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  • 1.
    Högberg, Lotta
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Pediatrics. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center of Paediatrics and Gynaecology and Obstetrics, Department of Paediatrics in Norrköping.
    Stenhammar, Lars
    Linköping University, Department of Clinical and Experimental Medicine, Pediatrics. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center of Paediatrics and Gynaecology and Obstetrics, Department of Paediatrics in Norrköping.
    Diagnosis criteria in young children2009In: Nature Reviews Gastroenterology & Hepatology, ISSN 1759-5045, E-ISSN 1759-5053, Vol. 6, no 8, p. 447-448Article in journal (Other academic)
    Abstract [en]

    n/a

  • 2.
    Högberg, Lotta
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Pediatrics. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center of Paediatrics and Gynaecology and Obstetrics, Department of Paediatrics in Norrköping.
    Stenhammar, Lars
    Linköping University, Department of Clinical and Experimental Medicine, Pediatrics. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center of Paediatrics and Gynaecology and Obstetrics, Department of Paediatrics in Norrköping.
    Pediatric celiac disease-is a diagnostic biopsy necessary?2012In: Nature Reviews Gastroenterology & Hepatology, ISSN 1759-5045, E-ISSN 1759-5053, Vol. 9, no 3, p. 127-128Article in journal (Other academic)
    Abstract [en]

    A small-bowel biopsy is currently required in the diagnosis of celiac disease in children. The European Society for Pediatric Gastroenterology, Hepatology and Nutrition has now presented new guidelines for the diagnosis of celiac disease, which indicate that small-bowel biopsy could be avoided in certain cases.

  • 3.
    Keller, Jutta
    et al.
    Acad Hosp Univ Hamburg, Israelit Hosp, Orchideenstieg 14, D-22297 Hamburg, Germany.
    Bassotti, Gabrio
    Univ Perugia, Piazza Univ 1, I-06121 Perugia, Italy.
    Clarke, John
    Stanford Univ, 900 Blake Wilbur Dr, Palo Alto, CA 94304 USA.
    Dinning, Phil
    Flinders Med Ctr, GPO Box 2100, Adelaide, SA 5001, Australia.
    Fox, Mark
    Univ Hosp Zurich, Ramistr 100, CH-8091 Zurich, Switzerland;St Clara Hosp, Kleinriehenstr 30, CH-4058 Basel, Switzerland.
    Grover, Madhusudan
    Mayo Clin, 200 First St SW, Rochester, MN 55902 USA.
    Hellström, Per M.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Gastroenterology/Hepatology.
    Ke, Meiyun
    Beijing Union Med Coll Hosp, 1 Shuaifuyuan Wangfujing Dongcheng Dist, Beijing 100730, Peoples R China.
    Layer, Peter
    Acad Hosp Univ Hamburg, Israelit Hosp, Orchideenstieg 14, D-22297 Hamburg, Germany.
    Malagelada, Carolina
    Univ Barcelona, Passeig Vall dHebron 119-129, Barcelona 08035, Spain.
    Parkman, Henry P.
    Temple Univ Hosp & Med Sch, 3401 N Broad St, Philadelphia, PA 19140 USA.
    Scott, S. Mark
    Queen Mary Univ London, Wingate Inst, 26 Ashfield St, London E1 2AJ, England.
    Tack, Jan
    Univ Leuven, Univ Hosp Gasthuisberg, Herestr 49, B-3000 Leuven, Belgium.
    Simren, Magnus
    Univ Gothenburg, Sahlgrenska Acad, Bla Straket 5, S-41345 Gothenburg, Sweden.
    Tornblom, Hans
    Univ Gothenburg, Sahlgrenska Acad, Bla Straket 5, S-41345 Gothenburg, Sweden.
    Camilleri, Michael
    Mayo Clin, 200 First St SW, Rochester, MN 55902 USA.
    Advances in the diagnosis and classification of gastric and intestinal motility disorders2018In: Nature Reviews. Gastroenterology & Hepatology, ISSN 1759-5045, E-ISSN 1759-5053, Vol. 15, no 5, p. 291-308Article in journal (Refereed)
    Abstract [en]

