochester, MN 55905 USA.
    Thomassen, Mads
    Odense Univ Hosp, Dept Clin Genet, Sonder Blvd 29, DK-5000 Odense C, Denmark.
    Bjorge, Line
    Haukeland Hosp, Dept Gynecol & Obstet, N-5021 Bergen, Norway;Univ Bergen, Dept Clin Sci, Ctr Canc Biomarkers CCBIO, N-5021 Bergen, Norway.
    Tischkowitz, Marc
    McGill Univ, Dept Human Genet & Oncol, Program Canc Genet, 1001 Decarie Blvd, Montreal, PQ H4A 3J1, Canada;Univ Cambridge, Dept Med Genet, Hills Rd, Cambridge CB2 0QQ, England.
    Toland, Amanda E.
    Ohio State Univ, Dept Canc Biol & Genet, 460W12th Ave, Columbus, OH 43210 USA.
    Torres, Diana
    German Canc Res Ctr, Mol Genet Breast Canc, Neuenheimer Feld 580, D-69120 Heidelberg, Germany;Pontificia Univ Javeriana, Inst Human Genet, Carrera 7 40-90, Bogota, Colombia.
    Townsend, Paul A.
    Univ Manchester, NIHR Manchester Biomed Res Ctr, Fac Biol Med & Hlth,Manchester Acad Hlth Sci Ctr, Div Canc Sci,Manchester Canc Res Ctr,Hlth Innovat, Manchester M20 4GJ, Lancs, England.
    Travis, Ruth C.
    Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford OX3 7LF, England.
    Tung, Nadine
    Beth Israel Deaconess Med Ctr, Dept Med Oncol, 330 Brookline Ave, Boston, MA 02215 USA.
    Tworoger, Shelley S.
    Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, 677 Huntington Ave, Boston, MA 02115 USA;HLee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, 12902 Magnolia Dr, Tampa, FL 33612 USA.
    Ulrich, Cornelia M.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1100 Fairview Ave N, Seattle, WA 98109 USA;Univ Utah, Huntsman Canc Inst, 2000 Circle Hope,Rm 4125, Salt Lake City, UT 84112 USA;Univ Utah, Dept Populat Hlth Sci, 2000 Circle Hope,Rm 4125, Salt Lake City, UT 84112 USA.
    Usmani, Nawaid
    Int Agcy Res Canc, Genet Epidemiol Grp, 150 Cours Albert Thomas, F-69008 Lyon, France;Univ Alberta, Cross Canc Inst, Dept Oncol, 116 St & 85 Ave, Edmonton, AB T6G 2R3, Canada;Univ Alberta, Cross Canc Inst, Div Radiat Oncol, 116 St & 85 Ave, Edmonton, AB T6G 2R3, Canada.
    Vachon, Celine M.
    Int Agcy Res Canc, Genet Epidemiol Grp, 150 Cours Albert Thomas, F-69008 Lyon, France;Mayo Clin, Dept Hlth Sci Res, 200 First StSW, Rochester, MN 55905 USA.
    Van Nieuwenhuysen, Els
    Univ Hosp Leuven, Dept Obstet & Gynaecol, Div Gynecol Oncol, Herestr 49, B-3000 Leuven, Belgium;Univ Hosp Leuven, Leuven Canc Inst, Herestr 49, B-3000 Leuven, Belgium.
    Vega, Ana
    Biomed Network Rare Dis CIBERER, AvMonforte Lemos,3-5Pabellon 11Planta 0, Madrid 28029, Spain;Fdn Publ Galega Med Xenom, Calle Choupana S-N, Santiago De Compostela 15706, Spain;Inst Invest Sanitaria Santiago de Compostela, Calle Choupana S-N, Santiago De Compostela 15706, Spain.
    Aguado-Barrera, Miguel Elias
    Fdn Publ Galega Med Xenom, Calle Choupana S-N, Santiago De Compostela 15706, Spain;Inst Invest Sanitaria Santiago de Compostela, Calle Choupana S-N, Santiago De Compostela 15706, Spain.
    Wang, Qin
    Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, 2 Worts Causeway, Cambridge CB1 8RN, England.
    Webb, Penelope M.
    QIMR Berghofer Med Res Inst, Populat Hlth Dept, 300 Herston Rd, Brisbane, Qld 4006, Australia.
    Weinberg, Clarice R.
    NIEHS, Biostat & Computat Biol Branch, NIH, 111TWAlexander Dr, Res Triangle Pk, NC 27709 USA.
    Weinstein, Stephanie
    NCI, Div Canc Epidemiol & Genet, 9609 Med Ctr Dr, Rockville, MD 20850 USA.
    Weissler, Mark C.
    Univ N Carolina, Dept Otolaryngol Head & Neck Surg, Chapel Hill, NC 27514 USA.
    Weitzel, Jeffrey N.
    City Hope Clin Canc Genom Community Res Network, 1500 East Duarte Rd, Duarte, CA 91010 USA.
    West, Catharine M. L.
    Univ Manchester, Manchester Acad Hlth Sci Ctr, Christie Hosp NHS Fdn Trust, Div Canc Sci,Manchester Canc Res Ctr, Manchester M13 9PL, Lancs, England.
    White, Emily
    Fred Hutchinson Canc Res Ctr, 1100 Fairview Ave N, Seattle, WA 98109 USA;Univ Washington, Dept Epidemiol, 1100 Fairview Ave N, Seattle, WA 98109 USA.
    Whittemore, Alice S.
    Stanford Univ, Dept Hlth Res & Policy Epidemiol, Sch Med, 259 Campus Dr, Stanford, CA 94305 USA;Stanford Univ, Dept Biomed Data Sci, Sch Med, 259 Campus Dr, Stanford, CA 94305 USA.
    Wichmann, H-Erich
    Ludwig Maximilians Univ Munchen, Inst Med Informat Biometry & Epidemiol, Chair Epidemiol, D-85764 Neuherberg, Germany;Ludwig Maximilians Univ Munchen, Inst Med Informat Biometry & Epidemiol, Chair Epidemiol, Munich, Bavaria, Germany;German Res Ctr Environm Hlth GmbH, Helmholtz Zentrum Munchen, Inst Epidemiol, Ingolstadter Landstr1, D-85764 Neuherberg, Germany;Tech Univ Munich, Inst Med Stat & Epidemiol, D-80333 Munich, Germany.
    Wiklund, Fredrik
    Karolinska Inst, Karolinska Univ Hosp, Dept Med Epidemiol & Biostat, S-17176 Stockholm, Sweden.
    Winqvist, Robert
    Univ Oulu, Lab Canc Genet & Tumor Biol, Canc & Translat Med Res Unit, Bioctr Oulu, Aapistie 5A, SF-90220 Oulu, Finland;Northern Finland Lab Ctr Oulu, Lab Canc Genet & Tumor Biol, Aapistie 5A, Oulu 90220, Finland.
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics. Karolinska Inst, Div Nutr Epidemiol, Dept Environm Med, Nobels Vag 13, S-17177 Stockholm, Sweden.
    Woll, Penella
    Univ Sheffield, Weston Pk Hosp, Acad Unit Clin Oncol, Whitham Rd, Sheffield S10 2SJ, S Yorkshire, England.
    Woods, Michael
    Mem Univ Newfoundland, Discipline Genet, St John, NF A1C 5S7, Canada.
    Wu, Anna H.
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, 1975 Zonal Ave, Los Angeles, CA 90033 USA.
    Wu, Xifeng
    Univ Texas MD Anderson Canc Ctr, Div Canc Prevent & Populat Sci, Dept Epidemiol, 1515 Holcombe Blvd, Houston, TX 77030 USA.
    Yannoukakos, Drakoulis
    Natl Ctr Sci Res Demokritos, Mol Diagnost Lab, INRASTES, Neapoleos 10, Athens 15310, Greece.
    Zheng, Wei
    Vanderbilt Univ, Sch Med, Vanderbilt Ingram Canc Ctr, Div Epidemiol,Dept Med,Vanderbilt Epidemiol Ctr, 1161 21st Ave S D3300, Nashville, TN 37232 USA.
    Zienolddiny, Shanbeh
    Natl Inst Occupat Hlth STAMI, Gydas Vei 8, N-0033 Oslo, Norway.
    Ziogas, Argyrios
    Univ Calif Irvine, Genet Epidemiol Res Inst, Dept Epidemiol, 224 Irvine Hall, Irvine, CA 92617 USA.
    Zorn, Kristin K.
    Univ Pittsburgh, Womens Hosp, Sch Med, 300 Halket St, Pittsburgh, PA 15213 USA.
    Lane, Jacqueline M.
    Broad Inst MIT & Harvard, Program Med & Populat Genet, 75 Ames St, Cambridge, MA 02142 USA;Massachusetts Gen Hosp, Ctr Genom Med, Boston, MA 02114 USA;Massachusetts Gen Hosp, Dept Anasthesia, Boston, MA 02114 USA.
    Saxena, Richa
    Broad Inst MIT & Harvard, Program Med & Populat Genet, 75 Ames St, Cambridge, MA 02142 USA;Massachusetts Gen Hosp, Ctr Genom Med, Boston, MA 02114 USA;Massachusetts Gen Hosp, Dept Anasthesia, Boston, MA 02114 USA.
    Thomas, Duncan
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, 1975 Zonal Ave, Los Angeles, CA 90033 USA.
    Hung, Rayjean J.
    Sinai Hlth Syst, Lunenfeld Tanenbaum Res Inst, Prosserman Ctr Populat Hlth Res, 60 Murray St, Toronto, ON M5T 3L9, Canada;Univ Toronto, Dalla Lana Sch Publ Hlth, Div Epidemiol, 155 Coll St, Toronto, ON M5T 3M7, Canada.
    Diergaarde, Brenda
    Univ Pittsburgh, Grad Sch Publ Hlth, Human Genet, UPMC Canc Pavil,Suite 4C,Off 467,5150 Ctr Ave, Pittsburgh, PA 15232 USA;UPMC Hillman Canc Ctr, Pittsburgh, PA 15232 USA.
    Mckay, James
    Int Agcy Res Canc, Genet Canc Susceptibil Grp, 150 Cours Albert Thomas, F-69008 Lyon, France.
    Peters, Ulrike
    Univ Washington, Sch Publ Hlth, Dept Epidemiol, 1959 NE Pacific St, Seattle, WA 98195 USA.
    Hsu, Li
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1100 Fairview Ave N, Seattle, WA 98109 USA.
    Garcia-Closas, Montserrat
    NCI, Div Canc Epidemiol & Genet, 9609 Med Ctr Dr, Rockville, MD 20850 USA.
    Eeles, Rosalind A.
    Inst Canc Res, Div Genet & Epidemiol, 15 Cotswold Rd, Sutton SM2 5NG, Surrey, England;Inst Canc Res, Oncogenet Team, Downs Rd, Sutton SM2 5NG, Surrey, England;Royal Marsden NHS Fdn Trust, Downs Rd, Sutton SM2 5NG, Surrey, England.
    Chenevix-Trench, Georgia
    QIMR Berghofer Med Res Inst, Dept Genet & Computat Biol, 300 Herston Rd, Brisbane, Qld 4006, Australia.
    Brennan, Paul J.
    Int Agcy Res Canc, Sect Genet, 150 Cours Albert Thomas, F-69008 Lyon, France.
    Haiman, Christopher A.
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Norris Comprehens Canc Ctr, Los Angeles, CA 48109 USA.
    Simard, Jacques
    Univ Laval, Res Ctr, Ctr Hosp Univ Quebec, Genom Ctr, 2705 Laurier Blvd, Quebec City, PQ G1V 4G2, Canada.
    Easton, Douglas F.
    Univ Cambridge, Dept Oncol, Ctr Canc Genet Epidemiol, 2 Worts Causeway, Cambridge CB1 8RN, England;Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, 2 Worts Causeway, Cambridge CB1 8RN, England.
    Gruber, Stephen B.
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, 1975 Zonal Ave, Los Angeles, CA 90033 USA.
    Pharoah, Paul D. P.
    Univ Cambridge, Dept Oncol, Ctr Canc Genet Epidemiol, 2 Worts Causeway, Cambridge CB1 8RN, England;Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, 2 Worts Causeway, Cambridge CB1 8RN, England.
    Price, Alkes L.
    Harvard TH Chan Sch Publ Hlth, Program Genet Epidemiol & Stat Genet, 677 Huntington Ave, Boston, MA 02115 USA;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, 677 Huntington Ave, Boston, MA 02115 USA;Broad Inst MIT & Harvard, Program Med & Populat Genet, 75 Ames St, Cambridge, MA 02142 USA.
    Pasaniuc, Bogdan
    Univ Calif Los Angeles, UCLA Path & Lab Med, 10833 Le Conte Ave, Los Angeles, CA 19009 USA.
    Amos, Christopher I.
    Baylor Coll Med, Inst Clin & Translat Res, Epidemiol Sect, Dept Med, One Baylor Plaza,MS BCM451,Suite 100D, Houston, TX 77030 USA.
    Kraft, Peter
    Harvard TH Chan Sch Publ Hlth, Program Genet Epidemiol & Stat Genet, 677 Huntington Ave, Boston, MA 02115 USA;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, 677 Huntington Ave, Boston, MA 02115 USA.
    Lindstrom, Sara
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1100 Fairview Ave N, Seattle, WA 98109 USA;Univ Washington, Sch Publ Hlth, Dept Epidemiol, 1959 NE Pacific St, Seattle, WA 98195 USA.
    Shared heritability and functional enrichment across six solid cancers2019In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 10, article id 431Article in journal (Refereed)
    Abstract [en]

    Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (r(g) = 0.57, p = 4.6 x 10(-8)), breast and ovarian cancer (r(g) = 0.24, p = 7 x 10(-5)), breast and lung cancer (r(g) = 0.18, p = 1.5 x 10(-6)) and breast and colorectal cancer (r(g) = 0.15, p = 1.1 x 10(-4)). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis.

