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  • 1. Akkaya, Munir
    et al.
    Bansal, Abhisheka
    Sheehan, Patrick W.
    Pena, Mirna
    Molina-Cruz, Alvaro
    Orchard, Lindsey M.
    Cimperman, Clare K.
    Qi, Chen-Feng
    Ross, Philipp
    Yazew, Takele
    Sturdevant, Daniel
    Anzick, Sarah L.
    Thiruvengadam, Girija
    Otto, Thomas Dan
    Billker, Oliver
    Umeå universitet, Medicinska fakulteten, Molekylär Infektionsmedicin, Sverige (MIMS). Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet).
    Llinas, Manuel
    Miller, Louis H.
    Pierce, Susan K.
    A single-nucleotide polymorphism in a Plasmodium berghei ApiAP2 transcription factor alters the development of host immunity2020Ingår i: Science Advances, E-ISSN 2375-2548, Vol. 6, nr 6, artikel-id eaaw6957Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The acquisition of malaria immunity is both remarkably slow and unpredictable. At present, we know little about the malaria parasite genes that influence the host's ability to mount a protective immune response. Here, we show that a single-nucleotide polymorphism (SNP) resulting in a single amino acid change (S to F) in an ApiAP2 transcription factor in the rodent malaria parasite Plasmodium berghei (Pb) NK65 allowed infected mice to mount a T helper cell 1 (T(H)1)-type immune response that controlled subsequent infections. As compared to PbNK65(S), PbNK65(F) parasites differentially expressed 46 genes, most of which are predicted to play roles in immune evasion. PbNK65(F) infections resulted in an early interferon-gamma response and a later expansion of germinal centers, resulting in high levels of infected red blood cell-specific T(H)1-type immunoglobulin G2b (IgG2b) and IgG2c antibodies. Thus, the Pb ApiAP2 transcription factor functions as a critical parasite virulence factor in malaria infections.

    Ladda ner fulltext (pdf)
    fulltext
  • 2.
    Bielecki, Johan
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Molekylär biofysik.
    Hantke, Max F.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Molekylär biofysik.
    Daurer, Benedikt J.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Molekylär biofysik.
    Reddy, Hemanth K. N.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Molekylär biofysik.
    Hasse, Dirk
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Molekylär biofysik.
    Larsson, Daniel S. D.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Molekylär biofysik.
    Gunn, Laura H.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Molekylär biofysik.
    Svenda, Martin
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Molekylär biofysik.
    Munke, Anna
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Molekylär biofysik.
    Sellberg, Jonas A.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Molekylär biofysik.
    Flueckiger, Leonie
    Pietrini, Alberto
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Molekylär biofysik.
    Nettelblad, Carl
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Molekylär biofysik.
    Lundholm, Ida
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Molekylär biofysik.
    Carlsson, Gunilla
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Molekylär biofysik.
    Okamoto, Kenta
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Molekylär biofysik.
    Timneanu, Nicusor
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi, Molekyl- och kondenserade materiens fysik.
    Westphal, Daniel
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Molekylär biofysik.
    Kulyk, Olena
    Higashiura, Akifumi
    van der Schot, Gijs
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Molekylär biofysik.
    Loh, Ne-Te Duane
    Wysong, Taylor E.
    Bostedt, Christoph
    Gorkhover, Tais
    Iwan, Bianca
    Seibert, M. Marvin
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Molekylär biofysik.
    Osipov, Timur
    Walter, Peter
    Hart, Philip
    Bucher, Maximilian
    Ulmer, Anatoli
    Ray, Dipanwita
    Carini, Gabriella
    Ferguson, Ken R.
    Andersson, Inger
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Molekylär biofysik.
    Andreasson, Jakob
    Hajdu, Janos
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Molekylär biofysik.
    Maia, Filipe R. N. C.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Molekylär biofysik.
    Electrospray sample injection for single-particle imaging with x-ray lasers2019Ingår i: Science Advances, E-ISSN 2375-2548, Vol. 5, nr 5, artikel-id eaav8801Artikel i tidskrift (Refereegranskat)
  • 3.
    Bielecki, Johan
    et al.
    Uppsala Univ, Dept Cell & Mol Biol, Lab Mol Biophys, Husargatan 3,Box 596, SE-75124 Uppsala, Sweden.;European XFEL GmbH, Holzkoppel 4, D-22869 Schenefeld, Germany..
    Svenda, Martin
    KTH, Skolan för teknikvetenskap (SCI), Tillämpad fysik, Biomedicinsk fysik och röntgenfysik. Uppsala Univ, Dept Cell & Mol Biol, Lab Mol Biophys, Husargatan 3,Box 596, SE-75124 Uppsala, Sweden.
    Sellberg, Jonas A.
    KTH, Skolan för teknikvetenskap (SCI), Tillämpad fysik, Biomedicinsk fysik och röntgenfysik. Uppsala Univ, Dept Cell & Mol Biol, Lab Mol Biophys, Husargatan 3,Box 596, SE-75124 Uppsala, Sweden.
    Maia, Filipe R. N. C.
    Uppsala Univ, Dept Cell & Mol Biol, Lab Mol Biophys, Husargatan 3,Box 596, SE-75124 Uppsala, Sweden.;Lawrence Berkeley Natl Lab, NERSC, Berkeley, CA 94720 USA..
    Electrospray sample injection for single-particle imaging with x-ray lasers2019Ingår i: Science Advances, E-ISSN 2375-2548, Vol. 5, nr 5, artikel-id eaav8801Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The possibility of imaging single proteins constitutes an exciting challenge for x-ray lasers. Despite encouraging results on large particles, imaging small particles has proven to be difficult for two reasons: not quite high enough pulse intensity from currently available x-ray lasers and, as we demonstrate here, contamination of the aerosolized molecules by nonvolatile contaminants in the solution. The amount of contamination on the sample depends on the initial droplet size during aerosolization. Here, we show that, with our electrospray injector, we can decrease the size of aerosol droplets and demonstrate virtually contaminant-free sample delivery of organelles, small virions, and proteins. The results presented here, together with the increased performance of next-generation x-ray lasers, constitute an important stepping stone toward the ultimate goal of protein structure determination from imaging at room temperature and high temporal resolution.

  • 4. Bigalke, Janna M.
    et al.
    Aibara, Shintaro
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för biokemi och biofysik. Stockholms universitet, Science for Life Laboratory (SciLifeLab).
    Roth, Robert
    Dahl, Göran
    Gordon, Euan
    Dorbéus, Sarah
    Amunts, Alexey
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för biokemi och biofysik. Stockholms universitet, Science for Life Laboratory (SciLifeLab). Karolinska Institutet, Sweden.
    Sandmark, Jenny
    Cryo-EM structure of the activated RET signaling complex reveals the importance of its cysteine-rich domain2019Ingår i: Science Advances, E-ISSN 2375-2548, Vol. 5, nr 7, artikel-id eaau4202Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Signaling through the receptor tyrosine kinase RET is essential during normal development. Both gain- and loss-of-function mutations are involved in a variety of diseases, yet the molecular details of receptor activation have remained elusive. We have reconstituted the complete extracellular region of the RET signaling complex together with Neurturin (NRTN) and GFR alpha 2 and determined its structure at 5.7-angstrom resolution by cryo-EM. The proteins form an assembly through RET-GFR alpha 2 and RET-NRTN interfaces. Two key interaction points required for RET extracellular domain binding were observed: (i) the calcium-binding site in RET that contacts GFR alpha 2 domain 3 and (ii) the RET cysteine-rich domain interaction with NRTN. The structure highlights the importance of the RET cysteine-rich domain and allows proposition of a model to explain how complex formation leads to RET receptor dimerization and its activation. This provides a framework for targeting RET activity and for further exploration of mechanisms underlying neurological diseases.

  • 5.
    Blasiak, Robert
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Stockholm Resilience Centre. The University of Tokyo, Japan.
    Jouffray, Jean-Baptiste
    Stockholms universitet, Naturvetenskapliga fakulteten, Stockholm Resilience Centre. Royal Swedish Academy of Sciences, Sweden.
    Wabnitz, Colette C. C.
    Sundström, Emma
    Stockholms universitet, Naturvetenskapliga fakulteten, Stockholm Resilience Centre.
    Österblom, Henrik
    Stockholms universitet, Naturvetenskapliga fakulteten, Stockholm Resilience Centre.
    Corporate control and global governance of marine genetic resources2018Ingår i: Science Advances, ISSN 0036-8156, E-ISSN 2375-2548, Vol. 4, nr 6, artikel-id eaar5237Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Who owns ocean biodiversity? This is an increasingly relevant question, given the legal uncertainties associated with the use of genetic resources from areas beyond national jurisdiction, which cover half of the Earth's surface. We accessed 38 million records of genetic sequences associated with patents and created a database of 12,998 sequences extracted from 862 marine species. We identified >1600 sequences from 91 species associated with deepsea and hydrothermal vent systems, reflecting commercial interest in organisms from remote ocean areas, as well as a capacity to collect and use the genes of such species. A single corporation registered 47% of all marine sequences included in gene patents, exceeding the combined share of 220 other companies (37%). Universities and their commercialization partners registered 12%. Actors located or headquartered in 10 countries registered 98% of all patent sequences, and 165 countries were unrepresented. Our findings highlight the importance of inclusive participation by all states in international negotiations and the urgency of clarifying the legal regime around access and benefit sharing of marine genetic resources. We identify a need for greater transparency regarding species provenance, transfer of patent ownership, and activities of corporations with a disproportionate influence over the patenting of marine biodiversity. We suggest that identifying these key actors is a critical step toward encouraging innovation, fostering greater equity, and promoting better ocean stewardship.

  • 6.
    Bratman, Gregory N.
    et al.
    Univ Washington, Sch Environm & Forest Sci, Seattle, WA 98195 USA;Univ Washington, Ctr Creat Conservat, Seattle, WA 98195 USA;Stanford Univ, Ctr Conservat Biol, Stanford, CA 94305 USA;Nat Capital Project, Stanford, CA 94305 USA.
    Anderson, Christopher B.
    Stanford Univ, Ctr Conservat Biol, Stanford, CA 94305 USA;Stanford Univ, Dept Biol, Stanford, CA 94305 USA.
    Berman, Marc G.
    Univ Chicago, Dept Psychol, 5848 S Univ Ave, Chicago, IL 60637 USA;Univ Chicago, Grossman Inst Neurosci Quantitat Biol & Human Beh, Chicago, IL 60637 USA.
    Cochran, Bobby
    Willamette Partnership, Portland, OR 97239 USA.
    de Vries, Sjerp
    Wageningen Univ & Res, Wageningen Environm Res, Wageningen, Netherlands.
    Flanders, Jon
    Univ Bristol, Sch Biol Sci, Bristol, Avon, England;Bat Conservat Int, Austin, TX 78746 USA.
    Folke, Carl
    Royal Swedish Acad Sci, Global Econ Dynam & Biosphere, Stockholm, Sweden;Stockholm Univ, Stockholm Resilience Ctr, Stockholm, Sweden;Royal Swedish Acad Sci, Beijer Inst, Stockholm, Sweden.
    Frumkin, Howard
    Wellcome Trust Res Labs, London, England;Univ Washington, Sch Publ Hlth, Seattle, WA 98195 USA.
    Gross, James J.
    Stanford Univ, Dept Psychol, Jordan Hall, Stanford, CA 94305 USA.
    Hartig, Terry
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Samhällsvetenskapliga fakulteten, Institutet för bostads- och urbanforskning (IBF). Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Samhällsvetenskapliga fakulteten, Institutionen för psykologi.
    Kahn, Peter H., Jr.
    Univ Washington, Sch Environm & Forest Sci, Seattle, WA 98195 USA;Univ Washington, Dept Psychol, Seattle, WA 98195 USA.
    Kuo, Ming
    Univ Illinois, Dept Nat Resources & Environm Sci, Landscape & Human Hlth Lab, Urbana, IL 61801 USA.
    Lawler, Joshua J.
    Univ Washington, Sch Environm & Forest Sci, Seattle, WA 98195 USA;Univ Washington, Ctr Creat Conservat, Seattle, WA 98195 USA.
    Levin, Phillip S.
    Univ Washington, Sch Environm & Forest Sci, Seattle, WA 98195 USA;Univ Washington, Ctr Creat Conservat, Seattle, WA 98195 USA;Nature Conservancy, Seattle, WA 98121 USA.
    Lindahl, Therese
    Royal Swedish Acad Sci, Beijer Inst, Stockholm, Sweden.
    Meyer-Lindenberg, Andreas
    Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Mannheim, Germany.
    Mitchell, Richard
    Univ Glasgow, Inst Hlth & Wellbeing, Ctr Res Environm Soc & Hlth, Glasgow, Lanark, Scotland.
    Ouyang, Zhiyun
    Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Urban & Reg Ecol, Beijing, Peoples R China.
    Roe, Jenny
    Univ Virginia, Ctr Design & Hlth, Charlottesville, VA 22904 USA.
    Scarlett, Lynn
    Nature Conservancy, Fairfax, VA 22203 USA.
    Smith, Jeffrey R.
    Stanford Univ, Ctr Conservat Biol, Stanford, CA 94305 USA;Stanford Univ, Dept Biol, Stanford, CA 94305 USA.
    van den Bosch, Matilda
    Univ British Columbia, Sch Populat & Publ Hlth, Vancouver, BC, Canada;Univ British Columbia, Dept Forest & Conservat Sci, Vancouver, BC, Canada.
    Wheeler, Benedict W.
    Univ Exeter, Coll Med & Hlth, Med Sch, Exeter, Devon, England.
    White, Mathew P.
    Univ Exeter, Coll Med & Hlth, Med Sch, Exeter, Devon, England.
    Zheng, Hua
    Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Urban & Reg Ecol, Beijing, Peoples R China.
    Daily, Gretchen C.
    Stanford Univ, Ctr Conservat Biol, Stanford, CA 94305 USA;Nat Capital Project, Stanford, CA 94305 USA;Stanford Univ, Dept Biol, Stanford, CA 94305 USA;Stanford Univ, Stanford Woods Inst, Stanford, CA 94305 USA.
    Nature and mental health: An ecosystem service perspective2019Ingår i: Science Advances, E-ISSN 2375-2548, Vol. 5, nr 7, artikel-id eaax0903Artikel, forskningsöversikt (Refereegranskat)
    Abstract [en]

    A growing body of empirical evidence is revealing the value of nature experience for mental health. With rapid urbanization and declines in human contact with nature globally, crucial decisions must be made about how to preserve and enhance opportunities for nature experience. Here, we first provide points of consensus across the natural, social, and health sciences on the impacts of nature experience on cognitive functioning, emotional well-being, and other dimensions of mental health. We then show how ecosystem service assessments can be expanded to include mental health, and provide a heuristic, conceptual model for doing so.

