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  • 1.
    Abdel-Rehim, Mohamed
    Karlstads universitet, Fakulteten för teknik- och naturvetenskap, Avdelningen för kemi och biomedicinsk vetenskap. AstraZeneca R&D Sodertalje, Global DMPK, Sodertalje, Sweden.;Karlstad Univ, Fac Sci & Technol, Dept Chem & Biomed Sci, Karlstad, Sweden..
    On-Line Whole Blood Analysis Using Microextraction by Packed Sorbent and LC-MS-MS2011Inngår i: LC GC North America, ISSN 1527-5949, E-ISSN 1939-1889, Vol. 29, nr 7, s. 612-618Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Microextraction by packed sorbent (MEPS) is a new technique for sample preparation that can be connected on-line with liquid chromatography (LC) or gas chromatography (GC) systems without any modifications. This article describes the use of MEPS in clinical and preclinical studies to quantify different drugs in whole blood samples. MEPS was used to determine cyclophosphamide in mouse blood from preclinical g studies using 20 mu L of blood samples. The interday accuracies and 0 precisions ranged from 107-109% and from 2.0-7.0%, respectively. The determination of four immunosuppressive drugs in human blood by MEPS and liquid chromatography-mass spectrometry (LC-MS) is described. The method showed a good selectivity and sensitivity. The calibration curves for everolimus, sirolimus, and tacrolimus ranged from 0.5 to 50 ng/mL and for cyclosporine from 3.0 to 1500 ng/mL. Intraday precisions for the studied immunosuppressive drugs were 2.0-11.7% and interday precision ranged from 5.1 to 13.7% (CV).

  • 2. Breadmore, Michael C.
    et al.
    Sänger van de Griend, Cari E.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för läkemedelskemi, Avdelningen för analytisk farmaceutisk kemi.
    In-capillary sample concentration in CE2014Inngår i: LC GC North America, ISSN 1527-5949, E-ISSN 1939-1889, Vol. 32, nr 3, s. 174-186Artikkel i tidsskrift (Fagfellevurdert)
  • 3.
    Euerby, Melvin R.
    et al.
    Hichrom Ltd, Reading, Berks, England.;Univ Strathclyde, Glasgow, Lanark, Scotland.;Open Univ, Milton Keynes, Bucks, England..
    Fever, Mark
    Hichrom Ltd, Reading, Berks, England..
    Hulse, Jennifer
    Hichrom Ltd, Reading, Berks, England..
    James, Matthew
    Hichrom Ltd, Reading, Berks, England..
    Petersson, Patrik
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - BMC. Novo Nordisk AS, Bagsvaerd, Denmark..
    Pipe, Cohn
    Hichrom Ltd, Reading, Berks, England..
    Maximization of Selectivity in Reversed-Phase Liquid Chromatographic Method Development Strategies2017Inngår i: LC GC North America, ISSN 1527-5949, E-ISSN 1939-1889, Vol. 35, nr 4, s. 258-272Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The selectivity of different combinations.of organic modifiers, pH, and types of reversed-phase liquid chromatography (LC) materials has been characterized using Tanaka column characterization, linear solvent energy relationships (LSER), and selectivity correlations. The three characterization techniques highlighted the potential complementary selectivity of these phases and conditions as well as the type and dominancy of some of the retention mechanisms involved. Subsequently, selectivity differences were proven to be valid in the practical separation of acids, bases, and neutral analytes. This paper aims to help chromatographers to produce highly efficient method development strategies for reversed phase LC separations in a relatively short time frame.

  • 4.
    Haglund, Peter
    et al.
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
    Spinnel, Erik
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
    A Modular Approach to Pressurized Liquid Extraction with In-Cell Cleanup2010Inngår i: LC GC North America, ISSN 1527-5949, E-ISSN 1939-1889, Vol. 28, nr 7, s. 544-+Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    A new concept for the extraction of solid samples has been developed. The popular pressurized liquid extraction (PLE) technique has been modified so that the extraction cell can be divided, which greatly increases the flexibility and versatility of this technique. The system uses simple adapters to couple commercially available extraction cells, which can be loaded with either sample or adsorbents. These segmented extraction cells make it possible to selectively retain analytes or matrix to achieve simultaneous extraction and cleanup or fractionation. The ultimate aim is to perform simultaneous extraction and cleanup and obtain a purified extract that is ready for instrumental analysis, all in line with current trends in analytical chemistry to automate and streamline the analytical procedures to reduce the analysis costs, solvent consumption, and manual labor, and increase the quality of analysis. Selected modes of operations are presented and a few recent environmental applications of modular PLE are reviewed.