  • 20.
    Kaluza, J
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences.
    Håkansson, N
    Harris, H R
    Orsini, N
    Michaëlsson, Karl
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences.
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Influence of anti-inflammatory diet and smoking on mortality and survival in men and women: two prospective cohort studies.2019In: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 285, no 1, p. 75-91Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: The associations between an anti-inflammatory diet and both all-cause and cause-specific mortality have been studied previously; however, the influence of an anti-inflammatory diet on survival time has not been investigated. Moreover, the potential modification of these associations by smoking status remains unclear.

    OBJECTIVE: The aims of this study were to examine the associations between an anti-inflammatory diet index (AIDI) and all-cause and cause-specific mortality, to determine the association between the AIDI and differences in survival time and to assess effect modification by smoking status.

    METHODS: The study population included 68 273 Swedish men and women (aged 45-83 years) at baseline. The anti-inflammatory potential of the diet was estimated using the validated AIDI, which includes 11 potential anti-inflammatory and five potential pro-inflammatory foods. Cox proportional hazards and Laplace regression were used to estimate hazard ratios and differences in survival time.

    RESULTS: During 16 years of follow-up (1 057 959 person-years), 16 088 deaths [5980 due to cardiovascular disease (CVD) and 5252 due to cancer] were recorded. Participants in the highest versus lowest quartile of the AIDI had lower risks of all-cause (18% reduction, 95% CI: 14-22%), CVD (20%, 95% CI: 14-26%) and cancer (13%, 95% CI: 5-20%) mortality. The strongest inverse associations between the highest and lowest quartiles of AIDI and risk of mortality were observed in current smokers: 31%, 36% and 22% lower risks of all-cause, CVD and cancer mortality, respectively. The difference in survival time between current smokers in the lowest AIDI quartile and never smokers in the highest quartile was 4.6 years.

    CONCLUSION: Adherence to a diet with high anti-inflammatory potential may reduce all-cause, CVD and cancer mortality and prolong survival time especially amongst smokers.

  • 21. Kaluza, Joanna
    et al.
    Harris, Holly
    Linden, Anders
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics. Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol, S-17177 Stockholm, Sweden.
    Long-term unprocessed and processed red meat consumption and risk of chronic obstructive pulmonary disease: a prospective cohort study of women2019In: European Journal of Nutrition, ISSN 1436-6207, E-ISSN 1436-6215, Vol. 58, no 2, p. 665-672Article in journal (Refereed)
    Abstract [en]

    PURPOSE: Limited studies have examined red meat consumption in relation to risk of chronic obstructive pulmonary disease (COPD), and none have examined the impact of long-term diet on COPD risk. We sought to investigate the association between long-term red meat consumption and risk of COPD.

    METHODS: The population-based prospective Swedish Mammography Cohort included 34,053 women, aged 48-83 years, followed for the current analyses from 2002 to 2014. Unprocessed and processed red meat consumption was assessed with a self-administered questionnaire in 1987 and 1997. Cox proportional hazard models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).

    RESULTS: Over a mean follow-up of 11.6 years (2002-2014; 393,831 person-years), 1488 COPD cases were ascertained via linkage to the Swedish health registers. A positive association between long-term processed red meat (average from 1987 to 1997) and risk of COPD was observed. In contrast, no association was observed with unprocessed red meat with corresponding HRs of 1.36 (95% CI 1.03-1.79) for processed and 0.87 (95% CI 0.74-1.02) for unprocessed red meat among women who consumed ≥ 50 g/day compared to < 25 g/day. The observed association with processed meat was confined to ex-smokers (P for interaction = 0.30); women consuming of ≥ 50 g/day of processed meat had a 2.3-fold (95% CI 1.24-4.12) higher risk of COPD than those consuming < 25 g/day. No similar associations were observed among current or never smokers.

    CONCLUSION: In this prospective cohort of women with moderate red meat consumption, long-term processed red meat consumption was associated with an increased risk of COPD particularly among ex-smokers.

  • 22.
    Kaluza, Joanna
    et al.
    Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol, Stockholm, Sweden.; Warsaw Univ Life Sci SGGW, Dept Human Nutr, Nutr Res Lab, 159C Nowoursynowska St, PL-02776 Warsaw, Poland..
    Harris, Holly
    Fred Hutchinson Canc Res Ctr, Program Epidemiol, Div Publ Hlth Sci, Seattle, WA 98104 USA.
    Melhus, Håkan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical pharmacogenomics and osteoporosis.
    Michaëlsson, Karl
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics. Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol, Stockholm, Sweden.
    Questionnaire-Based Anti-Inflammatory Diet Index as a Predictor of Low-Grade Systemic Inflammation.2018In: Antioxidants and Redox Signaling, ISSN 1523-0864, E-ISSN 1557-7716, Vol. 28, no 1, p. 78-84Article in journal (Refereed)
    Abstract [en]

    There is accumulating evidence that diet may be associated with markers of inflammation. We have evaluated if an empirically developed questionnaire-based Anti-Inflammatory Diet Index (AIDI) may predict low-grade systemic chronic inflammation in a Nordic population. The AIDI was developed using a 123-item food frequency questionnaire among 3503 women (56-74 years old) with high-sensitivity C-reactive protein (hsCRP) plasma concentration <20 mg/L. Using Spearman correlations, we identified 20 foods (AIDI-20) statistically significantly related to hsCRP. The median (range) of AIDI-20 was 8 (0-17) scores, and the median concentration of hsCRP in the lowest versus the highest quintile of AIDI-20 (≤6 vs. ≥11 scores) varied by 80% (1.8 vs. 1.0 mg/L, respectively). In a multivariable-adjusted linear regression model, women in the highest quintile of AIDI-20 compared with those in the lowest had a 26% (95% confidence interval [CI] 18-33%; p-trend <0.001) lower hsCRP concentration; each 1-score increment in the AIDI-20 was associated with a 0.06 (95% CI 0.04-0.08) mg/L lower hsCRP. The observed association between the AIDI-20 and hsCRP was robust by all hsCRP levels and in subgroups defined by inflammatory-related factors. Our results lead to the hypothesis that the empirically developed questionnaire-based dietary anti-inflammatory index may predict low-grade systemic inflammation. Antioxid. Redox Signal. 28, 78-84.

  • 23.
    Kaluza, Joanna
    et al.
    Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol, SE-17177 Stockholm, Sweden;Warsaw Univ Life Sci SGGW, Dept Human Nutr, Nutr Res Lab, Warsaw, Poland.
    Harris, Holly R
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Program Epidemiol, 1124 Columbia St, Seattle, WA 98104 USA.
    Linden, Anders
    Karolinska Inst, Inst Environm Med, Unit Lung & Airway Res, SE-17177 Stockholm, Sweden;Karolinska Univ Hosp, Lung Allergy Clin, Stockholm, Sweden.
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics. Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol, SE-17177 Stockholm, Sweden.
    Long-term consumption of fruits and vegetables and risk of chronic obstructive pulmonary disease: a prospective cohort study of women2018In: International Journal of Epidemiology, ISSN 0300-5771, E-ISSN 1464-3685, Vol. 47, no 6, p. 1897-1909Article in journal (Refereed)
    Abstract [en]

    Background: Fruits and vegetables, due to high antioxidant capacity, may protect the lung from oxidative damage caused by tobacco smoke and potentially prevent chronic obstructive pulmonary disease (COPD). Only one study based on baseline diet has examined fruit and vegetable consumption in relation to risk of COPD, and no previous studies have examined long-term diet.

    Methods: We investigated whether long-term fruit and vegetable consumption was associated with COPD incidence among 34 739 women (age 48-83 years) in the population-based prospective Swedish Mammography Cohort. Fruit and vegetable consumption was assessed twice (1987, 1997) with a self-administered questionnaire. Cases of COPD were identified by linkage to the Swedish health register. Cox proportional hazard regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).

    Results: During follow-up from 2002 to 2014, 1512 women were diagnosed with COPD. Long-term fruit was associated with lower risk of COPD; women in the highest vs lowest quintile of consumption (≥2.5 vs <0.8 servings/day) had a 37% lower risk of COPD (95% CI: 25-48%; P-trend < 0.0001). No association was observed with long-term vegetable intake. Current and ex-smokers with low long-term consumption of fruits (<1 serving/day) in comparison to never smokers with high consumption (≥3 servings/day) had a 38-fold (HR: 38.1; 95% CI: 20.2-71.7) and 13-fold (HR: 12.5, 95% CI: 6.5-24.1) higher risk of COPD, respectively. However, no significant interaction between smoking status and fruit intake in relation to COPD incidence was observed (P-interaction = 0.95).

    Conclusions: In this prospective cohort of middle-age and older women, long-term consumption of fruits but not vegetables was inversely associated with COPD incidence.

  • 24. Kaluza, Joanna
    et al.
    Harris, Holly
    Wallin, Alice
    Linden, Anders
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics. Karolinska Inst, Unit Nutr Epidemiol, Inst Environm Med, Stockholm, Sweden.
    Dietary Fiber Intake and Risk of Chronic Obstructive Pulmonary Disease: A Prospective Cohort Study of Men.2018In: Epidemiology, ISSN 1044-3983, E-ISSN 1531-5487, Vol. 29, no 2, p. 254-260Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: The limited literature suggests that dietary fiber intake from whole grains, fruits, and vegetables is negatively associated with chronic obstructive pulmonary disease (COPD) via fiber's anti-inflammatory properties. Therefore, we investigated the association between total fiber and fiber sources and risk of COPD in the population-based prospective Cohort of Swedish Men (45,058 men, aged 45-79 years) with no history of COPD at baseline.

    METHODS: Dietary fiber intake was assessed with a self-administered questionnaire in 1997 and was energy-adjusted using the residual method. Cox proportional hazard regression models were used to estimate hazard ratios (HRs) with 95% confidence intervals (95% CIs) adjusted for potential confounders.

    RESULTS: During a mean follow-up of 13.1 years (1998-2012), 1,982 incident cases of COPD were ascertained via linkage to the Swedish health registers. A strong inverse association between total fiber intake (≥36.8 vs. <23.7 g/day) and COPD was observed in current smokers (hazard ratio [HR]=0.54; 95% confidence interval [CI]=0.43-0.67) and ex-smokers (HR=0.62, 95%CI=0.50-0.78) but not in never smokers (HR=0.93; 95%CI=0.60-1.45;P-interaction=0.04). For cereal fiber, HRs for highest vs. lowest quintile were 0.62 (95%CI=0.51-0.77,P-trend<0.001) in current smokers and 0.66 (95%CI=0.52-0.82,P-trend<0.001) in ex-smokers; for fruit fiber the HR was 0.65 (95%CI=0.52-0.81,P-trend<0.001) in current smokers and 0.77 (95%CI=0.61-0.98,P-trend=0.17) in ex-smokers; for vegetable fiber it was 0.71 (95%CI=0.57-0.88,P-trend=0.003) in current smokers and 0.92 (95%CI=0.71-1.19,P-trend=0.48) in ex-smokers.

    CONCLUSION: Our findings indicate that high fiber intake was inversely associated with COPD incidence in men who are current or ex-smokers.

  • 25. Kaluza, Joanna
    et al.
    Larsson, Susanna C
    Orsini, Nicola
    Linden, Anders
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Fruit and vegetable consumption and risk of COPD: a prospective cohort study of men.2017In: Thorax, ISSN 0040-6376, E-ISSN 1468-3296, Vol. 72, no 6, p. 500-509Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Antioxidants present in fruits and vegetables may protect the lung from oxidative damage and prevent COPD.

    AIMS: To determine the association between fruit and vegetable consumption and risk of COPD by smoking status in men.

    METHODS: The population-based prospective Cohort of Swedish Men included 44 335 men, aged 45-79 years, with no history of COPD at baseline. Fruit and vegetable consumption was assessed with a self-administered questionnaire.

    RESULTS: During a mean follow-up of 13.2 years, 1918 incident cases of COPD were ascertained. A strong inverse association between total fruit and vegetable consumption and COPD was observed in smokers but not in never-smokers (p-interaction=0.02). The age-standardised incidence rate per 100 000 person-years in the lowest quintile (<2 servings/day) of total fruit and vegetable consumption was 1166 in current smokers and 506 in ex-smokers; among those in the highest quintile (≥5.3 servings/day), 546 and 255 per 100 000 person-years, respectively. The multivariable HR of COPD comparing extreme quintiles of total fruit and vegetable consumption was 0.60 (95% CI 0.47 to 0.76, p-trend <0.0001) in current smokers and 0.66 (95% CI 0.51 to 0.85, p-trend=0.001) in ex-smokers. Each one serving per day increment in total fruit and vegetable consumption decreased risk of COPD significantly by 8% (95% CI 4% to 11%) in current smokers and by 4% (95% CI 0% to 7%) in ex-smokers.

