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  • 1. Bell, Max
    et al.
    Larsson, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
    Venge, Per
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
    Bellomo, Rinaldo
    Mårtensson, Johan
    Assessment of cell-cycle arrest biomarkers to predict early and delayed acute kidney injury2015In: Disease Markers, ISSN 0278-0240, E-ISSN 1875-8630, Vol. 2015, article id 158658Article in journal (Refereed)
    Abstract [en]

    Purpose. To assess urinary tissue inhibitor of metalloproteinases-2 and insulin-like growth factor binding protein 7 ([TIMP-2]·[IGFBP7]), urinary neutrophil gelatinase-associated lipocalin (NGAL), and urinary cystatin-C as acute kidney injury predictors (AKI) exploring the association of nonrenal factors with elevated biomarker levels.

    Methods. We studied 94 patients with urine collected within 48 hours of ICU admission and no AKI at sampling. AKI was defined by the Kidney Disease: Improving Global Outcomes criteria. Predictive performance was assessed by the area under the receiver operating characteristics (ROC) curve. Associations between biomarkers and clinical factors were assessed by multivariate linear regression.

    Results. Overall, 19 patients (20%) developed AKI within 48 hours. [TIMP-2]·[IGFBP7], NGAL, or cystatin-C admission levels did not differ between patients without AKI and patients developing AKI. [TIMP-2]·[IGFBP7], NGAL, and cystatin-C were poor AKI predictors (ROC areas 0.34-0.51). Diabetes was independently associated with higher [TIMP-2]·[IGFBP7] levels (P = 0.02) but AKI was not (P = 0.24). Sepsis was independently associated with higher NGAL (P < 0.001) and cystatin-C (P = 0.003) levels.

    Conclusions. Urinary [TIMP-2]·[IGFBP7], NGAL, and cystatin-C should be used cautiously as AKI predictors in general ICU patients since urine levels of these biomarkers are affected by factors other than AKI and their performance can be poor.

  • 2.
    Gao, Jingfang
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Oncology. Linköping University, Faculty of Health Sciences.
    Zhang, Hong
    Linköping University, Department of Clinical and Experimental Medicine, Dermatology and Venerology. Linköping University, Faculty of Health Sciences.
    Arbman, Gunnar
    Linköping University, Department of Clinical and Experimental Medicine, Surgery. Linköping University, Faculty of Health Sciences.
    Sun, Xiao-Feng
    Linköping University, Department of Clinical and Experimental Medicine, Oncology. Linköping University, Faculty of Health Sciences.
    The different roles of hRAD50 in microsatellite stable and unstable colorectal cancers2008In: Disease Markers, ISSN 0278-0240, E-ISSN 1875-8630, Vol. 24, no 2, p. 127-134Article in journal (Refereed)
    Abstract [en]

    RAD50 protein is essential for DNA double-strand break repair and maintaining genomic integrity. In this study, we investigated the clinicopathological significance of hRAD50 expression and mutation in microsatellite stable (MSS) and unstable (MSI) colorectal cancers (CRCs). hRAD50 expression was examined in primary CRC (n=268), the corresponding distant (n=69) and adjacent normal mucosa (n=138), and lymph node metastasis (n=44) by immunohistochemistry. hRAD50 mutation was analyzed in 87 primary CRCs by PCR-SSCP-DNA sequencing. hRAD50 expression was increased in MSS primary CRCs, but not MSI ones, compared with distant/adjacent normal mucosa (p<0.05). There was no difference in the hRAD50 expression between primary and metastatic CRCs. The increased hRAD50 expression in MSS primary CRCs was related (p<0.05) or tended to be related (p=0.05) to early tumor stage, better differentiation, high inflammatory infiltration, p53 overexpression. Frameshift mutations of (A)_{9} at coding region of hRAD50 were only found in MSI CRCs. Our results suggest that hRAD50 may play different roles in the development of MSS and MSI CRCs: increased hRAD50 expression in MSS CRCs {may be a cellular response against tumor from further progression}, while hRAD50 mutation may be involved in the development of MSI CRCs.

