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Glass Ionomer Cements with Improved Bioactive and Antibacterial Properties
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences. (materials in medicine)
2016 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Dental restorative cements are placed in a harsh oral environment where they are subjected to thermal shock, chemical degradation, and repeating masticatory force. The ideal restorative dental cements should have superior mechanical properties, chemical stability, aesthetic, good handling properties, biocompatibility, antibacterial properties, and preferably bioactivity. This thesis presents research on dental restorative cements with enhanced properties. The overall aim was to increase the bioactivity and antibacterial properties of dental restorative cements without affecting their other properties.

The effect from adding calcium silicate to glass ionomer cement (GIC) was investigated. The results showed that calcium silicate could increase the bioactivity and reduce the cytotoxicity of conventional glass ionomer cement without compromising its setting and mechanical properties.

Hydroxyapatite (HA) with a high aspect ratio and thin nacreous-layered monetite sheets were also synthesized. Nano HA particles with an aspect ratio of 50 can be synthesized by both precipitation and hydrothermal methods. The aspect ratio was controlled via the pH of reaction medium. Thin nacreous-layered monetite sheets were synthesized through a self-assembly process in the presence of an amine based cationic quaternary surfactant. Temperature, pH, and presence of surfactant played essential roles in forming the nacreous-layered monetite sheets. Then the effect from adding silver doped HA and monetite particles was investigated. The results showed that the antibacterial properties of GIC could be increased by incorporating silver doped HA and monetite particles. Further examination showed that the pH change, F- ion release, and concentration of released Ag+ ions were not responsible for the improved antibacterial properties.

The quasi-static strengths and compressive fatigue limits of four types of the most commonly used dental restorations were evaluated. In our study, resin modified GIC and resin-based composite showed superior static compressive strength and fatigue limits compared to conventional GIC. The static compressive strength of dental cements increased with the aging time. However, aging had no effect on the compressive fatigue limit of resin modified GIC and resin-based composite. The compressive fatigue limit of conventional GIC even showed a drastic decrease after aging.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2016. , 62 p.
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology, ISSN 1651-6214 ; 1413
Keyword [en]
biomaterial, glass ionomer cement, bioactivity, hydroxyapatite, monetite, calcium silicate
National Category
Biomaterials Science
Identifiers
URN: urn:nbn:se:uu:diva-301924ISBN: 978-91-554-9670-8OAI: oai:DiVA.org:uu-301924DiVA: diva2:955683
Public defence
2016-10-14, Å2005, Ångströmlaboratoriet, Lägerhyddsvägen 1, Uppsala, 09:15 (English)
Opponent
Supervisors
Available from: 2016-09-21 Created: 2016-08-25 Last updated: 2016-09-22
List of papers
1. Enhanced bioactivity of glass ionomer cement by incorporating calcium silicates
Open this publication in new window or tab >>Enhanced bioactivity of glass ionomer cement by incorporating calcium silicates
2016 (English)In: Biomatter, ISSN 2159-2527, E-ISSN 2159-2535, Vol. 6, no 1, e1123842-1-e1123842-13 p.Article in journal (Refereed) Published
National Category
Materials Engineering
Identifiers
urn:nbn:se:uu:diva-281936 (URN)
External cooperation:
Available from: 2016-03-31 Created: 2016-03-31 Last updated: 2016-09-02
2. Cytotoxicity of modified glass ionomer cement on odontoblast cells
Open this publication in new window or tab >>Cytotoxicity of modified glass ionomer cement on odontoblast cells
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2016 (English)In: Journal of materials science. Materials in medicine, ISSN 0957-4530, E-ISSN 1573-4838, Vol. 27, no 7, 116Article in journal (Refereed) Published
Abstract [en]

Recently a modified glass ionomer cement (GIC) with enhanced bioactivity due to the incorporation of wollastonite or mineral trioxide aggregate (MTA) has been reported. The aim of this study was to evaluate the cytotoxic effect of the modified GIC on odontoblast-like cells. The cytotoxicity of a conventional GIC, wollastonite modified GIC (W-mGIC), MTA modified GIC (M-mGIC) and MTA cement has been evaluated using cement extracts, a culture media modified by the cement. Ion concentration and pH of each material in the culture media were measured and correlated to the results of the cytotoxicity study. Among the four groups, conventional GIC showed the most cytotoxicity effect, followed by W-mGIC and M-mGIC. MTA showed the least toxic effect. GIC showed the lowest pH (6.36) while MTA showed the highest (8.62). In terms of ion concentration, MTA showed the largest Ca2+ concentration (467.3 mg/L) while GIC showed the highest concentration of Si4+ (19.9 mg/L), Al3+ (7.2 mg/L) and Sr2+ (100.3 mg/L). Concentration of F- was under the detection limit (0.02 mg/L) for all samples. However the concentrations of these ions are considered too low to be toxic. Our study showed that the cytotoxicity of conventional GIC can be moderated by incorporating calcium silicate based ceramics. The modified GIC might be promising as novel dental restorative cements.