    Disturbances of gastric, intestinal and colonic motor and sensory functions affect a large proportion of the population worldwide, impair quality of life and cause considerable health-care costs. Assessment of gastrointestinal motility in these patients can serve to establish diagnosis and to guide therapy. Major advances in diagnostic techniques during the past 5-10 years have led to this update about indications for and selection and performance of currently available tests. As symptoms have poor concordance with gastrointestinal motor dysfunction, clinical motility testing is indicated in patients in whom there is no evidence of causative mucosal or structural diseases such as inflammatory or malignant disease. Transit tests using radiopaque markers, scintigraphy, breath tests and wireless motility capsules are noninvasive. Other tests of gastrointestinal contractility or sensation usually require intubation, typically represent second-line investigations limited to patients with severe symptoms and are performed at only specialized centres. This Consensus Statement details recommended tests as well as useful clinical alternatives for investigation of gastric, small bowel and colonic motility. The article provides recommendations on how to classify gastrointestinal motor disorders on the basis of test results and describes how test results guide treatment decisions.

  • 4.
    Mardinoglu, Adil
    et al.
    KTH, Centres, Science for Life Laboratory, SciLifeLab. Chalmers Univ Technol, Dept Biol & Biol Engn, Gothenburg, Sweden..
    Boren, Jan
    Univ Gothenburg, Dept Mol & Clin Med, Gothenburg, Sweden.;Sahlgrens Univ Hosp, Gothenburg, Sweden..
    Smith, Ulf
    Univ Gothenburg, Dept Mol & Clin Med, Gothenburg, Sweden.;Sahlgrens Univ Hosp, Gothenburg, Sweden..
    Uhlén, Mathias
    KTH, Centres, Science for Life Laboratory, SciLifeLab.
    Nielsen, Jens
    KTH, Centres, Science for Life Laboratory, SciLifeLab. Chalmers Univ Technol, Dept Biol & Biol Engn, Gothenburg, Sweden..
    Systems biology in hepatology: approaches and applications2018In: Nature Reviews. Gastroenterology & Hepatology, ISSN 1759-5045, E-ISSN 1759-5053, Vol. 15, no 6, p. 365-377Article, review/survey (Refereed)
    Abstract [en]

    Detailed insights into the biological functions of the liver and an understanding of its crosstalk with other human tissues and the gut microbiota can be used to develop novel strategies for the prevention and treatment of liver-associated diseases, including fatty liver disease, cirrhosis, hepatocellular carcinoma and type 2 diabetes mellitus. Biological network models, including metabolic, transcriptional regulatory, protein-protein interaction, signalling and co-expression networks, can provide a scaffold for studying the biological pathways operating in the liver in connection with disease development in a systematic manner. Here, we review studies in which biological network models were used to integrate multiomics data to advance our understanding of the pathophysiological responses of complex liver diseases. We also discuss how this mechanistic approach can contribute to the discovery of potential biomarkers and novel drug targets, which might lead to the design of targeted and improved treatment strategies. Finally, we present a roadmap for the successful integration of models of the liver and other human tissues with the gut microbiota to simulate whole-body metabolic functions in health and disease.

  • 5. Mardinoglu, Adil
    et al.
    Uhlén, Mathias
    KTH, School of Biotechnology (BIO), Proteomics and Nanobiotechnology. KTH, Centres, Science for Life Laboratory, SciLifeLab.
    Phenotypic and genetic variance: a systems approach to the liver2016In: Nature Reviews Gastroenterology & Hepatology, ISSN 1759-5045, E-ISSN 1759-5053, Vol. 13, no 8, p. 439-440Article in journal (Other academic)
1 - 5 of 5
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