    Ladda ner fulltext (pdf)
    FULLTEXT01
  • 7. Bratman, Gregory N.
    et al.
    Anderson, Christopher B.
    Berman, Marc G.
    Cochran, Bobby
    de Vries, Sjerp
    Flanders, Jon
    Folke, Carl
    Stockholms universitet, Naturvetenskapliga fakulteten, Stockholm Resilience Centre. Royal Swedish Academy of Sciences, Sweden.
    Frumkin, Howard
    Gross, James J.
    Hartig, Terry
    Kahn, Peter H.
    Kuo, Ming
    Lawler, Joshua J.
    Levin, Phillip S.
    Lindahl, Therese
    Meyer-Lindenberg, Andreas
    Mitchell, Richard
    Ouyang, Zhiyun
    Roe, Jenny
    Scarlett, Lynn
    Smith, Jeffrey R.
    van den Bosch, Matilda
    Wheeler, Benedict W.
    White, Mathew P.
    Zheng, Hua
    Daily, Gretchen C.
    Nature and mental health: An ecosystem service perspective2019Ingår i: Science Advances, E-ISSN 2375-2548, Vol. 5, nr 7, artikel-id eaax0903Artikel, forskningsöversikt (Refereegranskat)
    Abstract [en]

    A growing body of empirical evidence is revealing the value of nature experience for mental health. With rapid urbanization and declines in human contact with nature globally, crucial decisions must be made about how to preserve and enhance opportunities for nature experience. Here, we first provide points of consensus across the natural, social, and health sciences on the impacts of nature experience on cognitive functioning, emotional well-being, and other dimensions of mental health. We then show how ecosystem service assessments can be expanded to include mental health, and provide a heuristic, conceptual model for doing so.

  • 8.
    Brynildsrud, Ola B.
    et al.
    Norwegian Inst Publ Hlth, Div Infect Dis & Environm Hlth, Lovisenberggata 8, N-0456 Oslo, Norway.
    Pepperell, Caitlin S.
    Univ Wisconsin, Sch Med & Publ Hlth, Dept Med, Div Infect Dis, Madison, WI 53726 USA;Univ Wisconsin, Sch Med & Publ Hlth, Dept Med Microbiol & Immunol, Madison, WI 53726 USA.
    Suffys, Philip
    Oswaldo Cruz Inst, Lab Mol Biol Appl Mycobacteria, Ave Brasil 4365,CP 926, BR-21040360 Manguinho, RJ, Brazil.
    Grandjean, Louis
    Imperial Coll London, Dept Paediat Infect Dis, London W2 1NY, England.
    Monteserin, Johana
    ANLIS Carlos Malbran, Inst Nacl Enfermedades Infecciosas, Buenos Aires, DF, Argentina;Consejo Nacl Invest Cient & Tecn, Buenos Aires, DF, Argentina.
    Debech, Nadia
    Norwegian Inst Publ Hlth, Div Infect Dis & Environm Hlth, Lovisenberggata 8, N-0456 Oslo, Norway.
    Bohlin, Jon
    Norwegian Inst Publ Hlth, Div Infect Dis & Environm Hlth, Lovisenberggata 8, N-0456 Oslo, Norway.
    Alfsnes, Kristian
    Norwegian Inst Publ Hlth, Div Infect Dis & Environm Hlth, Lovisenberggata 8, N-0456 Oslo, Norway.
    Pettersson, John
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinsk biokemi och mikrobiologi. Norwegian Inst Publ Hlth, Div Infect Dis & Environm Hlth, Lovisenberggata 8, N-0456 Oslo, Norway; Univ Sydney, Charles Perkins Ctr Sch Life & Environm Sci, Marie Bashir Inst Infect Dis & Biosecur, Sydney, NSW 2006, Australia;Univ Sydney, Sydney Med Sch, Sydney, NSW 2006, Australia;Publ Hlth Agcy Sweden, Nobels Vg 18, SE-17182 Solna, Sweden.
    Kirkeleite, Ingerid
    Norwegian Inst Publ Hlth, Div Infect Dis & Environm Hlth, Lovisenberggata 8, N-0456 Oslo, Norway.
    Fandinho, Fatima
    Ctr Referincia Prof Helio Fraga Jacarepagu, Lab Bacteriol Tuberculose, Estr Curic 2000, Rio De Janeiro, RJ, Brazil.
    da Silva, Marcia Aparecida
    Ctr Referincia Prof Helio Fraga Jacarepagu, Lab Bacteriol Tuberculose, Estr Curic 2000, Rio De Janeiro, RJ, Brazil.
    Perdigao, Joao
    Univ Lisbon, Fac Farm, Inst Invest Med, Lisbon, Portugal.
    Portugal, Isabel
    Univ Lisbon, Fac Farm, Inst Invest Med, Lisbon, Portugal.
    Viveiros, Miguel
    Univ Nova Lisboa, Inst Higiene & Med Trop, Unidade Microbiol Med Global Hlth & Trop Med, Lisbon, Portugal.
    Clark, Taane
    London Sch Hyg & Trop Med, Fac Infect & Trop Dis, London WC1E 7HT, England;London Sch Hyg & Trop Med, Fac Epidemiol & Populat Hlth, London WC1E 7HT, England.
    Caws, Maxine
    Univ Liverpool Liverpool Sch Trop Med, Dept Clin Sci, Liverpool, Merseyside, England;Birat Nepal Med Trust, Kathmandu, Nepal.
    Dunstan, Sarah
    Univ Melbourne, Peter Doherty Inst Infect & Immun, Melbourne, Vic, Australia.
    Thai, Phan Vuong Khac
    Lopez, Beatriz
    ANLIS Carlos Malbran, Inst Nacl Enfermedades Infecciosas, Buenos Aires, DF, Argentina.
    Ritacco, Viviana
    ANLIS Carlos Malbran, Inst Nacl Enfermedades Infecciosas, Buenos Aires, DF, Argentina;Consejo Nacl Invest Cient & Tecn, Buenos Aires, DF, Argentina.
    Kitchen, Andrew
    Univ Iowa, Dept Anthropol, Iowa City, IA 52242 USA.
    Brown, Tyler S.
    Massachusetts Gen Hosp, Div Infect Dis, Boston, MA 02114 USA.
    van Soolingen, Dick
    Natl Inst Publ Hlth & Environm, Ctr Infect Dis Res Diagnost & Perinatal Screening, POB 1, NL-3720 BA Bilthoven, Netherlands.
    O'Neill, Mary B.
    Univ Wisconsin, Sch Med & Publ Hlth, Dept Med Microbiol & Immunol, Madison, WI 53726 USA;Univ Wisconsin, Lab Genet, Madison, WI 53706 USA;Inst Pasteur, Unit Human Evolutionary Genet, F-75015 Paris, France.
    Holt, Kathryn E.
    London Sch Hyg & Trop Med, Fac Infect & Trop Dis, London WC1E 7HT, England;Univ Melbourne, Dept Biochem & Mol Biol, Melbourne, Vic, Australia;Univ Melbourne, Inst Bio21, Melbourne, Vic, Australia.
    Feil, Edward J.
    Univ Bath, Milner Ctr Evolut, Dept Biol & Biochem, Bath BA2 7AY, Avon, England.
    Mathema, Barun
    Columbia Univ, Mailman Sch Publ Hlth, 722 West 168th St, New York, NY 10032 USA.
    Balloux, Francois
    UCL, UCL Genet Inst, London WC1E 6BT, England.
    Eldholm, Vegard
    Norwegian Inst Publ Hlth, Div Infect Dis & Environm Hlth, Lovisenberggata 8, N-0456 Oslo, Norway.
    Global expansion of Mycobacterium tuberculosis lineage 4 shaped by colonial migration and local adaptation2018Ingår i: Science Advances, E-ISSN 2375-2548, Vol. 4, nr 10, artikel-id eaat5869Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    On the basis of population genomic and phylogeographic analyses of 1669 Mycobacterium tuberculosis lineage 4 (L4) genomes, we find that dispersal of L4 has been completely dominated by historical migrations out of Europe. We demonstrate an intimate temporal relationship between European colonial expansion into Africa and the Americas and the spread of L4 tuberculosis (TB). Markedly, in the age of antibiotics, mutations conferring antimicrobial resistance overwhelmingly emerged locally (at the level of nations), with minimal cross-border transmission of resistance. The latter finding was found to reflect the relatively recent emergence of these mutations, as a similar degree of local restriction was observed for susceptible variants emerging on comparable time scales. The restricted international transmission of drug-resistant TB suggests that containment efforts at the level of individual countries could be successful.

  • 9.
    Budd, Graham E.
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Geovetenskapliga sektionen, Institutionen för geovetenskaper, Paleobiologi.
    Mann, Richard P
    Department of Statistics, School of Mathematics, University of Leeds, Leeds, UK; The Alan Turing Institute, London, UK.
    The dynamics of stem and crown groups2020Ingår i: Science Advances, E-ISSN 2375-2548, Vol. 6, nr 8, artikel-id eaaz1626Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The fossil record of the origins of major groups such as animals and birds has generated considerable controversy, especially when it conflicts with timings based on molecular clock estimates. Here, we model the diversity of "stem" (basal) and "crown" (modern) members of groups using a "birth-death model," the results of which qualitatively match many large-scale patterns seen in the fossil record. Typically, the stem group diversifies rapidly until the crown group emerges, at which point its diversity collapses, followed shortly by its extinction. Mass extinctions can disturb this pattern and create long stem groups such as the dinosaurs. Crown groups are unlikely to emerge either cryptically or just before mass extinctions, in contradiction to popular hypotheses such as the "phylogenetic fuse". The patterns revealed provide an essential context for framing ecological and evolutionary explanations for how major groups originate, and strengthen our confidence in the reliability of the fossil record.

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  • 10. Busker, S.
    et al.
    Qian, Wang
    Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
    Haraldsson, M.
    Espinosa, B.
    Johansson, L.
    Attarha, S.
    Kolosenko, I
    Liu, J.
    Dagnell, M.
    Grander, D.
    Arner, E. S. J.
    Tamm, K. Pokrovskaja
    Page, B. D. G.
    Irreversible TrxR1 inhibitors block STAT3 activity and induce cancer cell death2020Ingår i: Science Advances, E-ISSN 2375-2548, Vol. 6, nr 12, artikel-id eaax7945Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Because of its key role in cancer development and progression, STAT3 has become an attractive target for developing new cancer therapeutics. While several STAT3 inhibitors have progressed to advanced stages of development, their underlying biology and mechanisms of action are often more complex than would be expected from specific binding to STAT3. Here, we have identified and optimized a series of compounds that block STAT3-dependent luciferase expression with nanomolar potency. Unexpectedly, our lead compounds did not bind to cellular STAT3 but to another prominent anticancer drug target, TrxR1. We further identified that TrxR1 inhibition induced Prx2 and STAT3 oxidation, which subsequently blocked STAT3-dependent transcription. Moreover, previously identified inhibitors of STAT3 were also found to inhibit TrxR1, and likewise, established TrxR1 inhibitors block STAT3-dependent transcriptional activity. These results provide new insights into the complexities of STAT3 redox regulation while highlighting a novel mechanism to block aberrant STAT3 signaling in cancer cells.

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  • 11. Cedernaes, Jonathan
    et al.
    Schonke, Milena
    Orzechowski Westholm, Jakub
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för biokemi och biofysik. Stockholms universitet, Science for Life Laboratory (SciLifeLab).
    Mi, Jia
    Chibalin, Alexander
    Voisin, Sarah
    Osler, Megan
    Vogel, Heike
    Hornaeus, Katarina
    Dickson, Suzanne L.
    Lind, Sara Bergstrom
    Bergquist, Jonas
    Schioth, Helgi B.
    Zierath, Juleen R.
    Benedict, Christian
    Acute sleep loss results in tissue-specific alterations in genome-wide DNA methylation state and metabolic fuel utilization in humans2018Ingår i: Science Advances, ISSN 0036-8156, E-ISSN 2375-2548, Vol. 4, nr 8, artikel-id eaar8590Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Curtailed sleep promotes weight gain and loss of lean mass in humans, although the underlying molecular mechanisms are poorly understood. We investigated the genomic and physiological impact of acute sleep loss in peripheral tissues by obtaining adipose tissue and skeletal muscle after one night of sleep loss and after one full night of sleep. We find that acute sleep loss alters genome-wide DNA methylation in adipose tissue, and unbiased transcriptome-, protein-, and metabolite-level analyses also reveal highly tissue-specific changes that are partially reflected by altered metabolite levels in blood. We observe transcriptomic signatures of inflammation in both tissues following acute sleep loss, but changes involving the circadian clock are evident only in skeletal muscle, and we uncover molecular signatures suggestive of muscle breakdown that contrast with an anabolic adipose tissue signature. Our findings provide insight into how disruption of sleep and circadian rhythms may promote weight gain and sarcopenia.

  • 12.
    Cedernaes, Jonathan
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Funktionell farmakologi.
    Schonke, Milena
    Karolinska Inst, Dept Mol Med & Surg, Solna, Sweden.
    Westholm, Jakub Orzechowski
    Stockholm Univ, Dept Biochem & Biophys, Sci Life Lab, Stockholm, Sweden.
    Mi, Jia
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - BMC, Analytisk kemi. Binzhou Med Univ, Med & Pharmarcy Res Ctr, Yantai, Peoples R China.
    Chibalin, Alexander
    Karolinska Inst, Dept Mol Med & Surg, Solna, Sweden.
    Voisin, Sarah
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Funktionell farmakologi.
    Osler, Megan
    Karolinska Inst, Dept Mol Med & Surg, Solna, Sweden.
    Vogel, Heike
    German Inst Human Nutr Potsdam Rehbrucke, Dept Expt Diabetol, Potsdam, Germany.
    Hornaeus, Katarina
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - BMC.
    Dickson, Suzanne L.
    Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Physiol Endocrinol, Gothenburg, Sweden.
    Lind, Sara
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - BMC, Analytisk kemi.
    Bergquist, Jonas
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - BMC, Analytisk kemi. Univ Utah, Dept Pathol, Salt Lake City, UT 84132 USA;Binzhou Med Univ, Precis Med, Yantai, Peoples R China.
    Schiöth, Helgi B.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Funktionell farmakologi.
    Zierath, Juleen R.
    Karolinska Inst, Dept Mol Med & Surg, Solna, Sweden.
    Benedict, Christian
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Funktionell farmakologi.
    Acute sleep loss results in tissue-specific alterations in genome-wide DNA methylation state and metabolic fuel utilization in humans2018Ingår i: Science Advances, E-ISSN 2375-2548, Vol. 4, nr 8, artikel-id eaar8590Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Curtailed sleep promotes weight gain and loss of lean mass in humans, although the underlying molecular mechanisms are poorly understood. We investigated the genomic and physiological impact of acute sleep loss in peripheral tissues by obtaining adipose tissue and skeletal muscle after one night of sleep loss and after one full night of sleep. We find that acute sleep loss alters genome-wide DNA methylation in adipose tissue, and unbiased transcriptome-, protein-, and metabolite-level analyses also reveal highly tissue-specific changes that are partially reflected by altered metabolite levels in blood. We observe transcriptomic signatures of inflammation in both tissues following acute sleep loss, but changes involving the circadian clock are evident only in skeletal muscle, and we uncover molecular signatures suggestive of muscle breakdown that contrast with an anabolic adipose tissue signature. Our findings provide insight into how disruption of sleep and circadian rhythms may promote weight gain and sarcopenia.

