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  • 1. Buehler, S.
    et al.
    Schumann, S.
    Lichtwarck-Aschoff, Michael
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Anestesiologi och intensivvård.
    Lozano, S.
    Guttmann, J.
    The shape of intratidal resistance-volume and compliance-volume curves in mechanical ventilation - an animal study2013Ingår i: Biomedizinische Technik (Berlin. Zeitschrift), ISSN 1862-278X, E-ISSN 0013-5585, Vol. 58Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    In respiratory system mechanics, the shape of the intratidal pulmonary compliance-volume curve can be used to detect atelectasis or overdistension in the mechanically ventilated lung and thus to optimise the ventilator setting in terms of positive end-expiratory pressure (PEEP) and tidal volume (V-T). To this end, a set of shape-categories had been suggested. Furthermore, a characteristic behaviour of the intratidal resistance is expected as a consequence of alveolar recruitment and overdistension of the airways. We inspect the intratidal compliance and resistance profiles in mechanically ventilated pigs and suggest a classification into slope-categories for the resistance profile which could be used in combination with the compliance shape-categories to optimize PEEP and V-T.

  • 2.
    Chow, Winnie W. Y.
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi.
    Herwik, Stanislav
    Kisban, Sebastian
    Ruther, Patrick
    Neves, Herc
    Oscarsson, Sven
    Gothelid, Emmanuelle
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Fysiska sektionen, Institutionen för fysik och astronomi.
    Influence of bio-coatings on the recording performance of neural electrodes2014Ingår i: Biomedizinische Technik (Berlin. Zeitschrift), ISSN 1862-278X, E-ISSN 0013-5585, Vol. 59, nr 4, s. 315-322Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Neural probes are complex devices consisting of metallic (often Pt based) electrodes, spread over an insolating/dielectric backbone. Their functionality is often limited in time because of the formation of scaring tissues around the implantation tracks. Functionalization of the probes surface can be used to limit the glial scar reaction. This is however challenging, as this treatment has to be equally efficient on all probe surfaces (metallic as well as dielectric) and should not influence the electrodes performances. This paper presents a novel technique to functionalize recording neural probes with hyaluronic acid (HyA), a major component of the extracellular matrix (ECM). HyA and the probe surface are both modified to make the reaction feasible: HyA is chemically functionalized with SS-pyridine groups while the probe surfaces are silanized. The thiol groups thus introduced on the probe surface can then react with the HyA SS-pyridine group, resulting in a covalent bonding of the latter on the former. The electrodes are protected by introducing a pretreatment step, namely an additional hyaluronic acid layer on the platinum electrode, prior to the silanization process, which was found to be effective in reducing electrode impedance under optimized conditions.

  • 3. Chow, Winnie W. Y.
    et al.
    Herwik, Stanislav
    Kisban, Sebastian
    Ruther, Patrick
    Neves, Herc
    Oscarsson, Sven
    Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för organisk kemi.
    Gothelid, Emmanuelle
    Influence of bio-coatings on the recording performance of neural electrodes2014Ingår i: Biomedizinische Technik (Berlin. Zeitschrift), ISSN 1862-278X, E-ISSN 0013-5585, Vol. 59, nr 4, s. 315-322Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Neural probes are complex devices consisting of metallic (often Pt based) electrodes, spread over an insolating/dielectric backbone. Their functionality is often limited in time because of the formation of scaring tissues around the implantation tracks. Functionalization of the probes surface can be used to limit the glial scar reaction. This is however challenging, as this treatment has to be equally efficient on all probe surfaces (metallic as well as dielectric) and should not influence the electrodes performances. This paper presents a novel technique to functionalize recording neural probes with hyaluronic acid (HyA), a major component of the extracellular matrix (ECM). HyA and the probe surface are both modified to make the reaction feasible: HyA is chemically functionalized with SS-pyridine groups while the probe surfaces are silanized. The thiol groups thus introduced on the probe surface can then react with the HyA SS-pyridine group, resulting in a covalent bonding of the latter on the former. The electrodes are protected by introducing a pretreatment step, namely an additional hyaluronic acid layer on the platinum electrode, prior to the silanization process, which was found to be effective in reducing electrode impedance under optimized conditions.

