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Persisters - as elusive as ever
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS). University of Tartu, Institute of Technology, Nooruse 1, 50411 Tartu, Estonia.
2016 (English)In: Applied Microbiology and Biotechnology, ISSN 0175-7598, E-ISSN 1432-0614, Vol. 100, no 15, 6545-6553 p.Article, review/survey (Refereed) PublishedText
Abstract [en]

Persisters-a drug-tolerant sub-population in an isogenic bacterial culture-have been featured throughout the last decade due to their important role in recurrent bacterial infections. Numerous investigations detail the mechanisms responsible for the formation of persisters and suggest exciting strategies for their eradication. In this review, we argue that the very term "persistence" is currently used to describe a large and heterogeneous set of physiological phenomena that are functions of bacterial species, strains, growth conditions, and antibiotics used in the experiments. We caution against the oversimplification of the mechanisms of persistence and urge for a more rigorous validation of the applicability of these mechanisms in each case.

Place, publisher, year, edition, pages
2016. Vol. 100, no 15, 6545-6553 p.
Keyword [en]
Antibiotic tolerance, Antibiotic resistance, Persisters, Bet hedging, Antibiotic development, Bacterial infections
National Category
Microbiology in the medical area
Identifiers
URN: urn:nbn:se:umu:diva-124313DOI: 10.1007/s00253-016-7648-8ISI: 000379317300003PubMedID: 27262568OAI: oai:DiVA.org:umu-124313DiVA: diva2:958157
Available from: 2016-09-06 Created: 2016-08-04 Last updated: 2016-09-06Bibliographically approved

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Hauryliuk, Vasili
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Department of Molecular Biology (Faculty of Medicine)Molecular Infection Medicine Sweden (MIMS)
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