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  • 13.
    Chapman, Colin Daniel
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Funktionell farmakologi.
    Benedict, Christian
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Funktionell farmakologi.
    Schiöth, Helgi B.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Funktionell farmakologi.
    Experimenter gender and replicability in science2018Ingår i: Science Advances, E-ISSN 2375-2548, Vol. 4, nr 1, artikel-id e1701427Artikel, forskningsöversikt (Refereegranskat)
    Abstract [en]

    There is a replication crisis spreading through the annals of scientific inquiry. Although some work has been carried out to uncover the roots of this issue, much remains unanswered. With this in mind, this paper investigates how the gender of the experimenter may affect experimental findings. Clinical trials are regularly carried out without any report of the experimenter's gender and with dubious knowledge of its influence. Consequently, significant biases caused by the experimenter's gender may lead researchers to conclude that therapeutics or other interventions are either overtreating or undertreating a variety of conditions. Bearing this in mind, this policy paper emphasizes the importance of reporting and controlling for experimenter gender in future research. As backdrop, it explores what we know about the role of experimenter gender in influencing laboratory results, suggests possible mechanisms, and suggests future areas of inquiry.

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  • 14. Clark, C. J.
    et al.
    Pletsch, H. J.
    Wu, J.
    Guillemot, L.
    Kerr, M.
    Johnson, T. J.
    Camilo, F.
    Salvetti, D.
    Allen, B.
    Anderson, D.
    Aulbert, C.
    Beer, C.
    Bock, O.
    Cuéllar, A.
    Eggenstein, H. -B
    Fehrmann, H.
    Kramer, M.
    Kwang, S. A.
    MacHenschalk, B.
    Nieder, L.
    Ackermann, M.
    Ajello, M.
    Baldini, L.
    Ballet, J.
    Barbiellini, G.
    Bastieri, D.
    Bellazzini, R.
    Bissaldi, E.
    Blandford, R. D.
    Bloom, E. D.
    Bonino, R.
    Bottacini, E.
    Brandt, T. J.
    Bregeon, J.
    Bruel, P.
    Buehler, R.
    Burnett, T. H.
    Buson, S.
    Cameron, R. A.
    Caputo, R.
    Caraveo, P. A.
    Cavazzuti, E.
    Cecchi, C.
    Charles, E.
    Chekhtman, A.
    Ciprini, S.
    Cominsky, L. R.
    Costantin, D.
    Cutini, S.
    D'Ammando, F.
    De Luca, A.
    Desiante, R.
    Di Venere, L.
    Di Mauro, M.
    Di Lalla, N.
    Digel, S. W.
    Favuzzi, C.
    Ferrara, E. C.
    Franckowiak, A.
    Fukazawa, Y.
    Funk, S.
    Fusco, P.
    Gargano, F.
    Gasparrini, D.
    Giglietto, N.
    Giordano, F.
    Giroletti, M.
    Gomez-Vargas, G. A.
    Green, D.
    Grenier, I. A.
    Guiriec, S.
    Harding, A. K.
    Hewitt, J. W.
    Horan, D.
    Jóhannesson, G.
    Kensei, S.
    Kuss, M.
    La Mura, G.
    Larsson, Stefan
    KTH, Skolan för teknikvetenskap (SCI), Fysik. The Oskar Klein Centre for Cosmoparticle Physics, AlbaNova, SE-106 91 Stockholm, Sweden..
    Latronico, L.
    Li, J.
    Longo, F.
    Loparco, F.
    Lovellette, M. N.
    Lubrano, P.
    Magill, J. D.
    Maldera, S.
    Manfreda, A.
    Mazziotta, M. N.
    McEnery, J. E.
    Michelson, P. F.
    Mirabal, N.
    Mitthumsiri, W.
    Mizuno, T.
    Monzani, M. E.
    Morselli, A.
    Moskalenko, I. V.
    Nuss, E.
    Ohsugi, T.
    Omodei, N.
    Orienti, M.
    Orlando, E.
    Palatiello, M.
    Paliya, V. S.
    De Palma, F.
    Paneque, D.
    Perkins, J. S.
    Persic, M.
    Pesce-Rollins, M.
    Porter, T. A.
    Principe, G.
    Rainò, S.
    Rando, R.
    Ray, P. S.
    Razzano, M.
    Reimer, A.
    Reimer, O.
    Romani, R. W.
    Parkinson, P. M. S.
    Sgrò, C.
    Siskind, E. J.
    Smith, D. A.
    Spada, F.
    Spandre, G.
    Spinelli, P.
    Thayer, J. B.
    Thompson, D. J.
    Torres, D. F.
    Troja, E.
    Vianello, G.
    Wood, K.
    Wood, M.
    Einstein@Home discovers a radio-quiet gamma-ray millisecond pulsar2018Ingår i: Science Advances, ISSN 0036-8156, E-ISSN 2375-2548, Vol. 4, nr 2, artikel-id eaao7228Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Millisecond pulsars (MSPs) are old neutron stars that spin hundreds of times per second and appear to pulsate as their emission beams cross our line of sight. To date,radio pulsations have been detected from all rotation-powered MSPs. In an attempt to discover radio-quiet gamma-ray MSPs,we used the aggregated power from the computers of tens of thousands of volunteers participating in the Einstein@Home distributed computing project to search for pulsations from unidentified gamma-ray sources in Fermi Large Area Telescope data. This survey discovered two isolated MSPs,one of which is the only known rotation-powered MSP to remain undetected in radio observations. These gamma-ray MSPs were discovered in completely blind searches without prior constraints from other observations,raising hopes for detecting MSPs from a predicted Galactic bulge population. 

  • 15. Cook, Edward R.
    et al.
    Seager, Richard
    Kushnir, Yochanan
    Briffa, Keith R.
    Buntgen, Ulf
    Frank, David
    Krusic, Paul J.
    Tegel, Willy
    van der Schrier, Gerard
    Andreu-Hayles, Laia
    Baillie, Mike
    Baittinger, Claudia
    Bleicher, Niels
    Bonde, Niels
    Brown, David
    Carrer, Marco
    Cooper, Richard
    Cufar, Katarina
    Dittmar, Christoph
    Esper, Jan
    Griggs, Carol
    Gunnarson, Björn
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för naturgeografi.
    Guenther, Bjorn
    Gutierrez, Emilia
    Haneca, Kristof
    Helama, Samuli
    Herzig, Franz
    Heussner, Karl-Uwe
    Hofmann, Jutta
    Janda, Pavel
    Kontic, Raymond
    Kose, Nesibe
    Kyncl, Tomas
    Levanic, Tom
    Linderholm, Hans
    Manning, Sturt
    Melvin, Thomas M.
    Miles, Daniel
    Neuwirth, Burkhard
    Nicolussi, Kurt
    Nola, Paola
    Panayotov, Momchil
    Popa, Ionel
    Rothe, Andreas
    Seftigen, Kristina
    Seim, Andrea
    Svarva, Helene
    Svoboda, Miroslav
    Thun, Terje
    Timonen, Mauri
    Touchan, Ramzi
    Trotsiuk, Volodymyr
    Trouet, Valerie
    Walder, Felix
    Wazny, Tomasz
    Wilson, Rob
    Zang, Christian
    Old World megadroughts and pluvials during the Common Era2015Ingår i: Science Advances, ISSN 0036-8156, E-ISSN 2375-2548, Vol. 1, nr 10, artikel-id e1500561Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Climate model projections suggest widespread drying in the Mediterranean Basin and wetting in Fennoscandia in the coming decades largely as a consequence of greenhouse gas forcing of climate. To place these and other Old World climate projections into historical perspective based on more complete estimates of natural hydroclimatic variability, we have developed the Old World Drought Atlas (OWDA), a set of year-to-year maps of tree-ring reconstructed summer wetness and dryness over Europe and the Mediterranean Basin during the Common Era. The OWDA matches historical accounts of severe drought and wetness with a spatial completeness not previously available. In addition, megadroughts reconstructed over north-central Europe in the 11th and mid-15th centuries reinforce other evidence from North America and Asia that droughts were more severe, extensive, and prolonged over Northern Hemisphere land areas before the 20th century, with an inadequate understanding of their causes. The OWDA provides new data to determine the causes of Old World drought and wetness and attribute past climate variability to forced and/or internal variability.

  • 16.
    Corral-López, Alberto
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Zoologiska institutionen.
    Bloch, Natasha I.
    Kotrschal, Alexander
    Stockholms universitet, Naturvetenskapliga fakulteten, Zoologiska institutionen.
    van der Bijl, Wouter
    Stockholms universitet, Naturvetenskapliga fakulteten, Zoologiska institutionen.
    Buechel, Severine D.
    Stockholms universitet, Naturvetenskapliga fakulteten, Zoologiska institutionen.
    Mank, Judith E.
    Kolm, Niclas
    Stockholms universitet, Naturvetenskapliga fakulteten, Zoologiska institutionen.
    Female brain size affects the assessment of male attractiveness during mate choice2017Ingår i: Science Advances, ISSN 0036-8156, E-ISSN 2375-2548, Vol. 3, nr 3, artikel-id e1601990Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Mate choice decisions are central in sexual selection theory aimed to understand how sexual traits evolve and their role in evolutionary diversification. We test the hypothesis that brain size and cognitive ability are important for accurate assessment of partner quality and that variation in brain size and cognitive ability underlies variation in mate choice. We compared sexual preference in guppy female lines selected for divergence in relative brain size, which we have previously shown to have substantial differences in cognitive ability. In a dichotomous choice test, large-brained and wild-type females showed strong preference for males with color traits that predict attractiveness in this species. In contrast, small-brained females showed no preference for males with these traits. In-depth analysis of optomotor response to color cues and gene expression of key opsins in the eye revealed that the observed differences were not due to differences in visual perception of color, indicating that differences in the ability to process indicators of attractiveness are responsible. We thus provide the first experimental support that individual variation in brain size affects mate choice decisions and conclude that differences in cognitive ability may be an important underlying mechanism behind variation in female mate choice.

  • 17. Cravcenco, A.
    et al.
    Hertzog, M.
    Ye, C.
    Iqbal, Muhammad Naeem
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK).
    Mueller, U.
    Eriksson, Lars
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för material- och miljökemi (MMK).
    Borjesson, K.
    Multiplicity conversion based on intramolecular triplet-to-singlet energy transfer2019Ingår i: Science Advances, E-ISSN 2375-2548, Vol. 5, nr 9, artikel-id eaaw5978Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The ability to convert between molecular spin states is of utmost importance in materials chemistry. Forster-type energy transfer is based on dipole-dipole interactions and can therefore theoretically be used to convert between molecular spin states. Here, a molecular dyad that is capable of transferring energy from an excited triplet state to an excited singlet state is presented. The rate of conversion between these states was shown to be 36 times faster than the rate of emission from the isolated triplet state. This dyad provides the first solid proof that Forster-type triplet-to-singlet energy transfer is possible, revealing a method to increase the rate of light extraction from excited triplet states.

  • 18.
    Dahlqvist, Martin
    et al.
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Tunnfilmsfysik. Linköpings universitet, Tekniska fakulteten.
    Lu, Jun
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Tunnfilmsfysik. Linköpings universitet, Tekniska fakulteten.
    Meshkian, Rahele
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Tunnfilmsfysik. Linköpings universitet, Tekniska fakulteten.
    Tao, Quanzheng
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Tunnfilmsfysik. Linköpings universitet, Tekniska fakulteten.
    Hultman, Lars
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Tunnfilmsfysik. Linköpings universitet, Tekniska fakulteten.
    Rosén, Johanna
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Tunnfilmsfysik. Linköpings universitet, Tekniska fakulteten.
    Prediction and synthesis of a family of atomic laminate phases with Kagome-like and in-plane chemical ordering2017Ingår i: Science Advances, ISSN 0036-8156, E-ISSN 2375-2548, Vol. 3, nr 7, artikel-id e1700642Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The enigma of MAX phases and their hybrids prevails. We probe transition metal (M) alloying in MAX phases for metal size, electronegativity, and electron configuration, and discover ordering in these MAX hybrids, namely, (V2/3Zr1/3)(2)AlC and (Mo2/3Y1/3)(2)AlC. Predictive theory and verifying materials synthesis, including a judicious choice of alloying M from groups III to VI and periods 4 and 5, indicate a potentially large family of thermodynamically stable phases, with Kagome-like and in-plane chemical ordering, and with incorporation of elements previously not known for MAX phases, including the common Y. We propose the structure to be monoclinic C2/c. As an extension of the work, we suggest a matching set of novel MXenes, from selective etching of the A-element. The demonstrated structural design on simultaneous two-dimensional (2D) and 3D atomic levels expands the property tuning potential of functional materials.

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  • 19.
    Daly, L.
    et al.
    Univ Glasgow, Sch Geog & Earth Sci, Glasgow G12 8QQ, Lanark, Scotland;Curtin Univ, Sch Earth & Planetary Sci, Space Sci & Technol Ctr, GPO Box U1987, Perth, WA 6845, Australia;Univ Sydney, Australian Ctr Microscopy & Microanal, Sydney, NSW 2006, Australia.
    Lee, M. R.
    Univ Glasgow, Sch Geog & Earth Sci, Glasgow G12 8QQ, Lanark, Scotland.
    Piazolo, S.
    Univ Leeds, Sch Earth & Environm, Leeds LS2 9JT, W Yorkshire, England.
    Griffin, S.
    Univ Glasgow, Sch Geog & Earth Sci, Glasgow G12 8QQ, Lanark, Scotland.
    Bazargan, Mohsen
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Geovetenskapliga sektionen, Institutionen för geovetenskaper, Geofysik.
    Campanale, F.
    Univ Glasgow, Sch Geog & Earth Sci, Glasgow G12 8QQ, Lanark, Scotland;Univ Pisa, Dipartimento Sci Terra, Via Santa Maria 53, I-56126 Pisa, Italy.
    Chung, P.
    Univ Glasgow, Sch Geog & Earth Sci, Glasgow G12 8QQ, Lanark, Scotland.
    Cohen, B. E.
    Univ Glasgow, Sch Geog & Earth Sci, Glasgow G12 8QQ, Lanark, Scotland.
    Pickersgill, A. E.
    Univ Glasgow, Sch Geog & Earth Sci, Glasgow G12 8QQ, Lanark, Scotland.
    Hallis, L. J.
    Univ Glasgow, Sch Geog & Earth Sci, Glasgow G12 8QQ, Lanark, Scotland.
    Trimby, P. W.
    Oxford Instruments Nanoanal, High Wycombe HP12 3SE, Bucks, England.
    Baumgartner, R.
    Univ New South Wales, Australian Ctr Astrobiol, Sydney, NSW 2052, Australia.
    Forman, L. V.
    Curtin Univ, Sch Earth & Planetary Sci, Space Sci & Technol Ctr, GPO Box U1987, Perth, WA 6845, Australia.
    Benedix, G. K.
    Curtin Univ, Sch Earth & Planetary Sci, Space Sci & Technol Ctr, GPO Box U1987, Perth, WA 6845, Australia;Western Australian Museum, Dept Earth & Planetary Sci, Locked Bag 49, Welshpool, WA 6986, Australia;Planetary Sci Inst, 1700 East Ft Lowell,Suite 106, Tucson, AZ 85719 USA.
    Boom boom pow: Shock-facilitated aqueous alteration and evidence for two shock events in the Martian nakhlite meteorites2019Ingår i: Science Advances, E-ISSN 2375-2548, Vol. 5, nr 9, artikel-id eaaw5549Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Nakhlite meteorites are similar to 1.4 to 1.3 Ga old igneous rocks, aqueously altered on Mars similar to 630 Ma ago. We test the theory that water-rock interaction was impact driven. Electron backscatter diffraction demonstrates that the meteorites Miller Range 03346 and Lafayette were heterogeneously deformed, leading to localized regions of brecciation, plastic deformation, and mechanical twinning of augite. Numerical modeling shows that the pattern of deformation is consistent with shock-generated compressive and tensile stresses. Mesostasis within shocked areas was aqueously altered to phyllosilicates, carbonates, and oxides, suggesting a genetic link between the two processes. We propose that an impact similar to 630 Ma ago simultaneously deformed the nakhlite parent rocks and generated liquid water by melting of permafrost. Ensuing water-rock interaction focused on shocked mesostasis with a high density of reactive sites. The nakhlite source location must have two spatially correlated craters, one similar to 630 Ma old and another, ejecting the meteorites, similar to 11 Ma ago.

