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Data on the expression of cellular lncRNAs in human adenovirus infected cells
LaTrobeUniversity.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medicinsk genetik och genomik. (Pettersson)
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC, Analytical Chemistry. (Lind)ORCID iD: 0000-0002-9510-3816
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medicinsk genetik och genomik. (Pettersson)
2016 (English)In: Data in Brief, ISSN 1529-4188, E-ISSN 1683-1470, Vol. 8, 1263-1279 p.Article in journal (Refereed) Published
Abstract [en]

Expression of cellular long non-coding RNAs (lncRNAs) in human primary lung fibroblasts (IMR-90) during the course of adenovirus type 2 (Ad2) infection was studied by strand-specific whole transcriptome sequencing. In total, 645 cellular lncRNAs were expressed at a significant level and 398 of them were changed more than 2-fold. The changes in expression followed a distinct temporal pattern. Significantly, 80% of the changes occurred at the late phase and 80% of the de-regulated lncRNAs were up-regulated. The three largest groups of deregulated lncRNAs were 125 antisense RNAs, 111 pseudogenes and 85 long intergenic non-coding RNAs (lincRNAs). Lastly, more than 36% of lncRNAs have been shown to interact with RNA binding proteins.

Place, publisher, year, edition, pages
Elsevier, 2016. Vol. 8, 1263-1279 p.
Keyword [en]
Adenovirus;Long noncodingRNA;IncRNA; IMR90
National Category
Medical Genetics
Research subject
Medical Genetics
Identifiers
URN: urn:nbn:se:uu:diva-301964DOI: 10.1016/j.dib.2016.06.053PubMedID: 27547808OAI: oai:DiVA.org:uu-301964DiVA: diva2:955780
Funder
Magnus Bergvall Foundation, 2015-01200Åke Wiberg Foundation
Available from: 2016-08-26 Created: 2016-08-26 Last updated: 2016-08-26Bibliographically approved

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