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Polymer-based microfluidic devices for pharmacy, biology and tissue engineering
Luleå University of Technology, Department of Computer Science, Electrical and Space Engineering, Signals and Systems.
Luleå University of Technology, Department of Computer Science, Electrical and Space Engineering, Signals and Systems.
Luleå University of Technology, Department of Computer Science, Electrical and Space Engineering, Signals and Systems.
2012 (English)In: Polymers, ISSN 2073-4360, E-ISSN 2073-4360, Vol. 4, no 3, 1349-1398 p.Article in journal (Refereed) Published
Abstract [en]

This paper reviews microfluidic technologies with emphasis on applications in the fields of pharmacy, biology, and tissue engineering. Design and fabrication of microfluidic systems are discussed with respect to specific biological concerns, such as biocompatibility and cell viability. Recent applications and developments on genetic analysis, cell culture, cell manipulation, biosensors, pathogen detection systems, diagnostic devices, high-throughput screening and biomaterial synthesis for tissue engineering are presented. The pros and cons of materials like polydimethylsiloxane (PDMS), polymethylmethacrylate (PMMA), polystyrene (PS), polycarbonate (PC), cyclic olefin copolymer (COC), glass, and silicon are discussed in terms of biocompatibility and fabrication aspects. Microfluidic devices are widely used in life sciences. Here, commercialization and research trends of microfluidics as new, easy to use, and cost-effective measurement tools at the cell/tissue level are critically reviewed.

Place, publisher, year, edition, pages
2012. Vol. 4, no 3, 1349-1398 p.
National Category
Other Medical Engineering
Research subject
Medical Engineering for Healthcare
Identifiers
URN: urn:nbn:se:ltu:diva-5783DOI: 10.3390/polym4031349Local ID: 3f73a5e4-7ed1-4dde-9651-b7610dcc78bcOAI: oai:DiVA.org:ltu-5783DiVA: diva2:978658
Note
Validerad; 2012; 20120703 (ahmahm)Available from: 2016-09-29 Created: 2016-09-29 Last updated: 2017-11-24Bibliographically approved

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