Heme transfer reactions: an important prerequisite for synthetic oxygen carriers
1998 (English)In: Turkish journal of chemistry, ISSN 1300-0527, E-ISSN 1303-6130, Vol. 22, no 2, 103-108 p.Article in journal (Refereed) Published
Electronic changes of iron- and metal free porphyrins are reviewed in light of their importance to modify the ferri/ferro reduction potential and energy dissipation between ligated carbon monoxide and the porphyrin chelate. Substitutions at positions 2 and 4 are effective ways to exercise this influence. Other measures include exposure to water and modifications of axial ligation, including the \lq three-ligand' case. These measures will also influence the stability of recombined hemin-protein entities, as apparent from the kinetics of heme-transfer from a modified donor protein to apomyoglobin, but the stability appears to be related to the bulkiness of 2,4-substitutional groups rather than to electron availability. It is suggested that the altered stability is a secondary effect from enhanced exposure to water in the crevice.
Place, publisher, year, edition, pages
1998. Vol. 22, no 2, 103-108 p.
Research subject Fysik
IdentifiersURN: urn:nbn:se:ltu:diva-11115Local ID: a054ecb0-3950-11dd-8721-000ea68e967bOAI: oai:DiVA.org:ltu-11115DiVA: diva2:984064
Upprättat; 1998; 20080613 (ysko)2016-09-292016-09-29