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    FULLTEXT01
  • 20.
    Dasari, Sanjeev
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljövetenskap och analytisk kemi.
    Andersson, August
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljövetenskap och analytisk kemi.
    Bikkina, Srinivas
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljövetenskap och analytisk kemi.
    Holmstrand, Henry
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljövetenskap och analytisk kemi.
    Budhavant, Krishnakant
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljövetenskap och analytisk kemi. Maldives Climate Observatory at Hanimaadhoo (MCOH), Republic of the Maldives; Indian Institute of Sciences (IISC), India.
    Satheesh, Sreedharan
    Asmi, Eija
    Kesti, Jutta
    Backman, John
    Salam, Abdus
    Bisht, Deewan Singh
    Tiwari, Suresh
    Hameed, Zahid
    Gustafsson, Örjan
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för miljövetenskap och analytisk kemi.
    Photochemical degradation affects the light absorption of water-soluble brown carbon in the South Asian outflow2019Ingår i: Science Advances, E-ISSN 2375-2548, Vol. 5, nr 1, artikel-id eaau8066Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Light-absorbing organic aerosols, known as brown carbon (BrC), counteract the overall cooling effect of aerosols on Earth's climate. The spatial and temporal dynamics of their light-absorbing properties are poorly constrained and unaccounted for in climate models, because of limited ambient observations. We combine carbon isotope forensics (delta C-13) with measurements of light absorption in a conceptual aging model to constrain the loss of light absorptivity (i.e., bleaching) of water-soluble BrC (WS-BrC) aerosols in one of the world's largest BrC emission regions-South Asia. On this regional scale, we find that atmospheric photochemical oxidation reduces the light absorption of WS-BrC by similar to 84% during transport over 6000 km in the Indo-Gangetic Plain, with an ambient first-order bleaching rate of 0.20 +/- 0.05 day(-1) during over-ocean transit across Bay of Bengal to an Indian Ocean receptor site. This study facilitates dynamic parameterization of WS-BrC absorption properties, thereby constraining BrC climate impact over South Asia.

  • 21.
    Demchyshyn, Stepan
    et al.
    Johannes Kepler University of Linz, Austria; Johannes Kepler University of Linz, Austria; LIT, Austria.
    Melanie Roemer, Janina
    Ludwig Maximilians University of Munchen, Germany; Ludwig Maximilians University of Munchen, Germany.
    Groiss, Heiko
    Johannes Kepler University of Linz, Austria; Johannes Kepler University of Linz, Austria.
    Heilbrunner, Herwig
    Johannes Kepler University of Linz, Austria.
    Ulbricht, Christoph
    Johannes Kepler University of Linz, Austria; Johannes Kepler University of Linz, Austria.
    Apaydin, Dogukan
    Johannes Kepler University of Linz, Austria.
    Boehm, Anton
    Ludwig Maximilians University of Munchen, Germany; Ludwig Maximilians University of Munchen, Germany.
    Ruett, Uta
    DESY, Germany.
    Bertram, Florian
    DESY, Germany.
    Hesser, Guenter
    Johannes Kepler University of Linz, Austria.
    Clark Scharber, Markus
    Johannes Kepler University of Linz, Austria.
    Serdar Sariciftci, Niyazi
    Johannes Kepler University of Linz, Austria.
    Nickel, Bert
    Ludwig Maximilians University of Munchen, Germany; Ludwig Maximilians University of Munchen, Germany; Nanosyst Initiat Munich, Germany.
    Bauer, Siegfried
    Johannes Kepler University of Linz, Austria.
    Glowacki, Eric
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Fysik och elektroteknik. Linköpings universitet, Tekniska fakulteten.
    Kaltenbrunner, Martin
    Johannes Kepler University of Linz, Austria; LIT, Austria.
    Confining metal-halide perovskites in nanoporous thin films2017Ingår i: Science Advances, ISSN 0036-8156, E-ISSN 2375-2548, Vol. 3, nr 8, artikel-id e1700738Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Controlling the size and shape of semiconducting nanocrystals advances nanoelectronics and photonics. Quantumconfined, inexpensive, solution-derived metal halide perovskites offer narrowband, color-pure emitters as integral parts of next-generation displays and optoelectronic devices. We use nanoporous silicon and alumina thin films as templates for the growth of perovskite nanocrystallites directly within device-relevant architectures without the use of colloidal stabilization. We find significantly blue-shifted photoluminescence emission by reducing the pore size; normally infrared-emitting materials become visibly red, and green-emitting materials become cyan and blue. Confining perovskite nanocrystals within porous oxide thin films drastically increases photoluminescence stability because the templates auspiciously serve as encapsulation. We quantify the template-induced size of the perovskite crystals in nanoporous silicon with microfocus high-energy x-ray depth profiling in transmission geometry, verifying the growth of perovskite nanocrystals throughout the entire thickness of the nanoporous films. Low-voltage electroluminescent diodes with narrow, blue-shifted emission fabricated from nanocrystalline perovskites grown in embedded nanoporous alumina thin films substantiate our general concept for next-generation photonic devices.

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    fulltext
  • 22.
    Dimmock, Andrew P.
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutet för rymdfysik, Uppsalaavdelningen.
    Russell, Christopher T.
    Univ Calif Los Angeles, Dept Earth Planetary & Space Sci, Los Angeles, CA 90095 USA.
    Sagdeev, Roald Z.
    Univ Maryland, Dept Phys, College Pk, MD 20742 USA.
    Krasnoselskikh, Vladimir
    Univ Orleans, CNRS, LPC2E, Orleans, France;Univ Calif Berkeley, Space Sci Lab, 7 Gauss Way, Berkeley, CA 94720 USA.
    Walker, Simon N.
    Univ Sheffield, Dept Automat Control & Syst Engn, Sheffield, S Yorkshire, England.
    Carr, Christopher
    Imperial Coll London, London SW7 2AZ, England.
    Dandouras, Iannis
    Univ Toulouse, IRAP, CNRS, UPS,CNES, Toulouse, France.
    Escoubet, C. Philippe
    European Space Agcy, European Space Res & Technol Ctr ESA ESTEC, Noordwijk, Netherlands.
    Ganushkina, Natalia
    Finnish Meteorol Inst, Helsinki, Finland;Univ Michigan, Ann Arbor, MI 48109 USA.
    Gedalin, Michael
    Ben Gurion Univ Negev, Dept Phys, Beer Sheva, Israel.
    Khotyaintsev, Yuri V.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutet för rymdfysik, Uppsalaavdelningen.
    Aryan, Homayon
    Univ Sheffield, Dept Automat Control & Syst Engn, Sheffield, S Yorkshire, England;NASA Goddard Space Flight Ctr, Greenbelt, MD 20771 USA.
    Pulkkinen, Tuija, I
    Univ Michigan, Ann Arbor, MI 48109 USA;Aalto Univ, Sch Elect Engn, Dept Elect & Nanoengn, Espoo, Finland.
    Balikhin, Michael A.
    Univ Sheffield, Dept Automat Control & Syst Engn, Sheffield, S Yorkshire, England.
    Direct evidence of nonstationary collisionless shocks in space plasmas2019Ingår i: Science Advances, E-ISSN 2375-2548, Vol. 5, nr 2, artikel-id eaau9926Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Collisionless shocks are ubiquitous throughout the universe: around stars, supernova remnants, active galactic nuclei, binary systems, comets, and planets. Key information is carried by electromagnetic emissions from particles accelerated by high Mach number collisionless shocks. These shocks are intrinsically nonstationary, and the characteristic physical scales responsible for particle acceleration remain unknown. Quantifying these scales is crucial, as it affects the fundamental process of redistributing upstream plasma kinetic energy into other degrees of freedom-particularly electron thermalization. Direct in situ measurements of nonstationary shock dynamics have not been reported. Thus, the model that best describes this process has remained unknown. Here, we present direct evidence demonstrating that the transition to nonstationarity is associated with electron-scale field structures inside the shock ramp.

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    FULLTEXT01
  • 23.
    Douvlataniotis, Karolos
    et al.
    Linköpings universitet, Institutionen för biomedicinska och kliniska vetenskaper, Avdelningen för barns och kvinnors hälsa. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Barn- och kvinnocentrum, H.K.H. Kronprinsessan Victorias barn- och ungdomssjukhus Linköping/Motala.
    Bensberg, Maike
    Linköpings universitet, Institutionen för biomedicinska och kliniska vetenskaper, Avdelningen för barns och kvinnors hälsa. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Barn- och kvinnocentrum, H.K.H. Kronprinsessan Victorias barn- och ungdomssjukhus Linköping/Motala.
    Lentini, Antonio
    Linköpings universitet, Institutionen för biomedicinska och kliniska vetenskaper, Avdelningen för barns och kvinnors hälsa. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Barn- och kvinnocentrum, H.K.H. Kronprinsessan Victorias barn- och ungdomssjukhus Linköping/Motala.
    Gylemo, Björn
    Linköpings universitet, Institutionen för biomedicinska och kliniska vetenskaper, Avdelningen för barns och kvinnors hälsa. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Barn- och kvinnocentrum, H.K.H. Kronprinsessan Victorias barn- och ungdomssjukhus Linköping/Motala.
    Nestor, Colm
    Linköpings universitet, Institutionen för biomedicinska och kliniska vetenskaper, Avdelningen för barns och kvinnors hälsa. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Barn- och kvinnocentrum, H.K.H. Kronprinsessan Victorias barn- och ungdomssjukhus Linköping/Motala.
    No evidence for DNA N-6-methyladenine in mammals2020Ingår i: Science Advances, E-ISSN 2375-2548, Vol. 6, nr 12, artikel-id eaay3335Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    N-6-methyladenine (6mdA) is a widespread DNA modification in bacteria. More recently, 6mdA has also been characterized in mammalian DNA. However, measurements of 6mdA abundance and profiles are often very dissimilar between studies, even when performed on DNA from identical mammalian cell types. Using comprehensive bioinformatics analyses of published data and novel experimental approaches, we reveal that efforts to assay 6mdA in mammals have been severely compromised by bacterial contamination, RNA contamination, technological limitations, and antibody nonspecificity. These complications render 6mdA an exceptionally problematic DNA modification to study and have resulted in erroneous detection of 6mdA in several mammalian systems. Together, our results strongly imply that the evidence published to date is not sufficient to support the presence of 6mdA in mammals.

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  • 24. Edgar, Graham J.
    et al.
    Alexander, Timothy J.
    Lefcheck, Jonathan S.
    Bates, Amanda E.
    Kininmonth, Stuart J.
    Stockholms universitet, Naturvetenskapliga fakulteten, Stockholm Resilience Centre. University of the South Pacific, Fiji Islands.
    Thomson, Russell J.
    Duffy, J. Emmett
    Costello, Mark J.
    Stuart-Smith, Rick D.
    Abundance and local-scale processes contribute to multi-phyla gradients in global marine diversity2017Ingår i: Science Advances, ISSN 0036-8156, E-ISSN 2375-2548, Vol. 3, nr 10, artikel-id e1700419Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Among themost enduring ecological challenges is an integrated theory explaining the latitudinal biodiversity gradient, including discrepancies observed at different spatial scales. Analysis of Reef Life Survey data for 4127 marine species at 2406 coral and rocky sites worldwide confirms that the total ecoregion richness peaks in low latitudes, near +15 degrees N and -15 degrees S. However, although richness at survey sites is maximal near the equator for vertebrates, it peaks at high latitudes for large mobile invertebrates. Site richness for different groups is dependent on abundance, which is in turn correlated with temperature for fishes and nutrients for macroinvertebrates. We suggest that temperature-mediated fish predation and herbivory have constrained mobile macroinvertebrate diversity at the site scale across the tropics. Conversely, at the ecoregion scale, richness responds positively to coral reef area, highlighting potentially huge global biodiversity losses with coral decline. Improved conservation outcomes require management frameworks, informed by hierarchical monitoring, that cover differing site- and regional-scale processes across diverse taxa, including attention to invertebrate species, which appear disproportionately threatened by warming seas.

  • 25. Elliott, Mark
    et al.
    Favre-Guilmard, Christine
    Liu, Sai Man
    Maignel, Jacquie
    Masuyer, Geoffrey
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för biokemi och biofysik.
    Beard, Matthew
    Boone, Christopher
    Carre, Denis
    Kalinichev, Mikhail
    Lezmi, Stephane
    Mir, Imran
    Nicoleau, Camille
    Palan, Shilpa
    Perier, Cindy
    Raban, Elsa
    Zhang, Sicai
    Dong, Min
    Stenmark, Pål
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för biokemi och biofysik. Lund University, Sweden.
    Krupp, Johannes
    Engineered botulinum neurotoxin B with improved binding to human receptors has enhanced efficacy in preclinical models2019Ingår i: Science Advances, E-ISSN 2375-2548, Vol. 5, nr 1, artikel-id eaau7196Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Although botulinum neurotoxin serotype A (BoNT/A) products are common treatments for various disorders, there is only one commercial BoNT/B product, whose low potency, likely stemming from low affinity toward its human receptor synaptotagmin 2 (hSyt2), has limited its therapeutic usefulness. We express and characterize two full-length recombinant BoNT/B1 proteins containing designed mutations E1191M/S1199Y (rBoNT/B1(MY)) and E1191Q/S1199W (rBoNT/B1(QW)) that enhance binding to hSyt2. In preclinical models including human-induced pluripotent stem cell neurons and a humanized transgenic mouse, this increased hSyt2 affinity results in high potency, comparable to that of BoNT/A. Last, we solve the cocrystal structure of rBoNT/B1(MY) in complex with peptides of hSyt2 and its homolog hSyt1. We demonstrate that neuronal surface receptor binding limits the clinical efficacy of unmodified BoNT/B and that modified BoNT/B proteins have promising clinical potential.

