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Nanoparticle transport and deposition in human lung
Luleå University of Technology, Department of Engineering Sciences and Mathematics, Fluid and Experimental Mechanics.
2009 (English)In: Interdisciplinary transport phenomena: fluid, thermal, biological, materials, and space sciences ; [result of a conference entitled "Interdisciplinary Transport Phenomena V: Fluid, Thermal, Biological, Materials, and Space Sciences", held on October 14 - 19, 2007 in Bansko, Bulgaria], Boston, Mass.: Blackwell Munksgaard, 2009, Paper No: ITP-07 p.Chapter in book (Refereed)
Abstract [en]

Transport and deposition properties of micro- and nanoparticles in human lung are of great importance in health risk assessments on potentially toxic matter, such as carbon nanotubes. The risks largely depend on the extent of exposure; thus if effects upon inhalation are considered, it is crucial to clarify the differences in transport mechanics between nano- and microparticles. In this work, we examined deposition properties of spherical particles (r = 1950 kg/m3), 15 nm - 50 mm in diameter, in a multiply bifurcated asymmetric 3D model, extending from trachea to the segmental bronchi. Steady, laminar flow was studied for inhalation flow rates of 0.1 and 0.5 l/s, and Computational Fluid Dynamics was used for analysis. Most 50 mm particles were captured near the first bifurcation, whereas particles 1-10 mm were less efficiently, but more uniformly, deposited. The nanoparticles essentially followed the streamlines, unaffected of the deposition mechanisms modeled. Deposition efficiency for microparticles was in the same order of magnitude as reported in previously published work when regarded on generation level, except in trachea. Our model added new information by predicting distribution of deposited particles in every bifurcation unit (two daughter branches and preceding transition zone), and site of deposition was more or less affected by geometric asymmetry. In conclusion, our results indicate that nanoparticle deposition is negligible in the larger airways, thus transport to the distal airways can be assumed extensive. Further, distribution of deposited particles was influenced by the airway asymmetry. However, more work and validating experiments are required before the model can be used as a tool in particle risk assessments.

Place, publisher, year, edition, pages
Boston, Mass.: Blackwell Munksgaard, 2009. Paper No: ITP-07 p.
Research subject
Fluid Mechanics
URN: urn:nbn:se:ltu:diva-20000Local ID: 0f653190-bad6-11dc-96bd-000ea68e967bISBN: 978-1-573-31712-2OAI: diva2:993044

Godkänd; 2007; 20080104 (sofhog)

Available from: 2016-09-29 Created: 2016-09-29 Last updated: 2016-10-19Bibliographically approved

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Högberg, SofieÅkerstedt, HansLundström, Staffan
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