    CONCLUSIONS: These results indicate that high consumption of fruits and vegetables is associated with reduced COPD incidence in both current and ex-smokers but not in never-smokers.

  • 26. Katsoulis, M
    et al.
    Benetou, V
    Karapetyan, T
    Feskanich, D
    Grodstein, F
    Pettersson-Kymmer, U
    Eriksson, S
    Wilsgaard, T
    Jørgensen, L
    Ahmed, L A
    Schöttker, B
    Brenner, H
    Bellavia, A
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Kubinova, R
    Stegeman, B
    Bobak, M
    Boffetta, P
    Trichopoulou, A
    Excess mortality after hip fracture in elderly persons from Europe and the USA: the CHANCES project.2017In: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 281, no 3, p. 300-310Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Hip fractures are associated with diminished quality of life and survival especially amongst the elderly.

    OBJECTIVE: All-cause mortality after hip fracture was investigated to assess its magnitude.

    METHODS: A total of 122 808 participants from eight cohorts in Europe and the USA were followed up for a mean of 12.6 years, accumulating 4273 incident hip fractures and 27 999 deaths. Incident hip fractures were assessed through telephone interviews/questionnaires or national inpatient/fracture registries, and causes of death were verified with death certificates. Cox proportional hazards models and the time-dependent variable methodology were used to assess the association between hip fracture and mortality and its magnitude at different time intervals after the injury in each cohort. We obtained the effect estimates through a random-effects meta-analysis.

    RESULTS: Hip fracture was positively associated with increased all-cause mortality; the hazard ratio (HR) in the fully adjusted model was 2.12, 95% confidence interval (CI) 1.76-2.57, after adjusting for potential confounders. This association was stronger amongst men [HR: 2.39, 95% CI: 1.72-3.31] than amongst women [HR: 1.92, 95% CI: 1.54-2.39], although this difference was not significant. Mortality was higher during the first year after the hip fracture [HR: 2.78, 95% CI: 2.12-3.64], but it remained elevated without major fluctuations after longer time since hip fracture [HR (95% CI): 1.89 (1.50-2.37) after 1-4 years; 2.15 (1.81-2.55) after 4-8 years; 1.79 (1.57-2.05) after 8 or more years].

    CONCLUSION: In this large population-based sample of older persons across eight cohorts, hip fracture was associated with excess short- and long-term all-cause mortality in both sexes.

  • 27. Khalili, Hamed
    et al.
    Hakansson, Niclas
    Chan, Simon S
    Ludvigsson, Jonas F
    Olen, Ola
    Chan, Andrew T
    Hart, Andrew R
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    No Association Between Consumption of Sweetened Beverages and Risk of Later-Onset Crohn's Disease or Ulcerative Colitis.2019In: Clinical Gastroenterology and Hepatology, ISSN 1542-3565, E-ISSN 1542-7714, Vol. 17, no 1, p. 123-129Article in journal (Refereed)
    Abstract [en]

    BACKGROUND & AIMS: Consumption of sweetened beverages has been associated with inflammation based on measurements of C-reactive protein and tumor necrosis factor, as well as immune-mediated disorders including rheumatoid arthritis. We investigated associations with Crohn's disease (CD) or ulcerative colitis (UC).

    METHODS: We conducted a prospective cohort study of 83,042 participants (age, 44-83 y) enrolled in the Cohort of Swedish Men or the Swedish Mammography Study. Dietary and lifestyle data were collected using a validated food frequency questionnaire at baseline in 1997. Diagnoses of CD and UC were ascertained from the Swedish Patient Register. We used Cox proportional hazards modeling to calculate hazard ratios and 95% CIs.

    RESULTS: Through December of 2014, we confirmed 143 incident cases of CD (incidence rate, 11 cases/100,000 person-years) and 349 incident cases of UC (incidence rate, 28 cases/100,000 person-years) over 1,264,345 person-years of follow-up evaluation. Consumption of sweetened beverages was not associated with increased risk of CD (Ptrend = .34) or UC (Ptrend = .40). Compared with participants who reported no consumption of sweetened beverages, the multivariable-adjusted hazard ratios for 1 or more servings per day were 1.02 for CD (95% CI, 0.60-1.73) and 1.14 for UC (95% CI, 0.83-1.57). The association between consumption of sugar-sweetened beverages and risk of CD or UC were not modified by age, sex (cohort), body mass index, or smoking (all Pinteraction ≥ .12).

    CONCLUSIONS: In analyses of data from 2 large prospective cohort studies from Sweden, we observed no evidence for associations between consumption of sweetened beverages and later risk of CD or UC.

  • 28.
    Khalili, Hamed
    et al.
    Harvard Med Sch, Gastroenterol Unit, Clin & Translat Epidemiol Unit, Massachusetts Gen Hosp, Boston, MA 02115 USA;Karolinska Inst, Clin Epidemiol Unit, Dept Med Solna, Inst Environm Med, Stockholm, Sweden.
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics. Karolinska Inst, Dept Med Epidemiol & Biostat, Inst Environm Med, Stockholm, Sweden.
    Reply to: The Association Between Consumption of Sweetened Beverages and the Risk of Inflammatory Bowel Disease2018In: Clinical Gastroenterology and Hepatology, ISSN 1542-3565, E-ISSN 1542-7714, Vol. 16, no 10, p. 1682-1682Article in journal (Other academic)
  • 29. Larsson, S C
    et al.
    Kaluza, J
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Combined impact of healthy lifestyle factors on lifespan: two prospective cohorts.2017In: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 282, no 3, p. 209-219Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: The impact of multiple healthy lifestyle factors on survival time is unclear.

    OBJECTIVE: The aim of this study was to examine differences in survival time associated with a healthy lifestyle versus a less healthy lifestyle.

    METHODS: This study consisted of 33 454 men (Cohort of Swedish Men) and 30 639 women (Swedish Mammography Cohort) aged 45-83 years and free of cancer and cardiovascular disease at baseline. The healthy lifestyle factors included the following: (i) nonsmoking; (ii) physical activity at least 150 min per week; (iii) alcohol consumption of 0-14 drinks per week; (iv) and healthy diet defined as a modified Dietary Approaches to Stop Hypertension Diet score above the median. Cox proportional hazards regression models and Laplace regression were used to estimate, respectively, hazard ratios of all-cause mortality and differences in survival time.

    RESULTS: During follow-up from 1998 through 2014, 8630 deaths amongst men and 6730 deaths amongst women were ascertained through linkage to the Swedish Cause of Death Register. Each of the four healthy lifestyle factors was inversely associated with all-cause mortality and increased survival time. Compared with individuals with no or one healthy lifestyle factor, the multivariable hazard ratios of all-cause mortality for individuals with all four health behaviours were 0.47 (95% 95% confidence interval [CI]: 0.44-0.51) in men and 0.39 (95% CI: 0.35-0.44) in women. This corresponded to a difference in survival time of 4.1 (95% CI: 3.6-4.6) years in men and 4.9 (95% CI: 4.3-5.6) years in women.

    CONCLUSION: Adopting healthy lifestyle behaviours may markedly increase lifespan.

  • 30. Larsson, S C
    et al.
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Bäck, M
    Alcohol consumption, cigarette smoking and incidence of aortic valve stenosis.2017In: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 282, no 4, p. 332-339Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Alcohol consumption and cigarette smoking are modifiable lifestyle factors with important impact on public health. It is unclear whether these factors influence the risk of aortic valve stenosis (AVS).

    OBJECTIVE: To investigate the associations of alcohol consumption and smoking, including smoking intensity and time since cessation, with AVS incidence in two prospective cohorts.

    METHODS: This analysis was based on data from the Swedish Mammography Cohort and the Cohort of Swedish Men, comprising 69 365 adults without cardiovascular disease at baseline. Participants were followed for AVS incidence and death by linkage to the Swedish National Patient and Causes of Death Registers. Hazard ratios (HR) with 95% confidence intervals (CI) were estimated by Cox proportional hazards regression.

    RESULTS: Over a mean follow-up of 15.3 years, 1249 cases of AVS (494 in women and 755 in men) were recorded. Compared with never drinkers of alcohol (lifelong abstainers), the risk of AVS was significantly lower in current light drinkers (1-6 drinks per week [1 drink = 12 g alcohol]; multivariable HR 0.82; 95% CI: 0.68-0.99). The risk of AVS increased with increasing smoking intensity. Compared with never smokers, the HR was 1.46 (95% CI: 1.16-1.85) in current smokers of ≥30 pack-years. Former smokers who had quit smoking 10 or more years previously had similar risk for AVS as never smokers.

    CONCLUSIONS: This study suggests that current light alcohol consumption is associated with a lower risk of AVS, and indicates that the association between smoking and AVS risk is reversible.

  • 31.
    Larsson, S. C.
    et al.
    Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol, SE-17177 Stockholm, Sweden.
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics. Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol, SE-17177 Stockholm, Sweden;Uppsala Univ, Dept Surg Sci, Uppsala, Sweden.
    Håkansson, N.
    Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol, SE-17177 Stockholm, Sweden.
    Bäck, M.
    Karolinska Inst, Ctr Mol Med, Dept Med, Stockholm, Sweden;Karolinska Univ Hosp, Dept Cardiol, Stockholm, Sweden.
    Coffee consumption and risk of aortic valve stenosis: A prospective study2018In: NMCD. Nutrition Metabolism and Cardiovascular Diseases, ISSN 0939-4753, E-ISSN 1590-3729, Vol. 28, no 8, p. 803-807Article in journal (Refereed)
    Abstract [en]

    Background and aims: Coffee contains many biologically active compounds with potential adverse or beneficial effects on the cardiovascular system. Whether coffee consumption is associated with the risk of aortic valve stenosis (AVS) is unknown. The purpose of this study was therefore to examine the association between coffee consumption and AVS incidence.

    Methods and results: This prospective study included 71 178 men and women who provided information on their coffee consumption through a questionnaire at baseline. Incident cases of AVS were identified through linkage with the Swedish National Patient and Cause of Death Registers. During a mean follow-up of 15.2 years, 1295 participants (777 men and 518 women) were diagnosed with AVS. Coffee consumption was positively associated with risk of AVS in a dose - response manner after adjustment for age, sex, smoking, and other risk factors (P-trend = 0.005). The multivariable hazard ratios were was 1.11 (95% confidence interval 1.04 - 1.19) per 2 cups/day increase of coffee consumption and 1.65 (95% confidence interval 1.10 - 2.48) when comparing the highest (>= 6 cups/day) with the lowest (<0.5 cup/day) category of coffee consumption. The association was not modified by other risk factors.

    Conclusions: This study provides novel evidence that high coffee consumption is associated with an increased risk of AVS.

  • 32.
    Larsson, Susanna C.
    et al.
    Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol, SE-17177 Stockholm, Sweden.
    Drca, Nikola
    Karolinska Inst, Karolinska Univ Hosp, Dept Cardiol, Stockholm, Sweden.
    Björck, Martin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Vascular Surgery.
    Bäck, Magnus
    Karolinska Univ Hosp, Div Valvular & Coronary Dis, Stockholm, Sweden;Karolinska Inst, Dept Med, Ctr Mol Med, Stockholm, Sweden.
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences. Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol, SE-17177 Stockholm, Sweden.
    Nut consumption and incidence of seven cardiovascular diseases2018In: Heart, ISSN 1355-6037, E-ISSN 1468-201X, Vol. 104, no 19, p. 1615-1620Article in journal (Refereed)
    Abstract [en]

    Background Nut consumption has been found to be inversely associated with cardiovascular disease mortality, but the association between nut consumption and incidence of specific cardiovascular diseases is unclear. We examined the association between nut consumption and incidence of seven cardiovascular diseases. Methods This prospective study included 61 364 Swedish adults who had completed a Food Frequency Questionnaire and were followed up for 17 years through linkage with the Swedish National Patient and Death Registers. Results Nut consumption was inversely associated with risk of myocardial infarction, heart failure, atrial fibrillation and abdominal aortic aneurysm in the age-adjusted and sex-adjusted analysis. However, adjustment for multiple risk factors attenuated these associations and only a linear, dose-response, association with atrial fibrillation (p(trend)=0.004) and a non-linear association (p(non-linearity)=0.003) with heart failure remained. Compared with no consumption of nuts, the multivariable HRs (95% CI) of atrial fibrillation across categories of nut consumption were 0.97 (0.93 to 1.02) for 1-3 times/month, 0.88 (0.79 to 0.99) for 1-2 times/week and 0.82 (0.68 to 0.99) for 3times/week. For heart failure, the corresponding HRs (95% CI) were 0.87 (0.80 to 0.94), 0.80 (0.67 to 0.97) and 0.98 (0.76 to 1.27). Nut consumption was not associated with risk of aortic valve stenosis, ischaemic stroke or intracerebral haemorrhage. Conclusions These findings suggest that nut consumption or factors associated with this nutritional behaviour may play a role in reducing the risk of atrial fibrillation and possibly heart failure. Trial registration number NCT01127711 and NCT01127698; Results.