  • 26.
    Fabiano, Simone
    et al.
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Fysik och elektroteknik. Linköpings universitet, Tekniska fakulteten.
    Abdollahi Sani, Negar
    Linköpings universitet, Institutionen för teknik och naturvetenskap. Linköpings universitet, Tekniska fakulteten. RISE Acreo, Sweden.
    Kawahara, Jun
    RISE Acreo, Sweden; LINTEC Corp, Japan.
    Kergoat, Loig
    Linköpings universitet, Institutionen för teknik och naturvetenskap. Linköpings universitet, Tekniska fakulteten. Aix Marseille University, France.
    Nissa, Josefin
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Fysik och elektroteknik. Linköpings universitet, Tekniska fakulteten.
    Engquist, Isak
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Fysik och elektroteknik. Linköpings universitet, Tekniska fakulteten.
    Crispin, Xavier
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Fysik och elektroteknik. Linköpings universitet, Tekniska fakulteten.
    Berggren, Magnus
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Fysik och elektroteknik. Linköpings universitet, Tekniska fakulteten.
    Ferroelectric polarization induces electronic nonlinearity in ion-doped conducting polymers2017Ingår i: Science Advances, ISSN 0036-8156, E-ISSN 2375-2548, Vol. 3, nr 6, artikel-id e1700345Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Poly(3,4-ethylenedioxythiophene): polystyrene sulfonate (PEDOT:PSS) is an organic mixed ion-electron conducting polymer. The PEDOT phase transports holes and is redox-active, whereas the PSS phase transports ions. When PEDOT is redox-switched between its semiconducting and conducting state, the electronic and optical properties of its bulk are controlled. Therefore, it is appealing to use this transition in electrochemical devices and to integrate those into large-scale circuits, such as display or memory matrices. Addressability and memory functionality of individual devices, within these matrices, are typically achieved by nonlinear current-voltage characteristics and bistability-functions that can potentially be offered by the semiconductor-conductor transition of redox polymers. However, low conductivity of the semiconducting state and poor bistability, due to self-discharge, make fast operation and memory retention impossible. We report that a ferroelectric polymer layer, coated along the counter electrode, can control the redox state of PEDOT. The polarization switching characteristics of the ferroelectric polymer, which take place as the coercive field is overcome, introduce desired nonlinearity and bistability in devices that maintain PEDOT in its highly conducting and fast-operating regime. Memory functionality and addressability are demonstrated in ferro-electrochromic display pixels and ferro-electrochemical transistors.

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  • 27.
    Fabiano, Simone
    et al.
    Linköping University, Sweden.
    Sani, Negar
    Linköping University, Sweden.
    Kawahara, Jun
    RISE - Research Institutes of Sweden, ICT, Acreo. LINTEC Corporation, Japan.
    Kergoat, Loig
    Linköping University, Sweden; Aix-Marseille University, France.
    Nissa, Josefin
    Linköping University, Sweden.
    Engquist, Isak
    Linköping University, Sweden.
    Crispin, Xavier
    Linköping University, Sweden.
    Berggren, Magnus
    Linköping University, Sweden.
    Ferroelectric polarization induces electronic nonlinearity in ion-doped conducting polymers2017Ingår i: Science Advances, E-ISSN 2375-2548, Vol. 3, nr 6, artikel-id e1700345Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) is an organic mixed ion-electron conducting polymer. The PEDOT phase transports holes and is redox-active, whereas the PSS phase transports ions. When PEDOT is redox-switched between its semiconducting and conducting state, the electronic and optical properties of its bulk are controlled. Therefore, it is appealing to use this transition in electrochemical devices and to integrate those into large-scale circuits, such as display or memory matrices. Addressability and memory functionality of individual devices, within these matrices, are typically achieved by nonlinear current-voltage characteristics and bistability—functions that can potentially be offered by the semiconductor-conductor transition of redox polymers. However, low conductivity of the semiconducting state and poor bistability, due to self-discharge, make fast operation and memory retention impossible. We report that a ferroelectric polymer layer, coated along the counter electrode, can control the redox state of PEDOT. The polarization switching characteristics of the ferroelectric polymer, which take place as the coercive field is overcome, introduce desired nonlinearity and bistability in devices that maintain PEDOT in its highly conducting and fast-operating regime. Memory functionality and addressability are demonstrated in ferro-electrochromic display pixels and ferro-electrochemical transistors. 

  • 28.
    Freitas-Dörr, B. C.
    et al.
    Univ Sao Paulo, Inst Quim, Dept Quim Fundamental, BR-05508000 Sao Paulo, SP, Brazil..
    Machado, C. O.
    Univ Sao Paulo, Inst Quim, Dept Quim Fundamental, BR-05508000 Sao Paulo, SP, Brazil..
    Pinheiro, A. C.
    Univ Sao Paulo, Inst Quim, Dept Quim Fundamental, BR-05508000 Sao Paulo, SP, Brazil..
    Fernandes, A. B.
    Univ Sao Paulo, Inst Quim, Dept Quim Fundamental, BR-05508000 Sao Paulo, SP, Brazil..
    Dorr, F. A.
    Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Anal Clin & Toxicol, BR-05508000 Sao Paulo, SP, Brazil..
    Pinto, E.
    Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Anal Clin & Toxicol, BR-05508000 Sao Paulo, SP, Brazil..
    Lopes-Ferreira, M.
    Butantan Inst, Immunoregulat Unit, Special Lab Appl Toxinol, Ctr Toxins Immune Response & Cell Signaling CEPID, BR-05503900 Sao Paulo, SP, Brazil..
    Abdellah, M.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - Ångström, Fysikalisk kemi. South Valley Univ, Qena Fac Sci, Dept Chem, Qena 83523, Egypt..
    Sa, J.
    Uppsala Univ, Dept Chem, Phys Chem Div, Angstrom Lab, S-75120 Uppsala, Sweden.;Polish Acad Sci, Inst Phys Chem, PL-01224 Warsaw, Poland..
    Russo, L. C.
    Univ Sao Paulo, Dept Bioquim, Inst Quim, BR-05508000 Sao Paulo, SP, Brazil..
    Forti, F. L.
    Univ Sao Paulo, Dept Bioquim, Inst Quim, BR-05508000 Sao Paulo, SP, Brazil..
    Goncalves, L. C. P.
    Univ Sao Paulo, Inst Quim, Dept Quim Fundamental, BR-05508000 Sao Paulo, SP, Brazil..
    Bastos, L. L.
    Univ Sao Paulo, Inst Quim, Dept Quim Fundamental, BR-05508000 Sao Paulo, SP, Brazil..
    A metal-free blue chromophore derived from plant pigments2020Ingår i: Science Advances, E-ISSN 2375-2548, Vol. 6, nr 14, artikel-id eaaz0421Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Blue natural pigments are rare, especially among plants. However, flowering species that evolved to attract Hymenoptera pollinators are colored by blue anthocyanin-metal complexes. Plants lacking anthocyanins are pigmented by betalains but are unable to produce blue hues. By extending the pi-system of betalains, we designed a photostable and metal-free blue dye named BeetBlue that did not show toxicity to human hepatic and retinal pigment epithelial cells and does not affect zebrafish embryonal development. This chiral dye can be conveniently synthesized from betalamic acid obtained from hydrolyzed red beetroot juice or by enzymatic oxidation of L-dopa. BeetBlue is blue in the solid form and in solution of acidified polar molecular solvents, including water. Its capacity to dye natural matrices makes BeetBlue the prototype of a new class of low-cost bioinspired chromophores suitable for a myriad of applications requiring a blue hue.

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    FULLTEXT01
  • 29.
    Fulara, H.
    et al.
    Univ Gothenburg, Dept Phys, S-41296 Gothenburg, Sweden..
    Zahedinejad, M.
    Univ Gothenburg, Dept Phys, S-41296 Gothenburg, Sweden.;NanOsc AB, Electrum 229, S-16440 Kista, Sweden..
    Khymyn, R.
    Univ Gothenburg, Dept Phys, S-41296 Gothenburg, Sweden..
    Awad, A. A.
    Univ Gothenburg, Dept Phys, S-41296 Gothenburg, Sweden.;NanOsc AB, Electrum 229, S-16440 Kista, Sweden..
    Muralidhar, S.
    Univ Gothenburg, Dept Phys, S-41296 Gothenburg, Sweden..
    Dvornik, M.
    Univ Gothenburg, Dept Phys, S-41296 Gothenburg, Sweden.;NanOsc AB, Electrum 229, S-16440 Kista, Sweden..
    Åkerman, Johan
    KTH, Skolan för teknikvetenskap (SCI), Tillämpad fysik, Material- och nanofysik. Univ Gothenburg, Dept Phys, S-41296 Gothenburg, Sweden.;NanOsc AB, Electrum 229, S-16440 Kista, Sweden..
    Spin-orbit torque-driven propagating spin waves2019Ingår i: Science Advances, E-ISSN 2375-2548, Vol. 5, nr 9, artikel-id eaax8467Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Spin-orbit torque (SOT) can drive sustained spin wave (SW) auto-oscillations in a class of emerging microwave devices known as spin Hall nano-oscillators (SHNOs), which have highly nonlinear properties governing robust mutual synchronization at frequencies directly amenable to high-speed neuromorphic computing. However, all demonstrations have relied on localized SW modes interacting through dipolar coupling and/or direct exchange. As nanomagnonics requires propagating SWs for data transfer and additional computational functionality can be achieved using SW interference, SOT-driven propagating SWs would be highly advantageous. Here, we demonstrate how perpendicular magnetic anisotropy can raise the frequency of SOT-driven auto-oscillations in magnetic nanoconstrictions well above the SW gap, resulting in the efficient generation of field and current tunable propagating SWs. Our demonstration greatly extends the functionality and design freedom of SHNOs, enabling long-range SOT-driven SW propagation for nanomagnonics, SW logic, and neuromorphic computing, directly compatible with CMOS technology.

  • 30.
    Glemin, Sylvain
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för ekologi och genetik, Växtekologi och evolution. Univ Rennes, CNRS, UMR 6553, ECOBIO Ecosyst Biodiversite Evolut, F-35042 Rennes, France.
    Scornavacca, Celine
    Univ Montpellier, Inst Sci Evolut, CNRS, IRD,EPHE CC 064, Pl Eugene Bataillon, F-34095 Montpellier 05, France.
    Dainat, Jacques
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinsk biokemi och mikrobiologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Burgarella, Concetta
    Univ Montpellier, AGAP, CIRAD, INRA,Montpellier SupAgro, Montpellier, France;CIRAD, UMR AGAP, F-34398 Montpellier, France.
    Viader, Veronique
    Univ Montpellier, AGAP, CIRAD, INRA,Montpellier SupAgro, Montpellier, France.
    Ardisson, Morgane
    Univ Montpellier, AGAP, CIRAD, INRA,Montpellier SupAgro, Montpellier, France.
    Sarah, Gautier
    Univ Montpellier, AGAP, CIRAD, INRA,Montpellier SupAgro, Montpellier, France;INRA, South Green Bioinformat Platform, BIOVERS, CIRAD,IRD,Montpellier SupAgro, Montpellier, France.
    Santoni, Sylvain
    Univ Montpellier, AGAP, CIRAD, INRA,Montpellier SupAgro, Montpellier, France.
    David, Jacques
    Univ Montpellier, AGAP, CIRAD, INRA,Montpellier SupAgro, Montpellier, France.
    Ranwez, Vincent
    Univ Montpellier, AGAP, CIRAD, INRA,Montpellier SupAgro, Montpellier, France.
    Pervasive hybridizations in the history of wheat relatives2019Ingår i: Science Advances, E-ISSN 2375-2548, Vol. 5, nr 5, artikel-id eaav9188Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Cultivated wheats are derived from an intricate history of three genomes, A, B, and D, present in both diploid and polyploid species. It was recently proposed that the D genome originated from an ancient hybridization between the A and B lineages. However, this result has been questioned, and a robust phylogeny of wheat relatives is still lacking. Using transcriptome data from all diploid species and a new methodological approach, our comprehensive phylogenomic analysis revealed that more than half of the species descend from an ancient hybridization event but with a more complex scenario involving a different parent than previously thought-Aegilops mutica, an overlooked wild species-instead of the B genome. We also detected other extensive gene flow events that could explain long-standing controversies in the classification of wheat relatives.

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    fulltext
  • 31.
    Gorbunov, Andrey V.
    et al.
    Eindhoven Univ Technol, Netherlands.
    Iglesias, Miguel Garcia
    Eindhoven Univ Technol, Netherlands.
    Guilleme, Julia
    Univ Autonoma Madrid, Spain.
    Cornelissen, Tim
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Komplexa material och system. Linköpings universitet, Tekniska fakulteten.
    Roelofs, W. S. Christian
    Eindhoven Univ Technol, Netherlands.
    Torres, Tomas
    Univ Autonoma Madrid, Spain; IM DEA Nanociencia, Spain.
    Gonzalez-Rodriguez, David
    Univ Autonoma Madrid, Spain.
    Meijer, E. W.
    Eindhoven Univ Technol, Netherlands.
    Kemerink, Martijn
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Komplexa material och system. Linköpings universitet, Tekniska fakulteten. Eindhoven Univ Technol, Netherlands.
    Ferroelectric self-assembled molecular materials showing both rectifying and switchable conductivity2017Ingår i: Science Advances, ISSN 0036-8156, E-ISSN 2375-2548, Vol. 3, nr 9, artikel-id e1701017Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Advanced molecular materials that combine two or more physical properties are typically constructed by combining different molecules, each being responsible for one of the properties required. Ideally, single molecules could take care of this combined functionality, provided they are self-assembled correctly and endowed with different functional subunits whose strong electronic coupling may lead to the emergence of unprecedented and exciting properties. We present a class of disc-like semiconducting organic molecules that are functionalized with strong dipolar side groups. Supramolecular organization of these materials provides long-range polar order that supports collective ferroelectric behavior of the side groups as well as charge transport through the stacked semiconducting cores. The ferroelectric polarization in these supramolecular polymers is found to couple to the charge transport and leads to a bulk conductivity that is both switchable and rectifying. An intuitive model is developed and found to quantitatively reproduce the experimental observations. In a larger perspective, these results highlight the possibility of modulating material properties using the large electric fields associated with ferroelectric polarization.