  • 3.
    Ladjevardi, Sam
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Urology.
    Auer, Gert
    Castro, Juan
    Ericsson, Christer
    Zetterberg, Anders
    Häggman, Michael
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Urology.
    Wiksell, Hans
    Jorulf, Håkan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Radiology.
    Prostate biopsy sampling causes hematogenous dissemination of epithelial cellular material2014In: Disease Markers, ISSN 0278-0240, E-ISSN 1875-8630, p. 707529-Article in journal (Refereed)
    Abstract [en]

    The extent of epithelial cellular material (ECM) occurring in venous blood samples after diagnostic core needle biopsy (CNB) was studied in 23 patients with CNB diagnosed prostate cancer without provable metastases and 15 patients without cancer. The data show a significant increase of ECM in the peripheral blood sampled 20 seconds or 30 minutes after the last of 10 CNB procedures compared to the number of ECM detectable in the blood samples taken before the performance of CNB. The data indicate that diagnostic CNB of prostate cancer causes an extensive tissue trauma with a potential risk of cancer cell dissemination.

  • 4.
    Laine, Antti-Pekka
    et al.
    Immunogenetics Laboratory, University of Turku, Finland.
    Holmberg, Hanna
    Linköping University, Department of Molecular and Clinical Medicine, Pediatrics. Linköping University, Faculty of Health Sciences.
    Nilsson, Anita
    Department of Endocrinology and Paediatrics, University Hospital Malmö, University of Lund, Sweden.
    Örtqvist, Eva
    Astrid Lindgren’s Children Hospital, Karolinska Hospital, Stockholm, Sweden.
    Kiviniemi, Minna
    Immunogenetics Laboratory, University of Turku, Finland.
    Vaarala, Outi
    Linköping University, Department of Molecular and Clinical Medicine, Pediatrics. Linköping University, Faculty of Health Sciences. Department of Viral Diseases and Immunology, National Public Health Institute, Helsinki, Finland.
    Åkerblom, Hans K
    Hospital for Children and Adolescents, University of Helsinki, Finland.
    Simell, Olli
    Department of Paediatrics, University of Turku, Turku, Finland.
    Knip, Mikael
    Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland / Department of Pediatrics, Tampere University Hospital, Tampere, Finland.
    Ludvigsson, Johnny
    Linköping University, Department of Molecular and Clinical Medicine, Pediatrics. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center of Paediatrics and Gynaecology and Obstetrics, Department of Paediatrics in Linköping.
    Ivarsson, Sten-A
    Department of Endocrinology and Paediatrics, University Hospital Malmö, University of Lund, Sweden.
    Larsson, Karin
    Department of Endocrinology and Paediatrics, University Hospital Malmö, University of Lund, Sweden.
    Lernmark, Åke
    Department of Endocrinology and Paediatrics, University Hospital Malmö, University of Lund, Sweden.
    Ilonen, Jorma
    Immunogenetics Laboratory, University of Turku, Finland / Department of Clinical Microbiology, University of Kuopio, Finland.
    Two insulin gene single nucleotide polymorphisms associated with type 1 diabetes risk in the Finnish and Swedish populations2007In: Disease Markers, ISSN 0278-0240, E-ISSN 1875-8630, Vol. 23, no 3, p. 139-45Article in journal (Refereed)
    Abstract [en]

