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Sub-Optimal Treatment of Bacterial Biofilms
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS). Umeå University, Faculty of Medicine, Department of Clinical Microbiology.
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS).
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).
2016 (English)In: Antibiotics, ISSN 0066-4774, E-ISSN 2079-6382, Vol. 5, no 2, 23Article, review/survey (Refereed) PublishedText
Abstract [en]

Bacterial biofilm is an emerging clinical problem recognized in the treatment of infectious diseases within the last two decades. The appearance of microbial biofilm in clinical settings is steadily increasing due to several reasons including the increased use of quality of life-improving artificial devices. In contrast to infections caused by planktonic bacteria that respond relatively well to standard antibiotic therapy, biofilm-forming bacteria tend to cause chronic infections whereby infections persist despite seemingly adequate antibiotic therapy. This review briefly describes the responses of biofilm matrix components and biofilm-associated bacteria towards sub-lethal concentrations of antimicrobial agents, which may include the generation of genetic and phenotypic variabilities. Clinical implications of bacterial biofilms in relation to antibiotic treatments are also discussed.

Place, publisher, year, edition, pages
2016. Vol. 5, no 2, 23
Keyword [en]
biofilm development, sub-optimal treatment, antibiotic tolerance, anti-biofilm agents
National Category
Infectious Medicine Microbiology in the medical area
Identifiers
URN: urn:nbn:se:umu:diva-124514DOI: 10.3390/antibiotics5020023ISI: 000379982400009OAI: oai:DiVA.org:umu-124514DiVA: diva2:955485
Available from: 2016-08-25 Created: 2016-08-15 Last updated: 2016-08-25Bibliographically approved

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Song, TianyanDuperthuy, MaryliseWai, Sun Nyunt
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