  • 33.
    Larsson, Susanna C
    et al.
    Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
    Drca, Nikola
    Karolinska Inst, Karolinska Univ Hosp, Dept Cardiol, Stockholm, Sweden.
    Jensen-Urstad, Mats
    Karolinska Inst, Karolinska Univ Hosp, Dept Cardiol, Stockholm, Sweden.
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics. Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
    Chocolate consumption and risk of atrial fibrillation: Two cohort studies and a meta-analysis2018In: American Heart Journal, ISSN 0002-8703, E-ISSN 1097-6744, Vol. 195, p. 86-90Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Chocolate consumption has been inconsistently associated with risk of atrial fibrillation (AF). We investigated the association between chocolate consumption and risk of AF in Swedish adults from two cohort studies and conducted a meta-analysis to summarize available evidence from cohort studies on this topic.

    METHODS: Our study population comprised 40,009 men from the Cohort of Swedish Men and 32,486 women from the Swedish Mammography Cohort. Incident AF cases were ascertained through linkage with the Swedish National Patient Register. Published cohort studies of chocolate consumption in relation to risk of AF were identified by a PubMed search through September 14, 2017.

    RESULTS: During a mean follow-up of 14.6 years, AF was diagnosed in 9978 Swedish men and women. Compared with non-consumers, the multivariable hazard ratio of AF for those in the highest category of chocolate consumption (≥3-4 servings/week) was 0.96 (95% CI 0.88-1.04). In a random-effects meta-analysis of 5 cohort studies, including 180,454 participants and 16,356 AF cases, the hazard ratios of AF were 0.97 (95% CI 0.94-1.01) per 2 servings/week increase in chocolate consumption and 0.96 (95% CI 0.90-1.03) for the highest versus lowest category of chocolate consumption.

    CONCLUSION: Available data provide no evidence of an association of chocolate consumption with risk of AF.

  • 34. Larsson, Susanna C
    et al.
    Giovannucci, Edward L
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Coffee Consumption and Risk of Gallbladder Cancer in a Prospective Study.2017In: Journal of the National Cancer Institute, ISSN 0027-8874, E-ISSN 1460-2105, Vol. 109, no 3, p. 1-3Article in journal (Refereed)
    Abstract [en]

    Evidence indicates that coffee consumption may reduce the risk of gallstone disease, which is strongly associated with increased risk of gallbladder cancer. The association between coffee consumption and gallbladder cancer incidence was examined in a prospective cohort study of 72 680 Swedish adults (aged 45 - 83 years) who were free of cancer and reported their coffee consumption at baseline. Gallbladder cancers were ascertained by linkage with the Swedish Cancer Register. The data were analyzed using Cox proportional hazards regression models. Statistical tests were two-sided. During 967 377 person-years of follow-up, 74 gallbladder cancer case patients were identified. Compared with consumption of one or less cups of coffee per day, the multivariable hazard ratios were 0.76 (95% confidence interval [CI] = 0.41 to 1.41) for two cups per day, 0.50 (95% CI = 0.24 to 1.06) for three cups per day, and 0.41 (95% CI = 0.20 to 0.83) for four or more cups per day. In conclusion, coffee consumption is associated with a reduced risk of gallbladder cancer.

  • 35. Larsson, Susanna C
    et al.
    Håkansson, Niclas
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Healthy dietary patterns and incidence of biliary tract and gallbladder cancer in a prospective study of women and men.2017In: European Journal of Cancer, ISSN 0959-8049, E-ISSN 1879-0852, Vol. 70, p. 42-47, article id S0959-8049(16)32496-0Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Whether diet influences the risk of biliary tract cancer (BTC) is unknown. We examined the associations of two healthy dietary patterns, including a modified Dietary Approach to Stop Hypertension (mDASH) diet and a modified Mediterranean (mMED) diet, with the incidence of BTC in a population-based prospective study.

    METHODS: The study population comprised 76,014 Swedish adults who were 45-83 years of age and cancer-free at baseline. The mDASH and mMED diets were calculated from self-reported dietary data collected by a validated food-frequency questionnaire. Cox proportional hazards regression models were used to estimate hazard ratios (HR) with 95% confidence intervals (CI) adjusted for potential confounders.

    RESULTS: Over 1,010,777 person-years (mean 13.3 years) of follow-up, 140 extrahepatic BTC cases (including 77 gallbladder cancers) and 23 intrahepatic BTC cases were ascertained by linkage with the Swedish Cancer Register. Adherence to the mDASH and mMED diets was statistically significantly inversely associated with risk of extrahepatic BTC (Ptrend ≤ 0.0003) and gallbladder cancer (Ptrend ≤ 0.005) but not intrahepatic BTC (Ptrend ≥ 0.11). The multivariable HRs (95% CI) for the highest versus lowest tertile of the mDASH diet were 0.41 (0.26-0.64) for extrahepatic BTC and 0.36 (0.20-0.64) for gallbladder cancer. The corresponding HRs (95% CI) for the mMED diet were respectively 0.41 (0.25-0.67) and 0.42 (0.23-0.79).

    CONCLUSION: Adherence to a healthy diet may play a role in reducing the risk of extrahepatic BTC.

  • 36.
    Larsson, Susanna C.
    et al.
    Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol, S-17177 Stockholm, Sweden.
    Wallin, Alice
    Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol, S-17177 Stockholm, Sweden.
    Håkansson, Niclas
    Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol, S-17177 Stockholm, Sweden.
    Stackelberg, Otto
    Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol, S-17177 Stockholm, Sweden;Stockholm South Gen Hosp, Dept Surg, Stockholm, Sweden.
    Bäck, Magnus
    Karolinska Univ Hosp, Div Valvular & Coronary Dis, Stockholm, Sweden;Karolinska Inst, Ctr Mol Med, Dept Med, Stockholm, Sweden.
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics. Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol, S-17177 Stockholm, Sweden.
    Type 1 and type 2 diabetes mellitus and incidence of seven cardiovascular diseases2018In: International Journal of Cardiology, ISSN 0167-5273, E-ISSN 1874-1754, Vol. 262, p. 66-70Article in journal (Refereed)
    Abstract [en]

    Background: The association between type 1 diabetes mellitus (T1DM) and specific cardiovascular diseases (CVD) is uncertain. Furthermore, data on type 2 diabetes mellitus (T2DM) in relation to risk of aortic valve stenosis, atrial fibrillation, abdominal aortic aneurysm, and intracerebral hemorrhage are scarce and inconclusive. We examined the associations of T1DM and T2DM with incidence of seven CVD outcomes.

    Methods: This study comprised 71,483 Swedish adults from two population-based prospective cohorts. T1DM and T2DM diagnosis and incident CVD cases were ascertained through linkage with the population-based registers.

    Results: T1DM was associated with myocardial infarction (hazard ratio [HR] 3.26; 95% confidence interval [CI] 2.47-4.30), heart failure (HR 2.68; 95% CI 1.76-4.09), and ischemic stroke (HR 2.61; 95% CI 1.80-3.79). Increased risk of myocardial infarction, ischemic stroke, and heart failure was also observed in T2DM patients and the magnitude of the associations increased with longer T2DM duration. T2DM was also associated with an increased risk of aortic valve stenosis (HR 1.34; 95% CI 1.05-1.71) and with lower risk of abdominal aortic aneurysm (HR 0.57; 95% CI 0.40-0.82) and intracerebral hemorrhage (HR 0.51; 95% CI 0.30-0.88). Only long-term T2DM(>= 20 years) was associated with an increased risk of atrial fibrillation (HR 1.44; 95% CI 1.02-2.04).

    Conclusion: T1DM and T2DM are associated with increased risk of major CVD outcomes. Trial registration: The Cohort of Swedish Men and the Swedish Mammography Cohort are registered at clinicaltrials.gov as NCT01127711 and NCT01127698, respectively.

  • 37.
    Larsson, Susanna C
    et al.
    Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
    Wallin, Alice
    Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
    Wolk, Alicja
    Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
    Alcohol consumption and risk of heart failure: Meta-analysis of 13 prospective studies2018In: Clinical Nutrition, ISSN 0261-5614, E-ISSN 1532-1983, Vol. 37, no 4, p. 1247-1251Article in journal (Refereed)
    Abstract [en]

    BACKGROUND & AIMS: Controversy exists on the association between alcohol consumption and risk of heart failure (HF). We carried out a meta-analysis to summarize available prospective data on alcohol consumption and HF.

    METHODS: We searched PubMed for relevant studies published until January 1, 2017. Relative risk (RR) estimates from individual studies were pooled in a random-effects meta-analysis.

    RESULTS: A total of 13 prospective studies, with 13,738 HF cases and 355,804 participants, were included in the meta-analysis. Light alcohol drinking (0.1-7 drinks/week) was inversely associated with risk of HF (RR, 0.86; 95% confidence interval, 0.81-0.90). There was no statistically significant association between moderate (7.1-14 drinks/week), high (14.1-28 drinks/week), or heavy (>28 drinks/week) alcohol consumption and HF risk. Former drinking was associated with an increased risk of HF compared with never or occasional drinking (RR, 1.22; 95% confidence interval, 1.11-1.33).

    CONCLUSIONS: This meta-analysis found that light alcohol drinking was associated with a lower risk of HF. Former drinking was associated with a higher risk of HF.

  • 38. Larsson, Susanna C
    et al.
    Wallin, Alice
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Contrasting association between alcohol consumption and risk of myocardial infarction and heart failure: Two prospective cohorts.2017In: International Journal of Cardiology, ISSN 0167-5273, E-ISSN 1874-1754, Vol. 231, p. 207-210, article id S0167-5273(16)33141-2Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: The potential cardioprotective effect of light-to-moderate alcohol consumption is disputed, and the association between heavy drinking and heart failure (HF) risk is unclear. We examined the association between alcohol consumption and risk of myocardial infarction (MI) and HF in two prospective cohorts.

    METHODS: We analyzed data from the Cohort of Swedish Men (40,590 men) and the Swedish Mammography Cohort (34,022 women). Participants were free of ischemic heart disease and HF at baseline. MI and HF cases were ascertained by linkage with the Swedish National Patient Register. Cox proportional hazards regression model was used to estimate hazard ratios (HRs) with 95% confidence intervals (CIs).

    RESULTS: During follow-up (1998-2010), we ascertained 3678 and 1905 cases of MI and HF, respectively, in men and 1500 and 1328 cases of MI and HF, respectively, in women. Alcohol consumption was inversely associated with MI in both men and women (P trend <0.001); compared with light drinkers, the multivariable HRs were 0.70 (95% CI, 0.56-0.87) in men who consumed >28 drinks/week and 0.32 (95% CI, 0.15-0.67) in women who consumed 15-21 drinks/week. Alcohol consumption was not inversely associated with HF risk. However, in men, the risk of HF was higher in never, former, and heavy drinkers (>28 drinks/week; HR=1.45; 95% CI, 1.09-1.93) compared with light drinkers.

    CONCLUSIONS: Alcohol consumption has divergent associations with MI and HF, with an inverse association observed for MI but not HF. Heavy drinking was associated with an increased HF risk in men.

  • 39. Larsson, Susanna C
    et al.
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Fish, long-chain omega-3 polyunsaturated fatty acid intake and incidence of atrial fibrillation: A pooled analysis of two prospective studies2017In: Clinical Nutrition, ISSN 0261-5614, E-ISSN 1532-1983, Vol. 36, no 2, p. 537-541, article id S0261-5614(16)00046-7Article in journal (Refereed)
    Abstract [en]

    BACKGROUND & AIMS: Whether high intakes of fish and long-chain omega-3 polyunsaturated fatty acids (PUFAs) reduce the risk of atrial fibrillation (AF) remains uncertain. Thus, we aimed to evaluate the associations of total fish, types of fish, and omega-3 PUFA intake with AF incidence in a large prospective study.

    METHODS: We used data from the Cohort of Swedish Men and the Swedish Mammography Cohort to examine the associations of fish consumption and long-chain omega-3 PUFA intake with AF incidence. At baseline, information on fish and omega-3 PUFA intakes was available from 72,984 men and women, aged 45-83 years, without cardiac disease. Cases of AF were identified through linkage with the Swedish National Patient Register. Multivariable-adjusted relative risks were estimated with the use of Cox proportional hazards models.

    RESULTS: Over a follow-up period of 12 years, 6095 participants (3595 men and 2500 women) developed AF. Intakes of total fish, fatty fish (herring/mackerel and salmon/whitefish/char), and long-chain omega-3 PUFAs were not associated with AF incidence after adjustment for other risk factors. However, high consumption of lean fish (cod/saithe/fish fingers) was associated with a lower risk; multivariable relative risk of AF for ≥3 servings/week compared with never consumption was 0.79 (95% confidence interval, 0.65-0.95).

    CONCLUSIONS: These findings do not support a beneficial association of fatty fish or omega-3 PUFA intake with incident AF. The association between lean fish consumption and AF risk warrants further investigation.

  • 40.
    Larsson, Susanna C.
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics. Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol, Stockholm, Sweden.
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics. Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol, Stockholm, Sweden.
    Sedentary leisure-time in relation to mortality and survival time2019In: Journal of Science and Medicine in Sport, ISSN 1440-2440, E-ISSN 1878-1861, Vol. 22, no 5, p. 562-567Article in journal (Refereed)
    Abstract [en]

    Objective: To examine the association between sedentary leisure-time and all-cause mortality and differences in survival time.

    Design: Prospective cohort study.

    Methods: Information on sedentary leisure-time, defined as TV viewing and/or sitting reading, was collected from 72 003 Swedish adults who were 45-83 (median 60) years of age and completed a self-administered questionnaire at baseline and were followed up for 17 years through linkage with the Swedish Death Register.