    We have developed high-throughput tests for the detection of the insulin gene region SNPs -23HphI and -2221MspI. The potential of these markers to enhance the efficiency of type 1 diabetes risk screening was then evaluated by analyzing them in Finnish and Swedish populations. Blood spots on filter paper were analyzed using PCR followed by sequence-specific hybridization and time-resolved fluorometry reading. Distribution of the genotypes at both positions differed significantly among the affected children compared to the controls. The risk genotypes (CC, AA) were significantly more common in Finland than in Sweden, both among patients and controls. The VNTR genotype homozygous for the protective class III alleles showed a significantly stronger protective effect than the heterozygote (p=0.02). Analyzing both SNPs enabled the detection of VNTR class III subclasses IIIA and IIIB. The observed significance between effects of the protective genotypes was due to the strong protective effect of the IIIA/IIIA genotype. IIIA/IIIA was the only genotype with significant discrepancy between protective effects compared to the other class III genotypes. These observations suggest that heterogeneity between the protective IDDM2 lineages could exist, and analyzing both -23HphI and -2221MspI would thus potentially enhance the sensitivity and specificity of type 1 diabetes risk estimation.

  • 5. Mair, Johannes
    et al.
    Jaffe, Allan
    Apple, Fred
    Lindahl, Bertil
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
    Cardiac Biomarkers2015In: Disease Markers, ISSN 0278-0240, E-ISSN 1875-8630, p. 1-3Article in journal (Other academic)
  • 6.
    Sundström, Johan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Internal Medicine.
    Myocardial biomarkers for prediction of cardiovascular disease2009In: Disease Markers, ISSN 0278-0240, E-ISSN 1875-8630, Vol. 26, no 5-6, p. 235-246Article, review/survey (Refereed)
    Abstract [en]

    The identification of those persons in the population who have the highest risk of future cardiovascular events is important for targeting intensive preventive efforts. This can be reliably done using a handful of long since established risk factors. The unmet need for new molecular biomarkers for prediction of cardiovascular events in the general population is therefore low. In order for a new biomarker to be used clinically for risk prediction, a statistically significant association of levels of the biomarker to adverse outcome is not enough, but the biomarker should also be demonstrated to add discriminative capacity beyond established risk factors. In contrast to the limited value of new biomarkers for risk prediction, their usefulness for unraveling the pathophysiology of cardiovascular disease is large. The myocardium is the source of a vast number of interesting biomarkers, of which a few may be useful for risk prediction in the general population. Two of these, troponin-I and the N-terminal fragment of brain natriuretic peptide, have passed tests of added discriminatory value. Numerous other biomarkers produced by cardiomyocytes or non-cardiomyocytes in the myocardium are promising, and if they are not proven useful for risk prediction, they will unquestionably enhance our understanding of cardiovascular disease.

  • 7.
    Wang, Chao-Jie
    et al.
    Sichuan University.
    Zhou, Zong-Guang
    Sichuan University.
    Wang, Ling
    Sichuan University.
    Yang, Lie
    Sichuan University.
    Zhou, Bin
    Sichuan University.
    Gu, Jun
    Sichuan University.
    Chen, Hong-Ying
    Sichuan University.
    Sun, Xiao-Feng
    Linköping University, Department of Clinical and Experimental Medicine, Oncology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Oncology UHL.
    Clinicopathological significance of microRNA-31, -143 and -145 expression in colorectal cancer2009In: Disease Markers, ISSN 0278-0240, E-ISSN 1875-8630, Vol. 26, no 1, p. 27-34Article in journal (Refereed)
    Abstract [en]

    We are just beginning to understand how microRNAs (miRNAs) are involved in tumor-related processes in humans. Applying real-time RT-PCR, we investigated the miR-31, miR-143 and miR-145 expression in 98 primary CRC specimens, along with the corresponding normal mucosa specimens, and analyze the relationship of their expression with clinicopathological features. Our results showed the miR-31 expression was up-regulated in CRC compared to normal mucosa (p = 0.001). Furthermore, miR-31 expression was positively related to advanced TNM stage (p = 0.026) and deeper invasion of tumors (p = 0.024). MiR-145 was down-regulated in both colon (p = 0.001) and rectal (p = 0.012) cancer. MiR-143 was only down-regulated in colon cancer (p = 0.023) but not in rectal cancer (p = 0.351). There was no relationship of miR-143 and miR-145 expression with other clinicopathological features (p > 0.05), except that the miR-145 expression was related to cancer site (p = 0.03). In conclusion, the miR-31 overexpression may be involved in the development and progression of CRC. The miR-143 and miR-145 may play a certain role in the development of colon and/or rectal cancers but not in progression of the disease.