National Category
Cell Biology Materials Chemistry Engineering and Technology
Identifiers
urn:nbn:se:uu:diva-297514 (URN)10.1007/s10856-016-5729-y (DOI)000379031200002 ()27221819 (PubMedID)
Funder
Swedish Research Council, 2013-5419 2011-3399EU, FP7, Seventh Framework ProgrammeVINNOVALars Hierta Memorial Foundation, FO2014-0334
Available from: 2016-06-23 Created: 2016-06-23 Last updated: 2016-08-26Bibliographically approved
3. Compressive fatigue limit of four types of dental restorative materials
Open this publication in new window or tab >>Compressive fatigue limit of four types of dental restorative materials
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2016 (English)In: Journal of The Mechanical Behavior of Biomedical Materials, ISSN 1751-6161, E-ISSN 1878-0180, Vol. 61, 283-289 p.Article in journal (Refereed) Published
Abstract [en]

The purpose of this study was to evaluate the quasi-static compressive strength and the compressive fatigue limit of four different dental restorative materials, before and after aging in distilled water for 30 days. A conventional glass ionomer cement (Fuji IX GP; IG), a zinc-reinforced glass ionomer cement (Chemfil rock; CF), a light curable resin-reinforced glass ionomer cement (Fuji II LC; LC) and a resin-based composite (Quixfil; QF) were investigated. Cylindrical specimens (4 mm in diameter and 6 mm in height) were prepared according to the manufacturer's instructions. The compressive fatigue limit was obtained using the staircase method. Samples were tested in distilled water at 37 degrees C, at a frequency of 10 Hz with 10(5) cycles set as run-out. 17 fatigue samples were tested for each group. Two-way ANOVA and one-way ANOVA followed by Tukey's post-hoc test were used to analyze the results. Among the four types of materials, the resin-based composite exhibited the highest compressive strength (244 +/- 13.0 MPa) and compressive fatigue limit (134 +/- 7.8 MPa), followed by the light-cured resin reinforced glass ionomer cement (168 +/- 8.5 MPa and 92 +/- 6.6 MPa, respectively) after one day of storage in distilled water. After being stored for 30 days, all specimens showed an increase in compressive strength. Aging showed no effect on the compressive fatigue limit of the resin-based composite and the light-cured resin reinforced glass ionomer cement, however, the conventional glass ionomer cements showed a drastic decrease (37% for IG, 31% for CF) in compressive fatigue limit. In conclusion, in the present study, resin modified GIC and resin-based composite were found to have superior mechanical properties to conventional GIC.

Keyword
Dental restorative materials; Fatigue; Aging; Compressive
National Category
Materials Engineering
Identifiers
urn:nbn:se:uu:diva-281942 (URN)10.1016/j.jmbbm.2016.03.031 (DOI)
Available from: 2016-03-31 Created: 2016-03-31 Last updated: 2016-09-19Bibliographically approved
4. Highly repeatable synthesis of nHA with high aspect ratio
Open this publication in new window or tab >>Highly repeatable synthesis of nHA with high aspect ratio
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2015 (English)In: Materials letters (General ed.), ISSN 0167-577X, E-ISSN 1873-4979, Vol. 159, 163-167 p.Article in journal (Refereed) Published
National Category
Biomaterials Science Engineering and Technology
Identifiers
urn:nbn:se:uu:diva-265712 (URN)10.1016/j.matlet.2015.06.086 (DOI)000362603000043 ()
Funder
Swedish Research Council, 2013-5419VINNOVA, 2010-01907EU, FP7, Seventh Framework Programme, INFRA-2010-262163
Available from: 2015-11-02 Created: 2015-11-02 Last updated: 2016-08-26
5. Synthesis of calcium phosphate crystals with thin nacreous structure
Open this publication in new window or tab >>Synthesis of calcium phosphate crystals with thin nacreous structure
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2016 (English)In: CrystEngComm, ISSN 1466-8033, E-ISSN 1466-8033, Vol. 18, no 6, 1064-1069 p.Article in journal (Refereed) Published
Abstract [en]

Nacre-like structures have attracted great interest in recent years due to their outstanding toughness, stiffness and impact resistance. However, there is a challenge associated with engineering nacre-like calcium phosphate crystals. In this study, thin nacreous-like monetite sheets were synthesized in solutions guided by a surfactant. The influence of temperature, initial pH, Ca/P ratio, stirring time and the concentration of cetyltrimethylammonium bromide (CTAB) on the nacre-like structure has been studied. Findings showed that a nacre-like structure could only be formed at a high temperature (90 degrees C), high initial pH (11), sufficient stirring time (3 h), and under the presence of CTAB. A small-angle X-ray scattering experiment carried out at a synchrotron radiation facility showed that the distance between nanolayers was around 2.6 nm and TEM confirmed the fine sheet-like structure. The mechanism of the formation the nacre-like structure and its characterization were discussed.

National Category
Bio Materials
Identifiers
urn:nbn:se:uu:diva-274987 (URN)10.1039/c5ce02078f (DOI)000369609800025 ()
Funder
Swedish Research Council, 2013-5419Knut and Alice Wallenberg Foundation
Available from: 2016-01-27 Created: 2016-01-27 Last updated: 2016-08-26Bibliographically approved
6. Synthesis of Ag doped calcium phosphate particles and their antibacterial effect as additives in dental glass ionomer cements
Open this publication in new window or tab >>Synthesis of Ag doped calcium phosphate particles and their antibacterial effect as additives in dental glass ionomer cements
(English)Article in journal (Refereed) Accepted
National Category
Ceramics
Identifiers
urn:nbn:se:uu:diva-301918 (URN)
External cooperation:
Available from: 2016-08-25 Created: 2016-08-25 Last updated: 2016-08-26

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