    Results: The association between sedentary leisure-time and all-cause mortality was modified by age with a more pronounced association in middle-aged (<60 years of age) than in older adults (>= 60 years of age) (p-interaction <0.001). During follow-up, 3358 and 15 217 deaths occurred in the middle-aged and older age group, respectively. The multivariable-adjusted hazard ratios for the highest (>6 h/day) versus lowest category (<1 h/day) of sedentary leisure-time were 1.72 (95% confidence interval [CI] 1.29-2.30) in middle-aged adults and 1.19 (95% CI 1.05-1.36) in older adults. This corresponded to a difference in survival time of respectively 2.4 (95% CI -4.1 to -0.8) years and 1.5 (95% CI -2.2 to -0.7) years.

    Conclusions: Prolonged sedentary leisure-time was associated with a significantly decreased survival time up to 2.4 years in middle-aged adults. 

  • 41. Larsson, Susanna C
    et al.
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    The Role of Lifestyle Factors and Sleep Duration for Late-Onset Dementia: A Cohort Study2018In: Journal of Alzheimer's Disease, ISSN 1387-2877, E-ISSN 1875-8908, Vol. 66, no 2, p. 579-586Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: The role of lifestyle factors and sleep for dementia is uncertain.

    OBJECTIVE: To examine the associations of major lifestyle factors and sleep duration with risk of late-onset dementia.

    METHODS: We used data from a population-based cohort of 28,775 Swedish adults who were ≥65 years of age and completed a questionnaire about lifestyle and other modifiable factors in the autumn of 1997. Dementia cases were ascertained by linkage with the Swedish National Patient Register.

    RESULTS: During a mean follow-up of 12.6 years, dementia was diagnosed among 3,755 participants (mean age at diagnosis 83.2±5.1 years). There were no associations of an overall healthy diet (defined by a modified Dietary Approaches to Stop Hypertension Diet score or a Mediterranean diet score), alcohol and coffee consumption, or physical activity with dementia incidence. Compared with never smokers, dementia risk was increased in former and current smokers (hazard ratio [95% confidence interval] = 1.13 [1.04-1.23] and 1.10 [1.00-1.21], respectively). Extended time of sleep (>9 h per night) was associated with an increased risk of dementia. However, this association appeared to be related to a reverse causation effect since the association did not remain after exclusion of cases diagnosed within the first five or ten years of follow-up.

    CONCLUSIONS: This study found no evidence that major lifestyle factors, aside from smoking, or sleep duration influence the risk of dementia.

  • 42.
    Larsson, Susanna C
    et al.
    Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol, S-17177 Stockholm, Sweden.
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics. Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol, S-17177 Stockholm, Sweden.
    Bäck, Magnus
    Karolinska Univ Hosp, Div Valvular & Coronary Dis, Heart & Vasc Theme, Stockholm, Sweden;Karolinska Inst, Dept Med, Ctr Mol Med, Stockholm, Sweden.
    Dietary patterns, food groups, and incidence of aortic valve stenosis: A prospective cohort study.2019In: International Journal of Cardiology, ISSN 0167-5273, E-ISSN 1874-1754, Vol. 283, p. 184-188Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: The role of diet in the development of aortic valve stenosis (AVS) is unknown. We therefore examined the associations of two dietary patterns, including a modified Dietary Approaches to Stop Hypertension (mDASH) diet and a modified Mediterranean (mMED) diet, and the food items included in these dietary patterns with incidence of aortic valve stenosis (AVS) in a population-based cohort study.

    METHODS: The study cohort comprised 74,401 Swedish adults (54% men) who were free of cardiovascular disease at the time of completion of a baseline questionnaire about habitual diet and other risk factors for chronic diseases. Participants were followed-up through linkage with nationwide registers on hospitalization and causes of death.

    RESULTS: During 1,132,617 person-years (mean 15.2 years) of follow-up, 1338 incident AVS cases (801 in men and 537 in women) were ascertained. We found no significant associations of the mDASH and mMED dietary patterns or the food groups and beverages included in these diets (i.e., fruit, vegetables, legumes and nuts, whole grains, fish, low-fat dairy foods, full-fat dairy foods, red and processed meat, and sweetened beverages) with risk of AVS. The hazard ratios (95% confidence interval) of AVS per one standard deviation increase in the mDASH and mMED diet scores were respectively 1.02 (0.96-1.07) and 1.00 (0.95-1.06).

    CONCLUSION: This study found no evidence that diet plays a role in the development of AVS.

  • 43. Larsson, Susanna C
    et al.
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Håkansson, Niclas
    Bäck, Magnus
    Overall and abdominal obesity and incident aortic valve stenosis: two prospective cohort studies.2017In: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 38, no 28, p. 2192-2197Article in journal (Refereed)
    Abstract [en]

    Aims: The aim of this study was to examine the association of overall and abdominal obesity with aortic valve stenosis (AVS) incidence in two prospective cohorts.

    Methods and results: We used data from the Cohort of Swedish Men and the Swedish Mammography Cohort, involving 71 817 men and women who were free of cardiovascular disease and had reported their anthropometric measures in 1997. Aortic valve stenosis cases were ascertained through linkage with nationwide registers on hospitalization and causes of death. Data were analysed using Cox proportional hazards regression. During a mean follow-up of 15.3 years, 1297 incident AVS cases (771 in men; 526 in women) were ascertained. Both overall and abdominal obesity, measured as body mass index (BMI) and waist circumference, respectively, was associated with AVS incidence, with similar associations in men and women. Compared with BMI 18.5-22.5 kg/m2, the multivariable hazard ratios were 1.24 (95% confidence interval [CI] 1.05-1.48) for overweight (BMI 25.0-29.9 kg/m2) and 1.81 (95% CI 1.47-2.23) for obesity (BMI ≥30 kg/m2). The hazard ratio for substantially increased waist circumference (men: ≥102 cm; women: ≥88 cm) compared with normal waist circumference (men: <94 cm; women: <80 cm) was 1.30 (95% CI 1.12-1.51). The proportion of AVS cases estimated to be attributed to overweight and obesity combined (BMI ≥25 kg/m2) was 10.8% (95% CI 5.2-16.4%).

    Conclusion: These findings indicate that obesity is associated with an increased risk of AVS and that a large proportion of the cases may be prevented if the population maintained a healthy BMI.

