Change search
ReferencesLink to record
Permanent link

Direct link
Small Mouse Islets Are Deficient in Glucagon-Producing Alpha Cells but Rich in Somatostatin-Secreting Delta Cells
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
2016 (English)In: Journal of Diabetes Research, ISSN 2314-6745, E-ISSN 2314-6753, 4930741Article in journal (Refereed) Published
Abstract [en]

Small and big mouse islets were compared with special reference to their content of glucagon-producing alpha-cells and somatostatin-producing delta-cells. Areas stained for glucagon and somatostatin were measured in the largest cross section of small (diameter < 60 mu m) and big (diameter > 100 mu m) islets. Comparison of the areas indicated proportionally more delta- than alpha-cells in the small islets. After isolation with collagenase these islets were practically devoid of alpha-cells. We evaluated the functional importance of the islet size by measuring the Ca2+ signal for insulin release. A majority of the small islets responded to the hyperpolarization action of somatostatin with periodic decrease of cytoplasmic Ca2+ when glucose was elevated after tolbutamide blockade of the K-ATP channels.

Place, publisher, year, edition, pages
2016. 4930741
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:uu:diva-303157DOI: 10.1155/2016/4930741ISI: 000381148200001OAI: oai:DiVA.org:uu-303157DiVA: diva2:970991
Funder
Swedish Research CouncilSwedish Diabetes Association
Available from: 2016-09-15 Created: 2016-09-15 Last updated: 2016-09-15Bibliographically approved

Open Access in DiVA

fulltext(3437 kB)10 downloads
File information
File name FULLTEXT01.pdfFile size 3437 kBChecksum SHA-512
c6e328b7e1f960bdbadf4ad48ed15183dfaa6a68f3c5fa4ecd7b197dbf7fa99c22a6965e66443d718911c278e0d01870657a2237cf09b68831e093255a46467a
Type fulltextMimetype application/pdf

Other links

Publisher's full text

Search in DiVA

By author/editor
Lau, JoeyGrapengiesser, EvaHellman, Bo
By organisation
Department of Medical Cell Biology
In the same journal
Journal of Diabetes Research
Endocrinology and Diabetes

Search outside of DiVA

GoogleGoogle Scholar
Total: 10 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 10 hits
ReferencesLink to record
Permanent link

Direct link