Digitala Vetenskapliga Arkivet

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  • 1.
    Chen, Song
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    Cai, Yixiao
    Engqvist, Håkan
    Xia, Wei
    Controlling bioactivity of glass ionomer cement by incorporating calcium silicatesIn: Biomatter, ISSN 2159-2527, E-ISSN 2159-2535Article in journal (Refereed)
    Abstract
  • 2.
    Chen, Song
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Cai, Yixiao
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Engqvist, Håkan
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Xia, Wei
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Enhanced bioactivity of glass ionomer cement by incorporating calcium silicates2016In: Biomatter, ISSN 2159-2527, E-ISSN 2159-2535, Vol. 6, p. e1123842-Article in journal (Refereed)
  • 3.
    Chen, Song
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Cai, Yixiao
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Engqvist, Håkan
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Xia, Wei
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Enhanced bioactivity of glass ionomer cement by incorporating calcium silicates2016In: Biomatter, ISSN 2159-2527, E-ISSN 2159-2535, Vol. 6, no 1, p. e1123842-1-e1123842-13Article in journal (Refereed)
  • 4.
    Olofsson, Johanna
    et al.
    Applied Materials Science, Uppsala University, Sweden.
    Grehk, Mikael
    Sandvik Materials Technology; Sandviken, Sweden.
    Berlind, Torun
    Linköping University, Department of Physics, Chemistry and Biology, Applied Optics . Linköping University, The Institute of Technology.
    Persson, Cecilia
    Applied Materials Science, Uppsala University, Sweden.
    Jacobson, Staffan
    Applied Materials Science, Uppsala University, Sweden.
    Engqvist, Håkan
    Applied Materials Science, Uppsala University, Sweden.
    Evaluation of silicon nitride as a wear resistant and resorbable alternative for total hip joint replacement2012In: Biomatter, ISSN 2159-2527, E-ISSN 2159-2535, Vol. 2, no 2, p. 94-102Article in journal (Refereed)
    Abstract [en]

    Many of the failures of total joint replacements are related to tribology, i.e., wear of the cup, head and liner. Accumulation of wear particles at the implants can be linked to osteolysis which leads to bone loss and in the end aseptic implant loosening. Therefore it is highly desirable to reduce the generation of wear particles from the implant surfaces.

    Silicon nitride (Si3N4) has shown to be biocompatible and have a low wear rate when sliding against itself and is therefore a good candidate as a hip joint material. Furthermore, wear particles of Si3N4 are predicted to slowly dissolve in polar liquids and they therefore have the potential to be resorbed in vivo, potentially reducing the risk for aseptic loosening.

    In this study, it was shown that α-Si3N4-powder dissolves in PBS. Adsorption of blood plasma indicated a good acceptance of Si3N4 in the body with relatively low immune response. Si3N4 sliding against Si3N4 showed low wear rates both in bovine serum and PBS compared with the other tested wear couples. Tribofilms were built up on the Si3N4 surfaces both in PBS and in bovine serum, controlling the friction and wear characteristics.

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  • 5.
    Persson, Cecilia
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    López, Alejandro
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Fathali, Hoda
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Hoess, Andreas
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Rojas, Ramiro
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Polymer Chemistry.
    Hilborn, Jöns
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Polymer Chemistry.
    Engqvist, Håkan
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    The effect of oligo(trimethylene carbonate) addition on the stiffness of acrylic bone cement2016In: Biomatter, ISSN 2159-2527, E-ISSN 2159-2535, Vol. 6, no 1, article id 1133394Article in journal (Refereed)
    Abstract [en]

    With the increasing elderly population an increase in the number of bony fractures associated toage-related diseases such as osteoporosis also follows. The relatively high stiffness of the acrylicbone cements used in these patients has been suggested to give raise to a suboptimal loaddistribution surrounding the cementin vivo, and hence contribute to clinical complications, such asadditional fractures. The aim of this study was to develop a low-modulus bone cement, based oncurrently used, commercially available poly(methyl methacrylate) (PMMA) cements forvertebroplasty. To this end, acrylate end-functionalized oligo(trimethylene carbonate) (oTMC) wasincorporated into the cements, and the resulting compressive mechanical properties wereevaluated, as well as the cytotoxic and handling properties of selected formulations. Sixteenwt%oTMC was needed in the vertebroplastic cement Osteopal V to achieve an elastic modulus of1063 MPa (SD 74), which gave a corresponding compressive strength of 46.1 MPa (SD 1.9). Cementextracts taken at 1 and 12 hours gave a reduced MG-63 cell viability in most cases, while extractstaken at 24 hours had no significant effect on cell behavior. The modification also gave an increasein setting time, from 14.7 min (SD 1.7) to 18.0 min (SD 0.9), and a decrease in maximumpolymerization temperature, from 41.5C (SD 3.4) to 30.7C (SD 1.4). While further evaluation ofother relevant properties, such as injectability andin vivobiocompatibility, remains to be done, theresults presented herein are promising in terms of approaching clinically applicable bone cementswith a lower stiffness.

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