  • 4.
    Coyle, D.
    et al.
    University of Ulster.
    Prasad, G.
    University of Ulster.
    McGinnity, T.M.
    University of Ulster.
    Herman, Pawel Andrzej
    University of Ulster.
    Estimating the Predictability of EEG Recorded Over the Motor Cortex Using Information Theoretic Functionals2004Ingår i: Biomedizinische Technik (Berlin. Zeitschrift), ISSN 1862-278X, E-ISSN 0013-5585, Vol. 49, nr 1, s. 43-44Artikel i tidskrift (Refereegranskat)
  • 5. Dombovari, Balazs
    et al.
    Fiath, Richard
    Kerekes, Balint Peter
    Toth, Emilia
    Wittner, Lucia
    Horvath, Domonkos
    Seidl, Karsten
    Herwik, Stanislav
    Torfs, Tom
    Paul, Oliver
    Ruther, Patrick
    Neves, Hercules Pereira
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Fasta tillståndets elektronik.
    Ulbert, Istvan
    In vivo validation of the electronic depth control probes2014Ingår i: Biomedizinische Technik (Berlin. Zeitschrift), ISSN 1862-278X, E-ISSN 0013-5585, Vol. 59, nr 4, s. 283-289Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    In this article, we evaluated the electrophysiological performance of a novel, high-complexity silicon probe array. This brain-implantable probe implements a dynamically reconfigurable voltage-recording device, coordinating large numbers of electronically switchable recording sites, referred to as electronic depth control (EDC). Our results show the potential of the EDC devices to record good-quality local field potentials, and single- and multiple-unit activities in cortical regions during pharmacologically induced cortical slow wave activity in an animal model.

  • 6.
    Killmann, M
    et al.
    University of Medical Centre Freiburg, Germany .
    Sommerlade, L
    University of Freiburg, Germany .
    Mader, W
    University of Freiburg, Germany .
    Timmer, Jens
    Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för klinisk och experimentell medicin, Cellbiologi.
    Schelter, B
    University of Freiburg, Germany .
    Inference of time-dependent causal influences in Networks2012Ingår i: Biomedizinische Technik (Berlin. Zeitschrift), ISSN 1862-278X, E-ISSN 0013-5585, Vol. 57Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    We address the challenge of detecting time-variant interactions in multivariate systems. Inferring Granger-causal interactions between processes promises to gain deeper insights into mechanisms underlying network phenomena, e. g., in the neurosciences. Renormalized partial directed coherence (rPDC) has been introduced as a means to investigate Granger causality in such multivariate systems. When using rPDC a major challenge is the reliable estimation of parameters in vector autoregressive processes. For time-varying connections a time-resolved estimation of the coefficients is mandatory. We show that the State Space Model in combination with the Kalman filter is a powerful tool for estimating time-variate AR process parameters.

  • 7.
    Litscher, G
    et al.
    Graz Univ, Klin Anasthesiol & Intensivmed, LKH, A-8036 Graz, Austria Linkoping Univ, S-58183 Linkoping, Sweden.
    Wang, L
    Graz Univ, Klin Anasthesiol & Intensivmed, LKH, A-8036 Graz, Austria Linkoping Univ, S-58183 Linkoping, Sweden.
    Nilsson, G
    Laser Doppler imaging and cryoglobulinaemia2001Ingår i: Biomedizinische Technik (Berlin. Zeitschrift), ISSN 1862-278X, E-ISSN 0013-5585, Vol. 46, nr 6, s. 154-157Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Continuous microcirculation monitoring of the right foot was carried out for the first time in a 62-year-old patient with cryoglobulinaemia prior to, during and after manual needle insertion at Jic Xi(St.41) acupuncture point using a new method of laser Doppler perfusion imaging (PIMII, Lisca AB, Linkoping, Sweden). In addition to visual inspection, changes in mean perfusion were also used as evaluation parameters. Our results suggest that the new biomedical technique of laser Doppler imaging is a useful method for monitoring the effects of acupuncture on the peripheral microcirculation.

  • 8. Schmidt, Thomas
    et al.
    Balzani, Daniel
    Schriefl, Andreas J.
    Holzapfel, Gerhard A.
    KTH, Skolan för teknikvetenskap (SCI), Hållfasthetslära (Inst.).
    Material Modeling Of The Damage Behavior Of Arterial Tissues2013Ingår i: Biomedizinische Technik (Berlin. Zeitschrift), ISSN 1862-278X, E-ISSN 0013-5585, Vol. 58, nr (Suppl. 1)Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    In this contribution we present a damage model for collagenous soft tissues such as arterial walls, which takes into account the statistical distributions of microscopic parameters. This approach extends the constitutive framework proposed in [1] by specific damage functions arising from microscopical considerations. In detail, statistical distributions of proteoglycan (PG) orientations, fibril length parameters and ultimate proteoglycan stretch can be considered, cf. [2]. The influence of each distributed quantity on the damage behavior is investigated by adjusting the model to uniaxial experimental data of a human carotid artery. Furthermore, the proposed model is implemented into a finite element framework and used within a numerical example in order to show its applicability to inhomogeneous boundary-value problems.