  • 5.
    Haglund, Peter
    et al.
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
    Spinnel, Erik
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
    A Modular Approach to Pressurized Liquid Extraction with In-Cell Cleanup2011Inngår i: LC GC North America, ISSN 1527-5949, E-ISSN 1939-1889, nr Suppl., s. 66-72Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    A new concept for the extraction of solid samples has been developed. The popular pressurized liquid extraction (PLE) technique has been modified so that the extraction cell can be divided, which greatly increases the flexibility and versatility of this technique. The system uses simple adapters to couple commercially available extraction cells, which can be loaded with either sample or adsorbents. These segmented extraction cells make it possible to selectively retain analytes or matrix to achieve simultaneous extraction and cleanup or fractionation. The ultimate aim is to perform simultaneous extraction and cleanup and obtain a purified extract that is ready for instrumental analysis, all in line with current trends in analytical chemistry to automate and streamline the analytical procedures to reduce the analysis costs, solvent consumption, and manual labor, and increase the quality of analysis. Selected modes of operations are presented and a few recent environmental applications of modular PLE are reviewed.

  • 6.
    Nygren, Heli
    et al.
    VTT Technical Research Centre of Finland, Espoo, Finland.
    Pöhö, Päivi
    VTT Technical Research Centre of Finland, Espoo, Finland.
    Seppänen-Laakso, Tuulikki
    VTT Technical Research Centre of Finland, Espoo, Finland.
    Lahtinen, Ulla
    VTT Technical Research Centre of Finland, Espoo, Finland.
    Oresic, Matej
    VTT Technical Research Centre of Finland, Espoo, Finland.
    Hyötyläinen, Tuulia
    VTT Technical Research Centre of Finland, Espoo, Finland.
    Ultrahigh-performance liquid chromatography-mass spectrometry in Lipidomics2014Inngår i: LC GC North America, ISSN 1527-5949, E-ISSN 1939-1889, Vol. 32, nr 4, s. 286-293Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    An analytical method for the global profiling of molecular lipids in biological samples, with particular emphasis on the plasmalogen lipids, is described. The global profiling method is based on ultrahigh-performance liquid chromatography combined with quadrupole time-of-flight-mass spectrometry (UHPLC-QTOE-MS). The profiling approach is complemented by UHPLC-LTQ-Orbitrap mass spectrometry in MSn mode for de novo lipid identification.

  • 7.
    Saenger-van de Griend, Carl
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för farmaceutisk kemi.
    Majors, Ronald E.
    Revival of Capillary Electrophoresis Techniques in the Pharmaceutical Industry2012Inngår i: LC GC North America, ISSN 1527-5949, E-ISSN 1939-1889, Vol. 30, nr 11, s. 954-+Artikkel i tidsskrift (Annet vitenskapelig)
  • 8.
    Sänger - van de Griend, Cari
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för läkemedelskemi, Avdelningen för analytisk farmaceutisk kemi.
    Revival of Capillary Electrophoretic Techniques in the Pharmaceutical Industry2012Inngår i: LC GC North America, ISSN 1527-5949, E-ISSN 1939-1889, Vol. 30, nr 11, s. 954-971Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The article focuses on the integration of capillary electrophoresis (CE) techniques in the biopharmaceutical industry. It states that CE has been used by biotech and pharmaceutical industry in all phases of drug development. The article also discusses practical aspects of CE capillary, the use of CE as chiral separation tool, and types of CE such as capillary electrochromatography. INSETS: Capillary Electrophoresis;Electrophoresis in a Capillary: The Electroosmotic Flow.

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