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  • 32. Groeneveld, Jeroen
    et al.
    Henderiks, Jorijntje
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Geovetenskapliga sektionen, Institutionen för geovetenskaper, Paleobiologi.
    Renema, Willem
    McHugh, Cecilia M.
    De Vleeschouwer, David
    Christensen, Beth A.
    Fulthorpe, Craig S.
    Reuning, Lars
    Gallagher, Stephen J.
    Bogus, Kara
    Auer, Gerald
    Ishiwa, Takeshige
    Zhang, W. (Medarbetare/bidragsgivare)
    Australian shelf sediments reveal shifts in Miocene Southern Hemisphere westerlies2017Ingår i: Science Advances, ISSN 0036-8156, E-ISSN 2375-2548, Vol. 3, nr 5, artikel-id e1602567Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Global climate underwent a major reorganization when the Antarctic ice sheet expanded ~14 million years ago (Ma) (1). This event affected global atmospheric circulation, including the strength and position of the westerlies and the Intertropical Convergence Zone (ITCZ), and, therefore, precipitation patterns (25). We present new shallow-marine sediment records from the continental shelf of Australia (International Ocean Discovery Program Sites U1459 and U1464) providing the first empirical evidence linking high-latitude cooling around Antarctica to climate change in the (sub)tropics during the Miocene. We show that Western Australia was arid during most of the Middle Miocene. Southwest Australia became wetter during the Late Miocene, creating a climate gradient with the arid interior, whereas northwest Australia remained arid throughout. Precipitation and river runoff in southwest Australia gradually increased from 12 to 8 Ma, which we relate to a northward migration or intensification of the westerlies possibly due to increased sea ice in the Southern Ocean (5). Abrupt aridification indicates that the westerlies shifted back to a position south of Australia after 8 Ma. Our midlatitude Southern Hemisphere data are consistent with the inference that expansion of sea ice around Antarctica resulted in a northward movement of the westerlies. In turn, this may have pushed tropical atmospheric circulation and the ITCZ northward, shifting the main precipitation belt over large parts of Southeast Asia (4).

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  • 33.
    Hill, Jason
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinsk biokemi och mikrobiologi. Stockholm Univ, Dept Zool, Populat Genet, Stockholm, Sweden.
    Rastas, Pasi
    Univ Helsinki, Inst Biotechnol, Helsinki, Finland.
    Hornett, Emily A.
    Univ Cambridge, Dept Zool, Cambridge, England;Univ Liverpool, Inst Integrat Biol, Liverpool, Merseyside, England;Univ Liverpool Liverpool Sch Trop Med, Dept Vector Biol, Liverpool, Merseyside, England.
    Neethiraj, Ramprasad
    Stockholm Univ, Dept Zool, Populat Genet, Stockholm, Sweden.
    Clark, Nathan
    Univ Pittsburgh, Dept Computat & Syst Biol, Pittsburgh, PA 15260 USA.
    Morehouse, Nathan
    Univ Cincinnati, Dept Biol Sci, Cincinnati, OH 45221 USA.
    Celorio-Mancera, Maria de la Paz
    Stockholm Univ, Dept Zool, Populat Genet, Stockholm, Sweden.
    Cols, Jofre Carnicer
    Univ Barcelona, Dept Evolutionary Biol Ecol & Environm Sci, E-08028 Barcelona, Spain;Autonomous Univ Barcelona, Global Ecol Unit, CREAF, Cerdanyola Dell Valles 08193, Spain.
    Dircksen, Heinrich
    Stockholm Univ, Dept Zool, Funct Morphol, Stockholm, Sweden.
    Meslin, Camille
    Univ Pittsburgh, Dept Computat & Syst Biol, Pittsburgh, PA 15260 USA;INRA, Inst Ecol & Environm Sci Paris, Dept Sensory Ecol, Route St Cyr, F-78026 Versailles, France.
    Keehnen, Naomi
    Stockholm Univ, Dept Zool, Populat Genet, Stockholm, Sweden.
    Pruisscher, Peter
    Stockholm Univ, Dept Zool, Populat Genet, Stockholm, Sweden.
    Sikkink, Kristin
    Univ Minnesota, Dept Ecol Evolut & Behav, St Paul, MN 55108 USA;Univ Mississippi, Dept Biol, University, MS 38677 USA.
    Vives, Maria
    Univ Barcelona, Dept Evolutionary Biol Ecol & Environm Sci, E-08028 Barcelona, Spain;Autonomous Univ Barcelona, Global Ecol Unit, CREAF, Cerdanyola Dell Valles 08193, Spain.
    Vogel, Heiko
    Max Planck Inst Chem Ecol, Dept Entomol, D-07745 Jena, Germany.
    Wiklund, Christer
    Stockholm Univ, Dept Zool, Populat Genet, Stockholm, Sweden.
    Woronik, Alyssa
    Stockholm Univ, Dept Zool, Populat Genet, Stockholm, Sweden;NYU, Ctr Dev Genet, Dept Biol, 100 Washington Sq East, New York, NY 10003 USA.
    Boggs, Carol L.
    Univ South Carolina, Dept Biol Sci, Columbia, SC 29208 USA.
    Nylin, Soren
    Stockholm Univ, Dept Zool, Populat Genet, Stockholm, Sweden.
    Wheat, Christopher W.
    Stockholm Univ, Dept Zool, Populat Genet, Stockholm, Sweden.
    Unprecedented reorganization of holocentric chromosomes provides insights into the enigma of lepidopteran chromosome evolution2019Ingår i: Science Advances, E-ISSN 2375-2548, Vol. 5, nr 6, artikel-id eaau3648Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Chromosome evolution presents an enigma in the mega-diverse Lepidoptera. Most species exhibit constrained chromosome evolution with nearly identical haploid chromosome counts and chromosome-level gene collinearity among species more than 140 million years divergent. However, a few species possess radically inflated chromosomal counts due to extensive fission and fusion events. To address this enigma of constraint in the face of an exceptional ability to change, we investigated an unprecedented reorganization of the standard lepidopteran chromosome structure in the green-veined white butterfly (Pieris napi). We find that gene content in P. napi has been extensively rearranged in large collinear blocks, which until now have been masked by a haploid chromosome number close to the lepidopteran average. We observe that ancient chromosome ends have been maintained and collinear blocks are enriched for functionally related genes suggesting both a mechanism and a possible role for selection in determining the boundaries of these genome-wide rearrangements.

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  • 34.
    Hill, Jason
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Zoologiska institutionen, Avdelningen för populationsgenetik. Uppsala University, Sweden.
    Rastas, Pasi
    Hornett, Emily A.
    Neethiraj, Ramprasad
    Stockholms universitet, Naturvetenskapliga fakulteten, Zoologiska institutionen, Avdelningen för populationsgenetik.
    Clark, Nathan
    Morehouse, Nathan
    de la Paz Celorio-Mancera, Maria
    Stockholms universitet, Naturvetenskapliga fakulteten, Zoologiska institutionen, Avdelningen för populationsgenetik.
    Carnicer Cols, Jofre
    Dircksen, Heinrich
    Stockholms universitet, Naturvetenskapliga fakulteten, Zoologiska institutionen, Avdelningen för funktionell zoomorfologi.
    Meslin, Camille
    Keehnen, Naomi
    Stockholms universitet, Naturvetenskapliga fakulteten, Zoologiska institutionen, Avdelningen för populationsgenetik.
    Pruisscher, Peter
    Stockholms universitet, Naturvetenskapliga fakulteten, Zoologiska institutionen, Avdelningen för populationsgenetik.
    Sikkink, Kristin
    Vives, Maria
    Vogel, Heiko
    Wiklund, Christer
    Stockholms universitet, Naturvetenskapliga fakulteten, Zoologiska institutionen, Avdelningen för populationsgenetik.
    Woronik, Alyssa
    Stockholms universitet, Naturvetenskapliga fakulteten, Zoologiska institutionen, Avdelningen för populationsgenetik. New York University, USA.
    Boggs, Carol L.
    Nylin, Sören
    Stockholms universitet, Naturvetenskapliga fakulteten, Zoologiska institutionen, Avdelningen för populationsgenetik.
    Wheat, Christopher W.
    Stockholms universitet, Naturvetenskapliga fakulteten, Zoologiska institutionen, Avdelningen för populationsgenetik.
    Unprecedented reorganization of holocentric chromosomes provides insights into the enigma of lepidopteran chromosome evolution2019Ingår i: Science Advances, E-ISSN 2375-2548, Vol. 5, nr 6, artikel-id eaau3648Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Chromosome evolution presents an enigma in the mega-diverse Lepidoptera. Most species exhibit constrained chromosome evolution with nearly identical haploid chromosome counts and chromosome-level gene collinearity among species more than 140 million years divergent. However, a few species possess radically inflated chromosomal counts due to extensive fission and fusion events. To address this enigma of constraint in the face of an exceptional ability to change, we investigated an unprecedented reorganization of the standard lepidopteran chromosome structure in the green-veined white butterfly (Pieris napi). We find that gene content in P. napi has been extensively rearranged in large collinear blocks, which until now have been masked by a haploid chromosome number close to the lepidopteran average. We observe that ancient chromosome ends have been maintained and collinear blocks are enriched for functionally related genes suggesting both a mechanism and a possible role for selection in determining the boundaries of these genome-wide rearrangements.

  • 35. Hochman, Assaf
    et al.
    Alpert, Pinhas
    Harpaz, Tzvi
    Saaroni, Hadas
    Messori, Gabriele
    Stockholms universitet, Naturvetenskapliga fakulteten, Meteorologiska institutionen (MISU). Uppsala University, Sweden.
    A new dynamical systems perspective on atmospheric predictability: Eastern Mediterranean weather regimes as a case study2019Ingår i: Science Advances, E-ISSN 2375-2548, Vol. 5, nr 6, artikel-id eaau0936Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The atmosphere is a chaotic system displaying recurrent large-scale configurations. Recent developments in dynamical systems theory allow us to describe these configurations in terms of the local dimension-a proxy for the active number of degrees of freedom-and persistence in phase space, which can be interpreted as persistence in time. These properties provide information on the intrinsic predictability of an atmospheric state. Here, this technique is applied to atmospheric configurations in the eastern Mediterranean, grouped into synoptic classifications (SCs). It is shown that local dimension and persistence, derived from reanalysis and CMIP5 models' daily sea-level pressure fields, can serve as an extremely informative qualitative method for evaluating the predictability of the different SCs. These metrics, combined with the SC transitional probability approach, may be a valuable complement to operational weather forecasts and effective tools for climate model evaluation. This new perspective can be extended to other geographical regions.

  • 36.
    Hochman, Assaf
    et al.
    Tel Aviv Univ, Porter Sch Environm & Earth Sci, Dept Geophys, IL-69978 Tel Aviv, Israel;Tel Aviv Univ, Porter Sch Environm & Earth Sci, Dept Geog & Human Environm, IL-69978 Tel Aviv, Israel;Tel Aviv Univ, Porter Sch Environm & Earth Sci, Porter Sch Environm Studies, IL-69978 Tel Aviv, Israel.
    Alpert, Pinhas
    Tel Aviv Univ, Porter Sch Environm & Earth Sci, Dept Geophys, IL-69978 Tel Aviv, Israel.
    Harpaz, Tzvi
    Tel Aviv Univ, Porter Sch Environm & Earth Sci, Dept Geophys, IL-69978 Tel Aviv, Israel;Tel Aviv Univ, Porter Sch Environm & Earth Sci, Dept Geog & Human Environm, IL-69978 Tel Aviv, Israel.
    Saaroni, Hadas
    Tel Aviv Univ, Porter Sch Environm & Earth Sci, Dept Geophys, IL-69978 Tel Aviv, Israel;Tel Aviv Univ, Porter Sch Environm & Earth Sci, Porter Sch Environm Studies, IL-69978 Tel Aviv, Israel.
    Messori, Gabriele
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Geovetenskapliga sektionen, Institutionen för geovetenskaper, Luft-, vatten- och landskapslära. Stockholm Univ, Dept Meteorol, Stockholm, Sweden;Stockholm Univ, Bolin Ctr Climate Res, Stockholm, Sweden.
    A new dynamical systems perspective on atmospheric predictability: Eastern Mediterranean weather regimes as a case study2019Ingår i: Science Advances, E-ISSN 2375-2548, Vol. 5, nr 6, artikel-id eaau0936Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The atmosphere is a chaotic system displaying recurrent large-scale configurations. Recent developments in dynamical systems theory allow us to describe these configurations in terms of the local dimension-a proxy for the active number of degrees of freedom-and persistence in phase space, which can be interpreted as persistence in time. These properties provide information on the intrinsic predictability of an atmospheric state. Here, this technique is applied to atmospheric configurations in the eastern Mediterranean, grouped into synoptic classifications (SCs). It is shown that local dimension and persistence, derived from reanalysis and CMIP5 models' daily sea-level pressure fields, can serve as an extremely informative qualitative method for evaluating the predictability of the different SCs. These metrics, combined with the SC transitional probability approach, may be a valuable complement to operational weather forecasts and effective tools for climate model evaluation. This new perspective can be extended to other geographical regions.