  • 9. Schriefl, Andreas J.
    et al.
    Schmidt, Thomas
    Balzani, Daniel
    Holzapfel, Gerhard A.
    KTH, Skolan för teknikvetenskap (SCI), Hållfasthetslära (Inst.).
    Determination Of Mechanical And Microstructural Tissue Quantities For Modeling Damage In Arterial Tissues2013Ingår i: Biomedizinische Technik (Berlin. Zeitschrift), ISSN 1862-278X, E-ISSN 0013-5585, Vol. 58, nr (Suppl. 1)Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The overstretching of arterial walls as it occurs, e.g., during balloon angioplasty, results in a stress-softening of the collagenous wall which is believed to arise from microscopic tissue damage. To model such damage we use a macroscopic, fiber-reinforced constitutive framework including a characterization of the individual tissue components. We employed traditional and novel experimental investigations to determine and quantify the required mechanical and microstructural tissue parameters for the constitutive model. Herein we present some of our experimental approaches and the resulting preliminary findings.

  • 10. Schumann, S.
    et al.
    Vimlati, Laszlo
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Anestesiologi och intensivvård.
    Lichtwarck-Aschoff, Michael
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Anestesiologi och intensivvård.
    Guttmann, J.
    Dynamic Hysteresis Behaviour of Respiratory System Mechanics2013Ingår i: Biomedizinische Technik (Berlin. Zeitschrift), ISSN 1862-278X, E-ISSN 0013-5585, Vol. 58Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The static pressure-volume (PV) curve of the respiratory system is characterized by hysteresis behaviour. Determination of separate inspiratory and expiratory compliance is required to analyse this phenomenon during the dynamic situation of mechanical ventilation. In five piglets expiratory flow was linearized (flow-controlled expiration, FLEX) to allow for compliance estimation separately for inspiration and expiration. Expiratory compliance was higher than inspiratory compliance along the entire intratidal course, converging at higher volumes. At higher PEEP levels expiratory and inspiratory compliance tended to run more in parallel. We conclude that the analysis of the separate inspiratory and expiratory compliance profiles allows for indicating unfavourable mechanical ventilation settings.

  • 11. Sommer, G.
    et al.
    Schwarz, M.
    Kutschera, M.
    Kresnik, R.
    Regitnig, P.
    Schriefl, A. J.
    Wolinski, H.
    Kohlwein, S. D.
    Holzapfel, Gerhard A.
    KTH, Skolan för teknikvetenskap (SCI), Hållfasthetslära (Inst.).
    Biomechanical Properties Of The Human Ventricular Myocardium2013Ingår i: Biomedizinische Technik (Berlin. Zeitschrift), ISSN 1862-278X, E-ISSN 0013-5585, Vol. 58, nr (Suppl. 1)Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    In the multidisciplinary field of heart research it is of utmost importance, for the description of phenomena such as mechano-electric feedback or heart wall thickening, to accurately identify the biomechanical properties of the myocardium. Hence, this study aims at determining biaxial tensile and triaxial shear properties of the passive human myocardium. This novel combination of biaxial and shear testing, together with the investigation of the myocardial microstructure, yields new innovative and essential information of the material properties to fulfil the short term goals of constructing realistic myocardial models. Through such modeling efforts, capable to capture the biomechanical behaviour of the heart, it is possible to improve some methods of medical treatment, and hence the quality of life for people suffering from heart diseases - at least as a long-term goal.

  • 12. Stieglitz, Thomas
    et al.
    Neves, Hercules
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Fasta tillståndets elektronik.
    Ruther, Patrick
    Neural probes - microsystems to interface with the brain2014Ingår i: Biomedizinische Technik (Berlin. Zeitschrift), ISSN 1862-278X, E-ISSN 0013-5585, Vol. 59, nr 4, s. 269-271Artikel i tidskrift (Refereegranskat)
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