Change search
ReferencesLink to record
Permanent link

Direct link
Altered Brain Microstate Dynamics in Adolescents with Narcolepsy
Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Linköping University, Faculty of Medicine and Health Sciences.
University of Gothenburg, Sweden.
Linköping University, Center for Medical Image Science and Visualization (CMIV). Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Behavioural Sciences and Learning, Disability Research. Linköping University, Faculty of Arts and Sciences.
Show others and affiliations
2016 (English)In: Frontiers in Human Neuroscience, ISSN 1662-5161, E-ISSN 1662-5161, Vol. 10, no 369Article in journal (Refereed) Published
Abstract [en]

Narcolepsy is a chronic sleep disorder caused by a loss of hypocretin-1 producing neurons in the hypothalamus. Previous neuroimaging studies have investigated brain function in narcolepsy during rest using positron emission tomography (PET) and single photon emission computed tomography (SPECT). In addition to hypothalamic and thalamic dysfunction they showed aberrant prefrontal perfusion and glucose metabolism in narcolepsy. Given these findings in brain structure and metabolism in narcolepsy, we anticipated that changes in functional magnetic resonance imaging (fMRI) resting state network (RSN) dynamics might also be apparent in patients with narcolepsy. The objective of this study was to investigate and describe brain microstate activity in adolescents with narcolepsy and correlate these to RSNs using simultaneous fMRI and electroencephalography (EEG). Sixteen adolescents (ages 13-20) with a confirmed diagnosis of narcolepsy were recruited and compared to age-matched healthy controls. Simultaneous EEG and fMRI data were collected during 10 min of wakeful rest. EEG data were analyzed for microstates, which are discrete epochs of stable global brain states obtained from topographical EEG analysis. Functional fMRI data were analyzed for RSNs. Data showed that narcolepsy patients were less likely than controls to spend time in a microstate which we found to be related to the default mode network and may suggest a disruption of this network that is disease specific. We concluded that adolescents with narcolepsy have altered resting state brain dynamics.

Place, publisher, year, edition, pages
FRONTIERS MEDIA SA , 2016. Vol. 10, no 369
Keyword [en]
narcolepsy; default mode network; functional magnetic resonance imaging (fMRI); electroencephalography (EEG); microstates; resting state networks; orexin; sleep
National Category
URN: urn:nbn:se:liu:diva-131167DOI: 10.3389/fnhum.2016.00369ISI: 000380989900001PubMedID: 27536225OAI: diva2:972168

Funding Agencies|Research Council of South East Sweden (FORSS); Knut and Alice Wallenberg foundation (KAW); strategic research area of systems neurobiology at Linkoping University; Country council of Ostergotland Sweden

Available from: 2016-09-20 Created: 2016-09-12 Last updated: 2016-10-12

Open Access in DiVA

fulltext(1960 kB)4 downloads
File information
File name FULLTEXT01.pdfFile size 1960 kBChecksum SHA-512
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Morales Drissi, NatashaWitt, SuzanneWretman, AnnaUlander, MartinLandtblom, Anne-MarieEngström, Maria
By organisation
Division of Radiological SciencesFaculty of Medicine and Health SciencesCenter for Medical Image Science and Visualization (CMIV)Disability ResearchFaculty of Arts and SciencesDivision of Neuro and Inflammation ScienceDepartment of Clinical NeurophysiologyDepartment of Neurology
In the same journal
Frontiers in Human Neuroscience

Search outside of DiVA

GoogleGoogle Scholar
Total: 4 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 17 hits
ReferencesLink to record
Permanent link

Direct link