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    FULLTEXT01
  • 37.
    Hoshino, Yosuke
    et al.
    Max Planck Inst Biogeochem, Hans Knoell Str 10, D-07745 Jena, Germany.;Georgia Inst Technol, Sch Biol Sci, 950 Atlantic Dr Northwest, Atlanta, GA 30332 USA..
    Poshibaeva, Aleksandra
    Gubkin Russian State Univ Oil & Gas, Leninsky Prospekt 65, Moscow, Russia..
    Meredith, William
    Univ Nottingham, Fac Engn, Energy Technol Bldg,Triumph Rd, Nottingham NG7 2TU, England..
    Snape, Colin
    Univ Nottingham, Fac Engn, Energy Technol Bldg,Triumph Rd, Nottingham NG7 2TU, England..
    Poshibaev, Vladimir
    Gubkin Russian State Univ Oil & Gas, Leninsky Prospekt 65, Moscow, Russia..
    Versteegh, Gerard J. M.
    Univ Bremen, MARUM Ctr Marine Environm Sci, Leobener Str 8, D-28359 Bremen, Germany.;Helmholtz Zentrum Polar & Meeresforsch, Alfred Wegener Inst, Handelshafen 12, D-27570 Bremerhaven, Germany..
    Kuznetsov, Nikolay
    Gubkin Russian State Univ Oil & Gas, Leninsky Prospekt 65, Moscow, Russia.;Russian Acad Sci, Geol Inst, Pygevsky 7, Moscow, Russia..
    Leider, Arne
    Max Planck Inst Biogeochem, Hans Knoell Str 10, D-07745 Jena, Germany..
    van Maldegem, Lennart
    Max Planck Inst Biogeochem, Hans Knoell Str 10, D-07745 Jena, Germany.;Univ Bremen, MARUM Ctr Marine Environm Sci, Leobener Str 8, D-28359 Bremen, Germany..
    Neumann, Mareike
    Max Planck Inst Biogeochem, Hans Knoell Str 10, D-07745 Jena, Germany..
    Naeher, Sebastian
    Max Planck Inst Biogeochem, Hans Knoell Str 10, D-07745 Jena, Germany.;Univ Bremen, MARUM Ctr Marine Environm Sci, Leobener Str 8, D-28359 Bremen, Germany.;GNS Sci, 1 Fairway Dr, Lower Hutt 5010, New Zealand..
    Moczydlowska-Vidal, Malgorzata
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Geovetenskapliga sektionen, Institutionen för geovetenskaper, Paleobiologi.
    Brocks, Jochen J.
    Australian Natl Univ, Res Sch Earth Sci, Bldg 142,Mills Rd, Canberra, ACT 2601, Australia..
    Jarrett, Amber J. M.
    Australian Natl Univ, Res Sch Earth Sci, Bldg 142,Mills Rd, Canberra, ACT 2601, Australia..
    Tang, Qing
    Virginia Tech, Dept Geosci, Blacksburg, VA 24061 USA..
    Xiao, Shuhai
    Virginia Tech, Dept Geosci, Blacksburg, VA 24061 USA..
    McKirdy, David
    Univ Adelaide, Dept Earth Sci, Adelaide, SA 5005, Australia..
    Das, Supriyo Kumar
    Presidency Univ, Dept Geol, Coll St 86-1, Kolkata 700073, India..
    Alvaro, Jose Javier
    Univ Complutense Madrid, CSIC, Inst Geoci, Novais 12, E-28040 Madrid, Spain..
    Sansjofre, Pierre
    Univ Bretagne Occidentale, UMR CNRS 6538, Lab Geosci Ocean, F-29280 Plouzane, France..
    Hallmann, Christian
    Max Planck Inst Biogeochem, Hans Knoell Str 10, D-07745 Jena, Germany.;Univ Bremen, MARUM Ctr Marine Environm Sci, Leobener Str 8, D-28359 Bremen, Germany..
    Cryogenian evolution of stigmasteroid biosynthesis2017Ingår i: Science Advances, ISSN 0036-8156, E-ISSN 2375-2548, Vol. 3, nr 9, artikel-id e1700887Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Sedimentary hydrocarbon remnants of eukaryotic C-26-C-30 sterols can be used to reconstruct early algal evolution. Enhanced C-29 sterol abundances provide algal cellmembranes a density advantage in large temperature fluctuations. Here, we combined a literature review with new analyses to generate a comprehensive inventory of unambiguously syngenetic steranes in Neoproterozoic rocks. Our results show that the capacity for C-29 24ethyl- sterol biosynthesis emerged in the Cryogenian, that is, between 720 and 635 million years ago during the Neoproterozoic Snowball Earth glaciations, which were an evolutionary stimulant, not a bottleneck. This biochemical innovation heralded the rise of green algae to global dominance of marine ecosystems and highlights the environmental drivers for the evolution of sterol biosynthesis. The Cryogenian emergence of C-29 sterol biosynthesis places benchmark for verifying older sterane signatures and sets a new framework for our understanding of early algal evolution.

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    fulltext
  • 38.
    Iwamoto, Hideki
    et al.
    Karolinska Inst, Sweden.
    Zhang, Yin
    Karolinska Inst, Sweden.
    Seki, Takahiro
    Karolinska Inst, Sweden.
    Yang, Yunlong
    Karolinska Inst, Sweden.
    Nakamura, Masaki
    Karolinska Inst, Sweden.
    Wang, Jian
    Karolinska Inst, Sweden.
    Yang, Xiaojuan
    Karolinska Inst, Sweden; Tongji Univ, Peoples R China.
    Torimura, Takuji
    Kurume Univ, Japan.
    Cao, Yihai
    Linköpings universitet, Institutionen för medicin och hälsa. Linköpings universitet, Medicinska fakulteten. Karolinska Inst, Sweden; Univ Leicester, England; Glenfield Hosp, England.
    PlGF-induced VEGFR1-dependent vascular remodeling determines opposing antitumor effects and drug resistance to Dll4-Notch inhibitors2015Ingår i: Science Advances, ISSN 0036-8156, E-ISSN 2375-2548, Vol. 1, nr 3, artikel-id e1400244Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Inhibition of Dll4 (delta-like ligand 4)-Notch signaling-mediated tumor angiogenesis is an attractive approach in cancer therapy. However, inhibition of Dll4-Notch signaling has produced different effects in various tumors, and no biomarkers are available for predicting the anti-Dll4-Notch-associated antitumor activity. We show that human and mouse tumor cell-derived placental growth factor (PlGF) is a key determinant of the Dll4-Notch-induced vascular remodeling and tumor growth. In natural PlGF-expressing human tumors, inhibition of Dll4-Notch signaling markedly accelerated tumor growth by increasing blood perfusion in nonleaking tumor vasculatures. Conversely, in PlGF-negative tumors, Dll4 inhibition suppressed tumor growth by the formation of nonproductive and leaky vessels. Surprisingly, genetic inactivation of vascular endothelial growth factor receptor 1 (VEGFR1) completely abrogated the PlGF-modulated vascular remodeling and tumor growth, indicating a crucial role for VEGFR1-mediated signals in modulating Dll4-Notch functions. These findings provide mechanistic insights on PlGF-VEGFR1 signaling in the modulation of the Dll4-Notch pathway in angiogenesis and tumor growth, and have therapeutic implications of PlGF as a biomarker for predicting the antitumor benefits of Dll4 and Notch inhibitors.

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  • 39.
    Jakesova, Marie
    et al.
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Laboratoriet för organisk elektronik. Linköpings universitet, Tekniska fakulteten.
    Silverå Ejneby, Malin
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelning för neurobiologi. Linköpings universitet, Medicinska fakulteten.
    Derek, Vedran
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Laboratoriet för organisk elektronik. Linköpings universitet, Tekniska fakulteten.
    Schmidt, Tony
    Med Univ Graz, Austria.
    Gryszel, Maciej
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Laboratoriet för organisk elektronik. Linköpings universitet, Tekniska fakulteten.
    Brask, Johan
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelning för neurobiologi. Linköpings universitet, Medicinska fakulteten.
    Schindl, Rainer
    Med Univ Graz, Austria.
    Simon, Daniel
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Laboratoriet för organisk elektronik. Linköpings universitet, Tekniska fakulteten.
    Berggren, Magnus
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Laboratoriet för organisk elektronik. Linköpings universitet, Tekniska fakulteten.
    Elinder, Fredrik
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelning för neurobiologi. Linköpings universitet, Medicinska fakulteten.
    Glowacki, Eric
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Laboratoriet för organisk elektronik. Linköpings universitet, Tekniska fakulteten.
    Optoelectronic control of single cells using organic photocapacitors2019Ingår i: Science Advances, E-ISSN 2375-2548, Vol. 5, nr 4, artikel-id eaav5265Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Optical control of the electrophysiology of single cells can be a powerful tool for biomedical research and technology. Here, we report organic electrolytic photocapacitors (OEPCs), devices that function as extracellular capacitive electrodes for stimulating cells. OEPCs consist of transparent conductor layers covered with a donor-acceptor bilayer of organic photoconductors. This device produces an open-circuit voltage in a physiological solution of 330 mV upon illumination using light in a tissue transparency window of 630 to 660 nm. We have performed electrophysiological recordings on Xenopus laevis oocytes, finding rapid (time constants, 50 mu s to 5 ms) photoinduced transient changes in the range of 20 to 110 mV. We measure photoinduced opening of potassium channels, conclusively proving that the OEPC effectively depolarizes the cell membrane. Our results demonstrate that the OEPC can be a versatile nongenetic technique for optical manipulation of electrophysiology and currently represents one of the simplest and most stable and efficient optical stimulation solutions.

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    fulltext
  • 40.
    Jemth, Per
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinsk biokemi och mikrobiologi.
    Karlsson, Elin
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinsk biokemi och mikrobiologi.
    Vogeli, Beat
    Univ Colorado Denver, Dept Biochem & Mol Genet, 12801 East 17th Ave, Aurora, CO 80045 USA.
    Guzovsky, Brenda
    Univ Buenos Aires, IQUIBICEN CONICET, FCEyN, Prot Physiol Lab, Intendente Guiraldes 2160,Ciudad Univ,C1428EGA, Buenos Aires, DF, Argentina.
    Andersson, Eva
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinsk biokemi och mikrobiologi.
    Hultqvist, Greta
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för farmaceutisk biovetenskap.
    Dogan, Jakob
    Stockholm Univ, Dept Biochem & Biophys, SE-10691 Stockholm, Sweden.
    Guntert, Peter
    Swiss Fed Inst Technol, Lab Phys Chem, ETH Honggerberg, Zurich, Switzerland;Goethe Univ, Ctr Biomol Magnet Resonance, Inst Biophys Chem, D-60438 Frankfurt, Germany;Tokyo Metropolitan Univ, Grad Sch Sci, Tokyo 1920397, Japan.
    Riek, Roland
    Swiss Fed Inst Technol, Lab Phys Chem, ETH Honggerberg, Zurich, Switzerland.
    Chi, Celestine N.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinsk biokemi och mikrobiologi.
    Structure and dynamics conspire in the evolution of affinity between intrinsically disordered proteins2018Ingår i: Science Advances, E-ISSN 2375-2548, Vol. 4, nr 10, artikel-id eaau4130Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    In every established species, protein-protein interactions have evolved such that they are fit for purpose. However, the molecular details of the evolution of new protein-protein interactions are poorly understood. We have used nuclear magnetic resonance spectroscopy to investigate the changes in structure and dynamics during the evolution of a protein-protein interaction involving the intrinsically disordered CREBBP (CREB-binding protein) interaction domain (CID) and nuclear coactivator binding domain (NCBD) from the transcriptional coregulators NCOA (nuclear receptor coactivator) and CREBBP/p300, respectively. The most ancient low-affinity "Cambrian-like" [540 to 600 million years (Ma) ago] CID/NCBD complex contained less secondary structure and was more dynamic than the complexes from an evolutionarily younger "Ordovician-Silurian" fish ancestor (ca. 440 Ma ago) and extant human. The most ancient Cambrian-like CID/NCBD complex lacked one helix and several interdomain interactions, resulting in a larger solvent-accessible surface area. Furthermore, the most ancient complex had a high degree of millisecond-to-microsecond dynamics distributed along the entire sequences of both CID and NCBD. These motions were reduced in the Ordovician-Silurian CID/NCBD complex and further redistributed in the extant human CID/NCBD complex. Isothermal calorimetry experiments show that complex formation is enthalpically favorable and that affinity is modulated by a largely unfavorable entropic contribution to binding. Our data demonstrate how changes in structure and motion conspire to shape affinity during the evolution of a protein-protein complex and provide direct evidence for the role of structural, dynamic, and frustrational plasticity in the evolution of interactions between intrinsically disordered proteins.

  • 41. Jemth, Per
    et al.
    Karlsson, Elin
    Vögeli, Beat
    Guzovsky, Brenda
    Andersson, Eva
    Hultqvist, Greta
    Dogan, Jakob
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för biokemi och biofysik.
    Güntert, Peter
    Riek, Roland
    Chi, Celestine N.
    Structure and dynamics conspire in the evolution of affinity between intrinsically disordered proteins2018Ingår i: Science Advances, E-ISSN 2375-2548, Vol. 4, nr 10, artikel-id eaau4130Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    In every established species, protein-protein interactions have evolved such that they are fit for purpose. However, the molecular details of the evolution of new protein-protein interactions are poorly understood. We have used nuclear magnetic resonance spectroscopy to investigate the changes in structure and dynamics during the evolution of a protein-protein interaction involving the intrinsically disordered CREBBP (CREB-binding protein) interaction domain (CID) and nuclear coactivator binding domain (NCBD) from the transcriptional coregulators NCOA (nuclear receptor coactivator) and CREBBP/p300, respectively. The most ancient low-affinity Cambrian-like [540 to 600 million years (Ma) ago] CID/NCBD complex contained less secondary structure and was more dynamic than the complexes from an evolutionarily younger Ordovician-Silurian fish ancestor (ca. 440 Ma ago) and extant human. The most ancient Cambrian-like CID/NCBD complex lacked one helix and several interdomain interactions, resulting in a larger solvent-accessible surface area. Furthermore, the most ancient complex had a high degree of millisecond-to-microsecond dynamics distributed along the entire sequences of both CID and NCBD. These motions were reduced in the Ordovician-Silurian CID/NCBD complex and further redistributed in the extant human CID/NCBD complex. Isothermal calorimetry experiments show that complex formation is enthalpically favorable and that affinity is modulated by a largely unfavorable entropic contribution to binding. Our data demonstrate how changes in structure and motion conspire to shape affinity during the evolution of a protein-protein complex and provide direct evidence for the role of structural, dynamic, and frustrational plasticity in the evolution of interactions between intrinsically disordered proteins.

  • 42. Jiguet, Frederic
    et al.
    Robert, Alexandre
    Lorrilliere, Romain
    Hobson, Keith A.
    Kardynal, Kevin J.
    Arlettaz, Raphael
    Bairlein, Franz
    Belik, Viktor
    Bernardy, Petra
    Copete, Jose Luis
    Czajkowski, Michel Alexandre
    Dale, Svein
    Dombrovski, Valery
    Ducros, Delphine
    Efrat, Ron
    Elts, Jaanus
    Ferrand, Yves
    Marja, Riho
    Minkevicius, Simonas
    Olsson, Peter
    Perez, Marc
    Piha, Markus
    Rakovic, Marko
    Schmaljohann, Heiko
    Seimola, Tuomas
    Selstam, Gunnar
    Umeå universitet, Medicinska fakulteten, Institutionen för molekylärbiologi (Medicinska fakulteten). Department of Agricultural Research in Northern Sweden, Swedish University of Agricultural Sciences, Sweden.
    Siblet, Jean-Philippe
    Skierczynski, Michal
    Sokolov, Alexandr
    Sondell, Jan
    Moussy, Caroline
    Unravelling migration connectivity reveals unsustainable hunting of the declining ortolan bunting2019Ingår i: Science Advances, E-ISSN 2375-2548, Vol. 5, nr 5, artikel-id eaau2642Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    In France, illegal hunting of the endangered ortolan bunting Emberiza hortulana has been defended for the sake of tradition and gastronomy. Hunters argued that ortolan buntings trapped in southwest France originate from large and stable populations across the whole of Europe. Yet, the European Commission referred France to the Court of Justice of the European Union (EU) in December 2016 for infringements to legislation (IP/16/4213). To better assess the impact of hunting in France, we combined Pan-European data from archival light loggers, stable isotopes, and genetics to determine the migration strategy of the species across continents. Ortolan buntings migrating through France come from northern and western populations, which are small, fragmented and declining. Population viability modeling further revealed that harvesting in southwest France is far from sustainable and increases extinction risk. These results provide the sufficient scientific evidence for justifying the ban on ortolan harvesting in France.

