Change search
ReferencesLink to record
Permanent link

Direct link
Molecular Features of Subtype-Specific Progression from Ductal Carcinoma In Situ to Invasive Breast Cancer
McGill Univ, Dept Biochem, Montreal, PQ H3G 1Y6, Canada.;McGill Univ, McGill Ctr Bioinformat, Montreal, PQ H3G 1Y6, Canada.;McGill Univ, Rosalind & Morris Goodman Canc Res Ctr, Montreal, PQ H3A 1A3, Canada..
Norwegian Radium Hosp, Oslo Univ Hosp, Inst Canc Res, N-0424 Oslo, Norway.;Norwegian Radium Hosp, Oslo Univ Hosp, Dept Canc Genet, N-0424 Oslo, Norway.;Univ Oslo, Inst Clin Med, KG Jebsen Ctr Breast Canc Res, N-0318 Oslo, Norway..
Norwegian Radium Hosp, Oslo Univ Hosp, Inst Canc Res, N-0424 Oslo, Norway.;Norwegian Radium Hosp, Oslo Univ Hosp, Dept Canc Genet, N-0424 Oslo, Norway..
Univ Oslo, Oslo Ctr Biostat & Epidemiol, N-0317 Oslo, Norway.;Univ Oslo, Dept Biostat, N-0317 Oslo, Norway. St Olavs Univ Hosp, Dept Oncol, N-7006 Trondheim, Norway..
Show others and affiliations
2016 (English)In: Cell reports, ISSN 2211-1247, E-ISSN 2211-1247, Vol. 16, no 4, 1166-1179 p.Article in journal (Refereed) Published
Abstract [en]

Breast cancer consists of at least five main molecular "intrinsic'' subtypes that are reflected in both pre-invasive and invasive disease. Although previous studies have suggested that many of the molecular features of invasive breast cancer are established early, it is unclear what mechanisms drive progression and whether the mechanisms of progression are dependent or independent of subtype. We have generated mRNA, miRNA, and DNA copy-number profiles from a total of 59 in situ lesions and 85 invasive tumors in order to comprehensively identify those genes, signaling pathways, processes, and cell types that are involved in breast cancer progression. Our work provides evidence that there are molecular features associated with disease progression that are unique to the intrinsic subtypes. We additionally establish subtype-specific signatures that are able to identify a small proportion of pre-invasive tumors with expression profiles that resemble invasive carcinoma, indicating a higher likelihood of future disease progression.

Place, publisher, year, edition, pages
2016. Vol. 16, no 4, 1166-1179 p.
National Category
Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:uu:diva-303121DOI: 10.1016/j.celrep.2016.06.051ISI: 000380265500023PubMedID: 27396337OAI: oai:DiVA.org:uu-303121DiVA: diva2:971239
Available from: 2016-09-15 Created: 2016-09-15 Last updated: 2016-09-15Bibliographically approved

Open Access in DiVA

fulltext(6692 kB)14 downloads
File information
File name FULLTEXT01.pdfFile size 6692 kBChecksum SHA-512
f7e0c426240d1f8d0d21c7aba215136ade187d7e38d5d81e8a709528bf7098d7539959dd9ccca87bd7207d102ccd0a18c3198bf294bb836f6c2941e69566a07e
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Wämberg, Fredrik
By organisation
Endocrine Surgery
In the same journal
Cell reports
Cell and Molecular Biology

Search outside of DiVA

GoogleGoogle Scholar
Total: 14 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 9 hits
ReferencesLink to record
Permanent link

Direct link