  • 8.
    Wu, Ping-Hsun
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Endocrinology and mineral metabolism. Kaohsiung Med Univ, Coll Med, Grad Inst Clin Med, Kaohsiung, Taiwan;Kaohsiung Med Univ, Coll Med, Fac Med, Kaohsiung, Taiwan;Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Nephrol, Kaohsiung, Taiwan.
    Yi-Ting, Lin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology. Kaohsiung Med Univ, Coll Med, Grad Inst Clin Med, Kaohsiung, Taiwan;Kaohsiung Med Univ, Coll Med, Fac Med, Kaohsiung, Taiwan;Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Family Med, Kaohsiung, Taiwan.
    Wu, Pei-Yu
    Kaohsiung Med Univ, Coll Med, Grad Inst Clin Med, Kaohsiung, Taiwan;Kaohsiung Med Univ, Coll Med, Fac Med, Kaohsiung, Taiwan;Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Nephrol, Kaohsiung, Taiwan;Kaohsiung Med Univ, Kaohsiung Municipal Hsiao Kang Hosp, Dept Internal Med, Kaohsiung, Taiwan.
    Huang, Jiun-Chi
    Kaohsiung Med Univ, Coll Med, Grad Inst Clin Med, Kaohsiung, Taiwan;Kaohsiung Med Univ, Coll Med, Fac Med, Kaohsiung, Taiwan;Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Nephrol, Kaohsiung, Taiwan;Kaohsiung Med Univ, Kaohsiung Municipal Hsiao Kang Hosp, Dept Internal Med, Kaohsiung, Taiwan.
    Chen, Szu-Chia
    Kaohsiung Med Univ, Coll Med, Grad Inst Clin Med, Kaohsiung, Taiwan;Kaohsiung Med Univ, Coll Med, Fac Med, Kaohsiung, Taiwan;Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Nephrol, Kaohsiung, Taiwan;Kaohsiung Med Univ, Kaohsiung Municipal Hsiao Kang Hosp, Dept Internal Med, Kaohsiung, Taiwan.
    Chang, Jer-Ming
    Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Nephrol, Kaohsiung, Taiwan;Kaohsiung Med Univ, Kaohsiung Municipal Hsiao Kang Hosp, Dept Internal Med, Kaohsiung, Taiwan;Kaohsiung Med Univ, Coll Med, Fac Renal Care, Kaohsiung, Taiwan.
    Chen, Hung-Chun
    Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Nephrol, Kaohsiung, Taiwan;Kaohsiung Med Univ, Kaohsiung Municipal Hsiao Kang Hosp, Dept Internal Med, Kaohsiung, Taiwan;Kaohsiung Med Univ, Coll Med, Fac Renal Care, Kaohsiung, Taiwan.
    A Low Ankle-Brachial Index and High Brachial-Ankle Pulse Wave Velocity Are Associated with Poor Cognitive Function in Patients Undergoing Hemodialysis2019In: Disease Markers, ISSN 0278-0240, E-ISSN 1875-8630, Vol. 2019, article id 9421352Article in journal (Refereed)
    Abstract [en]