  • 43. Jogenfors, Jonathan
    et al.
    Elhassan, Ashraf Mohamed
    Stockholms universitet, Naturvetenskapliga fakulteten, Fysikum.
    Ahrens, Johan
    Stockholms universitet, Naturvetenskapliga fakulteten, Fysikum.
    Bourennane, Mohamed
    Stockholms universitet, Naturvetenskapliga fakulteten, Fysikum.
    Larsson, Jan-Åke
    Hacking the Bell test using classical light in energy-time entanglement-based quantum key distribution2015Ingår i: Science Advances, E-ISSN 2375-2548, Vol. 1, nr 11, artikel-id e1500793Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Photonic systems based on energy-time entanglement have been proposed to test local realism using the Bell inequality. A violation of this inequality normally also certifies security of device-independent quantum key distribution (QKD) so that an attacker cannot eavesdrop or control the system. We show how this security test can be circumvented in energy-time entangled systems when using standard avalanche photodetectors, allowing an attacker to compromise the system without leaving a trace. We reach Bell values up to 3.63 at 97.6% faked detector efficiency using tailored pulses of classical light, which exceeds even the quantum prediction. This is the first demonstration of a violation-faking source that gives both tunable violation and high faked detector efficiency. The implications are severe: the standard Clauser-Horne-Shimony-Holt inequality cannot be used to show device-independent security for energy-time entanglement setups based on Franson's configuration. However, device-independent security can be reestablished, and we conclude by listing a number of improved tests and experimental setups that would protect against all current and future attacks of this type.

  • 44.
    Jonsson, A.
    et al.
    Linköping University, Sweden.
    Song, Z.
    Karolinska Institutet, Sweden.
    Nilsson, David
    RISE., Swedish ICT, Acreo.
    Meyerson, B. A.
    Karolinska Institutet, Sweden.
    Simon, D. T.
    Linköping University, Sweden.
    Linderoth, B.
    Karolinska Institutet, Sweden.
    Berggren, M.
    Linköping University, Sweden.
    Therapy using implanted organic bioelectronics2015Ingår i: Science Advances, E-ISSN 2375-2548, Vol. 1, nr 4, artikel-id 1500039Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Many drugs provide their therapeutic action only at specific sites in the body, but are administered in ways that cause the drug’s spread throughout the organism. This can lead to serious side effects. Local delivery from an implanted device may avoid these issues, especially if the delivery rate can be tuned according to the need of the patient. We turned to electronically and ionically conducting polymers to design a device that could be implanted and used for local electrically controlled delivery of therapeutics. The conducting polymers in our device allow electronic pulses to be transduced into biological signals, in the form of ionic and molecular fluxes, which provide a way of interfacing biology with electronics. Devices based on conducting polymers and polyelectrolytes have been demonstrated in controlled substance delivery to neural tissue, biosensing, and neural recording and stimulation. While providing proof of principle of bioelectronic integration, such demonstrations have been performed in vitro or in anesthetized animals. Here, we demonstrate the efficacy of an implantable organic electronic delivery device for the treatment of neuropathic pain in an animal model. Devices were implanted onto the spinal cord of rats, and 2 days after implantation, local delivery of the inhibitory neurotransmitter g-aminobutyric acid (GABA) was initiated. Highly localized delivery resulted in a significant decrease in pain response with low dosage and no observable side effects. This demonstration of organic bioelectronics-based therapy in awake animals illustrates a viable alternative to existing pain treatments, paving the way for future implantable bioelectronic therapeutics. 2015 © The Authors.

  • 45.
    Jouffray, Jean-Baptiste
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Stockholm Resilience Centre. Royal Swedish Academy of Sciences, Sweden.
    Crona, Beatrice
    Stockholms universitet, Naturvetenskapliga fakulteten, Stockholm Resilience Centre. Royal Swedish Academy of Sciences, Sweden.
    Wassénius, Emmy
    Stockholms universitet, Naturvetenskapliga fakulteten, Stockholm Resilience Centre. Royal Swedish Academy of Sciences, Sweden.
    Bebbington, Jan
    Scholtens, Bert
    Leverage points in the financial sector for seafood sustainability2019Ingår i: Science Advances, E-ISSN 2375-2548, Vol. 5, nr 10, artikel-id eaax3324Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Can finance contribute to seafood sustainability? This is an increasingly relevant question given the projected growth of seafood markets and the magnitude of social and environmental challenges associated with seafood production. As more capital enters the seafood industry, it becomes crucial that investments steer the sector toward improved sustainability, as opposed to fueling unsustainable working conditions and overexploitation of resources. Using a mixed-methods approach, we map where different financial mechanisms are most salient along a seafood firm's development trajectory and identify three leverage points that can redirect capital toward more sustainable practices: loan covenants, stock exchange listing rules, and shareholder activism. We argue that seafood sustainability requirements need to be integrated into traditional financial services and propose key research avenues for academic, policy, and practice communities. While our study focuses on the role of finance in seafood sustainability, the insights developed are also of high relevance to other extractive industries.

  • 46.
    Keuschnigg, Marc
    et al.
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Institutet för analytisk sociologi, IAS. Linköpings universitet, Filosofiska fakulteten.
    Mutgan, Selcan
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Institutet för analytisk sociologi, IAS. Linköpings universitet, Filosofiska fakulteten.
    Hedström, Peter
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Institutet för analytisk sociologi, IAS. Linköpings universitet, Filosofiska fakulteten.
    Urban scaling and the regional divide2019Ingår i: Science Advances, E-ISSN 2375-2548, Vol. 5, nr 1, artikel-id eaav0042Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Superlinear growth in cities has been explained as an emergent consequence of increased social interactions in dense urban environments. Using geocoded microdata from Swedish population registers, we remove population composition effects from the scaling relation of wage income to test how much of the previously reported superlinear scaling is truly attributable to increased social interconnectivity in cities. The Swedish data confirm the previously reported scaling relations on the aggregate level, but they provide better information on the micromechanisms responsible for them. We find that the standard interpretation of urban scaling is incomplete as social interactions only explain about half of the scaling parameter of wage income and that scaling relations substantively reflect differences in cities sociodemographic composition. Those differences are generated by selective migration of highly productive individuals into larger cities. Big cities grow through their attraction of talent from their hinterlands and the already-privileged benefit disproportionally from urban agglomeration.

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  • 47.
    Krzewinska, Maja
    et al.
    Stockholm Univ, Dept Archaeol & Class Studies, Archaeol Res Lab, Lilla Frescativagen 7, SE-10691 Stockholm, Sweden.
    Kilinc, Gulsah Merve
    Stockholm Univ, Dept Archaeol & Class Studies, Archaeol Res Lab, Lilla Frescativagen 7, SE-10691 Stockholm, Sweden.
    Juras, Anna
    Adam Mickiewicz Univ, Fac Biol, Inst Anthropol, Dept Human Evolutionary Biol, Umultowska 89, PL-61614 Poznan, Poland.
    Koptekin, Dilek
    Middle East Tech Univ, Dept Hlth Informat, TR-06800 Ankara, Turkey.
    Chylenski, Maciej
    Adam Mickiewicz Univ, Fac Hist, Inst Archaeol, Umultowska 89D, PL-61614 Poznan, Poland.
    Nikitin, Alexey G.
    Grand Valley State Univ, Biol Dept, 1 Campus Dr, Allendale, MI 49401 USA.
    Shcherbakov, Nikolai
    Bashkir State Pedag Univ, Lab Methodol & Methods Humanitarian Res, Octyabrskoy Revolutsii 3A, Ufa 450007, Russia.
    Shuteleva, Iia
    Bashkir State Pedag Univ, Lab Methodol & Methods Humanitarian Res, Octyabrskoy Revolutsii 3A, Ufa 450007, Russia;Bashkir State Univ, Inst Hist & State Management, Zaki Validy St 32, Ufa 450076, Russia.
    Leonova, Tatiana
    Bashkir State Pedag Univ, Lab Methodol & Methods Humanitarian Res, Octyabrskoy Revolutsii 3A, Ufa 450007, Russia.
    Kraeva, Liudmila
    Orenburg State Pedag Univ, Archaeol Lab, Orenburg, Russia.
    Sungatov, Flarit A.
    Bashkir State Univ, Archaeol Lab, Str Validi Z 32, Ufa, Russia.
    Sultanova, Alfija N.
    Bashkir State Univ, Archaeol Lab, Str Validi Z 32, Ufa, Russia.
    Potekhina, Inna
    Natl Acad Sci Ukraine, Inst Archaeol, Kiev, Ukraine.
    Lukasik, Sylwia
    Adam Mickiewicz Univ, Fac Biol, Inst Anthropol, Dept Human Evolutionary Biol, Umultowska 89, PL-61614 Poznan, Poland.
    Krenz-Niedbala, Marta
    Adam Mickiewicz Univ, Fac Biol, Inst Anthropol, Dept Human Evolutionary Biol, Umultowska 89, PL-61614 Poznan, Poland.
    Dalen, Love
    Swedish Museum Nat Hist, Dept Bioinformat & Genet, POB 50007, S-10405 Stockholm, Sweden.
    Sinika, Vitaly
    Taras Shevchenko Univ Tiraspol, October St 25, Tiraspol 3300, Moldova;Nizhnevartovsk State Univ, Lenin St 56, Khanty Mansi Autonomous 628605, Yugra, Russia.
    Jakobsson, Mattias
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Människans evolution. Uppsala universitet, Science for Life Laboratory, SciLifeLab. Univ Johannesburg, Ctr Anthropol Res, POB 524, ZA-2006 Auckland Pk, South Africa;Univ Johannesburg, Dept Anthropol & Dev Studies, POB 524, ZA-2006 Auckland Pk, South Africa.
    Stora, Jan
    Stockholm Univ, Dept Archaeol & Classical Studies, Osteoarchaeol Res Lab, Lilla Frescativagen 7, SE-10691 Stockholm, Sweden.
    Gotherstrom, Anders
    Stockholm Univ, Dept Archaeol & Class Studies, Archaeol Res Lab, Lilla Frescativagen 7, SE-10691 Stockholm, Sweden.
    Ancient genomes suggest the eastern Pontic-Caspian steppe as the source of western Iron Age nomads2018Ingår i: Science Advances, E-ISSN 2375-2548, Vol. 4, nr 10, artikel-id eaat4457Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    For millennia, the Pontic-Caspian steppe was a connector between the Eurasian steppe and Europe. In this scene, multidirectional and sequential movements of different populations may have occurred, including those of the Eurasian steppe nomads. We sequenced 35 genomes (low to medium coverage) of Bronze Age individuals (Srubnaya-Alakulskaya) and Iron Age nomads (Cimmerians, Scythians, and Sarmatians) that represent four distinct cultural entities corresponding to the chronological sequence of cultural complexes in the region. Our results suggest that, despite genetic links among these peoples, no group can be considered a direct ancestor of the subsequent group. The nomadic populations were heterogeneous and carried genetic affinities with populations from several other regions including the Far East and the southern Urals. We found evidence of a stable shared genetic signature, making the eastern Pontic-Caspian steppe a likely source of western nomadic groups.

  • 48. Krzewinska, Maja
    et al.
    Kilinc, Gulsah Merve
    Juras, Anna
    Koptekin, Dilek
    Chylenski, Maciej
    Nikitin, Alexey G.
    Shcherbakov, Nikolai
    Shuteleva, Iia
    Leonova, Tatiana
    Kraeva, Liudmila
    Sungatov, Flarit A.
    Sultanova, Alfija N.
    Potekhina, Inna
    Lukasik, Sylwia
    Krenz-Niedbala, Marta
    Dalén, Love
    Naturhistoriska riksmuseet, Enheten för bioinformatik och genetik.
    Sinika, Vitaly
    Jakobsson, Mattias
    Stora, Jan
    Gotherstrom, Anders
    Ancient genomes suggest the eastern Pontic-Caspian steppe as the source of western Iron Age nomads2018Ingår i: Science Advances, E-ISSN 2375-2548, Vol. 4, nr 10, artikel-id eaat4457Artikel i tidskrift (Refereegranskat)
  • 49.
    Krzewińska, Maja
    et al.
    Stockholms universitet, Humanistiska fakulteten, Institutionen för arkeologi och antikens kultur.
    Kılınç, Gülşah Merve
    Stockholms universitet, Humanistiska fakulteten, Institutionen för arkeologi och antikens kultur.
    Juras, Anna
    Koptekin, Dilek
    Chylenski, Maciej
    Nikitin, Alexey G.
    Shcherbakov, Nikolai
    Shuteleva, Iia
    Leonova, Tatiana
    Kraeva, Liudmila
    Sungatov, Flarit A.
    Sultanova, Alfija N.
    Potekhina, Inna
    Łukasik, Sylwia
    Krenz-Niedbała, Marta
    Dalén, Love
    Sinika, Vitaly
    Jakobsson, Mattias
    Storå, Jan
    Stockholms universitet, Humanistiska fakulteten, Institutionen för arkeologi och antikens kultur.
    Götherström, Anders
    Stockholms universitet, Humanistiska fakulteten, Institutionen för arkeologi och antikens kultur.
    Ancient genomes suggest the eastern Pontic-Caspian steppe as the source of western Iron Age nomads2018Ingår i: Science Advances, E-ISSN 2375-2548, Vol. 4, nr 10, artikel-id eaat4457Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    For millennia, the Pontic-Caspian steppe was a connector between the Eurasian steppe and Europe. In this scene, multidirectional and sequential movements of different populations may have occurred, including those of the Eurasian steppe nomads. We sequenced 35 genomes (low to medium coverage) of Bronze Age individuals (Srubnaya-Alakulskaya) and Iron Age nomads (Cimmerians, Scythians, and Sarmatians) that represent four distinct cultural entities corresponding to the chronological sequence of cultural complexes in the region. Our results suggest that, despite genetic links among these peoples, no group can be considered a direct ancestor of the subsequent group. The nomadic populations were heterogeneous and carried genetic affinities with populations from several other regions including the Far East and the southern Urals. We found evidence of a stable shared genetic signature, making the eastern Pontic-Caspian steppe a likely source of western nomadic groups.

  • 50. Kuang Soh, Wuu
    et al.
    Yiotis, Charilaos
    Murray, Michelle
    Parnell, Andrew
    Wright, Ian J.
    Spicer, Robert A.
    Lawson, Tracy
    Caballero, Rodrigo
    Stockholms universitet, Naturvetenskapliga fakulteten, Meteorologiska institutionen (MISU).
    McElwain, Jennifer C.
    Rising CO2 drives divergence in water use efficiency of evergreen and deciduous plants2019Ingår i: Science Advances, E-ISSN 2375-2548, Vol. 5, nr 12, artikel-id eaax7906Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Intrinsic water use efficiency (iWUE), defined as the ratio of photosynthesis to stomatal conductance, is a key variable in plant physiology and ecology. Yet, how rising atmospheric CO2 concentration affects iWUE at broad species and ecosystem scales is poorly understood. In a field-based study of 244 woody angiosperm species across eight biomes over the past 25 years of increasing atmospheric CO2 (similar to 45 ppm), we show that iWUE in evergreen species has increased more rapidly than in deciduous species. Specifically, the difference in iWUE gain between evergreen and deciduous taxa diverges along a mean annual temperature gradient from tropical to boreal forests and follows similar observed trends in leaf functional traits such as leaf mass per area. Synthesis of multiple lines of evidence supports our findings. This study provides timely insights into the impact of Anthropocene climate change on forest ecosystems and will aid the development of next-generation trait-based vegetation models.

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