  • 44.
    Law, Philip J.
    et al.
    Inst Canc Res, Div Genet & Epidemiol, London SW7 3RP, England.
    Timofeeva, Maria
    Univ Edinburgh, Western Gen Hosp, Med Res Council Human Genet Unit, Insti Genet & Mol Med, Edinburgh EH4 2XU, Midlothian, Scotland.
    Fernandez-Rozadilla, Ceres
    Inst Invest Santiago, Fdn Publ Galega Med Xenom, Grp Med Xenom, Santiago De Compostela 15706, Spain;Univ Birmingham, Inst Canc & Genom Sci, Canc Genet & Evolut Lab, Vincent Dr, Birmingham B15 2TT, W Midlands, England.
    Timofeeva, Aria
    Inst Canc Res, Div Genet & Epidemiol, London SW7 3RP, England.
    Broderick, Peter
    Inst Canc Res, Div Genet & Epidemiol, London SW7 3RP, England.
    Studd, James
    Inst Canc Res, Div Genet & Epidemiol, London SW7 3RP, England.
    Fernandez-Tajes, Juan
    Wellcome Ctr Human Genet, McCarthy Grp, Roosevelt Dr, Oxford OX3 7BN, England.
    Farrington, Susan
    Univ Edinburgh, Western Gen Hosp, Med Res Council Human Genet Unit, Insti Genet & Mol Med, Edinburgh EH4 2XU, Midlothian, Scotland.
    Svinti, Victoria
    Univ Edinburgh, Western Gen Hosp, Med Res Council Human Genet Unit, Insti Genet & Mol Med, Edinburgh EH4 2XU, Midlothian, Scotland.
    Palles, Claire
    Univ Birmingham, Inst Canc & Genom Sci, Gastrointestinal Canc Genet Lab, Vincent Dr, Birmingham B15 2TT, W Midlands, England.
    Orlando, Giulia
    Inst Canc Res, Div Genet & Epidemiol, London SW7 3RP, England.
    Sud, Amit
    Inst Canc Res, Div Genet & Epidemiol, London SW7 3RP, England.
    Holroyd, Amy
    Inst Canc Res, Div Genet & Epidemiol, London SW7 3RP, England.
    Penegar, Steven
    Inst Canc Res, Div Genet & Epidemiol, London SW7 3RP, England.
    Theodoratou, Evropi
    Univ Edinburgh, Western Gen Hosp, Med Res Council Human Genet Unit, Insti Genet & Mol Med, Edinburgh EH4 2XU, Midlothian, Scotland;Univ Edinburgh, Ctr Global Hlth Res, Usher Inst, Edinburgh EH8 9AG, Midlothian, Scotland.
    Vaughan-Shaw, Peter
    Univ Edinburgh, Western Gen Hosp, Med Res Council Human Genet Unit, Insti Genet & Mol Med, Edinburgh EH4 2XU, Midlothian, Scotland.
    Campbell, Harry
    Univ Edinburgh, Western Gen Hosp, Med Res Council Human Genet Unit, Insti Genet & Mol Med, Edinburgh EH4 2XU, Midlothian, Scotland;Univ Edinburgh, Ctr Global Hlth Res, Usher Inst, Edinburgh EH8 9AG, Midlothian, Scotland.
    Zgaga, Lina
    Univ Edinburgh, Western Gen Hosp, Med Res Council Human Genet Unit, Insti Genet & Mol Med, Edinburgh EH4 2XU, Midlothian, Scotland;Univ Dublin, Trinity Coll Dublin, Inst Populat Hlth, Dept Publ Hlth & Primary Care, Dublin D02 PN40, Ireland.
    Hayward, Caroline
    Univ Edinburgh, Western Gen Hosp, Inst Genet & Mol Med, Med Res Council Human Genet Unit, Edinburgh EH4 2XU, Midlothian, Scotland.
    Campbell, Archie
    Univ Edinburgh, Ctr Genom & Expt Med, MRC Inst Genet & Mol Med, Generat Scotland, Edinburgh EH4 2XU, Midlothian, Scotland.
    Harris, Sarah
    Univ Edinburgh, Ctr Genom & Expt Med, MRC Inst Genet & Mol Med, Generat Scotland, Edinburgh EH4 2XU, Midlothian, Scotland;Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh EH8 9JZ, Midlothian, Scotland;Univ Edinburgh, Dept Psychol, Edinburgh EH8 9JZ, Midlothian, Scotland.
    Deary, Ian J.
    Univ Edinburgh, Ctr Genom & Expt Med, MRC Inst Genet & Mol Med, Generat Scotland, Edinburgh EH4 2XU, Midlothian, Scotland;Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh EH8 9JZ, Midlothian, Scotland.
    Starr, Ohn
    Univ Edinburgh, Ctr Genom & Expt Med, MRC Inst Genet & Mol Med, Generat Scotland, Edinburgh EH4 2XU, Midlothian, Scotland;Univ Edinburgh, Ctr Genom & Expt Med, Inst Genet & Mol Med, Med Genet Sect, Edinburgh EH4 2XU, Midlothian, Scotland;Univ Edinburgh, Alzheimer Scotland Dementia Res Ctr, Edinburgh EH8 9JZ, Midlothian, Scotland.
    Gatcombe, Laura
    Univ Birmingham, Inst Canc & Genom Sci, Canc Genet & Evolut Lab, Vincent Dr, Birmingham B15 2TT, W Midlands, England.
    Pinna, Maria
    Univ Birmingham, Inst Canc & Genom Sci, Canc Genet & Evolut Lab, Vincent Dr, Birmingham B15 2TT, W Midlands, England.
    Briggs, Sarah
    Univ Birmingham, Inst Canc & Genom Sci, Canc Genet & Evolut Lab, Vincent Dr, Birmingham B15 2TT, W Midlands, England.
    Martin, Lynn
    Univ Birmingham, Inst Canc & Genom Sci, Canc Genet & Evolut Lab, Vincent Dr, Birmingham B15 2TT, W Midlands, England.
    Jaeger, Emma
    Univ Birmingham, Inst Canc & Genom Sci, Canc Genet & Evolut Lab, Vincent Dr, Birmingham B15 2TT, W Midlands, England.
    Sharma-Oates, Archana
    Univ Birmingham, Inst Canc & Genom Sci, Canc Genet & Evolut Lab, Vincent Dr, Birmingham B15 2TT, W Midlands, England.
    East, James
    Univ Oxford, John Radcliffe Hosp, Nuffield Dept Med, Translat Gastroenterol Unit, Oxford OX3 9DU, England.
    Leedham, Simon
    Wellcome Ctr Human Genet, McCarthy Grp, Roosevelt Dr, Oxford OX3 7BN, England;Univ Edinburgh, Alzheimer Scotland Dementia Res Ctr, Edinburgh EH8 9JZ, Midlothian, Scotland.
    Arnold, Roland
    Univ Birmingham, Inst Canc & Genom Sci, Canc Bioinfomat Lab, Vincent Dr, Birmingham B15 2TT, W Midlands, England.
    Johnstone, Elaine
    Univ Oxford, Dept Oncol, Old Rd Campus,Res Bldg, Oxford OX3 7LE, England.
    Wang, Haitao
    Univ Oxford, Dept Oncol, Old Rd Campus,Res Bldg, Oxford OX3 7LE, England.
    Kerr, David
    Univ Oxford, John Radcliffe Hosp, Nuffield Dept Clin Lab Sci, Oxford OX3 9DU, England.
    Kerr, Rachel
    Univ Oxford, Dept Oncol, Old Rd Campus,Res Bldg, Oxford OX3 7LE, England.
    Maughan, Tim
    Univ Oxford, Dept Oncol, Old Rd Campus,Res Bldg, Oxford OX3 7LE, England.
    Kaplan, Richard
    Med Res Council Clin Trials Unit, Aviat House,125 Kingsway, London WC2B 6NH, England.
    Al-Tassan, Nada
    King Faisal Specialist Hosp & Res Ctr, Dept Genet, Riyadh 11211, Saudi Arabia.
    Palin, Kimmo
    Univ Helsinki, Dept Med & Clin Genet, Res Programs Unit, Med & Genome Scale Biol Res Program, Helsinki 00014, Finland.
    Hanninen, Ulrika A.
    Univ Helsinki, Dept Med & Clin Genet, Res Programs Unit, Med & Genome Scale Biol Res Program, Helsinki 00014, Finland.
    Cajuso, Tatiana
    Univ Helsinki, Dept Med & Clin Genet, Res Programs Unit, Med & Genome Scale Biol Res Program, Helsinki 00014, Finland.
    Tanskanen, Tomas
    Univ Helsinki, Dept Med & Clin Genet, Res Programs Unit, Med & Genome Scale Biol Res Program, Helsinki 00014, Finland.
    Kondelin, Johanna
    Univ Helsinki, Dept Med & Clin Genet, Res Programs Unit, Med & Genome Scale Biol Res Program, Helsinki 00014, Finland.
    Kaasinen, Eevi
    Univ Helsinki, Dept Med & Clin Genet, Res Programs Unit, Med & Genome Scale Biol Res Program, Helsinki 00014, Finland.
    Sarin, Antti-Pekka
    Univ Helsinki, Inst Mol Med Finland FIMM, Helsinki 00014, Finland.
    Eriksson, Johan G.
    Folkhalsan Res Ctr, Helsinki 00250, Finland;Univ Helsinki, Unit Gen Practice & Primary Hlth Care, Helsinki 00014, Finland;Helsinki Univ Hosp, Helsinki 00014, Finland.
    Rissanen, Harri
    Natl Inst Hlth & Welf, Helsinki 00271, Finland.
    Knekt, Paul
    Natl Inst Hlth & Welf, Helsinki 00271, Finland.
    Pukkala, Eero
    Inst Stat & Epidemiol Canc Res, Finnish Canc Registry, Helsinki, Finland;Univ Tampere, Fac Social Sci, Tampere 33014, Finland.
    Jousilahti, Pekka
    Natl Inst Hlth & Welf, Helsinki 00271, Finland.
    Salomaa, Veikko
    Natl Inst Hlth & Welf, Helsinki 00271, Finland.
    Ripatti, Samuli
    Univ Helsinki, Inst Mol Med Finland FIMM, Helsinki 00014, Finland;Univ Helsinki, Dept Publ Hlth, Helsinki 00014, Finland;Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.
    Palotie, Aarno
    Univ Helsinki, Inst Mol Med Finland FIMM, Helsinki 00014, Finland;Massachusetts Gen Hosp, Dept Med, Analyt & Translat Genet Unit, Boston, MA 02114 USA.
    Renkonen-Sinisalo, Laura
    Helsinki Univ Hosp, Abdominal Ctr, Dept Surg, Helsinki 00029, Finland.
    Lepisto, Anna
    Helsinki Univ Hosp, Abdominal Ctr, Dept Surg, Helsinki 00029, Finland.
    Bohm, Jan
    Cent Finland Cent Hosp, Dept Pathol, Jyvaskyla 40620, Finland.
    Mecklin, Jukka-Pekka
    Jyvaskyla Cent Hosp, Dept Surg, Jyvaskyla 40620, Finland;Univ Jyvaskyla, Fac Sport & Hlth Sci, Dept Hlth Sci, Jyvaskyla 40014, Finland.
    Buchanan, Daniel D.
    Univ Melbourne, Dept Clin Pathol, Colorectal Oncogen Grp, Parkville, Vic 3010, Australia;Univ Melbourne, Victorian Comprehens Canc Ctr, Ctr Canc Res, Parkville, Vic 3010, Australia;Royal Melbourne Hosp, Genom Med & Family Canc Clin, Parkville, Vic 3010, Australia.
    Win, Aung-Ko
    Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne, Vic 3010, Australia.
    Hopper, John
    Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne, Vic 3010, Australia.
    Jenkins, Mark E.
    Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne, Vic 3010, Australia.
    Lindor, Noralane M.
    Dept Hlth Sci Res, Mayo Clin, Scottsdale, AZ 85259 USA.
    Newcomb, Polly A.
    Fred Hutchinson Canc Res Ctr, Canc Prevent Program, Seattle, WA 98109 USA.
    Gallinger, Steven
    Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Toronto, ON M5G 1X5, Canada.
    Duggan, David
    Affiliate City Hope, Translat Genom Res Inst TGen, Phoenix, AZ 85004 USA.
    Casey, Graham
    Univ Virginia, Ctr Publ Hlth Genom, Charlottesville, VA 22903 USA.
    Hoffmann, Per
    Univ Basel, Dept Biomed, Human Genom Res Grp, CH-4031 Basel, Switzerland;Univ Bonn, Life & Brain Ctr, Dept Genom, D-53127 Bonn, Germany.
    Nothen, Markus M.
    Univ Bonn, Life & Brain Ctr, Dept Genom, D-53127 Bonn, Germany;Univ Bonn, Inst Human Genet, Sch Med, D-53127 Bonn, Germany;Univ Hosp Bonn, D-53127 Bonn, Germany.
    Jockel, Karl-Heinz
    Univ Hosp Essen, Univ Duisburg Essen, Inst Med Informat Biometry & Epidemiol, D-45147 Essen, Germany.
    Easton, Douglas F.
    Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Oncol, Cambridge CB1 8RN, England;Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge CB1 8RN, England.
    Pharoah, Paul D. P.
    Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Oncol, Cambridge CB1 8RN, England;Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge CB1 8RN, England.
    Peto, Julian
    London Sch Hyg & Trop Med, Dept Noncommunicable Dis Epidemiol, London WC1E 7HT, England.
    Canzian, Federico
    German Canc Res Ctr, Cen Epidemiol Grp, D-69120 Heidelberg, Germany.
    Swerdlow, Anthony
    Inst Canc Res, Div Genet & Epidemiol, London SW7 3RP, England;Inst Canc Res, Div Breast Canc Res, London SW3 6JB, England.
    Eeles, Rosalind A.
    Inst Canc Res, Div Genet & Epidemiol, London SW7 3RP, England;Royal Marsden NHS Fdn Trust, London SW3 6JJ, England.
    Kote-Jarai, Zsofia
    Inst Canc Res, Div Genet & Epidemiol, London SW7 3RP, England.
    Muir, Kenneth
    Univ Manchester, Hlth Serv Res & Primary Care, Div Populat Hlth, Manchester M13 9PL, Lancs, England;Univ Warwick, Warwick Med Sch, Coventry CV4 7HL, W Midlands, England.
    Pashayan, Nora
    UCL, Dept Appl Hlth Res, London WC1E 7H3, England;Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Oncol, Strangeways Lab, Cambridge CB1 8RN, England.
    Harkin, Andrea
    Univ Glasgow, Inst Canc Sci, Canc Res UK Clin Trials Unit, Glasgow G61 1BD, Lanark, Scotland.
    Allan, Karen
    Univ Glasgow, Inst Canc Sci, Canc Res UK Clin Trials Unit, Glasgow G61 1BD, Lanark, Scotland.
    McQueen, John
    Univ Glasgow, Inst Canc Sci, Canc Res UK Clin Trials Unit, Glasgow G61 1BD, Lanark, Scotland.
    Paul, James
    Univ Glasgow, Inst Canc Sci, Canc Res UK Clin Trials Unit, Glasgow G61 1BD, Lanark, Scotland.
    Iveson, Timothy
    Univ Hosp Southampton NHS Fdn Trust, Southampton SO16 6YD, Hants, England.
    Saunders, Mark
    Christie NHS Fdn Trust, Manchester M20 4BX, Lancs, England.
    Butterbach, Katja
    Deutsch Krebsforschungszentrum, Div Clin Epidemiol & Aging Res, D-69120 Heidelberg, Germany.
    Chang-Claude, Jenny
    German Canc Res Ctr, Unit Genet Epidemiol, D-69120 Heidelberg, Germany;Univ Canc Ctr Hamburg, Univ Med Ctr Hamburg Eppendorf, D-20251 Hamburg, Germany.
    Hoffmeister, Michael
    Deutsch Krebsforschungszentrum, Div Clin Epidemiol & Aging Res, D-69120 Heidelberg, Germany.
    Brenner, Hermann
    Deutsch Krebsforschungszentrum, Div Clin Epidemiol & Aging Res, D-69120 Heidelberg, Germany;German Canc Res Ctr, German Canc Consortium DKTK, D-69120 Heidelberg, Germany;German Canc Res Ctr, Div Prevent Oncol, D-69120 Heidelberg, Germany;Natl Ctr Tumor Dis NCT, D-69120 Heidelberg, Germany.
    Kirac, Iva
    Univ Hosp Tumours, Sestre Milosrdnice Univ Hosp Ctr, Dept Surg Oncol, Zagreb 10000, Croatia.
    Matosevic, Petar
    Univ Hosp Ctr Zagreb, Dept Surg, Zagreb 10000, Croatia.
    Hofer, Philipp
    Med Univ Vienna, Inst Canc Res, Dept Med 1, Borschkegasse 8a, A-1090 Vienna, Austria.
    Brezina, Stefanie
    Med Univ Vienna, Inst Canc Res, Dept Med 1, Borschkegasse 8a, A-1090 Vienna, Austria.
    Gsur, Andrea
    Med Univ Vienna, Inst Canc Res, Dept Med 1, Borschkegasse 8a, A-1090 Vienna, Austria.
    Cheadle, Jeremy P.
    Cardiff Univ, Sch Med, Div Canc & Genet, Cardiff CF14 4XN, S Glam, Wales.
    Aaltonen, Lauri A.
    Univ Helsinki, Dept Med & Clin Genet, Res Programs Unit, Med & Genome Scale Biol Res Program, Helsinki 00014, Finland.
    Tomlinson, Ian
    Univ Birmingham, Inst Canc & Genom Sci, Canc Genet & Evolut Lab, Vincent Dr, Birmingham B15 2TT, W Midlands, England.
    Houlston, Richard S.
    Inst Canc Res, Div Genet & Epidemiol, London SW7 3RP, England.
    Dunlop, Malcolm G.
    Univ Edinburgh, Western Gen Hosp, Med Res Council Human Genet Unit, Insti Genet & Mol Med, Edinburgh EH4 2XU, Midlothian, Scotland.
    Henderson, Brian E.
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Norris Comprehens Canc Ctr, Los Angeles, CA 90033 USA.
    Haiman, Christopher A.
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Norris Comprehens Canc Ctr, Los Angeles, CA 90033 USA.
    Schumacher, Fredrick R.
    Case Western Reserve Univ, Dept Epidemiol & Biostat, Cleveland, OH 44106 USA;Univ Hosp, Seidman Canc Ctr, Cleveland, OH 44106 USA.
    Al Olama, Ali Amin
    Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Oncol, Strangeways Lab, Cambridge CB1 8RN, England;Univ Cambridge, Dept Clin Neurosci, Cambridge CB2 1TN, England.
    Benlloch, Sara
    Inst Canc Res, Div Genet & Epidemiol, London SW7 3RP, England;Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Oncol, Strangeways Lab, Cambridge CB1 8RN, England.
    Berndt, Sonja, I
    NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.
    Conti, David, V
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Norris Comprehens Canc Ctr, Los Angeles, CA 90033 USA.
    Wiklund, Fredrik
    Karolinska Inst, Dept Med Epidemiol & Biostat, S-30303 Stockholm, Sweden.
    Chanock, Stephen
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Norris Comprehens Canc Ctr, Los Angeles, CA 90033 USA.
    Gapstur, Susan
    Amer Canc Soc, Epidemiol Res Program, 250 Williams St, Atlanta, GA 30303 USA.
    Stevens, Victoria L.
    Amer Canc Soc, Epidemiol Res Program, 250 Williams St, Atlanta, GA 30303 USA.
    Tangen, Catherine M.
    Fred Hutchinson Canc Res Ctr, SWOG Stat Ctr, Seattle, WA 98109 USA.
    Batra, Jyotsna
    Queensland Univ Technol, Australian Prostate Canc Res Ctr Qld, Inst Hlth & Biomed Innovat, Brisbane, Qld 4059, Australia;Queensland Univ Technol, Sch Biomed Sci, Brisbane, Qld 4059, Australia;Translat Res Inst, Brisbane, Qld 4102, Australia.
    Clements, Judith
    Queensland Univ Technol, Australian Prostate Canc Res Ctr Qld, Inst Hlth & Biomed Innovat, Brisbane, Qld 4059, Australia;Queensland Univ Technol, Sch Biomed Sci, Brisbane, Qld 4059, Australia;Translat Res Inst, Brisbane, Qld 4102, Australia.
    Gronberg, Henrik
    Karolinska Inst, Dept Med Epidemiol & Biostat, S-30303 Stockholm, Sweden.
    Schleutker, Johanna
    Univ Turku, Inst Biomed, Dept Med Biochem & Genet, Turku 20520, Finland;Turku Univ Hosp, Dept Med Genet, Tyks Microbiol & Genet, Turku 20520, Finland.
    Albanes, Demetrius
    NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics. Karolinska Inst, Inst Environm Med, Div Nutr Epidemiol, S-17177 Stockholm, Sweden.
    West, Catharine
    Univ Manchester, Christie Hosp NHS Fdn Trust, Radiotherapy Related Res,Div Canc Sci, Manchester NIHR Biomed Res Ctr,Manchester Acad Hl, Manchester M13 9NT, Lancs, England.
    Mucci, Lorelei
    Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.
    Cancel-Tassin, Geraldine
    Tenon Hosp, CeRePP, F-75020 Paris, France;Sorbonne Univ, Tenon Hosp, GRC 5 ONCOTYPE URO, F-75970 Paris, France.
    Koutros, Stella
    NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.
    Sorensen, Karina Dalsgaard
    Aarhus Univ Hosp, Dept Mol Med, DK-8000 Aarhus, Denmark;Aarhus Univ, Dept Clin Med, DK-8000 Aarhus, Denmark.
    Grindeda, Eli Marie
    Oslo Univ Hosp, Dept Med Genet, N-0424 Oslo, Norway.
    Neal, David E.
    Univ Cambridge, Addenbrookes Hosp, Dept Oncol, Cambridge CB2 0QQ, England;Li Ka Shing Ctr, Canc Res UK Cambridge Res Inst, Cambridge CB2 0RE, England;Univ Oxford, Nuffield Dept Surg Sci, Oxford OX3 7LF, England;Univ Oxford, John Radcliffe Hosp, Fac Med Sci, Oxford OX3 9DU, England.
    Hamdy, Freddie C.
    Univ Oxford, Nuffield Dept Surg Sci, Oxford OX3 7LF, England;Univ Oxford, John Radcliffe Hosp, Fac Med Sci, Oxford OX3 9DU, England.
    Donovan, Jenny L.
    Univ Bristol, Sch Social & Community Med, Bristol BS8 2PS, Avon, England.
    Travis, Ruth C.
    Univ Oxford, Canc Epidemiol Unit, Nuffield Dept Populat Hlth, Oxford OX3 7LF, England.
    Hamilton, Robert J.
    Princess Margaret Canc Ctr, Dept Surg Oncol, Toronto, ON M5G 2M9, Canada.
    Ingles, Sue Ann
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Norris Comprehens Canc Ctr, Los Angeles, CA 90033 USA.
    Rosenstein, Barry S.
    Icahn Sch Med Mt Sinai, Dept Radiat Oncol, New York, NY 10029 USA;Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 USA.
    Lu, Yong-Jie
    Queen Mary Univ London, Ctr Mol Oncol, John Vane Sci Ctr, Barts Canc Inst, London EC1M 66Q, England.
    Giles, Graham G.
    Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic 3004, Australia;Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Melbourne, Vic 3053, Australia.
    Kibel, Adam S.
    Brigham & Womens Hosp, Div Urol Surg, Boston, MA 02115 USA.
    Vega, Ana
    IDIS, Fdn Publ Galega Med Xenorn SERGAS, CIBERER, Grp Med Xenorn, Santiago De Compostela 15782, Spain.
    Kogevinas, Manolis
    Barcelona Inst Global Hlth ISGlobal, Ctr Res Environm Epidemiol CREAL, Barcelona 60803, Spain;CIBER Epidemiol & Salud PUbl CIBERESP, Madrid 28029, Spain;IMIM Hosp Mar Res Inst, Barcelona 08003, Spain;Univ Pompeu Fabra, Barcelona 08002, Spain.
    Penney, Kathryn L.
    Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA 02115 USA.
    Park, Jong Y.
    H Lee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, Tampa, FL 33612 USA.
    Stanford, Janet L.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA;Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA.
    Cybulski, Cezary
    Pomeranian Med Univ, Int Hereditary Canc Ctr, Dept Genet & Pathol, PL-70001 Szczecin, Poland.
    Nordestgaard, Borge G.
    Univ Copenhagen, Fac Hlth & Med Sci, DK-1165 Copenhagen, Denmark;Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Dept Clin Biochem, DK-2900 Herlev, Denmark.
    Maier, Christiane
    Univ Hosp Ulm, Inst Human Genet, D-89081 Ulm, Germany.
    Kim, Jeri
    Univ Texas MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, Houston, TX 77030 USA.
    John, Esther M.
    Canc Prevent Inst Calif, Fremont, CA 94538 USA;Stanford Univ, Dept Hlth Res & Policy Epidemiol, Sch Med, Stanford, CA 94305 USA;Stanford Univ, Stanford Canc Inst, Sch Med, Stanford, CA 94305 USA.
    Teixeira, Manuel R.
    Portuguese Oncol Inst Porto, Dept Genet, P-4200072 Porto, Portugal;Univ Porto, Biomed Sci Inst ICBAS, P-4200072 Porto, Portugal.
    Neuhausen, Susan L.
    Beckman Res Inst City Hope, Dept Populat Sci, Duarte, CA 91016 USA.
    De Ruyck, Kim
    Univ Ghent, Fac Med & Hlth Sci, Basic Med Sci, B-9000 Ghent, Belgium.
    Razack, Azad
    Univ Malaya, Fac Med, Dept Surg, Kuala Lumpur 50603, Malaysia.
    Newcomb, Lisa F.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA;Univ Washington, Dept Urol, Seattle, WA 98105 USA.
    Gamulin, Marija
    Univ Hosp Ctr Zagreb, Dept Oncol, Div Med Oncol, Urogenital Unit, Zagreb 10000, Croatia.
    Kaneva, Radka
    Med Univ, Mol Med Ctr, Dept Med Chem & Biochem, Sofia 1431, Bulgaria.
    Usmani, Nawaid
    Univ Alberta, Cross Canc Inst, Dept Oncol, Edmonton, AB T6G 2R3, Canada;Cross Canc Inst, Div Radiat Oncol, Edmonton, AB T6G 1Z2, Canada.
    Claessens, Frank
    Katholieke Univ Leuven, Mol Endocrinol Lab, Dept Cellular & Mol Med, B-3000 Leuven, Belgium.
    Townsend, Paul A.
    Univ Manchester, St Marys Hosp, Manchester Acad Hlth Sci Ctr, Manchester Canc Res Ctr, Manchester M13 9WL, Lancs, England.
    Gago-Dominguez, Manuela
    Inst Invest Santiago, Fdn Publ Galega Med Xenom, Grp Med Xenom, Santiago De Compostela 15706, Spain;Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA.
    Roobol, Monique J.
    Erasmus MC, Dept Urol, NL-3015 Rotterdam, Netherlands.
    Menegaux, Florence
    Univ Paris Sud, Univ Paris Saclay, Ctr Res Epidemiol & Populat Hlth CESP, INSERM, F-94805 Villejuif, France.
    Khaw, Kay-Tee
    Univ Cambridge, Clin Gerontol Unit, Cambridge CB2 2QQ, England.
    Cannon-Albright, Lisa
    Univ Utah, Dept Med, Div Genet Epidemiol, Sch Med, Salt Lake City, UT 84108 USA;Vet Affairs Med Ctr, George E Wahlen Dept, Salt Lake City, UT 84148 USA.
    Pandha, Hardev
    Univ Surrey, Guildford GU2 7XH, Surrey, England.
    Thibodeau, Stephen N.
    Mayo Clin, Dept Lab Med & Pathol, Rochester, MN 55905 USA.
    Association analyses identify 31 new risk loci for colorectal cancer susceptibility2019In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 10, article id 2154Article in journal (Refereed)
    Abstract [en]

    Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, and has a strong heritable basis. We report a genome-wide association analysis of 34,627 CRC cases and 71,379 controls of European ancestry that identifies SNPs at 31 new CRC risk loci. We also identify eight independent risk SNPs at the new and previously reported European CRC loci, and a further nine CRC SNPs at loci previously only identified in Asian populations. We use in situ promoter capture Hi-C (CHi-C), gene expression, and in silico annotation methods to identify likely target genes of CRC SNPs. Whilst these new SNP associations implicate target genes that are enriched for known CRC pathways such as Wnt and BMP, they also highlight novel pathways with no prior links to colorectal tumourigenesis. These findings provide further insight into CRC susceptibility and enhance the prospects of applying genetic risk scores to personalised screening and prevention.

  • 45. Lindblad, Birgitta Ejdervik
    et al.
    Håkansson, Niclas
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Metabolic syndrome and some of its components in relation to risk of cataract extraction.: A prospective cohort study of men2018In: Acta Ophthalmologica, ISSN 1755-375X, E-ISSN 1755-3768Article in journal (Refereed)
    Abstract [en]

    PURPOSE: To evaluate the relationship between metabolic syndrome and some of its components with the incidence of cataract extraction.

    METHODS: A population-based prospective cohort with a total of 45 049 men, aged 45-79 years, from the Cohort of Swedish Men completed in 1997 a self-administered questionnaire concerning anthropometric measurements and lifestyle factors. The men were followed from 1 January 1998 through 31 December 2012, and the cohort was matched with registers of cataract extraction. The main outcome measure was incident cases of age-related cataract extraction.

    RESULTS: Over the 15-years of follow-up, 7573 incident cases of cataract extraction were identified. After controlling for potential confounders, the association between single components of metabolic syndrome, abdominal adiposity, diabetes and hypertension and risk of cataract extraction was rate ratio (RR): 1.04; 95% confidence interval (CI): 0.99-1.10, RR: 1.77; 95% CI: 1.64-1.92 and RR: 1.06; 95% CI 1.00-1.13, respectively. The risk of cataract extraction increased with increasing numbers of metabolic syndrome components (p < 0.0001). Men aged 65 years or younger at baseline with all three components of the metabolic syndrome had a relative risk of 2.43 (95% CI: 1.95-3.01) for cataract extraction.

    CONCLUSION: In this cohort of middle-aged and elderly men, metabolic syndrome with the combination of abdominal adiposity, diabetes and hypertension was associated with an increased risk for cataract extraction, especially among men aged 65 years or younger. These findings put emphasis on the importance of weight control and healthy lifestyle behaviours in order to prevent cataract.

  • 46. Lourdudoss, Cecilia
    et al.
    Arnaud, Laurent
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    van Vollenhoven, Ronald F
    Di Giuseppe, Daniela
    Long-Term Dietary Changes after Diagnosis of Rheumatoid Arthritis in Swedish Women: Data from a Population-Based Cohort2018In: International Journal of Rheumatology, ISSN 1687-9260, E-ISSN 1687-9279, Vol. 2018, article id 9152480Article in journal (Refereed)
    Abstract [en]

    Objective: To investigate long-term dietary changes after rheumatoid arthritis (RA) diagnosis in Swedish women, compared to women without RA.

    Methods: This study included 21,602 women from the Swedish Mammography Cohort (SMC), who completed dietary questionnaires in 1997 and 2009. Between 1997 and 2009, 191 women were diagnosed with RA. Dietary changes after RA diagnosis were analyzed based on intake of 82 food items. Statistical analysis included linear mixed models.

    Results: Women with RA, compared to women without RA, had significantly lower intake (mean servings per week) of animal products such as black pudding, egg, kidney, and liver paste (2.94±2.73 versus 2.45±1.82, p=0.010) and dairy products (35.14±20.02 versus 28.42±16.10, p=0.040) in 1997 and of cereals and grains (31.01±15.54 versus 28.00±14.98, p=0.009) in 2009. However, multivariable adjusted changes in dietary intake from 1997 to 2009 did not show any significant difference in intake. Nevertheless, women without RA increased their intake of whole wheat bread, wheat/oat bran, and rice more than women with RA.

    Conclusion: Women who had been diagnosed with RA had similar dietary patterns over time as the general population; these women did not remarkably change their diet over time due to their disease. Dietary recommendations for RA patients are needed.

  • 47. Lourdudoss, Cecilia
    et al.
    Di Giuseppe, Daniela
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Westerlind, Helga
    Klareskog, Lars
    Alfredsson, Lars
    van Vollenhoven, Ronald F
    Lampa, Jon
    Dietary Intake of Polyunsaturated Fatty Acids and Pain in Spite of Inflammatory Control Among Methotrexate-Treated Early Rheumatoid Arthritis Patients.2018In: Arthritis care & research, ISSN 2151-464X, E-ISSN 2151-4658, Vol. 70, no 2, p. 205-212Article in journal (Refereed)
    Abstract [en]

    OBJECTIVE: To investigate potential associations between dietary intake of polyunsaturated fatty acids (FAs) and pain patterns in early rheumatoid arthritis (RA) patients after 3 months of methotrexate (MTX) treatment.