    Patients with end-stage renal disease (ESRD) have an increased risk of both impaired cognitive function and peripheral artery disease (PAD) than the general population. The association between PAD and dementia is recognized, but there are limited studies in patients with ESRD. The aim of this study was to evaluate the relationship between ankle-brachial index (ABI) and brachial-ankle pulse wave velocity (baPWV) and cognitive impairment in patients receiving hemodialysis (HD). We enrolled 136 prevalent HD patients (mean age 59.3 +/- 10.5 years, 55.9% male). Cognitive performance was measured using the Montreal Cognitive Assessment (MoCA) and Cognitive Abilities Screening Instrument (CASI) by trained psychiatrists. Associations between the cognitive function and ABI and baPWV were assessed using multiple linear regression analysis. Compared with HD patients with ABI >= 0.9, patients with ABI<0.9 had lower MoCA score (p=0.027) and lower CASI score but did not achieve significant level (p=0.056). In the multivariate stepwise linear regression analysis, ABI (per 0.1) was independently positively associated with the MoCA score (beta coefficient=0.62, p=0.011) and the CASI score (beta coefficient=1.43, p=0.026). There is a negative association between baPWV (per 100cm/s) and CASI (beta coefficient=-0.70, p=0.009). In conclusion, a low ABI or high baPWV was associated with a lower cognitive function in HD patients.

  • 9.
    Zhu, Zhen-Long
    et al.
    Hebei Medical University, Shijiazhuang, China.
    Yan, Bao-Yong
    Hebei Medical University, Shijiazhuang, China.
    Zhang, Yu
    Hebei Medical University, Shijiazhuang, China.
    Yang, Yan-Hong
    Hebei Medical University, Shijiazhuang, China.
    Wang, Ming-Wei
    Hebei Medical University, Shijiazhuang, China.
    Zentgraf, Hanswalter
    Heidelberg University, Germany.
    Zhang, Xiang-Hong
    Hebei Medical University, Shijiazhuang, China.
    Sun, Xiao-Feng
    Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Oncology.
    Overexpression of FXYD-3 is involved in the tumorigenesis and development of esophageal squamous cell carcinoma2013In: Disease Markers, ISSN 0278-0240, E-ISSN 1875-8630, Vol. 35, no 3, p. 195-202Article in journal (Refereed)
    Abstract [en]

    Objective: To investigate the association of FXYD-3 expression with clinicopathological variables and PINCH in patients with ESCC.

    Patients and methods: Expression of FXYD-3 protein was immunohistochemically examined in normal esophageal mucous (n = 20) and ESCC (n = 64).  

    Results: Expression of FXYD-3 in the cytoplasm markedly increased from normal esophageal epithelial cells to primary ESCC ( p = 0.001). The expression of FXYD-3 was correlated with TNM stages and depth of tumour invasion. Furthermore, the cases with lymph node metastasis tended to show a higher frequency of positive expression than those without metastasis ( p = 0.086), and FXYD-3 expression tended to be positively related to the expression of PINCH (p = 0.063). Moreover, the cases positive for both proteins had the highest frequency of lymph node metastasis (p = 0.001). However, FXYD-3 expression was not correlated with patient,s gender (p = 0.847), age (p = 0.876), tumour location (p = 0.279), size (p = 0.771) , grade of differentiation (p = 0.279), and survival (p = 0.113).

    Conclusion: overexpression of FXYD-3 in the cytoplasm may play an important role in the tumourigenesis and development in the human ESCC, particularly in combination with PINCH expression.

  • 10.
    Zhu, Zhen-Long
    et al.
    Hebei Medical University, Peoples R China.
    Yan, Bao-Yong
    Hebei Medical University, Peoples R China .
    Zhang, Yu
    Hebei Medical University, Peoples R China .
    Yang, Yan-Hong
    Hebei Medical University, Peoples R China .
    Wang, Zheng-Min
    Hebei Medical University, Peoples R China .
    Zhang, Hong-Zhen
    Hebei Medical University, Peoples R China .
    Wang, Ming-Wei
    Hebei Medical University, Peoples R China .
    Zhang, Xiang-Hong
    Hebei Medical University, Peoples R China .
    Sun, Xiao-Feng
    Linköping University, Department of Clinical and Experimental Medicine, Oncology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Surgery, Orthopaedics and Cancer Treatment, Department of Oncology UHL.
    PINCH expression and its clinicopathological significance in gastric adenocarcinoma2012In: Disease Markers, ISSN 0278-0240, E-ISSN 1875-8630, Vol. 33, no 4, p. 171-178Article in journal (Refereed)
    Abstract [en]

