Change search
ReferencesLink to record
Permanent link

Direct link
Maternal Micronutrient Supplementation and Long Term Health Impact in Children in Rural Bangladesh
Immunobiology, Nutrition and Toxicology Laboratory, Infectious Diseases Division, icddr,b, Dhaka, Bangladesh.; Bangladesh Univ Hlth Sci, Dept Immunol, Dhaka, Bangladesh.
Immunobiology, Nutrition and Toxicology Laboratory, Infectious Diseases Division, icddr,b, Dhaka, Bangladesh.
Immunobiology, Nutrition and Toxicology Laboratory, Infectious Diseases Division, icddr,b, Dhaka, Bangladesh.
Immunobiology, Nutrition and Toxicology Laboratory, Infectious Diseases Division, icddr,b, Dhaka, Bangladesh.
Show others and affiliations
2016 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 11, no 8, e0161294Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Limited data is available on the role of prenatal nutritional status on the health of school-age children. We aimed to determine the impact of maternal micronutrient supplementation on the health status of Bangladeshi children.

METHODS: Children (8.6-9.6 years; n = 540) were enrolled from a longitudinal mother-child cohort, where mothers were supplemented daily with either 30mg iron and 400μg folic acid (Fe30F), or 60mg iron and 400μg folic acid (Fe60F), or Fe30F including 15 micronutrients (MM), in rural Matlab. Blood was collected from children to determine the concentration of hemoglobin (Hb) and several micronutrients. Anthropometric and Hb data from these children were also available at 4.5 years of age and mothers at gestational week (GW) 14 and 30.

RESULTS: MM supplementation significantly improved (p≤0.05) body mass index-for-age z-score (BAZ), but not Hb levels, in 9 years old children compared to the Fe30F group. MM supplementation also reduced markers of inflammation (p≤0.05). About 28%, 35% and 23% of the women were found to be anemic at GW14, GW30 and both time points, respectively. The prevalence of anemia was 5% and 15% in 4.5 and 9 years old children, respectively. The adjusted odds of having anemia in 9 year old children was 3-fold higher if their mothers were anemic at both GW14 and GW30 [Odds Ratio (OR) = 3.05; 95% Confidence Interval (CI) 1.42, 6.14, P = 0.002] or even higher if they were also anemic at 4.5 years of age [OR = 5.92; 95% CI 2.64, 13.25; P<0.001].

CONCLUSION: Maternal micronutrient supplementation imparted beneficial effects on child health. Anemia during pregnancy and early childhood are important risk factors for the occurrence of anemia in school-age children.

Place, publisher, year, edition, pages
2016. Vol. 11, no 8, e0161294
National Category
Nutrition and Dietetics
Identifiers
URN: urn:nbn:se:uu:diva-302500DOI: 10.1371/journal.pone.0161294ISI: 000381577000083PubMedID: 27537051OAI: oai:DiVA.org:uu-302500DiVA: diva2:957871
Funder
Sida - Swedish International Development Cooperation Agency
Available from: 2016-09-05 Created: 2016-09-05 Last updated: 2016-10-26Bibliographically approved

Open Access in DiVA

fulltext(549 kB)5 downloads
File information
File name FULLTEXT01.pdfFile size 549 kBChecksum SHA-512
59ed2f384bb7e956042c03a2bd3d15d70fd9abd38d7d9a1083e5f69f2ada40b910076c961cca2ea9d1bcf1d5a6e843baf5c99e0c4905f24c0e689c46e6975a35
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Ekström, Eva-Charlotte
By organisation
Department of Women's and Children's Health
In the same journal
PLoS ONE
Nutrition and Dietetics

Search outside of DiVA

GoogleGoogle Scholar
Total: 5 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 15 hits
ReferencesLink to record
Permanent link

Direct link