    METHODS: We included 591 early RA patients with MTX monotherapy from a population-based prospective case-control study, the Epidemiological Investigation of Rheumatoid Arthritis. Dietary data on polyunsaturated FAs (food frequency questionnaires) were linked with data on unacceptable pain (visual analog scale [VAS] >40 mm), noninflammatory/refractory pain (VAS >40 mm and C-reactive protein [CRP] level <10 mg/liter), and inflammatory pain (VAS >40 mm and CRP level >10 mg/liter) after 3 months. Statistical analysis included logistic regression.

    RESULTS: After 3 months of MTX treatment, 125 patients (21.2%) had unacceptable pain, of which 92 patients had refractory pain, and 33 patients had inflammatory pain. Omega-3 FA intake was inversely associated with unacceptable pain and refractory pain (odds ratio [OR] 0.57 [95% confidence interval (95% CI) 0.35-0.95] and OR 0.47 [95% CI 0.26-0.84], respectively). The omega-6:omega-3 FA ratio, but not omega-6 FA alone, was directly associated with unacceptable pain and refractory pain (OR 1.70 [95% CI 1.03-2.82] and OR 2.33 [95% CI 1.28-4.24], respectively). Furthermore, polyunsaturated FAs were not associated with either inflammatory pain or CRP level and erythrocyte sedimentation rate at followup. Omega-3 FA supplementation was not associated with any pain patterns.

    CONCLUSION: Omega-3 FA was inversely associated with, and the omega-6:omega-3 FA ratio was directly associated with, unacceptable and refractory pain, but not with inflammatory pain or systemic inflammation. The inverse association between omega-3 FA and refractory pain may have a role in pain suppression in RA.

  • 48. Lourdudoss, Cecilia
    et al.
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Nise, Lena
    Alfredsson, Lars
    Vollenhoven, Ronald van
    Are dietary vitamin D, omega-3 fatty acids and folate associated with treatment results in patients with early rheumatoid arthritis? Data from a Swedish population-based prospective study.2017In: BMJ Open, ISSN 2044-6055, E-ISSN 2044-6055, Vol. 7, no 6, article id e016154Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Dietary intake of vitamin D and omega-3 fatty acids (FA) may be associated with superior response to antirheumatic treatments. In addition, dietary folate intake may be associated with worse response to methotrexate (MTX). The aim of this study was to investigate the association between dietary vitamin D, omega-3 FA, folate and treatment results of disease-modifying antirheumatic drugs (DMARDs) in patients with rheumatoid arthritis (RA).

    METHODS: This prospective study was based on data from the Epidemiological Investigation of Rheumatoid Arthritis (EIRA) study, and included 727 patients with early RA from 10 hospitals in Sweden. Data on dietary vitamin D, omega-3 FA and folate intake based on food frequency questionnaires were linked with data on European League Against Rheumatism (EULAR) response after 3 months of DMARD treatment. Associations between vitamin D, omega-3 FA, folate and EULAR response were analysed with logistic regression adjusted for potential confounders.

    RESULTS: The majority of patients (89.9%) were initially treated with MTX monotherapy and more than half (56.9%) with glucocorticoids. Vitamin D and omega-3 FA were associated with good EULAR response (OR 1.80 (95% CI 1.14 to 2.83) and OR 1.60 (95% CI 1.02 to 2.53), respectively). Folate was not significantly associated with EULAR response (OR 1.20 (95% CI 0.75 to 1.91)). Similar results were seen in a subgroup of patients who were initially treated with MTX monotherapy at baseline.

    CONCLUSIONS: Higher intake of dietary vitamin D and omega-3 FA during the year preceding DMARD initiation may be associated with better treatment results in patients with early RA. Dietary folate intake was not associated with worse or better response to treatment, especially to MTX. Our results suggest that some nutrients may be associated with enhanced treatment results of DMARDs.

  • 49. Lu, Yingchang
    et al.
    Beeghly-Fadiel, Alicia
    Wu, Lang
    Guo, Xingyi
    Li, Bingshan
    Schildkraut, Joellen M
    Im, Hae Kyung
    Chen, Yian A
    Permuth, Jennifer B
    Reid, Brett M
    Teer, Jamie K
    Moysich, Kirsten B
    Andrulis, Irene L
    Anton-Culver, Hoda
    Arun, Banu K
    Bandera, Elisa V
    Barkardottir, Rosa B
    Barnes, Daniel R
    Benitez, Javier
    Bjorge, Line
    Brenton, James
    Butzow, Ralf
    Caldes, Trinidad
    Caligo, Maria A
    Campbell, Ian
    Chang-Claude, Jenny
    Claes, Kathleen B M
    Couch, Fergus J
    Cramer, Daniel W
    Daly, Mary B
    deFazio, Anna
    Dennis, Joe
    Diez, Orland
    Domchek, Susan M
    Dörk, Thilo
    Easton, Douglas F
    Eccles, Diana M
    Fasching, Peter A
    Fortner, Renée T
    Fountzilas, George
    Friedman, Eitan
    Ganz, Patricia A
    Garber, Judy
    Giles, Graham G
    Godwin, Andrew K
    Goldgar, David E
    Goodman, Marc T
    Greene, Mark H
    Gronwald, Jacek
    Hamann, Ute
    Heitz, Florian
    Hildebrandt, Michelle A T
    Høgdall, Claus K
    Hollestelle, Antoinette
    Hulick, Peter J
    Huntsman, David G
    Imyanitov, Evgeny N
    Isaacs, Claudine
    Jakubowska, Anna
    James, Paul
    Karlan, Beth Y
    Kelemen, Linda E
    Kiemeney, Lambertus A
    Kjaer, Susanne K
    Kwong, Ava
    Le, Nhu D
    Leslie, Goska
    Lesueur, Fabienne
    Levine, Douglas A
    Mattiello, Amalia
    May, Taymaa
    McGuffog, Lesley
    McNeish, Iain A
    Merritt, Melissa A
    Modugno, Francesmary
    Montagna, Marco
    Neuhausen, Susan L
    Nevanlinna, Heli
    Nielsen, Finn C
    Nikitina-Zake, Liene
    Nussbaum, Robert L
    Offit, Kenneth
    Olah, Edith
    Olopade, Olufunmilayo I
    Olson, Sara H
    Olsson, Håkan
    Osorio, Ana
    Park, Sue K
    Parsons, Michael T
    Peeters, Petra H M
    Pejovic, Tanja
    Peterlongo, Paolo
    Phelan, Catherine M
    Pujana, Miquel Angel
    Ramus, Susan J
    Rennert, Gad
    Risch, Harvey
    Rodriguez, Gustavo C
    Rodríguez-Antona, Cristina
    Romieu, Isabelle
    Rookus, Matti A
    Rossing, Mary Anne
    Rzepecka, Iwona K
    Sandler, Dale P
    Schmutzler, Rita K
    Setiawan, Veronica W
    Sharma, Priyanka
    Sieh, Weiva
    Simard, Jacques
    Singer, Christian F
    Song, Honglin
    Southey, Melissa C
    Spurdle, Amanda B
    Sutphen, Rebecca
    Swerdlow, Anthony J
    Teixeira, Manuel R
    Teo, Soo H
    Thomassen, Mads
    Tischkowitz, Marc
    Toland, Amanda E
    Trichopoulou, Antonia
    Tung, Nadine
    Tworoger, Shelley S
    van Rensburg, Elizabeth J
    Vanderstichele, Adriaan
    Vega, Ana
    Edwards, Digna Velez
    Webb, Penelope M
    Weitzel, Jeffrey N
    Wentzensen, Nicolas
    White, Emily
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Wu, Anna H
    Yannoukakos, Drakoulis
    Zorn, Kristin K
    Gayther, Simon A
    Antoniou, Antonis C
    Berchuck, Andrew
    Goode, Ellen L
    Chenevix-Trench, Georgia
    Sellers, Thomas A
    Pharoah, Paul D P
    Zheng, Wei
    Long, Jirong
    A Transcriptome-Wide Association Study Among 97,898 Women to Identify Candidate Susceptibility Genes for Epithelial Ovarian Cancer Risk.2018In: Cancer Research, ISSN 0008-5472, E-ISSN 1538-7445, Vol. 78, no 18, p. 5419-5430Article in journal (Refereed)
    Abstract [en]

    .

    Abstract

    Large-scale genome-wide association studies (GWAS) have identified approximately 35 loci associated with epithelial ovarian cancer (EOC) risk. The majority of GWAS-identified disease susceptibility variants are located in noncoding regions, and causal genes underlying these associations remain largely unknown. Here, we performed a transcriptome-wide association study to search for novel genetic loci and plausible causal genes at known GWAS loci. We used RNA sequencing data (68 normal ovarian tissue samples from 68 individuals and 6,124 cross-tissue samples from 369 individuals) and high-density genotyping data from European descendants of the Genotype-Tissue Expression (GTEx V6) project to build ovarian and cross-tissue models of genetically regulated expression using elastic net methods. We evaluated 17,121 genes for their cis-predicted gene expression in relation to EOC risk using summary statistics data from GWAS of 97,898 women, including 29,396 EOC cases. With a Bonferroni-corrected significance level of P < 2.2 × 10−6, we identified 35 genes, including FZD4 at 11q14.2 (Z = 5.08, P = 3.83 × 10−7, the cross-tissue model; 1 Mb away from any GWAS-identified EOC risk variant), a potential novel locus for EOC risk. All other 34 significantly associated genes were located within 1 Mb of known GWAS-identified loci, including 23 genes at 6 loci not previously linked to EOC risk. Upon conditioning on nearby known EOC GWAS-identified variants, the associations for 31 genes disappeared and three genes remained (P < 1.47 × 10−3). These data identify one novel locus (FZD4) and 34 genes at 13 known EOC risk loci associated with EOC risk, providing new insights into EOC carcinogenesis.

    Significance: Transcriptomic analysis of a large cohort confirms earlier GWAS loci and reveals FZD4 as a novel locus associated with EOC risk. Cancer Res; 78(18); 5419–30. ©2018 AACR.

  • 50. Machiela, Mitchell J
    et al.
    Hofmann, Jonathan N
    Carreras-Torres, Robert
    Brown, Kevin M
    Johansson, Mattias
    Wang, Zhaoming
    Foll, Matthieu
    Li, Peng
    Rothman, Nathaniel
    Savage, Sharon A
    Gaborieau, Valerie
    McKay, James D
    Ye, Yuanqing
    Henrion, Marc
    Bruinsma, Fiona
    Jordan, Susan
    Severi, Gianluca
    Hveem, Kristian
    Vatten, Lars J
    Fletcher, Tony
    Koppova, Kvetoslava
    Larsson, Susanna C
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Banks, Rosamonde E
    Selby, Peter J
    Easton, Douglas F
    Pharoah, Paul
    Andreotti, Gabriella
    Freeman, Laura E Beane
    Koutros, Stella
    Albanes, Demetrius
    Mannisto, Satu
    Weinstein, Stephanie
    Clark, Peter E
    Edwards, Todd E
    Lipworth, Loren
    Gapstur, Susan M
    Stevens, Victoria L
    Carol, Hallie
    Freedman, Matthew L
    Pomerantz, Mark M
    Cho, Eunyoung
    Kraft, Peter
    Preston, Mark A
    Wilson, Kathryn M
    Gaziano, J Michael
    Sesso, Howard S
    Black, Amanda
    Freedman, Neal D
    Huang, Wen-Yi
    Anema, John G
    Kahnoski, Richard J
    Lane, Brian R
    Noyes, Sabrina L
    Petillo, David
    Colli, Leandro M
    Sampson, Joshua N
    Besse, Celine
    Blanche, Helene
    Boland, Anne
    Burdette, Laurie
    Prokhortchouk, Egor
    Skryabin, Konstantin G
    Yeager, Meredith
    Mijuskovic, Mirjana
    Ognjanovic, Miodrag
    Foretova, Lenka
    Holcatova, Ivana
    Janout, Vladimir
    Mates, Dana
    Mukeriya, Anush
    Rascu, Stefan
    Zaridze, David
    Bencko, Vladimir
    Cybulski, Cezary
    Fabianova, Eleonora
    Jinga, Viorel
    Lissowska, Jolanta
    Lubinski, Jan
    Navratilova, Marie
    Rudnai, Peter
    Szeszenia-Dabrowska, Neonila
    Benhamou, Simone
    Cancel-Tassin, Geraldine
    Cussenot, Olivier
    Bueno-de-Mesquita, H B As
    Canzian, Federico
    Duell, Eric J
    Ljungberg, Börje
    Sitaram, Raviprakash T
    Peters, Ulrike
    White, Emily
    Anderson, Garnet L
    Johnson, Lisa
    Luo, Juhua
    Buring, Julie
    Lee, I-Min
    Chow, Wong-Ho
    Moore, Lee E
    Wood, Christopher
    Eisen, Timothy
    Larkin, James
    Choueiri, Toni K
    Lathrop, G Mark
    Teh, Bin Tean
    Deleuze, Jean-Francois
    Wu, Xifeng
    Houlston, Richard S
    Brennan, Paul
    Chanock, Stephen J
    Scelo, Ghislaine
    Purdue, Mark P
    Corrigendum re "Genetic Variants Related to Longer Telomere Length are Associated with Increased Risk of Renal Cell Carcinoma": [Eur Urol 2017;72:747-542018In: European Urology, ISSN 0302-2838, E-ISSN 1873-7560, Vol. 74, no 3, p. e85-e86, article id S0302-2838(18)30366-XArticle in journal (Refereed)
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