    Objective: Particularly interesting new cysteine-histidine rich protein (PINCH) is an important component of the local adhesion complexes and upregulated in several types of malignancies, and involved in the incidence and development of tumours. PINCH expression is also independently correlated with poorer survival in patients with colorectal cancer. However, there is no study of PINCH in gastric cancer, therefore, the aim of this project was to investigate PINCH expression and its clinicopathological significance in gastric adenocarcinoma. less thanbrgreater than less thanbrgreater thanPatients and methods: PINCH expression was immunohistochemically examined in normal gastric mucous (n = 30) and gastric adenocarcinoma (n = 73), from gastric cancer patients. less thanbrgreater than less thanbrgreater thanResults: PINCH expression in the associated-stroma of gastric cancers was heterogeneous, and its positive rate (75%) was higher than that of normal gastric mucosa (43%, X-2 = 9.711, p = 0.002). The stronger staining was observed at the invasive edge of tumour when compared to the inner area of tumour. The rate of positive PINCH (88%) in the cases with lymph node metastasis was higher than that (52%) in the cases without metastasis (X-2 = 11.151, p = 0.001). PINCH expression was not correlated with patients gender, age, tumour size, differentiation and invasion depth (p andgt; 0.05). less thanbrgreater than less thanbrgreater thanConclusion: PINCH protein might play an important role in the tumourigenesis and metastasis of gastric adenocarcinoma.

  • 11.
    Zhu, Zhenlong
    et al.
    Department of Pathology, The First Hospital of Hebei Medical University, China.
    Yang, Yanhong
    Department of Pathology, The First Hospital of Hebei Medical University, China.
    Zhang, Yu
    Clinical College, Hebei Medical University, China.
    Wang, Zhengmin
    Department of Pathology, The First Hospital of Hebei Medical University, China.
    Cui, Dongsheng
    Central Laboratory, The First Hospital of Hebei Medical University, China.
    Zhang, Jinting
    Central Laboratory, The First Hospital of Hebei Medical University, China.
    Wang, Mingwei
    Central Laboratory, The First Hospital of Hebei Medical University, China.
    Sun, Xiao-Feng
    Linköping University, Department of Clinical and Experimental Medicine, Oncology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Oncology UHL.
    PINCH expression and its significance in esophageal squamous cell carcinoma2008In: Disease Markers, ISSN 0278-0240, E-ISSN 1875-8630, Vol. 25, no 2, p. 75-80Article in journal (Refereed)
    Abstract [en]

    Particularly interesting new cysteine-histidine rich protein (PINCH), as a newly discovered protein of LIM family members, may play a role in signal transduction of integrin and growth factor, and involved in the incidence and development of tumors. PINCH protein is overexpressed in tumor-associated stroma of several types of tumors. However, there is no study of the PINCH in esophageal cancer, therefore we investigated PINCH expression in esophageal squamous cell carcinomas and its clinicopathogical significance in the patients. PINCH expression was immunohistochemically examined in 20 normal esophageal samples and 64 esophageal squamous cell carcinomas. The results showed that PINCH expression in the stroma of cancers was heterogeneous, and its positive rate (56%) was higher than that of normal esophageal mucosa (5%, p<0.0001). The stronger staining was observed at the invasive edge of tumor when compared to the inner area of tumor. The rate of positive PINCH (90%) in the cases with lymph node metastasis was higher than that (41%) in the cases without metastasis (p<0.0001). PINCH expression was not correlated with patients’ gender, age, tumor location, size and differentiation (p>0.05). The results suggest that PINCH protein may be a marker of tumor associated-stroma involving tumor development, and predicting the ability of invasion and metastasis of esophageal squamous cell carcinoma.

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